RAB18

Summary

Gene Symbol: RAB18
Description: RAB18, member RAS oncogene family
Alias: RAB18LI1, WARBM3, ras-related protein Rab-18, RAB18 small GTPase
Species: human

Top Publications

  1. ncbi Cloning and subcellular localization of novel rab proteins reveals polarized and cell type-specific expression
    A Lutcke
    European Molecular Biology Laboratory, Heidelberg, FRG
    J Cell Sci 107:3437-48. 1994
  2. ncbi Rab18 localizes to lipid droplets and induces their close apposition to the endoplasmic reticulum-derived membrane
    Shintaro Ozeki
    Department of Anatomy and Molecular Cell Biology, Graduate School of Medicine, Nagoya University, Showa, Japan
    J Cell Sci 118:2601-11. 2005
  3. ncbi Regulated localization of Rab18 to lipid droplets: effects of lipolytic stimulation and inhibition of lipid droplet catabolism
    Sally Martin
    Institute for Molecular Bioscience and Centre for Microscopy and Microanalysis, University of Queensland, Brisbane, Queensland 4072, Australia
    J Biol Chem 280:42325-35. 2005
  4. doi Rab18 and Rab43 have key roles in ER-Golgi trafficking
    Selma Y Dejgaard
    Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada H3A2B2
    J Cell Sci 121:2768-81. 2008
  5. pmc Loss-of-function mutations in RAB18 cause Warburg micro syndrome
    Danai Bem
    Medical and Molecular Genetics, School of Clinical and Experimental Medicine and Centre for Rare Diseases and Personalised Medicine, University of Birmingham, Birmingham B15 2TT, UK
    Am J Hum Genet 88:499-507. 2011
  6. doi RAB3GAP1, RAB3GAP2 and RAB18: disease genes in Micro and Martsolf syndromes
    Mark T Handley
    MRC Human Genetics Unit, MRC IGMM, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, Scotland, UK
    Biochem Soc Trans 40:1394-7. 2012
  7. doi Mutation spectrum in RAB3GAP1, RAB3GAP2, and RAB18 and genotype-phenotype correlations in warburg micro syndrome and Martsolf syndrome
    Mark T Handley
    MRC Human Genetics Unit, Medical Research Council and Institute of Genetics and Molecular Medicine, University of Edinburgh, Scotland, UK
    Hum Mutat 34:686-96. 2013
  8. pmc Rab18 binds to hepatitis C virus NS5A and promotes interaction between sites of viral replication and lipid droplets
    Shadi Salloum
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS Pathog 9:e1003513. 2013
  9. pmc Loss-of-function mutations in TBC1D20 cause cataracts and male infertility in blind sterile mice and Warburg micro syndrome in humans
    Ryan P Liegel
    Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Hum Genet 93:1001-14. 2013
  10. pmc Role of Abscisic Acid in Drought-Induced Freezing Tolerance, Cold Acclimation, and Accumulation of LT178 and RAB18 Proteins in Arabidopsis thaliana
    E Mäntylä
    Department of Molecular Genetics, Uppsala Genetic Center, Swedish University of Agricultural Sciences, Box 7010, S 750 07 Uppsala, Sweden
    Plant Physiol 107:141-148. 1995

Scientific Experts

  • Lin Han
  • Juhua Liu
  • Shuqing Cao
  • Thanos Ghelis
  • Kenji Miura
  • Iwona Ciereszko
  • Eiko Tsuiki
  • Lisa M Curtis
  • J Svensson
  • E Miginiac
  • Chang Hyo Goh
  • H Knight
  • U Schaefer
  • Helen H Tai
  • M Nylander
  • Mark T Handley
  • Rafael Vazquez-Martinez
  • Maria M Malagon
  • Irene A Aligianis
  • Marina R Pulido
  • Haitao Shi
  • Sheng Ying
  • David Reyes
  • Toyoshi Fujimoto
  • Sarah M Carpanini
  • Francis A Barr
  • M M Malagon
  • Dolores Rodriguez
  • Sally Martin
  • Carlos Nicolas
  • Gregorio Nicolás
  • Danai Bem
  • Christine Zalejski
  • Yuki Ohsaki
  • Justo P Castaño
  • Robert G Parton
  • Qingqing Fan
  • Asami Makino
  • Qinwei Wu
  • Jinxie Zhang
  • Tendai Mhlanga-Mutangadura
  • Dejing Kong
  • Fiona O'Mahony
  • Danuta Babula-Skowronska
  • Mitsunori Fukuda
  • Ignacio Arroyo-Carrera
  • Mitchell J R Macleod
  • Kangmin Kim
  • Eun Yu Kim
  • Guohua Cai
  • M Kulkarni
  • Alison K Gillingham
  • Chih Ya Cheng
  • Xia Li
  • Keng Zhong
  • Jiafu Jiang
  • Juliana Marcolino-Gomes
  • Sumei Chen
  • Cui Li
  • Wei Chun Tang
  • Aiping Song
  • Andreas Gerondopoulos
  • Qing Liu
  • Fadi Chen
  • Masakazu Tomiyama
  • Hiromichi Dansako
  • Taruho S Kuroda
  • Tiantian Ye
  • Anne Laure Quettier
  • Régis Maldiney
  • Zhulong Chan
  • Emmanuelle Jeannette
  • Sarah Carpanini
  • Ian J Jackson
  • Deborah J Morris-Rosendahl
  • Francesca Faravelli
  • Thomas Gronemeyer
  • Ghada M H Abdel-Salam
  • Shengchun Zhang
  • Patrizia Accorsi
  • Xiaona You
  • Stephen Brown
  • Xiaoxia Li
  • Yanmin Zou
  • Shadi Salloum
  • Ryan P Liegel
  • Lorenzo Pinelli
  • Shin ichiro Yoshimura
  • Alberto Diaz-Ruiz
  • Carina Verónica González

Detail Information

Publications120 found, 100 shown here

  1. ncbi Cloning and subcellular localization of novel rab proteins reveals polarized and cell type-specific expression
    A Lutcke
    European Molecular Biology Laboratory, Heidelberg, FRG
    J Cell Sci 107:3437-48. 1994
    ..mRNA expression in different tissues and the intracellular localization in organ cryosections of two rab proteins, rab18 and rab20...
  2. ncbi Rab18 localizes to lipid droplets and induces their close apposition to the endoplasmic reticulum-derived membrane
    Shintaro Ozeki
    Department of Anatomy and Molecular Cell Biology, Graduate School of Medicine, Nagoya University, Showa, Japan
    J Cell Sci 118:2601-11. 2005
    ..In the present study, we identified Rab18 as an LD component of HepG2 cells by proteomic analysis, and confirmed its localization by immunohistochemistry ..
