RARG

Summary

Gene Symbol: RARG
Description: retinoic acid receptor gamma
Alias: NR1B3, RARC, retinoic acid receptor gamma, RAR-gamma, nuclear receptor subfamily 1 group B member 3, retinoic acid nuclear receptor gamma variant 1, retinoic acid nuclear receptor gamma variant 2
Species: human

Top Publications

  1. pmc Impact of previous abdominal surgery on robot-assisted radical cystectomy
    Bertram E Yuh
    Department of Urology, State University of New York at Buffalo, USA
    JSLS 13:398-405. 2009
  2. doi Robot-assisted radical cystectomy: intermediate survival results at a mean follow-up of 25 months
    Aaron D Martin
    Department of Urology, Mayo Clinic, Phoenix, AZ, USA
    BJU Int 105:1706-9. 2010
  3. doi Robot-assisted radical cystectomy: recent advances and review of the literature
    Michael E Woods
    Department of Urology, Loyola University Medical Center, Maywood, Illinois, USA
    Curr Opin Urol 20:125-9. 2010
  4. pmc LIM kinase 1 - dependent cofilin 1 pathway and actin dynamics mediate nuclear retinoid receptor function in T lymphocytes
    Mohammad Ishaq
    Laboratory of Molecular Cell Biology, SAIC Frederick, National Cancer Institute, Frederick, MD 21702, USA
    BMC Mol Biol 12:41. 2011
  5. ncbi Modulation of aromatase expression in the breast tissue by ERR alpha-1 orphan receptor
    C Yang
    Division of Immunology, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA
    Cancer Res 58:5695-700. 1998
  6. ncbi Vinexin beta interacts with the non-phosphorylated AF-1 domain of retinoid receptor gamma (RARgamma) and represses RARgamma-mediated transcription
    Gaétan Bour
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, Unite Mixte de Recherche 7104, 67404 Illkirch Cedex, France
    J Biol Chem 280:17027-37. 2005
  7. pmc Genomic antagonism between retinoic acid and estrogen signaling in breast cancer
    Sujun Hua
    Institute for Genomics and Systems Biology and Department of Human Genetics, The University of Chicago, 920 East 58th Street, Chicago, IL 60637, USA
    Cell 137:1259-71. 2009
  8. ncbi Hoxd4 and Rarg interact synergistically in the specification of the cervical vertebrae
    A Folberg
    McGill Cancer Centre, McGill University, Montreal, Quebec, Canada
    Mech Dev 89:65-74. 1999
  9. doi Gene and microRNA expression in p53-deficient day 8.5 mouse embryos
    Hiromi Hosako
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, 434 VMR Building, College Station, TX 77843, USA
    Birth Defects Res A Clin Mol Teratol 85:546-55. 2009
  10. ncbi Male-to-male transmission in Laurin-Sandrow syndrome and exclusion of RARB and RARG
    Klaus W Kjaer
    Department of Medical Biochemistry and Genetics, Wilhelm Johannsen Center for Functional Genome Research, University of Copenhagen, Panum Institute 24 4, Blegdamsvej 3, 2200 Copenhagen N, Denmark
    Am J Med Genet A 137:148-52. 2005

Research Grants

  1. RETINOIC ACID RECEPTOR GAMMA SPECIFIC SIGNALING IN MELAN
    REMCO SPANJAARD; Fiscal Year: 2004
  2. Dipen Parekh; Fiscal Year: 2015
  3. RETINOIC ACID--ROLE IN DIFFERENTIATION
    Lorraine Gudas; Fiscal Year: 2002
  4. RETINOIC ACID SIGNALING IN EARLY LUNG MORPHOGENESIS
    Margaret Rush; Fiscal Year: 2001
  5. Retinoid Signaling in Neural Patterning in Zebrafish
    Thomas Schilling; Fiscal Year: 2009
  6. NEGATIVE REGULATION OF GENE EXPRESSION BY VITAMIN D
    NICHOLAS KOSZEWSKI; Fiscal Year: 2002
  7. TOPOISOMERASES IN RETINOID INDUCED DIFFERENTIATION
    Andrew Yen; Fiscal Year: 2003
  8. FLUORESCENCE ACTIVATED CELL SORTER
    Andrew Yen; Fiscal Year: 2004
  9. Retinoic Acid Regulated Cell Differentiation: BLR1 Rcptr
    Andrew Yen; Fiscal Year: 2005

Scientific Experts

Detail Information

Publications162 found, 100 shown here

  1. pmc Impact of previous abdominal surgery on robot-assisted radical cystectomy
    Bertram E Yuh
    Department of Urology, State University of New York at Buffalo, USA
    JSLS 13:398-405. 2009
    We analyzed the effect of previous abdominal surgery (PAS) on consecutive patients who underwent robot-assisted radical cystectomy (RARC).
  2. doi Robot-assisted radical cystectomy: intermediate survival results at a mean follow-up of 25 months
    Aaron D Martin
    Department of Urology, Mayo Clinic, Phoenix, AZ, USA
    BJU Int 105:1706-9. 2010
    To assess the overall and disease-specific survival rates of patients undergoing robot-assisted radical cystectomy (RARC) compared with historical open cystectomy.
  3. doi Robot-assisted radical cystectomy: recent advances and review of the literature
    Michael E Woods
    Department of Urology, Loyola University Medical Center, Maywood, Illinois, USA
    Curr Opin Urol 20:125-9. 2010
    Robot-assisted radical cystectomy (RARC) continues to provide a minimally invasive option to the management of bladder cancer. Its utilization appears to be steadily increasing...
  4. pmc LIM kinase 1 - dependent cofilin 1 pathway and actin dynamics mediate nuclear retinoid receptor function in T lymphocytes
    Mohammad Ishaq
    Laboratory of Molecular Cell Biology, SAIC Frederick, National Cancer Institute, Frederick, MD 21702, USA
    BMC Mol Biol 12:41. 2011
    ..Here we have investigated the role of actin dynamics and the effect of actin cytoskeleton modifying agents on retinoid receptor-mediated transactivation...
  5. ncbi Modulation of aromatase expression in the breast tissue by ERR alpha-1 orphan receptor
    C Yang
    Division of Immunology, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA
    Cancer Res 58:5695-700. 1998
    ..of the positive clones encode for ERR alpha-1, and other positive clones include EAR-2, EAR-3 (COUP-TF1), RAR gamma, and p120E4F...
