RAP1B

Summary

Gene Symbol: RAP1B
Description: RAP1B, member of RAS oncogene family
Alias: K-REV, RAL1B, ras-related protein Rap-1b, GTP-binding protein smg p21B, RAS-related protein RAP1B, Ras family small GTP binding protein RAP1B, small GTP binding protein
Species: human

Top Publications

  1. ncbi Contribution of protease-activated receptors 1 and 4 and glycoprotein Ib-IX-V in the G(i)-independent activation of platelet Rap1B by thrombin
    Paolo Lova
    Center of Excellence in Applied Biology, Department of Biochemistry, University of Pavia, via Bassi 21, 27100 Pavia
    J Biol Chem 279:25299-306. 2004
  2. pmc Phosphorylation-induced conformational changes in Rap1b: allosteric effects on switch domains and effector loop
    Martin M Edreira
    Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 284:27480-6. 2009
  3. doi miR-518b is down-regulated, and involved in cell proliferation and invasion by targeting Rap1b in esophageal squamous cell carcinoma
    Mingxin Zhang
    Department of Thoracic Oncosurgery, First Affiliated Hospital, Medical School, Xi an Jiaotong University, Xi an 710061, Shaanxi Province, China
    FEBS Lett 586:3508-21. 2012
  4. ncbi The GTPase-activating protein Rap1GAP uses a catalytic asparagine
    Oliver Daumke
    Max Planck Institut fur molekulare Physiologie, Otto Hahnstr 11, 44227 Dortmund, Germany
    Nature 429:197-201. 2004
  5. ncbi Isolation and analysis of functional homologues of the secretion-related SAR1 gene of Saccharomyces cerevisiae from Aspergillus niger and Trichoderma reesei
    G Veldhuisen
    Department of Molecular Genetics and Gene Technology, TNO Nutrition and Food Research Institute, Zeist, The Netherlands
    Mol Gen Genet 256:446-55. 1997
  6. ncbi The Gem GTP-binding protein promotes morphological differentiation in neuroblastoma
    A Leone
    Cell and Cancer Biology Department, Medicine Branch, Division of Clinical Sciences, National Cancer Institute, Building 10, Room 3B43, 9000, Rockville Pike, Bethesda, Maryland, MD 20892, USA
    Oncogene 20:3217-25. 2001
  7. doi Analysis of pulmonary vasodilator responses to the Rho-kinase inhibitor fasudil in the anesthetized rat
    Adeleke M Badejo
    Department of Pharmacology SL83, Tulane University Health Sciences Center, 1430 Tulane Ave, New Orleans, LA 70112, USA
    Am J Physiol Lung Cell Mol Physiol 295:L828-36. 2008
  8. ncbi Cloning, expression, and characterization of a novel phospholipase D complementary DNA from rat brain
    T Kodaki
    Department of Biochemistry, Gunma University School of Medicine, Maebashi 371, Japan
    J Biol Chem 272:11408-13. 1997
  9. ncbi Identification of Rab3A GTPase as an acrosome-associated small GTP-binding protein in rat sperm
    H Iida
    Faculty of Agriculture, Kyushu University, Higashi ku, Fukuoka, 812 8581, Japan
    Dev Biol 211:144-55. 1999
  10. ncbi RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG
    G Zalcman
    Unité INSERM 248, Section de Recherche, Institut Curie, 26 Rue d Ulm, 75231 Paris Cedex 05, France
    J Biol Chem 271:30366-74. 1996

Research Grants

  1. Regulation of Neuronal Survival by the Rit GTPase
    DOUGLAS ALLEN ANDRES; Fiscal Year: 2012
  2. JAMES RICHARD GOLDENRING; Fiscal Year: 2016
  3. Inorganic phosphate regulated proliferation, transformation and tumorigenesis
    George R Beck; Fiscal Year: 2013
  4. The Role of FKBP38 in tumorigenesis associated with Tsc deficiency
    Yu Jiang; Fiscal Year: 2012
  5. MARIA IRENE KONTARIDIS; Fiscal Year: 2014
  6. Ras and Phosphoinositide 3-kinase Signaling in Lens Development
    Lixing W Reneker; Fiscal Year: 2012
  7. Sympathetic Control in Heart Failure: A Role of Statins
    Irving H Zucker; Fiscal Year: 2010
  8. Magdalena Chrzanowska; Fiscal Year: 2016
  9. Novel Insulin Signals Regulating GLUT4 Translocation
    Jeffrey Pessin; Fiscal Year: 2005
  10. Determining the rap1b signaling pathway to integrin activation in platelets
    LUIS ALBERTO PANIAGUA; Fiscal Year: 2012