  3. ncbi Regulated localization of Rab18 to lipid droplets: effects of lipolytic stimulation and inhibition of lipid droplet catabolism
    Sally Martin
    Institute for Molecular Bioscience and Centre for Microscopy and Microanalysis, University of Queensland, Brisbane, Queensland 4072, Australia
    J Biol Chem 280:42325-35. 2005
    ..In contrast, GFP-Rab18 localized to LDs and immunoelectron microscopy showed direct association with the monolayer surface...
  4. doi Rab18 and Rab43 have key roles in ER-Golgi trafficking
    Selma Y Dejgaard
    Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada H3A2B2
    J Cell Sci 121:2768-81. 2008
    ..Further analysis of two of these proteins, Rab18 and Rab43, strongly indicated roles in ER-Golgi trafficking...
  5. pmc Loss-of-function mutations in RAB18 cause Warburg micro syndrome
    Danai Bem
    Medical and Molecular Genetics, School of Clinical and Experimental Medicine and Centre for Rare Diseases and Personalised Medicine, University of Birmingham, Birmingham B15 2TT, UK
    Am J Hum Genet 88:499-507. 2011
    ..mapping in five consanguineous families without RAB3GAP1/2 mutations and identified loss-of-function mutations in RAB18. A c.71T > A (p...
  6. doi RAB3GAP1, RAB3GAP2 and RAB18: disease genes in Micro and Martsolf syndromes
    Mark T Handley
    MRC Human Genetics Unit, MRC IGMM, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, Scotland, UK
    Biochem Soc Trans 40:1394-7. 2012
    ..Micro syndrome has been associated with causative mutations in three disease genes: RAB3GAP1, RAB3GAP2 and RAB18. Martsolf syndrome has been associated with a mutation in RAB3GAP2...
  7. doi Mutation spectrum in RAB3GAP1, RAB3GAP2, and RAB18 and genotype-phenotype correlations in warburg micro syndrome and Martsolf syndrome
    Mark T Handley
    MRC Human Genetics Unit, Medical Research Council and Institute of Genetics and Molecular Medicine, University of Edinburgh, Scotland, UK
    Hum Mutat 34:686-96. 2013
    ..Causative biallelic germline mutations have been identified in RAB3GAP1, RAB3GAP2, or RAB18, each of which encode proteins involved in membrane trafficking...
  8. pmc Rab18 binds to hepatitis C virus NS5A and promotes interaction between sites of viral replication and lipid droplets
    Shadi Salloum
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS Pathog 9:e1003513. 2013
    ..Using an unbiased proteomic strategy, we have found that Rab18 interacts with the HCV nonstructural protein NS5A...
  9. pmc Loss-of-function mutations in TBC1D20 cause cataracts and male infertility in blind sterile mice and Warburg micro syndrome in humans
    Ryan P Liegel
    Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Hum Genet 93:1001-14. 2013
    ..disorders characterized by eye, brain, and endocrine abnormalities caused by mutations in RAB3GAP1, RAB3GAP2, and RAB18. Sequence analysis of a cohort of 77 families affected by WARBM identified five distinct TBC1D20 loss-of-function ..
  10. pmc Role of Abscisic Acid in Drought-Induced Freezing Tolerance, Cold Acclimation, and Accumulation of LT178 and RAB18 Proteins in Arabidopsis thaliana
    E Mäntylä
    Department of Molecular Genetics, Uppsala Genetic Center, Swedish University of Agricultural Sciences, Box 7010, S 750 07 Uppsala, Sweden
    Plant Physiol 107:141-148. 1995
    ..enhanced freezing tolerance with the presence of stress-specific proteins, we characterized the accumulation of RAB18 and LTI78 in two ecotypes, Landsberg erecta and Coimbra, and in the ABA mutants during stress response...
  11. pmc HAB1-SWI3B interaction reveals a link between abscisic acid signaling and putative SWI/SNF chromatin-remodeling complexes in Arabidopsis
    Angela Saez
    Instituto de Biologia Molecular y Celular de Plantas, Consejo Superior de Investigaciones Cientificas Universidad Politecnica de Valencia, ES 46022 Valencia, Spain
    Plant Cell 20:2972-88. 2008
    ..to ABA-mediated inhibition of seed germination and growth and reduced expression of the ABA-responsive genes RAB18 and RD29B...
  12. doi Methylglyoxal inhibits seed germination and root elongation and up-regulates transcription of stress-responsive genes in ABA-dependent pathway in Arabidopsis
    T S Hoque
    Division of Bioscience, Graduate School of Natural Science and Technology, Okayama University, Okayama, Japan
    Plant Biol (Stuttg) 14:854-8. 2012
    ..MG increased transcription levels of RD29B and RAB18 in a dose-dependent manner but did not affect RD29A transcription level...
  13. pmc Alleviation of salt stress by enterobacter sp. EJ01 in tomato and Arabidopsis is accompanied by up-regulation of conserved salinity responsive factors in plants
    Kangmin Kim
    Division of Biotechnology, College of Environmental and Bioresource Sciences
    Mol Cells 37:109-17. 2014
    ..treatment with EJ01 increased the expression of salt stress responsive genes such as DREB2b, RD29A, RD29B, and RAB18 in Arabidopsis. The expression of proline biosynthetic genes (i.e...
  14. pmc Mg-chelatase I subunit 1 and Mg-protoporphyrin IX methyltransferase affect the stomatal aperture in Arabidopsis thaliana
    Masakazu Tomiyama
    Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa, Nagoya, 464 8602, Japan
    J Plant Res 127:553-63. 2014
    ..However, lost1 and chlm seedlings all showed normal expression of ABA-induced genes, such as RAB18 and RD29B, in response to ABA...
  15. doi A maize mitogen-activated protein kinase kinase, ZmMKK1, positively regulated the salt and drought tolerance in transgenic Arabidopsis
    Guohua Cai
    State Key Laboratory of Crop Biology, Shandong Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University, Tai an 271018, Shandong, China
    J Plant Physiol 171:1003-16. 2014
    ..ZmMKK1 in Arabidopsis enhanced the expression of ROS scavenging enzyme- and ABA-related genes, such as POD, CAT, RAB18 and RD29A under salt and drought conditions...
  16. doi Overexpression of CaDSR6 increases tolerance to drought and salt stresses in transgenic Arabidopsis plants
    Eun Yu Kim
    Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, Seoul 120 749, Republic of Korea
    Gene 552:146-54. 2014
    ..The expression of drought-induced marker genes, such as RD20, RD22, RD26, RD29A, RD29B, RAB18, KIN2, ABF3, and ABI5, was markedly increased in CaDSR6-overexpressing plants relative to wild type plants under ..