  6. ncbi Vinexin beta interacts with the non-phosphorylated AF-1 domain of retinoid receptor gamma (RARgamma) and represses RARgamma-mediated transcription
    Gaétan Bour
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, Unite Mixte de Recherche 7104, 67404 Illkirch Cedex, France
    J Biol Chem 280:17027-37. 2005
    ..We propose a model in which phosphorylation of the AF-1 domain controls RARgamma-mediated transcription through triggering the dissociation of vinexin beta...
  7. pmc Genomic antagonism between retinoic acid and estrogen signaling in breast cancer
    Sujun Hua
    Institute for Genomics and Systems Biology and Department of Human Genetics, The University of Chicago, 920 East 58th Street, Chicago, IL 60637, USA
    Cell 137:1259-71. 2009
    ....
  8. ncbi Hoxd4 and Rarg interact synergistically in the specification of the cervical vertebrae
    A Folberg
    McGill Cancer Centre, McGill University, Montreal, Quebec, Canada
    Mech Dev 89:65-74. 1999
    We show that, relative to single null mutants, mice bearing mutations in both Hoxd4 and Rarg display malformations of the basioccipital bone, and first (C1) and second cervical vertebrae (C2) at increased penetrance and expressivity, ..
  9. doi Gene and microRNA expression in p53-deficient day 8.5 mouse embryos
    Hiromi Hosako
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, 434 VMR Building, College Station, TX 77843, USA
    Birth Defects Res A Clin Mol Teratol 85:546-55. 2009
    ..Here we attempt to identify genes and microRNAs (miRNAs) modified by deletion of p53 in day 8.5 mouse embryos...
  10. ncbi Male-to-male transmission in Laurin-Sandrow syndrome and exclusion of RARB and RARG
    Klaus W Kjaer
    Department of Medical Biochemistry and Genetics, Wilhelm Johannsen Center for Functional Genome Research, University of Copenhagen, Panum Institute 24 4, Blegdamsvej 3, 2200 Copenhagen N, Denmark
    Am J Med Genet A 137:148-52. 2005
    ..formation and early in limb formation we identified retinoic acid receptor B (RARB) and retinoic acid receptor G (RARG) as possible candidate genes and sequenced bidirectionally including all exons and intron-exon bounders...
  11. doi Robot-assisted extended pelvic lymphadenectomy
    Michael Woods
    Department of Urology, Tulane University Medical Center, New Orleans, Louisiana, USA
    J Endourol 22:1297-302. 2008
    ..To evaluate perioperative and pathologic outcomes of patients undergoing robot-assisted extended pelvic lymphadenectomy for bladder cancer...
  12. ncbi Linkage mapping of the retinoic acid receptor-gamma gene to porcine chromosome 5
    L Messer
    Department of Animal Science, Iowa State University, Ames 50011 3150, USA
    Anim Genet 27:175-7. 1996
    The porcine retinoic acid receptor-gamma gene (RARG) has been mapped by restriction fragment length polymorphism analysis to porcine chromosome 5...
  13. pmc Highly twisted adamantyl arotinoids: synthesis, antiproliferative effects and RXR transactivation profiles
    Santiago Pérez-Rodríguez
    Departamento de Quimica Organica, Universidade de Vigo, Lagoas Marcosende, 36310 Vigo, Spain
    Eur J Med Chem 44:2434-46. 2009
    ..arotinoids) have been described with selective activities towards the retinoid receptors as agonists for NR1B2 and NR1B3 (RARbeta,gamma) (CD437, MX3350-1) or RAR antagonists (MX781) that induce growth arrest and apoptosis in cancer ..
  14. doi Retinoic acid receptors exhibit cell-autonomous functions in cranial neural crest cells
    Valérie Dupé
    Faculte de Medecine, Institut de Génétique et Développement, Universite de Rennes 1, Rennes Cedex, France
    Dev Dyn 238:2701-11. 2009
    ..However, ablation of Rara and Rarg genes in NCC yields an agenesis of the median portion of the face, demonstrating that RARalpha and RARgamma act ..
  15. ncbi Mapping of the mouse Rar loci encoding retinoic acid receptors RAR alpha, RAR beta and RAR gamma
    M Taketo
    Department of Microbiology and Immunology, Duke University Medical Center, Durham, NC 27710
    Jpn J Genet 68:175-84. 1993
    Nuclear retinoic acid receptors RAR alpha, RAR beta and RAR gamma are transcription factors that bind all-trans retinoic acid as their ligand and mediate its action by activating particular set of genes that contain retinoic acid ..
  16. doi Does the presence of significant risk factors affect perioperative outcomes after robot-assisted radical cystectomy?
    Zubair M Butt
    Urologic Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    BJU Int 104:986-90. 2009
    To evaluate the effect of preoperative risk factors on perioperative outcomes up to 3 months after robot-assisted radical cystectomy (RARC), as RC continues to be associated with a high rate of morbidity and mortality.
  17. ncbi Retinoic acid inhibition of IL-1-induced IL-6 production by human lung fibroblasts
    R J Zitnik
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510 8040
    J Immunol 152:1419-27. 1994
    ..These studies demonstrate that RA and other retinoid analogs inhibit IL-1-induced IL-6 production and that this effect is analog-specific and, at least partially, transcriptionally mediated...
  18. doi Robot-assisted radical cystectomy in women: technique and initial experience
    Benjamin H Lowentritt
    Department of Urology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Endourol 22:709-12. 2008
    Robot-assisted radical cystectomy (RARC) is a new management option for the treatment of bladder cancer. This study evaluates an initial experience with RARC with ileal conduit diversion in women.
  19. doi Impact of tumour volume on surgical and pathological outcomes after robot-assisted radical cystectomy
    Bertram Yuh
    Department of Urology, State University of New York at Buffalo, Buffalo, New York, NY, USA
    BJU Int 102:840-3. 2008
    ..that bladder tumour volume has on operative and pathological outcomes after robotic-assisted radical cystectomy (RARC, a minimally invasive alternative to open cystectomy for treating bladder cancer), as with the lack of tactile ..
  20. doi Short-term quality-of-life assessed after robot-assisted radical cystectomy: a prospective analysis
    Bertram Yuh
    Urology, State University of New York at Buffalo, Buffalo, New York, NY, USA
    BJU Int 103:800-4. 2009
    To prospectively determine the effect of robot-assisted radical cystectomy (RARC) on quality of life (QoL) after surgery.