Patents

  1. NOVEL PROTEINS, DNA CODING FOR SAID PROTEINS, AND THEIR USE

Detail Information

Publications277 found, 100 shown here

  1. ncbi Contribution of protease-activated receptors 1 and 4 and glycoprotein Ib-IX-V in the G(i)-independent activation of platelet Rap1B by thrombin
    Paolo Lova
    Center of Excellence in Applied Biology, Department of Biochemistry, University of Pavia, via Bassi 21, 27100 Pavia
    J Biol Chem 279:25299-306. 2004
    ..We investigated the contribution of these three receptors to thrombin-induced activation of the small GTPase Rap1B. We found that, similarly to thrombin, selective stimulation of either PAR-1 or PAR-4 by specific activating ..
  2. pmc Phosphorylation-induced conformational changes in Rap1b: allosteric effects on switch domains and effector loop
    Martin M Edreira
    Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 284:27480-6. 2009
    b>Rap1b has been implicated in the transduction of the cAMP mitogenic response. Agonists that increase intracellular cAMP rapidly activate (i.e. GTP binding) and phosphorylate Rap1b on Ser(179) at its C terminus...
  3. doi miR-518b is down-regulated, and involved in cell proliferation and invasion by targeting Rap1b in esophageal squamous cell carcinoma
    Mingxin Zhang
    Department of Thoracic Oncosurgery, First Affiliated Hospital, Medical School, Xi an Jiaotong University, Xi an 710061, Shaanxi Province, China
    FEBS Lett 586:3508-21. 2012
    ..Furthermore, Rap1b was revealed to be directly regulated by miR-518b...
  4. ncbi The GTPase-activating protein Rap1GAP uses a catalytic asparagine
    Oliver Daumke
    Max Planck Institut fur molekulare Physiologie, Otto Hahnstr 11, 44227 Dortmund, Germany
    Nature 429:197-201. 2004
    ..9 A. By mutational analysis, fluorescence titration and stopped-flow kinetic assay, we demonstrate that Rap1GAP provides a catalytic asparagine to stimulate GTP hydrolysis. Implications for the disease tuberous sclerosis are discussed...
  5. ncbi Isolation and analysis of functional homologues of the secretion-related SAR1 gene of Saccharomyces cerevisiae from Aspergillus niger and Trichoderma reesei
    G Veldhuisen
    Department of Molecular Genetics and Gene Technology, TNO Nutrition and Food Research Institute, Zeist, The Netherlands
    Mol Gen Genet 256:446-55. 1997
    ..This result contrasts with the situation in S. cerevisiae, where similar mutations have a thermosensitive phenotype. Taken together, our results indicate that the sarA gene is involved in an essential function in A. niger...
  6. ncbi The Gem GTP-binding protein promotes morphological differentiation in neuroblastoma
    A Leone
    Cell and Cancer Biology Department, Medicine Branch, Division of Clinical Sciences, National Cancer Institute, Building 10, Room 3B43, 9000, Rockville Pike, Bethesda, Maryland, MD 20892, USA
    Oncogene 20:3217-25. 2001
    ....
  7. doi Analysis of pulmonary vasodilator responses to the Rho-kinase inhibitor fasudil in the anesthetized rat
    Adeleke M Badejo
    Department of Pharmacology SL83, Tulane University Health Sciences Center, 1430 Tulane Ave, New Orleans, LA 70112, USA
    Am J Physiol Lung Cell Mol Physiol 295:L828-36. 2008
    ....
  8. ncbi Cloning, expression, and characterization of a novel phospholipase D complementary DNA from rat brain
    T Kodaki
    Department of Biochemistry, Gunma University School of Medicine, Maebashi 371, Japan
    J Biol Chem 272:11408-13. 1997
    ..Only a negligible level was found in spleen and pancreas. Thus rPLD2 is a novel type of PLD dependent on phosphatidylinositol 4,5-bisphosphate, but not on the small GTP-binding proteins ADP-ribosylation factor 1 and RhoA...
  9. ncbi Identification of Rab3A GTPase as an acrosome-associated small GTP-binding protein in rat sperm
    H Iida
    Faculty of Agriculture, Kyushu University, Higashi ku, Fukuoka, 812 8581, Japan
    Dev Biol 211:144-55. 1999
    ..In view of the putative role of Rab3A protein in membrane fusion systems, these results suggest that Rab3A could be involved in regulating the mammalian acrosome reaction by controlling the membrane fusion system in sperm...
  10. ncbi RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG
    G Zalcman
    Unité INSERM 248, Section de Recherche, Institut Curie, 26 Rue d Ulm, 75231 Paris Cedex 05, France
    J Biol Chem 271:30366-74. 1996
    ..No interaction is found with RhoA, RhoC, or Rac1 proteins. We show that GDI-3 is able to inhibit GDP/GTP exchange of RhoB and to release GDP-bound but not GTP-bound RhoB from cell membranes...
  11. pmc Phosphoinositide 3-kinase p110 beta regulates integrin alpha IIb beta 3 avidity and the cellular transmission of contractile forces
    Simone M Schoenwaelder
    Australian Centre for Blood Diseases, Monash University, Alfred Medical Research and Education Precinct, 89 Commercial Road, Melbourne, Victoria 3004, Australia
    J Biol Chem 285:2886-96. 2010
    ..primarily occurs downstream of G(i)-coupled and tyrosine kinase-linked receptors linked to the activation of Rap1b, AKT, and phospholipase C...
  12. ncbi The small GTP-binding protein rho activates c-Jun N-terminal kinases/stress-activated protein kinases in human kidney 293T cells. Evidence for a Pak-independent signaling pathway
    H Teramoto
    Laboratory of Cellular Development and Oncology, NIDR, National Institutes of Health, Bethesda, Maryland 20892 4330, USA
    J Biol Chem 271:25731-4. 1996
    ....
  13. doi Investigation of the role of oligopeptide transporter PEPT1 and sodium/glucose cotransporter SGLT1 in intestinal absorption of their substrates using small GTP-binding protein Rab8-null mice
    Yukio Kato
    Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
    Drug Metab Dispos 37:602-7. 2009
    ..The present findings also illustrate the pharmacokinetic influence of the sorting machinery protein Rab8...
  14. pmc Regulation by Rab3A of an endogenous modulator of neurotransmitter release at mouse motor nerve endings
    Jody K Hirsh
    Department of Molecular Pharmacology and Biological Chemistry S 215, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, IL 60611, USA
    J Physiol 545:337-43. 2002
    ..CPT had no effect on the pattern of responses recorded during repetitive stimulation in either strain. The results suggest that Rab3A reduces the potency of adenosine as an endogenous mediator of neuromuscular depression...
  15. ncbi ADP-ribosylation factor-directed GTPase-activating protein. Purification and partial characterization
    V Makler
    Department of Biology, Technion Israel Institute of Technology, Haifa
    J Biol Chem 270:5232-7. 1995
    ..A., and Kahn, R. A. (1994) J. Biol. Chem. 269, 10758). The availability of the ARF GAP molecule will advance the understanding of the regulation of the cellular processes in which ARF proteins participate...
  16. ncbi PKN associates and phosphorylates the head-rod domain of neurofilament protein
    H Mukai
    Department of Biology, Faculty of Science, Kobe University, Japan
    J Biol Chem 271:9816-22. 1996
    ..The identification and characterization of the novel interaction with PKN may contribute toward the elucidation of mechanisms regulating the function of neurofilament...
  17. ncbi The small GTP-binding protein Rho1 is a multifunctional protein that regulates actin localization, cell polarity, and septum formation in the fission yeast Schizosaccharomyces pombe
    K Nakano
    Graduate Program in Biophysics and Biochemistry, School of Science, University of Tokyo, Hongo, Japan
    Genes Cells 2:679-94. 1997
    ..We have previously isolated two rho genes, rho1+ and rho2+, from the fission yeast Schizosaccharomyces pombe in order to investigate the function of Rho using genetic techniques. In this paper, we report the cellular function of Rho1...
  18. ncbi Small GTP-binding protein Ral is involved in cAMP-mediated release of von Willebrand factor from endothelial cells
    Mariska G Rondaij
    Department of Plasma Proteins, Sanquin Research at CLB, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 24:1315-20. 2004
    ..In the present study, we investigated whether Ral is also involved in cAMP-mediated vWF release...
  19. doi Thrombin induces platelet activation in the absence of functional protease activated receptors 1 and 4 and glycoprotein Ib-IX-V
    Paolo Lova
    Department of Biochemistry, University of Pavia, via Bassi 21, 27100 Pavia, Italy
    Cell Signal 22:1681-7. 2010
