PTX3

Summary

Gene Symbol: PTX3
Description: pentraxin 3
Alias: TNFAIP5, TSG-14, pentraxin-related protein PTX3, TNF alpha-induced protein 5, long pentraxin 3, tumor necrosis factor alpha-induced protein 5, tumor necrosis factor-inducible gene 14 protein, tumor necrosis factor-inducible protein TSG-14
Species: human

Top Publications

  1. ncbi TSG-14, a tumor necrosis factor- and IL-1-inducible protein, is a novel member of the pentaxin family of acute phase proteins
    G W Lee
    Department of Microbiology, New York University Medical Center, NY 10016
    J Immunol 150:1804-12. 1993
  2. ncbi Long pentraxin 3 in pulmonary infection and acute lung injury
    Xiaolin He
    Thoracic Surgery Research Laboratory, University Health Network Toronto General Research Institute, Department of Surgery, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Am J Physiol Lung Cell Mol Physiol 292:L1039-49. 2007
  3. pmc Synergy between ficolin-2 and pentraxin 3 boosts innate immune recognition and complement deposition
    Ying Jie Ma
    Laboratory of Molecular Medicine, Department of Clinical Immunology, Section 7631, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen 2100, Denmark
    J Biol Chem 284:28263-75. 2009
  4. pmc The angiogenic inhibitor long pentraxin PTX3 forms an asymmetric octamer with two binding sites for FGF2
    Antonio Inforzato
    Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, United Kingdom
    J Biol Chem 285:17681-92. 2010
  5. ncbi Production of the long pentraxin PTX3 in advanced atherosclerotic plaques
    Michael S Rolph
    Heart Research Institute, Camperdown, New South Wales, Australia
    Arterioscler Thromb Vasc Biol 22:e10-4. 2002
  6. pmc Associations of pentraxin 3 with cardiovascular disease and all-cause death: the Cardiovascular Health Study
    Nancy Swords Jenny
    Department of Pathology, University of Vermont, Colchester, VT 05446, USA
    Arterioscler Thromb Vasc Biol 29:594-9. 2009
  7. pmc Soluble TWEAK and PTX3 in nondialysis CKD patients: impact on endothelial dysfunction and cardiovascular outcomes
    Mahmut Ilker Yilmaz
    Department of Nephrology, Gu lhane School of Medicine, Ankara, Turkey
    Clin J Am Soc Nephrol 6:785-92. 2011
  8. doi The long pentraxin PTX3 as a correlate of cancer-related inflammation and prognosis of malignancy in gliomas
    Marco Locatelli
    Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    J Neuroimmunol 260:99-106. 2013
  9. doi Genetic variation in pentraxin (PTX) 3 gene associates with PTX3 production and fertility in women
    Linda May
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Biol Reprod 82:299-304. 2010
  10. doi The soluble pattern recognition receptor pentraxin-3 in innate immunity, inflammation and fertility
    Cecilia Garlanda
    Istituto Clinico Humanitas IRCCS, Rozzano, Italy
    J Reprod Immunol 83:128-33. 2009

Research Grants

  1. Domains of Inflammation and Risk of Dementia
    Annette L Fitzpatrick; Fiscal Year: 2013
  2. James T Handa; Fiscal Year: 2015
  3. Anti-angiogenesis of HC-HA Covalent Complex and PTX3 Purified from Fetal Membrane
    Scheffer C G Tseng; Fiscal Year: 2011
  4. LH ACTION IN OVARIAN CELL DIFFERENTIATION
    JoAnne S Richards; Fiscal Year: 2013
  5. Regulation of Key Processes in Oocyte Biology
    Martin Matzuk; Fiscal Year: 2007
  6. EX VIVO EXPANSION OF RPE CELLS FOR TRANSPLANTATION
    Scheffer Tseng; Fiscal Year: 2005
  7. DEVELOPMENT OF SUTURELESS AMNIOTIC MEMBRANE GRAFT
    Scheffer Tseng; Fiscal Year: 2007
  8. ANTI-SCARRING AND ANTI-INFLAMMATORY EFFECTS OF AMNIOTIC MEMBRANE EXTRACTS
    Scheffer Tseng; Fiscal Year: 2006
  9. TRANSPLANTATION OF EXPANDED LIMBAL EPITHELIAL STEM CELLS
    Scheffer Tseng; Fiscal Year: 2007
  10. Post-transcriptional gene regulation in the ovary
    Lane Christenson; Fiscal Year: 2007

Detail Information

Publications206 found, 100 shown here

  1. ncbi TSG-14, a tumor necrosis factor- and IL-1-inducible protein, is a novel member of the pentaxin family of acute phase proteins
    G W Lee
    Department of Microbiology, New York University Medical Center, NY 10016
    J Immunol 150:1804-12. 1993
    ..Our data strongly suggest that TSG-14 is a novel member of the pentaxin family of acute phase proteins...
  2. ncbi Long pentraxin 3 in pulmonary infection and acute lung injury
    Xiaolin He
    Thoracic Surgery Research Laboratory, University Health Network Toronto General Research Institute, Department of Surgery, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Am J Physiol Lung Cell Mol Physiol 292:L1039-49. 2007
    b>Long pentraxin 3 (PTX3) is a newly discovered acute phase protein produced at the sites of infection and inflammation by tissue cells, macrophages, monocytes, and dendritic cells...
  3. pmc Synergy between ficolin-2 and pentraxin 3 boosts innate immune recognition and complement deposition
    Ying Jie Ma
    Laboratory of Molecular Medicine, Department of Clinical Immunology, Section 7631, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen 2100, Denmark
    J Biol Chem 284:28263-75. 2009
    The long pentraxin 3 (PTX3) is a multifunctional soluble pattern recognition molecule that is crucial in innate immune protection against opportunistic fungal pathogens such as Aspergillus fumigatus...
  4. pmc The angiogenic inhibitor long pentraxin PTX3 forms an asymmetric octamer with two binding sites for FGF2
    Antonio Inforzato
    Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, United Kingdom
    J Biol Chem 285:17681-92. 2010
    The inflammation-associated long pentraxin PTX3 plays key roles in innate immunity, female fertility, and vascular biology (e.g. it inhibits FGF2 (fibroblast growth factor 2)-mediated angiogenesis)...
  5. ncbi Production of the long pentraxin PTX3 in advanced atherosclerotic plaques
    Michael S Rolph
    Heart Research Institute, Camperdown, New South Wales, Australia
    Arterioscler Thromb Vasc Biol 22:e10-4. 2002
    ..The long pentraxin family member, pentraxin 3 (PTX3), was recently described...