  21. pmc Human ADA3 regulates RARalpha transcriptional activity through direct contact between LxxLL motifs and the receptor coactivator pocket
    Chia Wei Li
    Department of Pharmacology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854, New Jersey, USA
    Nucleic Acids Res 38:5291-303. 2010
    ..These results suggest that hADA3 is a bona fide transcriptional coactivator for RARα, acting through a conserved mechanism involving direct contacts between NR boxes and the receptor's co-activator pocket...
  22. doi Restricted microbiota and absence of cognate TCR antigen leads to an unbalanced generation of Th17 cells
    Matthias Lochner
    Lymphoid Tissue Development Unit, Department of Immunology, Institut Pasteur, 75724 Paris, France
    J Immunol 186:1531-7. 2011
    ..These results demonstrate that a complex microbiota and cognate Ag are required to generate a properly regulated set of RORγt(+) T cells and Th17 cells...
  23. pmc Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor gamma and liver receptor homolog 1
    Wei Wang
    Wellcome Trust Sanger Institute, Hinxton CB10 1HH, United Kingdom
    Proc Natl Acad Sci U S A 108:18283-8. 2011
    ..Coexpressing Rarg (RAR-γ) and Lrh-1 (liver receptor homologue 1; Nr5a2) with the four factors greatly accelerated reprogramming so ..
  24. doi Development and validation of the attention questionnaire of rehabilitated athletes returning to competition
    Anna Christakou
    Department of Physical Education and Sports Sciences, University of Athens, Dafne, Greece
    Psychol Health Med 17:499-510. 2012
    ..a musculoskeletal injury--the attention questionnaire of rehabilitated athletes returning to competition (AQ-RARC)...
  25. doi Robotic versus open radical cystectomy: identification of patients who benefit from the robotic approach
    Michael L Knox
    Division of Urology, Department of Surgery, University of Alabama Birmingham, Birmingham, Alabama 35294, USA
    J Endourol 27:40-4. 2013
    To identify patients who would benefit from robot-assisted radical cystectomy (RARC), we report perioperative outcomes and complications.
  26. pmc Retinoic acid induces Sertoli cell paracrine signals for spermatogonia differentiation but cell autonomously drives spermatocyte meiosis
    Mathilde Raverdeau
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Unité Mixte de Recherche 7104, Institut National de la Santé et de la Recherche Médicale Unité 964, Universite de Strasbourg, Illkirch, France
    Proc Natl Acad Sci U S A 109:16582-7. 2012
    ..enzymes, the retinaldehyde dehydrogenases (RALDH), and binds to and activates nuclear RA receptors (RARA, RARB, and RARG) either within the RA-synthesizing cells or in the neighboring cells...
  27. doi Long-term outcomes of robot-assisted radical cystectomy for bladder cancer
    Muhammad Shamim Khan
    Urology Centre, Guy s and St Thomas NHS Foundation Trust, Great Maze Pond, London SE1 9RT, United Kingdom
    Eur Urol 64:219-24. 2013
    Long-term oncologic and functional outcomes after robot-assisted radical cystectomy (RARC) for bladder cancer (BCa) are lacking.
  28. pmc CDK1 interacts with RARγ and plays an important role in treatment response of acute myeloid leukemia
    Andreas Hedblom
    Department of Laboratory Medicine, Division of Experimental Cancer Research, Clinical Research Center, Lund University, Malmo, Sweden
    Cell Cycle 12:1251-66. 2013
    ..Our study reveals a novel mechanism by which CDK1 and RARγ coordinate with ATRA to influence cell cycle progression and cellular differentiation...
  29. doi Short-term patient reported health-related quality of life (HRQL) outcomes after robot-assisted radical cystectomy (RARC)
    Michael A Poch
    Department of Urology, Roswell Park Cancer Institute, Buffalo, NY, USA
    BJU Int 113:260-5. 2014
    To determine short-term health-related quality of life (HRQL) outcomes after robot-assisted radical cystectomy (RARC) using the Bladder Cancer Index (BCI) and European Organisation for Research and Treatment of Cancer (EORTC) Body Image ..
  30. doi Robot-assisted radical cystectomy (RARC) with intracorporeal neobladder - what is the effect of the learning curve on outcomes?
    Justin W Collins
    Department of Molecular Medicine and Surgery, Section of Urology, Karolinska Institutet, Stockholm, Sweden
    BJU Int 113:100-7. 2014
    ....
  31. doi Robotic-assisted radical cystectomy with extracorporeal urinary diversion for urothelial carcinoma of the bladder: analysis of complications and oncologic outcomes in 175 patients with a median follow-up of 3 years
    Evanguelos Xylinas
    Department of Urology, Weill Cornell Medical College, New York, NY
    Urology 82:1323-9. 2013
    To report oncologic outcomes and complications after robotic-assisted radical cystectomy (RARC).
  32. doi Erythroid-extrinsic regulation of normal erythropoiesis by retinoic acid receptors
    Sita R Dewamitta
    Department of Medicine at St Vincent s Hospital, St Vincent s Institute of Medical Research, University of Melbourne, Fitzroy, Vic, Australia
    Br J Haematol 164:280-5. 2014
    ..Adult RARγ(-/-) mice were anaemic, however, Epor-Cre Rara(fl/fl) , Epor-Cre Rarg(fl/fl) and Epor-Cre Rara(fl/fl) g(fl/fl) mice were normal, indicating a lack of an erythroid intrinsic RAR function...
  33. doi Intermediate-term oncologic outcomes of robot-assisted radical cystectomy for urothelial carcinoma
    Bertram Yuh
    1 Department of Urologic Oncology, City of Hope Comprehensive Cancer Center, Duarte, California
    J Endourol 28:939-45. 2014
    To evaluate intermediate-term oncologic outcomes in a large series of patients who were treated with robot-assisted radical cystectomy (RARC) for urothelial carcinoma of the bladder (UCB).
  34. doi Effect of alvimopan on return of bowel function after robot-assisted radical cystectomy
    Scott Tobis
    City of Hope National Medical Center, Duarte, California
    J Laparoendosc Adv Surg Tech A 24:693-7. 2014
    ..The objective of this study is to determine if alvimopan has similar benefits for patients undergoing robot-assisted radical cystectomy (RARC).
