RARA

Summary

Gene Symbol: RARA
Description: retinoic acid receptor alpha
Alias: NR1B1, RAR, retinoic acid receptor alpha, RAR-alpha, nuclear receptor subfamily 1 group B member 1, nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form, retinoic acid nuclear receptor alpha variant 1, retinoic acid nuclear receptor alpha variant 2, retinoic acid receptor, alpha polypeptide
Species: human

Top Publications

  1. pmc PU.1 is linking the glycolytic enzyme HK3 in neutrophil differentiation and survival of APL cells
    Elena A Federzoni
    Experimental Oncology Hematology, Department of Clinical Research, University of Bern, Bern, Switzerland
    Blood 119:4963-70. 2012
  2. pmc SUG-1 plays proteolytic and non-proteolytic roles in the control of retinoic acid target genes via its interaction with SRC-3
    Christine Ferry
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, Unite Mixte de Recherche 7104, Boite Postale 10142, Illkirch 67404 Cedex, CU de Strasbourg, France
    J Biol Chem 284:8127-35. 2009
  3. pmc New role for granulocyte colony-stimulating factor-induced extracellular signal-regulated kinase 1/2 in histone modification and retinoic acid receptor α recruitment to gene promoters: relevance to acute promyelocytic leukemia cell differentiation
    B Cassinat
    Inserm UMR S 940, Universite Paris Diderot, Hopital Saint Louis, 75010 Paris, France
    Mol Cell Biol 31:1409-18. 2011
  4. ncbi Interaction of BAG-1 with retinoic acid receptor and its inhibition of retinoic acid-induced apoptosis in cancer cells
    R Liu
    The Burnham Institute, Cancer Research Center, La Jolla, California 92037, USA
    J Biol Chem 273:16985-92. 1998
  5. pmc Retinoic acid (RA) regulates 17beta-hydroxysteroid dehydrogenase type 2 expression in endometrium: interaction of RA receptors with specificity protein (SP) 1/SP3 for estradiol metabolism
    You Hong Cheng
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Northwestern University, 303 E Superior Street, Chicago, IL 60611, USA
    J Clin Endocrinol Metab 93:1915-23. 2008
  6. ncbi A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors
    Y Kamei
    Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, 92093 0648, USA
    Cell 85:403-14. 1996
  7. ncbi PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator
    Rushad Pavri
    Department of Biochemistry, Howard Hughes Medical Institute, University of Medicine and Dentistry of New Jersey, 683 Hoes Lane, Piscataway, New Jersey 08854, USA
    Mol Cell 18:83-96. 2005
  8. pmc Reduced PU.1 expression causes myeloid progenitor expansion and increased leukemia penetrance in mice expressing PML-RARalpha
    Matthew J Walter
    Department of Medicine, Division of Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 102:12513-8. 2005
  9. ncbi Additional sex comb-like 1 (ASXL1), in cooperation with SRC-1, acts as a ligand-dependent coactivator for retinoic acid receptor
    Yang Sook Cho
    Department of Bioscience and Biotechnology, Institute of Bioscience, Sejong University, 98 Kunja dong, Kwangjin gu, Seoul 143 747, Korea
    J Biol Chem 281:17588-98. 2006
  10. pmc Extracellular signals regulate rapid coactivator recruitment at AP-1 sites by altered phosphorylation of both CREB binding protein and c-jun
    Linh N Tsai
    University of Illinois Cancer Center, 801 S Paulina Street, Room 530C, MC860, Chicago, IL 60612, USA
    Mol Cell Biol 28:4240-50. 2008

Research Grants

  1. Serrine S Lau; Fiscal Year: 2014
  2. Cellular Retinoic Acid Binding Proteins: Functional Studies
    Lorraine J Gudas; Fiscal Year: 2013
  3. RETINIODS AND INTERMEDIATE BIOMARKERS FOR CIN I AND II
    Mack Ruffin; Fiscal Year: 1999
  4. Yoon Kwang Lee; Fiscal Year: 2016
  5. Thiazolidinediones as Thyroid Cancer Therapy
    BRYAN HAUGEN; Fiscal Year: 2009
  6. Opoid and Retinoid Interactions in the HIV-1 Transgenic Rat
    Walter Royal; Fiscal Year: 2011
  7. Vipin Kumar; Fiscal Year: 2016
  8. Debra J Wolgemuth; Fiscal Year: 2016
  9. RETINOIC ACID RECEPTORS AND ALVEOLAR FORMATION
    JEANNE SNYDER; Fiscal Year: 2002
  10. Barbara J Meyer; Fiscal Year: 2016

Detail Information

Publications259 found, 100 shown here

  1. pmc PU.1 is linking the glycolytic enzyme HK3 in neutrophil differentiation and survival of APL cells
    Elena A Federzoni
    Experimental Oncology Hematology, Department of Clinical Research, University of Bern, Bern, Switzerland
    Blood 119:4963-70. 2012
    ..1 impaired HK3 induction during neutrophil differentiation. In vivo binding of PU.1 and PML-RARA to the HK3 promoter was found, and PML-RARA attenuated PU.1 activation of the HK3 promoter...
  2. pmc SUG-1 plays proteolytic and non-proteolytic roles in the control of retinoic acid target genes via its interaction with SRC-3
    Christine Ferry
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, Unite Mixte de Recherche 7104, Boite Postale 10142, Illkirch 67404 Cedex, CU de Strasbourg, France
    J Biol Chem 284:8127-35. 2009
    Nuclear retinoic acid receptor alpha (RARalpha) activates gene expression through dynamic interactions with coregulatory protein complexes, the assembly of which is directed by the ligand and the AF-2 domain of RARalpha...
  3. pmc New role for granulocyte colony-stimulating factor-induced extracellular signal-regulated kinase 1/2 in histone modification and retinoic acid receptor α recruitment to gene promoters: relevance to acute promyelocytic leukemia cell differentiation
    B Cassinat
    Inserm UMR S 940, Universite Paris Diderot, Hopital Saint Louis, 75010 Paris, France
    Mol Cell Biol 31:1409-18. 2011
    ..First, we show that in RA-refractory APL cells (UF-1 cell line), PML-RA receptor alpha (RARα) is not released from target promoters in response to RA, resulting in the maintenance of chromatin repression...
  4. ncbi Interaction of BAG-1 with retinoic acid receptor and its inhibition of retinoic acid-induced apoptosis in cancer cells
    R Liu
    The Burnham Institute, Cancer Research Center, La Jolla, California 92037, USA
    J Biol Chem 273:16985-92. 1998
    ..We show here that BAG-1 also interacts with retinoic acid receptor (RAR)...
  5. pmc Retinoic acid (RA) regulates 17beta-hydroxysteroid dehydrogenase type 2 expression in endometrium: interaction of RA receptors with specificity protein (SP) 1/SP3 for estradiol metabolism
    You Hong Cheng
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Northwestern University, 303 E Superior Street, Chicago, IL 60611, USA
    J Clin Endocrinol Metab 93:1915-23. 2008
    ..Retinoic acid (RA) induces HSD17B2 expression, but the underlying mechanism is not known...
  6. ncbi A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors
    Y Kamei
    Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, 92093 0648, USA
    Cell 85:403-14. 1996
    ....
  7. ncbi PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator
    Rushad Pavri
    Department of Biochemistry, Howard Hughes Medical Institute, University of Medicine and Dentistry of New Jersey, 683 Hoes Lane, Piscataway, New Jersey 08854, USA
    Mol Cell 18:83-96. 2005
    We show that PARP-1 is indispensable to retinoic acid receptor (RAR)-mediated transcription from the RARbeta2 promoter in a highly purified, reconstituted transcription system and that RA-inducible expression of all RARbeta isoforms is ..
  8. pmc Reduced PU.1 expression causes myeloid progenitor expansion and increased leukemia penetrance in mice expressing PML-RARalpha
    Matthew J Walter
    Department of Medicine, Division of Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 102:12513-8. 2005
    ..1 through a deletional mechanism, plus down-regulation of the residual allele caused by PR expression, may synergize to expand the pool of myeloid progenitors that are susceptible to transformation, increasing the penetrance of APL...
