PTPMT1

Summary

Gene Symbol: PTPMT1
Description: protein tyrosine phosphatase, mitochondrial 1
Alias: DUSP23, MOSP, PLIP, PNAS-129, phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1, NB4 apoptosis/differentiation related protein, PTEN-like phosphatase, phosphoinositide lipid phosphatase
Species: human

Top Publications

  1. pmc Downregulation of the mitochondrial phosphatase PTPMT1 is sufficient to promote cancer cell death
    Natalie M Niemi
    Van Andel Research Institute, Department of Systems Biology, Grand Rapids, Michigan, United States of America
    PLoS ONE 8:e53803. 2013
  2. ncbi A PTEN-like phosphatase with a novel substrate specificity
    David J Pagliarini
    Department of Pharmacology, University of California, San Diego, La Jolla, California 92093 0721, USA
    J Biol Chem 279:38590-6. 2004
  3. doi Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators
    Nicole St-Denis
    Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada
    Cell Rep 17:2488-2501. 2016
  4. pmc The pseudophosphatase MK-STYX physically and genetically interacts with the mitochondrial phosphatase PTPMT1
    Natalie M Niemi
    Laboratory of Systems Biology, Van Andel Research Institute, Grand Rapids, Michigan, United States of America
    PLoS ONE 9:e93896. 2014
  5. doi Graft of the gelatin sponge scaffold containing genetically-modified neural stem cells promotes cell differentiation, axon regeneration, and functional recovery in rat with spinal cord transection
    Bao Ling Du
    Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, Guangdong, China
    J Biomed Mater Res A 103:1533-45. 2015
  6. pmc Recalibration of the SCORE risk chart for the Russian population
    Dmitri A Jdanov
    Max Planck Institute for Demographic Research, KonradZuse Str 1, 18057, Rostock, Germany
    Eur J Epidemiol 29:621-8. 2014
  7. pmc Maintenance of mouse hematopoietic stem cells ex vivo by reprogramming cellular metabolism
    Xia Liu
    Division of Hematology and Oncology, Department of Medicine, Center for Stem Cell and Regenerative Medicine, Case Western Reserve University, Cleveland, OH and
    Blood 125:1562-5. 2015
  8. pmc PTPMT1 Inhibition Lowers Glucose through Succinate Dehydrogenase Phosphorylation
    Anjali K Nath
    Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA Broad Institute, Cambridge, MA 02142, USA Electronic address
    Cell Rep . 2015
  9. doi The degree of astrocyte activation in multiple system atrophy is inversely proportional to the distance to α-synuclein inclusions
    Rowan Radford
    Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia
    Mol Cell Neurosci 65:68-81. 2015
  10. pmc Bipartite Topology of Treponema pallidum Repeat Proteins C/D and I: OUTER MEMBRANE INSERTION, TRIMERIZATION, AND PORIN FUNCTION REQUIRE A C-TERMINAL β-BARREL DOMAIN
    Arvind Anand
    From the Departments of Medicine
    J Biol Chem 290:12313-31. 2015

Research Grants

  1. PTPMT1 Phosphatase and Hematopoietic Stem Cell Function
    Cheng Kui Qu; Fiscal Year: 2010
  2. Cheng Kui Qu; Fiscal Year: 2016
  3. TWO NOVEL CPLA2 BINDING PROTEINS AND CELL DEATH
    JOSEPH VINCENT BONVENTRE; Fiscal Year: 2010
  4. Phosphoinositide Phosphatases
    Jack E Dixon; Fiscal Year: 2013
  5. NATHAN JAMES LANNING; Fiscal Year: 2014
  6. CAROLYN ANN WORBY; Fiscal Year: 2014
  7. TWO NOVEL CPLA2 BINDING PROTEINS AND CELL DEATH
    Alice Sheridan; Fiscal Year: 2005
  8. MOLECULAR CHARACTERIZATION OF THE JCPK/BPK LOCUS
    ELIZABETH BRYDA; Fiscal Year: 2003