  35. doi Critical role of retinoid/rexinoid signaling in mediating transformation and therapeutic response of NUP98-RARG leukemia
    J J Qiu
    1 Department of Medicine, Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA 2 Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, PA, USA
    Leukemia 29:1153-62. 2015
    While the nucleoporin 98-retinoic acid receptor gamma (NUP98-RARG) is the first RARG fusion protein found in acute leukemia, its roles and the molecular basis in oncogenic transformation are currently unknown...
  36. doi Systematic review and cumulative analysis of perioperative outcomes and complications after robot-assisted radical cystectomy
    Giacomo Novara
    Department of Surgery, Oncology, and Gastroenterology Urology Clinic, University of Padua, Italy Electronic address
    Eur Urol 67:376-401. 2015
    Although open radical cystectomy (ORC) is still the standard approach, laparoscopic radical cystectomy (LRC) and robot-assisted radical cystectomy (RARC) have gained popularity.
  37. doi Robot-assisted radical cystectomy and urinary diversion: technical recommendations from the Pasadena Consensus Panel
    Kevin G Chan
    City of Hope Cancer Center, Duarte, CA, USA Electronic address
    Eur Urol 67:423-31. 2015
    The technique of robot-assisted radical cystectomy (RARC) has evolved significantly since its inception >10 yr ago. Several high-volume centers have reported standardized techniques with refinements and subsequent outcomes.
  38. pmc Standardized analysis of complications after robot-assisted radical cystectomy: Korea University Hospital experience
    Jong Hyun Pyun
    Department of Urology, Korea University College of Medicine, Seoul, Korea
    Korean J Urol 56:48-55. 2015
    To analyze the complications after robot-assisted radical cystectomy (RARC) by use of a standardized reporting methodology by a single surgeon.
  39. doi Comparing robotic, laparoscopic and open cystectomy: a systematic review and meta-analysis
    Thomas Fonseka
    King s College London School of Medicine, London
    Arch Ital Urol Androl 87:41-8. 2015
    ..review and meta-analysis comparing outcomes between Open Radical Cystectomy (ORC), Laparoscopic Radical Cystectomy (LRC) and Robot-assisted Radical Cystectomy (RARC). RARC is to be compared to LRC and ORC and LRC compared to ORC.
  40. doi Complications from robot-assisted radical cystectomy: Where do we stand?
    I Guiote
    Servicio de Urologia, Fundacio Puigvert, Universitat Autonoma de Barcelona, Barcelona, Espana
    Actas Urol Esp 40:108-14. 2016
    ..kidney and prostate surgery have led to the progressive development of robot-assisted radical cystectomy (RARC)...
  41. doi Is robotic-assisted radical cystectomy (RARC) with intracorporeal diversion becoming the new gold standard of care?
    Hitendra R H Patel
    Department of Urology, University Hospital North Norway UNN, Tromso, Norway
    World J Urol 34:25-32. 2016
    Totally intracorporeal robotic-assisted radical cystectomy (RARC) has perceived difficulties compared to open radical cystectomy (ORC)...
  42. doi Robot-Assisted Radical Cystectomy for Bladder Cancer in Octogenarians
    Ruben De Groote
    1 Department of Urology, O L V Hospital, Aalst, Belgium
    J Endourol 30:792-8. 2016
    To evaluate perioperative morbidity and mortality rate, a 3-year recurrence-free survival, and cancer-specific mortality rate in patients older than 80 years undergoing robot-assisted radical cystectomy (RARC).
  43. doi Comparison of robotic-assisted and open radical cystectomy in a community-based, non-tertiary health care setting
    Andrew A Maes
    Metro Health Hospital, Wyoming, MI, USA
    J Robot Surg 7:359-63. 2013
    ..942 ml; p < 0.05). Regarding complications, 21 % of robotic-assisted radical cystectomy (RARC) patients experienced major complications versus 14 % of ORC patients...
  44. doi Oncological Outcomes in Patients Treated with Radical Cystectomy for Bladder Cancer: Comparison Between Open, Laparoscopic, and Robot-Assisted Approaches
    Tae Heon Kim
    1 Department of Urology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of Korea
    J Endourol 30:783-91. 2016
    To investigate oncological outcomes in patients with muscle-invasive bladder cancer who underwent open radical cystectomy (ORC), laparoscopic radical cystectomy (LRC), or robot-assisted radical cystectomy (RARC).
  45. pmc Pan-cancer analyses of the nuclear receptor superfamily
    Mark D Long
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Nucl Receptor Res 2:. 2015
    ..g. NR3C2/MR and NR5A2/LRH-1)) whereas others were uniquely down-regulated in one tumor (e.g. NR1B3/RARG)...
  46. doi National comparison of oncologic quality indicators between open and robotic-assisted radical cystectomy
    Richard S Matulewicz
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL Electronic address
    Urol Oncol 34:431.e9-431.e15. 2016
    Despite increased adoption of robotic-assisted radical cystectomy (RARC), no national data have validated its oncologic efficacy compared to the "standard" open radical cystectomy (ORC)...
  47. pmc Complications and oncologic outcomes following robot-assisted radical cystectomy: What is the real benefit?
    Dong Jae Bak
    Department of Urology, Kyungpook National University School of Medicine, Daegu, Korea
    Investig Clin Urol 57:260-7. 2016
    The aim of this study was to assess the advantages of robotic surgery, comparing perioperative and oncological outcomes between robot-assisted radical cystectomy (RARC) and open radical cystectomy (ORC).
  48. doi Contemporary evidence for robot-assisted radical cystectomy for treating bladder cancer
    Raj Satkunasivam
    Division of Urology, Department of Surgery, Sunnybrook Health Sciences Centre and University of Toronto, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    Nat Rev Urol 13:533-9. 2016
    Robot-assisted radical cystectomy (RARC) is an evolving technique for the treatment of muscle-invasive bladder cancer (MIBC); however, its effectiveness compared with open radical cystectomy (ORC) - the established modality - is debated...
  49. doi Impact of suboptimal neoadjuvant chemotherapy on peri-operative outcomes and survival after robot-assisted radical cystectomy: a multicentre multinational study
    Nobuyuki Hinata
    Roswell Park Cancer Institute, Buffalo, NY, USA
    BJU Int . 2016
    To evaluate the effect of suboptimal dosing on the outcomes of patients who received neoadjuvant chemotherapy (NAC) and robot-assisted radical cystectomy (RARC).