  9. ncbi Additional sex comb-like 1 (ASXL1), in cooperation with SRC-1, acts as a ligand-dependent coactivator for retinoic acid receptor
    Yang Sook Cho
    Department of Bioscience and Biotechnology, Institute of Bioscience, Sejong University, 98 Kunja dong, Kwangjin gu, Seoul 143 747, Korea
    J Biol Chem 281:17588-98. 2006
    ..a mammalian homolog of Drosophila ASX, was identified as a protein that interacts with retinoic acid receptor (RAR) in the presence of retinoic acid (RA)...
  10. pmc Extracellular signals regulate rapid coactivator recruitment at AP-1 sites by altered phosphorylation of both CREB binding protein and c-jun
    Linh N Tsai
    University of Illinois Cancer Center, 801 S Paulina Street, Room 530C, MC860, Chicago, IL 60612, USA
    Mol Cell Biol 28:4240-50. 2008
    ..The RAR interaction domains of CBP and PCAF were not required for this displacement...
  11. pmc RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2
    H Li
    Department of Pharmacology and Molecular Toxicology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655 0126, USA
    Proc Natl Acad Sci U S A 94:8479-84. 1997
    ..Thus, RAC3 is a member of a growing coactivator network that should be useful as a tool for understanding hormone action and as a target for developing new therapeutic agents that can block hormone-dependent neoplasia...
  12. ncbi The human homologue of the yeast DNA repair and TFIIH regulator MMS19 is an AF-1-specific coactivator of estrogen receptor
    X Wu
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Biol Chem 276:23962-8. 2001
    ..We find that hMMS19 stimulates the AF-1 activity of ERalpha, but not the AF-2 activity, suggesting that hMMS19 may be an AF-1-specific transcriptional coactivator of estrogen receptor...
  13. pmc Physiological and receptor-selective retinoids modulate interferon gamma signaling by increasing the expression, nuclear localization, and functional activity of interferon regulatory factor-1
    Xin M Luo
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Biol Chem 280:36228-36. 2005
    ..These results suggest that atRA, an RARalpha ligand, regulates IFNgamma-induced IRF-1 by affecting multiple components of the IFNgamma signaling pathway, from the plasma membrane to the nuclear transcription factors...
  14. ncbi TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1
    A Takeshita
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 272:27629-34. 1997
    ..These results suggest that TRAM-1 is a coactivator that may exhibit its activity by interacting with subdomains of NRs other than the AF-2 region, in contrast to SRC-1/TIF2...
  15. doi Components of the CCR4-NOT complex function as nuclear hormone receptor coactivators via association with the NRC-interacting Factor NIF-1
    Shivani Garapaty
    Department of Pharmacology and Medicine, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 283:6806-16. 2008
    ..The silencing of endogenous NIF-1 also resulted in a comparable decrease in the RAR-mediated induction of both Sox9 and HoxA1. Furthermore, CCR4 associates in vivo with NIF-1...
  16. ncbi The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR
    H De The
    Unite de Recombinaison et Expression Genetique, INSERM U 163, Institut Pasteur, Paris, France
    Cell 66:675-84. 1991
    ..the t(15;17) translocation specifically associated with acute promyelocytic leukemia (APL) fuses the retinoic acid receptor alpha (RAR alpha) locus to an as yet unknown gene, initially called myl and now renamed PML...
  17. ncbi Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor
    A J Hörlein
    Howard Hughes Medical Institute, University of California, San Diego, La Jolla 92093 0648, USA
    Nature 377:397-404. 1995
    ....
  18. ncbi A transcriptional co-repressor that interacts with nuclear hormone receptors
    J D Chen
    Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nature 377:454-7. 1995
    ..Together, our results identify a new class of cofactors which may be important mediators of hormone action...
  19. ncbi A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1
    T Perlmann
    Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden
    Genes Dev 9:769-82. 1995
    ..In this respect they are similar to heterodimers formed between RXR and the receptor for all-trans retinoic acid, RAR. However, whereas RXR is inhibited in the RXR-RAR heterodimer, NGFI-B/NURR1 promote efficient activation in ..
  20. pmc PLZF-RAR alpha fusion proteins generated from the variant t(11;17)(q23;q21) translocation in acute promyelocytic leukemia inhibit ligand-dependent transactivation of wild-type retinoic acid receptors
    Z Chen
    Shanghai Institute of Hematology, Samuel Waxman Cancer Research Foundation Laboratory of Shanghai Second Medical University, Rui Jin Hospital, China
    Proc Natl Acad Sci U S A 91:1178-82. 1994
    ..leukemia (APL) which juxtaposes PLZF, a gene encoding a zinc finger protein, to RARA, encoding retinoic acid receptor alpha (RAR alpha)...
  21. pmc Corepressor SMRT binds the BTB/POZ repressing domain of the LAZ3/BCL6 oncoprotein
    P Dhordain
    U124 Institut National de la Santé et de la Recherche Médicale, Institut de Recherches sur le Cancer de Lille Place de Verdun, F 59045 Lille Cedex France
    Proc Natl Acad Sci U S A 94:10762-7. 1997
    ..These results define SMRT as a corepressor of LAZ3/BCL6 and suggest that LAZ3/BCL6 and nuclear hormone receptors repress transcription through shared mechanisms involving SMRT recruitment and histone deacetylation...
  22. ncbi Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia
    F Grignani
    Istituto di Medicina Interna e Scienze Oncologiche, Perugia University, Italy
    Nature 391:815-8. 1998
    ..with RA induces differentiation of leukaemic blast cells and disease remission in PML-RARalpha APLs, whereas PLZF-RARa APLs are resistant to RA...
  23. ncbi Isolation and characterization of a novel coactivator protein, NCoA-62, involved in vitamin D-mediated transcription
    T A Baudino
    Department of Pharmacological and Physiological Science, Program in Cell and Molecular Biology, St Louis University Health Sciences Center, St Louis, Missouri 63104, USA
    J Biol Chem 273:16434-41. 1998
    ..These data indicate that NCoA-62 may be classified into an emerging set of transcriptional coactivator proteins that function to facilitate vitamin D- and other nuclear receptor-mediated transcriptional pathways...
  24. pmc Allosteric regulation of the discriminative responsiveness of retinoic acid receptor to natural and synthetic ligands by retinoid X receptor and DNA
    A Mouchon
    INSERM U459, faculté de médecine Henri Warembourg, 59045 Lille Cedex, France
    Mol Cell Biol 19:3073-85. 1999
    ..Conformationally restricted retinoids are used to achieve selective activation of RAR isotype alpha, beta or gamma, which reduces side effects in therapeutical applications...
  25. ncbi A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins
    S Zhong
    Department of Human Genetics, Molecular Biology Program, Memorial Sloan Kettering Cancer Center, Sloan Kettering Division, Graduate School of Medical Sciences, Cornell University, New York, New York, USA
    Nat Genet 23:287-95. 1999
    PML and Tif1a are fused to RARA and Braf, respectively, resulting in the production of PML-RARalpha and Tif1alpha-B-Raf (T18) oncoproteins...
  26. ncbi Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains
    W Bourguet
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CRNS INSERM Université Louis Pasteur Collège de France, Illkirch, Strasbourg
    Mol Cell 5:289-98. 2000
    ..Specific conformational changes suggest the structural basis of pure and partial antagonism. The RAR-RXR heterodimer interface is similar to that observed in most nuclear receptor (NR) homodimers...
  27. ncbi Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation
    S Minucci
    European Institute of Oncology, Department of Experimental Oncology, Milan, Italy
    Mol Cell 5:811-20. 2000
    b>RAR and AML1 transcription factors are found in leukemias as fusion proteins with PML and ETO, respectively...
  28. ncbi Human papilloma virus 16 E6 oncoprotein inhibits retinoic X receptor-mediated transactivation by targeting human ADA3 coactivator
    Musheng Zeng
    Division of Radiation and Cancer Biology, Department of Radiation Oncology, New England Medical Center, Boston, Massachusetts 02111, USA
    J Biol Chem 277:45611-8. 2002
    ..Significantly, we demonstrate that E6 inhibits the RXR(alpha)-mediated transactivation of target genes, implying that perturbation of RXR-mediated transactivation by E6 could contribute to HPV oncogenesis...
  29. ncbi Role of the polycomb repressive complex 2 in acute promyelocytic leukemia
    Raffaella Villa
    Centre de Regulacio Genomica, C Dr Aiguader 88, 08003 Barcelona, Spain
    Cancer Cell 11:513-25. 2007
    ..Our results demonstrate that the direct targeting of Polycomb group proteins by an oncogene plays a key role during carcinogenesis...
