RAP2B

Summary

Gene Symbol: RAP2B
Description: RAP2B, member of RAS oncogene family
Alias: ras-related protein Rap-2b, small GTP binding protein
Species: human

Top Publications

  1. pmc Mas oncogene signaling and transformation require the small GTP-binding protein Rac
    I E Zohn
    Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill 27599 7038, USA
    Mol Cell Biol 18:1225-35. 1998
  2. ncbi Human rab11a: transcription, chromosome mapping and effect on the expression levels of host GTP-binding proteins
    P S Gromov
    Department of Medical Biochemistry and Danish Centre for Human Genome Research, Aarhus University, Denmark
    FEBS Lett 429:359-64. 1998
  3. ncbi ARF6 regulates angiotensin II type 1 receptor endocytosis by controlling the recruitment of AP-2 and clathrin
    Marie Eve Poupart
    Department of Pharmacology, School of Medicine, University of Montreal, Montreal, QC, Canada
    Cell Signal 19:2370-8. 2007
  4. pmc A bacterial Ras-like small GTP-binding protein and its cognate GAP establish a dynamic spatial polarity axis to control directed motility
    Yong Zhang
    Institut de Microbiologie de la Méditerranée Université Aix Marseille Laboratoire de Chimie Bactérienne, Marseille, France
    PLoS Biol 8:e1000430. 2010
  5. ncbi PDZ-GEF1, a guanine nucleotide exchange factor specific for Rap1 and Rap2
    J de Rooij
    Laboratory for Physiological Chemistry, Center for Biomedical Genetics, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    J Biol Chem 274:38125-30. 1999
  6. ncbi Isolation and analysis of functional homologues of the secretion-related SAR1 gene of Saccharomyces cerevisiae from Aspergillus niger and Trichoderma reesei
    G Veldhuisen
    Department of Molecular Genetics and Gene Technology, TNO Nutrition and Food Research Institute, Zeist, The Netherlands
    Mol Gen Genet 256:446-55. 1997
  7. ncbi The Gem GTP-binding protein promotes morphological differentiation in neuroblastoma
    A Leone
    Cell and Cancer Biology Department, Medicine Branch, Division of Clinical Sciences, National Cancer Institute, Building 10, Room 3B43, 9000, Rockville Pike, Bethesda, Maryland, MD 20892, USA
    Oncogene 20:3217-25. 2001
  8. doi Analysis of pulmonary vasodilator responses to the Rho-kinase inhibitor fasudil in the anesthetized rat
    Adeleke M Badejo
    Department of Pharmacology SL83, Tulane University Health Sciences Center, 1430 Tulane Ave, New Orleans, LA 70112, USA
    Am J Physiol Lung Cell Mol Physiol 295:L828-36. 2008
  9. ncbi Identification of Rab3A GTPase as an acrosome-associated small GTP-binding protein in rat sperm
    H Iida
    Faculty of Agriculture, Kyushu University, Higashi ku, Fukuoka, 812 8581, Japan
    Dev Biol 211:144-55. 1999
  10. ncbi RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG
    G Zalcman
    Unité INSERM 248, Section de Recherche, Institut Curie, 26 Rue d Ulm, 75231 Paris Cedex 05, France
    J Biol Chem 271:30366-74. 1996

Research Grants

  1. INTESTINE IN CHRONIC PORTAL HYPERTENSION
    JOSEPH BENOIT; Fiscal Year: 2004
  2. Regulation of Neuronal Survival by the Rit GTPase
    DOUGLAS ALLEN ANDRES; Fiscal Year: 2012
  3. JAMES RICHARD GOLDENRING; Fiscal Year: 2016
  4. Inorganic phosphate regulated proliferation, transformation and tumorigenesis
    George R Beck; Fiscal Year: 2013
  5. The Role of FKBP38 in tumorigenesis associated with Tsc deficiency
    Yu Jiang; Fiscal Year: 2012
  6. MARIA IRENE KONTARIDIS; Fiscal Year: 2014
  7. Ras and Phosphoinositide 3-kinase Signaling in Lens Development
    Lixing W Reneker; Fiscal Year: 2012
  8. Sympathetic Control in Heart Failure: A Role of Statins
    Irving H Zucker; Fiscal Year: 2010
  9. Chung Owyang; Fiscal Year: 2016
  10. Novel Insulin Signals Regulating GLUT4 Translocation
    Jeffrey Pessin; Fiscal Year: 2005

Detail Information

Publications181 found, 100 shown here

  1. pmc Mas oncogene signaling and transformation require the small GTP-binding protein Rac
    I E Zohn
    Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill 27599 7038, USA
    Mol Cell Biol 18:1225-35. 1998
    ..Thus, Rho family proteins are common mediators of transformation by a diverse variety of oncogene proteins that include Ras, Dbl family, and G-protein-coupled oncogene proteins...
  2. ncbi Human rab11a: transcription, chromosome mapping and effect on the expression levels of host GTP-binding proteins
    P S Gromov
    Department of Medical Biochemistry and Danish Centre for Human Genome Research, Aarhus University, Denmark
    FEBS Lett 429:359-64. 1998
    ....
  3. ncbi ARF6 regulates angiotensin II type 1 receptor endocytosis by controlling the recruitment of AP-2 and clathrin
    Marie Eve Poupart
    Department of Pharmacology, School of Medicine, University of Montreal, Montreal, QC, Canada
    Cell Signal 19:2370-8. 2007
    ..Taken together, these results suggest that the cycling of ARF6 between its GDP-and GTP-bound states coordinates the recruitment of AP-2 and clathrin to activated receptors during the endocytic process...
  4. pmc A bacterial Ras-like small GTP-binding protein and its cognate GAP establish a dynamic spatial polarity axis to control directed motility
    Yong Zhang
    Institut de Microbiologie de la Méditerranée Université Aix Marseille Laboratoire de Chimie Bactérienne, Marseille, France
    PLoS Biol 8:e1000430. 2010
    ..In summary, our results provide insight into how bacteria regulate their polarity dynamically, revealing unsuspected conserved regulations with eukaryots...
  5. ncbi PDZ-GEF1, a guanine nucleotide exchange factor specific for Rap1 and Rap2
    J de Rooij
    Laboratory for Physiological Chemistry, Center for Biomedical Genetics, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    J Biol Chem 274:38125-30. 1999
    ..This is the first example of an exchange factor acting on Rap2. We conclude that PDZ-GEF1 is a guanine nucleotide exchange factor, specific for Rap1 and Rap2, that is controlled by a negative regulatory domain...
  6. ncbi Isolation and analysis of functional homologues of the secretion-related SAR1 gene of Saccharomyces cerevisiae from Aspergillus niger and Trichoderma reesei
    G Veldhuisen
    Department of Molecular Genetics and Gene Technology, TNO Nutrition and Food Research Institute, Zeist, The Netherlands
    Mol Gen Genet 256:446-55. 1997
    ..This result contrasts with the situation in S. cerevisiae, where similar mutations have a thermosensitive phenotype. Taken together, our results indicate that the sarA gene is involved in an essential function in A. niger...