  50. doi Robotic Intracorporeal Padua Ileal Bladder: Surgical Technique, Perioperative, Oncologic and Functional Outcomes
    Giuseppe Simone
    Department of Urology, Regina Elena National Cancer Institute, Rome, Italy Electronic address
    Eur Urol . 2016
    Robot-assisted radical cystectomy (RARC) with intracorporeal neobladder reconstruction is a challenging procedure. The need for surgical skills and the long operative times have led to concern about its reproducibility.
  51. ncbi Preliminary results of perioperative outcomes and oncologic efficacy from a single-institution randomized controlled trial of open versus robotic-assisted radical cystectomy
    Jamie Christopher Messer
    University of Texas Health Science Center at San Antonio, San Antonio, TX
    J Clin Oncol 30:305. 2012
    ..Robotic-assisted radical cystectomy (RARC) for bladder cancer has been reported with the potential for lower blood loss, less transfusion requirement, and ..
  52. ncbi Oncologic outcomes for node-positive patients undergoing robotic radical cystectomy
    C Mmeje
    Mayo Clinic Arizona, Phoenix, AZ University of North Carolina at Chapel Hill, Chapel Hill, NC
    J Clin Oncol 29:290. 2011
    290 Background: Previous studies have shown robot assisted radical cystectomy (RARC) to have equivalent perioperative outcomes to open radical cystectomy...
  53. ncbi The feasibility and effectiveness of robot-assisted radical cystectomy after neoadjuvant chemotherapy in patients with muscle-invasive bladder cancer
    Takuya Koie
    Department of Urology, Hirosaki University Graduate School of Medicine, Aomori
    Jpn J Clin Oncol . 2016
    ..study was to compare 29 muscle-invasive bladder cancer patients who received neoadjuvant chemotherapy (NAC) followed by immediate robot-assisted radical cystectomy (RARC) with those who underwent minimum-incision endoscopic RC (MIE-RC).
  54. doi Development, validation and clinical application of Pelvic Lymphadenectomy Assessment and Completion Evaluation: intraoperative assessment of lymph node dissection after robot-assisted radical cystectomy for bladder cancer
    Ahmed A Hussein
    Department of Urology, Roswell Park Cancer Institute, Buffalo, NY, USA
    BJU Int . 2016
    ..tool, Pelvic Lymphadenectomy Appropriateness and Completion Evaluation (PLACE), to assess the intraoperative completeness and appropriateness of pelvic lymph node dissection (PLND) following robot-assisted radical cystectomy (RARC).
  55. doi Transcriptional Regulatory Network Analysis for Gastric Cancer Based on mRNA Microarray
    Yan Wang
    Department of Gastroenterology, Shengjing Hospital, China Medical University, No 36 Sanhao Road, Shenyang, 110004, China
    Pathol Oncol Res . 2017
    ..Finally, top 5 TFs including CRX, TFAP4, NKX2-1, MYB and RARG with higher ZRIF were screened...
  56. ncbi Transcriptional gene expression profiles of oesophageal adenocarcinoma and normal oesophageal tissues
    R N Hourihan
    Department of Microbiology, University College Cork, Cork, Ireland
    Anticancer Res 23:161-5. 2003
    ..activator inhibitor 2 (PAI-2), interleukin 1 receptor antagonist (IRAP), cytokeratin 13/15/17, MAD and retinoic acid receptor gamma 1 (RARG))...
  57. doi Systematic review and meta-analysis of comparative studies reporting early outcomes after robot-assisted radical cystectomy versus open radical cystectomy
    Kaiwen Li
    Department of Urology, Sun Yat Sen Memorial Hospital, Sun Yat Sen University, 107 W Yanjiang Road, Guangzhou 510020, China
    Cancer Treat Rev 39:551-60. 2013
    Robot-assisted radical cystectomy (RARC) is increasingly being used in the management of bladder cancer. Studies comparing RARC and open radical cystectomy (ORC) have reported conflicting results...
  58. pmc Status of Robot-Assisted Radical Cystectomy (RARC) in 2012
    Amrith R Rao
    Department of Urology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263 USA
    Indian J Surg Oncol 3:85-90. 2012
    Robot-assisted radical cystectomy (RARC) for bladder cancer is increasingly becoming popular in specialist centres around the world...
  59. doi Oncologic, functional, and complications outcomes of robot-assisted radical cystectomy with totally intracorporeal neobladder diversion
    Stavros I Tyritzis
    Department of Molecular Medicine and Surgery, Section of Urology, Karolinska Institutet, Stockholm, Sweden
    Eur Urol 64:734-41. 2013
    Robot-assisted radical cystectomy (RARC) with totally intracorporeal neobladder diversion is a complex procedure that has been reported with good outcomes in small series.
  60. doi Robot-assisted radical cystectomy: description of an evolved approach to radical cystectomy
    Justin W Collins
    Karolinska University Hospital, Stockholm, Sweden
    Eur Urol 64:654-63. 2013
    ..ORC) remains the gold standard of care for muscle-invasive bladder cancer, robot-assisted radical cystectomy (RARC) continues to gain wider acceptance...
  61. doi Aromatase activity induction in human adipose fibroblasts by retinoic acids via retinoic acid receptor α
    Jan Wilde
    Institute for Biochemistry II, Jena University Hospital, Friedrich Schiller University Jena, Nonnenplan 4, lt br gt 07743 Jena, Germany
    J Mol Endocrinol 51:247-60. 2013
    ..and human BAFs, RA receptor α (RARα (RARA)) expression is predominant, whereas RARβ (RARB) or RARγ (RARG) expression is low...
  62. doi Synergic effect of vitamin A and high-fat diet in adipose tissue development and nuclear receptor expression in young rats
    Anabelle Redonnet
    Unité de Nutrition et Neurosciences ISTAB, Universite Bordeaux 1, Avenue des Facultes, Talence 33405, France
    Br J Nutr 100:722-30. 2008
    ..Retinoid (retinoic acid receptor (RAR) a, RARg, retinoid X receptor(RXR) alpha) and fatty acid (PPARgamma) receptor mRNA was measured in the subcutaneous white ..
