RANGAP1

Summary

Gene Symbol: RANGAP1
Description: Ran GTPase activating protein 1
Alias: Fug1, RANGAP, ran GTPase-activating protein 1, segregation distorter homolog, segregation distortion
Species: human

Top Publications

  1. ncbi Distinct and overlapping sets of SUMO-1 and SUMO-2 target proteins revealed by quantitative proteomics
    Alfred C O Vertegaal
    Department of Molecular Cell Biology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Mol Cell Proteomics 5:2298-310. 2006
  2. pmc Determinants of small ubiquitin-like modifier 1 (SUMO1) protein specificity, E3 ligase, and SUMO-RanGAP1 binding activities of nucleoporin RanBP2
    Jaclyn R Gareau
    Structural Biology Program, Sloan Kettering Institute, New York, New York 10065, USA
    J Biol Chem 287:4740-51. 2012
  3. ncbi Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation
    Michael H Tatham
    Center for Biomolecular Sciences, University of St Andrews, St Andrews, Scotland
    Biochemistry 42:9959-69. 2003
  4. ncbi In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2
    T Okuma
    School of Life Science, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo, 192 0392, Japan
    Biochem Biophys Res Commun 254:693-8. 1999
  5. ncbi SUMO-1 protease-1 regulates gene transcription through PML
    Jennifer L Best
    Division of Hematology Oncology, Children s Hospital, Department of Medicine, Boston, MA 02115, USA
    Mol Cell 10:843-55. 2002
  6. ncbi TOPORS functions as a SUMO-1 E3 ligase for chromatin-modifying proteins
    Pooja Pungaliya
    Department of Pharmacology, The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 195 Little Albany Street, New Brunswick, New Jersey 08901, USA
    J Proteome Res 6:3918-23. 2007
  7. ncbi RNA1 encodes a GTPase-activating protein specific for Gsp1p, the Ran/TC4 homologue of Saccharomyces cerevisiae
    J Becker
    Max Planck Institut fur molekulare Physiologie, Abteilung Strukturelle Biologie, Dortmund, Germany
    J Biol Chem 270:11860-5. 1995
  8. pmc Co-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBP1
    F R Bischoff
    Division for Molecular Biology of Mitosis, German Cancer Research Center, Heidelberg
    EMBO J 14:705-15. 1995
  9. pmc RanGAP1 induces GTPase activity of nuclear Ras-related Ran
    F R Bischoff
    Division for Molecular Biology of Mitosis, German Cancer Research Center, Heidelberg, Federal Republic of Germany
    Proc Natl Acad Sci U S A 91:2587-91. 1994
  10. pmc A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex
    M J Matunis
    Laboratory of Cell Biology, Howard Hughes Medical Institute, Rockefeller University, New York, NY 10021, USA
    J Cell Biol 135:1457-70. 1996

Research Grants

  1. Thomas M Aune; Fiscal Year: 2014
  2. ESTHER BETRAN; Fiscal Year: 2014
  3. GENETICS OF INSULIN-DEPENDENT DIABETES MELLITUS
    CHESTER ALPER; Fiscal Year: 1991
  4. MATTHEW SIMON COOK; Fiscal Year: 2014
  5. The Genetics of Parallel Reproductive Isolation in Stickleback Species Pairs
    Catherine L Peichel; Fiscal Year: 2012
  6. MOLECULAR AND EVOLUTIONARY GENETICS OF SEGREGATION
    CHUNG WU; Fiscal Year: 1992
  7. INFLUENCE OF SEX AND HLA ON RHEUMATOID ARTHRITIS
    George Moxley; Fiscal Year: 2003
  8. MUTATION IN HYBRIDS OF DROSOPHILA
    Michael Simmons; Fiscal Year: 2000
  9. FUNCTIONAL ANALYSIS OF THE T COMPLEX
    John Schimenti; Fiscal Year: 2006
  10. METHODS FOR HUMAN GENETIC LINKAGE MAPPING
    Mary Sara McPeek; Fiscal Year: 2001

Detail Information

Publications182 found, 100 shown here

  1. ncbi Distinct and overlapping sets of SUMO-1 and SUMO-2 target proteins revealed by quantitative proteomics
    Alfred C O Vertegaal
    Department of Molecular Cell Biology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Mol Cell Proteomics 5:2298-310. 2006
    ....
  2. pmc Determinants of small ubiquitin-like modifier 1 (SUMO1) protein specificity, E3 ligase, and SUMO-RanGAP1 binding activities of nucleoporin RanBP2
    Jaclyn R Gareau
    Structural Biology Program, Sloan Kettering Institute, New York, New York 10065, USA
    J Biol Chem 287:4740-51. 2012
    ..repeat domain (IR1-M-IR2) that catalyzes E3 ligase activity and forms a stable complex with SUMO-modified RanGAP1 and UBC9 at the nuclear pore complex...
  3. ncbi Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation
    Michael H Tatham
    Center for Biomolecular Sciences, University of St Andrews, St Andrews, Scotland
    Biochemistry 42:9959-69. 2003
    ..of Ubc9, and the effect of the amino acid substitutions on binding and conjugation to SUMO-1 and target protein RanGAP1 was investigated by isothermal titration calorimetry and biochemical analysis...
  4. ncbi In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2
    T Okuma
    School of Life Science, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo, 192 0392, Japan
    Biochem Biophys Res Commun 254:693-8. 1999
    The SUMO-1 has been identified as a protein that is highly similar to ubiquitin and shown to conjugate to RanGAP1, PML, Sp200 and I kappa B alpha...
  5. ncbi SUMO-1 protease-1 regulates gene transcription through PML
    Jennifer L Best
    Division of Hematology Oncology, Children s Hospital, Department of Medicine, Boston, MA 02115, USA
    Mol Cell 10:843-55. 2002
    ..SuPr-1 action on transcription was enhanced by PML, and SuPr-1 failed to activate transcription in PML-deficient fibroblasts. Our studies establish an important role for SUMO proteases in transcription...
  6. ncbi TOPORS functions as a SUMO-1 E3 ligase for chromatin-modifying proteins
    Pooja Pungaliya
    Department of Pharmacology, The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 195 Little Albany Street, New Brunswick, New Jersey 08901, USA
    J Proteome Res 6:3918-23. 2007
    ..Transfection studies confirmed mammalian Sin3A as a sumoylation substrate for TOPORS. These findings suggest that TOPORS may function as a tumor suppressor by regulating mSin3A and other proteins involved in chromatin modification...