  9. SHP-2 Inhibitors as Potential Therapeutic Agents for JMML and Noonan Syndrome
    Cheng Kui Qu; Fiscal Year: 2008

Scientific Experts

  • Fred L Cohen
  • Dmitri Jdanov
  • Sachiko Kinoshita
  • Zhengjin Jiang
  • ALICE MARIE SHERIDAN
  • Adela Quesada
  • C A Dyer
  • Kaori Tomizawa
  • Cheng Kui Qu
  • Karen Panetta
  • Jared T Wilcox
  • Yolanda Aguilera
  • Jack E Dixon
  • Ji Zhang
  • CAROLYN ANN WORBY
  • NATHAN JAMES LANNING
  • ELIZABETH BRYDA
  • JOSEPH VINCENT BONVENTRE
  • Arvind Anand
  • Natalie M Niemi
  • Xia Liu
  • Wen Mei Yu
  • David J Pagliarini
  • Carolyn A Worby
  • Jinhua Shen
  • James L Engel
  • E Balada
  • LISA LEON GALLEGOS
  • Nicole St-Denis
  • Sheng Chen
  • Chunyu Liu
  • Aiping Wu
  • Amena W Smith
  • Sun Young Kim
  • Qin Qin Xu
  • Navaneethan Palanisamy
  • Sebastian Salentin
  • Bao Ling Du
  • Anjali K Nath
  • Rowan Radford
  • Amit Luthra
  • Justin D Radolf
  • Stuart P Weisberg
  • Morgan Ledoyt
  • Jeffrey P Mackeigan
  • Nathan J Lanning
  • Laura M Westrate
  • Sarah E Herlihy
  • Phildrich G Teh
  • Hwangseo Park
  • Toren Finkel
  • Mark J Chen
  • Gerard Manning
  • Junyu Xiao
  • Sina Ghaemmaghami
  • Fang Yu Lin
  • Karim El-Kouhen
  • Hongli Yang
  • Jing Ping Tang
  • Fang Chueh Liu
  • Dahlia Doughty-Shenton
  • Shawn J Chua
  • Sun Hee Kim
  • Rakhi Agarwal
  • Michel L Tremblay
  • Sandra E Wiley
  • Patrick J Casey
  • Katarina Muckova
  • Ki Bum Park
  • Yves Boisclair
  • Yannick Doyon
  • Qihan Wu
  • J Ordi-Ros
  • L Felip
  • M Vilardell-Tarres
  • Jeanette M Stafford
  • Baerbel Rohrer
  • Jennifer A Brody
  • Omri Gottesman
  • George J Papanicolaou
  • Martin G Larson
  • David R Weir
  • J A Sloane
  • Baek Soo Han
  • Aravinda Chakravarti
  • Honggang Fu
  • Supriti Samantaray
  • Mathew E Sowa
  • Eric Boerwinkle
  • Ramachandran S Vasan

Detail Information

Publications60

  1. pmc Downregulation of the mitochondrial phosphatase PTPMT1 is sufficient to promote cancer cell death
    Natalie M Niemi
    Van Andel Research Institute, Department of Systems Biology, Grand Rapids, Michigan, United States of America
    PLoS ONE 8:e53803. 2013
    Protein Tyrosine Phosphatase localized to the Mitochondrion 1 (PTPMT1) is a dual specificity phosphatase exclusively localized to the mitochondria, and has recently been shown to be a critical component in the cardiolipin biosynthetic ..
  2. ncbi A PTEN-like phosphatase with a novel substrate specificity
    David J Pagliarini
    Department of Pharmacology, University of California, San Diego, La Jolla, California 92093 0721, USA
    J Biol Chem 279:38590-6. 2004
    We show that a novel PTEN-like phosphatase (PLIP) exhibits a unique preference for phosphatidylinositol 5-phosphate (PI(5)P) as a substrate in vitro...
  3. doi Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators
    Nicole St-Denis
    Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada
    Cell Rep 17:2488-2501. 2016
    ..in mitotic exit, CDC14A in regulating microtubule integrity, PTPRF in mitotic retraction fiber integrity, and DUSP23 in centriole duplication...
  4. pmc The pseudophosphatase MK-STYX physically and genetically interacts with the mitochondrial phosphatase PTPMT1
    Natalie M Niemi
    Laboratory of Systems Biology, Van Andel Research Institute, Grand Rapids, Michigan, United States of America
    PLoS ONE 9:e93896. 2014
    ..We identified the mitochondrial phosphatase, PTPMT1 (PTP localized to mitochondrion 1), as the most significant and unique interaction partner of MK-STYX...