  63. doi Robotic-assisted laparoscopic radical cystectomy with extracorporeal urinary diversion: initial experience
    Declan G Murphy
    Department of Urology, Guy s and St Thomas NHS Foundation Trust, London, United Kingdom
    Eur Urol 54:570-80. 2008
    The use of robotic technology for laparoscopic prostatectomy is now well established. The same cannot yet be said of robotic-assisted laparoscopic radical cystectomy (RARC), which is performed in just a few centres worldwide.
  64. ncbi Trim24 (Tif1 alpha): an essential 'brake' for retinoic acid-induced transcription to prevent liver cancer
    Konstantin Khetchoumian
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Department of Functional Genomics, CNRS INSERM ULP, Illkirch, France
    Cell Cycle 7:3647-52. 2008
    ..to and activating nuclear RA receptors (RARs, which include the RAR alpha, beta and gamma isotypes RARA, RARB and RARC). Aberrant expression or impaired function of these nuclear receptors has been linked to diverse types of cancer...
  65. doi A NUP98-positive acute myeloid leukemia with a t(11;12)(p15;q13) without HOXC cluster gene involvement
    Roberta La Starza
    Hematology and Bone Marrow Transplantation Unit, University of Perugia, Ematologia e Trapianto di Midollo Osseo, Ospedale S M della Misericordia, Padiglione B, Piano 2, S Andrea delle Fratte, 06156 Perugia, Italy
    Cancer Genet Cytogenet 193:109-11. 2009
    ..FISH) showed that putative candidate partners mapping 600 kilobases centromeric to HOXC were RARG (retinoic acid receptor gamma), MFSD5 (major facilitator superfamily domain containing 5), and ESPL1 (extra spindle pole bodies ..
  66. ncbi [Robot-assisted laparoscopic radical cystectomy with extracorporeal urinary diversion]
    Jie Zhu
    Department of Urology, General Hospital of People s Liberation Army, Beijing 100853, China
    Zhonghua Wai Ke Za Zhi 47:1242-4. 2009
    To present the technique and experience of robotic-assisted laparoscopic radical cystectomy (RARC) by da Vinci surgical system.
  67. doi Robot assisted laparoscopic pelvic lymphadenectomy at the time of radical cystectomy rivals that of open surgery: single institution report
    Kyle A Richards
    Wake Forest University Baptist Medical Center, Department of Urology, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Urology 76:1400-4. 2010
    ..and margin status using a standard technique in the first 35 patients undergoing robot-assisted radical cystectomy (RARC) at our institution while establishing a robotics program, and then to compare the results to the past 35 open ..
  68. doi Retinoic acid receptor gamma 2 interactions with vitamin D response elements
    Nick J Koszewski
    University of Kentucky Medical Center, Division of Nephrology, Bone and Mineral Metabolism, 800 Rose Street, Lexington, KY 40536 0298, United States
    J Steroid Biochem Mol Biol 120:200-7. 2010
    ..Screening of a HeLa cell cDNA library revealed that retinoic acid receptor gamma 2 (RARgamma2) could specifically interact with VDREs, either in the presence or absence of the VDR...
  69. doi Robot-assisted radical cystectomy and pelvic lymph node dissection: a multi-institutional study from Korea
    Sung Gu Kang
    Department of Urology, Korea University Anam Hospital, Seoul, Korea
    J Endourol 24:1435-40. 2010
    To report short-term retrospective perioperative and pathologic outcomes of the first robot-assisted radical cystectomy (RARC) series in Korea.
  70. pmc Genome-wide functional screen identifies a compendium of genes affecting sensitivity to tamoxifen
    Ana M Mendes-Pereira
    Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Institute of Cancer Research, London SW3 6JB, United Kingdom
    Proc Natl Acad Sci U S A 109:2730-5. 2012
    ..of genes whose silencing causes tamoxifen resistance (including BAP1, CLPP, GPRC5D, NAE1, NF1, NIPBL, NSD1, RAD21, RARG, SMC3, and UBA3) and also a set of genes whose silencing causes sensitivity to this endocrine agent (C10orf72, ..
  71. pmc Retinoic acid drives aryl hydrocarbon receptor expression and is instrumental to dioxin-induced toxicity during palate development
    Hugues Jacobs
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Centre National de la Recherche Scientifique CNRS UMR7104, Institut National de la Santé et de la Recherche Médicale INSERM U964, Universite de Strasbourg, Illkirch, France
    Environ Health Perspect 119:1590-5. 2011
    ..Although similarities have been described between dioxin-induced toxicity and the outcome of altered atRA signaling during palate development, their relationship needs to be clarified...
  72. doi A comparison of early complications between open and robot-assisted radical cystectomy
    Hyun Hwan Sung
    Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Endourol 26:670-5. 2012
    The aim of our study was to compare early complication rates between the robot-assisted radical cystectomy (RARC) and open radical cystectomy (ORC) using a standardized reporting system.
  73. doi Is robot-assisted radical cystectomy justified in the elderly? A comparison of robotic versus open radical cystectomy for bladder cancer in elderly ≥75 years old
    Kyle A Richards
    Department of Urology, Wake Forest University Baptist Medical Center, Winston Salem, NC 27157, USA
    J Endourol 26:1301-6. 2012
    ..The objective of this study is to compare robot-assisted radical cystectomy (RARC) and ORC in elderly patients.
  74. ncbi Transcriptome network analysis reveals potential candidate genes for esophageal squamous cell carcinoma
    Zheng Ma
    Department of General Thoracic Surgery, Daping Hospital and Institute of Surgery Research, The Third Millitary Medical University, Chongqing, China
    Asian Pac J Cancer Prev 13:767-73. 2012
    ..also arose as a hub node in our transcriptome network, along with some transcription factors like CCNB1, TAP1, RARG and IFITM1 proven to be related with ESCC by previous studies...
  75. doi Standardized analysis of frequency and severity of complications after robot-assisted radical cystectomy
    Bertram E Yuh
    City of Hope National Cancer Center, Duarte, CA 90017, USA
    Eur Urol 62:806-13. 2012
    Comprehensive and standardized reporting of adverse events after robot-assisted radical cystectomy (RARC) and urinary diversion for bladder cancer is necessary to evaluate the magnitude of morbidity for this complex operation.