  7. ncbi RNA1 encodes a GTPase-activating protein specific for Gsp1p, the Ran/TC4 homologue of Saccharomyces cerevisiae
    J Becker
    Max Planck Institut fur molekulare Physiologie, Abteilung Strukturelle Biologie, Dortmund, Germany
    J Biol Chem 270:11860-5. 1995
    ..In addition, we find that the previously identified human RanGAP1 and rna1p from Schizosaccharomyces pombe are also able to induce GTPase activity of Gsp1p...
  8. pmc Co-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBP1
    F R Bischoff
    Division for Molecular Biology of Mitosis, German Cancer Research Center, Heidelberg
    EMBO J 14:705-15. 1995
    ..RanBP1 does not activate RanGTPase, but increases GTP hydrolysis induced by the RanGTPase-activating protein RanGAP1 by an order of magnitude. In the absence of RanGAP, it strongly inhibits RCC1-induced exchange of Ran-bound GTP...
  9. pmc RanGAP1 induces GTPase activity of nuclear Ras-related Ran
    F R Bischoff
    Division for Molecular Biology of Mitosis, German Cancer Research Center, Heidelberg, Federal Republic of Germany
    Proc Natl Acad Sci U S A 91:2587-91. 1994
    ..Here a nuclear homodimeric 65-kDa protein, RanGAP1, is described, which we believe to be the immediate antagonist of RCC1...
  10. pmc A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex
    M J Matunis
    Laboratory of Cell Biology, Howard Hughes Medical Institute, Rockefeller University, New York, NY 10021, USA
    J Cell Biol 135:1457-70. 1996
    ..A key regulator of the Ran GTP/GDP cycle is the 70-kD Ran-GTPase-activating protein RanGAP1. Here, we report the identification and localization of a novel form of RanGAP1...
  11. ncbi A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2
    R Mahajan
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Cell 88:97-107. 1997
    We have found that the mammalian Ran GTPase-activating protein RanGAP1 is highly concentrated at the cytoplasmic periphery of the nuclear pore complex (NPC), where it associates with the 358-kDa Ran-GTP-binding protein RanBP2...
  12. pmc Molecular characterization of the SUMO-1 modification of RanGAP1 and its role in nuclear envelope association
    R Mahajan
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Cell Biol 140:259-70. 1998
    The mammalian guanosine triphosphate (GTP)ase-activating protein RanGAP1 is the first example of a protein covalently linked to the ubiquitin-related protein SUMO-1...
  13. pmc SUMO-1 modification and its role in targeting the Ran GTPase-activating protein, RanGAP1, to the nuclear pore complex
    M J Matunis
    Laboratory of Cell Biology, Howard Hughes Medical Institute, The Rockefeller University, New York 10021, USA
    J Cell Biol 140:499-509. 1998
    b>RanGAP1 is the GTPase-activating protein for Ran, a small ras-like GTPase involved in regulating nucleocytoplasmic transport...
  14. ncbi Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1
    Victor Bernier-Villamor
    Biochemistry Department, Structural Biology Program, Weill Medical College of Cornell University, New York, NY 10021, USA
    Cell 108:345-56. 2002
    ..Crystallographic analysis of a complex between mammalian Ubc9 and a C-terminal domain of RanGAP1 at 2...
  15. pmc SUMO-1 targets RanGAP1 to kinetochores and mitotic spindles
    Jomon Joseph
    Laboratory of Gene Regulation and Development, National Institute of Child Health and Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 156:595-602. 2002
    b>RanGAP1 was the first documented substrate for conjugation with the ubiquitin-like protein SUMO-1. However, the functional significance of this conjugation has not been fully clarified...
  16. pmc Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex
    Hong Zhang
    Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Mol Cell Biol 22:6498-508. 2002
    ..In vitro binding studies revealed that Ubc9 and SUMO-1-modified RanGAP1 bind synergistically to form a trimeric complex with a component of the cytoplasmic filaments of the NPC, Nup358...
  17. ncbi The RanGAP1-RanBP2 complex is essential for microtubule-kinetochore interactions in vivo
    Jomon Joseph
    National Institutes of Health, National Institute of Child Health and Human Development, Building 18, Room 106, 18 Library Drive, MSC 5431, Bethesda, MD 20892, USA
    Curr Biol 14:611-7. 2004
    b>RanGAP1 is the activating protein for the Ran GTPase. Vertebrate RanGAP1 is conjugated to a small ubiquitin-like protein, SUMO-1...
  18. pmc Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complex
    David Reverter
    Structural Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Nature 435:687-92. 2005
    ..In addition to being a SUMO E3, the nucleoporin Nup358/RanBP2 localizes SUMO-conjugated RanGAP1 to the cytoplasmic face of the nuclear pore complex by means of interactions in a complex that also includes Ubc9,..
  19. pmc The structure of SENP1-SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing
    Lin Nan Shen
    Centre for Biomolecular Sciences, University of St Andrews, St Andrews, Scotland KY16 9ST, UK
    Biochem J 397:279-88. 2006
    ....
  20. pmc The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions
    Michela Zuccolo
    Centre de Recherche, UMR 144 CNRS, Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    EMBO J 26:1853-64. 2007
    ..we show that the presence of the Nup107-160 complex at kinetochores is required for the recruitment of Crm1 and RanGAP1-RanBP2 to these structures...
  21. doi Mechanism and consequences for paralog-specific sumoylation of ubiquitin-specific protease 25
    Erik Meulmeester
    Department of Biochemistry I, Faculty of Medicine, Georg August University of Gottingen, Humboldtallee 23, 37073 Gottingen, Germany
    Mol Cell 30:610-9. 2008
    ..One mechanism for paralog-specific sumoylation may, thus, involve SIM-dependent recruitment of SUMO1 or SUMO2/3 thioester-charged Ubc9 to targets...
  22. pmc Protection from isopeptidase-mediated deconjugation regulates paralog-selective sumoylation of RanGAP1
    Shanshan Zhu
    Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Mol Cell 33:570-80. 2009
    ..Despite being equally well modified by SUMO-1 and SUMO-2 in vitro, RanGAP1 is selectively modified by SUMO-1 in vivo...