  30. pmc MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation
    Hye Kyung Lee
    Department of Bioscience and Biotechnology, Institute of Bioscience, Sejong University, Seoul, Korea
    EMBO J 26:3545-57. 2007
    We isolated MED25, which associates with retinoic acid (RA)-bound retinoic acid receptor (RAR) through the C-terminal nuclear hormone receptor (NR) box/LxxLL motif, and increases RAR/RXR-mediated transcription...
  31. doi Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation
    Rihab Nasr
    Université de Paris 7 CNRS UMR 7151, Equipe labellisée N degrees 11 Ligue Nationale Contre le Cancer, Service de Biochimie, Hopital St Louis, Paris Cedex 10, France
    Nat Med 14:1333-42. 2008
    ..arsenic trioxide target the protein stability and transcriptional repression activity of the fusion oncoprotein PML-RARA, resulting in regression of acute promyelocytic leukemia (APL)...
  32. pmc Genomic antagonism between retinoic acid and estrogen signaling in breast cancer
    Sujun Hua
    Institute for Genomics and Systems Biology and Department of Human Genetics, The University of Chicago, 920 East 58th Street, Chicago, IL 60637, USA
    Cell 137:1259-71. 2009
    ..To define the genetic network regulated by RARs in breast cancer, we identified RAR genomic targets using chromatin immunoprecipitation and expression analysis...
  33. pmc Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC
    Kim L Rice
    Division of Hematology Oncology, Northwestern University, Robert H Lurie Comprehensive Cancer Center, Chicago, IL, USA
    Blood 114:5499-511. 2009
    ..APL), involving the production of reciprocal fusion proteins, promyelocytic leukemia zinc finger-retinoic acid receptor alpha (PLZF-RARalpha) and RARalpha-PLZF...
  34. pmc Cooperative interaction between retinoic acid receptor-alpha and estrogen receptor in breast cancer
    Caryn S Ross-Innes
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge CB2 0RE, United Kingdom
    Genes Dev 24:171-82. 2010
    Retinoic acid receptor-alpha (RAR alpha) is a known estrogen target gene in breast cancer cells. The consequence of RAR alpha induction by estrogen was previously unknown...
  35. doi PML-RARalpha/RXR Alters the Epigenetic Landscape in Acute Promyelocytic Leukemia
    Joost H A Martens
    Department of Molecular Biology, Nijmegen Centre for Molecular Life Sciences, Radboud University, The Netherlands
    Cancer Cell 17:173-85. 2010
    ..as a local chromatin modulator and that specific recruitment of histone deacetylase activities to genes important for hematopoietic differentiation, RAR signaling, and epigenetic control is crucial to its transforming potential.
  36. doi PML/RARalpha targets promoter regions containing PU.1 consensus and RARE half sites in acute promyelocytic leukemia
    Kankan Wang
    Sino French Research Center for Life Sciences and Genomics, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, China
    Cancer Cell 17:186-97. 2010
    ..Thus, selective targeting of PU.1-regulated genes by PML/RARalpha is a critical mechanism for the pathogenesis of APL...
  37. ncbi RAR-, not RXR, ligands inhibit cell activation and prevent apoptosis in B-lymphocytes
    J Lømo
    Department of Immunology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo
    J Cell Physiol 175:68-77. 1998
    ..We found that the RAR-specific ligand TTAB reduced anti-IgM-induced B-cell activation in a dose-dependent manner...
  38. ncbi Nuclear receptor binding factor-1 (NRBF-1), a protein interacting with a wide spectrum of nuclear hormone receptors
    N Masuda
    Department of Life Science, Himeji Institute of Technology, Kamigori, Hyogo 678 1297, Japan
    Gene 221:225-33. 1998
    ..NRBF-1 has a significant homology to the yeast protein MRF1, a putative transcription factor regulating the expression of mitochondrial respiratory proteins. NRBF-1 might be another type of nuclear receptor co-operator...
  39. pmc Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation
    H J Kim
    Center for Ligand and Transcription, Chonnam National University, Kwangju 500 757, Korea
    Mol Cell Biol 19:6323-32. 1999
    ....
  40. ncbi Retinoic acid stimulation of the human surfactant protein B promoter is thyroid transcription factor 1 site-dependent
    A Naltner
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 275:56-62. 2000
    ..b>RAR coactivators ACTR, SRC-1, and transcriptional intermediary factor 2 (TIF2) stimulated human (h) SP-B promoter ..
  41. pmc Ligand-dependent interactions of coactivators steroid receptor coactivator-1 and peroxisome proliferator-activated receptor binding protein with nuclear hormone receptors can be imaged in live cells and are required for transcription
    J Llopis
    Department of Pharmacology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 97:4363-8. 2000
    ..transfected and chromosomally integrated reporter genes by the estrogen receptor (ER) and retinoic acid receptor (RAR)...
  42. pmc Potentiation of GATA-2 activity through interactions with the promyelocytic leukemia protein (PML) and the t(15;17)-generated PML-retinoic acid receptor alpha oncoprotein
    S Tsuzuki
    Section of Gene Function and Regulation, Institute of Cancer Research, London SW3 6JB, United Kingdom
    Mol Cell Biol 20:6276-86. 2000
    ..The B-box region of PML is retained in the PML-RARalpha (retinoic acid receptor alpha) fusion protein generated by the t(15;17) translocation characteristic of acute promyelocytic leukemia (..
  43. ncbi Role of MAP kinases in the 1,25-dihydroxyvitamin D3-induced transactivation of the rat cytochrome P450C24 (CYP24) promoter. Specific functions for ERK1/ERK2 and ERK5
    Prem P Dwivedi
    Department of Molecular Biosciences Biochemistry, University of Adelaide, Adelaide, Australia 5005
    J Biol Chem 277:29643-53. 2002
    ..The ERK1/ERK2 and ERK5 modules provide a novel mechanism for linking the rapid signal transduction and slower transcription actions of 1,25D to induce CYP24 gene expression...
  44. ncbi An LXXLL motif in the transactivation domain of STAT6 mediates recruitment of NCoA-1/SRC-1
    Claudia M Litterst
    Georg Speyer Haus, Institute for Biomedical Research, Paul Ehrlich Strasse 42 44, 60596 Frankfurt, Germany
    J Biol Chem 277:36052-60. 2002
    ....
  45. ncbi Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies
    Vivian Pogenberg
    Centre de Biochimie Structurale, CNRS U5048 INSERM U554 UM1, Faculte de Pharmacie, 15 Avenue Charles Flahault, 34093 Montpellier, France
    J Biol Chem 280:1625-33. 2005
    ..association between the heterodimer and the full-length SRC-1 NID is dictated by the combinatorial action of RAR and RXR ligands, the simultaneous presence of the two receptor agonists being required for highest binding affinity...
  46. ncbi Modulator recognition factor 1, an AT-rich interaction domain family member, is a novel corepressor for estrogen receptor alpha
    Serban P Georgescu
    Molecular Cardiology Research Institute, New England Medical Center and Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Mol Endocrinol 19:2491-501. 2005
    ..These data identify MRF1 as a repressor of ERalpha-mediated transcriptional activation and support a role for MRF1 in regulating ER-dependent gene expression in cardiovascular and other cells...
  47. ncbi The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling
    Mirjam T Epping
    Division of Molecular Carcinogenesis and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Cell 122:835-47. 2005
    ..acid (RA) induces proliferation arrest, differentiation, and apoptosis, and defects in retinoic acid receptor (RAR) signaling have been implicated in cancer...
  48. pmc Recruitment of the histone methyltransferase SUV39H1 and its role in the oncogenic properties of the leukemia-associated PML-retinoic acid receptor fusion protein
    Roberta Carbone
    Department of Experimental Oncology, European Institute of Oncology, and Department of Biomolecular Sciences and Biotechnologies, University of Milan, Italy
    Mol Cell Biol 26:1288-96. 2006
    ..The acute promyelocytic leukemia (APL)-associated fusion protein PML-retinoic acid receptor (RAR) behaves as an aberrant transcriptional repressor, due to its ability to induce chromatin modifications (histone ..