  6. pmc Associations of pentraxin 3 with cardiovascular disease and all-cause death: the Cardiovascular Health Study
    Nancy Swords Jenny
    Department of Pathology, University of Vermont, Colchester, VT 05446, USA
    Arterioscler Thromb Vasc Biol 29:594-9. 2009
    We examined associations of pentraxin 3 (PTX3), a vascular inflammation marker, with incident cardiovascular disease (CVD) and all-cause death.
  7. pmc Soluble TWEAK and PTX3 in nondialysis CKD patients: impact on endothelial dysfunction and cardiovascular outcomes
    Mahmut Ilker Yilmaz
    Department of Nephrology, Gu lhane School of Medicine, Ankara, Turkey
    Clin J Am Soc Nephrol 6:785-92. 2011
    ..Soluble TNF-like weak inducer of apoptosis (sTWEAK) and long pentraxin 3 (PTX3) are predictors of mortality in dialysis patients and determinants of endothelial dysfunction...
  8. doi The long pentraxin PTX3 as a correlate of cancer-related inflammation and prognosis of malignancy in gliomas
    Marco Locatelli
    Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    J Neuroimmunol 260:99-106. 2013
    Inflammation is a component of glioma microenvironment. PTX3 is a component of the humoral arm of innate immunity and a candidate marker of inflammation...
  9. doi Genetic variation in pentraxin (PTX) 3 gene associates with PTX3 production and fertility in women
    Linda May
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Biol Reprod 82:299-304. 2010
    Pentraxin 3 (PTX3) plays an important role in innate immune responses and in female fertility, as discovered with studies in mice. However, the role of PTX3 in human fertility is unknown...
  10. doi The soluble pattern recognition receptor pentraxin-3 in innate immunity, inflammation and fertility
    Cecilia Garlanda
    Istituto Clinico Humanitas IRCCS, Rozzano, Italy
    J Reprod Immunol 83:128-33. 2009
    ..They play key roles as effectors and modulators of innate resistance and inflammation. The long pentraxin PTX3 represents a prototype humoral effector molecule...
  11. doi Increased serum pentraxin 3 in patients with systemic sclerosis
    Yohei Iwata
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Rheumatol 36:976-83. 2009
    To determine serum concentrations of pentraxin 3 (PTX3) and its clinical associations in patients with systemic sclerosis (SSc).
  12. ncbi Establishment of a high sensitivity plasma assay for human pentraxin3 as a marker for unstable angina pectoris
    Kenji Inoue
    Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, 4 6 1, Komaba, Meguro, Tokyo, 153 8904, Japan
    Arterioscler Thromb Vasc Biol 27:161-7. 2007
    Plasma pentraxin 3 (PTX3) levels are increased in patients with acute myocardial infarction, yet its involvement in unstable angina pectoris (UAP) remains unclear...
  13. doi Determination of physiological plasma pentraxin 3 (PTX3) levels in healthy populations
    Kazumi Yamasaki
    Narao Hospital, Nagasaki, Japan
    Clin Chem Lab Med 47:471-7. 2009
    The aim of this study was to evaluate the distribution of pentraxin 3 (PTX3) values in healthy subjects and to characterize its relationship with gender, age, body mass index (BMI), lipid profile, and blood sugar levels.
  14. doi Long pentraxin PTX3 deficiency worsens LPS-induced acute lung injury
    Bing Han
    Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, Toronto, ON, Canada
    Intensive Care Med 37:334-42. 2011
    Long pentraxin PTX3 is an inflammatory mediator and a component of the humoral arm of innate immunity...
  15. doi Long pentraxin-3 as an epithelial-stromal fibroblast growth factor-targeting inhibitor in prostate cancer
    Roberto Ronca
    Department of Molecular and Translational Medicine, School of Medicine, University of Brescia, Brescia, Italy
    J Pathol 230:228-38. 2013
    ..The soluble pattern recognition receptor long pentraxin-3 (PTX3) acts as a natural FGF antagonist that binds FGF2 and FGF8b via its N-terminal domain...
  16. pmc Novel links between the long pentraxin 3, endothelial dysfunction, and albuminuria in early and advanced chronic kidney disease
    Mohamed E Suliman
    Department of Clinical Science, Intervention, and Technology, Karolinska Institutet, Divisions of Renal Medicine and Baxter Novum, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Clin J Am Soc Nephrol 3:976-85. 2008
    ..Albuminuria and inflammation predict cardiovascular events. Pentraxin 3, an inflammatory mediator produced by, among others, endothelial cells, may have a role in atherogenesis...
  17. pmc Inflammation and thrombosis in essential thrombocythemia and polycythemia vera: different role of C-reactive protein and pentraxin 3
    Tiziano Barbui
    Hematology Department, Ospedali Riuniti, Largo Barozzi 1, 24128 Bergamo, Italy
    Haematologica 96:315-8. 2011
    ....
  18. doi Early and transient release of leukocyte pentraxin 3 during acute myocardial infarction
    Norma Maugeri
    Istituto Scientifico San Raffaele and Università Vita Salute San Raffaele, Milan 20132, Italy
    J Immunol 187:970-9. 2011
    Pentraxin 3 (PTX3) plays cardioprotective and anti-atherogenic roles in murine models. PTX3 blood levels raise during early acute myocardial infarction (AMI)...
  19. ncbi PTX3, A prototypical long pentraxin, is an early indicator of acute myocardial infarction in humans
    G Peri
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Circulation 102:636-41. 2000
    Inflammation is an important component of ischemic heart disease. PTX3 is a long pentraxin whose expression is induced by cytokines in endothelial cells, mononuclear phagocytes, and myocardium...
  20. ncbi PTX3 interacts with inter-alpha-trypsin inhibitor: implications for hyaluronan organization and cumulus oophorus expansion
    Laura Scarchilli
    Department of Public Health and Cell Biology, University of Rome Tor Vergata, 00133 Rome
    J Biol Chem 282:30161-70. 2007
    Pentraxin 3 (PTX3) and heavy chains (HCs) of inter-alpha-trypsin inhibitor (IalphaI) are essential for hyaluronan (HA) organization within the extracellular matrix of the cumulus oophorus, which is critical for in vivo oocyte ..
