RAP2A

Summary

Gene Symbol: RAP2A
Description: RAP2A, member of RAS oncogene family
Alias: K-REV, KREV, RAP2, RbBP-30, ras-related protein Rap-2a, RAP2, member of RAS oncogene family (K-rev)
Species: human

Top Publications

  1. ncbi Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs
    J de Rooij
    Department of Physiological Chemistry and Centre for Biomedical Genetics, University Medical Centre Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    J Biol Chem 275:20829-36. 2000
  2. ncbi Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase
    Noriko Machida
    Division of Cell Biology, Graduate School of Medicine, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara cho, Okinawa 903 0215, Japan
    J Biol Chem 279:15711-4. 2004
  3. ncbi The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton
    Kiyohito Taira
    Division of Cell Biology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara cho, Okinawa 903 0215, Japan
    J Biol Chem 279:49488-96. 2004
  4. pmc Constitutively active Rap2 transgenic mice display fewer dendritic spines, reduced extracellular signal-regulated kinase signaling, enhanced long-term depression, and impaired spatial learning and fear extinction
    Jubin Ryu
    The Picower Institute for Learning and Memory, RIKEN Massachusetts Institute of Technology Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Neurosci 28:8178-88. 2008
  5. ncbi Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region
    V Pizon
    INSERM U 248, Faculte de Medecine Lariboisiere Saint Louis, Paris, France
    Oncogene 3:201-4. 1988
  6. ncbi Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2
    H Bea Kuiperij
    Department of Physiological Chemistry and Centre for Biomedical Genetics, University Medical Centre Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Biochim Biophys Acta 1593:141-9. 2003
  7. doi MINK is a Rap2 effector for phosphorylation of the postsynaptic scaffold protein TANC1
    Hideo Nonaka
    Division of Cell Biology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara cho, Okinawa 903 0215, Japan
    Biochem Biophys Res Commun 377:573-8. 2008
  8. doi RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP-binding proteins and mediate Rap2-specific nucleotide exchange
    Elif Yaman
    Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey
    FEBS J 276:4607-16. 2009
  9. pmc The COOH-terminal domain of the Rap1A (Krev-1) protein is isoprenylated and supports transformation by an H-Ras:Rap1A chimeric protein
    J E Buss
    La Jolla Cancer Research Foundation, California 92037
    Mol Cell Biol 11:1523-30. 1991
  10. pmc Human leukocyte antigen class II alleles influence levels of antibodies to the Plasmodium falciparum asexual-stage apical membrane antigen 1 but not to merozoite surface antigen 2 and merozoite surface protein 1
    Armead H Johnson
    Departments of Pediatrics, Georgetown University, Washington, DC 20057, USA
    Infect Immun 72:2762-71. 2004

Research Grants

  1. John R Hepler; Fiscal Year: 2016
  2. Investigating the Role of Malaria Rhoptry-Associated Protein 2 in Severe Anemia
    NOE DAVID GOMEZ; Fiscal Year: 2010
  3. RGS proteins as novel integrators of G protein and MAPK signaling
    JOHN HEPLER; Fiscal Year: 2009
  4. Role of Programmed Cell Death10 (PDCD10) in p38 MAP kinase activation and PDK1 si
    Sompop Bencharit; Fiscal Year: 2010
  5. Rytis Prekeris; Fiscal Year: 2016
  6. David A Calderwood; Fiscal Year: 2016
  7. Exploring RGS14 signaling functions in the CA2 hippocampus
    John R Hepler; Fiscal Year: 2012
  8. Mechanisms of Synaptic Depression: Focus on Rap Signaling Pathways
    J Julius Zhu; Fiscal Year: 2010
  9. PATHOLOGY IN ANTICANCER/CANCER SUPPRESSOR REGULATION
    Robert Scott; Fiscal Year: 1993
  10. PHOSPHOLIPASE C AND ISLET BETA CELLS
    GRANT KELLEY; Fiscal Year: 2002