  49. ncbi RIF-1, a novel nuclear receptor corepressor that associates with the nuclear matrix
    Hui Joyce Li
    Molecular Cardiology Research Institute, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Cell Biochem 102:1021-35. 2007
    ..b>RAR transcriptional activities are mediated by a growing family of nuclear receptor (NR) coregulators...
  50. pmc Retinoic acid-dependent activation of the polycystic kidney disease-1 (PKD1) promoter
    M Rafiq Islam
    Dept of Biochemistry and Molecular Biology, Univ of Kansas Medical Center, MS3030, Kansas City, KS 66160, USA
    Am J Physiol Renal Physiol 295:F1845-54. 2008
    The retinoic acids all-trans retinoic acid (AT-RA) and 9-cis retinoic acid (9C-RA) and the retinoic acid receptors RAR and RXR significantly induce transcriptional activity from a 200-bp PKD1 proximal promoter in transfected mammalian ..
  51. pmc The Ski protein can inhibit ligand induced RARalpha and HDAC3 degradation in the retinoic acid signaling pathway
    Hong Ling Zhao
    Department of Molecular Genetics and Microbiology, SUNY at Stony Brook, NY 11794 5222, USA
    Biochem Biophys Res Commun 383:119-24. 2009
    ..We determined that Ski can stabilize RARalpha and HDAC3. These results suggest that Ski represses RA signaling by stabilizing corepressor complex...
  52. pmc HACE1: A novel repressor of RAR transcriptional activity
    Jianhua Zhao
    Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Cell Biochem 107:482-93. 2009
    ..In addition, HACE1 represses the endogenous RAR-regulated genes CRABP II, RIG1 and RARbeta(2), but not RAI3 in CAOV3 cells...
  53. ncbi Human Tribbles homolog 1 functions as a negative regulator of retinoic acid receptor
    Masamichi Imajo
    Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Genes Cells 15:1089-97. 2010
    ..study, we uncover a novel function of human Tribbles homolog 1 (Trib1) as a regulator of retinoic acid receptor (RAR) signaling...
  54. pmc LIM kinase 1 - dependent cofilin 1 pathway and actin dynamics mediate nuclear retinoid receptor function in T lymphocytes
    Mohammad Ishaq
    Laboratory of Molecular Cell Biology, SAIC Frederick, National Cancer Institute, Frederick, MD 21702, USA
    BMC Mol Biol 12:41. 2011
    ..Here we have investigated the role of actin dynamics and the effect of actin cytoskeleton modifying agents on retinoid receptor-mediated transactivation...
  55. ncbi Protein-protein interaction of retinoic acid receptor alpha and thyroid transcription factor-1 in respiratory epithelial cells
    C Yan
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 276:21686-91. 2001
    ..In addition, RAR and TTF-1 were colocalized in mouse bronchiolar and alveolar type II epithelial cells, the cellular site of SP-B ..
  56. pmc Akt phosphorylates and suppresses the transactivation of retinoic acid receptor alpha
    Harish Srinivas
    Department of Thoracic Head and Neck Medical Oncology, Unit 432, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Biochem J 395:653-62. 2006
    ..We previously showed that RARalpha (retinoic acid receptor alpha) phosphorylation by c-Jun N-terminal kinase contributes to retinoid resistance in a subset of NSCLC ..
  57. ncbi Fully automated determination of selective retinoic acid receptor ligands in mouse plasma and tissue by reversed-phase liquid chromatography coupled on-line with solid-phase extraction
    H M Arafa
    , , Germany
    J Chromatogr A 729:125-36. 1996
    ..assay of three retinoids (Am-580, CD-2019 and CD-437) which selectively activate the retinoic acid receptors RAR alpha, RAR beta and RAR gamma, respectively...
  58. ncbi Molecular analysis of simple variant translocations in acute promyelocytic leukemia
    J Borrow
    Somatic Cell Genetics Laboratory, Imperial Cancer Research Fund, London, UK
    Genes Chromosomes Cancer 9:234-43. 1994
    ..reciprocal translocation, t(15;17)(q22;q12), which serves to fuse the PML gene on chromosome 15 to the retinoic acid receptor alpha (RARA) gene on chromosome 17...
  59. ncbi The effect of perinatal hormonal imprinting with 13-cis-retinoic acid (isotretinoin) on the thymic glucocorticoid receptors of female and testosterone level of male adult rats
    G Csaba
    Department of Genetics, Cell and Immunobiology, Semmelweis University of Medicine, Budapest, Hungary
    Horm Metab Res 31:505-7. 1999
    ..Relationships with RAR-RXR receptor binding and teratogenicity is discussed.
  60. ncbi Molecular and metabolic retinoid pathways in the human ocular surface
    Hachemi Nezzar
    Universite d Auvergne, JE 2447, ARDEMO, France
    Mol Vis 13:1641-50. 2007
    ..activation of members of a super-family of ligand-dependant nuclear receptors that feature retinoic acid receptors (RAR) alpha, beta, and gamma as well as retinoid X receptors (RXR) alpha, beta, and gamma...
  61. ncbi Nuclear all-trans retinoic acid receptor status in rat liver: a comparison of effects of three different stressors--immobilization, laparotomy, and 2-deoxy-D-glucose
    J Brtko
    Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovak Republic
    Life Sci 66:1733-41. 2000
    ..stress (IMO), laparotomy, and 2-deoxy-D-glucose (2DG)-induced intracellular glucopenia on both nuclear RAR affinity and concentration in the rat liver...
  62. ncbi All-trans retinoic acid induces in vitro angiogenesis via retinoic acid receptor: possible involvement of paracrine effects of endogenous vascular endothelial growth factor signaling
    Akiko Saito
    Department of Medicine, Tohoku University Graduate School of Medicine, 1 1 Seiryo cho, Aoba ku, Sendai 980 8574, Japan
    Endocrinology 148:1412-23. 2007
    ..all-trans retinoic acid (ATRA) regulates a variety of important cellular functions via retinoic acid receptor (RAR). ATRA has therapeutically been used against various malignancies including acute promyelocytic leukemia...
  63. doi Running increases neurogenesis without retinoic acid receptor activation in the adult mouse dentate gyrus
    Elin Aberg
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Hippocampus 18:785-92. 2008
    ..Adult transgenic reporter mice designed to detect ligand-activated retinoic acid receptors (RAR) or retinoid X receptors (RXR) were used to localize the distribution of activated RAR or RXR at the single-cell ..
  64. ncbi Activation of retinoic acid receptor-dependent transcription by organochlorine pesticides
    Geraldine Lemaire
    Laboratoire de Pharmaco toxicologie Cellulaire et Moléculaire, Centre INRA Sophia Antipolis, 06903 Sophia Antipolis, France
    Toxicol Appl Pharmacol 202:38-49. 2005
    ..pesticides, namely, chlordane, dieldrin, aldrin, endrin, and endosulfan, activate human retinoic acid receptor (RAR)-mediated gene transcription via a retinoic acid response element (RARE)...
  65. doi Retinoic acid receptor and retinoid X receptor subtype expression for the differential diagnosis of thyroid neoplasms
    Hendrieke C Hoftijzer
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Centre, Leiden, The Netherlands
    Eur J Endocrinol 160:631-8. 2009
    Although differential expression of retinoic acid receptor (RAR) subtypes between benign and malignant thyroid tissues has been described, their diagnostic value has not been reported.
  66. ncbi Retinoic acid down-regulation of fibronectin and retinoic acid receptor alpha proteins in NIH-3T3 cells. Blocks of this response by ras transformation
    G Scita
    Laboratory of Cellular Carcinogenesis and Tumor Promotion, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 271:6502-8. 1996
    ..We identified the retinoid signal transduction pathways responsible for the effects of RA on FN and RAR alpha proteins by the use of the retinoid X receptor-selective compound, SR11237, by stable over-expression of a ..
  67. doi Expression of retinoic acid receptors in human endometrial carcinoma
    Kojiro Tanabe
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan
    Cancer Sci 99:267-71. 2008
    ..the present study, we initially studied the effects of retinoic acid on cell proliferation and the expression of RAR alpha, RAR beta, and RAR gamma using AM580 (a RAR-specific agonist) in the Ishikawa endometrial cancer cell line...