  21. doi Pentraxins in innate immunity: lessons from PTX3
    Livija Deban
    Istituto Clinico Humanitas IRCCS, Via Manzoni 113, 20089 Rozzano, Milan, Italy
    Cell Tissue Res 343:237-49. 2011
    ..The long pentraxin PTX3 is produced by innate immunity cells (e.g...
  22. doi Pentraxin-3 is a novel biomarker of lung carcinoma
    Eleftherios P Diamandis
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Clin Cancer Res 17:2395-9. 2011
    Our objective was to validate the performance of three new candidate lung cancer biomarkers, pentraxin-3 (PTX3), human kallikrein 11 (KLK11), and progranulin.
  23. ncbi Complexity and complementarity of outer membrane protein A recognition by cellular and humoral innate immunity receptors
    Pascale Jeannin
    Centre d Immunologie Pierre Fabre, 5 Avenue Napoleon III, 74164 Saint Julien en Genevois, France
    Immunity 22:551-60. 2005
    ..The TLR2-activated functional program includes production of the long pentraxin PTX3, a soluble pattern recognition receptor involved in resistance against diverse pathogens...
  24. ncbi Pentraxin 3 inhibits fibroblast growth factor 2-dependent activation of smooth muscle cells in vitro and neointima formation in vivo
    Maura Camozzi
    Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, 25123 Brescia, Italy
    Arterioscler Thromb Vasc Biol 25:1837-42. 2005
    ..Long-pentraxin 3 (PTX3) is a soluble pattern recognition receptor with non-redundant functions in inflammation and innate immunity...
  25. ncbi Structure and function of the long pentraxin PTX3 glycosidic moiety: fine-tuning of the interaction with C1q and complement activation
    Antonio Inforzato
    Department of Biology, University Tor Vergata, Rome, Italy
    Biochemistry 45:11540-51. 2006
    The prototypic long pentraxin PTX3 is a unique fluid-phase pattern recognition receptor that plays a nonredundant role in innate immunity and female fertility...
  26. ncbi DC-SIGN (CD209), pentraxin 3 and vitamin D receptor gene variants associate with pulmonary tuberculosis risk in West Africans
    R Olesen
    MRC Laboratories, Banjul, The Gambia
    Genes Immun 8:456-67. 2007
    We investigated the role of DC-SIGN (CD209), long pentraxin 3 (PTX3) and vitamin D receptor (VDR) gene single nucleotide polymorphisms (SNPs) in susceptibility to pulmonary tuberculosis (TB) in 321 TB cases and 347 healthy controls from ..
  27. ncbi Complement dependent amplification of the innate response to a cognate microbial ligand by the long pentraxin PTX3
    Alessia Cotena
    Istituto Clinico Humanitas, Rozzano Milan, Italy
    J Immunol 179:6311-7. 2007
    The long pentraxin PTX3 is a fluid-phase pattern recognition receptor, which plays a nonredundant role in resistance against selected pathogens...
  28. ncbi Antiviral activity of the long chain pentraxin PTX3 against influenza viruses
    Patrick C Reading
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
    J Immunol 180:3391-8. 2008
    ..In this study, we identify the long pentraxin PTX3 as a potent innate inhibitor of influenza viruses both in vitro and in vivo...
  29. ncbi Binding of the long pentraxin PTX3 to factor H: interacting domains and function in the regulation of complement activation
    Livija Deban
    Laboratory for Immunology and Inflammation, Instituto di Ricerca e Cura a Carattere Scientifico Istituto Clinico Humanitas, Rozzano, Italy
    J Immunol 181:8433-40. 2008
    The long pentraxin PTX3 is a multifunctional soluble molecule involved in inflammation and innate immunity...
  30. doi M-ficolin interacts with the long pentraxin PTX3: a novel case of cross-talk between soluble pattern-recognition molecules
    Evelyne Gout
    Commissariat a l Energie Atomique, Institut de Biologie Structurale Jean Pierre Ebel, 38027 Grenoble, France
    J Immunol 186:5815-22. 2011
    ..The interaction of M-ficolin with the long pentraxin pentraxin 3 (PTX3) has been characterized using surface plasmon resonance spectroscopy and electron microscopy...
  31. doi Associations of plasma pentraxin 3 and monocyte chemoattractant protein-1 concentrations with cardiovascular disease in patients with chronic kidney disease
    Keiko Nishi
    Division of Circulatory and Body Fluid Regulation, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
    Ren Fail 33:398-404. 2011
    Both pentraxin 3 (PTX3) and monocyte chemoattractant protein-1 (MCP-1) are mediators of inflammation...
  32. doi High plasma level of long Pentraxin 3 is associated with insulin resistance in women with polycystic ovary syndrome
    Aydogan Aydogdu
    Department of Endocrinology and Metabolism, Gulhane School of Medicine, Etlik, Ankara, Turkey
    Gynecol Endocrinol 28:722-5. 2012
    ..Pentraxin 3 (PTX3) is an inflammatory mediator synthesized in a variety of cells and tissues including heart, vascular endothelial ..
  33. doi Plasma pentraxin-3 levels are associated with coronary plaque vulnerability and are decreased by statin
    Atsushi Iwata
    Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan
    Coron Artery Dis 23:315-21. 2012
    Pentraxin 3 (PTX3) is a novel candidate immunoinflammatory marker that has been reported to be associated with cardiometabolic risk factors and to predict adverse outcomes in patients with coronary artery disease...
  34. ncbi Elevated maternal levels of the long pentraxin 3 (PTX3) in preeclampsia and intrauterine growth restriction
    Irene Cetin
    Institute of Obstetrics and Gynecology, Fondazione IRCCS Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Am J Obstet Gynecol 194:1347-53. 2006
    ..We investigated pentraxin 3 levels in preeclampsia and intrauterine growth restriction, pregnancy conditions related to altered placentation...
  35. ncbi Selective induction of pentraxin 3, a soluble innate immune pattern recognition receptor, in infectious episodes in patients with haematological malignancy
    Basel K al-Ramadi
    Department of Medical Microbiology, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
    Clin Immunol 112:221-4. 2004
    ..P component, collectively known as the classical short pentraxins, and the more recently discovered pentraxin 3 (PTX3), a member of the closely related subfamily of the long pentraxins...
  36. ncbi Innate responses to Aspergillus: role of C1q and pentraxin 3 in nasal polyposis
    Paramita Baruah
    Cancer Immunotherapy and Gene Therapy Program, Clinical Immunology Unit, H San Raffaele Scientific Institute, Via Olgettina 58, Milano, Italy
    Am J Rhinol 21:224-30. 2007
    Pentraxin 3 (PTX3) and complement component C1q are humoral factors of innate immunity, produced at sites of inflammation, and are essential in immune defense against several microbes such as Aspergillus, which is commonly implicated in ..