  17. pmc MicroRNA-30b/c inhibits non-small cell lung cancer cell proliferation by targeting Rab18
    Keng Zhong
    Department of Cardiothoracic Surgery, Changhai Hospital Affiliated to Second Military Medical University, Shanghai 200433, China
    BMC Cancer 14:703. 2014
    ..The aim of this study was to investigate the target gene of miR-30 and its roles in tumor growth of NSCLC...
  18. doi Identification of TaWD40D, a wheat WD40 repeat-containing protein that is associated with plant tolerance to abiotic stresses
    Dejing Kong
    The State Key Laboratory of Plant Cell and Chromosome Engineering, Center of Agricultural Resources Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 286 Huaizhong Road, Shijiazhuang, 050021, Hebei, China
    Plant Cell Rep 34:395-410. 2015
    ..The expression patterns of two genes from the SOS pathway (SOS2 and SOS3) and three ABA genes (ABI2, RAB18 and DREB2A) functioning in ABA-dependent and ABA-independent pathways were altered in the transgenic lines ..
  19. pmc Liver X receptors balance lipid stores in hepatic stellate cells through Rab18, a retinoid responsive lipid droplet protein
    Fiona O'Mahony
    Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, 90025, USA
    Hepatology 62:615-26. 2015
    ..We identify Rab18 as a novel retinoic acid-responsive, LD-associated protein that helps mediate stellate cell activation...
  20. doi Exposure of two Eutrema salsugineum (Thellungiella salsuginea) accessions to water deficits reveals different coping strategies in response to drought
    Mitchell J R Macleod
    Department of Biology, McMaster University, Hamilton, ON, L8S 4K1, Canada
    Physiol Plant 155:267-80. 2015
    ..The drought-responsive expression of dehydrin genes RAB18, ERD1, RD29A and RD22 showed greater changes in transcript abundance in Yukon relative to Shandong leaves during ..
  21. doi Deletion 1q43-44 in a patient with clinical diagnosis of Warburg-Micro syndrome
    Ignacio Arroyo-Carrera
    Servicio de Pediatria, Hospital San Pedro de Alcantara, Caceres, Spain
    Am J Med Genet A 167:1243-51. 2015
    ..This syndrome is caused by mutations in the RAB3GAP1/2 and RAB18 genes, part of the Rab family, and in the TBC1D20 gene, which contributes to lipid droplet formation/metabolism...
  22. pmc Involvement of genes encoding ABI1 protein phosphatases in the response of Brassica napus L. to drought stress
    Danuta Babula-Skowronska
    Institute of Plant Genetics, Polish Academy of Sciences, Strzeszynska 34, 60 479, Poznan, Poland
    Plant Mol Biol 88:445-57. 2015
    ..to drought showed a decrease in relative water content, photosynthetic pigments content and expression level of RAB18- and RD19A-drought-responsive marker genes relative to WT plants...
  23. doi A mutation in the Warburg syndrome gene, RAB3GAP1, causes a similar syndrome with polyneuropathy and neuronal vacuolation in Black Russian Terrier dogs
    Tendai Mhlanga-Mutangadura
    Department of Veterinary Pathobiology, University of Missouri, Columbia, USA
    Neurobiol Dis 86:75-85. 2016
    ..RAB3GAP1 encodes the catalytic subunit of a GTPase activator protein and guanine exchange factor for Rab3 and Rab18 respectively...
  24. pmc RAB18, a protein associated with Warburg Micro syndrome, controls neuronal migration in the developing cerebral cortex
    Qinwei Wu
    Peking Tsinghua Center for Life Sciences, Peking University, Beijing, 100871, China
    Mol Brain 9:19. 2016
    Loss of function mutations in RAB18, has been identified in patients with the human neurological and developmental disorder Warburg Micro syndrome. However, the function of RAB18 in brain remains unknown.
  25. pmc CmWRKY1 Enhances the Dehydration Tolerance of Chrysanthemum through the Regulation of ABA-Associated Genes
    Qingqing Fan
    College of Horticulture, Nanjing Agricultural University, Nanjing, 210095, China
    PLoS ONE 11:e0150572. 2016
    ..2, ABF4, MYB2, RAB18, and DREB1A...
  26. pmc Acute accumulation of free cholesterol induces the degradation of perilipin 2 and Rab18-dependent fusion of ER and lipid droplets in cultured human hepatocytes
    Asami Makino
    INSERM RIKEN Lipidomics Unit, Universite Lyon 1, 69621 Villeurbanne, France
    Mol Biol Cell 27:3293-3304. 2016
    ..The results indicate that association of ApoB 100 with LDs is dependent on the activity of low-molecular weight GTP-binding protein Rab18 and highlight the role of LDs as targets of free cholesterol toxicity in hepatocytes.
  27. pmc Intracellular Trafficking Network of Protein Nanocapsules: Endocytosis, Exocytosis and Autophagy
    Jinxie Zhang
    School of Life Sciences, Tsinghua University, Beijing 100084, P R China Division of Life and Health Sciences, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, P R China
    Theranostics 6:2099-2113. 2016
    ..novel transport pathways: micropinocytosis (Rab34 positive)-LEs (Rab7 positive)-lysosome pathway and EEs-liposome (Rab18 positive)-lysosome pathway...
  28. pmc Negative regulation of abscisic acid signaling by the Fagus sylvatica FsPP2C1 plays a role in seed dormancy regulation and promotion of seed germination
    Mary Paz Gonzalez-Garcia
    Departamento de Fisiologia Vegetal, Centro Hispano Luso de Investigaciones Agrarias, Facultad de Biologia, Universidad de Salamanca, 37007 Salamanca, Spain
    Plant Physiol 133:135-44. 2003
    ..FsPP2C1 transgenic plants show ABA-resistant early root growth and diminished induction of the ABA-response genes RAB18 and KIN2, but no effect on stomatal closure regulation...
  29. pmc Structural investigation of disordered stress proteins. Comparison of full-length dehydrins with isolated peptides of their conserved segments
    Jean Marie Mouillon
    Department of Chemistry and Biomedical Sciences, Kalmar University, S 391 82 Kalmar, Sweden
    Plant Physiol 141:638-50. 2006
    ..analysis of four full-length dehydrins from Arabidopsis (Arabidopsis thaliana; Cor47, Lti29, Lti30, and Rab18) and isolated peptide mimics of the K-, Y-, and Lys-rich segments...
  30. doi SUMO E3 ligase AtMMS21 regulates drought tolerance in Arabidopsis thaliana(F)
    Shengchun Zhang
    Guangdong Key Lab of Biotechnology for Plant Development, College of Life Science, South China Normal University, Guangzhou 510631, China
    J Integr Plant Biol 55:83-95. 2013
    ..genes, including COR15A, RD22, and P5CS1 The ABA and drought-induced stress-responsive genes, including RAB18, RD29A and RD29B, were inhibited by constitutive expression of MMS21...