  7. ncbi The Gem GTP-binding protein promotes morphological differentiation in neuroblastoma
    A Leone
    Cell and Cancer Biology Department, Medicine Branch, Division of Clinical Sciences, National Cancer Institute, Building 10, Room 3B43, 9000, Rockville Pike, Bethesda, Maryland, MD 20892, USA
    Oncogene 20:3217-25. 2001
    ....
  8. doi Analysis of pulmonary vasodilator responses to the Rho-kinase inhibitor fasudil in the anesthetized rat
    Adeleke M Badejo
    Department of Pharmacology SL83, Tulane University Health Sciences Center, 1430 Tulane Ave, New Orleans, LA 70112, USA
    Am J Physiol Lung Cell Mol Physiol 295:L828-36. 2008
    ....
  9. ncbi Identification of Rab3A GTPase as an acrosome-associated small GTP-binding protein in rat sperm
    H Iida
    Faculty of Agriculture, Kyushu University, Higashi ku, Fukuoka, 812 8581, Japan
    Dev Biol 211:144-55. 1999
    ..In view of the putative role of Rab3A protein in membrane fusion systems, these results suggest that Rab3A could be involved in regulating the mammalian acrosome reaction by controlling the membrane fusion system in sperm...
  10. ncbi RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG
    G Zalcman
    Unité INSERM 248, Section de Recherche, Institut Curie, 26 Rue d Ulm, 75231 Paris Cedex 05, France
    J Biol Chem 271:30366-74. 1996
    ..No interaction is found with RhoA, RhoC, or Rac1 proteins. We show that GDI-3 is able to inhibit GDP/GTP exchange of RhoB and to release GDP-bound but not GTP-bound RhoB from cell membranes...
  11. ncbi Effect of protein kinase A activity on the association of ADP-ribosylation factor 1 to golgi membranes
    M E Martin
    Department of Cell Biology, University of Seville, 41012 Seville, Spain
    J Biol Chem 275:19050-9. 2000
    ..Collectively, the results show that PKA exerts a key regulatory role in the recruitment of ARF1 onto Golgi membranes. In contrast, PKA modulators did not affect recruitment of beta-COP onto Golgi membranes containing prebound ARF1...
  12. ncbi The small GTP-binding protein rho activates c-Jun N-terminal kinases/stress-activated protein kinases in human kidney 293T cells. Evidence for a Pak-independent signaling pathway
    H Teramoto
    Laboratory of Cellular Development and Oncology, NIDR, National Institutes of Health, Bethesda, Maryland 20892 4330, USA
    J Biol Chem 271:25731-4. 1996
    ....
  13. pmc Activation of the Lbc Rho exchange factor proto-oncogene by truncation of an extended C terminus that regulates transformation and targeting
    P Sterpetti
    Department of Physiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Mol Cell Biol 19:1334-45. 1999
    ..The human lbc oncogene product is a guanine nucleotide exchange factor that specifically activates the Rho small GTP binding protein, thus resulting in biologically active, GTP-bound Rho, which in turn mediates actin cytoskeletal ..
  14. pmc Regulation by Rab3A of an endogenous modulator of neurotransmitter release at mouse motor nerve endings
    Jody K Hirsh
    Department of Molecular Pharmacology and Biological Chemistry S 215, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, IL 60611, USA
    J Physiol 545:337-43. 2002
    ..CPT had no effect on the pattern of responses recorded during repetitive stimulation in either strain. The results suggest that Rab3A reduces the potency of adenosine as an endogenous mediator of neuromuscular depression...
  15. ncbi Rac1 and Toll-IL-1 receptor domain-containing adapter protein mediate Toll-like receptor 4 induction of HIV-long terminal repeat
    Ozlem Equils
    Division of Pediatric Infectious Diseases, Ahmanson Department of Pediatrics, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Room 4220, Los Angeles, CA 90048, USA
    J Immunol 172:7642-6. 2004
    ..Together these results underscore the importance of Rac1 and TIRAP in TLR4 activation of HIV replication and help delineate the signaling pathways induced by TLRs to mediate microbial Ag-induced HIV replication and HIV pathogenesis...
  16. ncbi The ras-related small GTP-binding protein RhoB is immediate-early inducible by DNA damaging treatments
    G Fritz
    Institut fur Pharmakologie und Toxikologie, Universitat des Saarlandes, Homburg Saar, Federal Republic of Germany
    J Biol Chem 270:25172-7. 1995
    ..The data indicate that rhoB represents a novel DNA damage-inducible function involved in early steps of signal transduction upon genotoxic stress...
  17. ncbi ADP-ribosylation factor-directed GTPase-activating protein. Purification and partial characterization
    V Makler
    Department of Biology, Technion Israel Institute of Technology, Haifa
    J Biol Chem 270:5232-7. 1995
    ..A., and Kahn, R. A. (1994) J. Biol. Chem. 269, 10758). The availability of the ARF GAP molecule will advance the understanding of the regulation of the cellular processes in which ARF proteins participate...
  18. ncbi PKN associates and phosphorylates the head-rod domain of neurofilament protein
    H Mukai
    Department of Biology, Faculty of Science, Kobe University, Japan
    J Biol Chem 271:9816-22. 1996
    ..The identification and characterization of the novel interaction with PKN may contribute toward the elucidation of mechanisms regulating the function of neurofilament...
  19. ncbi The small GTP-binding protein Rho1 is a multifunctional protein that regulates actin localization, cell polarity, and septum formation in the fission yeast Schizosaccharomyces pombe
    K Nakano
    Graduate Program in Biophysics and Biochemistry, School of Science, University of Tokyo, Hongo, Japan
    Genes Cells 2:679-94. 1997
    ..We have previously isolated two rho genes, rho1+ and rho2+, from the fission yeast Schizosaccharomyces pombe in order to investigate the function of Rho using genetic techniques. In this paper, we report the cellular function of Rho1...
  20. ncbi Small GTP-binding protein Ral is involved in cAMP-mediated release of von Willebrand factor from endothelial cells
    Mariska G Rondaij
    Department of Plasma Proteins, Sanquin Research at CLB, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 24:1315-20. 2004
    ..In the present study, we investigated whether Ral is also involved in cAMP-mediated vWF release...
  21. ncbi Enrichment of rab11, a small GTP-binding protein, in gastric parietal cells
    J R Goldenring
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut
    Am J Physiol 267:G187-94. 1994
    ..These results suggest that rab11 is enriched in parietal cells and is associated with intracellular tubulovesicles...
  22. ncbi Requirement for both the amino-terminal catalytic domain and a noncatalytic domain for in vivo activity of ADP-ribosylation factor GTPase-activating protein
    I Huber
    Department of Biology, Technion Israel Institute of Technology, Haifa 32000, Israel
    J Biol Chem 273:24786-91. 1998
    ..Thus, a noncatalytic domain is required for GAP activity in vivo. This domain may be involved in the targeting of GAP to the Golgi membrane...
  23. pmc An arf1Delta synthetic lethal screen identifies a new clathrin heavy chain conditional allele that perturbs vacuolar protein transport in Saccharomyces cerevisiae
    C Y Chen
    Department of Molecular Biology, Vanderbilt University, Nashville, Tennessee 37235, USA
    Genetics 150:577-89. 1998
    ....