  37. pmc Systemic sclerosis-endothelial cell antiangiogenic pentraxin 3 and matrix metalloprotease 12 control human breast cancer tumor vascularization and development in mice
    Francesca Margheri
    Department of Experimental Pathology and Oncology, University of Florence, 50134 Florence, Italy
    Neoplasia 11:1106-15. 2009
    We have previously shown that endothelial cell matrix metalloprotease 12 (MMP12) and pentraxin 3 (PTX3) overproduction is the main alteration accounting for reduced proneness to angiogenesis in systemic sclerosis (SSc)...
  38. ncbi Interleukin-1-inducible genes in endothelial cells. Cloning of a new gene related to C-reactive protein and serum amyloid P component
    F Breviario
    Istituto Ricerche Farmacologiche Mario Negri, Milano, Italy
    J Biol Chem 267:22190-7. 1992
    ..endothelial cells exposed for 1 h to interleukin-1 beta (IL-1 beta) has led to the identification of a novel gene (PTX3) related to pentaxins (C-reactive protein and serum amyloid P component in man), a subclass of acute phase proteins...
  39. pmc A novel secretory tumor necrosis factor-inducible protein (TSG-6) is a member of the family of hyaluronate binding proteins, closely related to the adhesion receptor CD44
    T H Lee
    Department of Microbiology, New York University Medical Center, New York 10016
    J Cell Biol 116:545-57. 1992
    ....
  40. ncbi Inducible expression of PTX3, a new member of the pentraxin family, in human mononuclear phagocytes
    V V Alles
    Laboratory of Immunology, Istituto di Ricerche Farmacologiche, Mario Negri, Milano, Italy
    Blood 84:3483-93. 1994
    ..b>PTX3 was recently cloned as an interleukin-1 (IL-1)-inducible gene in endothelial cells, with structural similarities to ..
  41. pmc Expression of a long pentraxin, PTX3, by monocytes exposed to the mycobacterial cell wall component lipoarabinomannan
    V Vouret-Craviari
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Infect Immun 65:1345-50. 1997
    b>PTX3 is a prototypic long pentraxin composed of a C-terminal domain similar to those of classical pentraxins (e.g., C reactive protein) and an unrelated N-terminal portion...
  42. ncbi PTX3 in small-vessel vasculitides: an independent indicator of disease activity produced at sites of inflammation
    F Fazzini
    Istituto Scientifico H San Raffaele and Università, Milan, Italy
    Arthritis Rheum 44:2841-50. 2001
    To verify whether the prototypical long pentraxin PTX3 represents an indicator of the activity of small-vessel vasculitis.
  43. ncbi Long pentraxin PTX3 upregulates tissue factor expression in human endothelial cells: a novel link between vascular inflammation and clotting activation
    Emanuela Napoleone
    Antonio Taticchi Unit for Atherosclerosis and Thrombosis, Department of Vascular Medicine and Pharmacology, Istituto Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, S Maria Imbaro, Italy
    Arterioscler Thromb Vasc Biol 22:782-7. 2002
    Inflammation is a major contributing factor to atherosclerotic plaque development and ischemic heart disease. PTX3 is a long pentraxin that was recently found to be increased in patients with acute myocardial infarction...
  44. ncbi The long pentraxin PTX3 is synthesized in IgA glomerulonephritis and activates mesangial cells
    Benedetta Bussolati
    Cattedra di Nefrologia, Dipartimento di Medicina Interna, Università di Torino and Ospedale S Giovanni Battista, Torino, Italy
    J Immunol 170:1466-72. 2003
    The long pentraxin PTX3 has been recently involved in amplification of the inflammatory reactions and regulation of innate immunity. In the present study we evaluated the expression and role of PTX3 in glomerular inflammation...
  45. ncbi Characterization of the long pentraxin PTX3 as a TNFalpha-induced secreted protein of adipose cells
    Anissa Abderrahim-Ferkoune
    Institute of Signaling, Developmental Biology and Cancer Research, Centre de Biochimie, UMR 6543 CNRS, Faculte des Sciences, Parc Valrose, 06108 Nice Cedex 2, France
    J Lipid Res 44:994-1000. 2003
    ..are regulated by fatty acids in preadipocytes, we performed a substractive hybridization screening and identified PTX3, a protein of the pentraxin family...
  46. ncbi Pentraxin 3, a non-redundant soluble pattern recognition receptor involved in innate immunity
    Alberto Mantovani
    Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Vaccine 21:S43-7. 2003
    Pentraxin 3 (PTX3) is the first long pentraxin identified...
  47. ncbi Production of the soluble pattern recognition receptor PTX3 by myeloid, but not plasmacytoid, dendritic cells
    Andrea Doni
    Department of Immunology and Cell Biology, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Eur J Immunol 33:2886-93. 2003
    b>PTX3 is a prototypic of long pentraxin consisting of an N-terminal portion coupled to a C-terminal pentraxin domain, the latter related to short pentraxins (C-reactive protein and serum amyloid P component)...
  48. ncbi Differential expression of pentraxin 3 in fibroblasts from patients with major depression
    Richard C Shelton
    Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN 37211, USA
    Neuropsychopharmacology 29:126-32. 2004
    ..included an overexpressed 269 bp sequence tag showing approximately 95% identity with the Homo sapiens long pentraxin 3 (PTX3) gene sequence in the 3' noncoding region. The 269 bp complimentary DNA probe hybridized with the 1...
  49. ncbi Modified atherogenic lipoproteins induce expression of pentraxin-3 by human vascular smooth muscle cells
    Mariam Klouche
    Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Franz Josef Strauss Allee 11 93053 Regensburg, Germany
    Atherosclerosis 175:221-8. 2004
    ..Recently, the acute-phase protein pentraxin-3 (PTX3), which has C-terminal sequence homology with the classic pentraxin C-reactive protein (CRP), was described to be ..
  50. ncbi The pattern recognition receptor PTX3 is recruited at the synapse between dying and dendritic cells, and edits the cross-presentation of self, viral, and tumor antigens
    Paramita Baruah
    Cancer Immunotherapy and Gene Therapy Program, H San Raffaele Institute, Milan, Italy
    Blood 107:151-8. 2006
    ..Here we show that the prototypic long pentraxin PTX3 is specifically recruited at both sides of the phagocytic synapse between dendritic cells (DCs) and dying cells and ..