  31. doi Arabidopsis ALTERED MERISTEM PROGRAM 1 negatively modulates plant responses to abscisic acid and dehydration stress
    Haitao Shi
    Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan 430074, China
    Plant Physiol Biochem 67:209-16. 2013
    ..Notably, the amp1-1 lines exhibited higher expression levels of ABA-responsive genes (RAB18, RD29A and RD29B), higher concentration of proline and lower reactive oxygen species (ROS) levels (H2O2 and O2(-)) ..
  32. doi Overexpression of tomato SpMPK3 gene in Arabidopsis enhances the osmotic tolerance
    Cui Li
    State Key Laboratory of Crop Stress Biology in Arid Region, Northwest A and F University, Yangling 712100, Shaanxi, PR China College of Horticulture, Northwest A and F University, Yangling 712100, Shaanxi, PR China
    Biochem Biophys Res Commun 443:357-62. 2014
    ..In addition, SpMPK3 overexpression enhanced the transcription levels of ABA inducible genes-RD29A, RAB18 and RD22, and transcription factor genes-ZAT6, ZAT10 and MYB44, in transgenic Arabidopsis compared with wild-type ..
  33. pmc Diurnal oscillations of soybean circadian clock and drought responsive genes
    Juliana Marcolino-Gomes
    Embrapa Soybean, Brazilian Agricultural Research Corporation, Londrina, Parana, Brazil Department of Biology, State University of Londrina, Londrina, Parana, Brazil
    PLoS ONE 9:e86402. 2014
    ..Similarly, the rhythmic expression pattern of the soybean drought-responsive genes DREB-, bZIP-, GOLS-, RAB18- and Remorin-like changed significantly after plant exposure to drought...
  34. doi miR-200b as a prognostic factor targets multiple members of RAB family in glioma
    Qing Liu
    Department of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiang Ya Road, Changsha, 410078, Hunan, People s Republic of China
    Med Oncol 31:859. 2014
    ..And its downexpression was correlated with poor prognosis in gliomas. Members of RAB family, RAB21, RAB23, RAB18 and RAB3B were predicted to be novel targets of miR-200b...
  35. pmc Rab18 facilitates dengue virus infection by targeting fatty acid synthase to sites of viral replication
    Wei Chun Tang
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    J Virol 88:6793-804. 2014
    ..The Rab18 protein, a member of the Rab GTPase family, key regulators of membrane trafficking, is located on the organelles ..
  36. pmc A novel mouse model of Warburg Micro syndrome reveals roles for RAB18 in eye development and organisation of the neuronal cytoskeleton
    Sarah M Carpanini
    MRC Human Genetics Unit, Institute for Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK The Roslin Institute, University of Edinburgh, Edinburgh EH25 9RG, UK
    Dis Model Mech 7:711-22. 2014
    Mutations in RAB18 have been shown to cause the heterogeneous autosomal recessive disorder Warburg Micro syndrome (WARBM). Individuals with WARBM present with a range of clinical symptoms, including ocular and neurological abnormalities...
  37. pmc Rab18 and a Rab18 GEF complex are required for normal ER structure
    Andreas Gerondopoulos
    Department of Biochemistry, University of Oxford, Oxford OX1 3QU, England, UK
    J Cell Biol 205:707-20. 2014
    The ancestral Rab GTPase Rab18 and both subunits of the Rab3GAP complex are mutated in the human neurological and developmental disorder Warburg Micro syndrome...
  38. doi Modulation of auxin content in Arabidopsis confers improved drought stress resistance
    Haitao Shi
    Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan 430074, China
    Plant Physiol Biochem 82:209-17. 2014
    ..and exogenous auxin positively modulated the expression levels of multiple abiotic stress-related genes (RAB18, RD22, RD29A, RD29B, DREB2A, and DREB2B), and positively affected reactive oxygen species (ROS) metabolism and ..
  39. doi The association of RAB18 gene polymorphism (rs3765133) with cerebellar volume in healthy adults
    Chih Ya Cheng
    Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan
    Cerebellum 13:616-22. 2014
    ..Loss-of-function mutations in the RAB18 gene (RAB18) cause Warburg Micro syndrome, which is associated with reduced brain size and deformed brain ..
  40. doi Rab18 is required for viral assembly of hepatitis C virus through trafficking of the core protein to lipid droplets
    Hiromichi Dansako
    Department of Tumor Virology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Kita ku, Okayama 700 8558, Japan
    Virology 462:166-74. 2014
    ..Here, we demonstrated that one of the Ras-related small GTPases, Rab18, was required for trafficking of the core protein around LDs...
  41. pmc Toward a comprehensive map of the effectors of rab GTPases
    Alison K Gillingham
    MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK
    Dev Cell 31:358-73. 2014
    ..We confirm over 25 interactions for Rab2, Rab4, Rab5, Rab6, Rab7, Rab9, Rab18, Rab19, Rab30, and Rab39...
  42. ncbi The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain
    Taruho S Kuroda
    Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, Saitama, Japan
    J Biol Chem 277:9212-8. 2002
    ..but not of the other Rabs tested (Rab1, Rab2, Rab3A, Rab4, Rab5A, Rab6A, Rab7, Rab8, Rab9, Rab10, Rab11A, Rab17, Rab18, Rab20, Rab22, Rab23, Rab25, Rab28, and Rab37)...
  43. ncbi TbRAB18, a developmentally regulated Golgi GTPase from Trypanosoma brucei
    Tim R Jeffries
    Department of Biological Sciences and Centre for Molecular Microbiology and Infection, Wellcome Trust Laboratories for Molecular Parasitology, Imperial College of Science, Technology and Medicine, Exhibition Road, London, UK
    Mol Biochem Parasitol 121:63-74. 2002
    ..Finally, the location, and hence function, of TbRAB18 are distinct from the closest metazoan homologue, murine Rab18; the latter protein is involved in endocytic transport pathways whilst clearly TbRAB18 is not...
  44. ncbi Phospholipase D is a negative regulator of proline biosynthesis in Arabidopsis thaliana
    Laurent Thiery
    Unité de Physiologie Cellulaire et Moléculaire des Plantes, UMR 7632 CNRS, Universite Pierre and Marie Curie, case 156, 4 place Jussieu, 75252 Paris Cedex 05, France
    J Biol Chem 279:14812-8. 2004
    ..for proline biosynthesis is similar to RD29A gene expression and different from the abscisic acid-dependent RAB18 gene expression...
  45. ncbi Isolation and characterization of novel mutants affecting the abscisic acid sensitivity of Arabidopsis germination and seedling growth
    Noriyuki Nishimura
    Graduate School of Integrated Science, Yokohama City University, 1 7 29 Suehiro, Tsurumi, Yokohama, 230 0045 Japan
    Plant Cell Physiol 45:1485-99. 2004
    ..RT-PCR experiments showed that the expression patterns of the ABA-inducible genes RAB18, AtEm1, AtEm6 and ABI5 in germinating seeds were affected by these four ahg mutations, whereas those of ABI3 and ..