  76. doi Current status of robot-assisted radical cystectomy for bladder cancer
    Faris Azzouni
    Department of Urology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Nat Rev Urol 9:573-82. 2012
    ..Emerging data suggest that robot-assisted radical cystectomy (RARC) might have some advantages compared with open radical cystectomy (ORC)...
  77. ncbi Retinoid receptors in gastric cancer: expression and influence on prognosis
    Kong Wang Hu
    Department of General Surgery, The First Hospital of Anhui Medical University, School of Pharmacology, Anhui Medical University, Hefei, China
    Asian Pac J Cancer Prev 13:1809-17. 2012
    ..At present, little is known about retinoid expression and influence on prognosis in gastric cancers...
  78. doi Robot-assisted intracorporeal formation of the ileal neobladder
    Stavros I Tyritzis
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    J Endourol 26:1570-5. 2012
    We are celebrating the 10th anniversary of robot-assisted laparoscopic radical cystectomy (RARC) with urinary diversion (UD), and it seems that this operation is successfully following the footsteps of robot-assisted laparoscopic radical ..
  79. pmc Our experiences with robot-assisted laparoscopic radical cystectomy: orthotopic neobladder by the suprapubic incision method
    Byung Chul Cho
    Department of Urology, Hallym University College of Medicine, Seoul, Korea
    Korean J Urol 53:766-73. 2012
    To report our technique for and experience with robot-assisted laparoscopic radical cystectomy (RARC) with orthotopic neobladder (ON) formation in a cohort of bladder cancer patients.
  80. doi Tips and tricks to robot-assisted radical cystectomy and intracorporeal diversion
    Michael A Poch
    H Lee Moffitt Cancer Center, Tampa, Florida, USA
    Curr Opin Urol 23:65-71. 2013
    To summarize the fundamental principles for technique of robot-assisted radical cystectomy (RARC) based on current peer reviewed literature. Also provide most recent evidence for the efficacy of RARC and Intracorporeal Ileal Conduit (ICIC)...
  81. pmc Tocilizumab attenuates inflammation in ALS patients through inhibition of IL6 receptor signaling
    Mathew T Mizwicki
    Department of Surgery, David Geffen School of Medicine at UCLA 650 Charles E Young Dr South, Los Angeles, CA 90095 1735, USA
    Am J Neurodegener Dis 1:305-15. 2012
    ..just mentioned were expressed at near control levels and a significant decrease in the expression of PPARG, PPARA, RARG, HDAC4 and KAT2B; IL6R, IL6ST and ADAM17; TNFRSF11A; MGAT2 and MGAT3; PLCG1; CXCL3 were detected...
  82. doi Robotic-assisted laparoscopic radical cystectomy: history, techniques and outcomes
    Michael A Liss
    Division of Urology, Department of Surgery, UC San Diego Health System, San Diego, CA, USA
    World J Urol 31:489-97. 2013
    Robotic-assisted radical cystectomy (RARC) is a less invasive means of performing the radical cystectomy operation, which holds promise for improved patient morbidity...
  83. doi Retinoic acid receptor γ-dependent signaling cooperates with BMP2 to induce osteoblastic differentiation of C2C12 cells
    Takeo Karakida
    Department of Biochemistry, School of Dental Medicine, Tsurumi University, Yokohama, Japan
    Connect Tissue Res 52:365-72. 2011
    ..These results suggest that a RARγ-dependent functional crosstalk is present between the retinoic acid and BMP2 signaling to induce osteogenic transdifferentiation in myoblastic C2C12 cells...
  84. doi A dual-centre, cohort comparison of open, laparoscopic and robotic-assisted radical cystectomy
    M S Khan
    Urology Centre, Guy s and Thomas NHS Foundation Trust, London, UK
    Int J Clin Pract 66:656-62. 2012
    ..The role of minimally invasive radical cystectomy as opposed to open surgery for bladder cancer is not yet established. We present comparative outcomes of open, laparoscopic and robotic-assisted radical cystectomy..
  85. doi Matched comparison of robotic-assisted and open radical cystectomy
    Nicholas R Styn
    Division of Urologic Oncology, Department of Urology, University of Michigan, Ann Arbor, Michigan, USA
    Urology 79:1303-8. 2012
    To evaluate our initial robotic-assisted radical cystectomy (RARC) experience compared with a robust open radical cystectomy (ORC) series performed at a single institution using a matched-pair analysis...
  86. doi A de novo 1.13 Mb microdeletion in 12q13.13 associated with congenital distal arthrogryposis, intellectual disability and mild dysmorphism
    Dagur Ingi Jonsson
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
    Eur J Med Genet 55:437-40. 2012
    ..13 of paternal origin. The deletion contains 33 genes, including AAAS, AMRH2, and RARG genes as well as the HOXC gene cluster. At least one gene, CSAD, is expressed in fetal brain...
  87. doi Robotic versus open radical cystectomy: prospective comparison of perioperative and pathologic outcomes in Japan
    Tatsuo Gondo
    Department of Urology, Tokyo Medical University, 6 7 1 Nishi shinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Jpn J Clin Oncol 42:625-31. 2012
    In Japan, no study has compared the perioperative outcomes observed between robot-assisted radical cystectomy (RARC) and open radical cystectomy (ORC)...
  88. ncbi Surgeon controlled robot-assisted laparoscopic radical cystectomy: current review of oncologic and functional outcomes
    P L McKenzie
    Department of Urology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC, USA
    Minerva Urol Nefrol 64:79-88. 2012
    Surgeon controlled robot-assisted laparoscopic radical cystectomy (RARC) is becoming a viable treatment option for patients with muscle-invasive bladder cancer...
  89. ncbi Retinoic acid receptors as regulators of human epidermal keratinocyte differentiation
    T M Vollberg
    Cell Biology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709
    Mol Endocrinol 6:667-76. 1992
    ..This RAR-binding activity represented in part the expression of RAR alpha and RAR gamma genes, whose transcripts were expressed in similar abundance in undifferentiated NHEK...
  90. pmc RAR gamma 2 expression is regulated through a retinoic acid response element embedded in Sp1 sites
    J M Lehmann
    Cancer Center, La Jolla Cancer Research Foundation, California 92037
    Mol Cell Biol 12:2976-85. 1992
    ..Recent evidence suggests that the expression of other RAR isoforms, including that of RAR gamma 2, are also regulated by RA...