  24. ncbi CysLT1 signal transduction in differentiated U937 cells involves the activation of the small GTP-binding protein Ras
    Valerie Capra
    Laboratory of Molecular Pharmacology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Biochem Pharmacol 67:1569-77. 2004
    ..In conclusion, LTD(4)-induced CysLT(1) receptor activation in dU937 cells leads to Ras activation and ERK phosphorylation mostly through a PTx-sensitive G(i/o) protein, PLC, and Ca(2+)-dependent tyrosine kinase(s)...
  25. pmc Ribosomal protein S6 kinase is a critical downstream effector of the target of rapamycin complex 1 for long-term facilitation in Aplysia
    Daniel B Weatherill
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada
    J Biol Chem 285:12255-67. 2010
    ..Thus, we demonstrate that S6K is an important downstream target of TORC1 in Aplysia and that it is necessary for 24-h LTF, but not for TORC1-mediated increases in somatic cap-dependent translation...
  26. ncbi The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
    A J Ridley
    Institute for Cancer Research, Chester Beatty Laboratories, London, England
    Cell 70:389-99. 1992
    ..These data imply that rho is essential specifically for the coordinated assembly of focal adhesions and stress fibers induced by growth factors...
  27. ncbi [RasGRP proteins--Ras-activating factors]
    Mateusz Szamałek
    Katedra Biochemii Farmaceutycznej, Uniwersytet Medyczny im K Marcinkowskiego, Poznan
    Postepy Biochem 53:112-20. 2007
    ..In this review, structure and function of RasGRP proteins, as well as their role in neoplastic transformation are described...
  28. ncbi Functional complementation of a yeast vesicular transport mutation ypt1-1 by a Brassica napus cDNA clone encoding a small GTP-binding protein
    Y S Park
    Department of Life Science, Pohang University of Science and Technology, Hyoja Dong, Kyungbuk, South Korea
    Plant Mol Biol 26:1725-35. 1994
    ..Genomic Southern analysis shows that this gene is a member of a small gene family in Brassica napus...
  29. pmc Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho
    T Matsui
    Division of Signal Transduction, Nara Institute of Science and Technology, Ikoma, Japan
    EMBO J 15:2208-16. 1996
    The small GTP binding protein Rho is implicated in cytoskeletal responses to extracellular signals such as lysophosphatidic acid to form stress fibers and focal contacts...
  30. ncbi Molecular characterization of an Arabidopsis thaliana cDNA encoding a small GTP-binding protein, Rha1
    S Anuntalabhochai
    Laboratorium voor Genetica, Universiteit Gent, Belgium
    Plant J 1:167-74. 1991
    ..Genomic Southern analysis revealed that rha 1 is part of a small multigene family...
  31. ncbi Gpa2p, a G-protein alpha-subunit, regulates growth and pseudohyphal development in Saccharomyces cerevisiae via a cAMP-dependent mechanism
    E Kübler
    Institut fur Mikrobiologie, Georg August Universitat Gottingen, D 37077 Gottingen, Germany
    J Biol Chem 272:20321-3. 1997
    ..Heterologous expression of mammalian G-protein alpha-subunits in these yeast GPA2 deletion strains could provide a valuable tool for the mutational analysis of mammalian G-protein function in an in vivo null setting...
  32. ncbi The small GTP-binding protein RacG regulates uroid formation in the protozoan parasite Entamoeba histolytica
    N Guillen
    Unite de Pathogenie Microbienne Moleculaire, Institut National de la Santé et de la Recherche Médicale U389 Institut Pasteur, France
    J Cell Sci 111:1729-39. 1998
    ..In addition, the number and localization of uroids were modified. These results suggest a role for EhRacG in amoebic morphogenesis and cytokinesis...
  33. pmc The retinitis pigmentosa GTPase regulator, RPGR, interacts with the delta subunit of rod cyclic GMP phosphodiesterase
    M Linari
    Max Planck Institut fur molekulare Physiologie, Abteilung Strukturelle Biologie, Rheinlanddamm 201, Postfach 102664, D 44026 Dortmund, Germany
    Proc Natl Acad Sci U S A 96:1315-20. 1999
    ..These results suggest that RPGR mutations give rise to retinal degeneration by dysregulation of intracellular processes that determine protein localization and protein transport...
  34. ncbi Rap1B and Rap2B translocation to the cytoskeleton by von Willebrand factor involves FcgammaII receptor-mediated protein tyrosine phosphorylation
    M Torti
    Department of Biochemistry, University of Pavia, via Bassi 21, 27100 Pavia, Italy
    J Biol Chem 274:13690-7. 1999
    ..of human platelets with von Willebrand factor (vWF) induced the translocation of the small GTPases Rap1B and Rap2B to the cytoskeleton...
  35. pmc The golgi-associated COPI-coated buds and vesicles contain beta/gamma -actin
    F Valderrama
    Departament de Biologia Cellular, Facultat de Medicina, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Universitat de Barcelona, 08036 Barcelona, Spain
    Proc Natl Acad Sci U S A 97:1560-5. 2000
    ....
  36. ncbi Molecular cloning of a cDNA for a small GTP binding protein, BRho, from the embryo of Bombyx mori and its characterization after expression and purification
    T Uno
    Laboratory of Biological Chemistry, Department of Biofunctional Chemistry, Faculty of Agriculture, Kobe University, Nada Ku, Kobe, Hyogo, Japan
    Arch Insect Biochem Physiol 43:165-72. 2000
    A cDNA clone encoding a small GTP binding protein (Brho) was isolated from an embryonic cDNA library of Bombyx mori that encoded a polypeptide with 202 amino acids sharing 60-80% similarity with the Rho1 family of GTP binding proteins...
  37. ncbi Plant RanGAPs are localized at the nuclear envelope in interphase and associated with microtubules in mitotic cells
    Aniko Pay
    Plant Biology Institute, Biological Research Center, H 6701 Szeged, PO Box 521, Hungary
    Plant J 30:699-709. 2002
    ....
  38. pmc The domain architecture of large guanine nucleotide exchange factors for the small GTP-binding protein Arf
    Barbara Mouratou
    Laboratoire d Enzymologie et Biochimie Structurales, CNRS, Avenue de la Terrasse, 91198 Gif sur Yvette Cedex, France
    BMC Genomics 6:20. 2005
    ..In contrast, the function of non-catalytic domains and how they regulate/cooperate with the catalytic domain is essentially unknown...
  39. ncbi Centaurin-alpha 1, an ADP-ribosylation factor 6 GTPase activating protein, inhibits beta 2-adrenoceptor internalization
    Joanna Lawrence
    Department of Pharmacology, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, United Kingdom
    Mol Pharmacol 67:1822-8. 2005
    ..Thus, ARF6 GAPs, such as centaurin alpha(1), are likely to play a crucial role in GPCR trafficking by modulating the activity of ARF6...
  40. ncbi Nuclear localization of endogenous RGK proteins and modulation of cell shape remodeling by regulated nuclear transport
    Ramasubbu N Mahalakshmi
    Epithelial Cell Biology Laboratory, Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673, Singapore
    Traffic 8:1164-78. 2007
    ..e., cytoskeleton, endoplasmic reticulum or plasma membrane) is of physiological relevance for the regulation of RGK protein function...