Patents

  1. NOVEL PROTEINS, DNA CODING FOR SAID PROTEINS, AND THEIR USE

Scientific Experts

Detail Information

Publications186 found, 100 shown here

  1. ncbi Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs
    J de Rooij
    Department of Physiological Chemistry and Centre for Biomedical Genetics, University Medical Centre Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    J Biol Chem 275:20829-36. 2000
    ..Here we show that both GEFs efficiently activate Rap2 as well...
  2. ncbi Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase
    Noriko Machida
    Division of Cell Biology, Graduate School of Medicine, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara cho, Okinawa 903 0215, Japan
    J Biol Chem 279:15711-4. 2004
    Little is known about the specific signaling roles of Rap2, a Ras family small GTP-binding protein...
  3. ncbi The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton
    Kiyohito Taira
    Division of Cell Biology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara cho, Okinawa 903 0215, Japan
    J Biol Chem 279:49488-96. 2004
    b>Rap2 belongs to the Ras family of small GTP-binding proteins, but its specific roles in cell signaling remain unknown...
  4. pmc Constitutively active Rap2 transgenic mice display fewer dendritic spines, reduced extracellular signal-regulated kinase signaling, enhanced long-term depression, and impaired spatial learning and fear extinction
    Jubin Ryu
    The Picower Institute for Learning and Memory, RIKEN Massachusetts Institute of Technology Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Neurosci 28:8178-88. 2008
    Within the Ras superfamily of GTPases, Rap1 and Rap2 are the closest homologs to Ras. In non-neural cells, Rap signaling can antagonize Ras signaling. In neurons, Rap also seems to oppose Ras in terms of synaptic function...
  5. ncbi Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region
    V Pizon
    INSERM U 248, Faculte de Medecine Lariboisiere Saint Louis, Paris, France
    Oncogene 3:201-4. 1988
    We have characterized two new ras-related genes rap1 and rap2 from a human cDNA library, by hybridization with the Drosophila Dras3 gene at low stringency conditions...
  6. ncbi Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2
    H Bea Kuiperij
    Department of Physiological Chemistry and Centre for Biomedical Genetics, University Medical Centre Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Biochim Biophys Acta 1593:141-9. 2003
    ..PDZ-GEF1 efficiently exchanges nucleotides of both Rap1 and Rap2, but has also been implicated in mediating cAMP-induced Ras activation through binding of cAMP to the RCBD...
  7. doi MINK is a Rap2 effector for phosphorylation of the postsynaptic scaffold protein TANC1
    Hideo Nonaka
    Division of Cell Biology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara cho, Okinawa 903 0215, Japan
    Biochem Biophys Res Commun 377:573-8. 2008
    Rap1 and Rap2 are similar Ras-like G proteins but perform distinct functions...
  8. doi RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP-binding proteins and mediate Rap2-specific nucleotide exchange
    Elif Yaman
    Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey
    FEBS J 276:4607-16. 2009
    ..as Ras family proteins, we established that RasGEF1A and RasGEF1B function as very specific exchange factors for Rap2, a member of the Rap subfamily of Ras-like G-proteins...
  9. pmc The COOH-terminal domain of the Rap1A (Krev-1) protein is isoprenylated and supports transformation by an H-Ras:Rap1A chimeric protein
    J E Buss
    La Jolla Cancer Research Foundation, California 92037
    Mol Cell Biol 11:1523-30. 1991
    ..This demonstrates that the modifications and localization signals of the COOH terminus of Rap1A can support the interactions between H-Ras and membranes that are required for transformation...
  10. pmc Human leukocyte antigen class II alleles influence levels of antibodies to the Plasmodium falciparum asexual-stage apical membrane antigen 1 but not to merozoite surface antigen 2 and merozoite surface protein 1
    Armead H Johnson
    Departments of Pediatrics, Georgetown University, Washington, DC 20057, USA
    Infect Immun 72:2762-71. 2004
    ..association between HLA class II alleles and levels of antibodies to rhoptry-associated protein 1 (RAP1) and RAP2, indicates that HLA influences the levels of antibodies to three of the five vaccine candidate antigens that we ..
  11. doi M-Ras evolved independently of R-Ras and its neural function is conserved between mammalian and ascidian, which lacks classical Ras
    Etsuko Keduka
    Department of Biology, Graduate School of Science, Chiba University, 1 33 Yayoicho, Inageku, Chiba, Chiba 263 8522, Japan
    Gene 429:49-58. 2009
    ..By contrast, both the ascidians contain single genes orthologous to Mras, Rras, Ral, Rap1, and Rap2. A single Mras orthologue exists from nematode to mammalian...
  12. ncbi Small GTP-binding protein Ral is involved in cAMP-mediated release of von Willebrand factor from endothelial cells
    Mariska G Rondaij
    Department of Plasma Proteins, Sanquin Research at CLB, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 24:1315-20. 2004
    ..In the present study, we investigated whether Ral is also involved in cAMP-mediated vWF release...
  13. pmc Phosphorylated guanine nucleotide exchange factor C3G, induced by pervanadate and Src family kinases localizes to the Golgi and subcortical actin cytoskeleton
    Vegesna Radha
    Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007 India
    BMC Cell Biol 5:31. 2004
    ..It activates Rap1, Rap2 and R-Ras members of the Ras family of GTPases...
  14. ncbi Isolation and characterization of the krev-1 gene, a novel member of ras superfamily in Neurospora crassa: involvement in sexual cycle progression
    S Ito
    Dept of Regulation Biology, Faculty of Science, Saitama University, Urawa, Japan
    Mol Gen Genet 255:429-37. 1997
    ..a novel member of the ras superfamily from the filamentous fungus Neurospora crassa and obtained a mammalian Krev-1 homolog. We named the gene krev-1 and analyzed its structure and function...
  15. pmc MINK and TNIK differentially act on Rap2-mediated signal transduction to regulate neuronal structure and AMPA receptor function
    Natasha K Hussain
    Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Neurosci 30:14786-94. 2010
    ..MINK) and closely related TRAF2/Nck-interacting kinase (TNIK) are proteins that specifically bind to activated Rap2 and are thus hypothesized to relay its downstream signal transduction...
  16. pmc Arabidopsis transcriptome profiling indicates that multiple regulatory pathways are activated during cold acclimation in addition to the CBF cold response pathway
    Sarah Fowler
    Department of Energy Plant Research Laboratory and Department of Crop and Soil Sciences, Michigan State University, East Lansing, MI 48824 1312, USA
    Plant Cell 14:1675-90. 2002
    ..Of the cold-responsive genes, 48 encode known or putative transcription factors. Two of these, RAP2.1 and RAP2.6, were activated by CBF expression and thus presumably control subregulons of the CBF regulon...
  17. doi Localisation and timing of expression of putative Plasmodium berghei rhoptry proteins in merozoites and sporozoites
    Marta Tufet-Bayona
    The Malaria Centre, and the Division of Cell and Molecular Biology, Imperial College London, London, UK
    Mol Biochem Parasitol 166:22-31. 2009