  5. doi Graft of the gelatin sponge scaffold containing genetically-modified neural stem cells promotes cell differentiation, axon regeneration, and functional recovery in rat with spinal cord transection
    Bao Ling Du
    Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, Guangdong, China
    J Biomed Mater Res A 103:1533-45. 2015
    ..microtubule associated protein (Map2), postsynaptic density (PSD95), and mouse oligodendrocyte special protein (MOSP) positive cells...
  6. pmc Recalibration of the SCORE risk chart for the Russian population
    Dmitri A Jdanov
    Max Planck Institute for Demographic Research, KonradZuse Str 1, 18057, Rostock, Germany
    Eur J Epidemiol 29:621-8. 2014
    ..Petersburg populations (SCORE-MoSP)...
  7. pmc Maintenance of mouse hematopoietic stem cells ex vivo by reprogramming cellular metabolism
    Xia Liu
    Division of Hematology and Oncology, Department of Medicine, Center for Stem Cell and Regenerative Medicine, Case Western Reserve University, Cleveland, OH and
    Blood 125:1562-5. 2015
    ..treatment with alexidine dihydrochloride, an antibiotic and a selective inhibitor of the mitochondrial phosphatase Ptpmt1, which is crucial for the differentiation of HSCs, reprogrammed cellular metabolism from mitochondrial aerobic ..
  8. pmc PTPMT1 Inhibition Lowers Glucose through Succinate Dehydrogenase Phosphorylation
    Anjali K Nath
    Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA Broad Institute, Cambridge, MA 02142, USA Electronic address
    Cell Rep . 2015
    ..We found that alexidine inhibits the PTEN-like mitochondrial phosphatase PTPMT1 and that other pharmacological and genetic means of inactivating PTPMT1 also decrease glucose levels in zebrafish...
  9. doi The degree of astrocyte activation in multiple system atrophy is inversely proportional to the distance to α-synuclein inclusions
    Rowan Radford
    Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia
    Mol Cell Neurosci 65:68-81. 2015
    ..syn addition caused ERK-dependent activation of rat astrocytes and perinuclear α-syn inclusions in mature (MOSP-positive) rat oligodendrocytes...
  10. pmc Bipartite Topology of Treponema pallidum Repeat Proteins C/D and I: OUTER MEMBRANE INSERTION, TRIMERIZATION, AND PORIN FUNCTION REQUIRE A C-TERMINAL β-BARREL DOMAIN
    Arvind Anand
    From the Departments of Medicine
    J Biol Chem 290:12313-31. 2015
    ..contains N- and C-terminal domains (TprC(N) and TprC(C)) orthologous to regions in the major outer sheath protein (MOSP(N) and MOSP(C)) of Treponema denticola and that TprC(C) is solely responsible for β-barrel formation, ..
  11. pmc PLIP: fully automated protein-ligand interaction profiler
    Sebastian Salentin
    Biotechnology Center BIOTEC, TU Dresden, Tatzberg 47 49, 01307 Dresden, Germany
    Nucleic Acids Res 43:W443-7. 2015
    ..Here, we present the protein-ligand interaction profiler (PLIP), a novel web service for fully automated detection and visualization of relevant non-covalent protein-ligand ..
  12. doi Profiling analysis of protein tyrosine phosphatases during neuronal differentiation
    Sun Young Kim
    Functional Genomics Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305 806, Republic of Korea
    Neurosci Lett 612:219-24. 2016
    ..In particular, it was found that dual-specific phosphatase23 (DUSP23) affected neuronal differentiation...
  13. ncbi Biophysical Studies on HCV 1a NS3/4A Protease and Its Catalytic Triad in Wild Type and Mutants by the In Silico Approach
    Navaneethan Palanisamy
    Synthetic Biology Group, Institute of Pharmacy and Molecular Biotechnology IPMB, University of Heidelberg, Im Neuenheimer Feld 267 BioQuant, 69120, Heidelberg, Germany
    Interdiscip Sci . 2016
    ..g. DoGSiteScorer, SRide, ASA-View, WHAT IF, elNémo, CABS-flex, PatchDock and PLIP)...
  14. pmc Calpain inhibition reduces structural and functional impairment of retinal ganglion cells in experimental optic neuritis
    Amena W Smith
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina, USA
    J Neurochem 139:270-284. 2016
    ..acuity and preserves retinal ganglion cells (Brn3a, brain-specific homeobox/POU domain protein 3A) and their axons (MOSP, myelin oligodendrocyte-specific protein)...