  23. pmc Structure of the Siz/PIAS SUMO E3 ligase Siz1 and determinants required for SUMO modification of PCNA
    Ali A Yunus
    Sloan Kettering Institute, New York, NY 10065, USA
    Mol Cell 35:669-82. 2009
    ..Mutational analysis of Siz1 and PCNA revealed surfaces on both proteins that are required for efficient SUMO modification of PCNA in vitro and in vivo...
  24. doi The RanBP2/RanGAP1*SUMO1/Ubc9 complex is a multisubunit SUMO E3 ligase
    Andreas Werner
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, DKFZ ZMBH Alliance, Heidelberg, Germany
    Mol Cell 46:287-98. 2012
    ..However, why RanBP2 functions in vivo has been unclear: throughout the cell cycle it stably interacts with RanGAP1*SUMO1 and Ubc9, whose binding sites overlap with the E3 ligase region...
  25. pmc Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport
    F R Bischoff
    Division of Molecular Biology of Mitosis, German Cancer Research Center, Heidelberg
    Proc Natl Acad Sci U S A 92:1749-53. 1995
    b>RanGAP1 is the GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state. Here, we report the amino acid sequence of RanGAP1, derived from cDNA and peptide sequences...
  26. pmc Identification of different roles for RanGDP and RanGTP in nuclear protein import
    D Gorlich
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, Germany
    EMBO J 15:5584-94. 1996
    ..The principal GTP exchange factor for Ran is the nuclear protein RCC1, whereas the major RanGAP is cytoplasmic, predicting that nuclear Ran is mainly in the GTP form and cytoplasmic Ran is in the GDP-bound form...
  27. pmc RanGAP1*SUMO1 is phosphorylated at the onset of mitosis and remains associated with RanBP2 upon NPC disassembly
    Sowmya Swaminathan
    Max Planck Institute for Biochemistry, Am Klopferspitz 18, D 82152 Martinsried, Germany
    J Cell Biol 164:965-71. 2004
    The RanGTPase activating protein RanGAP1 has essential functions in both nucleocytoplasmic transport and mitosis...
  28. pmc The Nup358-RanGAP complex is required for efficient importin alpha/beta-dependent nuclear import
    Saskia Hutten
    Department of Biochemistry I, Faculty of Medicine, Georg August University of Gottingen, 37073, Gottingen, Germany
    Mol Biol Cell 19:2300-10. 2008
    ..Nup358 forms a complex with SUMOylated RanGAP1, the GTPase activating protein for Ran...
  29. doi Regulation of Wnt signaling by the nuclear pore complex
    Miki Shitashige
    Chemotherapy Division and Cancer Proteomics Project, National Cancer Center Research Institute, Tokyo, Japan
    Gastroenterology 134:1961-71, 1971.e1-4. 2008
    ..However, beta-catenin has no nuclear localization signal, and the mechanisms by which beta-catenin is imported into the nucleus and forms a complex with the TCF-4 nuclear protein are poorly understood...
  30. pmc Construction of two genetic linkage maps in cultivated tetraploid alfalfa (Medicago sativa) using microsatellite and AFLP markers
    Bernadette Julier
    INRA, Unité de Génétique et d Amélioration des Plantes Fourragères, 86600 Lusignan, France
    BMC Plant Biol 3:9. 2003
    ..A genetic map was constructed with AFLP and SSR markers using specific mapping procedures for autotetraploids. The tetrasomic inheritance was analysed in an alfalfa mapping population...
  31. ncbi A comparative analysis of the rainbow trout genome with 2 other species of fish (Arctic charr and Atlantic salmon) within the tetraploid derivative Salmonidae family (subfamily: Salmoninae)
    Roy G Danzmann
    Department of Integrative Biology, University of Guelph, ON, Canada
    Genome 48:1037-51. 2005
    ..some possible exceptions were detected and these findings are discussed in relation to their influence on segregation distortion patterns...
  32. ncbi Export of importin alpha from the nucleus is mediated by a specific nuclear transport factor
    U Kutay
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, Federal Republic of Germany
    Cell 90:1061-71. 1997
    ..Importin alpha is released from this complex in the cytoplasm by the combined action of RanBP1 and RanGAP1. CAS binds preferentially to NLS-free importin alpha, explaining why import substrates stay in the nucleus.
  33. pmc Mapping of a quantitative trait locus for resistance against infectious salmon anaemia in Atlantic salmon (Salmo salar): comparing survival analysis with analysis on affected/resistant data
    Thomas Moen
    AKVAFORSK Institute of Aquaculture Research, As, Norway
    BMC Genet 8:53. 2007
    ..e. using time-to-event data), and to compare results using survival analysis with results from analysis on the dichotomous trait 'affected/resistant'...
  34. pmc Ran-binding protein 5 (RanBP5) is related to the nuclear transport factor importin-beta but interacts differently with RanBP1
    R Deane
    Abteilung Molekulare Biologie der Mitose, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Mol Cell Biol 17:5087-96. 1997
    ..Like importin-beta, RanBP5 strongly binds the GTP-bound form of Ran, stabilizing it against both intrinsic and RanGAP1-induced GTP hydrolysis and also against nucleotide exchange...
  35. doi Segregation distortion of wild-type alleles at the Machado-Joseph disease locus: a study in normal families from the Azores islands (Portugal)
    Conceição Bettencourt
    Department of Biology CIRN, University of the Azores, Rua Mãe de Deus, Apartado 1422, 9501 801 Ponta Delgada, Azores, Portugal
    J Hum Genet 53:333-9. 2008
    ..Therefore, the genotypic composition of the transmitters in a sample to be analysed should influence the ability to detect SRD, acting as a confounding factor...
  36. ncbi A genetic linkage map of microsatellite, gene-specific and morphological markers in diploid Fragaria
    D J Sargent
    East Malling Research, New Road, East Malling, West Malling, Kent ME19 6BJ, UK
    Theor Appl Genet 109:1385-91. 2004
    ..b>Segregation distortion was observed at a high proportion of loci (54%), which could reflect the interspecific nature of the ..
  37. ncbi Covalent modification of PML by the sentrin family of ubiquitin-like proteins
    T Kamitani
    Department of Internal Medicine, and Research Center for Cardiovascular Diseases, Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Houston Health Science Center, Houston, Texas 77030, USA
    J Biol Chem 273:3117-20. 1998
    ..Similar specificity is also observed for the covalent modification of RanGAP1 by the sentrin member of ubiquitin-like proteins...