    ..or C-MYC) were used to analyse the expression and cellular localisation of a known Plasmodium rhoptry protein (RAP2/3) and putative homologues of two Toxoplasma rhoptry proteins (rhoptry neck protein 2, RON2 and putative rhoptry ..
  18. ncbi Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction
    J F Rebhun
    Department of Biochemistry and Molecular Biology and Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 275:34901-8. 2000
    ..MR-GEF (M-Ras-regulated GEF, KIAA0277) and PDZ-GEF (KIAA0313) bound specifically to nucleotide-free Rap1 and Rap1/Rap2, respectively. Both proteins functioned as Rap1 GEFs in vivo...
  19. ncbi The RAP1 guanine nucleotide exchange factor Epac2 couples cyclic AMP and Ras signals at the plasma membrane
    Yu Li
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, and Walther Cancer Institute, Indianapolis, Indiana 46202, USA
    J Biol Chem 281:2506-14. 2006
    ..Therefore, despite its previous description as a Ras antagonist or independently functioning GTPase, Rap1/Krev-1 may additionally act downstream of Ras in cells that express the cyclic AMP-regulated GEF, Epac2.
  20. ncbi Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. Segregate expression profiles from a rap1GAP gene product
    H Kurachi
    Department of Immunology and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto 606, Japan
    J Biol Chem 272:28081-8. 1997
    ..Baculovirally expressed p130(SPA-1) exhibited GTPase-activating protein (GAP) activity for Rap1 and Rap2, but not for Ras, Rho, Cdc42, Rac, and Ran, with comparable specific activity to the rap1GAP gene product (p85/95(..
  21. ncbi Activation of the Rap GTPases in B lymphocytes modulates B cell antigen receptor-induced activation of Akt but has no effect on MAPK activation
    Sherri L Christian
    Department of Microbiology and Immunology, University of British Columbia, 6174 University Boulevard, Vancouver, BC V6T 1Z3, Canada
    J Biol Chem 278:41756-67. 2003
    Signaling by the B cell antigen receptor (BCR) activates the Rap1 and Rap2 GTPases, putative antagonists of Ras-mediated signaling...
  22. ncbi The molecular heterogeneity of the smg-21/Krev-1/rap1 proteins, a GTP-binding protein having the same effector domain as ras p21s, in bovine aortic smooth muscle membranes
    M Kawata
    Department of Internal Medicine 1st Division, Kobe University School of Medicine, Japan
    Oncogene 6:841-8. 1991
    ..These results indicate that smg p21A and -B coexist in bovine aortic smooth muscle membranes and suggest that smg p21A and -B may serve as intermediates for cyclic AMP actions...
  23. pmc PEA3 sites within the progression elevated gene-3 (PEG-3) promoter and mitogen-activated protein kinase contribute to differential PEG-3 expression in Ha-ras and v-raf oncogene transformed rat embryo cells
    Z Su
    Department of Urology, Department of Pathology and Department of Neurosurgery, Herbert Irving Comprehensive Cancer Center, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Nucleic Acids Res 29:1661-71. 2001
    ..analysis was also performed using CREF cells doubly transformed with Ha-ras and the Ha-ras specific suppressor gene Krev-1, which inhibits the transformed phenotype in vitro...
  24. ncbi Ras and relatives--job sharing and networking keep an old family together
    Annette Ehrhardt
    The Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
    Exp Hematol 30:1089-106. 2002
    ..proteins, the Ras subfamily of the Ras superfamily includes R-Ras, TC21 (R-Ras2), M-Ras (R-Ras3), Rap1A, Rap1B, Rap2A, Rap2B, RalA, and RalB...
  25. ncbi KRIT1/cerebral cavernous malformation 1 protein localizes to vascular endothelium, astrocytes, and pyramidal cells of the adult human cerebral cortex
    Ozlem Guzeloglu-Kayisli
    Neurovascular Surgery Program, Department of Neurosurgery, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Neurosurgery 54:943-9; discussion 949. 2004
    ..Although recent studies have suggested that Krev-1 interaction trapped 1 (KRIT1) is a microtubule-associated protein that interacts with integrin cytoplasmic domain-..
  26. doi Magnaporthe grisea avirulence gene ACE1 belongs to an infection-specific gene cluster involved in secondary metabolism
    Jerome Collemare
    UMR5240 CNRS UCB INSA BAYER CropScience, 14 20 rue Pierre Baizet, 69263 Lyon Cedex 09, France
    New Phytol 179:196-208. 2008
    ..in secondary metabolism as they encode enzymes such as a second PKS-NRPS (SYN2), two enoyl reductases (RAP1 and RAP2) and a putative Zn(II)(2)Cys(6) transcription factor (BC2)...
  27. ncbi Mutations in the gene encoding KRIT1, a Krev-1/rap1a binding protein, cause cerebral cavernous malformations (CCM1)
    T Sahoo
    Department of Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Hum Mol Genet 8:2325-33. 1999
    ..sequence-based positional cloning strategy, we have identified KRIT1, encoding a protein that interacts with the Krev-1/rap1a tumor suppressor, as the CCM1 gene...
  28. ncbi Transcription status of vaccine candidate genes of Plasmodium falciparum during the hepatic phase of its life cycle
    Myriam Bodescot
    INSERM U511, Immunobiologie Cellulaire et Moleculaire des Infections Parasitaires, Centre Hospitalier Universitaire Pitie Salpetriere, Universite Pierre et Marie Curie, 91 Boulevard de l Hopital, 75643 Paris Cedex 13, France
    Parasitol Res 92:449-52. 2004
    The CSP, EMP2/MESA, MSP2, MSP3, MSP5, RAP1, RAP2, RESA1, SERA1 and SSP2/TRAP genes of Plasmodium falciparum are vaccine candidates...
  29. pmc Effects of Wei Chang An on expression of multiple genes in human gastric cancer grafted onto nude mice
    Ai Guang Zhao
    Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 Wanping Road, Shanghai 200032, China
    World J Gastroenterol 14:693-700. 2008
    ..To investigate the expression of multiple genes in Chinese jianpi herbal recipe Wei Chang An (WCA) in human gastric cancer cell line SGC-7901...
  30. doi Role of Arabidopsis RAP2.4 in regulating light- and ethylene-mediated developmental processes and drought stress tolerance
    Rong Cheng Lin
    Boyce Thompson Institute for Plant Research, Cornell University, Ithaca, NY 14853, USA
    Mol Plant 1:42-57. 2008
    ..Here, we report functional characterization of an AP2/DREB-type transcription factor, Arabidopsis RAP2.4, in mediating light and ethylene signaling. Expression of the RAP2...
  31. pmc Farnesylation or geranylgeranylation? Efficient assays for testing protein prenylation in vitro and in vivo
    Wolfgang Benetka
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    BMC Biochem 7:6. 2006
    ....
  32. ncbi Identification of novel genes expressed in hypoxic brain condition by fluorescence differential display
    Kazuya Ikematsu
    Division of Forensic Pathology and Science, Department of Translational Medical Sciences, Course of Medical and Dental Sciences, Graduate School of Biochemical Sciences, Nagasaki University, Nagasaki, Japan
    Forensic Sci Int 169:168-72. 2007
    ..In Group A25-30, only RAP2 interacting protein and another novel cDNA were induced. In Group A25-0, one novel gene was detected...
  33. doi Role of the cAMP-binding protein Epac in cardiovascular physiology and pathophysiology
    Mélanie Métrich
    INSERM, UMR S 769, Signalisation et Physiopathologie Cardiaque, Châtenay Malabry 92296, France
    Pflugers Arch 459:535-46. 2010
    ..family, including Epac1 and Epac2, are guanine nucleotide exchange factors for the Ras-like small GTPases Rap1 and Rap2 and function independently of protein kinase A...