  51. ncbi TNFalpha-induced long pentraxin PTX3 expression in human lung epithelial cells via JNK
    Bing Han
    Thoracic Surgery Research Laboratory, University Health Network Toronto General Research Institute, Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    J Immunol 175:8303-11. 2005
    b>Long pentraxin 3 (PTX3), an acute-phase protein, is a newly clarified mediator for innate immunity and inflammation. As a soluble pattern recognition receptor, it has a nonredundant role in antifungal infection...
  52. ncbi The tissue pentraxin PTX3 limits C1q-mediated complement activation and phagocytosis of apoptotic cells by dendritic cells
    Paramita Baruah
    Clinical Immunology Unit, H San Raffaele Scientific Institute, Via Olgettina 58, Milano 20132, Italy
    J Leukoc Biol 80:87-95. 2006
    ..The prototypic long PTX, PTX3, and the first component of the classical complement pathway, C1q, are innate opsonins involved in the disposal of ..
  53. ncbi Long pentraxin 3: a marker of inflammation in untreated psoriatic patients
    Valentina Bevelacqua
    Dermathology Unit, AORNAS, Garibaldi Hospital, Catania, Italy
    Int J Mol Med 18:415-23. 2006
    ..and their relationship with inflammatory markers, such as CRP and fibrinogen we have investigated the role of PTX3 in psoriasis...
  54. ncbi Pentraxin 3 is elevated in haemodialysis patients and is associated with cardiovascular disease
    Michael Boehme
    Department of Nephrology and Intensive Care Medicine, Charite, Universitaetsmedizin Berlin, Campus Virchow Klinikum, Berlin
    Nephrol Dial Transplant 22:2224-9. 2007
    ..While elevation of C-reactive protein (CRP) in patients with renal failure and its association with cardiovascular disease is well described, there are no data on pentraxin 3 (PTX3) in this population.
  55. doi Pentraxin 3 and C-reactive protein in severe meningococcal disease
    Tom Sprong
    Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Shock 31:28-32. 2009
    The long pentraxin 3 (PTX3) is an important element of the innate immune system and has potential as a diagnostic tool in inflammatory conditions...
  56. pmc Cell-specific regulation of PTX3 by glucocorticoid hormones in hematopoietic and nonhematopoietic cells
    Andrea Doni
    Istituto Clinico Humanitas, Istituto Di Ricerca Cura a Caratte Re Scientifico, Department of Immunology and Inflammation, Rozzano, Milan, Italy
    J Biol Chem 283:29983-92. 2008
    PTX3 (prototypic long pentraxin 3) is a fluid phase pattern recognition receptor, which plays nonredundant roles in the resistance against diverse pathogens, in the assembly of a hyaluronic acid-rich extracellular matrix, and in female ..
  57. doi Endogenous PTX3 translocates at the membrane of late apoptotic human neutrophils and is involved in their engulfment by macrophages
    S Jaillon
    Institut National de la Sante et de la Recherche Medicale, U564, Angers, France
    Cell Death Differ 16:465-74. 2009
    ..Neutrophils constitutively express the prototypic long pentraxin PTX3 that binds to apoptotic cells and modulates their clearance...
  58. pmc Effect of renin angiotensin system blockade on pentraxin 3 levels in type-2 diabetic patients with proteinuria
    Mahmut Ilker Yilmaz
    Department of Nephrology, Gulhane School of Medicine, Etlik Ankara, Turkey
    Clin J Am Soc Nephrol 4:535-41. 2009
    b>Long pentraxin 3 (PTX3) is a multimeric inflammatory mediator. Increased serum PTX3 levels have been reported among end-stage renal disease patients...
  59. pmc Coregulation in human leukocytes of the long pentraxin PTX3 and TSG-6
    Virginia Maina
    Research Laboratory in Immunology and Inflammation, Istituto Clinico Humanitas IRCCS, Rozzano, Milan, Italy
    J Leukoc Biol 86:123-32. 2009
    The prototypic long PTX3 is a multifunctional protein involved in innate resistance to pathogens and in controlling inflammation...
  60. pmc Pentraxin 3 in amniotic fluid: a novel association with intra-amniotic infection and inflammation
    Laura Cruciani
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
    J Perinat Med 38:161-71. 2010
    Pentraxin 3 (PTX3) is a soluble pattern recognition receptor (PRR) that has an important role in immunoregulation and vascular integrity...
  61. pmc Pentraxin 3 in maternal circulation: an association with preterm labor and preterm PROM, but not with intra-amniotic infection/inflammation
    Laura Cruciani
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 23:1097-105. 2010
    Pentraxin 3 (PTX3) is an acute-phase protein that has an important role in the regulation of the innate immune response...
  62. ncbi Is pentraxin 3 involved in obesity-induced decrease in arterial distensibility?
    Asako Miyaki
    Division of Sports Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    J Atheroscler Thromb 17:278-84. 2010
    ..Pentraxin 3 (PTX3), a recently identified member of the pentraxin family of proteins, is produced in areas of atherosclerosis...
  63. doi PTX3 expression in the heart tissues of patients with myocardial infarction and infectious myocarditis
    Manuela Nebuloni
    Pathology Unit, L Sacco Department of Clinical Sciences, L Sacco Hospital, Universita degli Studi di Milano, Milan, Italy
    Cardiovasc Pathol 20:e27-35. 2011
    The long pentraxin 3 is involved in innate resistance to pathogens, controlling inflammation and extracellular matrix remodeling...
  64. doi Increased levels of serum pentraxin 3, a novel cardiovascular biomarker, in patients with inflammatory rheumatic disease
    Ivana Hollan
    Feiring Heart Clinic, Feiring, and Hospital for Rheumatic Diseases, Lillehammer, Norway
    Arthritis Care Res (Hoboken) 62:378-85. 2010
    Pentraxin 3 (PTX3), a key component of innate immunity, is a strong marker of disease severity in coronary artery disease (CAD)...
  65. pmc PTX3 genetic variations affect the risk of Pseudomonas aeruginosa airway colonization in cystic fibrosis patients
    M Chiarini
    Clinica Pediatrica, Istituto di Medicina Molecolare Angelo Nocivelli, Universita di Brescia, Brescia, Italy
    Genes Immun 11:665-70. 2010
    ..Pentraxin 3 (PTX3) is a gene that encodes the antimicrobial protein, PTX3, which is believed to have an important role in innate ..