  38. pmc Alignment of genetic and physical maps of Gibberella zeae
    Jungkwan Lee
    USDA ARS Plant Science and Entomology Research Unit, Throckmorton Plant Sciences Center, Kansas State University, Manhattan, KS 66506 5502, USA
    Appl Environ Microbiol 74:2349-59. 2008
    ..Two of four regions with segregation distortion were explained by the two selectable markers employed in making the cross...
  39. ncbi Differential regulation of sentrinized proteins by a novel sentrin-specific protease
    L Gong
    Research Center for Cardiovascular Diseases, Institute of Molecular Medicine for the Prevention of Human Diseases, Division of Molecular Medicine, The University of Texas Houston Health Science, Houston, USA
    J Biol Chem 275:3355-9. 2000
    ..a tumor suppressor protein that resides in the nucleus, was selectively affected by SENP1, whereas sentrinized RanGAP1, which is associated with the cytoplasmic fibrils of the nuclear pore complex, remained intact...
  40. pmc Genomic linkage map of the human blood fluke Schistosoma mansoni
    Charles D Criscione
    Department of Biology, Texas A and M University, College Station, TX 77843, USA
    Genome Biol 10:R71. 2009
    ..mansoni's molecular, quantitative, and population genetics. Our goal was to construct a genetic linkage map for S. mansoni, and thus provide a new resource that will help stimulate research on this neglected pathogen...
  41. pmc WPP-domain proteins mimic the activity of the HSC70-1 chaperone in preventing mistargeting of RanGAP1-anchoring protein WIT1
    Jelena Brkljacic
    Department of Plant Cellular and Molecular Biology, Plant Biotechnology Center, The Ohio State University, Columbus, Ohio 43210, USA
    Plant Physiol 151:142-54. 2009
    ..They have sequence similarity to the nuclear envelope-targeting domain of plant RanGAP1, the GTPase activating protein of the small GTPase Ran...
  42. ncbi Anchorage of plant RanGAP to the nuclear envelope involves novel nuclear-pore-associated proteins
    Xianfeng Morgan Xu
    Plant Biotechnology Center and Department of Plant Cellular and Molecular Biology, The Ohio State University, Columbus, OH 43210, USA
    Curr Biol 17:1157-63. 2007
    ..Mammalian RanGAP1 targeting to the NE and kinetochores requires interaction of its sumoylated C-terminal domain with the ..
  43. doi High genetic differentiation between an African and a non-African strain of Drosophila simulans revealed by segregation distortion and reduced crossover frequency
    Haruki Tatsuta
    Department of Population Genetics, National Institute of Genetics, Mishima, Shizuoka 411 8540, Japan
    Genetica 137:165-71. 2009
    ..melanogaster. Here, we report a strong segregation distortion in the F1 intercross between two D...
  44. pmc Negative segregation distortion in the SD system of Drosophila melanogaster: a challenge to the concept of differential sensitivity of Rsp alleles
    Y Hiraizumi
    Department of Zoology, University of Texas, Austin 78712
    Genetics 125:515-25. 1990
    Current models of segregation distortion based on previous experimental results predict that, in the Sd heterozygous Rspi/Rsps male, the chromosome carrying the sensitive Rsps allele is distorted or transmitted in a frequency smaller than ..
  45. doi Analysis of segregation distortion and association of the bovine FGF2 with fertilization rate and early embryonic survival
    X Wang
    College of Animal Science and Technology, Northwest A and F University, Yangling, Shaanxi 712100, China
    Anim Genet 40:722-8. 2009
    ..A significant segregation distortion was observed for 169 embryos genotyped for the g.23G>T SNP...
  46. doi Construction of a high-density composite map and comparative mapping of segregation distortion regions in barley
    Haobing Li
    Tasmanian Institute of Agricultural Research and School of Agricultural Science, University of Tasmania, Private Bag 54, Hobart, TAS, 7001, Australia
    Mol Genet Genomics 284:319-31. 2010
    b>Segregation distortion can negatively impact on gains expected using selection...
  47. ncbi Evolution at the mouse t complex: why is the t haplotype preserved as an integral unit?
    M van Boven
    Institute for Animal Science and Health, Lelystad, The Netherlands
    Evolution 54:1795-808. 2000
    ..All well-known segregation distortion systems consist of one or more "distorter" loci that act upon a "responder" locus...
  48. pmc Sexual conflict and the alternation of haploid and diploid generations
    David Haig
    Department of Organismic and Evolutionary Biology, Harvard University, 26 Oxford Street, Cambridge, MA 02138, USA
    Philos Trans R Soc Lond B Biol Sci 361:335-43. 2006
    ..Therefore, sexual conflict is predicted to be attenuated. Finally, we explore similarities among models of mate choice, offspring choice and segregation distortion.
  49. pmc Genetic basis for dosage sensitivity in Arabidopsis thaliana
    Isabelle M Henry
    Department of Biology, University of Washington, Seattle, Washington, United States of America
    PLoS Genet 3:e70. 2007
    ..recombinant inbred lines, a single locus, which we call SENSITIVE TO DOSAGE IMBALANCE (SDI), exhibited segregation distortion in the tetraploid subpopulation only...
  50. doi Precision of distances and ordering of microsatellite markers in consensus linkage maps of chromosomes 1, 3 and 4 from two reciprocal chicken populations using bootstrap sampling
    M F Rosário
    Departamento de Genetica, Escola Superior de Agricultura Luiz de Queiroz, Universidade de Sao Paulo, Piracicaba, SP, Brasil
    Genet Mol Res 9:1357-76. 2010
    ..Some loci showed segregation distortion and missing data, but this did not affect the analyses negatively...
  51. doi Segregation distortion and linkage analysis in eggplant (Solanum melongena L.)
    Lorenzo Barchi
    University of Turin, Department of Exploitation and Protection of the Agricultural and Forestry Resources DiVaPRA, Plant Genetics and Breeding, Via Grugliasco TO, Italy
    Genome 53:805-15. 2010
    ..as well as markers closely linked to Rfo-sa1 was substantially distorted, while in the F2 population, segregation distortion was restricted to just 10 markers, and thus the latter was chosen for map development...
  52. ncbi Molecular analysis of the responder satellite DNA in Drosophila melanogaster: DNA bending, nucleosome structure, and Rsp-binding proteins
    P Doshi
    Department of Biology, University of Rochester
    Mol Biol Evol 8:721-41. 1991
    The Responder (Rsp) locus of Drosophila melanogaster, the target locus of segregation distortion, is a satellite DNA array. This repeat array imparts some fitness advantage to the chromosomes bearing it...