  46. ncbi Diacylglycerol pyrophosphate is a second messenger of abscisic acid signaling in Arabidopsis thaliana suspension cells
    Christine Zalejski
    Physiologie Cellulaire et Moléculaire des Plantes, Unité Mixte de Recherche 7632 Centre National de la Recherche Scientifique, case 156, Universite Pierre et Marie Curie, Le Raphaël, 3 rue Galilée 94200 Ivry sur Seine, France
    Plant J 42:145-52. 2005
    ..the stimulation of phospholipase D (PLD) activity and plasma membrane anion currents by ABA were both required for RAB18 expression in Arabidopsis thaliana suspension cells...
  47. ncbi Fixation and permeabilization protocol is critical for the immunolabeling of lipid droplet proteins
    Yuki Ohsaki
    Department of Anatomy and Molecular Cell Biology, Graduate School of Medicine, Nagoya University, 65 Tsurumai, 466 8550, Nagoya, Showa, Japan
    Histochem Cell Biol 124:445-52. 2005
    ..of cultured cells, was not appropriate to label adipocyte differentiation-related protein (ADRP), TIP47, or Rab18 in LDs...
  48. ncbi Evidence of a role for tyrosine dephosphorylation in the control of postgermination arrest of development by abscisic acid in Arabidopsis thaliana L
    David Reyes
    Departamento de Fisiologia Vegetal, Facultad de Biologia, Centro Hispano Luso de Investigaciones Agrarias, Universidad de Salamanca, Plaza de los Doctores de la Reina s n, 37007 Salamanca, Spain
    Planta 223:381-5. 2006
    ..Consistent with this finding, we demonstrate that the ABA-responsive gene, RAB18, is hyperinduced in seeds imbibed in ABA plus PAO, compared with seeds imbibed only with ABA.
  49. pmc Overexpression of a protein phosphatase 2C from beech seeds in Arabidopsis shows phenotypes related to abscisic acid responses and gibberellin biosynthesis
    David Reyes
    Departamento de Fisiologia Vegetal, Centro Hispano Luso de Investigaciones Agrarias, Facultad de Biologia, Universidad de Salamanca, 37007 Salamanca, Spain
    Plant Physiol 141:1414-24. 2006
    ..Additionally, FsPP2C2-overexpressing plants showed a strong induction of the Responsive to ABA 18 (RAB18) gene...
  50. doi Use of a fibrin-based system for enhancing angiogenesis and modulating inflammation in the treatment of hyperglycemic wounds
    M Kulkarni
    Network of Excellence for Functional Biomaterials, National University of Ireland, Galway, Ireland
    Biomaterials 35:2001-10. 2014
    ..In the hyper-secretory wound microenvironment of hyperglycemia, Rab18, a secretory control molecule, was found to be significantly downregulated...
  51. doi Hepatitis B virus X protein upregulates oncogene Rab18 to result in the dysregulation of lipogenesis and proliferation of hepatoma cells
    Xiaona You
    Department of Cancer Research, Key Laboratory of Molecular Microbiology and Technology of Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China
    Carcinogenesis 34:1644-52. 2013
    ..In this study, we report that the oncogene Rab18, a member of Ras family, enhances the HBx-induced hepatocarcinogenesis through inducing dysregulation of ..
  52. doi LcSAIN1, a novel salt-induced gene from sheepgrass, confers salt stress tolerance in transgenic Arabidopsis and rice
    Xiaoxia Li
    Key Laboratory of Plant Resources, Institute of Botany, The Chinese Academy of Sciences, Beijing, PR China
    Plant Cell Physiol 54:1172-85. 2013
    ..role in increasing the expression of transcription factors (MYB2 and DREB2A) and functional genes (P5CS and RAB18) in transgenic plants under salt stress and that it augments stress tolerance through the accumulation of ..
  53. pmc miR172b controls the transition to autotrophic development inhibited by ABA in Arabidopsis
    Yanmin Zou
    Key State Laboratory of Plant Cell and Chromosome Engineering, Center of Agricultural Resources Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Shijiazhuang, Hebei, China
    PLoS ONE 8:e64770. 2013
    ..post-germinative stage, and resulted in higher expression of ABI3, ABI5 and downstream genes, such as Em6 and RAB18, than wild type under ABA treatment...
  54. doi Cloning and characterization of a maize bZIP transcription factor, ZmbZIP72, confers drought and salt tolerance in transgenic Arabidopsis
    Sheng Ying
    Institute of Crop Science, Chinese Academy of Agricultural Sciences, Beijing 100081, China
    Planta 235:253-66. 2012
    ..Moreover, overexpression of ZmbZIP72 enhanced the expression of ABA-inducible genes such as RD29B, RAB18, and HIS1-3...
  55. doi Heterologous expression of the chrysanthemum R2R3-MYB transcription factor CmMYB2 enhances drought and salinity tolerance, increases hypersensitivity to ABA and delays flowering in Arabidopsis thaliana
    Hong Shan
    College of Horticulture, Nanjing Agricultural University, Nanjing 210095, China
    Mol Biotechnol 51:160-73. 2012
    ..The level of expression of a number of genes associated with the stress response, including RD22, RD29A, RAB18, COR47, ABA1 and ABA2, was raised in the CmMYB2 transgenic Arabidopsis plants...
  56. doi GsZFP1, a new Cys2/His2-type zinc-finger protein, is a positive regulator of plant tolerance to cold and drought stress
    Xiao Luo
    Plant Bioengineering Laboratory, Northeast Agricultural University, Harbin 150030, China
    Planta 235:1141-55. 2012
    ..stress-response marker genes, including CBF1, CBF2, CBF3, NCED3, COR47, and RD29A in response to cold stress and RAB18, NCED3, P5CS, RD22, and RD29A in response to drought stress, especially early during stress treatments...
  57. doi Phytochrome B increases drought tolerance by enhancing ABA sensitivity in Arabidopsis thaliana
    Carina Verónica González
    IBAM Instituto de Biología Agrícola de Mendoza, CONICET Universidad Nacional de Cuyo, Facultad de Ciencias Agrarias, Alte Brown 500 5505, Chacras de Coria, Lujan de Cuyo, Mendoza, Argentina
    Plant Cell Environ 35:1958-68. 2012
    ..Furthermore, the expression of RAB18 and RD29A, both typical ABA-induced genes, was lower in phyB than the wild type after ABA treatment...
  58. pmc Are Rab proteins the link between Golgi organization and membrane trafficking?
    Shijie Liu
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Cell Mol Life Sci 69:4093-106. 2012
    ..These include Rab6, Rab33B, Rab1, Rab2, Rab18, and Rab43. In yeast, these include Ypt1, Ypt32, and Ypt6...