    ..or by selective activating peptides stimulated phospholipase C, tyrosine kinases, as well as the small GTPase Rap1b, promoted actin polymerization and cytoskeleton reorganization...
  20. pmc A bacterial Ras-like small GTP-binding protein and its cognate GAP establish a dynamic spatial polarity axis to control directed motility
    Yong Zhang
    Institut de Microbiologie de la Méditerranée Université Aix Marseille Laboratoire de Chimie Bactérienne, Marseille, France
    PLoS Biol 8:e1000430. 2010
    ..In summary, our results provide insight into how bacteria regulate their polarity dynamically, revealing unsuspected conserved regulations with eukaryots...
  21. ncbi Enrichment of rab11, a small GTP-binding protein, in gastric parietal cells
    J R Goldenring
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut
    Am J Physiol 267:G187-94. 1994
    ..These results suggest that rab11 is enriched in parietal cells and is associated with intracellular tubulovesicles...
  22. ncbi Requirement for both the amino-terminal catalytic domain and a noncatalytic domain for in vivo activity of ADP-ribosylation factor GTPase-activating protein
    I Huber
    Department of Biology, Technion Israel Institute of Technology, Haifa 32000, Israel
    J Biol Chem 273:24786-91. 1998
    ..Thus, a noncatalytic domain is required for GAP activity in vivo. This domain may be involved in the targeting of GAP to the Golgi membrane...
  23. pmc An arf1Delta synthetic lethal screen identifies a new clathrin heavy chain conditional allele that perturbs vacuolar protein transport in Saccharomyces cerevisiae
    C Y Chen
    Department of Molecular Biology, Vanderbilt University, Nashville, Tennessee 37235, USA
    Genetics 150:577-89. 1998
    ....
  24. ncbi CysLT1 signal transduction in differentiated U937 cells involves the activation of the small GTP-binding protein Ras
    Valerie Capra
    Laboratory of Molecular Pharmacology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Biochem Pharmacol 67:1569-77. 2004
    ..In conclusion, LTD(4)-induced CysLT(1) receptor activation in dU937 cells leads to Ras activation and ERK phosphorylation mostly through a PTx-sensitive G(i/o) protein, PLC, and Ca(2+)-dependent tyrosine kinase(s)...
  25. ncbi beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis
    A Claing
    Howard Hughes Medical Institute and Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 276:42509-13. 2001
    ....
  26. ncbi The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
    A J Ridley
    Institute for Cancer Research, Chester Beatty Laboratories, London, England
    Cell 70:389-99. 1992
    ..These data imply that rho is essential specifically for the coordinated assembly of focal adhesions and stress fibers induced by growth factors...
  27. ncbi [RasGRP proteins--Ras-activating factors]
    Mateusz Szamałek
    Katedra Biochemii Farmaceutycznej, Uniwersytet Medyczny im K Marcinkowskiego, Poznan
    Postepy Biochem 53:112-20. 2007
    ..In this review, structure and function of RasGRP proteins, as well as their role in neoplastic transformation are described...
  28. ncbi Functional complementation of a yeast vesicular transport mutation ypt1-1 by a Brassica napus cDNA clone encoding a small GTP-binding protein
    Y S Park
    Department of Life Science, Pohang University of Science and Technology, Hyoja Dong, Kyungbuk, South Korea
    Plant Mol Biol 26:1725-35. 1994
    ..Genomic Southern analysis shows that this gene is a member of a small gene family in Brassica napus...
  29. pmc Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho
    T Matsui
    Division of Signal Transduction, Nara Institute of Science and Technology, Ikoma, Japan
    EMBO J 15:2208-16. 1996
    The small GTP binding protein Rho is implicated in cytoskeletal responses to extracellular signals such as lysophosphatidic acid to form stress fibers and focal contacts...
  30. ncbi Molecular characterization of an Arabidopsis thaliana cDNA encoding a small GTP-binding protein, Rha1
    S Anuntalabhochai
    Laboratorium voor Genetica, Universiteit Gent, Belgium
    Plant J 1:167-74. 1991
    ..Genomic Southern analysis revealed that rha 1 is part of a small multigene family...
  31. pmc C terminus of the small GTP-binding protein smg p25A contains two geranylgeranylated cysteine residues and a methyl ester
    C C Farnsworth
    Howard Hughes Medical Institute Laboratory, University of Washington, Seattle, WA 98195
    Proc Natl Acad Sci U S A 88:6196-200. 1991
    ....
  32. ncbi Gpa2p, a G-protein alpha-subunit, regulates growth and pseudohyphal development in Saccharomyces cerevisiae via a cAMP-dependent mechanism
    E Kübler
    Institut fur Mikrobiologie, Georg August Universitat Gottingen, D 37077 Gottingen, Germany
    J Biol Chem 272:20321-3. 1997
    ..Heterologous expression of mammalian G-protein alpha-subunits in these yeast GPA2 deletion strains could provide a valuable tool for the mutational analysis of mammalian G-protein function in an in vivo null setting...
  33. pmc The retinitis pigmentosa GTPase regulator, RPGR, interacts with the delta subunit of rod cyclic GMP phosphodiesterase
    M Linari
    Max Planck Institut fur molekulare Physiologie, Abteilung Strukturelle Biologie, Rheinlanddamm 201, Postfach 102664, D 44026 Dortmund, Germany
    Proc Natl Acad Sci U S A 96:1315-20. 1999
    ..These results suggest that RPGR mutations give rise to retinal degeneration by dysregulation of intracellular processes that determine protein localization and protein transport...
  34. pmc The golgi-associated COPI-coated buds and vesicles contain beta/gamma -actin
    F Valderrama
    Departament de Biologia Cellular, Facultat de Medicina, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Universitat de Barcelona, 08036 Barcelona, Spain
    Proc Natl Acad Sci U S A 97:1560-5. 2000
    ....
  35. ncbi Molecular cloning of a cDNA for a small GTP binding protein, BRho, from the embryo of Bombyx mori and its characterization after expression and purification
    T Uno
    Laboratory of Biological Chemistry, Department of Biofunctional Chemistry, Faculty of Agriculture, Kobe University, Nada Ku, Kobe, Hyogo, Japan
    Arch Insect Biochem Physiol 43:165-72. 2000
    A cDNA clone encoding a small GTP binding protein (Brho) was isolated from an embryonic cDNA library of Bombyx mori that encoded a polypeptide with 202 amino acids sharing 60-80% similarity with the Rho1 family of GTP binding proteins...
  36. ncbi Expression of Rab small GTPases in epithelial Caco-2 cells: Rab21 is an apically located GTP-binding protein in polarised intestinal epithelial cells
    F J Opdam
    Department of Cell Biology, Institute of Cellular Signalling, University of Nijmegen, The Netherlands
    Eur J Cell Biol 79:308-16. 2000
    ..We therefore suggest an alternative role for Rab21 in the regulation of vesicular transport in polarised intestinal epithelial cells...
  37. ncbi Centaurin-alpha 1, an ADP-ribosylation factor 6 GTPase activating protein, inhibits beta 2-adrenoceptor internalization
    Joanna Lawrence
    Department of Pharmacology, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, United Kingdom
    Mol Pharmacol 67:1822-8. 2005
    ..Thus, ARF6 GAPs, such as centaurin alpha(1), are likely to play a crucial role in GPCR trafficking by modulating the activity of ARF6...
  38. ncbi Nuclear localization of endogenous RGK proteins and modulation of cell shape remodeling by regulated nuclear transport
    Ramasubbu N Mahalakshmi
    Epithelial Cell Biology Laboratory, Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673, Singapore
    Traffic 8:1164-78. 2007
    ..e., cytoskeleton, endoplasmic reticulum or plasma membrane) is of physiological relevance for the regulation of RGK protein function...
  39. doi Role of inducible nitric oxide synthase in induction of RhoA expression in hearts from diabetic rats
    Hesham Soliman
    Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of British Columbia, 2146 East Mall, Vancouver, BC, Canada V6T 1Z3
    Cardiovasc Res 79:322-30. 2008
    ..Therefore, in this study, we investigated the hypothesis that induction of iNOS positively regulates RhoA expression in diabetic rat hearts...
  40. pmc In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase
    M Ren
    Department of Cell Biology, New York University School of Medicine, New York, 10016, USA
    Proc Natl Acad Sci U S A 93:5151-5. 1996
    ..Moreover, the rab8ip/GC kinase may serve to modulate secretion in response to stress stimuli...
  41. pmc Ethanol-induced retention of nascent proteins in rat hepatocytes is accompanied by altered distribution of the small GTP-binding protein rab2