  91. ncbi The Sp1 transcription factor gene (SP1) and the 1,25-dihydroxyvitamin D3 receptor gene (VDR) are colocalized on human chromosome arm 12q and rat chromosome 7
    J Szpirer
    Departement de Biologie Moleculaire, Universite Libre de Bruxelles, Belgium
    Genomics 11:168-73. 1991
    ..The phenylalanine hydroxylase (PAH) and the retinoic acid receptor-gamma (RARG) genes also map on human chromosome arm 12q and rat chromosome 7, indicating that a synteny group is conserved on ..
  92. ncbi A functional retinoic acid receptor encoded by the gene on human chromosome 12
    T Ishikawa
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
    Mol Endocrinol 4:837-44. 1990
    ..This gene has been mapped to human chromosome 12, which is distinct from those coding for either alpha or beta RAR, and thus encodes a third human RAR...
  93. ncbi Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid
    J P Renaud
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, Strasbourg, France
    Nature 378:681-9. 1995
    ..We propose a 'mouse trap' mechanism whereby a ligand-induced conformational transition repositions the amphipathic alpha-helix of the AF-2 activating domain and forms a transcriptionally active receptor...
  94. pmc A human retinoic acid receptor gamma isoform is homologous to the murine retinoic acid receptor gamma 7
    L Zhou
    R W Johnson Pharmaceutical Research Institute, Don Mills, Ontario, Canada
    Nucleic Acids Res 21:2520. 1993
  95. ncbi Characterization of the genomic structure, chromosomal location, promoter, and development expression of the alpha-globin transcription factor CP2
    S L Swendeman
    Molecular Biology Program, Cornell University, Memorial Sloan Kettering Cancer Center, New York, New York 10021
    J Biol Chem 269:11663-71. 1994
    ..to reside on chromosome 12 while the murine gene mapped to the distal end of chromosome 15, near Gdc-1, Wnt-1, and Rarg, a region syntenic with human chromosome 12...
  96. ncbi Retinoic acid receptor/retinoid X receptor heterodimers can be activated through both subunits providing a basis for synergistic transactivation and cellular differentiation
    J Botling
    Laboratory of Tumor Biology, Department of Pathology, Uppsala University, S 751 85 Uppsala, Sweden
    J Biol Chem 272:9443-9. 1997
    ....
  97. ncbi Comparative linkage mapping of genes on sheep chromosome 3 provides evidence of chromosomal rearrangements in the evolution of the Bovidae
    Z A Jenkins
    Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Cytogenet Cell Genet 78:272-4. 1997
    Three genes--parathyroid hormone-like hormone (PTHLH), insulin-like growth factor 1 (IGF 1), and retinoic acid receptor gamma (RARG)--have been mapped to sheep (Ovis aries) chromosome 3 (OAR 3)...
  98. pmc Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2
    D Avram
    Laboratory of Molecular Pharmacology, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331 3507, USA
    J Biol Chem 274:14331-6. 1999
    ..Heterodimeric interactions between ARP1 and Ear2 may define a distinct pathway of orphan receptor signaling...
  99. ncbi Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein
    P Dowell
    Program in Molecular and Cellular Biology, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331, USA
    J Biol Chem 274:15901-7. 1999
    ..RXRalpha heterodimeric complexes in mammalian cells. NCoR appears to influence PPARalpha signaling pathways and, therefore, may modulate tissue responsiveness to peroxisome proliferators...
  100. ncbi Retinoid-dependent recruitment of a histone H1 displacement activity by retinoic acid receptor
    S Nagpal
    Retinoid Research, Allergan Inc, Irvine, California 92713, USA
    J Biol Chem 274:22563-8. 1999
    ....
  101. ncbi Retinoid-dependent antagonism of serum response factor transactivation mediated by transcriptional coactivator proteins
    S W Kim
    Center for Ligand and Transcription, Pohang University of Science and Technology, Pohang 790 784, Korea
    Oncogene 20:6638-42. 2001
    ..We propose that the well-defined anti-proliferative action of retinoids could, at least in part, result from this novel transrepressive action on the mitogenic transcription factor SRF...

Research Grants9

  1. RETINOIC ACID RECEPTOR GAMMA SPECIFIC SIGNALING IN MELAN
    REMCO SPANJAARD; Fiscal Year: 2004
    ..However, only activation of RARg by the RARg-selective agonist CD437 induces differentiation...
  2. Dipen Parekh; Fiscal Year: 2015
    ..It has been hypothesized that Robotic-Assisted Radical Cystectomy (RARC) significantly improves time to functional recovery without compromising on the oncologic effectiveness...
  3. RETINOIC ACID--ROLE IN DIFFERENTIATION
    Lorraine Gudas; Fiscal Year: 2002
    ..b>RARg is required for Hoxa1 mRNA induction by RA in these embryonic cells...
  4. RETINOIC ACID SIGNALING IN EARLY LUNG MORPHOGENESIS
    Margaret Rush; Fiscal Year: 2001
    ..1, the spatial and temporal localization of transcripts and translated proteins for CRBP1, CRABP1, RARa, RARb, and RARg will be examined by the techniques of whole mount in situ hybridization and immunohistochemistry...
  5. Retinoid Signaling in Neural Patterning in Zebrafish
    Thomas Schilling; Fiscal Year: 2009
    ..Here we will focus initially on a particular tissue interaction that requires RARg, between the mesoderm and developing neural tube, and will use cell transplantation in RAR-deficient embryos to get ..
  6. NEGATIVE REGULATION OF GENE EXPRESSION BY VITAMIN D
    NICHOLAS KOSZEWSKI; Fiscal Year: 2002
    ..abstract_text> ..
  7. TOPOISOMERASES IN RETINOID INDUCED DIFFERENTIATION
    Andrew Yen; Fiscal Year: 2003
    ..Andrew Yen, who brings expertise on the molecular and cellular biology of retinoic acid-induced myeloid differentiation. ..
  8. FLUORESCENCE ACTIVATED CELL SORTER
    Andrew Yen; Fiscal Year: 2004
    ..The instrument requested is a Dako-Cytomation basic MoFlo plus a UV-vis, vis, and HeNe laser to provide independent UV, vis/488, and red excitation. ..
  9. Retinoic Acid Regulated Cell Differentiation: BLR1 Rcptr
    Andrew Yen; Fiscal Year: 2005
    ..It has the implication that the ultimate effects of RA can be governed by relevant growth factors signaling through their cognate receptors. ..