  53. ncbi Common features of segregation distortion in plants and animals
    Douglas R Taylor
    Department of Biology, Box 400328, University of Virginia, Charlottesville, VA 22904 4328, USA
    Genetica 117:27-35. 2003
    b>Segregation distortion is increasingly recognized as a potentially powerful evolutionary force...
  54. pmc An AFLP-based genetic linkage map of channel catfish (Ictalurus punctatus) constructed by using an interspecific hybrid resource family
    Zhanjiang Liu
    The Fish Molecular Genetics and Biotechnology Laboratory, Department of Fisheries and Allied Aquacultures Program of Cell and Molecular Biosciences, Auburn University, Auburn, Alabama 36849, USA
    Genetics 165:687-94. 2003
    ..Among the remaining 189 markers, 101 were not used because of significant segregation distortion, 29 were unlinked, and 59 were eliminated because they span very large distances...
  55. ncbi Genetic segregation of microsatellite markers in Saccharum officinarum and S. spontaneum
    S J Edmé
    USDA ARS Sugarcane Field Station, 12990 US Hwy 441 N, Canal Point, FL 33438, USA
    Heredity (Edinb) 97:366-75. 2006
    ..A specific chromosome associated with segregation distortion was detected in the female (GG) genome only, probably as a result of double reduction...
  56. pmc Localized RanGTP accumulation promotes microtubule nucleation at kinetochores in somatic mammalian cells
    Liliana Torosantucci
    IBPM Institute of Molecular Biology and Pathology, National Research Council, c o University of Rome La Sapienza, 00185 Rome, Italy
    Mol Biol Cell 19:1873-82. 2008
    ..requires local RanGTP accumulation concomitant with delocalization from kinetochores of the hydrolysis factor RanGAP1. Kinetochore-driven microtubule nucleation is also activated after cold-induced microtubule disassembly when ..
  57. pmc A SSR-based composite genetic linkage map for the cultivated peanut (Arachis hypogaea L.) genome
    Yanbin Hong
    Guangdong Academy of Agricultural Sciences, Crops Research Institute, Guangzhou, PR China
    BMC Plant Biol 10:17. 2010
    ....
  58. pmc Genome mapping of white clover (Trifolium repens L.) and comparative analysis within the Trifolieae using cross-species SSR markers
    Yan Zhang
    Forage Improvement Division, The Samuel Roberts Noble Foundation, 2510, Sam Noble Parkway, Ardmore, OK 73401, USA
    Theor Appl Genet 114:1367-78. 2007
    ..Map density was approximately 5 cM per locus. Segregation distortion was detected in six segments of the genome (homoeologous groups A1, A2, B1, B2, C1, and D1)...
  59. ncbi The genetic architecture of ecological speciation and the association with signatures of selection in natural lake whitefish (Coregonus sp. Salmonidae) species pairs
    S M Rogers
    Québec Océan, Departement de Biologie, Universite Laval, Ste Foy, Quebec, Canada
    Mol Biol Evol 24:1423-38. 2007
    ..Two parallel QTL outliers for growth and condition factor exhibited segregation distortion in both mapping families, supporting the hypothesis that adaptive divergence contributing to parallel ..
  60. doi Development of molecular markers and linkage maps for the Carthamus species C. tinctorius and C. oxyacanthus
    Reinhold Mayerhofer
    Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada
    Genome 53:266-76. 2010
    ..Noticeable segregation distortion was found on one linkage group of the C...
  61. pmc Recent approaches into the genetic basis of inbreeding depression in plants
    David E Carr
    Blandy Experimental Farm, University of Virginia, 400 Blandy Farm Lane, Boyce, VA 22620, USA
    Philos Trans R Soc Lond B Biol Sci 358:1071-84. 2003
    ..Studies of marker segregation distortion commonly uncover genes of major effect on viability, but these have only minor contributions to inbreeding ..
  62. ncbi Familial mycosis fungoides: report of 6 kindreds and a study of the HLA system
    Emmilia Hodak
    Department of Dermatology, Sackler Faculty of Medicine, Tel Aviv University, Petah Tiqva, Israel
    J Am Acad Dermatol 52:393-402. 2005
    ..Recently, the HLA class II alleles DRB1* 11 and DQB1* 03 have been found to be significantly increased for patients with sporadic MF, suggesting a possible immunogenetic basis for the pathogenesis of this malignancy...
  63. ncbi An expressed sequence tag SSR map of tetraploid alfalfa (Medicago sativa L.)
    M K Sledge
    The Samuel Roberts Noble Foundation, Ardmore, 73402 OK, USA
    Theor Appl Genet 111:980-92. 2005
    ..5 to 4.4 cM, and an overall average density of 2.2 cM. Segregation distortion was 10%, and distorted loci tended to cluster on individual homologues of several linkage groups.
  64. ncbi Simple sequence repeat marker development and genetic mapping in quinoa (Chenopodium quinoa Willd.)
    D E Jarvis
    Brigham Young University, Department of Plant and Animal Sciences, Provo, UT 84602, USA
    J Genet 87:39-51. 2008
    ..The map consists of 38 linkage groups (LGs) covering 913 cM. Segregation distortion was observed in the mapping population for several marker loci, indicating possible chromosomal regions ..
  65. pmc Selection at work in self-incompatible Arabidopsis lyrata. II. Spatial distribution of S haplotypes in Iceland
    Mikkel H Schierup
    Department of Ecology and Genetics, Institute of Biology, University of Aarhus, 8000 Aarhus C, Denmark
    Genetics 180:1051-9. 2008
    ..Frequencies in nature reflect effects of segregation distortion previously observed in controlled crosses...
  66. doi Virtual breakdown of the nuclear envelope in fission yeast meiosis
    Haruhiko Asakawa
    Graduate School of Frontier Biosciences, Osaka University, Suita 565 0871, Japan
    Curr Biol 20:1919-25. 2010
    Asymmetric localization of Ran regulators (RanGAP1 and RanGEF/RCC1) produces a gradient of RanGTP across the nuclear envelope. In higher eukaryotes, the nuclear envelope breaks down as the cell enters mitosis (designated "open" mitosis)...
  67. pmc Quantitative trait locus mapping can benefit from segregation distortion
    Shizhong Xu
    Department of Botany and Plant Sciences, University of California, Riverside, California 92521, USA
    Genetics 180:2201-8. 2008
    b>Segregation distortion is a phenomenon that has been observed in many experimental systems. How segregation distortion among markers arises and its impact on mapping studies are the focus of this work...