  34. pmc Transcriptional regulatory network triggered by oxidative signals configures the early response mechanisms of japonica rice to chilling stress
    Kil Young Yun
    School of Biology and Ecology, University of Maine, Orono, ME 04469, USA
    BMC Plant Biol 10:16. 2010
    ..The components, hierarchical organization and physiological consequences of this network were further dissected by a systems-level approach...
  35. ncbi Chemical reverse transformation of CHO-K1 cells induces changes in expression of a candidate tumour suppressor and of a gene not previously characterised as transformation related
    C Z Bachrati
    Institute of Genetics, Biological Research Centre of Hungarian Academy of Sciences, Szeged
    Eur J Cell Biol 78:561-6. 1999
    ..The third has homology, with transcriptional or processing variations, to a human genomic sequence, a positional candidate for a tumour suppressor gene, encoding the Krit1 protein which interacts with the Ras-family GTPase Krev-1.
  36. ncbi Improving the production of the denatured recombinant N-terminal domain of rhoptry-associated protein 2 from a Plasmodium falciparum target in the pathology of anemia in falciparum malaria
    Luis Andre Mariuba
    Instituto Leônidas e Maria Deane Fiocruz, Rua Teresina 476, 69057 070 Manaus, AM, Brasil
    Mem Inst Oswaldo Cruz 103:522-7. 2008
    Rhoptry-associated protein 2 (RAP2) is known to be discharged from rhoptry onto the membrane surface of infected and uninfected erythrocytes (UEs) ex vivo and in vitro and this information provides new insights into the understanding of ..
  37. doi The Arabidopsis AP2/ERF transcription factor RAP2.6 participates in ABA, salt and osmotic stress responses
    Qiang Zhu
    Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, 300 Fenglin Road, Shanghai 200032, China
    Gene 457:1-12. 2010
    AP2/ERF proteins play crucial roles in various biological processes. RAP2.6, an Arabidopsis AP2/ERF family member, has been reported to function in plant response to biotic stress, but whether it also functions in plant response to ..
  38. pmc Tissue and subcellular distributions of the smg-21/rap1/Krev-1 proteins which are partly distinct from those of c-ras p21s
    S Kim
    Department of Biochemistry, Kobe University School of Medicine, Japan
    Mol Cell Biol 10:2645-52. 1990
    We have made a specific antiserum recognizing both smg p21A (the rap1A/Krev-1 protein) and -B (the rap1B protein), ras p21-like GTP-binding proteins having the same putative effector domain as ras p21s and have used this antiserum to ..
  39. ncbi Expression patterns of novel genes during mouse preimplantation embryogenesis
    G L Temeles
    Department of Biology, University of Pennsylvania, Philadelphia 19104 6018
    Mol Reprod Dev 37:121-9. 1994
    ..One cDNA was 90% homologous to the ras-related gene Krev/rap 1A...
  40. ncbi Interaction of the low-molecular-weight GTP-binding protein rap2 with the platelet cytoskeleton is mediated by direct binding to the actin filaments
    M Torti
    Department of Biochemistry, University of Pavia, 27100 Pavia, Italy
    J Cell Biochem 75:675-85. 1999
    The interaction of the low-molecular-weight GTP-binding protein rap2 with the cytoskeleton from thrombin-aggregated platelets was investigated by inducing depolymerization of the actin filaments, followed by in vitro-promoted ..
  41. ncbi Stimulation of phospholipase C-epsilon by the M3 muscarinic acetylcholine receptor mediated by cyclic AMP and the GTPase Rap2B
    Sandrine Evellin
    Institut fur Pharmakologie, Universitatsklinikum Essen, D 45122 Essen, Germany
    J Biol Chem 277:16805-13. 2002
    ..were mimicked by expression of inactive Rap2B, but not of other inactive GTPases (Rac1, Ras, RalA, Rap1A, and Rap2A)...
  42. ncbi The Rap GTPases regulate B cell migration toward the chemokine stromal cell-derived factor-1 (CXCL12): potential role for Rap2 in promoting B cell migration
    Sarah J McLeod
    Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada
    J Immunol 169:1365-71. 2002
    ..We found that treating B cells with SDF-1 resulted in the rapid activation of both Rap1 and Rap2. Moreover, blocking the activation of Rap1 and Rap2 via the expression of a Rap-specific GTPase-activating protein ..
  43. pmc The high-risk human papillomavirus type 16 E6 counters the GAP function of E6TP1 toward small Rap G proteins
    Latika Singh
    Division of Radiation and Cancer Biology, Department of Radiation Oncology, New England Medical Center, Boston, Massachusetts 02111, USA
    J Virol 77:1614-20. 2003
    ..Using two different approaches, we now demonstrate that human E6TP1 exhibits GAP activity for Rap1 and Rap2, confirming recent findings that a closely related rat homologue exhibits Rap-specific GAP activity...
  44. ncbi Identification of a novel KRIT1 mutation in an Italian family with cerebral cavernous malformation by the protein truncation test
    Valeria Marini
    Department of Oncology, Biology and Genetics, University of Genova, Viale Benedetto XV, 6, Genoa 16132, Italy
    J Neurol Sci 212:75-8. 2003
    ..Three CCM loci have been mapped, but the gene for only one locus--KRIT1 coding for Krev-1/rap1 interaction trapped 1 (KRIT1) protein, which is responsible for more than 40% of familial cases--has been ..
  45. ncbi Activation of a COI1-dependent pathway in Arabidopsis by Pseudomonas syringae type III effectors and coronatine
    Ping He
    Department of Plant Pathology, Kansas State University, Manhattan, KS 66506, USA
    Plant J 37:589-602. 2004
    ..Pseudomonas syringae strains activate the transcription of an Arabidopsis ethylene response factor (ERF) gene, RAP2.6, in a coronatine insensitive 1 (COI1)-dependent manner. A highly sensitive RAP2...
  46. ncbi Identification and biochemical characterization of Rap2C, a new member of the Rap family of small GTP-binding proteins
    Simona Paganini
    Center of Excellence for Applied Biology, Department of Biochemistry, University of Pavia, via Bassi 21, 27100 Pavia, Italy
    Biochimie 88:285-95. 2006
    The Rap family of small GTP-binding proteins is composed by four different members: Rap1A, Rap1B, Rap2A and Rap2B. In this work we report the identification and characterization of a fifth member of this family of small GTPases...
  47. pmc Identification and characterization of putative tumor suppressor NGB, a GTP-binding protein that interacts with the neurofibromatosis 2 protein
    Hansoo Lee
    Department of Pathology, H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
    Mol Cell Biol 27:2103-19. 2007
    ..Caenorhabditis elegans, and human cells, and its GTP-binding region is very similar to those found in R-ras and Rap2. However, ectopic expression of NGB inhibits cell growth, cell aggregation, and tumorigenicity in tumorigenic ..
  48. ncbi Warm and cold parental reproductive environments affect seed properties, fitness, and cold responsiveness in Arabidopsis thaliana progenies
    C Blödner
    Institut fur Forstbotanik, Georg August Universitat, Gottingen, Germany
    Plant Cell Environ 30:165-75. 2007
    ..9 (PRR9) and down-regulation of growth-associated transcription factors (TFs) NAP and AP2domain containing RAP2.3...
  49. pmc Functional identification of Arabidopsis stress regulatory genes using the controlled cDNA overexpression system
    Csaba Papdi
    Institute of Plant Biology, Biological Research Centre, 6726 Szeged, Hungary
    Plant Physiol 147:528-42. 2008