  68. ncbi Retinoic acid receptors and cellular retinoid binding proteins. I. A systematic study of their differential pattern of transcription during mouse organogenesis
    P Dolle
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Unité 184, Strasbourg, France
    Development 110:1133-51. 1990
    ..expression patterns, as revealed by in situ hybridisation, of the retinoic acid receptors alpha, beta and gamma (RAR-alpha, -beta and -gamma), and the cellular binding proteins for retinol and retinoic acid (CRBP, CRABP) in non-..
  69. ncbi Retinoic acid receptor and retinoid X receptor alterations in lung cancer precursor lesions
    N Martinet
    Centre Lorrain d Etudes et de Recherches sur les Cancers Pulmonaires, Faculte de Medecine, Vandoeuvre les Nancy, France
    Cancer Res 60:2869-75. 2000
    ..We previously reported that retinoic acid receptor (RAR) and retinoid X receptor (RXR) expression was altered in lung tumors...
  70. ncbi Existence of retinoic acid-receptor-independent retinoid X-receptor-dependent pathway in myeloid cell function
    T Hida
    Tsukuba Research Laboratories for Drug Discovery, Eisai Co, Ltd, Ibaraki, Japan
    Jpn J Pharmacol 85:60-9. 2001
    ..acid) is a potent antagonist of retinoic acid receptor (RAR), and ER-35795 ((2E,4E,6E)-7-[1-(1-methylethyl)-8-chloro-1,2,3,4-tetrahydroquinolin-6-yl]-6-fluoro-3-methyl-2,4,6-..
  71. ncbi Oestrogen and progesterone do not regulate the expression of retinoic acid receptors and retinoid 'X' receptors in human endometrial stromal cells in vitro
    M K Kumarendran
    Department of Obstetrics and Gynaecology, Medical School, University of Newcastle, Newcastle upon Tyne, UK
    Hum Reprod 9:229-34. 1994
    Elucidation of the gene structure for retinoic acid receptor-beta (RAR-beta) has suggested a potential role for oestrogen in regulating the expression of RAR-beta...
  72. ncbi Retinoic acid receptor/retinoid X receptor heterodimers can be activated through both subunits providing a basis for synergistic transactivation and cellular differentiation
    J Botling
    Laboratory of Tumor Biology, Department of Pathology, Uppsala University, S 751 85 Uppsala, Sweden
    J Biol Chem 272:9443-9. 1997
    ..RXR), forms heterodimers with several nuclear receptors, including the receptor for all-trans-retinoic acid, RAR. Previous studies have shown that retinoic acid receptor can be activated in RAR/RXR heterodimers, whereas RXR is ..
  73. ncbi Alterations in glomerular anionic sites in canine anti-glomerular basement membrane nephritis with onset of severe proteinuria
    J Sugimoto
    Mitsubishi Kasei Corporation, Research Center, School of Veterinary Medicine, Azabu University, Yokohama, Japan
    Toxicol Pathol 22:316-23. 1994
    ..On day 7 after AGBM injection, the number of PEI granules per 1,000 nm length of the lamina rara externa of GBM in all portions was significantly less than that in NRS-treated dogs (10.48 +/- 1.78 versus 14...
  74. ncbi Antiproliferative activity and apoptosis induced by retinoic acid receptor-gamma selectively binding retinoids in neuroblastoma
    B Meister
    Department of Pediatrics, University of Innsbruck, Austria
    Anticancer Res 18:1777-86. 1998
    ..In human neuroblastoma (NB) reduced endogenous RAR-gamma expression was suggested to diminish the sensitivity for retinoids, to promote proliferation, and to ..
  75. ncbi Spontaneous retinoic acid receptor beta 2 expression during mesoderm differentiation of P19 murine embryonal carcinoma cells
    M A Pratt
    Department of Cellular and Molecular Medicine, University of Ottawa, Ontario, Canada
    Differentiation 65:271-9. 2000
    ..P19 cells constitutively express the retinoic acid receptor alpha (RAR alpha) and RAR gamma mRNAs while RAR beta expression is induced by RA through a consensus RA-..
  76. ncbi The DNA-binding epidermal growth factor-receptor inhibitor PD153035 and other DNA-intercalating cytotoxic drugs reactivate the expression of the retinoic acid receptor-beta tumor-suppressor gene in breast cancer cells
    Thomas W Grunt
    Signaling Networks Program, Department of Medicine I, Division of Oncology, Medical University of Vienna, Vienna, Austria
    Differentiation 75:883-90. 2007
    ..the epidermal growth factor-receptor (EGFR) tyrosine kinase inhibitor PD153035 induces retinoic acid receptor-beta (RAR-beta) expression in malignant cells by mechanisms that are independent of its blocking activity on EGFR (ErbB1) or ..
  77. ncbi Regulation of retinoic acid receptor beta expression by peroxisome proliferator-activated receptor gamma ligands in cancer cells
    Sharon Y James
    Cancer Center, The Burnham Institute, La Jolla, California 92037, USA
    Cancer Res 63:3531-8. 2003
    ..of the PPAR gamma ligand ciglitazone and the RXR ligand SR11237 on growth and induction of retinoic acid receptor (RAR) beta expression in breast and lung cancer cells...
  78. ncbi Cellular retinol-binding protein I, a regulator of breast epithelial retinoic acid receptor activity, cell differentiation, and tumorigenicity
    Eduardo F Farias
    Department of Medicine, Mount Sinai School of Medicine, Annenberg Bldg, Rm 24 74, One Gustave L Levy Place, New York, NY 10029, USA
    J Natl Cancer Inst 97:21-9. 2005
    Retinoic acid receptor (RAR) activation induces cell differentiation and may antagonize cancer progression...
  79. ncbi Potential functions of retinoic acid receptor A in Sertoli cells and germ cells during spermatogenesis
    Timothy J Doyle
    School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4234, USA
    Ann N Y Acad Sci 1120:114-30. 2007
    ..Retinoic acid receptor A protein (RARA) is an essential mediator of retinoid signaling in the testis, as shown by a sterility phenotype observed for ..
  80. ncbi Sensitivity of human tumor cells to retinoids or combined treatment with retinoids and ionizing radiation is not dependent on RAR-beta 2 induction
    Marcel A Blaese
    Section of Radiobiology and Molecular Environmental Research, Eberhards Karls University, Tubingen, Germany
    Strahlenther Onkol 179:401-9. 2003
    The nuclear retinoic acid receptor beta 2 (RAR-beta2) is supposed to be a prognostic marker of retinoid sensitivity in patients after retinoid treatment...
  81. ncbi Retinoic acid receptors and cellular retinoid binding proteins. II. Their differential pattern of transcription during early morphogenesis in mouse embryos
    E Ruberte
    Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS Unité 184 de Biologie Moléculaire et de Génie Génétique de l INSERM, Strasbourg, France
    Development 111:45-60. 1991
    ..RNA probes was used to study the distribution of transcripts of genes coding for the retinoic acid receptors, RAR-alpha, -beta and -gamma, and the cellular binding proteins for retinoic acid (CRABP I) and retinol (CRBP I), in ..
  82. pmc Activity of retinoic acid receptor-alpha is directly regulated at its protein kinase A sites in response to follicle-stimulating hormone signaling
    Nadine C Santos
    School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4234, USA
    Endocrinology 151:2361-72. 2010
    Retinoic acid receptor-alpha (RARA) is crucial for germ cell development in the testis, as shown by the degenerated testis in Rara gene knockout mice, which are sterile...
  83. doi Hypomethylation and induction of retinoic acid receptor beta 2 by concurrent action of adenosine analogues and natural compounds in breast cancer cells
    Barbara Stefanska
    Department of Biomedical Chemistry, Medical University of Lodz, 6 8 Mazowiecka Street, 92 215 Lodz, Poland
    Eur J Pharmacol 638:47-53. 2010
    ..and 9-beta-D-arabinosyl-2-fluoroadenine (F-ara-A), on methylation and expression of retinoic acid receptor beta 2 (RAR beta 2) in MCF-7 and MDA-MB-231 breast cancer cell lines...
  84. ncbi Retinoic acid regulates gene expression of retinoic acid receptors alpha, beta and gamma in F9 mouse teratocarcinoma cells
    T C Wu
    Department of Obstetrics and Gynecology, UCLA School of Medicine 90024
    Differentiation 51:219-24. 1992
    ..The different transcripts for each RAR alpha and beta were differentially regulated by RA. The maximum induction of the 2.8 kb RAR alpha and 3...