  68. pmc The independent distorting ability of the Enhancer of Segregation Distortion, E(SD), in Drosophila melanogaster
    R G Temin
    Laboratory of Genetics, University of Wisconsin Madison 53706
    Genetics 128:339-56. 1991
    b>Segregation distortion is a meiotic drive system, discovered in wild populations, in which males heterozygous for an SD chromosome and a sensitive SD+ homolog transmit the SD chromosome almost exclusively...
  69. ncbi Segregation ratios within Segregation Distorter lines of Drosophila melanogaster conform to a beta-binomial distribution
    C B Sharp
    Department of Molecular Biology and Genetics, University of Guelph, Ontario, Canada
    Genet Res 55:165-70. 1990
    ..The demonstration that the prior distribution of segregation ratios of SD lines can generally be approximated with a beta distribution is crucial for the biometrical analysis of segregation distortion.
  70. ncbi Evolution of segregation distortion: potential for a high degree of polymorphism
    M van Boven
    Department of Genetics, University of Groningen, Haren, The Netherlands
    J Theor Biol 192:131-42. 1998
    By means of a population genetical model, we study the evolution of segregation distortion. Most models of segregation distortion focus on a single distorter allele...
  71. ncbi Single sperm analysis of the CAG repeats in the gene for dentatorubral-pallidoluysian atrophy (DRPLA): the instability of the CAG repeats in the DRPLA gene is prominent among the CAG repeat diseases
    Y Takiyama
    Department of Neurology, Jichi Medical School, 3311 1 Minamikawachi, Kawachi, Tochigi 329 0498, Japan
    Hum Mol Genet 8:453-7. 1999
    ..161) from the expected 1:1 segregation ratio, and thus segregation distortion of expanded alleles in meiosis in male patients with DRPLA was not demonstrated.
  72. pmc Epistatic control of non-Mendelian inheritance in mouse interspecific crosses
    X Montagutelli
    Unite de Genetique des Mammiferes, Institut Pasteur, Paris, France
    Genetics 143:1739-52. 1996
    ..for this deviation from Mendelian expectations is not yet known but it is probably based on lethality of embryos carrying particular combinations of alleles rather than true segregation distortion during oogenesis in F1 hybrid females.
  73. ncbi Modification of Ran GTPase-activating protein by the small ubiquitin-related modifier SUMO-1 requires Ubc9, an E2-type ubiquitin-conjugating enzyme homologue
    G W Lee
    Brigham and Women s Hospital, Division of Rheumatology, Boston, Massachusetts 02115, USA
    J Biol Chem 273:6503-7. 1998
    Covalent modification of the Ran GTPase-activating protein RanGAP1 with the ubiquitin-related protein SUMO-1 promotes its association with Nup358, a component of the cytoplasmic fibrils emanating from the nuclear pore complex (1,2)...
  74. ncbi T-DNA mediated disruption of essential gametophytic genes in Arabidopsis is unexpectedly rare and cannot be inferred from segregation distortion alone
    S Bonhomme
    INRA Station de Génétique et d Amélioration des Plantes, Centre de Versailles Grignon, Versailles, France
    Mol Gen Genet 260:444-52. 1998
    ..Mutants can therefore be screened on the basis of segregation distortion for a reporter resistance gene contained in the T-DNA...
  75. ncbi A novel mammalian Smt3-specific isopeptidase 1 (SMT3IP1) localized in the nucleolus at interphase
    T Nishida
    School of Life Science, Tokyo University of Parmacy and Life Science, Japan
    Eur J Biochem 267:6423-7. 2000
    ..SMT3IP1 expressed by the baculovirus-expression system had the ability to cleave SUMO-1 or Smt3b from SUMO-1/RanGAP1 or Smt3b/RanGAP1 conjugates, respectively, and the activity was a little stronger towards the Smt3b conjugate ..
  76. pmc A genetic map of Gibberella zeae (Fusarium graminearum)
    J E Jurgenson
    Department of Biology, University of Northern Iowa, Cedar Falls, Iowa 50614, USA
    Genetics 160:1451-60. 2002
    ..Three of the nine linkage groups contain regions in which there are high levels of segregation distortion. Selection for the nitrate-utilizing recombinant progeny can explain two of the three skewed regions...
  77. ncbi Phylogeography of sex ratio and multiple mating in stalk-eyed flies from southeast Asia
    Gerald S Wilkinson
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Genetica 117:37-46. 2003
    ..Coevolution between segregation distortion and modifiers should produce transient SR distortion while selection can result in a stable polymorphism...
  78. ncbi Genetic mapping and QTL analysis of fiber-related traits in cotton ( Gossypium)
    M Mei
    Department of Soil and Crop Sciences, Texas A and M University, College Station, TX 77840 2474, USA
    Theor Appl Genet 108:280-91. 2004
    ..b>Segregation distortion was observed in 30 out of 392 loci mapped in cotton...
  79. ncbi [Mapping by molecular markers showing segregation distortion]
    Jun Tan
    Department of Agronomy, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310029, China
    Yi Chuan 26:356-8. 2004
    ..It is better to use the molecular marker showing segregation distortion for constructing a genetic map, in the case of seriously skew segregation between both the adjoining ..
  80. ncbi A new intervarietal linkage map and its application for quantitative trait locus analysis of "gigas" features in bread wheat
    Kazuhiro Suenaga
    International Maize and Wheat Improvement Center, Mexico, D F, Mexico
    Genome 48:65-75. 2005
    ..0 cM. Loci with segregation distortion were clustered on chromosomes 1A, 4B, 4D, 5A, 6A, 6B, and 6D...
  81. ncbi Modeling segregation distortion for viability selection. I. Reconstruction of linkage maps with distorted markers
    Chengsong Zhu
    Section on Statistical Genomics, State Key Laboratory of Crop Genetics and Germplasm Enhancement National Center for Soybean Improvement, College of Agriculture, Nanjing Agricultural University, Nanjing, 210095, People s Republic of China
    Theor Appl Genet 114:295-305. 2007
    ..Results showed that the adjusted linkage maps can be used for further QTL or segregation distortion locus (SDL) analysis unless there are strong evidences to prove that all markers show normal Mendelian ..