  41. doi Role of inducible nitric oxide synthase in induction of RhoA expression in hearts from diabetic rats
    Hesham Soliman
    Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of British Columbia, 2146 East Mall, Vancouver, BC, Canada V6T 1Z3
    Cardiovasc Res 79:322-30. 2008
    ..Therefore, in this study, we investigated the hypothesis that induction of iNOS positively regulates RhoA expression in diabetic rat hearts...
  42. pmc In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase
    M Ren
    Department of Cell Biology, New York University School of Medicine, New York, 10016, USA
    Proc Natl Acad Sci U S A 93:5151-5. 1996
    ..Moreover, the rab8ip/GC kinase may serve to modulate secretion in response to stress stimuli...
  43. pmc Ethanol-induced retention of nascent proteins in rat hepatocytes is accompanied by altered distribution of the small GTP-binding protein rab2
    J M Larkin
    Center for Basic Research in Digestive Diseases, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Clin Invest 98:2146-57. 1996
    ..The effects of ethanol exposure on rab proteins and Golgi function are discussed...
  44. ncbi Increased immunoreactivity for Rab11, a small GTP-binding protein, in low-grade dysplastic Barrett's epithelia
    G S Ray
    Department of Medicine, Institute for Molecular Medicine and Genetics, Medical College of Georgia, Augusta 30912 3175, USA
    Lab Invest 77:503-11. 1997
    ....
  45. ncbi The small GTP-binding protein Rac promotes the dissociation of gelsolin from actin filaments in neutrophils
    A Arcaro
    Institute of Biochemistry, University of Fribourg, CH 1700 Fribourg, Switzerland
    J Biol Chem 273:805-13. 1998
    ..These findings suggest that activation of Rac by G-protein-coupled receptors in neutrophils triggers uncapping of actin filaments, independently of PI 3-kinase...
  46. ncbi Regulation of RhoA GTP hydrolysis by the GTPase-activating proteins p190, p50RhoGAP, Bcr, and 3BP-1
    B Zhang
    Department of Biochemistry, University of Tennessee, Memphis, Tennessee 38163, USA
    Biochemistry 37:5249-57. 1998
    ....
  47. ncbi Characterization of a desiccation-responsive small GTP-binding protein (Rab2) from the desiccation-tolerant grass Sporobolus stapfianus
    M J Oliver
    Plant Stress and Water Conservation Laboratory, USDA ARS, Lubbock, TX 79401, USA
    Plant Mol Biol 39:809-21. 1999
    ..A possible role for Rab2 with respect to desiccation tolerance and damage repair is discussed...
  48. pmc Characterization of the Rac-GAP (Rac-GTPase-activating protein) activity of beta2-chimaerin, a 'non-protein kinase C' phorbol ester receptor
    Maria Jose Caloca
    Center for Experimental Therapeutics and Department of Pharmacology, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104 6160, USA
    Biochem J 375:313-21. 2003
    ..These results strongly emphasize the high complexity of DAG signalling due to the activation of PKC-independent pathways, and cast doubts regarding the selectivity of phorbol esters and DAG analogues as selective PKC activators...
  49. ncbi Identification and biochemical characterization of Rap2C, a new member of the Rap family of small GTP-binding proteins
    Simona Paganini
    Center of Excellence for Applied Biology, Department of Biochemistry, University of Pavia, via Bassi 21, 27100 Pavia, Italy
    Biochimie 88:285-95. 2006
    The Rap family of small GTP-binding proteins is composed by four different members: Rap1A, Rap1B, Rap2A and Rap2B. In this work we report the identification and characterization of a fifth member of this family of small GTPases...
  50. ncbi Molecular characterization of a rab-related small GTP binding protein cDNA from rice (Oryza sativa L. IR-36)
    H Y Kim
    Plant Molecular Biology and Biotechnology Research Center, Gyeongsang National University, Chinju, Korea
    Mol Cells 7:226-30. 1997
    ..roles of plant small GTP binding proteins, we isolated a cDNA clone (ORrab2) encoding the rab-related small GTP binding protein from rice (Oryza sativa L. IR-36) by using human cDNA rab2 as a probe...
  51. ncbi Rab3D, a small GTP-binding protein implicated in regulated secretion, is associated with the transcytotic pathway in rat hepatocytes
    J M Larkin
    Barnard College, Department of Biological Sciences, New York, NY, USA
    Hepatology 32:348-56. 2000
    ..Our results indicate that rab3D plays a role in the regulation of apically directed transcytosis in rat hepatocytes...
  52. pmc C terminus of the small GTP-binding protein smg p25A contains two geranylgeranylated cysteine residues and a methyl ester
    C C Farnsworth
    Howard Hughes Medical Institute Laboratory, University of Washington, Seattle, WA 98195
    Proc Natl Acad Sci U S A 88:6196-200. 1991
    ....
  53. pmc Structural and functional dissection of a membrane glycoprotein required for vesicle budding from the endoplasmic reticulum
    C d'Enfert
    Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, University of California, Berkeley 94720
    Mol Cell Biol 11:5727-34. 1991
    ..Sar1p membrane association was enhanced by elevated levels of Sec12p. These results suggest that the cytoplasmic domain of Sec12p interacts with Sar1p and that the complex may function to promote vesicle formation...
  54. ncbi BUD2 encodes a GTPase-activating protein for Bud1/Rsr1 necessary for proper bud-site selection in yeast
    H O Park
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143 0448
    Nature 365:269-74. 1993
    ..Chromosomal deletion of BUD2 causes a random budding pattern but no obvious growth defect. Overexpression of BUD2 also causes a random budding pattern by wild-type cells...
  55. ncbi Purification and characterization of SAR1p, a small GTP-binding protein required for transport vesicle formation from the endoplasmic reticulum
    C Barlowe
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720
    J Biol Chem 268:873-9. 1993
    ..Sar1p prebound with GTP gamma S inhibits Sar1p function in the vesicle formation assay. The results indicate a role for Sar1p in vesicle budding from the ER and suggest that GTP hydrolysis by Sar1p is required for this event...
  56. ncbi Molecular characterization of rgp2, a gene encoding a small GTP-binding protein from rice
    S Youssefian
    Laboratory of Molecular Genetics, Akita Prefectural College of Agriculture, Japan
    Mol Gen Genet 237:187-92. 1993
    ..Southern blot analysis suggests that, in addition to rgp1 and rgp2, several other homologues exist in rice and these may constitute a small multigene family...
  57. ncbi DGAP1, a homologue of rasGTPase activating proteins that controls growth, cytokinesis, and development in Dictyostelium discoideum
    J Faix
    Max Planck Institut fur Biochemie, Martinsried, Germany
    FEBS Lett 394:251-7. 1996
    ..discoideum, ras or a related small GTP-binding protein is involved in regulating growth based on the phagocytosis of bacteria, and in coupling activities of the cell cortex to the organization of spindle and asters in mitotic cells...
  58. pmc Functional characterization of the Cdc42p binding domain of yeast Ste20p protein kinase
    E Leberer
    Eukaryotic Genetics Group, Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec
    EMBO J 16:83-97. 1997
    ..roles in pheromone signaling, morphological switching and vegetative growth and binds Cdc42p, a Rho-like small GTP binding protein required for polarized morphogenesis...