  85. ncbi Gene expression of retinoic acid receptors and cellular retinoic acid-binding proteins in rhino and hairless mouse skin
    B C Beehler
    Dermatology Drug Discovery, Bristol Myers Squibb Pharmaceutical Research Institute, Buffalo, New York 14213, USA
    Arch Dermatol Res 287:488-93. 1995
    ..b>RAR alpha was also detected, but to a lesser degree than RAR gamma...
  86. ncbi Retinoic acid and mouse skin morphogenesis. I. Expression pattern of retinoic acid receptor genes during hair vibrissa follicle, plantar, and nasal gland development
    J P Viallet
    Laboratory of Epithelial Differentiation, University Joseph Fourier, Grenoble, France
    J Invest Dermatol 103:116-21. 1994
    The spatial and temporal expression of the nuclear retinoic acid receptors alpha, beta, and gamma (RAR-alpha, beta, and gamma) was compared by in situ hybridization during hair vibrissa follicle and nasal and plantar eccrine gland ..
  87. pmc Adenovirus E1A functions as a cofactor for retinoic acid receptor beta (RAR beta) through direct interaction with RAR beta
    G E Folkers
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht, The Netherlands
    Mol Cell Biol 15:5868-78. 1995
    ..For ligand-induced activation by the retinoic acid receptor-retinoid X receptor (RAR-RXR) heterodimer, the RAR beta 2 promoter is dependent on the presence of E1A or E1A-like activity, since this ..
  88. ncbi Differential expression of retinoic acid receptor-beta isoforms during chick limb ontogeny
    S M Smith
    Department of Nutritional Sciences, University of Wisconsin Madison 53706
    Dev Dyn 202:54-66. 1995
    ..here the cloning and characterization of three promoter- and splicing-variants of the retinoic acid receptor-beta (RAR-beta) from chick. These receptor isoforms are independently expressed during limb development...
  89. ncbi Alteration of a single amino acid residue in retinoic acid receptor causes dominant-negative phenotype
    M Saitou
    Department of Pharmacology, Kyoto University Faculty of Medicine, Japan
    J Biol Chem 269:19101-7. 1994
    Thyroid hormone receptor (TR) and retinoic acid receptor (RAR) are closely related not only in their structures but also in their modes of action...
  90. ncbi Changes of the expression and distribution of retinoic acid receptors during neurogenesis in mouse embryos
    T Yamagata
    Department of Pediatrics, Jichi Medical School, Tochigi, Japan
    Brain Res Dev Brain Res 77:163-76. 1994
    ..mRNAs and protein of RAR-beta that were expressed in the spinal cord of the 12...
  91. ncbi Different ligand responsiveness of human retinoic-acid-receptor beta-gene transcription in tumorigenic and non-tumorigenic cervical-carcinoma-derived cell lines is mediated through a large retinoic-acid-response domain
    C Baust
    German Cancer Research Center DKFZ, Heidelberg, Germany
    Int J Cancer 67:409-16. 1996
    The retinoic-acid-receptor beta gene (RAR-beta) encodes a suspected tumor suppressor for several types of human carcinomas...
  92. ncbi Cell-specific inhibition of retinoic acid receptor-alpha silencing by the AF2/tau c activation domain can be overcome by the corepressor SMRT, but not by N-CoR
    A Baniahmad
    Genetisches Institut der Justus Liebig Universitat, Giessen, Germany
    Mol Endocrinol 12:504-12. 1998
    The human retinoic acid receptor alpha (hRAR alpha) exhibits cell-specific transcriptional activity...
  93. ncbi Both retinoic acid receptors alpha (RARalpha) and gamma (RARgamma) are able to initiate mouse upper-lip skin glandular metaplasia
    S Blanchet
    Epithelial Differentiation Biology, LEDAC UMR CNRS, Albert Bonniot Institute, La Tronche, France
    J Invest Dermatol 111:206-12. 1998
    ..We therefore studied the respective roles of the RXR and RAR by treating RARalpha(-/-), beta(-/-), and gamma(-/-) skin explants with tRA and wild-type explants with synthetic ..
  94. pmc Cellular distribution of retinoic acid receptor-alpha protein in serous adenocarcinomas of ovarian, tubal, and peritoneal origin: comparison with estrogen receptor status
    C D Katsetos
    Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    Am J Pathol 153:469-80. 1998
    ..This study provides new data on the differential cellular localization of RAR alpha protein in 16 serous adenocarcinomas originating from the ovaries, fallopian tubes, and the peritoneum...
  95. ncbi Retinoic acid treatment alters the distribution of retinoic acid receptor-beta transcripts in the embryonic chick face
    A Rowe
    Department of Biochemistry, University College and Middlesex School of Medicine, London, UK
    Development 111:1007-16. 1991
    ..acid receptors in normal and abnormal chick face morphogenesis, we isolated chick retinoic acid receptor-beta (RAR-beta) cDNA clones and probed northern blots of RNA isolated from chick embryos at stages 22, 24 and 25 and from ..
  96. ncbi Function of the retinoic acid receptors (RARs) during development (II). Multiple abnormalities at various stages of organogenesis in RAR double mutants
    C Mendelsohn
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Unite 184 de Biologie Moleculaire et de Genie Genetique de l INSERM, Faculte de Medecine, Strasbourg, France
    Development 120:2749-71. 1994
    Compound null mutations of retinoic acid receptor (RAR) genes lead to lethality in utero or shortly after birth and to numerous developmental abnormalities. In the accompanying paper (Lohnes, D., Mark., M., Mendelsohn, C., Dollé, P...
  97. ncbi Control of retinoic acid receptor expression in mouse melanoma cells by cyclic AMP
    Y Xiao
    Department of Biochemistry, Boston University School of Medicine, Massachusetts 02118, USA
    J Cell Physiol 167:413-21. 1996
    Retinoic acid receptor (RAR) alpha and gamma mRNAs were constitutively expressed in B16 melanoma cells with or without retinoic acid (RA) treatment. RAR beta mRNA, however, was significantly expressed only after exposure to RA...
  98. ncbi Suppression of retinoic acid receptor beta in non-small-cell lung cancer in vivo: implications for lung cancer development
    X C Xu
    Department of Tumor Biology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    J Natl Cancer Inst 89:624-9. 1997
    ..e., retinoic acid receptors [RARs] and retinoid X receptors [RXRs]), which mediate most retinoid actions, are suppressed, abnormal activity may result that could enhance cancer development...
  99. ncbi Roles of retinoic acid receptors in early embryonic morphogenesis and hindbrain patterning
    O Wendling
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, CNRS INSERM ULP College de France, B P 163, 67404 Illkirch Cedex, C U de Strasbourg, France
    Development 128:2031-8. 2001
    ..This abnormal hindbrain phenotype is strikingly different from that of embryos lacking RAR alpha and RAR beta (A alpha/A beta mutants), in which we have previously shown that the territory corresponding to R5 ..
  100. pmc Dominant negative retinoic acid receptor initiates tumor formation in mice
    Tara S Kupumbati
    Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mol Cancer 5:12. 2006
    Retinoic acid suppresses cell growth and promotes cell differentiation, and pharmacological retinoic acid receptor (RAR) activation is anti-tumorigenic...
  101. doi Screening and detection of the in vitro agonistic activity of xenobiotics on the retinoic acid receptor
    Ryo Kamata
    Research Center for Environmental Risk, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Toxicol In Vitro 22:1050-61. 2008
    ..However, excessive embryonic exposure to specific ligands for each subtype of the RAR was reported to induce specific developmental abnormalities...

Research Grants62

  1. Serrine S Lau; Fiscal Year: 2014
    ..dose, aTRA induces Nrf2-responsive antioxidant HO-1 and NQO1 genes, as well as nuclear retinoic acid receptors RAR?, RAR?2, RAR?2, and retinoid X receptors RXR? in the kidney...
  2. Cellular Retinoic Acid Binding Proteins: Functional Studies
    Lorraine J Gudas; Fiscal Year: 2013
    ..of the individual RARs "knocked out" by homologous recombination;(b) ES cell lines with some of the "downstream" RAR target genes "knocked out";and (c) mice that have each of the individual RARs knocked out by homologous ..