    J M Larkin
    Center for Basic Research in Digestive Diseases, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Clin Invest 98:2146-57. 1996
    ..The effects of ethanol exposure on rab proteins and Golgi function are discussed...
  42. ncbi Increased immunoreactivity for Rab11, a small GTP-binding protein, in low-grade dysplastic Barrett's epithelia
    G S Ray
    Department of Medicine, Institute for Molecular Medicine and Genetics, Medical College of Georgia, Augusta 30912 3175, USA
    Lab Invest 77:503-11. 1997
    ....
  43. ncbi The small GTP-binding protein Rac promotes the dissociation of gelsolin from actin filaments in neutrophils
    A Arcaro
    Institute of Biochemistry, University of Fribourg, CH 1700 Fribourg, Switzerland
    J Biol Chem 273:805-13. 1998
    ..These findings suggest that activation of Rac by G-protein-coupled receptors in neutrophils triggers uncapping of actin filaments, independently of PI 3-kinase...
  44. ncbi Regulation of RhoA GTP hydrolysis by the GTPase-activating proteins p190, p50RhoGAP, Bcr, and 3BP-1
    B Zhang
    Department of Biochemistry, University of Tennessee, Memphis, Tennessee 38163, USA
    Biochemistry 37:5249-57. 1998
    ....
  45. ncbi Human rab11a: transcription, chromosome mapping and effect on the expression levels of host GTP-binding proteins
    P S Gromov
    Department of Medical Biochemistry and Danish Centre for Human Genome Research, Aarhus University, Denmark
    FEBS Lett 429:359-64. 1998
    ....
  46. ncbi Characterization of a desiccation-responsive small GTP-binding protein (Rab2) from the desiccation-tolerant grass Sporobolus stapfianus
    M J Oliver
    Plant Stress and Water Conservation Laboratory, USDA ARS, Lubbock, TX 79401, USA
    Plant Mol Biol 39:809-21. 1999
    ..A possible role for Rab2 with respect to desiccation tolerance and damage repair is discussed...
  47. ncbi Involvement of Rho-kinase pathway for angiotensin II-induced plasminogen activator inhibitor-1 gene expression and cardiovascular remodeling in hypertensive rats
    Naohiko Kobayashi
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    J Pharmacol Exp Ther 301:459-66. 2002
    ..Thus, inhibition of the Rho-kinase pathway may be at least a useful therapeutic strategy for treating cardiovascular remodeling...
  48. doi Guanine exchange factor RalGDS mediates exocytosis of Weibel-Palade bodies from endothelial cells
    Mariska G Rondaij
    Department of Plasma Proteins, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Blood 112:56-63. 2008
    ..Together our findings suggest that RalGDS plays a vital role in the regulation of Ral-dependent WPB exocytosis after stimulation with Ca(2+)- or cAMP-raising agonists...
  49. ncbi The ras-related small GTP-binding protein RhoB is immediate-early inducible by DNA damaging treatments
    G Fritz
    Institut fur Pharmakologie und Toxikologie, Universitat des Saarlandes, Homburg Saar, Federal Republic of Germany
    J Biol Chem 270:25172-7. 1995
    ..The data indicate that rhoB represents a novel DNA damage-inducible function involved in early steps of signal transduction upon genotoxic stress...
  50. ncbi Molecular cloning of a cDNA encoding a novel small GTP-binding protein
    T Koda
    Section of Bacterial Infection, Hokkaido University, Sapporo, Japan
    FEBS Lett 328:21-4. 1993
    ..Northern blot analysis revealed that this gene is expressed only in lymphoid cell lines and a histiocytic leukemia, U937. Hence, it should have a specialized function in cells derived from the hematopoietic stem cell...
  51. pmc Growth site localization of Rho1 small GTP-binding protein and its involvement in bud formation in Saccharomyces cerevisiae
    W Yamochi
    Department of Biochemistry, Kobe University School of Medicine, Japan
    J Cell Biol 125:1077-93. 1994
    ..These results suggest that Rho1 small GTP-binding protein binds to a specific site at the growth region of cells, where Rho1p exerts its function in controlling cell growth...
  52. ncbi Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1
    X F Zhang
    Diabetes Unit, Harvard Medical School, Charlestown, Massachusetts
    Nature 364:308-13. 1993
    ..Raf-1 (1-257) binds GTP-Ras in preference to GDP-Ras, and inhibits Ras-GAP activity. Mutations in and around the Ras effector domain impair Ras binding to Raf-1 (1-257) and Ras transforming activity in parallel...
  53. ncbi The S29 ribosomal protein increases tumor suppressor activity of K rev-1 gene on v-K ras-transformed NIH3T3 cells
    N Kondoh
    Department of Cell Genetics, Sasaki Institute, Tokyo, Japan
    Biochim Biophys Acta 1313:41-6. 1996
    ....
  54. ncbi Caenorhabditis elegans LET-502 is related to Rho-binding kinases and human myotonic dystrophy kinase and interacts genetically with a homolog of the regulatory subunit of smooth muscle myosin phosphatase to affect cell shape
    A Wissmann
    University of Calgary, Department of Medical Biochemistry, Alberta, Canada
    Genes Dev 11:409-22. 1997
    ..LET-502 may directly regulate the activity of the MEL-11 containing phosphatase complex and the similarity between LET-502 and DM-kinase suggests a similar function for DM-kinase...
  55. pmc Mitogenic and oncogenic properties of the small G protein Rap1b
    D L Altschuler
    Department of Pharmacology, School of Medicine, University of Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 95:7475-9. 1998
    ..Thus, we propose that the view that holds Rap1 as an antimitogenic protein should be restricted and conclude that Rap1 is a conditional oncoprotein...
  56. pmc Activation of the Lbc Rho exchange factor proto-oncogene by truncation of an extended C terminus that regulates transformation and targeting
    P Sterpetti
    Department of Physiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Mol Cell Biol 19:1334-45. 1999
    ..The human lbc oncogene product is a guanine nucleotide exchange factor that specifically activates the Rho small GTP binding protein, thus resulting in biologically active, GTP-bound Rho, which in turn mediates actin cytoskeletal ..
  57. ncbi Rap1B and Rap2B translocation to the cytoskeleton by von Willebrand factor involves FcgammaII receptor-mediated protein tyrosine phosphorylation
    M Torti
    Department of Biochemistry, University of Pavia, via Bassi 21, 27100 Pavia, Italy
    J Biol Chem 274:13690-7. 1999
    Stimulation of human platelets with von Willebrand factor (vWF) induced the translocation of the small GTPases Rap1B and Rap2B to the cytoskeleton...
  58. ncbi An evaluation of the expression, subcellular localization, and function of rab4 in the exocrine pancreas
    J A Valentijn
    Department of Cell Biology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA
    Biochem Biophys Res Commun 268:847-52. 2000
    ..We propose that the approximately 24-kDa rab4 species is involved in compensatory membrane retrieval following regulated exocytosis, and that rab4-positive endocytic vesicles move through a supranuclear recycling compartment...
  59. ncbi A farnesyltransferase inhibitor attenuates cardiac myocyte hypertrophy and gene expression
    A Calderone
    Universite de Montreal, Departément de Physiologie et Biochimie, et l Institut de Cardiologie de Montréal, Quebec, Canada
    J Mol Cell Cardiol 32:1127-40. 2000
    ..Moreover, these data further suggest alternative ras-independent signaling pathways are also implicated in the hypertrophic response, albeit, there appears to exist a stimulus-specific heterogeneity in their recruitment...
  60. ncbi Analysis of the roles of ICAM-1 in neutrophil transmigration using a reconstituted mammalian cell expression model: implication of ICAM-1 cytoplasmic domain and Rho-dependent signaling pathway
    E Sans
    Laboratoire de Migration Cellulaire et Infiltration Tumorale, Institut Albert Bonniot, Grenoble, France
    J Immunol 166:544-51. 2001
    ....
  61. pmc Mutation of melanosome protein RAB38 in chocolate mice
    Stacie K Loftus
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:4471-6. 2002
    ..of similarities in human gene expression patterns by using microarray analysis reveals that RAB38, a small GTP binding protein, demonstrates a similar expression profile to melanocytic genes...
  62. ncbi Suppression of Rac activity induces apoptosis of human glioma cells but not normal human astrocytes
    Donna L Senger
    Brain Tumor Research Centre, Montreal Neurological Institute, Montreal, Canada H3A 2B4
    Cancer Res 62:2131-40. 2002