  59. ncbi Suppression of integrin activation: a novel function of a Ras/Raf-initiated MAP kinase pathway
    P E Hughes
    Department of Vascular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Cell 88:521-30. 1997
    ..Thus, regulation of integrin affinity state is a novel, transcription-independent function of a Ras-linked MAP kinase pathway that may mediate a negative feedback loop in integrin function...
  60. ncbi Cloning, expression, and characterization of a novel phospholipase D complementary DNA from rat brain
    T Kodaki
    Department of Biochemistry, Gunma University School of Medicine, Maebashi 371, Japan
    J Biol Chem 272:11408-13. 1997
    ..Only a negligible level was found in spleen and pancreas. Thus rPLD2 is a novel type of PLD dependent on phosphatidylinositol 4,5-bisphosphate, but not on the small GTP-binding proteins ADP-ribosylation factor 1 and RhoA...
  61. ncbi Cloning and chromosome assignment to 1q32 of a human cDNA (RAB7L1) encoding a small GTP-binding protein, a member of the RAS superfamily
    F Shimizu
    Otsuka GEN Research Institute, Otsuka Pharmaceutical Co, Ltd, Tokushima, Japan
    Cytogenet Cell Genet 77:261-3. 1997
    ..This gene was located on chromosome band 1q32 by fluorescence in situ hybridization...
  62. ncbi Genes that cause aberrant cell morphology by overexpression in fission yeast: a role of a small GTP-binding protein Rho2 in cell morphogenesis
    D Hirata
    Department of Molecular Biotechnology, Graduate School of Engineering, Hiroshima University, Higashi Hiroshima 739, Japan
    J Cell Sci 111:149-59. 1998
    ..Analysis of functional overlapping between Rho2 and Rho1 revealed that their functions are distinct from each other, with partial overlapping...
  63. ncbi Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity
    A Arcaro
    Ludwig Institute for Cancer Research, University College, London W1P 8BT, United Kingdom
    J Biol Chem 273:33082-90. 1998
    ..Although presently it is not known whether PI 3-kinase C2beta is regulated by Ca2+ in vivo, our results suggest a novel role for Ca2+ ions in phosphate transfer reactions...
  64. ncbi Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP
    N Nassar
    Department of Pharmacology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    Nat Struct Biol 5:1047-52. 1998
    ..Comparison of the structures for the wild type and mutant Cdc42GAP complexes provides important insights into the GAP-catalyzed GTP hydrolytic reaction...
  65. ncbi A conserved small GTP-binding protein Alp41 is essential for the cofactor-dependent biogenesis of microtubules in fission yeast
    P A Radcliffe
    Laboratory of Cell Regulation, Imperial Cancer Research Fund, P O Box 123, 44 Lincoln s Inn Fields, London, UK
    FEBS Lett 468:84-8. 2000
    ..Genetic analysis indicates that Alp41 plays a crucial role in the cofactor-dependent pathway, in which it functions upstream of the cofactor D homologue Alp1(D) and possibly in concert with Alp21(E)...
  66. pmc TRAPP stimulates guanine nucleotide exchange on Ypt1p
    W Wang
    Howard Hughes Medical Institute and the Department of Cell Biology Yale University School of Medicine, New Haven, Connecticut 06519 1418, USA
    J Cell Biol 151:289-96. 2000
    ..Furthermore, the purified TRAPP complex accelerates nucleotide exchange on Ypt1p. Our findings imply that Ypt1p, which is present on ER-to-Golgi transport vesicles, is activated at the Golgi once it interacts with TRAPP...
  67. ncbi beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis
    A Claing
    Howard Hughes Medical Institute and Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 276:42509-13. 2001
    ....
  68. ncbi Filopodia are conduits for melanosome transfer to keratinocytes
    Glynis Scott
    Department of Dermatology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    J Cell Sci 115:1441-51. 2002
    ....
  69. ncbi Phenotypic changes associated with exogenous expression of p16INK4a in human glioma cells
    A Noguchi
    Department of Neurosurgery, Kyorin University School of Medicine, Mitaka, Tokyo, Japan
    Brain Tumor Pathol 18:73-81. 2001
    ....
  70. ncbi Ras participates in CpG oligodeoxynucleotide signaling through association with toll-like receptor 9 and promotion of interleukin-1 receptor-associated kinase/tumor necrosis factor receptor-associated factor 6 complex formation in macrophages
    Hongmei Xu
    Institute of Immunology, Second Military Medical University, Shanghai 200433, People s Republic of China
    J Biol Chem 278:36334-40. 2003
    ....
  71. ncbi Requirement for Arf6 in cell adhesion, migration, and cancer cell invasion
    Hisataka Sabe
    Department of Molecular Biology, Osaka Bioscience Institute, Osaka 565 0874
    J Biochem 134:485-9. 2003
    ..Here the possible roles of a small GTP-binding protein, Arf6, in epithelial cell adhesion and migration, and also in cancer cell invasion, are discussed...
  72. pmc Rhes is involved in striatal function
    Daniela Spano
    Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy
    Mol Cell Biol 24:5788-96. 2004
    ..These results suggest that Rhes disruption affects selected behavioral competencies...
  73. ncbi A Rab-related small GTP binding protein is predominantly expressed in root nodules of Medicago sativa
    K Schiene
    Biologie Genetik, Universitat Bielefeld, Postfach 100 131, 33501 Bielefeld, Germany
    Mol Genet Genomics 272:57-66. 2004
    ..Using the cDNA-sequence of MS-rab11f, a peptide-specific antibody was generated. Western blot analysis with this antibody revealed that two Rab11F isoforms, designated MS-Rab11FA and MS-Rab11FB, are found in M. sativa root nodules...
  74. ncbi Role of beta2-chimaerin in the behaviour of murine mammary carcinoma cells in response to extracellular matrix components
    Pablo Lorenzano Menna
    Laboratory of Molecular Oncology, Quilmes National University, Buenos Aires, Argentina
    Int J Mol Med 15:91-5. 2005
    ..The restitution of normal Rac levels by beta2-chimaerin activity induced an increase in the sensitivity of tumour cells to extracellular factors, suggesting a regression of the malignant phenotype...
  75. ncbi Small GTP-binding protein RhoB is expressed in glial Müller cells in the vertebrate retina
    Andréa Silveira Santos-Bredariol
    Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP 05508 900, Brazil
    J Comp Neurol 494:976-85. 2006
    ..In addition, we show that RhoB may be an interesting Müller cell marker in the adult retina...
  76. pmc Transcriptional signatures of cellular plasticity in mice lacking the alpha1 subunit of GABAA receptors
    Igor Ponomarev
    Waggoner Center for Alcohol and Addiction Research, University of Texas, Austin, Texas 78712, USA
    J Neurosci 26:5673-83. 2006
    ..observed in the knock-out mice and suggested several genes, such as the early growth response 1 (Egr1), small GTP binding protein Rac1 (Rac1), neurogranin (Nrgn), sodium channel beta4 subunit (Scn4b), and potassium voltage-gated Kv4...