    ..activation of stress- and ABA-inducible ADH1-LUC reporter gene has identified the ERF/AP2-type transcription factor RAP2.12, which sustained high-level ADH1-LUC bioluminescence, enhanced ADH1 transcription rate, and increased ADH enzyme ..
  50. doi Krit1 modulates beta 1-integrin-mediated endothelial cell proliferation
    Jun Zhang
    Department of Neurosurgery, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    Neurosurgery 63:571-8; discussion 578. 2008
    Using ribonucleic acid interference on cultured cell lines, we examined the role of Krev interaction trapped 1 (krit1) and integrin cytoplasmic domain-associated protein-1 alpha (icap1alpha) in beta1-integrin-mediated cell proliferation.
  51. doi Arabidopsis thaliana BTB/ POZ-MATH proteins interact with members of the ERF/AP2 transcription factor family
    Henriette Weber
    Washington State University, Pullman, WA 99164, USA
    FEBS J 276:6624-35. 2009
    ..This work connects, for the first time, BPM proteins with ethylene response factor/Apetala2 family members, which is likely to represent a novel regulatory mechanism of transcriptional control...
  52. pmc Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development
    Hiroshi Kawabe
    Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Gottingen, Germany
    Neuron 65:358-72. 2010
    ..Nedd4-1, the serine/threonine kinase TNIK, and Rap2A form a complex that controls Nedd4-1-mediated ubiquitination of Rap2A...
  53. pmc Ras and Rap signaling in synaptic plasticity and mental disorders
    Ruth L Stornetta
    Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia, USA
    Neuroscientist 17:54-78. 2011
    The Ras family GTPases (Ras, Rap1, and Rap2) and their downstream mitogen-activated protein kinases (ERK, JNK, and p38MAPK) and PI3K signaling cascades control various physiological processes...
  54. doi Structural determinants allowing endolysosomal sorting and degradation of endosomal GTPases
    Ruth A Valero
    Department of Chemical and Physical Biology, Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, 28040 Madrid, Spain
    Traffic 11:1221-33. 2010
    ..Other isoprenylated and bipalmitoylated GTPases, such as H-Ras, Rap2A, Rap2B and TC10, were not accumulated into MVB and were stable...
  55. doi Functional characterization of four APETALA2-family genes (RAP2.6, RAP2.6L, DREB19 and DREB26) in Arabidopsis
    Sowmya Krishnaswamy
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, T6G 2P5, Canada
    Plant Mol Biol 75:107-27. 2011
    ..Here, we report functional characterization of four AP2 TF family genes [(RAP2.6 (At1g43160), RAP2...
  56. pmc Structural basis for small G protein effector interaction of Ras-related protein 1 (Rap1) and adaptor protein Krev interaction trapped 1 (KRIT1)
    Xiaofeng Li
    Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 287:22317-27. 2012
    ..1-0.5% of the population resulting in leaky vasculature and severe neurological defects. KRIT1 (Krev interaction trapped-1) mutations associate with ∼40% of familial CCMs...
  57. doi RAP2.6L overexpression delays waterlogging induced premature senescence by increasing stomatal closure more than antioxidant enzyme activity
    Peiqing Liu
    State Ministry of Education Key Laboratory of Integrated Management of Crop Pests, Nanjing Agricultural University, Nanjing 210095, China
    Plant Mol Biol 79:609-22. 2012
    ..b>RAP2.6L (At5g13330) overexpression enhances plant resistance to jasmonic acid, salicylic acid, abscisic acid (ABA) and ..
  58. pmc Mechanism for KRIT1 release of ICAP1-mediated suppression of integrin activation
    Weizhi Liu
    Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Mol Cell 49:719-29. 2013
    KRIT1 (Krev/Rap1 Interaction Trapped-1) mutations are observed in ∼40% of autosomal-dominant cerebral cavernous malformations (CCMs), a disease occurring in up to 0.5% of the population...
  59. doi Neurotoxicity and gene-expressed profile in brain-injured mice caused by exposure to titanium dioxide nanoparticles
    Yuguan Ze
    Medical College, Soochow University, Suzhou, 215123, China
    J Biomed Mater Res A 102:470-8. 2014
    ..in Col1a1, serine/threonine-protein kinase 1, Ctnnb1, cysteine-serine-rich nuclear protein-1, Ddit4, Cyp2e1, and Krev interaction trapped protein 1 (Krit1) expressions and great decreases in DA receptor D2, Neu1, Fc receptor-like ..
  60. doi Rap G protein signal in normal and disordered lymphohematopoiesis
    Nagahiro Minato
    Department of Immunology and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Exp Cell Res 319:2323-8. 2013
    Rap proteins (Rap1, Rap2a, b, c) are small molecular weight GTPases of the Ras family. Rap G proteins mediate diverse cellular events such as cell adhesion, proliferation, and gene activation through various signaling pathways...
  61. pmc Structural basis for type VI secreted peptidoglycan DL-endopeptidase function, specificity and neutralization in Serratia marcescens
    Velupillai Srikannathasan
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland
    Acta Crystallogr D Biol Crystallogr 69:2468-82. 2013
    ..The structures of two immunity proteins, Rap1a and Rap2a, responsible for the neutralization of Ssp1 and Ssp2-like endopeptidases, respectively, revealed two distinct ..
  62. pmc Association of cardiovascular risk factors with disease severity in cerebral cavernous malformation type 1 subjects with the common Hispanic mutation
    Helene Choquet
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, Calif, USA
    Cerebrovasc Dis 37:57-63. 2014
    ..Familial CCM type 1 (CCM1) is an autosomal dominant disease caused by mutations in the Krev Interaction Trapped 1 (KRIT1/CCM1) gene, and is characterized by multiple brain lesions whose number and size ..
  63. pmc Mechanisms of isoform specific Rap2 signaling during enterocytic brush border formation
    Lucas J M Bruurs
    Molecular Cancer Research and Cancer Genomics Netherlands, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 9:e106687. 2014
    Brush border formation during polarity establishment of intestinal epithelial cells is uniquely governed by the Rap2A GTPase, despite expression of the other highly similar Rap2 isoforms (Rap2B and Rap2C)...
  64. pmc KRIT1 protein depletion modifies endothelial cell behavior via increased vascular endothelial growth factor (VEGF) signaling
    Peter V DiStefano
    From the Department of Pharmacology and Physiology, University of Rochester, Rochester, New York 14642
    J Biol Chem 289:33054-65. 2014
    ..The CCM (cerebral cavernous malformation) family of proteins (KRIT1 (Krev-interaction trapped 1), PDCD10, and CCM2) are critical regulators of endothelial cell-cell contact and vascular ..
  65. pmc PAK1 regulates RUFY3-mediated gastric cancer cell migration and invasion
    G Wang
    Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang 110001, China
    Cell Death Dis 6:e1682. 2015
    ..Although RUFY3 (RUN and FYVE domain containing 3)/SINGAR1 (single axon-related1)/RIPX (Rap2 interacting protein X) has an important role in neuronal development, its pathophysiologic role and relevance to ..
  66. doi The low oxygen, oxidative and osmotic stress responses synergistically act through the ethylene response factor VII genes RAP2.12, RAP2.2 and RAP2.3
    Csaba Papdi
    Biological Research Centre, Institute of Plant Biology, Temesvari krt 62, H 6726, Szeged, Hungary
    Plant J 82:772-84. 2015