  66. doi Cerebrospinal fluid pentraxin 3 early after subarachnoid hemorrhage is associated with vasospasm
    Elisa R Zanier
    Department of Neuroscience, Laboratory of Inflammation and Nervous System Diseases, Mario Negri Institute for Pharmacological Research, via Giuseppe La Masa, 19, 20156 Milan, Italy
    Intensive Care Med 37:302-9. 2011
    To investigate plasma and cerebrospinal fluid (CSF) concentrations of pentraxin 3 (PTX3), a prototypic long pentraxin protein induced by proinflammatory signals, in subarachnoid hemorrhage (SAH), and its relation with SAH-associated ..
  67. pmc Heterocomplexes of mannose-binding lectin and the pentraxins PTX3 or serum amyloid P component trigger cross-activation of the complement system
    Ying Jie Ma
    Laboratory of Molecular Medicine, Department of Clinical Immunology, Sect 7631, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, 2100 Copenhagen, Denmark
    J Biol Chem 286:3405-17. 2011
    The long pentraxin 3 (PTX3), serum amyloid P component (SAP), and C-reactive protein belong to the pentraxin family of pattern recognition molecules involved in tissue homeostasis and innate immunity...
  68. doi The long pentraxin PTX3 at the crossroads between innate immunity and tissue remodelling
    A Inforzato
    Istituto Clinico Humanitas IRCCS, 20089 Rozzano, Italy
    Tissue Antigens 77:271-82. 2011
    ..Pentraxin 3 (PTX3) is the prototypic member of the long pentraxins subfamily...
  69. pmc High plasma level of long pentraxin 3 (PTX3) is associated with fatal disease in bacteremic patients: a prospective cohort study
    Reetta Huttunen
    Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
    PLoS ONE 6:e17653. 2011
    b>Long pentraxin 3 (PTX3) is an acute-phase protein secreted by various cells, including leukocytes and endothelial cells. Like C-reactive protein (CRP), it belongs to the pentraxin superfamily...
  70. doi Long pentraxin 3 (PTX3) expression and release by neutrophils in vitro and in ulcerative colitis
    Alexander S Savchenko
    Department of Cellular Function, Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences, Chuou ku, Niigata, Japan
    Pathol Int 61:290-7. 2011
    Pentraxin 3 (PTX3) is the first identified long pentraxin, and it is rapidly produced and released by several cell types in response to proinflammatory signals...
  71. pmc Pathogen recognition by the long pentraxin PTX3
    Federica Moalli
    Department of Immunology and Inflammation, Istituto Clinico Humanitas IRCCS, Via Manzoni 113, 20089 Rozzano, Italy
    J Biomed Biotechnol 2011:830421. 2011
    ..The long pentraxin PTX3 is a prototypic soluble PRM that is produced at sites of infection and inflammation by both somatic and immune ..
  72. pmc High pentraxin 3 level predicts septic shock and bacteremia at the onset of febrile neutropenia after intensive chemotherapy of hematologic patients
    Matti Vänskä
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Haematologica 96:1385-9. 2011
    ..High level of pentraxin 3 predicts septic shock and bacteremia already at the onset of febrile neutropenia. (ClinicalTrials.gov Identifier: NCT00781040.)...
  73. doi Plasma PTX3 protein levels inversely correlate with insulin secretion and obesity, whereas visceral adipose tissue PTX3 gene expression is increased in obesity
    O Osorio-Conles
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Diagonal, 645, E 08028 Barcelona, Spain
    Am J Physiol Endocrinol Metab 301:E1254-61. 2011
    Plasma acutephase protein pentraxin 3 (PTX3) concentration is dysregulated in human obesity and metabolic syndrome...
  74. doi Pentraxins in humoral innate immunity
    Antonio Inforzato
    Istituto Clinico Humanitas IRCCS, Via Manzoni 113, 20089 Rozzano, Italy
    Adv Exp Med Biol 946:1-20. 2012
    ..The long pentraxin PTX3 is a prototypic soluble PRM that is produced at sites of infection and inflammation by both somatic and immune ..
  75. ncbi Number of endothelial progenitor cells in peripheral artery disease as a marker of severity and association with pentraxin-3, malondialdehyde-modified low-density lipoprotein and membrane type-1 matrix metalloproteinase
    Tetsuji Morishita
    Department of Cardiovascular Medicine, University of Fukui Hospital, Matsuoka, Fukui, Japan
    J Atheroscler Thromb 19:149-58. 2012
    ..Despite the occurrence of endothelial dysfunction in peripheral artery disease (PAD), few data are available on EPC mobilization in this setting...
  76. doi Pentraxin 3: a novel and independent prognostic marker in ischemic stroke
    Wi Sun Ryu
    Department of Neurology, Seoul National University Hospital, Jongno gu, Seoul, Republic of Korea
    Atherosclerosis 220:581-6. 2012
    Pentraxin 3 (PTX3) is one of the pattern-recognition receptors related to the initial step of the immune response with C-reactive protein, but the physiologic and pathologic functions are not fully understood...
  77. doi Serum Fetuin-A and Pentraxin3 in hemodialysis and renal transplant patients
    Hassan Argani
    Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
    Clin Biochem 45:775-9. 2012
    The aim of the present study was to evaluate of Fetuin-A and Pentraxin3 (PTX3) as the main factors for vascular calcification and inflammation in hemodialysis (HD) and renal transplant (RT) patients.
  78. doi The association between pentraxin 3 and insulin resistance in obese children at baseline and after physical activity intervention
    Sang Hui Chu
    Department of Clinical Nursing Science, Yonsei University College of Nursing, Nursing Policy and Research Institute, Biobehavioral Research Center, Seoul, Korea
    Clin Chim Acta 413:1430-7. 2012
    The role of pentraxin-3 (PTX3) in the development of insulin resistance is still not clear...
  79. pmc Pentraxin 3 (PTX3) is associated with severe sepsis and fatal disease in emergency room patients with suspected infection: a prospective cohort study
    Raija Uusitalo-Seppälä
    Department of Infectious Diseases, Satakunta Central Hospital, Pori, Finland
    PLoS ONE 8:e53661. 2013
    Early diagnostic and prognostic stratification of patients with suspected infection is a difficult clinical challenge. We studied plasma pentraxin 3 (PTX3) upon admission to the emergency department in patients with suspected infection.