  77. ncbi Flagellin and lipopolysaccharide stimulate the MEK-ERK signaling pathway in chicken heterophils through differential activation of the small GTPases, Ras and Rap1
    M H Kogut
    Laboratory of Avian Innate Immunity, USDA ARS, Southern Plains Agricultural Research Center, 2881 F and B Road, College Station, TX 77845, USA
    Mol Immunol 44:1729-36. 2007
    ....
  78. ncbi Nuclear transport of Kir/Gem requires specific signals and importin alpha5 and is regulated by calmodulin and predicted serine phosphorylations
    Ramasubbu N Mahalakshmi
    Epithelial Cell Biology Laboratory, Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673, Singapore
    Traffic 8:1150-63. 2007
    ..Nuclear localization of endogenous RGK proteins and modulation of cell shape remodeling by regulated nuclear transport. Traffic 2007; doi:10.1111/j.1600-0854.2007.00599.x), interfere with cell-shape remodeling...
  79. doi Altered cellular immunity in transgenic mice with T cell-specific expression of human D4-guanine diphosphate-dissociation inhibitor (D4-GDI)
    Kensuke Kondoh
    Department of Pathology, Keio University School of Medicine, Shinjuku ku, Tokyo 160 8582, Japan
    Int Immunol 20:1299-311. 2008
    ..D4-GDI may have important functions, such as induction of T cell migration, adhesion and/or proliferation in inflammatory foci, in cellular immunity responses to cytozoic pathogens...
  80. pmc Specificity of interactions between mDia isoforms and Rho proteins
    Michael Lammers
    Max Planck Institute for Molecular Physiology, Department of Structural Biology, Otto Hahn Strasse 11, 44227 Dortmund, Germany
    J Biol Chem 283:35236-46. 2008
    ..We also show that the F106H and H104F mutations drastically alter the affinities and thermodynamics of mDia interactions...
  81. doi Investigation of the role of oligopeptide transporter PEPT1 and sodium/glucose cotransporter SGLT1 in intestinal absorption of their substrates using small GTP-binding protein Rab8-null mice
    Yukio Kato
    Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
    Drug Metab Dispos 37:602-7. 2009
    ..The present findings also illustrate the pharmacokinetic influence of the sorting machinery protein Rab8...
  82. pmc ARF6-mediated endosome recycling reverses lipid accumulation defects in Niemann-Pick Type C disease
    Jill Kuglin Schweitzer
    Department of Biological Sciences and the Center for Rare and Neglected Diseases, University of Notre Dame, Notre Dame, Indiana, United States of America
    PLoS ONE 4:e5193. 2009
    ....
  83. doi Inferring the functional effects of mutation through clusters of mutations in homologous proteins
    Peng Yue
    Department of Bioinformatics, Genentech Inc, South San Francisco, California 94080, USA
    Hum Mutat 31:264-71. 2010
    ..mutations suggests functional impact for many, including singleton mutations in FGFR1, FGFR3, GFI1B, PIK3CG, RALB, RAP2B, and STK11...
  84. pmc Small GTP-binding protein Ran is regulated by posttranslational lysine acetylation
    Susanne de Boor
    Institute for Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, University of Cologne, 50931 Cologne, Germany
    Proc Natl Acad Sci U S A 112:E3679-88. 2015
    ..Moreover, Ran was acetylated by CBP/p300 and Tip60 in vitro and on transferase overexpression in vivo. Overall, this study addresses many important challenges of the acetylome field, which will be discussed. ..
  85. doi Expression and DNA methylation status of the Rap2B gene in human bronchial epithelial cells treated by cigarette smoke condensate
    Shuangling Zhang
    a School of Public Health, Medical College, Wuhan University of Science and Technology, Wuhan, China
    Inhal Toxicol 27:502-9. 2015
    The relationship between lung cancer and smoking has been demonstrated. The Rap2B gene is usually overexpressed in lung cancers...
  86. pmc The GTPase ARF6 Controls ROS Production to Mediate Angiotensin II-Induced Vascular Smooth Muscle Cell Proliferation
    Mohamed Bourmoum
    Department of Pharmacology, Faculty of Medicine, Universite de Montreal, Montreal, Quebec, H3T 1J4, Canada
    PLoS ONE 11:e0148097. 2016
    ..In turn, increased ROS acts to activate the MAPK pathway. These signaling events represent a new molecular mechanism by which Ang II can promote proliferation of VSMC. ..
  87. ncbi Characterization and subcellular localization of a small GTP-binding protein (Ara-4) from Arabidopsis: conditional expression under control of the promoter of the gene for heat-shock protein HSP81-1
    T Ueda
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan
    Mol Gen Genet 250:533-9. 1996
    ..Using transgenic plants, we determined the subcellular localization of the product of ARA-4. The protein was predominantly localized on Golgi-derived vesicles, Golgi cisternae and the trans-Golgi network...
  88. ncbi Physical and functional interaction of rabphilin-3A with alpha-actinin
    M Kato
    Department of Molecular Biology and Biochemistry, Osaka University Medical School, Suita 565, Osaka, Japan
    J Biol Chem 271:31775-8. 1996
    ..It has been shown that reorganization of actin filaments is also involved in Ca2+-dependent exocytosis. Therefore, rabphilin-3A may serve as a linker for Rab3A and cytoskeleton...
  89. pmc Rho1p-Bni1p-Spa2p interactions: implication in localization of Bni1p at the bud site and regulation of the actin cytoskeleton in Saccharomyces cerevisiae
    T Fujiwara
    Department of Molecular Biology and Biochemistry, Osaka University Medical School, Suita 565 0871, Japan
    Mol Biol Cell 9:1221-33. 1998
    ..These results indicate that both Rho1p and Spa2p are involved in the localization of Bni1p at the growth sites where Rho1p regulates reorganization of the actin cytoskeleton through Bni1p...
  90. ncbi Rab11a is modified in vivo by isoprenoid geranylgeranyl
    P Gromov
    Department of Medical Biochemistry and Danish Centre for Human Genome Research, Aarhus University
    Electrophoresis 19:1803-7. 1998
    ..The data implied that in vivo there must exist other determinant(s) that are necessary for prenyltransferase recognition...
  91. ncbi Rho-kinase as a novel therapeutic target in treatment of cardiovascular diseases
    Hiroaki Shimokawa
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    J Cardiovasc Pharmacol 39:319-27. 2002
    ..It is possible that Rho-kinase is also involved in the pathogenesis of other forms of cardiovascular diseases. Thus, Rho-kinase could be regarded as a novel therapeutic target in treatment of cardiovascular diseases...
  92. ncbi Involvement of Rho-kinase pathway for angiotensin II-induced plasminogen activator inhibitor-1 gene expression and cardiovascular remodeling in hypertensive rats
    Naohiko Kobayashi
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    J Pharmacol Exp Ther 301:459-66. 2002
    ..Thus, inhibition of the Rho-kinase pathway may be at least a useful therapeutic strategy for treating cardiovascular remodeling...
  93. ncbi Integrins regulate Rac targeting by internalization of membrane domains
    Miguel A Del Pozo
    Department of Cell Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 303:839-42. 2004
    ..Regulation of lipid rafts by integrin signals may regulate the location of membrane domains such as lipid rafts and thereby control domain-specific signaling events in anchorage-dependent cells...