  15. pmc Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci
    Chunyu Liu
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, Massachusetts, USA
    Nat Genet 48:1162-70. 2016
    ..were also observed for the aggregation of rare and low-frequency missense variants in three genes, NPR1, DBH, and PTPMT1. In addition, blood pressure associations at 39 previously reported loci were confirmed...
  16. doi Ptpmt1 induced by HIF-2α regulates the proliferation and glucose metabolism in erythroleukemia cells
    Qin Qin Xu
    High Altitude Medicine of Ministry of Chinese Education and Research Center for High Altitude Medicine, Qinghai University, Xining, 810001, PR China Qinghai Provincial People s Hospital, Xining, PR China
    Biochem Biophys Res Commun 471:459-65. 2016
    ..In this study, we presented evidence that mitochondrial phosphatase Ptpmt1 is a hypoxia response molecule that regulates cell proliferation, survival and glucose metabolism in human ..
  17. pmc DUSP23 is over-expressed and linked to the expression of DNMTs in CD4+ T cells from systemic lupus erythematosus patients
    E Balada
    Research Unit in Systemic Autoimmune Diseases, Vall d Hebron Research Institute, Universitat Autonoma de Barcelona, Barcelona, Spain
    Clin Exp Immunol 187:242-250. 2017
    We evaluated the transcriptional expression of dual-specificity protein phosphatase 23 (DUSP23) in CD4+ T cells from 30 systemic lupus erythematosus (SLE) patients and 30 healthy controls...
  18. ncbi A parameterized logarithmic image processing method with Laplacian of Gaussian filtering for lung nodule enhancement in chest radiographs
    Sheng Chen
    School of Optical Electrical and Computer Engineering, University of Shanghai for Science and Technology, Shanghai, China
    Med Biol Eng Comput 54:1793-1806. 2016
    ..In this paper, we proposed a parameterized logarithmic image processing (PLIP) method combined with the Laplacian of a Gaussian (LoG) filter to enhance lung nodules in CXRs...
  19. doi Hierarchical MoS2@MoP core-shell heterojunction electrocatalysts for efficient hydrogen evolution reaction over a broad pH range
    Aiping Wu
    Key Laboratory of Cluster Science, Ministry of Education of China, Beijing Institute of Technology, Beijing 100081, China
    Nanoscale 8:11052-9. 2016
    ..In this study, hierarchical flower-like MoS2@MoP core-shell heterojunctions (HF-MoSP) are designed as a promising catalyst for HER over a broad pH range...
  20. pmc A protein interaction map for cell-cell adhesion regulators identifies DUSP23 as a novel phosphatase for β-catenin
    LISA LEON GALLEGOS
    Cell Biology, Harvard Med School, Boston, MA, USA
    Sci Rep 6:27114. 2016
    ..Mechanistic studies of one novel CCARP which links to multiple cell-cell adhesion proteins, the phosphatase DUSP23, revealed that it promotes dephosphorylation of β-catenin at Tyr 142 and enhances the interaction between α- and ..
  21. pmc ZFX controls propagation and prevents differentiation of acute T-lymphoblastic and myeloid leukemia
    Stuart P Weisberg
    Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA
    Cell Rep 6:528-40. 2014
    ..Key Zfx target genes include the mitochondrial enzymes Ptpmt1 and Idh2, whose overexpression partially rescues the propagation of Zfx-deficient AML...
  22. ncbi Neuronal differentiation of stem cells isolated from adult muscle
    Marina Romero-Ramos
    Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095, USA
    J Neurosci Res 69:894-907. 2002
    ..After 4-6 days the cells expressed neuronal (Tuj1+, NF68), astrocytic (GFAP) and oligodendrocytic (MOSP+, MBP+) markers, both by immunocytochemistry and RT-PCR...
  23. doi Chromatography approaches for early screening of the phospholipidosis-inducing potential of pharmaceuticals
    Zhengjin Jiang
    Department of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drug Research, Jinan University, Guangzhou 510632, China
    J Pharm Biomed Anal 61:184-90. 2012
    ..within several different separation systems, was developed for screening phospholipidosis-inducing potential (PLIP) of pharmaceuticals...
  24. doi Pseudohomophone priming in lexical decision is not fragile in a sparse lexical neighborhood
    Sachiko Kinoshita
    ARC Centre of Excellence in Cognition and Its Disorders and Department of Psychology, Macquarie University, Sydney, Australia
    J Exp Psychol Learn Mem Cogn 38:764-75. 2012
    ..in English have found a reliable pseudohomophone priming advantage with orthographically similar primes (the klip-plip effect; Frost, Ahissar, Gotesman, & Tayeb, 2003; see Rastle & Brysbaert, 2006, for a review)...