  3. RETINIODS AND INTERMEDIATE BIOMARKERS FOR CIN I AND II
    Mack Ruffin; Fiscal Year: 1999
    ..genome copies of HPV per cell and inhibits HPV E6/E7 gene expression; 2) To determine if retinoic acid receptors (RAR) and/or retinoid X receptors (RXR) isoform expression change with topical atRA therapy...
  4. Yoon Kwang Lee; Fiscal Year: 2016
    ..In this new regulatory pathway, SHP represses the ability of the retinoic acid receptor (RAR) to activate expression of hairy and enhancer split 6 (Hes6) a transcriptional corepressor that has recently been ..
  5. Thiazolidinediones as Thyroid Cancer Therapy
    BRYAN HAUGEN; Fiscal Year: 2009
    ..that patients with advanced thyroid cancer would respond to retinoid therapy based on retinoic acid receptor (RAR a, b, gamma) and retinoid X receptor (RXR a, b, gamma) expression...
  6. Opoid and Retinoid Interactions in the HIV-1 Transgenic Rat
    Walter Royal; Fiscal Year: 2011
    ..The cellular effects of vitamin A are mediated by specific binding to retinoic acid receptor (RAR) and retinoid X receptor (RXR)...
  7. Vipin Kumar; Fiscal Year: 2016
    ..Sulfatide, ATRA, retinoic acid receptor-? (RAR?) or their combinations along with other inhibitory cytokines will be used to effectively treat ongoing liver ..
  8. Debra J Wolgemuth; Fiscal Year: 2016
    ..The importance of ATRA signaling via the RARa receptor in particular has been demonstrated by gene targeting in mice: RARa-deficient male mice are sterile with ..
  9. RETINOIC ACID RECEPTORS AND ALVEOLAR FORMATION
    JEANNE SNYDER; Fiscal Year: 2002
    ..RA binds to three retinoic acid receptors (RAR, i.e., RAR-alpha, -beta and -gamma...
  10. Barbara J Meyer; Fiscal Year: 2016
    ..One XSE is a nuclear hormone receptor (NHR) called SEX-1, a homolog of the retinoic acid receptor (RAR) gene family that participates in signaling pathways used for patterning and cellular differentiation in all ..
  11. Inhibition in the progression of preinvasive lung cancer by pomegranate.
    Naghma Khan; Fiscal Year: 2012
    ..for proper differentiation of lung and upper airway epithelium, and loss of expression of retinoic acid receptor (RAR)-[unreadable] is characteristic of many lung cancers...
  12. REGULATION OF PULMONARY ELASTIN PRODUCTION BY RETINOIDS
    Stephen McGowan; Fiscal Year: 2000
    ..The basal and RA- induced expression of the various retinoic acid receptor (RAR) and retinoid-X receptor (RXR) genes will be studied in cultured rat LIF and in LIF isolated from RAR-gamma null ..
  13. TRANSCRIPTIONAL REGULATION OF RETINOID ACTION
    Paul Nugent; Fiscal Year: 2000
    ..Specific aim number 1 proposes to determine, using gene knock-out mice, which, if any, of the RARs, RAR-alpha, RAR-beta or RAR-gamma, interact with RXR-alpha to mediate the teratogenic effect of retinoic acid (RA) on ..
  14. CRANIOFACIAL DEVELOPMENT--ROLE OF VITAMIN A
    Devendra Kochhar; Fiscal Year: 2000
    ..To elucidate molecular pathogenesis of developmental anomalies and to dissociate RA-dependent from RAR-independent events, we propose a new animal model more suitable for this purpose than the other approaches...
  15. Cross Regulation of Beta-catenin and Retinoid Signaling
    Stephen Byers; Fiscal Year: 2004
    ..b>Retinoic acid receptor alpha (RAR-alpha) but not retinoid X-receptor alpha (RXR-alpha) interacts directly with beta-catenin in the ..
  16. Samuel Waxman; Fiscal Year: 2015
    ..Moreover, in the human triple- negative cell lines the responsiveness to estrogen, tamoxifen and RAR agonists is restored...
  17. Noa Noy; Fiscal Year: 2015
    ..its receptors is controlled by the intracellular lipid binding proteins CRABP-II, which delivers the hormone to RAR, and FABP5, which shuttles it to PPAR?...
  18. Masahiro Iwamoto; Fiscal Year: 2016
    ..The retinoic acid receptors [unreadable], [unreadable] and [unreadable] (RAR[unreadable], RAR[unreadable] and RAR[unreadable]) are nuclear hormone receptors that regulate numerous fundamental ..
  19. Vitamin D: a link to racial disparities in birth outcomes
    Lisa M Bodnar; Fiscal Year: 2012
    ..CYP27B1), vitamin D binding protein (GC), 24- hydroxylase (CYP24A1), vitamin D receptor (VDR), and retinoic acid receptor alpha (RARA)...
  20. Vitamin A dependent events in urinary tract formation.
    Cathy Mendelsohn; Fiscal Year: 2009
    ..role of RA during prenatal and postnatal stages of papilla formation in Aim3 by expressing the dominant negative Rar receptor in the papilla and we will then analyze the effects on tubule extension and oriented mitosis...
  21. Elwood Albert Linney; Fiscal Year: 2014
    ..that has not received sufficient notice: in the absenc of retinoic acid, corepressor molecules bind to the RAR? on the RAREs, the corepresor prevents the RAR? from interacting with a coactivator and also brings in a histone ..
  22. Co-factors in HIV Mucosal Infection
    Gregory A Viglianti; Fiscal Year: 2012
    ..In addition, retinoic acid receptor (RAR) and PPAR ligands have been shown to repress HIV-1 gene expression...
  23. Novel Mucosal Adjuvant for an HIV DNA Vaccine
    Kenneth C Bagley; Fiscal Year: 2010
    ..The RA receptor (RAR) binds RA and instructs cells to up-regulate mucosal homing molecules and to become RA producers themselves...
  24. Translational Regulation of Gene Expression in Neonatal PMNs
    Christian Con Yost; Fiscal Year: 2010
    ..factor (PAF)-stimulated PMNs, translation of interleukin - 6 receptor a (IL-6Ra) and retinoic acid receptor a (RARa) mRNA transcripts is regulated in this manner...
  25. Gunda I Georg; Fiscal Year: 2016
    ..2. Retinoic Acid Receptor Alpha (RARalpha) as a Target for Male Contraception: Knockout models of RARa (Rara"'") and animal ..
  26. Mechanism of retinoic acid receptor induced innate immune responses
    Philip T Liu; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Previous studies have demonstrated that activation of the RAR results in antimicrobial activity against intracellular Mycobacterium tuberculosis...
  27. Motomi Enomoto-Iwamoto; Fiscal Year: 2014
    ..Furthermore, we found that agonists for the nuclear retinoic acid receptor ? (RAR?) stimulated tenogenic differentiation in cultured inTPCs, while they inhibited their chondrogenic differentiation ..
  28. Pier Paolo Pandolfi; Fiscal Year: 2015
    ..and epigenetic regulation of PTEN in breast cancer: We will examine the involvement of retinoic acid receptor (RAR)- and TET- dependent transcriptional and epigenetic regulation of PTEN expression in normal and pathological ..
  29. Molecular Mechanisms of Leukemogenesis by PMLRAR alpha
    Scott C Kogan; Fiscal Year: 2013
    ..leukemia (APL), one sub-type of AML, is associated with a chromosomal translocation that fuses the retinoic acid receptor alpha gene (RARA) with the gene encoding the PML nuclear protein...
  30. PMLRARalpha and PML directly regulate Fas-mediated apoptosis in vivo
    Felipe Samaniego; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The promyelocytic leukemia (PML)/retinoic acid receptor (RAR) alpha fusion protein (PMLRAR?) is at the center of regulation of receptor signaling, nuclear transcription, and cancer development...
  31. PROMYELOCYTIC ZINC FINGER GENE
    Jennifer Morris; Fiscal Year: 1999
    ..promyelocytic leukemia are characterized by a t(11;17) translocation which fuses the retinoic acid receptor-alpha (RARa) to a novel zinc finger gene, promyelocytic leukemia zinc finger gene (PLZF)...
  32. FSH and Retinoid Signaling in the Testis
    Kwan Hee Kim; Fiscal Year: 2009
    Normal spermatogenesis does not occur without functional retinoic acid receptor alpha (RAR alpha) in the testis. However, how this receptor is regulated in the testis is not known...