  94. ncbi ARF6 GTPase controls bacterial invasion by actin remodelling
    María Eugenia Balañá
    Unite de Biologie des Interactions Cellulaires, Institut Pasteur, CNRS URA 2582, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
    J Cell Sci 118:2201-10. 2005
    ..These results indicate that ARF6, which controls membrane delivery during phagocytosis of red blood cells in macrophages, has a different role in the entry of this small bacterium, controlling cytoskeletal reorganization...
  95. ncbi Rap2, but not Rap1 GTPase is expressed in human red blood cells and is involved in vesiculation
    Fabio Greco
    Department of Biochemistry, University of Pavia, via Bassi 21, 27100 Pavia, Italy
    Biochim Biophys Acta 1763:330-5. 2006
    ..RT-PCR analysis of mRNA extracted from highly purified reticulocytes confirmed the expression of Rap2b, but not Rap2a, Rap2c, Rap1a or Rap1b...
  96. ncbi Pharmacological evidence for activation of phospholipid and small GTP binding protein signalling cascades by Nod factors
    M N Kelly-Skupek
    Department of Pharmaceutical Biology, Monash University, 381 Royal Parade, Parkville VIC 3052, Australia
    Plant Physiol Biochem 44:132-42. 2006
    ..Root hair deformation is an important early stage in the formation of nitrogen fixing nodules and this study highlights that these processes may depend on signalling cascades involving phospholipids and small GTP binding proteins...
  97. pmc ARF6-regulated shedding of tumor cell-derived plasma membrane microvesicles
    Vandhana Muralidharan-Chari
    Department of Biological Sciences, University of Notre Dame, IN 46556, USA
    Curr Biol 19:1875-85. 2009
    ..Several studies have implicated the small GTP-binding protein ARF6 in tumor cell invasion, although the molecular basis by which ARF6 facilitates this process is unclear...
  98. doi Metastasis: wherefore arf thou?
    Richard T Premont
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Curr Biol 19:R1036-8. 2009
    ..A recent study identifies yet another role for Arf6 in metastasis - as a regulator of plasma-membrane-derived microvesicle release...
  99. doi Induction of small G protein RhoB by non-genotoxic stress inhibits apoptosis and activates NF-κB
    Yi Dong Li
    Department of Pathophysiology, Second Military Medical University, and Department of Burn Surgery, Changhai Hospital, Shanghai, People s Republic of China
    J Cell Physiol 226:729-38. 2011
    It has been reported by us and other groups that the expression of small GTP binding protein RhoB can be induced by genotoxic stressors and glucocorticoid (GC), a stress hormone that plays a key role in stress response...
  100. doi Inactivation of Cdc42 in neural crest cells causes craniofacial and cardiovascular morphogenesis defects
    Yang Liu
    Department of Medical Physiology, College of Medicine, Texas A and M University Health Science Center, Temple, TX 76504, USA
    Dev Biol 383:239-52. 2013
    ..In summary, our results demonstrate that Cdc42 plays an essential role in NCC migration, and inactivation of Cdc42 in NCCs impairs craniofacial and cardiovascular development in mice. ..
  101. doi Rap2B GTPase: structure, functions, and regulation
    Zhesi Zhu
    Cancer Institute, Xuzhou Medical College, Xuzhou, 221002, Jiangsu, People s Republic of China
    Tumour Biol 37:7085-93. 2016
    b>Rap2B GTPase, a member of Ras-related protein superfamily, was first discovered from a platelet cDNA library in the early 1990s...

Research Grants41

  1. INTESTINE IN CHRONIC PORTAL HYPERTENSION
    JOSEPH BENOIT; Fiscal Year: 2004
    ..Second, failure of the small GTP binding protein Rho A to activate in response to GI and Gq coupled vasoconstrictor is suggested, as this event would ..
  2. Regulation of Neuronal Survival by the Rit GTPase
    DOUGLAS ALLEN ANDRES; Fiscal Year: 2012
    ..Thus, the goal of this research is to speed progress toward therapeutic exploitation of this protein in neurodegenerative disease. ..
  3. JAMES RICHARD GOLDENRING; Fiscal Year: 2016
    ..In intestinal cells, we also have demonstrated that loss of Rab25, an epithelial-specific small GTP binding protein, in Rab25 KO mice promotes intestinal and colonic neoplasia and knockdown of Rab25 expression in CaCo-2 ..
  4. Inorganic phosphate regulated proliferation, transformation and tumorigenesis
    George R Beck; Fiscal Year: 2013
    ..test the hypothesis that phosphate transport in combination with FGF receptor activation regulates the small GTP binding protein, N-ras and subsequent AP-1 transcriptional activation necessary for the phosphate-induced proliferation ..
  5. The Role of FKBP38 in tumorigenesis associated with Tsc deficiency
    Yu Jiang; Fiscal Year: 2012
    ..of TSC1 and TSC2, hamartin and tuberin, form a complex that negatively regulates Rheb, a Ras-like small GTP binding protein. It has been recently found that mTOR, the target of rapamycin, is a major effector of Rheb...
  6. MARIA IRENE KONTARIDIS; Fiscal Year: 2014
    ..RhoA is a small GTP binding protein involved in important cellular functions including cell proliferation, migration and cytoskeletal ..
  7. Ras and Phosphoinositide 3-kinase Signaling in Lens Development
    Lixing W Reneker; Fiscal Year: 2012
    ..This knowledge will help to develop new methods to prevent and treat posterior capsular opacification (PCO), the most common complication of cataract surgery. ..
  8. Sympathetic Control in Heart Failure: A Role of Statins
    Irving H Zucker; Fiscal Year: 2010
    ..The role of the small GTP binding protein Rho and Rho Kinase and NO synthase will be investigated in intact animals and in isolated neuronal cell ..
  9. Chung Owyang; Fiscal Year: 2016
    ..will be complemented by Western blot and RT-PCR studies to demonstrate HFD results in upregulation of the Epac-Rap2B-PLCe and TRESK pathways in a time course study...
  10. Novel Insulin Signals Regulating GLUT4 Translocation
    Jeffrey Pessin; Fiscal Year: 2005
    ..Recently, we have determined that a novel small GTP binding protein in the Rho family (TC1O) provides essential function for the insulin-stimulated translocation of GLUT4 ..
  11. RACE PATHWAY IN THE REGULATION OF CYTOKINESIS
    Denis Larochelle; Fiscal Year: 1999
    ..The identification of the proteins required for cytokinesis, and how they interact with one another, will greatly increase our understanding of how this process is regulated in cells. ..
  12. SMOOTH MUSCLE MIGRATION AFTER VASCULAR RECONSTRUCTION
    K Kent; Fiscal Year: 2000
    ....
  13. Attenuation of mucous cell metaplasia by Rad
    Mary Chang; Fiscal Year: 2006
    ..profile study of retinoic acid-induced airway epithelial cell differentiation, we have discovered that a small GTP binding protein, Rad, plays an important role in the attenuation of mucin gene expression mad secretion...