  59. pmc Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction
    M Ayalew
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA
    Mol Psychiatry 17:887-905. 2012
    ..polyevidence scoring and pathway analyses, we identify top genes (DISC1, TCF4, MBP, MOBP, NCAM1, NRCAM, NDUFV2, RAB18, as well as ADCYAP1, BDNF, CNR1, COMT, DRD2, DTNBP1, GAD1, GRIA1, GRIN2B, HTR2A, NRG1, RELN, SNAP-25, TNIK), brain ..
  60. pmc Rab proteins and the secretory pathway: the case of rab18 in neuroendocrine cells
    Rafael Vazquez-Martinez
    Department of Cell Biology, Physiology and Immunology, University of Cordoba Cordoba, Spain
    Front Endocrinol (Lausanne) 2:1. 2011
    ..Furthermore, we also summarize the information available on a particular Rab protein, Rab18, which has been linked to the control of secretory granule traffic in neuroendocrine cells.
  61. doi Nutritional, hormonal, and depot-dependent regulation of the expression of the small GTPase Rab18 in rodent adipose tissue
    Marina R Pulido
    Department of Cell Biology, Physiology and Immunology, Instituto Maimonides de Investigacion Biomedica de Cordoba, University of Córdoba Hospital Universitario Reina Sofia, Edificio Severo Ochoa, Pl 3, Campus Univ de Rabanales, E 14014 Cordoba, Spain
    J Mol Endocrinol 50:19-29. 2013
    ..The small GTPase, RAB18, has been recently identified as a novel component of the protein coat of LDs and proposed to play a role in both ..
  62. doi Isolation of an abscisic acid senescence and ripening inducible gene from litchi and functional characterization under water stress
    Juhua Liu
    Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, 4 Xueyuan Road, 571101, Haikou, China
    Planta 237:1025-36. 2013
    ..The levels of several ABA/stress-regulated genes were investigated. The transcript level of responsive to ABA (RAB18) remained constant and responsive to dehydration (RD29A) displayed a slight decrease in the Columbia line (Col)...
  63. doi Localization of Rab proteins to peroxisomes: a proteomics and immunofluorescence study
    Thomas Gronemeyer
    Department of Molecular Genetics and Cell Biology, Ulm University, Germany
    FEBS Lett 587:328-38. 2013
    ..and immunofluorescence analysis of the peroxisome candidate Rab proteins revealed Rab6, Rab10, Rab14 and Rab18 to associate with the peroxisomal membrane...
  64. ncbi The expression of a rab-related gene, rab18, is induced by abscisic acid during the cold acclimation process of Arabidopsis thaliana (L.) Heynh
    V Lang
    Department of Molecular Genetics, Swedish University of Agricultural Sciences, Uppsala
    Plant Mol Biol 20:951-62. 1992
    We have isolated a rab-related (responsive to ABA) gene, rab18 from Arabidopsis thaliana. The gene encodes a hydrophilic, glycine-rich protein (18...
  65. ncbi Gene cloning and characterization of a GTP-binding Rab protein from mouse pituitary AtT-20 cells
    H Yu
    Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Gene 132:273-8. 1993
    ..Here, we report the identification and studies of one of the clones, RAB18. The full-length cDNA clone from a mouse pituitary AtT-20 cDNA library encodes a 23...
  66. ncbi Characterization and differential expression of dhn/lea/rab-like genes during cold acclimation and drought stress in Arabidopsis thaliana
    B V Welin
    Department of Molecular Genetics, Uppsala Genetic Center, Swedish University of Agricultural Sciences, Uppsala
    Plant Mol Biol 26:131-44. 1994
    ..The expression pattern of the five dhn/lea/rab-related genes (cor47, dhnX, lti30, lti45 and rab18) identified so far in A...
  67. pmc Characterization of a ferritin mRNA from Arabidopsis thaliana accumulated in response to iron through an oxidative pathway independent of abscisic acid
    F Gaymard
    Centre National de la Recherche Scientifique Unité de Recherche 2133, Institut National de la Recherche Agronomique, Montpellier, France
    Biochem J 318:67-73. 1996
    ..In contrast to maize, the transcript abundance of a gene responding to abscisic acid (RAB18) did not increase in response to iron loading treatment, and A...
  68. ncbi Rab17 and rab18, small GTPases with specificity for polarized epithelial cells: genetic mapping in the mouse
    E B McMurtrie
    Department of Medicine, University of Florida, Gainesville, Florida, 32610 0221, USA
    Genomics 45:623-5. 1997
    ..While most Rab proteins are equally expressed in polarized and nonpolarized cells, Rab17 and Rab18 show epithelial cell specificity...
  69. ncbi Calcium signalling in Arabidopsis thaliana responding to drought and salinity
    H Knight
    Department of Plant Sciences, University of Oxford, United Kingdom
    Plant J 12:1067-78. 1997
    ..encodes delta(1)-pyrroline-5-carboxylate synthetase (P5CS), the first enzyme of the proline biosynthesis pathway, rab18 and Iti78 which both encode proteins of unknown function, was induced by mannitol and salt treatments...
  70. ncbi Cloning of Rab GTPases expressed in human skeletal muscle: studies in insulin-resistant subjects
    S Bao
    Department of Medicine, Medical University of South Carolina, Ralph H Johnson Veteran Affairs Medical Center, Charleston 29425, USA
    Horm Metab Res 30:656-62. 1998
    ..Multiple Rab isoforms including Rab1A, Rab4A, Rab5B, Rab7, Rab8, Rab10, Rab12A, Rab13, Rab18, Rab21, and Rab22 mRNA were found to be expressed in human skeletal muscle...
  71. ncbi An Arabidopsis mutant with deregulated ABA gene expression: implications for negative regulator function
    R Foster
    Laboratory for Plant Molecular Biology, Rockefeller University, New York, NY 10021, USA
    Plant J 17:363-72. 1999
    ..Levels of kin2, cor47 and rab18 expression in ade1 plants are also enhanced and prolonged indicating that the molecular mechanism(s) altered in ..
  72. ncbi Induction of RAB18 gene expression and activation of K+ outward rectifying channels depend on an extracellular perception of ABA in Arabidopsis thaliana suspension cells
    E Jeannette
    Laboratoire de Physiologie du Développement des Plantes, UMR CNRS 7632, Université Pierre et Marie Curie Paris VI France
    Plant J 18:13-22. 1999
    ..We show that purified ABA-BSA conjugate is able to trigger RAB18 gene expression and that this response is strictly due to the natural (+)-ABA enantiomer...