  82. ncbi Identification and characterization of segregation distortion loci along chromosome 5B in tetraploid wheat
    Sunil Kumar
    Department of Plant Sciences, Loftsgard Hall, North Dakota State University, Fargo, ND 58105, USA
    Mol Genet Genomics 278:187-96. 2007
    b>Segregation distortion genes are widespread in plants and animals and function by their effect on competition among gametes for preferential fertilization...
  83. doi Genetic properties of the maize nested association mapping population
    Michael D McMullen
    United States Department of Agriculture Agriculture Research Service USDA ARS, USA
    Science 325:737-40. 2009
    ..identified evidence for numerous minor single-locus effects but little two-locus linkage disequilibrium or segregation distortion, which indicated a limited role for genes with large effects and epistatic interactions on fitness...
  84. doi A rice DEAD-box protein, OsRH36, can complement an Arabidopsis atrh36 mutant, but cannot functionally replace its yeast homolog Dbp8p
    Chun Kai Huang
    Department of Life Science, National Central University, Zhongli, Taoyuan County, Taiwan, ROC
    Plant Mol Biol 74:119-28. 2010
    ..complementation tests among three homologous DEAD-box protein genes indicated that OsRH36 can restore segregation distortion in the Arabidopsis atrh36-1 mutant, but cannot complement the lethal phenotype in the yeast dbp8p mutant...
  85. pmc Insights into species divergence and the evolution of hermaphroditism from fertile interspecies hybrids of Caenorhabditis nematodes
    Gavin C Woodruff
    Department of Biology, University of Maryland, College Park, Maryland 20742, USA
    Genetics 186:997-1012. 2010
    ..These hybrid animals were genotyped at 23 loci, and significant segregation distortion (biased against C. briggsae) was detected at 13 loci...
  86. pmc Identification of biochemically distinct properties of the small ubiquitin-related modifier (SUMO) conjugation pathway in Plasmodium falciparum
    Katherine Reiter
    From the Departments of Biochemistry and Molecular Biology and
    J Biol Chem 288:27724-36. 2013
    ..falciparum E1- and E2-conjugating enzymes interact effectively to recognize and modify RanGAP1, a model mammalian SUMO substrate. However, in heterologous reactions, P...
  87. pmc E2-mediated small ubiquitin-like modifier (SUMO) modification of thymine DNA glycosylase is efficient but not selective for the enzyme-product complex
    Christopher T Coey
    From the Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201 and
    J Biol Chem 289:15810-9. 2014
    ..6 min(-1) and K1/2 = 0.55 μM, suggesting that E2∼SUMO-1 has higher affinity for TDG than for the SUMO targets RanGAP1 and p53 (peptide)...
  88. pmc Resolution of genetic map expansion caused by excess heterozygosity in plant recombinant inbred populations
    Sandra K Truong
    Interdisciplinary Program in Genetics, Texas A and M University, College Station, Texas 77843 Biochemistry and Biophysics Department, Texas A and M University, College Station, Texas 77843
    G3 (Bethesda) 4:1963-9. 2014
    ..This segregation distortion causes the overestimation of recombination frequencies and consequent genetic map expansion...
  89. doi Development and validation of 697 novel polymorphic genomic and EST-SSR markers in the American cranberry (Vaccinium macrocarpon Ait.)
    Brandon Schlautman
    Department of Horticulture, University of Wisconsin Madison, 1575 Linden Dr Madison, WI 53706, USA
    Molecules 20:2001-13. 2015
    ..More than 95% of the 507 loci did not display segregation distortion at the p < 0...
  90. pmc Genetic Map of Triticale Integrating Microsatellite, DArT and SNP Markers
    Mirosław Tyrka
    Department of Biochemistry and Biotechnology, Faculty of Chemistry, Rzeszow University of Technology, Rzeszow, Poland
    PLoS ONE 10:e0145714. 2015
    ..2 cM for chromosome 7B. A total of 512 (31.7%) bin markers showed significant (P < 0.05) segregation distortion across all chromosomes...
  91. doi Distorted segregation in plant hybrids and its implication for evolution
    Wang Zhe
    Ministry of Education Key Laboratory for Biodiversity and Ecological Engineering, Department of Ecology and Evolutionary Biology, Fudan University, Shanghai 200438, China
    Yi Chuan 38:801-10. 2016
    ..resulting in allelic segregation that significantly deviated from the Mendelian ratio, referred to as segregation distortion (SD)...
  92. pmc Genome-Wide Differentiation of Various Melon Horticultural Groups for Use in GWAS for Fruit Firmness and Construction of a High Resolution Genetic Map
    Padma Nimmakayala
    Gus R Douglass Institute and Department of Biology, West Virginia State University Institute, WV, USA
    Front Plant Sci 7:1437. 2016
    ..A high-resolution genetic map with 7153 loci was constructed. Genome-wide segregation distortion and recombination rate across various chromosomes were characterized...
  93. ncbi Mouse model of split hand/foot malformation type I
    Giorgio R Merlo
    Telethon Laboratory CBA, Dulbecco Telethon Medical Institute DTMI, Genova, Italy
    Genesis 33:97-101. 2002
    ..However, incomplete penetrance, variable expressivity, segregation distortion, and syndromic association with other anomalies have so far prevented the identification of the SHFM1 gene(..
  94. ncbi The Ran GTPase regulates kinetochore function
    Alexei Arnaoutov
    Laboratory of Gene Regulation and Development, NICHD, NIH, Building 18, Room 106, 20892, Bethesda, MD, USA
    Dev Cell 5:99-111. 2003
    ..Depletion of Ran's GTPase activating protein (RanGAP1) and its accessory factor (RanBP1) similarly abrogates checkpoint arrest...
  95. pmc Genetic dissection of intermated recombinant inbred lines using a new genetic map of maize
    Yan Fu
    Interdepartmental Genetics Graduate Program, Iowa State University, Ames, Iowa 50011 3467, USA
    Genetics 174:1671-83. 2006
    ..The observations that two segregation distortion regions overlap with maize flowering-time QTL suggest that the altered allele frequencies were a ..
  96. doi Protein interactions in the sumoylation cascade: lessons from X-ray structures
    Zhongshu Tang
    Department of Neurochemistry, Max Planck Institute for Brain Research, Deutschordenstrasse 46, Frankfurt, Germany
    FEBS J 275:3003-15. 2008
    ..the E1 and E2 enzymes Aos1-uba2 and ubc9, or SUMO-1 and E2 together with the E3 ligase RanBP2 and its substrate RanGAP1. Their comparison provides insight into the protein interactions underlying sumoylation, and suggests how SUMO ..