  14. cAMP modulation of bile induced hepatocyte apoptosis
    CYNTHIA LEVEILLE WEBSTER; Fiscal Year: 2009
    ..involving activation of cAMP dependent guanine exchange: factor (cAMP-GEF) which signals through the small GTP binding protein Rap...
  15. Mechanism of vascular alpha2C-adrenoceptor mobilization
    Maqsood Chotani; Fiscal Year: 2009
    ..The role of this signaling pathway in phosphorylating the conserved filamin-2 serine2113 will be examined, and the potential relevance to receptor mobilization at 370C and 280C. ..
  16. CONTROL OF SIGMA B ACTIVITY IN B SUBTILIS
    William Haldenwang; Fiscal Year: 2005
    ..that activates sigma B is unknown; however, recent evidence implicates the bacterium's ribosome and a small GTP binding protein (Obg) in this process...
  17. SIGNALS FOR RPE SURVIVAL IN VITRO
    DENNIS DEFOE; Fiscal Year: 1999
    ..By defining specific molecules as targets for promoting or inhibiting cell survival or death, information gained from these studies may form the basis for designing therapeutic strategies to intervene in RPE proliferation and atrophy. ..
  18. SPATIAL CONTROL OF CELL POLARITY DURING YEAST BUDDING
    Hay Oak Park; Fiscal Year: 2003
    ..These include the Ras-like small GTP binding protein Bud1, the GTPase Activating Protein (GAP) Bud2, and the Guanine nucleotide Exchange Factor (GEF) Bud5...
  19. Corneal Innervation and Epithelial Cell Migration
    JES KLARLUND; Fiscal Year: 2007
    ..GRP1 is an activator for the small GTP binding protein ARF6, which has been shown to regulate extension of lamellipodia and cell movement...
  20. INTEGRINS AND D3 PHOSPHOINOSITIDES IN CANCER
    Leslie Shaw; Fiscal Year: 2000
    ..The goal is to identify molecular targets for future metastasis related study. ..
  21. Regulation of actin by Rac and Phosphoinositides
    Christopher Carpenter; Fiscal Year: 2005
    ..We should understand better how cells move and advance the fields of cell biology and signal transduction. ..
  22. MOLECULAR ANALYSIS OF EAR DEVELOPMENT
    MARGARET LOMAX; Fiscal Year: 2000
    ..The results of these studies should provide insight into the molecular processes involved in ear development, and determine whether these processes are reactivated during hair cell regeneration. ..
  23. RAB5 AND APP PROCESSING AS RELATED TO AGING
    Joseph Buxbaum; Fiscal Year: 2002
    ....
  24. Fyn and Rap1 in T cell Activation and Immune Response
    Konstantina Alexandropoulos; Fiscal Year: 2004
    ..4) We will examine the CD4+ helper and CD8+ cytotoxic T cell responses in SindeltaC transgenic mice and test whether SindeltaC-mediated activation of Fyn and Rapl correlates with T cell anergy in vivo. ..
  25. High throughput assay for small G protein activation
    JACQUES WEISSMAN; Fiscal Year: 2005
    The small GTP binding protein superfamily (consisting of small, monomeric GTP hydrolyzing proteins or GTPases) regulates diverse cellular processes including gene expression, cellular proliferation, cytoskeletal reorganization, vesicle ..
  26. CROSSTALK BETWEEN CAMP AND RAS IN TSH GROWTH SIGNALING
    Judy Meinkoth; Fiscal Year: 2004
    ..Given the high frequency (ca 100 percent) of thyroid tumors observed at autopsy, identification of growth regulatory circuits targeted by cAMP is an important and exciting area for future investigation. ..
  27. Regulation of Superoxide Production by the Macula Densa during TGF
    Ruisheng Liu; Fiscal Year: 2010
    ..We believe the results of the present study will help us better understand the causes of hypertension and might reveal new approaches for treatment. ..
  28. SIGNALING PATHWAYS OF ARF GTPASES AND ARF GAPS
    Richard Premont; Fiscal Year: 2005
    ..abstract_text> ..
  29. WNT PROTEINS IN ADULT, AGED AND OSTEOARTHRITIC CARTILAGE
    Karen Yates; Fiscal Year: 2005
    ..This work will also provide a solid foundation for future research on Wnts in cartilage biology. ..
  30. PHOSPHOLIPASE C AND ISLET BETA CELLS
    GRANT KELLEY; Fiscal Year: 2002
    ..This novel signaling pathway may play a critical role in glucose and hormone stimulated insulin secretion and beta cell function. ..
  31. Activation of eNOS by Steroid Hormones
    James Liao; Fiscal Year: 2006
    ....
  32. RAP1A AND RAP1B IN THE DIAGNOSIS AND TMT - ORAL CANCER
    NISHA D SILVA; Fiscal Year: 2004
    ..The third segment involves the design of a protocol to investigate the use of rap1A in gene therapy to treat residual epithelial dysplasia or squamous cell carcinoma lesions. ..
  33. Role of Prostaglandins & Phospholipase A in melanocytes
    Glynis Scott; Fiscal Year: 2009
    ..We hypothesize that PG and phospholipases stimulate HM dendricity, MS transfer &pigmentation through different mechanisms that act synergistically to modulate cutaneous pigmentation following UVR. ..
  34. MENTORED ORIENTED RESEARCH CAREER DEVELOPMENT AWARD
    Jared Gollob; Fiscal Year: 2004
    ....
  35. TRANSCRIPTIONAL REGULATORS OF CHONDROINDUCTION BY DBP
    Karen Yates; Fiscal Year: 2004
    ..We will determine which DBP-regulated transcription factors are necessary and/or sufficient for postnatal chondrogenesis. This proposed work would have a high impact of design of strategies for repair and/or regeneration of cartilage. ..
  36. Endothelial Akt in Vascular Injury
    James Liao; Fiscal Year: 2009
    ..Three specific aims are proposed, which will study the role of endothelial Akt in models of vascular injury and atherosclerosis. ..
  37. Role of PI3-Kinase in Estrogen-induced eNOS Activation
    James Liao; Fiscal Year: 2007
    ..These results may explain some of the actions of selective estrogen receptor modulators (SERMs) and provide a therapeutic basis for using estrogens in cardiovascular disease. ..
  38. A Universal Mouse Line to Assess Tumor Clonality
    Daniel Altschuler; Fiscal Year: 2006
    ..Therefore, we consider this line will be of interest to other NIH institutes (e.g. NIDDK, NIEHS, NCI) and that will contribute significantly to many areas of research. ..
  39. Toll-Like Receptors in Bacterial Antigen Induced HIV-LTR
    Ozlem Equils; Fiscal Year: 2004
    ..abstract_text> ..
  40. Dopamine Receptor Regulation by GRKs in Drug Abuse
    Richard Premont; Fiscal Year: 2008
    ..The results of these studies will define the role of GRK6 in setting the basal tone of dopamine signaling in the striatum. [unreadable] [unreadable] [unreadable]..
  41. Rap 1-Mediated Protein Transport in Oral Cancer
    NISHA D SILVA; Fiscal Year: 2006
    ..The significance of this research is that it explores an important and novel mechanism for nucleocytoplasmic transport of pro-proliferative proteins in oral cancer, thereby identifying novel treatment targets. [unreadable] [unreadable]..