    The ethylene response factor VII (ERF-VII) transcription factor RELATED TO APETALA2.12 (RAP2.12) was previously identified as an activator of the ALCOHOL DEHYDROGENASE1 promoter::luciferase (ADH1-LUC) reporter gene...
  67. ncbi Role of Rap2 and its Downstream Effectors in Tumorigenesis
    Hui Huang
    Department of Radiation Oncology and Lineberger Comprehensive Cancer Center, School of Medicine, The University of North Carolina at Chapel Hill, 101 Manning, Drive, Chapel Hill, NC 27514, USA
    Anticancer Agents Med Chem 15:1269-76. 2015
    b>Rap2, a member of the GTP-binding proteins, is widely upregulated in many types of tumors...
  68. doi RAP-PCR fingerprinting reveals time-dependent expression of development-related genes following differentiation process of Bacillus thuringiensis
    Tianpei Huang
    a Key Laboratory of Biopesticide and Chemical Biology, Ministry of Education, Fujian Agriculture and Forestry University, 350002 Fuzhou, Fujian, People s Republic of China
    Can J Microbiol 61:683-90. 2015
    ..b>RAP2 was homologous to a ClpX protease and an ATP-dependent protease La (LonB), which likely acted as virulence factors...
  69. pmc Structural analysis of the KRIT1 ankyrin repeat and FERM domains reveals a conformationally stable ARD-FERM interface
    Rong Zhang
    Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    J Struct Biol 192:449-56. 2015
    ..9 Å crystal structure of the ankyrin repeat domain (ARD) and FERM domain of the protein product of KRIT1 (KRIT1; Krev interaction trapped 1). The crystal structure reveals that the KRIT1 ARD contains 4 ankyrin repeats...
  70. pmc miR-9 and miR-124 synergistically affect regulation of dendritic branching via the AKT/GSK3β pathway by targeting Rap2a
    Qian Xue
    Institute of Neurosciences, The Fourth Military Medical University, Xi an 710032, China
    Sci Rep 6:26781. 2016
    ..In this study, we identified the small GTP-binding protein Rap2a as a common target of both miR-9 and miR-124...
  71. doi Universal stress protein HRU1 mediates ROS homeostasis under anoxia
    Silvia Gonzali
    PlantLab, Institute of Life Sciences, Scuola Superiore Sant Anna, Via Mariscoglio 34, Pisa 56124, Italy
    Nat Plants 1:15151. 2015
    ..universal stress protein (USP), Hypoxia Responsive Universal Stress Protein 1 (HRU1), is induced by RAP2.12 (Related to Apetala 2.12), an ERF-VII protein, and modulates ROS production in Arabidopsis...
  72. ncbi Oncogenic ras induces an inhibitor of double-stranded RNA-dependent eukaryotic initiation factor 2 alpha-kinase activation
    L J Mundschau
    Boston University School of Medicine, Cancer Research Center, Massachusetts 02118
    J Biol Chem 267:23092-8. 1992
    ..produced the effect within 18 h of induction; 2) morphologic reversion of ras-transformed cells with cAMP or the Krev-1 gene restored potential for dsI activation; and 3) transformation by v-mos or v-abl had no effect on dsI ..
  73. ncbi Organization and chromosomal locations of Rap1a/Krev sequences in the mouse
    N A Dower
    Department of Paediatrics, University of Alberta, Edmonton, Canada
    Mamm Genome 3:162-7. 1992
    ..Rap1a-rs2 is more distantly related to the gene sequence and is located on Chr 2 near Actc-1...
  74. pmc RAP2B: a RAS-related GTP-binding protein from platelets
    C A Ohmstede
    Division of Cell Biology, Burroughs Wellcome Co, Research Triangle Park, NC 27709
    Proc Natl Acad Sci U S A 87:6527-31. 1990
    ..analysis of one clone revealed that it encoded a partial amino acid sequence of a protein closely related to RAP2, which we have named RAP2B...
  75. ncbi Transformation suppressor genes
    M Noda
    Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Ibaraki, Japan
    Princess Takamatsu Symp 20:233-9. 1989
    ..We have recovered from one such revertant a 1.8 kb cDNA clone, "Krev-1", that possesses revertant-inducing activity in transfection assay...
  76. ncbi A ras-related gene with transformation suppressor activity
    H Kitayama
    Laboratory of Molecular Oncology, Tsukuba Life Science Center, Ibaraki, Japan
    Cell 56:77-84. 1989
    A 1.8 kb cDNA clone, Krev-1, with revertant-inducing activity on Kirsten sarcoma virus-transformed NIH/3T3 cells, has been isolated from a human fibroblast cDNA expression library...
  77. pmc Characterization of a guanine nucleotide dissociation stimulator for a ras-related GTPase
    C F Albright
    Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142
    EMBO J 12:339-47. 1993
    ..than on any other GTPase tested, including other members of the ras family (H-ras, N-ras, K-ras, R-ras, rap1a and rap2), members of the rho family (rhoA, rhoB and CDC42-Hs) and members of the rab family (rab3a and ypt1)...
  78. ncbi Localization of rap1 and rap2 proteins in the gelatinase-containing granules of human neutrophils
    F Mollinedo
    Centro de Investigaciones Biologicas, C S I C, Madrid, Spain
    FEBS Lett 326:209-14. 1993
    ..Neither rap1 nor rap2 proteins were found in the cytosol or in azurophilic granules. Rap2B, not rap2A, appeared to be the major rap2 protein in human neutrophils...
  79. ncbi Cloning of the murine Krit1 cDNA reveals novel mammalian 5' coding exons
    J Zhang
    Howard Hughes Medical Institute and The Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Genomics 70:392-5. 2000
    Human KRIT1 (Krev interaction trapped 1), a defective gene product in cerebral cavernous malformation, was cloned from a HeLa cell cDNA library by virtue of its interaction with Krev/rap1A, a small ras-family GTPase...
  80. ncbi Skipping in a hybrid polyketide synthase. Evidence for ACP-to-ACP chain transfer
    Iain Thomas
    Cambridge Centre for Molecular Recognition and Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, CB2 1GA, Cambridge, United Kingdom
    Chem Biol 9:781-7. 2002
    ..module (LM), the extension modules erythromycin module 1, rapamycin module 2, and erythromycin module 2 (LM-Ery1-Rap2-Ery2-TE), when expressed in Saccharopolyspora erythraea strain JC2, produced as previously reported a mixture of ..
  81. ncbi High glucose stimulates synthesis of fibronectin via a novel protein kinase C, Rap1b, and B-Raf signaling pathway
    Sun Lin
    Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Biol Chem 277:41725-35. 2002
    ..HG-induced activation of Rap1b was specific, since Rap2b activation and expression of Rap2a and Rap2b were unaffected by HG...
  82. ncbi Cloning, expression, and genomic structure of a novel human Rap2 interacting gene (RPIP9)
    Shu Wang
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, People s Republic of China
    Biochem Genet 41:13-25. 2003
    During a large-scale screen of a human fetal brain cDNA library, a full-length cDNA encoding a novel Rap2 interacting protein was isolated and sequenced...
  83. ncbi Epac: a new cAMP target and new avenues in cAMP research
    Johannes L Bos
    Department for Physiological Chemistry and Centre for Biomedical Genetics, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Nat Rev Mol Cell Biol 4:733-8. 2003
    Five years ago, Epac--a guanine nucleotide exchange factor for the Ras-like small GTPases Rap1 and Rap2--was found to be a new target of cyclic AMP, which opened up new avenues for cAMP research...
  84. ncbi Transformation of immortalized colorectal crypt cells by microcystin involving constitutive activation of Akt and MAPK cascade
    Yongliang Zhu
    Department of Gastroenterology and Cancer Institute, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
    Carcinogenesis 26:1207-14. 2005