  25. pmc Multiple operations on the same patient
    Fred L Cohen
    Private Practice of Neurological Surgery, Gary Roberts and Associates, West Palm Beach, Florida, USA
    Surg Neurol Int 3:S238-43. 2012
    ..surgery facility, performed a staggering number of procedures or "multiple operations on the same patient" (MOSP)...
  26. pmc Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation
    Wen Mei Yu
    Department of Medicine, Division of Hematology and Oncology, Center for Stem Cell and Regenerative Medicine, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA
    Cell Stem Cell 12:62-74. 2013
    ..Here we report that depletion of PTPMT1, a PTEN-like mitochondrial phosphatase, in inducible or hematopoietic-cell-specific knockout mice resulted in ..
  27. pmc Identification of a mammalian-type phosphatidylglycerophosphate phosphatase in the Eubacterium Rhodopirellula baltica
    Phildrich G Teh
    Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California 92093, USA
    J Biol Chem 288:5176-85. 2013
    ..We recently identified the mitochondrial phosphatase, PTPMT1, as the enzyme that converts phosphatidylglycerolphosphate (PGP) to phosphatidylglycerol, a critical step in the ..
  28. pmc The major outer sheath protein (Msp) of Treponema denticola has a bipartite domain architecture and exists as periplasmic and outer membrane-spanning conformers
    Arvind Anand
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA
    J Bacteriol 195:2060-71. 2013
    ..Domain Database (CDD) server revealed that Msp contains two conserved domains, major outer sheath protein(N) (MOSP(N)) and MOSP(C), spanning residues 77 to 286 and 332 to 543, respectively, within the N- and C-terminal regions of ..
  29. pmc A Dictyostelium secreted factor requires a PTEN-like phosphatase to slow proliferation and induce chemorepulsion
    Sarah E Herlihy
    Department of Biology, Texas A and M University, College Station, TX, USA
    PLoS ONE 8:e59365. 2013
    ..Combined, these results suggest that CnrN functions in a signal transduction pathway downstream of AprA and CfaD mediating some, but not all, of the effects of AprA and CfaD...
  30. ncbi Age-dependent myelin degeneration and proteolysis of oligodendrocyte proteins is associated with the activation of calpain-1 in the rhesus monkey
    J A Sloane
    Department of Pathology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Neurochem 84:157-68. 2003
    ..proteins 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) and myelin/oligodendrocyte-specific protein (MOSP) increased dramatically in white matter homogenates and myelin with age...
  31. ncbi Enhancement of gamma-aminobutyric acid production in Chungkukjang by applying a Bacillus subtilis strain expressing glutamate decarboxylase from Lactobacillus brevis
    Ki Bum Park
    Department of Life Science and Technology, Graduate School, Woosuk University, Jeonju 565 701, Korea
    Biotechnol Lett 28:1459-63. 2006
    For a foreign glutamate decarboxylase (GAD) to be expressed in Bacillus host system, a recombinant DNA (pLip/LbGAD) was constructed by ligating an LbGAD gene from Lactobacillus brevis OPK-3 into Escherichia coli-Bacillus shuttle vector, ..
  32. ncbi Firing up mitochondrial activities with PTPMT1
    Yves Boisclair
    Department of Animal Science, Cornell University, 259 Morrison Hall, Ithaca, New York 14853, USA
    Mol Cell 19:291-2. 2005
    Pagliarini et al (2005) recently identified a new mitochondrial specific protein tyrosine phosphatase, PTPMT1. This report comments on its consequences for mitochondrial function and on its potential to act as a therapeutic target in ..
  33. pmc Conformational transformation and selection of synthetic prion strains
    Sina Ghaemmaghami
    Institute for Neurodegenerative Diseases, University of California San Francisco, San Francisco, CA 94143, USA
    J Mol Biol 413:527-42. 2011
    ..the mechanism of prion strain transformation, we studied the physicochemical evolution of a mouse synthetic prion (MoSP) strain, MoSP1, after repeated passage in mice and cultured cells...