  97. pmc Construction of a consensus linkage map for red clover (Trifolium pratense L.)
    Sachiko Isobe
    Kazusa DNA Research Institute, Kazusa Kamatari 2 6 7, Kisarazu, Chiba, 292 0818, Japan
    BMC Plant Biol 9:57. 2009
    ..For red clover, three genetic linkage maps have been published, but the information in these existing maps has not been integrated...
  98. doi IRREGULAR TRICHOME BRANCH 2 (ITB2) encodes a putative aminophospholipid translocase that regulates trichome branch elongation in Arabidopsis
    Xiaoguo Zhang
    Department of Biology, University of Florida Genetics Institute, University of Florida, Gainesville, FL 32611 8526, USA
    Plant J 60:195-206. 2009
    ..We also found that itb2/ala3 mutant pollen does not grow as well as wild-type pollen, leading to severe segregation distortion. Our results suggest that aminophospholipid translocases play an important role in the polar growth of ..
  99. doi SD3, an Arabidopsis thaliana homolog of TIM21, affects intracellular ATP levels and seedling development
    Hidefumi Hamasaki
    Plant Functional Genomics Research Group, Plant Science Center, RIKEN Yokohama Institute, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Mol Plant 5:461-71. 2012
    ..We have characterized a seedling-lethal mutant segregation distortion 3 (sd3) that showed a very dwarf phenotype when grown in the light and, in the dark, had short hypocotyls ..
  100. doi Use of the advanced backcross-QTL method to transfer seed mineral accumulation nutrition traits from wild to Andean cultivated common beans
    Matthew W Blair
    Universidad Nacional de Colombia, km 12 via Chapinero, Palmira, Valle, Colombia
    Theor Appl Genet 125:1015-31. 2012
    ..b>Segregation distortion around domestication genes made some areas difficult to introgress...
  101. pmc Validation of the effects of molecular marker polymorphisms in LcyE and CrtRB1 on provitamin A concentrations for 26 tropical maize populations
    Raman Babu
    CIMMYT, Apdo Postal 6 641, 06600, Mexico, D F, Mexico
    Theor Appl Genet 126:389-99. 2013
    ..LcyE exhibited significant segregation distortion (SD) in all the eight, while CrtRB1 in five of eight digenic populations studied, with favorable alleles ..

Research Grants16

  1. Thomas M Aune; Fiscal Year: 2014
    ..pathways, these repair mechanisms;ATR, DNA-PKcs, and ATM, and cell cycle checkpoints, JNK2, p53, p21, p27, CHEK2, RANGAP1 are defective resulting in failure of DNA repair and loss of genomic integrity...
  2. ESTHER BETRAN; Fiscal Year: 2014
    ..It is now clear that the testes are subject to strong selection due to male competition, segregation distortion and/or parasite-related conflicts, and this is driving rapid evolution at the protein level and likely in ..
  3. GENETICS OF INSULIN-DEPENDENT DIABETES MELLITUS
    CHESTER ALPER; Fiscal Year: 1991
    ..Finally, the transmission of extended haplotypes from mothers and fathers will be analyzed in all study families to identify haplotypes with segregation distortion (possible human analogs of mouse t- mutants).
  4. MATTHEW SIMON COOK; Fiscal Year: 2014
    ..as small RNA-deficient (Dicer mutant) oocytes will be used to determine whether endo-siRNAs directly regulate Rangap1, and thus RanGTP levels, to facilitate normal spindle assembly...
  5. The Genetics of Parallel Reproductive Isolation in Stickleback Species Pairs
    Catherine L Peichel; Fiscal Year: 2012
    ..Our third aim is to detect regions of the genome causing postzygotic isolation by measuring segregation distortion at SNP markers in these pond-raised hybrids compared with that in control embryos made in the laboratory...
  6. MOLECULAR AND EVOLUTIONARY GENETICS OF SEGREGATION
    CHUNG WU; Fiscal Year: 1992
    ..The target for segregation distortion is the Responder (Rsp) locus: the alleles at the locus are broadly classified as sensitive or insensitive...
  7. INFLUENCE OF SEX AND HLA ON RHEUMATOID ARTHRITIS
    George Moxley; Fiscal Year: 2003
    ..RA families will be studied to determine whether there is segregation distortion of RA-associated HLA haplotypes, that is, whether a child (either affected or not) is more likely than ..
  8. MUTATION IN HYBRIDS OF DROSOPHILA
    Michael Simmons; Fiscal Year: 2000
    ..The traits of this syndrome include an elevated mutation rate, frequent chromosome breakage, segregation distortion and sterility. When the P family is regulated, the incidence or severity of these traits is reduced...
  9. FUNCTIONAL ANALYSIS OF THE T COMPLEX
    John Schimenti; Fiscal Year: 2006
    ..genes within the t complex cause a variety of phenotypes, including embryonic lethality, male infertility, segregation distortion, hybrid sterility, parent-of-origin (imprinting) effects, and sex reversal...
  10. METHODS FOR HUMAN GENETIC LINKAGE MAPPING
    Mary Sara McPeek; Fiscal Year: 2001
    ..Implement and improve programs for detecting segregation distortion, modeling interference, and for robust marker ordering with sperm data...
  11. INDUCED ABORTION AND BREAST CANCER RISK
    De Kun Li; Fiscal Year: 2001
    ....
  12. Exposure to Bisphenol A & Reproductive Effect in Humans
    De Kun Li; Fiscal Year: 2007
    ..The proposed study will evaluate the reproductive effects of BPA in settings where there have been high levels of exposure. The study will also investigate effects in multiple human generations. ..
  13. Prenatal MF Exposure & Miscarriage Risk Among Women
    De Kun Li; Fiscal Year: 2009
    ..The findings from the proposed study will provide much needed confirmation of the recently reported results and advance our understanding of a MF health effect. ..
  14. Mixed Model Approach to Gene Mapping for Complex Traits
    Shizhong Xu; Fiscal Year: 2005
    ..The number, map positions and effects of QTL responsible for ethological divergence between species will be determined by associating mating behavior with polymorphic molecular markers in interspecific backcross hybrids. ..
  15. Prenatal NSAID Use and Miscarriage
    De Kun Li; Fiscal Year: 2008
    ..unreadable] [unreadable]..