    ..Agents that suppress Rac1 activity may therefore be useful therapeutic treatments for malignant gliomas...
  63. ncbi Plant RanGAPs are localized at the nuclear envelope in interphase and associated with microtubules in mitotic cells
    Aniko Pay
    Plant Biology Institute, Biological Research Center, H 6701 Szeged, PO Box 521, Hungary
    Plant J 30:699-709. 2002
    ....
  64. ncbi The small GTP-binding protein Rac1 induces cardiac myocyte hypertrophy through the activation of apoptosis signal-regulating kinase 1 and nuclear factor-kappa B
    Yoshiharu Higuchi
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka 565 087, Japan
    J Biol Chem 278:20770-7. 2003
    ..These findings suggest that Rac1 induces cardiac myocyte hypertrophy mediated through ASK1 and NF-kappaB...
  65. pmc Characterization of the Rac-GAP (Rac-GTPase-activating protein) activity of beta2-chimaerin, a 'non-protein kinase C' phorbol ester receptor
    Maria Jose Caloca
    Center for Experimental Therapeutics and Department of Pharmacology, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104 6160, USA
    Biochem J 375:313-21. 2003
    ..These results strongly emphasize the high complexity of DAG signalling due to the activation of PKC-independent pathways, and cast doubts regarding the selectivity of phorbol esters and DAG analogues as selective PKC activators...
  66. ncbi Rabs, Rips, FIPs, and endocytic membrane traffic
    Rytis Prekeris
    Department of Cellular and Structural Biology, School of Medicine, University of Colorado Health Sciences Center, 4200 E Ninth Ave, Room 4520, B 111, Denver, CO 80262, USA
    ScientificWorldJournal 3:870-80. 2003
    ..Recent studies have identified several Rab11-FIP complex-binding proteins that regulate distinct membrane traffic pathways...
  67. ncbi Integrating three views of Arf1 activation dynamics
    Charles H Robert
    Modélisation et Ingénierie des Protéines, CNRS UMR 8619, Bat 430, Université de Paris Sud 91405 Orsay, France
    J Mol Biol 337:969-83. 2004
    ..Large-scale collective movements in the Arf1-Sec7d complex appear to participate in the insertion of the Sec7d Glu finger into the GDP binding site to promote actual nucleotide release...
  68. ncbi Gem GTPase and tau: morphological changes induced by gem GTPase in cho cells are antagonized by tau
    Fumitaka Oyama
    Department of Neuropathology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 279:27272-7. 2004
    ..Taken together, the present results indicate that the level of Gem GTPase and its cell elongation activity are modulated by tau and suggest that tau may be involved in a Gem GTPase-mediated signal transduction pathway...
  69. ncbi Activation of the small GTPase Rap2B in agonist-stimulated human platelets
    F Greco
    Center of Excellence for Applied Biology, Department of Biochemistry, University of Pavia, Pavia, Italy
    J Thromb Haemost 2:2223-30. 2004
    ..Similarly, a number of other agonists tested, previously known to activate the highly related protein Rap1B, were also able to stimulate Rap2B...
  70. ncbi Neural differentiation of human neuroblastoma GOTO cells via a Rho-Rho kinase-phosphorylation signal transduction and continuous observation of a single GOTO cell during differentiation
    Yoichi Kamata
    Laboratory of Veterinary Public Health, Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Sakai si, Japan
    J Vet Med Sci 69:37-42. 2007
    ..Neurites appeared on the membrane of the cell 2 hr after the treatment and then gradual outgrowth began. These observations are fundamental information in elucidating the mechanism of neural differentiation, especially at an early stage...
  71. ncbi The role of phosphoinositide 3-kinase C2alpha in insulin signaling
    Marco Falasca
    Inositide Signalling Group, Centre for Diabetes and Metabolic Medicine, Institute of Cell and Molecular Science, Barts and The London, Queen Mary s School of Medicine and Dentistry, University of London, London E1 2AT, United Kingdom
    J Biol Chem 282:28226-36. 2007
    ....
  72. ncbi Rho kinase and Ca2+ entry mediate increased pulmonary and systemic vascular resistance in L-NAME-treated rats
    Jasdeep S Dhaliwal
    Dept of Pharmacology, Tulane Univ Health Sciences Center, 1430 Tulane Ave, New Orleans, LA 70112, USA
    Am J Physiol Lung Cell Mol Physiol 293:L1306-13. 2007
    ....
  73. doi Activation of native TRPC3 cation channels by phospholipase D
    Maike D Glitsch
    Department of Physiology, Anatomy, and Genetics, Oxford University, Parks Road, Oxford, UK
    FASEB J 24:318-25. 2010
    ..These results reveal a new mechanism for the gating of the ubiquitous TRPC3 channel and identify a key role for phospholipase D in the generation of the slow excitatory postsynaptic current in cerebellar Purkinje cells...
  74. doi CCM1 regulates vascular-lumen organization by inducing endothelial polarity
    Maria Grazia Lampugnani
    IFOM, FIRC Institute of Molecular Oncology Foundation, 20139 Milan, Italy
    J Cell Sci 123:1073-80. 2010
    ..We propose that VEC, CCM1 and Rap1 form a signaling complex. In the absence of any of these proteins, AJs are dismantled, cell polarity is lost and vascular lumenal structure is severely altered...
  75. pmc Rap1b facilitates NK cell functions via IQGAP1-mediated signalosomes
    Aradhana Awasthi
    Molecular Immunology, Blood Research Institute, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Exp Med 207:1923-38. 2010
    ..Using Rap1a or Rap1b knockout mice, we identify Rap1b as the major isoform in NK cells...
  76. doi Nanoparticles induce platelet activation in vitro through stimulation of canonical signalling pathways
    Gianni F Guidetti
    Department of Biology and Biotechnology, Division of Biochemistry, University of Pavia, Pavia, Italy
    Nanomedicine 8:1329-36. 2012
    ..biochemical pathways involved in canonical platelet activation, such as the stimulation of phospholipase C and Rap1b, resulting in the integrin α(IIb)β3-mediated platelet aggregation, through a mechanism largely dependent on the ..
  77. ncbi Overexpression of OsRab7B3, a small GTP-binding protein gene, enhances leaf senescence in transgenic rice
    Sugunya Pitakrattananukool
    Department of Biology, Faculty of Science, Chiang Mai University, Muang, Chiang Mai, Thailand
    Biosci Biotechnol Biochem 76:1296-302. 2012
    ..Hence it is suggested that OsRab7B3 act as a stress-inducible gene that plays an important role in the leaf senescence process...
  78. doi Rap2A links intestinal cell polarity to brush border formation
    Martijn Gloerich
    Molecular Cancer Research, Centre for Biomedical Genetics and Cancer Genomics Centre, University Medical Center Utrecht, Utrecht 3584 CG, The Netherlands
    Nat Cell Biol 14:793-801. 2012
    ..Thus, epithelial cell polarization is translated directly into the acquisition of brush borders through a small G protein signalling module whose action is positioned by a cortical lipid cue...
  79. pmc An adenosine-mediated signaling pathway suppresses prenylation of the GTPase Rap1B and promotes cell scattering
    Elizabeth Ntantie
    1Department of Pharmacology and Toxicology, Cancer Center, and Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Sci Signal 6:ra39. 2013
    ..We identified a signaling cascade initiated by adenosine A2B receptors that suppressed the prenylation of Rap1B through phosphorylation of Rap1B, which decreased its interaction with the chaperone protein SmgGDS (small GTPase ..
  80. doi Targeting of tonoplast proteins to the vacuole
    Marcela Rojas-Pierce
    Department of Plant Biology, North Carolina State University, Raleigh, NC 27695, United States
    Plant Sci 211:132-6. 2013
    ..With multiple cargo proteins being analyzed under a variety of experimental systems, a clearer picture for targeting mechanisms for tonoplast proteins is starting to emerge. ..
  81. doi Y-39983, a selective Rho-kinase inhibitor, attenuates experimental autoimmune encephalomyelitis via inhibition of demyelination
    Cong Gao
    Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and Ministry of Education of China, Institute of Neuroscience and Second Affiliated Hospital of Guangzhou Medical University, and Department of Neurology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
    Neuroimmunomodulation 20:334-40. 2013
    ..We investigated the protective effect of a specific ROCK inhibitor, Y-39983, on demyelination and axonal damage in chronic EAE...
  82. pmc Sporadic cerebral cavernous malformations: report of further mutations of CCM genes in 40 Italian patients