  34. doi Application of porcine lipase secreted by pichia pastoris to improve fat digestion and growth performance of postweaning piglets
    Fang Chueh Liu
    Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan
    J Agric Food Chem 58:3322-9. 2010
    The aim of the study was to use Pichia pastoris to express a recombinant porcine lipase gene (pLip). The expression-secretion cassette was constructed using the P...
  35. ncbi GFAP-positive and myelin marker-positive glia in normal and pathologic environments
    C A Dyer
    Department of Pediatrics and Neurology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Neurosci Res 60:412-26. 2000
    ..protein (MBP) gene promoter, GFAP-positive/beta-galactosidase-positive and myelin/oligodendrocyte-specific protein (MOSP)-positive/beta-galactosidase-positive cells were detected in subcortical white matter and in perivascular locations ..
  36. pmc PLIP, a novel splice variant of Tip60, interacts with group IV cytosolic phospholipase A(2), induces apoptosis, and potentiates prostaglandin production
    A M Sheridan
    Medical Services, Massachusetts General Hospital, and Department of Medicine, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Mol Cell Biol 21:4470-81. 2001
    ..We have identified a nuclear protein, cPLA(2)-interacting protein (PLIP), a splice variant of human Tip60, which interacts with the amino terminal region of cPLA(2)...
  37. ncbi A PTEN-related 5-phosphatidylinositol phosphatase localized in the Golgi
    Sylvain Merlot
    Section of Cell and Developmental Biology, Division of Biological Sciences, Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093 0634, USA
    J Biol Chem 278:39866-73. 2003
    ..core motif, we have identified a new protein in the Dictyostelium genome called phospholipid-inositol phosphatase (PLIP), which defines a new subfamily of phosphoinositide phosphatases clearly distinct from PTEN or other closely ..
  38. pmc Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans
    Yannick Doyon
    Laval University Cancer Research Center, Hotel Dieu de Quebec, Quebec City, Quebec G1R 2J6, Canada
    Mol Cell Biol 24:1884-96. 2004
    ..We demonstrate here that NuA4 complexes are indeed present in human cells. Tip60 and its splice variant Tip60b/PLIP were purified as stable HAT complexes associated with identical polypeptides, with 11 of the 12 proteins being ..
  39. ncbi Peripapillary glial cells in the chick retina: A special glial cell type expressing astrocyte, radial glia, neuron, and oligodendrocyte markers throughout development
    Adela Quesada
    Departamento de Ciencias Morfológicas e Instituto de Biología del Desarrollo, Facultad de Medicina, Universidad de Sevilla, Sevilla, Spain
    Glia 46:346-55. 2004
    ..They also express an antigen specific to myelin and oligodendrocytes, MOSP, and a glial antigen, 3CB2, expressed by radial glia and astrocytes throughout the CNS...
  40. ncbi Molecular cloning and characterization of a novel dual-specificity phosphatase 23 gene from human fetal brain
    Qihan Wu
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, PR China
    Int J Biochem Cell Biol 36:1542-53. 2004
    ..In this study, a novel human dual-specificity protein phosphatases gene named dual-specificity phosphatase 23 (DUSP23) was isolated by large-scale sequencing analysis of a human fetal brain cDNA library...
  41. ncbi The protective role of squalene in alcohol damage in the chick embryo retina
    Yolanda Aguilera
    Instituto de Biologia del Desarrollo, Facultad de Medicina, Universidad de Sevilla, Avda Sanchez Pizjuan s n, 41009 Seville, Spain
    Exp Eye Res 80:535-43. 2005
    ..At E19 the recuperation of the expression of myelin oligodendrocyte specific protein (MOSP) in alcohol+squalene-treated embryos was recorded...
  42. ncbi cPLA2-interacting protein, PLIP, causes apoptosis and decreases G1 phase in mesangial cells
    Katarina Muckova
    Renal Div, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Physiol Renal Physiol 290:F70-9. 2006
    ..Kidney Int 52: 294-308, 199). cPLA2-interacting protein (PLIP), the Tip60 splice variant, interacts with cPLA2 and enhances the susceptibility of renal mesangial cells to serum ..
  43. ncbi Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells
    David J Pagliarini
    Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA
    Mol Cell 19:197-207. 2005
    ..We have discovered that a member of the dual-specific protein tyrosine phosphatase (DS-PTP) family, PTPMT1 (PTP localized to the Mitochondrion 1) resides nearly exclusively in mitochondria...