    ..cells, PI3K, MAPKAPK2, Akt, cyclin D1 and cyclin D3 in the Akt pathway; IQGAP-2, RabGTPase, Rap1GAP, RasGAP, R-Ras, Krev-1 and TC21 of the Ras GTP/GDP protein family; and A-Raf, B-Raf and PAK in the Ras/MAPK pathway were all markedly ..
  85. ncbi Isogene specific oligo arrays reveal multifaceted changes in gene expression during grape berry (Vitis vinifera L.) development
    Nancy Terrier
    Unité Mixte de Recherche S P O, Biologie Intégrative de la Vigne et du Raisin, I N R A, 2 place Viala, 34060, Montpellier Cedex 1, France
    Planta 222:832-47. 2005
    ..Transcription factor analysis revealed the induction of RAP2 and WRKY genes at véraison, suggesting increasing biotic and abiotic stress conditions during ripening...
  86. ncbi A novel deletion mutation in CCM1 gene (krit1) is detected in a Chinese family with cerebral cavernous malformations
    Bao Hu Ji
    Key Laboratory of Biotechnology, College of Life Science, Ningxia University, Yinchuan 750021, China
    Yi Chuan Xue Bao 33:105-10. 2006
    ..At present, CCM1 (7q21), CCM2 (7p13-p15) and CCM3 (3q25.2-q27) are respectively linked to krit1 (Krev interaction trapped gene 1), MGC4607 and PDCD10 (programmed cell death 10)...
  87. ncbi Crystal structure of the RUN domain of the RAP2-interacting protein x
    Mutsuko Kukimoto-Niino
    RIKEN Genomic Sciences Center, Yokohama 230 0045, Japan
    J Biol Chem 281:31843-53. 2006
    b>Rap2-interacting protein x (RPIPx) is a homolog of RPIP8, a specific effector of Rap2 GTPase. The N-terminal region of RPIP8, which contains the RUN domain, interacts with Rap2...
  88. pmc XRab40 and XCullin5 form a ubiquitin ligase complex essential for the noncanonical Wnt pathway
    Rebecca Hui Kwan Lee
    Department of Developmental Biology, National Institute for Basic Biology, Okazaki, Aichi, Japan
    EMBO J 26:3592-606. 2007
    ..XRab40/XCullin5 functions cooperatively and regulates the ubiquitination and localization of Rap2 GTPase...
  89. pmc Transcription factor RAP2.2 and its interacting partner SINAT2: stable elements in the carotenogenesis of Arabidopsis leaves
    Ralf Welsch
    Faculty of Biology, Center for Applied Biosciences, Universitat Freiburg, 79104 Freiburg, Germany
    Plant Physiol 145:1073-85. 2007
    ..The action of SINAT2 may explain the recalcitrance of AtRAP2.2 protein levels to change by altering AtRAP2.2 transcription...
  90. doi Alterations of lysine modifications on the histone H3 N-tail under drought stress conditions in Arabidopsis thaliana
    Jong Myong Kim
    Plant Functional Genomics Research Group, RIKEN Plant Science Center, Tsurumi ku, Yokohama, Kanagawa, 230 0045 Japan
    Plant Cell Physiol 49:1580-8. 2008
    ....
  91. doi Molecular cloning and characterization of a novel ras-related protein (rap2) from Clonorchis sinensis
    Wenjun Chen
    Department of Parasitology, Zhongshan School of Medicine, Sun Yat Sen University, 74 Zhongshan 2nd Road, Guangzhou, 510080, People s Republic of China
    Parasitol Res 108:1021-6. 2011
    ..growth regulation in Clonorchis sinensis, we have identified a full-length sequence encoding a ras-related protein (rap2) from our adult cDNA library. The open reading frame contains 561 bp encoding 186 amino acids...
  92. doi Induction of smooth muscle cell migration during arteriogenesis is mediated by Rap2
    Jochen Pöling
    Department of Cardiac Development and Remodelling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany
    Arterioscler Thromb Vasc Biol 31:2297-305. 2011
    ..Arteriogenesis depends on activation of fibroblast growth factor (FGF) receptors, but relatively little is known about downstream mediators of FGF signaling...
  93. pmc Rap1GAP impairs cell-matrix adhesion in the absence of effects on cell-cell adhesion
    Lisa A Vuchak
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Cell Adh Migr 5:323-31. 2011
    ..Overexpression of Rap1GAP in human colon cancer cells impaired Rap2 activity and the ability of cells to spread and migrate on collagen IV...
  94. doi Making sense of low oxygen sensing
    Julia Bailey-Serres
    Center for Plant Cell Biology, Department of Botany and Plant Sciences, University of California, Riverside, CA 92521 0124, USA
    Trends Plant Sci 17:129-38. 2012
    ..Oxygen-dependent sequestration at the plasma membrane maintains at least one of these proteins, RAP2.12, under normoxia...
  95. pmc Micro-editing mistake translates into a devastating brain tumor
    Dan Dominissini
    Cancer Research Center, Chaim Sheba Medical Center, Tel Hashomer, Israel
    J Clin Invest 122:3842-5. 2012
    ..Moreover, RAP2A and AMFR convincingly emerge as key regulators of glioma migration and invasion affected by deregulated microRNA ..
  96. doi Small molecule-enrichment analysis in response to osmotic stimuli in the intervertebral disc
    H Ma
    Department of Orthopaedic Surgery, Shanghai First Rehabilitation Hospital, Shanghai, P R China
    Genet Mol Res 11:3668-75. 2012
    ..Based on microarray data, we concluded that RAP2A and GNA13 appear to have a role in response to osmotic stimuli in intervertebral discs...
  97. doi Proteome profiling of exosomes derived from human primary and metastatic colorectal cancer cells reveal differential expression of key metastatic factors and signal transduction components
    Hong Ji
    Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia
    Proteomics 13:1672-86. 2013
    ..A key finding of this study was the detection and colocalization of protein complexes EPCAM-CLDN7 and TNIK-RAP2A in colorectal cancer cell exosomes...
  98. doi HNF1b is involved in prostate cancer risk via modulating androgenic hormone effects and coordination with other genes
    Y L Hu
    Medical Scientific Research Centre, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China
    Genet Mol Res 12:1327-35. 2013
    ..Twelve genes (BAG1, DDR1, ERBB4, ESR1, HSPD1, IGFBP2, IGFBP5, NR4A1, PAWR, PIK3CG, RAP2A, and TPD52) were found to be associated with both HNF1b and prostate cancer risk...
  99. pmc Array analysis for potential biomarker of gemcitabine identification in non-small cell lung cancer cell lines
    Hai Hong Zhang
    Department of Rheumatism and Immunology, First Clinical Medical College affiliated to Harbin Medical University Harbin, China
    Int J Clin Exp Pathol 6:1734-46. 2013
    ..all the above genes were upregulated in sensitive cells) and small GTPase mediated signal transduction (GNA13, RAP2A, ARHGAP5 and RAB23, down-regulated in sensitive cells)...
  100. pmc Early transcriptional response of soybean contrasting accessions to root dehydration
    José Ribamar Costa Ferreira Neto
    Laboratory of Molecular Genetics, Genetics Department, Federal University of Pernambuco, Recife, Pernambuco, Brazil
    PLoS ONE 8:e83466. 2013
    ..Additionally, nine transcripts (HMGR, XET, WRKY20, RAP2-4, EREBP, NAC3, PER, GPX5 and BMY) validated by RT-qPCR (four different time points) confirmed their differential ..
  101. pmc Trans-dimerization of JAM-A regulates Rap2 and is mediated by a domain that is distinct from the cis-dimerization interface
    Ana C Monteiro
    Epithelial Pathobiology and Mucosal Inflammation Research Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322
    Mol Biol Cell 25:1574-85. 2014
    ..of JAM-A dimerization on cell signaling revealed that expression of trans- but not cis-null JAM-A mutants decreased Rap2 activity. Furthermore, confluent cells, which enable trans-dimerization, had enhanced Rap2 activity...