  80. pmc Serum amyloid P is a sialylated glycoprotein inhibitor of influenza A viruses
    Emma R Job
    Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia
    PLoS ONE 8:e59623. 2013
    Members of the pentraxin family, including PTX3 and serum amyloid P component (SAP), have been reported to play a role in innate host defence against a range of microbial pathogens, yet little is known regarding their antiviral activities...
  81. doi Pentraxin 3 is a marker of early joint inflammation in patients with juvenile idiopathic arthritis
    Shai Padeh
    Department of Pediatrics A, Edmond and Lily Safra Children s Hospital, Sheba Medical Center, Tel Hashomer, Israel
    Immunol Res 56:444-50. 2013
    Pentraxin 3 (PTX3) is an acute phase protein produced in different body tissues...
  82. doi The role of pentraxin 3 as diagnostic value in classification of patients with heart failure
    Sermin Duran
    Umraniye Education and Research Hospital, Medical Biochemistry Laboratory, Istanbul, Turkey
    Clin Biochem 46:983-7. 2013
    Pentraxin 3 (PTX3) is a new inflammatory marker that is the prototype of the long pentraxin group, while C-reactive protein (CRP) is the short pentraxin group...
  83. doi Association of plasma pentraxin 3 with arterial stiffness in overweight and obese individuals
    Asako Miyaki
    Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Am J Hypertens 26:1250-5. 2013
    ..The degree of arterial stiffness in obese individuals is greater than that in normal-weight subjects. Pentraxin 3 (PTX3) is mainly produced by vascular tissues and exerts a cardioprotective effect...
  84. doi Prototypic long pentraxin PTX3 is present in breast milk, spreads in tissues, and protects neonate mice from Pseudomonas aeruginosa lung infection
    Sebastien Jaillon
    L Université Nantes Angers Le Mans, Universite d Angers, 49000 Angers, France
    J Immunol 191:1873-82. 2013
    ..Pentraxin 3 (PTX3), the prototypic long pentraxin, is a soluble pattern recognition receptor involved in the initiation of protective ..
  85. doi The humoral pattern recognition molecule PTX3 is a key component of innate immunity against urinary tract infection
    Sebastien Jaillon
    Humanitas Clinical Research Center, Via Manzoni 56, 20089 Rozzano Milano, Italy Electronic address
    Immunity 40:621-32. 2014
    ..We investigated the role of the soluble pattern recognition molecule pentraxin 3 (PTX3), a key component of the humoral arm of innate immunity, in UTIs...
  86. ncbi Multimer formation and ligand recognition by the long pentraxin PTX3. Similarities and differences with the short pentraxins C-reactive protein and serum amyloid P component
    B Bottazzi
    From the Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milano, Italy
    J Biol Chem 272:32817-23. 1997
    b>PTX3 is a prototypic long pentraxin consisting of a C-terminal 203-amino acid pentraxin-like domain coupled with an N-terminal 178-amino acid unrelated portion...
  87. ncbi Interferon-gamma inhibits expression of the long pentraxin PTX3 in human monocytes
    N Polentarutti
    Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Eur J Immunol 28:496-501. 1998
    b>PTX3 is a prototypic long pentraxin expressed by various cell types, most prominently monocytes and endothelial cells, in response to interleukin-1 (IL-1), tumor necrosis factor (TNF) and bacterial products...
  88. ncbi Biochemical and functional characterization of the interaction between pentraxin 3 and C1q
    Alma J Nauta
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 33:465-73. 2003
    Pentraxin 3 (PTX3) is a recently characterized member of the pentraxin family of acute-phase proteins produced during inflammation...
  89. ncbi Identification of an antiangiogenic FGF2-binding site in the N terminus of the soluble pattern recognition receptor PTX3
    Maura Camozzi
    Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, 25123 Brescia, Italy
    J Biol Chem 281:22605-13. 2006
    Long-pentraxin 3 (PTX3) is a soluble pattern recognition receptor with non-redundant functions in inflammation and innate immunity...
  90. doi Pentraxin 3 in amniotic fluid as a marker of intra-amniotic inflammation in women with preterm premature rupture of membranes
    Marian Kacerovsky
    Department of Obstetrics and Gynecology, Charles University, Medical School and University, Hradec Kralove, Czech Republic
    Int J Gynaecol Obstet 108:203-6. 2010
    To determine whether amniotic fluid levels of pentraxin 3 (PTX3) are of value in the prenatal diagnosis of acute histological chorioamnionitis in preterm premature rupture of membranes (PPROM).
  91. pmc Uric acid and pentraxin-3 levels are independently associated with coronary artery disease risk in patients with stage 2 and 3 kidney disease
    Mehmet Kanbay
    Division of Nephrology, Department of Medicine, Fatih University School of Medicine, Ankara, Turkey
    Am J Nephrol 33:325-31. 2011
    ....
  92. pmc Pentraxin 3 (PTX3) is associated with cardiovascular risk factors: the Health 2000 Survey
    J Jylhävä
    Department of Microbiology and Immunology, Medical School, University of Tampere, Finland
    Clin Exp Immunol 164:211-7. 2011
    Pentraxin 3 (PTX3) is a novel candidate immunoinflammatory marker that has been reported to be associated with cardiometabolic risk factors and to predict adverse outcomes in individuals with cardiovascular disease (CVD)...
  93. pmc Long pentraxin 3/tumor necrosis factor-stimulated gene-6 interaction: a biological rheostat for fibroblast growth factor 2-mediated angiogenesis
    Daria Leali
    Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy
    Arterioscler Thromb Vasc Biol 32:696-703. 2012
    ..is a major proangiogenic inducer inhibited by the interaction with the soluble pattern recognition receptor long pentraxin 3 (PTX3)...
  94. ncbi Different distribution of pentraxin 3 and C-reactive protein in coronary atherosclerotic plaques
    Yunosuke Matsuura
    Department of Internal Medicine, University of Miyazaki, Miyazaki, Japan
    J Atheroscler Thromb 19:837-45. 2012
    To understand the differences between histopathological characteristics related to PTX3 (pentraxin 3) and CRP (C-reactive protein) in coronary atherosclerotic plaques.
  95. pmc Variation in PTX3 is associated with primary graft dysfunction after lung transplantation
    Joshua M Diamond
    Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania School of Medicine, 3400 Spruce St, 8 West Gates, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 186:546-52. 2012
    Elevated long pentraxin-3 (PTX3) levels are associated with the development of primary graft dysfunction (PGD) after lung transplantation. Abnormalities in innate immunity, mediated by PTX3 release, may play a role in PGD pathogenesis.