  73. ncbi Isolation and characterisation of the human rab18 gene after stimulation of endothelial cells with histamine
    U Schafer
    Biochemical and Experimental Division, II Department of Surgery, University of Cologne, Ostmerheimer Str 200, 51109, Cologne, Germany
    FEBS Lett 466:148-54. 2000
    Here we report the isolation of a cDNA encoding the complete human rab18 protein from histamine-stimulated endothelial cells using differential display...
  74. ncbi Purification of recombinant Arabidopsis thaliana dehydrins by metal ion affinity chromatography
    J Svensson
    Department of Plant Biology, Swedish University of Agricultural Sciences, Uppsala, S 750 07, Sweden
    Protein Expr Purif 20:169-78. 2000
    ..The cDNAs corresponding to the four dehydrin genes RAB18, LTI29, LTI30, and COR47 were inserted into a bacterial expression vector under an isopropyl beta-d-..
  75. ncbi Stress-induced accumulation and tissue-specific localization of dehydrins in Arabidopsis thaliana
    M Nylander
    Department of Plant Biology, Uppsala Genetic Center, Swedish University of Agricultural Sciences
    Plant Mol Biol 45:263-79. 2001
    Stress-induced accumulation of five (COR47, LTI29, ERD14, LTI30 and RAB18) and tissue localization of four (LTI29, ERD14, LTI30 and RAB18) dehydrins in Arabidopsis were characterized immunologically with protein-specific antibodies...
  76. ncbi Synaptotagmin-like protein 5: a novel Rab27A effector with C-terminal tandem C2 domains
    Taruho S Kuroda
    Fukuda Initiative Research Unit, RIKEN The Institute of Physical and Chemical Research, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Biochem Biophys Res Commun 293:899-906. 2002
    ..in intact cells, but not with other Rabs tested (Rab1, Rab2, Rab4A, Rab5A, Rab7, Rab8, Rab9, Rab10, Rab11A, Rab17, Rab18, Rab20, Rab22, Rab23, Rab25, Rab28, and Rab37)...
  77. ncbi Effects of phosphate deficiency and sugars on expression of rab18 in Arabidopsis: hexokinase-dependent and okadaic acid-sensitive transduction of the sugar signal
    Iwona Ciereszko
    Department of Plant Physiology, Umea Plant Science Centre, Umea University, 901 87 Umea, Sweden
    Biochim Biophys Acta 1579:43-9. 2002
    The lack of phosphorus in the nutrient medium increased the expression of rab18, an abscisic acid (ABA)-responsive gene, in leaves of Arabidopsis thaliana...
  78. ncbi Structural determinants of Rab and Rab Escort Protein interaction: Rab family motifs define a conserved binding surface
    Jose B Pereira-Leal
    Cell and Molecular Biology Section, Division of Biomedical Sciences, Faculty of Medicine, Imperial College, Sir Alexander Fleming Building, Exhibition Road, London SW7 2AZ, UK
    Biochem Biophys Res Commun 301:92-7. 2003
    ..These results support the hypothesis that Rabs bind REP via conserved RabF motifs and provide a molecular explanation for the preferential recognition of the GDP-bound conformation of Rab by REP...
  79. ncbi The Arabidopsis thaliana homeobox gene ATHB5 is a potential regulator of abscisic acid responsiveness in developing seedlings
    Henrik Johannesson
    Evolutionary Biology Center, Department of Physiological Botany, Villavagen 6, 75236 Uppsala, Sweden
    Plant Mol Biol 51:719-29. 2003
    ..Consistent with this finding we demonstrate in northern blot experiments that the ABA-responsive gene RAB18 is hyperinduced by ABA in transgenic overexpressor lines as compared to the wild type...
  80. ncbi Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries
    Uta Behrends
    Kinderklinik, Hämatologie Onkologie, Technische Universitat, Munchen, Germany
    Int J Cancer 106:244-51. 2003
    ..by 3 novel genes, genes of unknown function (KIAA0445, KIAA1853, KIAA0665, FLJ13942, HSPC213), a proto-oncogene (rab18), candidate tumor suppressor genes (BAP1, PRDM13) and genes encoding a motor protein (kinesin-2), a histone (H2A1...
  81. ncbi Stress memory in plants: a negative regulation of stomatal response and transient induction of rd22 gene to light in abscisic acid-entrained Arabidopsis plants
    Chang Hyo Goh
    Division of Molecular and Life Science, Pohang University of Science and Technology, San 31, Hyoja Dong, Nam Gu, Pohang, Kyungbuk 790 784, Korea
    Plant J 36:240-55. 2003
    ..These transient effects were also observed in kin1, rab18, and rd29B...
  82. ncbi Beta-amino-butyric acid-induced resistance against necrotrophic pathogens is based on ABA-dependent priming for callose
    Jurriaan Ton
    Laboratory of Biochemistry and Molecular Biology, Department of Science, Institute of Botany, University of Neuchatel, Rue Emile Argand 9, PO Box 2, CH 2007 Neuchatel, Switzerland
    Plant J 38:119-30. 2004
    ..the expression of BABA-induced resistance was not associated with enhanced transcription of the ABA-inducible RAB18 gene, application of ABA mimicked the effect of BABA on the level of callose accumulation and resistance...
  83. ncbi Overexpression of multiple dehydrin genes enhances tolerance to freezing stress in Arabidopsis
    Tuula Puhakainen
    Genetics, Department of Biological and Environmental Sciences, Viikki Biocenter, P O Box 56, FIN 00014, University of Helsinki, Finland
    Plant Mol Biol 54:743-53. 2004
    ..Chimeric double constructs for expression of RAB18 and COR47 (pTP9) or LTI29 and LTI30 (pTP10) were made by fusing the coding sequences of the respective DHN genes ..
  84. ncbi Distribution of Rab GTPases in mouse kidney and comparison with vacuolar H+-ATPase
    Lisa M Curtis
    Department of Medicine, University of Florida, Gainesville, Florida, USA
    Nephron Physiol 100:p31-42. 2005
    ..Although the proteins involved in regulated V-ATPase traffic are largely unknown, Rab GTPases have a central role in the traffic and recycling of other membrane proteins...
  85. ncbi Analysis of Rab18 and a new golgin in the secretory pathway
    M M Malagon
    Department of Cell Biology, Physiology, and Immunology, University of Cordoba, Spain
    Ann N Y Acad Sci 1040:137-9. 2005
    ..Both genes, Rab18 and a novel member of the golgin family of proteins, are ubiquitously expressed in endocrine and nonendocrine ..
  86. ncbi Arabidopsis ERF4 is a transcriptional repressor capable of modulating ethylene and abscisic acid responses
    Zhen Yang
    Department of Biology, West Virginia University, Morgantown, WV 26506, USA
    Plant Mol Biol 58:585-96. 2005
    ..The expression of the ABA responsive genes, ABI2, rd29B and rab18, was decreased in the 35S:AtERF4-GFP transgenic plants...