    Rosalia D'Angelo
    Department of Biomedical Sciences and Morphological and Functional Images, Division of Medical Biotechnologies and Preventive Medicine, University of Messina, Via C Valeria 1, 98125 Messina, Italy IRCCS Centro Neurolesi Bonino Pulejo, via Palermo SS 113, contrada Casazza, 98122 Messina, Italy
    Biomed Res Int 2013:459253. 2013
    ....
  83. pmc ARF1 regulates the Rho/MLC pathway to control EGF-dependent breast cancer cell invasion
    Sabrina Schlienger
    Department of Pharmacology and Membrane Protein Research Group GEPROM, Faculty of Medicine, Universite de Montreal, Montreal, QC H3C 3J7, Canada
    Mol Biol Cell 25:17-29. 2014
    ..Together our findings underscore for the first time a key role for ARF1 in invasion of breast cancer cells and suggest that targeting the ARF/Rho/MLC signaling axis might be a promising strategy to inhibit invasiveness and metastasis. ..
  84. doi Rho Kinase and Dopaminergic Degeneration: A Promising Therapeutic Target for Parkinson's Disease
    Jose L Labandeira-Garcia
    Laboratory of Neuroanatomy and Experimental Neurology, Department of Morphological Sciences, CIMUS, University of Santiago de Compostela, Santiago de Compostela, Spain Networking Research Center on Neurodegenerative Diseases CIBERNED, Spain
    Neuroscientist 21:616-29. 2015
    ..However, it is necessary to develop more potent and selective ROCK inhibitors to reduce side effects and enhance the efficacy. ..
  85. pmc Molecular characterization and identification of target protein of an important vesicle trafficking gene AlRab7 from a salt excreting halophyte Aeluropus lagopoides
    Navya Rajan
    1 Discipline of Wasteland Research, CSIR Central Salt and Marine Chemicals Research Institute, Bhavnagar, India
    DNA Cell Biol 34:83-91. 2015
    ..A novel Rab7 interacting partner AlRabring7 was identified by yeast two-hybrid screening. ..
  86. pmc Retinal pigment epithelial cell expression of active Rap 1a by scAAV2 inhibits choroidal neovascularization
    Haibo Wang
    The John Moran Eye Center, University of Utah, Salt Lake City, Utah, USA
    Mol Ther Methods Clin Dev 3:16056. 2016
    ..virus 2 (scAAV2) with RPE65-promoter-driven GFP vectors were generated and introduced subretinally into Rap1b-deficient mice...
  87. ncbi Extracellular signal-regulated kinase and the small GTP-binding protein, Rac, contribute to the effects of transforming growth factor-beta1 on gene expression
    I Mucsi
    Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto M5G 1X8, Canada
    J Biol Chem 271:16567-72. 1996
    ..7-fold following exposure of NIH 3T3 cells to TGF-beta1 for 3 min. These findings indicate that TGF-beta1 modulates gene expression partly through ERK and Rac in NIH 3T3 cells...
  88. ncbi The small GTP-binding protein RacG regulates uroid formation in the protozoan parasite Entamoeba histolytica
    N Guillen
    Unite de Pathogenie Microbienne Moleculaire, Institut National de la Santé et de la Recherche Médicale U389 Institut Pasteur, France
    J Cell Sci 111:1729-39. 1998
    ..In addition, the number and localization of uroids were modified. These results suggest a role for EhRacG in amoebic morphogenesis and cytokinesis...
  89. doi Ibuprofen improves functional outcome after axotomy and immediate repair in the peripheral nervous system
    Tomas Madura
    Blond McIndoe Research Laboratories, The University of Manchester, Manchester Academic Health Science Centre, and Department of Plastic Surgery, University Hospital of South Manchester, Wythenshawe, Manchester, United Kingdom
    J Plast Reconstr Aesthet Surg 64:1641-6. 2011
    ..In this study we tested the hypothesis, that inhibiting Rho activity by ibuprofen will enhance posttraumatic regeneration after peripheral nerve injury...
  90. pmc Optimized amplification and single-cell analysis identify GnRH-mediated activation of Rap1b in primary rat gonadotropes
    Tony Yuen
    Center for Translational Systems Biology and Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, United States
    Mol Cell Endocrinol 350:10-9. 2012
    ..Real-time PCR confirmed regulation of several transcripts including fosB, c-fos, egr-2 and rap1b, a small GTPase and member of the Ras family...
  91. pmc Prostaglandin E2 reduces the release and infectivity of new cell-free virions and cell-to-cell HIV-1 transfer
    Maria Isabel Clemente
    Laboratorio Inmunobiología Molecular, Hospital General Universitario Gregorio Maranon, Madrid, Spain Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain Networking Research Center on Bioengineering, Biomaterials and Nanomedicine CIBER BBN, Zaragoza, Spain
    PLoS ONE 9:e85230. 2014
    ....
  92. doi Antroquinonol blocks Ras and Rho signaling via the inhibition of protein isoprenyltransferase activity in cancer cells
    Ching Liang Ho
    Division of Hematology Oncology, Department of Internal Medicine, Tri Service General Hospital, Neihu, 114, Taipei, Taiwan, ROC
    Biomed Pharmacother 68:1007-14. 2014
    ....
  93. pmc Failure of insulin-regulated recruitment of the glucose transporter GLUT4 in cardiac muscle of obese Zucker rats is associated with alterations of small-molecular-mass GTP-binding proteins
    I Uphues
    Laboratory of Molecular Cardiology, Diabetes Research Institute, Dusseldorf, Germany
    Biochem J 311:161-6. 1995
    ..We show here an association of the latter defect with alterations at the level of small GTP-binding proteins possibly leading to an impaired trafficking of GLUT4 in the insulin-resistant state...
  94. ncbi Localization of Rabphilin-3A on the synaptic vesicle
    A Mizoguchi
    Department of Anatomy, Kobe University School of Medicine, Japan
    Biochem Biophys Res Commun 202:1235-43. 1994
    ..These results indicate that Rabphilin-3A is localized on the synaptic vesicle in the presynapse...
  95. ncbi Purification of a novel ras GTPase-activating protein from rat brain
    M Maekawa
    Division of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    J Biol Chem 268:22948-52. 1993
    ..The activation of GTPase was observed with normal ras p21 but not with oncogenic ras p21, Rap1B/smg21B, or Ram25K...
  96. ncbi Differential effects of insulin and exercise on Rab4 distribution in rat skeletal muscle
    L A Sherman
    Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02215, USA
    Endocrinology 137:266-73. 1996
    ..The purpose of this study was to determine if Rab4, a small GTP binding protein that has been implicated in the insulin-stimulated translocation of GLUT4 in adipose cells, is involved ..
  97. pmc Involvement of Rabphilin-3A in cortical granule exocytosis in mouse eggs
    N Masumoto
    Department of Obstetrics and Gynecology, Osaka University Medical School, Japan
    J Cell Biol 135:1741-7. 1996
    ..These results show that Rabphilin-3A is involved in Ca(2+)-dependent CG exocytosis at fertilization in mouse eggs...
  98. ncbi Molecular cloning and characterization of rab27a and rab27b, novel human rab proteins shared by melanocytes and platelets
    D Chen
    Section on Human Biochemical Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biochem Mol Med 60:27-37. 1997
    ....
  99. ncbi Molecular characterization of a rab-related small GTP binding protein cDNA from rice (Oryza sativa L. IR-36)
    H Y Kim
    Plant Molecular Biology and Biotechnology Research Center, Gyeongsang National University, Chinju, Korea
    Mol Cells 7:226-30. 1997
    ..roles of plant small GTP binding proteins, we isolated a cDNA clone (ORrab2) encoding the rab-related small GTP binding protein from rice (Oryza sativa L. IR-36) by using human cDNA rab2 as a probe...
  100. pmc Mas oncogene signaling and transformation require the small GTP-binding protein Rac
    I E Zohn
    Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill 27599 7038, USA
    Mol Cell Biol 18:1225-35. 1998
    ..Thus, Rho family proteins are common mediators of transformation by a diverse variety of oncogene proteins that include Ras, Dbl family, and G-protein-coupled oncogene proteins...
  101. pmc Rho1p-Bni1p-Spa2p interactions: implication in localization of Bni1p at the bud site and regulation of the actin cytoskeleton in Saccharomyces cerevisiae
    T Fujiwara
    Department of Molecular Biology and Biochemistry, Osaka University Medical School, Suita 565 0871, Japan
    Mol Biol Cell 9:1221-33. 1998
    ..These results indicate that both Rho1p and Spa2p are involved in the localization of Bni1p at the growth sites where Rho1p regulates reorganization of the actin cytoskeleton through Bni1p...