  96. pmc Long pentraxin 3: experimental and clinical relevance in cardiovascular diseases
    Fabrizia Bonacina
    Department of Pharmacological and Biomolecular Sciences, Universita degli Studi di Milano, 20133 Milan, Italy
    Mediators Inflamm 2013:725102. 2013
    Pentraxin 3 (PTX3) is an essential component of the humoral arm of innate immunity and belongs, together with the C-reactive protein (CRP) and other acute phase proteins, to the pentraxins' superfamily: soluble, multifunctional, pattern ..
  97. ncbi The long pentraxin 3 in cardiac surgery: distinct responses in "on-pump" and "off-pump" patients
    Pavel Kunes
    Department of Cardiac Surgery, Charles University in Prague, University Hospital and Faculty of Medicine in Hradec Králové, Czech Republic
    Scand Cardiovasc J 41:171-9. 2007
    Pentraxin 3 (PTX3) is a newly identified acute phase reactant with non-redundant functions in innate immunity...
  98. ncbi Human herpesvirus 8-derived viral IL-6 induces PTX3 expression in Kaposi's sarcoma cells
    Mariam Klouche
    Institute of Clinical Pathology, Department of Laboratory Medicine, Robert Bosch Hospital and Robert Bosch Society for Medical Research, Stuttgart, Germany
    AIDS 16:F9-18. 2002
    ..To analyse if human herpesvirus 8 (HHV8)-derived viral interleukin-6 (vIL-6) has the capacity to activate Kaposi's sarcoma (KS) cells to elicit a local acute-phase response...
  99. ncbi Promoter structure and transcriptional activation of the murine TSG-14 gene encoding a tumor necrosis factor/interleukin-1-inducible pentraxin protein
    A Altmeyer
    Department of Microbiology, New York University Medical Center, New York 10016, USA
    J Biol Chem 270:25584-90. 1995
    ....
  100. pmc Pattern recognition by pentraxins
    Alok Agrawal
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    Adv Exp Med Biol 653:98-116. 2009
    ..The prototype protein of the long pentraxin group is pentraxin 3 (PTX3)...
  101. ncbi High-level expression and efficient purification of recombinant human long pentraxin PTX3 in Chinese hamster ovary cells
    Vincenzo Rivieccio
    TECNOGEN SCpA, Località La Fagianeria I 81015 Piana di Monteverna CE, Italy
    Protein Expr Purif 51:49-58. 2007
    b>PTX3 is a secreted multimeric glycoprotein which plays a key role in innate immunity by activating the classical complement pathway through specific recognition of the C1q subunit...

Research Grants17

  1. Domains of Inflammation and Risk of Dementia
    Annette L Fitzpatrick; Fiscal Year: 2013
    ..Assessment of these biomarkers to predict risk of dementia prior to cognitive symptoms emerging will increase ability to develop strategies of prevention and early detection. ..
  2. James T Handa; Fiscal Year: 2015
    ..Define i) the origin of CFH that regulates complement activation in the RPE, and ii) the regulatory role of PTX3 on CFH within Bruch's membrane;3...
  3. Anti-angiogenesis of HC-HA Covalent Complex and PTX3 Purified from Fetal Membrane
    Scheffer C G Tseng; Fiscal Year: 2011
    ..evidence supporting that HC"HA purified from the CH is 25 fold more potent than that purified from the AM and that PTX3 from the CH may enhance the HC"HA's suppression of vascular endothelial proliferation...
  4. LH ACTION IN OVARIAN CELL DIFFERENTIATION
    JoAnne S Richards; Fiscal Year: 2013
    ..the expression of specific genes: the EGF-like factors (Areg, Ereg, Btc), matrix factors (Has2, Ptgs2, Tnfaip6, Ptx3) and cytokines (Il6)...
  5. Regulation of Key Processes in Oocyte Biology
    Martin Matzuk; Fiscal Year: 2007
    ..Compromised fertility in knockout models lacking these oocyte-specific genes would demonstrate that these proteins are potential contraceptive targets and possibly mutated in infertile women. ..
  6. EX VIVO EXPANSION OF RPE CELLS FOR TRANSPLANTATION
    Scheffer Tseng; Fiscal Year: 2005
    ..Success in accomplishing these goals will allow us to engineer this new tissue-based "Biologies" to restore sights in patients suffering ARMD or other retinal diseases in which RPE is dysfunctional. ..
  7. DEVELOPMENT OF SUTURELESS AMNIOTIC MEMBRANE GRAFT
    Scheffer Tseng; Fiscal Year: 2007
    ..Taken together, we may further promote our business development by expanding the market potential using Prokera(tm) for suture-less AMT. [unreadable] [unreadable]..
  8. ANTI-SCARRING AND ANTI-INFLAMMATORY EFFECTS OF AMNIOTIC MEMBRANE EXTRACTS
    Scheffer Tseng; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  9. TRANSPLANTATION OF EXPANDED LIMBAL EPITHELIAL STEM CELLS
    Scheffer Tseng; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  10. Post-transcriptional gene regulation in the ovary
    Lane Christenson; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  11. In Vivo Trapping of Genes Involved in Ovulation
    Lane Christenson; Fiscal Year: 2005
    ..These studies will for the first time determine the mechanism and cell signaling pathways by which the Cebpb transcription factor promotes ovulation. ..
  12. Signal Transduction in Depression
    Richard Shelton; Fiscal Year: 2008
    ..These studies may shed light on important cellular mediators of depression and provide new targets for amelioration. [unreadable] [unreadable]..
  13. KALLIKREINS AS DIAGNOSTIC MARKERS OF OVARIAN CARCINOMA
    Eleftherios Diamandis; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  14. A New Biomarker for Ovarian Cancer Detection
    Eleftherios Diamandis; Fiscal Year: 2003
    ..In this grant proposal, we describe further studies, which will examine in greater detail, the ability of a test for the amount of this protein in blood to correctly diagnose the presence of ovarian cancer. ..
  15. MOLECULAR NEUROBIOLOGY OF DEPRESSION
    Richard Shelton; Fiscal Year: 2003
    ..Develop further expertise in basic molecular biological methods; 2. Develop new projects oriented to future funding opportunities; and 3. Continue to mentor the next generation of investigators. ..
  16. Human Kallikrein 4 (hK4): A New Prostatic Biomarker?
    Eleftherios Diamandis; Fiscal Year: 2003
    ..If successful, our research will contribute to the development of new prostatic biomarkers and possibly, to better diagnosis which may lead to better clinical outcomes and reduced healthcare costs. ..