Research Grants15

  1. John R Hepler; Fiscal Year: 2016
    ..guanine- nucleotide exchange factor activator for G1i, and also to inactive Gi11/3-GDP, active H-Ras and Rap2 and their effectors the Raf kinases...
  2. Investigating the Role of Malaria Rhoptry-Associated Protein 2 in Severe Anemia
    NOE DAVID GOMEZ; Fiscal Year: 2010
    ..The specific hypothesis driving this proposed research is that a protein called rhoptry-associated protein 2 (RAP2) plays a central role in the onset of SMA...
  3. RGS proteins as novel integrators of G protein and MAPK signaling
    JOHN HEPLER; Fiscal Year: 2009
    ..is a highly unusual, multifunctional signaling protein that binds active Gi/oa subunits, inactive Gia subunits and Rap2, a Ras-like GTPase...
  4. Role of Programmed Cell Death10 (PDCD10) in p38 MAP kinase activation and PDK1 si
    Sompop Bencharit; Fiscal Year: 2010
    ..They encode three CCM proteins: Krit1 (Krev interaction trapped-1), OSM (Osmosensing scaffold for MEKK3 or malcalvernin), and PDCD10 (Programmed cell death 10)...
  5. Rytis Prekeris; Fiscal Year: 2016
    ..Second, FIP5-dependent endocytic transport of Rap2A mediates microvilli formation in polarized epithelial cells...
  6. David A Calderwood; Fiscal Year: 2016
    ..Regulation of the Cerebral Cavernous Malformation Complex ABSTRACT Loss of function of the three proteins, KRIT1 (Krev/Rap1 Interacting Trapped 1;CCM1, cerebral cavernous malformation 1), CCM2 (cerebral cavernous malformation 2;OSM, ..
  7. Exploring RGS14 signaling functions in the CA2 hippocampus
    John R Hepler; Fiscal Year: 2012
    ..specific domains that bind active Gi/o1-GTP (RGS domain), inactive Gi11/2-GDP (GPR/GL domain) and active H-Ras/Rap2 and Raf (tandem Ras binding domains, or RBD)...
  8. Mechanisms of Synaptic Depression: Focus on Rap Signaling Pathways
    J Julius Zhu; Fiscal Year: 2010
    ..In a preliminary study, we observed that small GTPase Rap2 controls depotentiation via activation of JNK...
  9. PATHOLOGY IN ANTICANCER/CANCER SUPPRESSOR REGULATION
    Robert Scott; Fiscal Year: 1993
    ..e. Krev-1 and rrg. Despite the unequivocal importance of these observations, a very important question remains unanswered...
  10. PHOSPHOLIPASE C AND ISLET BETA CELLS
    GRANT KELLEY; Fiscal Year: 2002
    ..This novel signaling pathway may play a critical role in glucose and hormone stimulated insulin secretion and beta cell function. ..
  11. LH ACTION IN OVARIAN CELL DIFFERENTIATION
    Joanne Richards; Fiscal Year: 2007
    ..A related and longer term goal of the research is to identify and characterize the genes regulated by LH, prostaglandins (PGs), and C/EBPs that control key steps in the ovulatory process. ..
  12. Synaptic Glutamate Release in Drosphila
    Aaron DiAntonio; Fiscal Year: 2008
    ..The results of these experiments will provide novel and fundamental information on the mechanisms by which VGLUT contributes to the development and function of glutamatergic synapses. ..
  13. Ovarian Follicular Developmental and Hormone Action
    Joanne Richards; Fiscal Year: 2007
    ..3) Determine the molecular, cellular and hormonal basis of the altered ovarian phenotype of the TAFII105 null mice. 4) Determine the function of Wnt-4 in the adult ovary. ..
  14. LH ACTION IN OVARIAN CELL DIFFERENTIATION
    Joanne Richards; Fiscal Year: 2008
    ..Specific Aim II: Determine the function of AREG target genes that are uniquely expressed at high levels in ovulated COCs (compared to granulosa cells) and that impact ovulation. ..

Patents1

  1. NOVEL PROTEINS, DNA CODING FOR SAID PROTEINS, AND THEIR USE
    Patent Number: WO9000179-A2; Date:1990-01-11