Research Grants49

  1. Regulation of Neuronal Survival by the Rit GTPase
    DOUGLAS ALLEN ANDRES; Fiscal Year: 2012
    ..Thus, the goal of this research is to speed progress toward therapeutic exploitation of this protein in neurodegenerative disease. ..
  2. JAMES RICHARD GOLDENRING; Fiscal Year: 2016
    ..In intestinal cells, we also have demonstrated that loss of Rab25, an epithelial-specific small GTP binding protein, in Rab25 KO mice promotes intestinal and colonic neoplasia and knockdown of Rab25 expression in CaCo-2 ..
  3. Inorganic phosphate regulated proliferation, transformation and tumorigenesis
    George R Beck; Fiscal Year: 2013
    ..test the hypothesis that phosphate transport in combination with FGF receptor activation regulates the small GTP binding protein, N-ras and subsequent AP-1 transcriptional activation necessary for the phosphate-induced proliferation ..
  4. The Role of FKBP38 in tumorigenesis associated with Tsc deficiency
    Yu Jiang; Fiscal Year: 2012
    ..of TSC1 and TSC2, hamartin and tuberin, form a complex that negatively regulates Rheb, a Ras-like small GTP binding protein. It has been recently found that mTOR, the target of rapamycin, is a major effector of Rheb...
  5. MARIA IRENE KONTARIDIS; Fiscal Year: 2014
    ..RhoA is a small GTP binding protein involved in important cellular functions including cell proliferation, migration and cytoskeletal ..
  6. Ras and Phosphoinositide 3-kinase Signaling in Lens Development
    Lixing W Reneker; Fiscal Year: 2012
    ..This knowledge will help to develop new methods to prevent and treat posterior capsular opacification (PCO), the most common complication of cataract surgery. ..
  7. Sympathetic Control in Heart Failure: A Role of Statins
    Irving H Zucker; Fiscal Year: 2010
    ..The role of the small GTP binding protein Rho and Rho Kinase and NO synthase will be investigated in intact animals and in isolated neuronal cell ..
  8. Magdalena Chrzanowska; Fiscal Year: 2016
    ..Basal and VEGF-induced vascular permeability in two EC-specific Rap1a and Rap1b-KO mice models will be examined...
  9. Novel Insulin Signals Regulating GLUT4 Translocation
    Jeffrey Pessin; Fiscal Year: 2005
    ..Recently, we have determined that a novel small GTP binding protein in the Rho family (TC1O) provides essential function for the insulin-stimulated translocation of GLUT4 ..
  10. Determining the rap1b signaling pathway to integrin activation in platelets
    LUIS ALBERTO PANIAGUA; Fiscal Year: 2012
    ..This integrated approach will help us better understand how mast cells and nTreg cells interact and has the potential to establish a new paradigm for immune regulation, thus opening new insights into immune disease. ..
  11. Role of Carboxyterminal Hypervariable Region in Rap1b Function
    Gilbert C White; Fiscal Year: 2010
    b>Rap1b is a ubiquitous, membrane associated low molecular weight GTPase that has been shown to be important for integrin-mediated platelet aggregation and adhesion...
  12. Rap 1b as a mitogenic signal in thyroid
    Daniel L Altschuler; Fiscal Year: 2012
    ..Agonists that increase intracellular cAMP are able to rapidly phosphorylate and activate Rap1b, and we have recently shown that the Rap-GEF Epac, in synergy with PKA, is required for TSH-dependent mitogenesis...
  13. CAROL LUCILLE WILLIAMS; Fiscal Year: 2014
    ..different forms of SmgGDS promote post-translational processing of the small GTPases K-Ras, Rac1, RhoA, Rap1A, and Rap1B. This model will be tested in the following aims...
  14. RACE PATHWAY IN THE REGULATION OF CYTOKINESIS
    Denis Larochelle; Fiscal Year: 1999
    ..The identification of the proteins required for cytokinesis, and how they interact with one another, will greatly increase our understanding of how this process is regulated in cells. ..
  15. SMOOTH MUSCLE MIGRATION AFTER VASCULAR RECONSTRUCTION
    K Kent; Fiscal Year: 2000
    ....
  16. CHARACTERIZATION OF A NOVEL G PROTEIN IN PLATELETS
    Lawrence Brass; Fiscal Year: 2005
    ..Gi family members in platelets are needed for maximal activation of the low molecular weight GTP-binding protein, Rap1B, and obtained data implicating Rap1B in platelet aggregation...
  17. Attenuation of mucous cell metaplasia by Rad
    Mary Chang; Fiscal Year: 2006
    ..profile study of retinoic acid-induced airway epithelial cell differentiation, we have discovered that a small GTP binding protein, Rad, plays an important role in the attenuation of mucin gene expression mad secretion...
  18. INTESTINE IN CHRONIC PORTAL HYPERTENSION
    JOSEPH BENOIT; Fiscal Year: 2004
    ..Second, failure of the small GTP binding protein Rho A to activate in response to GI and Gq coupled vasoconstrictor is suggested, as this event would ..
  19. cAMP modulation of bile induced hepatocyte apoptosis
    CYNTHIA LEVEILLE WEBSTER; Fiscal Year: 2009
    ..involving activation of cAMP dependent guanine exchange: factor (cAMP-GEF) which signals through the small GTP binding protein Rap...
  20. Mechanism of vascular alpha2C-adrenoceptor mobilization
    Maqsood Chotani; Fiscal Year: 2009
    ..The role of this signaling pathway in phosphorylating the conserved filamin-2 serine2113 will be examined, and the potential relevance to receptor mobilization at 370C and 280C. ..
  21. CONTROL OF SIGMA B ACTIVITY IN B SUBTILIS
    William Haldenwang; Fiscal Year: 2005
    ..that activates sigma B is unknown; however, recent evidence implicates the bacterium's ribosome and a small GTP binding protein (Obg) in this process...
  22. SIGNALS FOR RPE SURVIVAL IN VITRO
    DENNIS DEFOE; Fiscal Year: 1999
    ..By defining specific molecules as targets for promoting or inhibiting cell survival or death, information gained from these studies may form the basis for designing therapeutic strategies to intervene in RPE proliferation and atrophy. ..
  23. Corneal Innervation and Epithelial Cell Migration
    JES KLARLUND; Fiscal Year: 2007
    ..GRP1 is an activator for the small GTP binding protein ARF6, which has been shown to regulate extension of lamellipodia and cell movement...