  33. BETA-CATENIN AND RAR INTERACT AT THE PKC ALPHA PROMOTER
    Frank Sinicrope; Fiscal Year: 2002
    ..regulators that play opposite roles during colon carcinogenesis, beta-catenin and retinoic acid receptor (RAR)...
  34. RETINOIC ACID RECEPTORS AND HEMATOPOIESIS
    Steven Collins; Fiscal Year: 2000
    ..the role of RA in hematopoiesis, the investigators have utilized retroviral vectors harboring a dominant negative RAR to interfere with normal endogenous RAR activity in different hematopoietic cells...
  35. ACTION OF RETINOIDS ON MYELOID LEUKEMIA
    H Koeffler; Fiscal Year: 1993
    ..2. The mechanism of action of retinoids is not understood. Recently, the retinoic acid receptor (RAR) cDNA has been isolated...
  36. Retinoic Acid Receptors: A Novel Therapeutic Target for Cushing's Disease
    ZACHARY BUSH; Fiscal Year: 2009
    ..Immunohistochemistry (IHC) will be performed to analyze the expression of the orphan nuclear receptors COUP-TFI, RARa, RXRa and PPAR-y in normal and adenomatous tissue...
  37. NOVEL TRANSLOCATION PRODUCT IN APL
    ROBERT REDNER; Fiscal Year: 1999
    ..models suggest that PML-RAR acts as a dominant negative for PML, a dominant negative for wild type retinoic acid receptor alpha (RARa), or a rogue transcriptional activator...
  38. The PLZF Protein of t(11;17)-Promyelocytic Leukemia
    Jonathan Licht; Fiscal Year: 2007
    ..a transcription factor, expressed in hematopoietic progenitor cells, fused to the retinoic acid receptor-alpha (RAR alpha) in t(11;17)-associated acute promyelocytic leukemia (APL)...
  39. Donna M Driscoll; Fiscal Year: 2016
    ..I is well established that RA inhibits carcinoma cell growth by activating RAR, a member of the nuclear receptor family of ligand-activated transcription factors...
  40. Retinoic Acid Paradox and Promyelocitic Leukemia
    Ethan Dmitrovsky; Fiscal Year: 2013
    ..leukemia (APL;FAB M3) has a balanced t(15;17)(q22;12-21) that rearranges theretinoic acid receptor[unreadable] (RAR[unreadable]) and promyelocytic leukemia (PML) genes...
  41. SELECTIVE RETINOIDS FOR BREAST CANCER THERAPY
    Marcia Dawson; Fiscal Year: 2002
    ..is mediated at multiple levels in their signaling pathways by the three retinoic acid and retinoid X receptor (RAR and RXR) subtypes that is compounded by their variation in cell distribution patterns and their direct and indirect ..
  42. Bruce R Blazar; Fiscal Year: 2016
    ..We show that donor T cells expressing a dominant-negative RAR-alpha (dnRAR[unreadable]) transgene have markedly impaired GVHD lethality, providing the previously unrecognized ..
  43. METABOLIC EFFECTS OF THYROID HORMONE
    Herbert Samuels; Fiscal Year: 2009
    ..Knockdown of either DBC-1, EMSY, or NIF-1 leads to a marked reduction in stimulation of Sox9, an RAR responsive gene in MCF-7 cells suggesting that the high MW NIF-1 complex plays a role in transcriptional activation ..
  44. Michael Wargovich; Fiscal Year: 2014
    ..cell lines, determine if EGCG is responsible for changes in HDACs that associate with the promoter region of RXRa, RAR[unreadable], hMLH1, p14arf, and p16INK4a and compare this activity with other known inhibitors of HDACs...
  45. Mary Kathryn Doud; Fiscal Year: 2015
    ..functions by regulating the expression of multiple genes through its ability to activate two transcription factors: RAR and PPARDELTA...
  46. Joseph L Napoli; Fiscal Year: 2014
    ..insulin secretion;2) mechanisms of rapid 9cRA actions that diminish insulin secretion;3) whether 9cRA requires RAR for non-genomic and/or genomic actions in the 2- cell;4) functions of Dhrs3 and Rdh5 in 2-cell 9cRA biosynthesis...
  47. Novel adamantyl arotinoids for the prevention and treatment of prostate cancer
    Francisco Javier Piedrafita; Fiscal Year: 2012
    ..One class of synthetic retinoid-related molecules with selective RAR activity has been described that display strong apoptotic activity in cancer cells and represent promising leads ..
  48. John S Welch; Fiscal Year: 2014
    ..Retinoid receptors RAR[unreadable] and RAR[unreadable] have been implicated in programs of hematopoietic differentiation and self-renewal, ..
  49. CAROTENOID RICH DIET TRIAL TO REVERSE CIN II
    Cheryl Rock; Fiscal Year: 1999
    ..and to determine if the regression of CIN I and II is associated with expression of retinoic acid receptors (RAR) and/or retinoid X receptors (RXR)...
  50. CAK-RARa Signaling in HSC and Leukemic Cell Commitment to Differentiation
    Lingtao Wu; Fiscal Year: 2012
    ..Our published and preliminary data indicate that subverted RARα- CAK signaling is a pivotal feature of myeloid leukemogenesis and challenges the current paradigm that RA ..
  51. Effects of Retinoic Acid and Acetaldehyde on Collagen
    Lan Wang; Fiscal Year: 2005
    ..b>RAR and RXR are known to function as heterodimers. RXR can also act independently of RAR...
  52. Retinoic acid, CRABP, and cancer
    Noa Noy; Fiscal Year: 2009
    ..that CRABP-II (but not CRABP-I) facilitates the delivery of RA to the receptor that is activated by it, namely RAR. We found further that this activity of CRABP-II enhances the transcriptional activity of RAR, suggesting that the ..
  53. Li na Wei; Fiscal Year: 2016
    ..Retinoic acid (RA), the biologically active form of vitamin A, acts, primarily, by binding to nuclear RA receptor (RAR) and retinoid receptor X (RXR) to regulate gene expression...
  54. Peilin Li; Fiscal Year: 2014
    ..acitretin is a retinoic acid, which can activate HAT. Retinoic acid (RA) receptor RAR and RXR are nuclear retinoid receptors which act as transcription factors...
  55. JAMES DOUGLAS GRIFFIN; Fiscal Year: 2016
    ..continued effort on understanding cooperation of these alleles with other leukemia associated alleles, such as PML-RARa, C/EBPa, MLL and AML1-ETO, and in developing accurate murine models of JAK2V617F MPD for testing inhibitors ..
  56. An integrative approach to target lineage-specific oncogenic transcription factor
    Ping Chi; Fiscal Year: 2012
    ..However, with the exception of ligand binding nuclear transcription factors (i.e. AR, ER, RAR[unreadable]), the majority of them are considered ""undruggable"" because they lack the conventional ""druggable"" ..
  57. Arsenic Trioxide and Acute Myeloid Leukemia
    Yongkui Jing; Fiscal Year: 2012
    ..We also showed that degradation of PML-RARa was not a crucial event in the pro-apoptotic program of As2O3, but high ROS production ability was...
  58. Abnormality in Gene Expression of Key Mediators of Vitamin A Action in COPD
    Salil K Das; Fiscal Year: 2010
    ..Microarray data also reveal a differential expression of RDH10, RDH12, RDH13, RALDH1, RALDH2, CRABP-II, CYP26A1, RAR-1, RAR-2, RAR3, and RXR-1 between these specimens...
  59. Peter K Gregersen; Fiscal Year: 2014
    ..involving transcriptional regulation through C/EBPb as well as interactions with nuclear receptors such as PPAR/RAR(7-9)...
  60. Repair of Oxidized Bases in Mammalian Genomes
    Sankar Mitra; Fiscal Year: 2012
    ..DNA replication-associated proteins led us to hypothesize a preferential role for NEIL1 and -2 in replication (RAR)- or transcription-associated repair, respectively...
  61. Gary E Landreth; Fiscal Year: 2016
    ..that HIV silencing in microglila cells can be induced by the ligand- activated nuclear receptors (LA-NR) PPAR, RAR and RXR...
  62. Jae W Lee; Fiscal Year: 2016
    ..has two objectives: 1) We will test the mechanisms of action for ASCOM in NR transactivation (primarily for FXR and RAR) by using the discoveries made during the previous funding period...