  87. pmc Ethylene inhibits abscisic acid-induced stomatal closure in Arabidopsis
    Yoko Tanaka
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Kashiwanoha, Kashiwa, Chiba 277 8562, Japan
    Plant Physiol 138:2337-43. 2005
    ..Moreover, expression of the ABA-induced gene RAB18 was reduced following ACC application...
  88. ncbi Cloning and characterization of a novel splice variant of human Rab18 gene (RAB18)
    Tonghai Dou
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China
    DNA Seq 16:230-4. 2005
    ..To date, 60 distinct human RAB proteins have been identified. RAB18 gene is discovered from endothelial cells. Its function is considered as endosomes and plasma membrane recycling...
  89. ncbi Dynamic histone acetylation of late embryonic genes during seed germination
    Helen H Tai
    Canadian Forest Service, Natural Resources Canada, P O Box 4000, E3B 5P7, Fredericton, NB, Canada
    Plant Mol Biol 59:909-25. 2005
    ..Eight TSA-up-regulated genes were selected for further analysis - RAB18, RD29B, ATEM1, HSP70 and four late embryogenesis abundant protein genes (LEA)...
  90. pmc Induction of abscisic acid-regulated gene expression by diacylglycerol pyrophosphate involves Ca2+ and anion currents in Arabidopsis suspension cells
    Christine Zalejski
    Université Pierre et Marie Curie Paris 6 and Centre National de la Recherche Scientifique, FRE 2846, Physiologie Cellulaire et Moléculaire des Plantes, F 94200 Ivry sur Seine, France
    Plant Physiol 141:1555-62. 2006
    ..At5g06760, LTI30, RD29A, and RAB18 were stimulated by ABA and also specifically expressed in DGPP-treated cells...
  91. ncbi Recruitment of TIP47 to lipid droplets is controlled by the putative hydrophobic cleft
    Yuki Ohsaki
    Department of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, Japan
    Biochem Biophys Res Commun 347:279-87. 2006
    ..Consistent with this, overexpression of Rab18 decreased ADRP, but not TIP47, from LDs, and TIP47 did not displace pre-existing ADRP from LDs...
  92. ncbi The phs1-3 mutation in a putative dual-specificity protein tyrosine phosphatase gene provokes hypersensitive responses to abscisic acid in Arabidopsis thaliana
    Anne Laure Quettier
    Universite Pierre et Marie Curie Paris 6, FRE 2846, PCMP, Ivry sur Seine, F 94200, France
    Plant J 47:711-9. 2006
    ..The upregulation of two ABA-induced genes (At5g06760, RAB18) and the downregulation of two ABA-repressed genes (AtCLC-A, ACL) are enhanced in the phs1-3 mutant compared with ..
  93. ncbi AtGRP7 is involved in the regulation of abscisic acid and stress responses in Arabidopsis
    Shuqing Cao
    School of Biotechnology and Food Engineering, Hefei University of Technology, Hefei, Anhui, China
    Cell Mol Biol Lett 11:526-35. 2006
    ..mutant plants accumulated significantly higher transcript levels of two ABA-and stress-inducible genes, RD29A and RAB18, compared with the wild-type plants...
  94. ncbi Rab18 inhibits secretory activity in neuroendocrine cells by interacting with secretory granules
    Rafael Vazquez-Martinez
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, 14014 Cordoba, Spain
    Traffic 8:867-82. 2007
    ..In this study, we identified Rab18 as a new inhibitory player of the secretory pathway in neuroendocrine cells...
  95. ncbi All-trans-retinol generated by rhodopsin photobleaching induces rapid recruitment of TIP47 to lipid droplets in the retinal pigment epithelium
    Eiko Tsuiki
    Department of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Invest Ophthalmol Vis Sci 48:2858-67. 2007
    ..To investigate the effect of light stimulation on lipid droplets (LDs) and LD proteins in the retinal pigment epithelium (RPE)...
  96. ncbi SAZ, a new SUPERMAN-like protein, negatively regulates a subset of ABA-responsive genes in Arabidopsis
    Chang Jie Jiang
    Plant Disease Resistance Research Unit, Division of Plant Science, National Institute of Agrobiological Sciences, 2 1 2 Kannondai, Tsukuba, Ibaraki, Japan
    Mol Genet Genomics 279:183-92. 2008
    ..knockdown of SAZ (SAZ-kd) resulted in elevated expression of the drought- and ABA-responsive genes rd29B and rab18 under unstressed conditions, and it enhanced the response of these genes to drought and ABA treatment...
  97. doi Onset of lactation in the bovine mammary gland: gene expression profiling indicates a strong inhibition of gene expression in cell proliferation
    Kiera A Finucane
    Lactation and Mammary Gland Biology Group, Department of Animal Science, University of Vermont, Burlington, VT 05405, USA
    Funct Integr Genomics 8:251-64. 2008
    ..and cell signaling factors (protein p8, Rab18, etc.)...
  98. doi Rab18 is reduced in pituitary tumors causing acromegaly and its overexpression reverts growth hormone hypersecretion
    Rafael Vazquez-Martinez
    Department of Cell Biology, Physiology, and Immunology, Campus de Rabanales Edificio Severo Ochoa, University of Cordoba, Cordoba, Spain
    J Clin Endocrinol Metab 93:2269-76. 2008
    ..Alterations of these GTPases and their associated proteins are emerging as the underlying cause for several human diseases involving dysregulated secretory activities...
  99. doi Characterization of Rab18, a lipid droplet-associated small GTPase
    Sally Martin
    Institute for Molecular Bioscience and Centre for Microscopy and Microanalysis, University of Queensland, Brisbane, Queensland, Australia
    Methods Enzymol 438:109-29. 2008
    ..Here we describe the techniques that we used to characterize the regulated association of Rab18 with the surface of lipid droplets...
  100. doi Overexpression of a rice OsDREB1F gene increases salt, drought, and low temperature tolerance in both Arabidopsis and rice
    Qiuyun Wang
    State Key Laboratory of Plant Genomics and National Centre for Plant Gene Research Beijing, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China
    Plant Mol Biol 67:589-602. 2008
    ..activating the expression of COR genes which contain DRE/CRT element in their upstream promoter regions, the expression of rd29B and RAB18 genes were also activated, suggested that OsDREB1F may also participate in ABA-dependent pathway.
  101. doi Overexpression of Arabidopsis ZEP enhances tolerance to osmotic stress
    Hee Yeon Park
    Department of Biological Sciences, Pusan National University, San 30, Jangjeon Dong, Geumjeong Gu, Busan 609 735, Republic of Korea
    Biochem Biophys Res Commun 375:80-5. 2008
    ..plants also exhibited much higher expression of the endogenous stress-responsive genes RD29A and Rab18 than wild-type plants under salt stress...