  24. SPATIAL CONTROL OF CELL POLARITY DURING YEAST BUDDING
    Hay Oak Park; Fiscal Year: 2003
    ..These include the Ras-like small GTP binding protein Bud1, the GTPase Activating Protein (GAP) Bud2, and the Guanine nucleotide Exchange Factor (GEF) Bud5...
  25. INTEGRINS AND D3 PHOSPHOINOSITIDES IN CANCER
    Leslie Shaw; Fiscal Year: 2000
    ..The goal is to identify molecular targets for future metastasis related study. ..
  26. STRUCTURE AND FUNCTION OF VASCULAR INTEGRINS
    LESLIE PARISE; Fiscal Year: 2007
    ..The role of the low molecular weight G protein, rap1b, in integrin activation will be examined using a knockout mouse...
  27. RAPLB AS AN EFFECTOR OF CAMP MEDIATED MITOGENIC ACTION
    Daniel Altschuler; Fiscal Year: 2001
    ..First, cAMP-elevating agents convert Rap1b into its active GTPbound conformation, providing biochemical evidence that Rap1 is a downstream effector for cAMP...
  28. MOLECULAR ANALYSIS OF EAR DEVELOPMENT
    MARGARET LOMAX; Fiscal Year: 2000
    ..The results of these studies should provide insight into the molecular processes involved in ear development, and determine whether these processes are reactivated during hair cell regeneration. ..
  29. RAB5 AND APP PROCESSING AS RELATED TO AGING
    Joseph Buxbaum; Fiscal Year: 2002
    ....
  30. Fyn and Rap1 in T cell Activation and Immune Response
    Konstantina Alexandropoulos; Fiscal Year: 2004
    ..4) We will examine the CD4+ helper and CD8+ cytotoxic T cell responses in SindeltaC transgenic mice and test whether SindeltaC-mediated activation of Fyn and Rapl correlates with T cell anergy in vivo. ..
  31. High throughput assay for small G protein activation
    JACQUES WEISSMAN; Fiscal Year: 2005
    The small GTP binding protein superfamily (consisting of small, monomeric GTP hydrolyzing proteins or GTPases) regulates diverse cellular processes including gene expression, cellular proliferation, cytoskeletal reorganization, vesicle ..
  32. CROSSTALK BETWEEN CAMP AND RAS IN TSH GROWTH SIGNALING
    Judy Meinkoth; Fiscal Year: 2004
    ..Given the high frequency (ca 100 percent) of thyroid tumors observed at autopsy, identification of growth regulatory circuits targeted by cAMP is an important and exciting area for future investigation. ..
  33. Regulation of actin by Rac and Phosphoinositides
    Christopher Carpenter; Fiscal Year: 2005
    ..We should understand better how cells move and advance the fields of cell biology and signal transduction. ..
  34. Integrin Signaling In Vascular Cells
    Susan Smyth; Fiscal Year: 2009
    ..abstract_text> ..
  35. RAP1A AND RAP1B IN THE DIAGNOSIS AND TMT - ORAL CANCER
    NISHA D SILVA; Fiscal Year: 2004
    ..Additionally, a rap1B, a rap1 isoform, will be assessed as a candidate protein for prognosis prediction, when used as a biomarker for ..
  36. Toll-Like Receptors in Bacterial Antigen Induced HIV-LTR
    Ozlem Equils; Fiscal Year: 2004
    ..abstract_text> ..
  37. Diabetes, Inflammation and Vascular Disease
    Susan Smyth; Fiscal Year: 2004
    ..Moreover, our results may have broad implications for the treatment and prevent of accelerated atherosclerosis and thrombosis in diabetes. ..
  38. Regulation of Superoxide Production by the Macula Densa during TGF
    Ruisheng Liu; Fiscal Year: 2010
    ..We believe the results of the present study will help us better understand the causes of hypertension and might reveal new approaches for treatment. ..
  39. SIGNALING PATHWAYS OF ARF GTPASES AND ARF GAPS
    Richard Premont; Fiscal Year: 2005
    ..abstract_text> ..
  40. Activation of eNOS by Steroid Hormones
    James Liao; Fiscal Year: 2006
    ....
  41. Role of Prostaglandins & Phospholipase A in melanocytes
    Glynis Scott; Fiscal Year: 2009
    ..We hypothesize that PG and phospholipases stimulate HM dendricity, MS transfer &pigmentation through different mechanisms that act synergistically to modulate cutaneous pigmentation following UVR. ..
  42. TRANSCRIPTION FACTOR NF-E2 IN ALPHA IIB BETA 3 SIGNALING
    SANFORD SHATTIL; Fiscal Year: 2004
    ..abstract_text> ..
  43. Endothelial Akt in Vascular Injury
    James Liao; Fiscal Year: 2009
    ..Three specific aims are proposed, which will study the role of endothelial Akt in models of vascular injury and atherosclerosis. ..
  44. Dopamine Receptor Regulation by GRKs in Drug Abuse
    Richard Premont; Fiscal Year: 2008
    ..The results of these studies will define the role of GRK6 in setting the basal tone of dopamine signaling in the striatum. [unreadable] [unreadable] [unreadable]..
  45. Platelet Membrane Proteins in Thrombosis
    Susan Smyth; Fiscal Year: 2005
    ..This work will identify a novel target for future antithrombotic strategies and challenge the assumption that the beneficial effects of P-selectin antagonists are exclusive to leukocytes. ..
  46. Regulation of Outside-In Integrin Signaling in Platelets
    SANFORD SHATTIL; Fiscal Year: 2007
    ..Thus, this line of investigation may lead to identification of new anti-thrombotic drug targets and serve as a paradigm for integrin signaling in other blood cells. [unreadable] [unreadable] [unreadable]..
  47. Role of PI3-Kinase in Estrogen-induced eNOS Activation
    James Liao; Fiscal Year: 2007
    ..These results may explain some of the actions of selective estrogen receptor modulators (SERMs) and provide a therapeutic basis for using estrogens in cardiovascular disease. ..
  48. A Universal Mouse Line to Assess Tumor Clonality
    Daniel Altschuler; Fiscal Year: 2006
    ..Therefore, we consider this line will be of interest to other NIH institutes (e.g. NIDDK, NIEHS, NCI) and that will contribute significantly to many areas of research. ..
  49. Rap 1-Mediated Protein Transport in Oral Cancer
    NISHA D SILVA; Fiscal Year: 2006
    ..uncharacterized but an exciting and significant area of research is the signaling cascade triggered by rap1A and rap1B, ras-like proteins that have been shown to have oncogenic and/or tumor suppressive properties in mesenchymal cells...

Patents1

  1. NOVEL PROTEINS, DNA CODING FOR SAID PROTEINS, AND THEIR USE
    Patent Number: WO9000179-A2; Date:1990-01-11