  44. ncbi Physicochemical and cell-based approach for early screening of phospholipidosis-inducing potential
    Kaori Tomizawa
    Worldwide Safety Sciences, Pfizer Global Research and Development, Nagoya Laboratories Pfizer Inc, Japan
    J Toxicol Sci 31:315-24. 2006
    ..We employed a test set of 33 compounds including 11 in-house compounds. The phospholipidosis-inducing potential (PLIP) of the test set compounds was determined by the fluorescence-labeled lipid accumulation assay using isolated rat ..
  45. ncbi Discovery of three novel lipase ( lipA1 , lipA2 , and lipA3) and lipase-specific chaperone ( lipB) genes present in Acinetobacter sp. DYL129
    Sun Hee Kim
    Department of Biotechnology, Faculty of Natural Resources and Life Science, Dong A University, Busan, 604 714, South Korea
    Appl Microbiol Biotechnol 77:1041-51. 2008
    ..A genomic library was constructed by using DYL129 fragment digested with HindIII and a recombinant plasmid, pLip-1, was selected for further analysis by colony polymerase chain reaction (PCR). Sequencing of a 3...
  46. doi Structure of human dual specificity protein phosphatase 23, VHZ, enzyme-substrate/product complex
    Rakhi Agarwal
    Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    J Biol Chem 283:8946-53. 2008
    ..Dual specificity protein phosphatase 23 (DUSP23) or VHZ mediates dephosphorylation of phospho-tyrosyl (pTyr) and phospho-seryl/threonyl (pSer/pThr) residues in ..
  47. doi Neural progenitors, neurons and oligodendrocytes from human umbilical cord blood cells in a serum-free, feeder-free cell culture
    Shawn J Chua
    Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, Ont, Canada M5T 3H7
    Biochem Biophys Res Commun 379:217-21. 2009
    ..Early stage oligodendrocyte markers CNPase, GalC, Olig2 and the late-stage marker MOSP are observed, as is the Schwann cell marker PMP22...
  48. doi Structure-based virtual screening approach to the discovery of novel PTPMT1 phosphatase inhibitors
    Hwangseo Park
    Department of Bioscience and Biotechnology, Sejong University, 98 Kunja dong, Kwangjin ku, Seoul 143 747, Republic of Korea
    Bioorg Med Chem Lett 22:1271-5. 2012
    Dual-specificity protein tyrosine phosphatase localized to mitochondrion 1 (PTPMT1) has recently proved to be a promising therapeutic target for the treatment of type II diabetes...
  49. pmc Pharmacological targeting of the mitochondrial phosphatase PTPMT1
    Dahlia Doughty-Shenton
    Department of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina 27710 3813, USA
    J Pharmacol Exp Ther 333:584-92. 2010
    ..PTP localized to mitochondrion 1 (PTPMT1) is a recently discovered dual-specificity phosphatase that has been implicated in the regulation of insulin ..
  50. pmc VHZ is a novel centrosomal phosphatase associated with cell growth and human primary cancers
    Jing Ping Tang
    Institute of Molecular and Cell Biology, A STAR Agency for Science, Technology and Research, Proteos, Singapore
    Mol Cancer 9:128. 2010
    VHZ is a VH1-like (member Z) dual specific protein phosphatase encoded by DUSP23 gene. Some of the dual specific protein phosphatases (DSPs) play an important role in cell cycle control and have shown to be associated with carcinogenesis...
  51. pmc Dual-specificity phosphatase 23 mediates GCM1 dephosphorylation and activation
    Fang Yu Lin
    Graduate Institute of Biochemical Sciences, National Taiwan University, Nankang, Taipei 115, Taiwan
    Nucleic Acids Res 39:848-61. 2011
    ..Here we show that the interaction of GCM1 and dual-specificity phosphatase 23 (DUSP23) is enhanced by PKA-dependent phosphorylation of GCM1 on Ser269 and Ser275...
  52. doi Parameterized logarithmic framework for image enhancement
    Karen Panetta
    Department of Electrical and Computer Engineering, Tufts University, Medford, MA 02155, USA
    IEEE Trans Syst Man Cybern B Cybern 41:460-73. 2011
    ..In this paper, we introduce a parameterized LIP (PLIP) model that spans both the linear arithmetic and LIP operations and all scenarios in between within a single ..
  53. doi Myelin oligodendrocyte-specific protein is expressed in Müller cells of myelinated vertebrate retinas
    Adela Quesada
    Departamento de Anatomía e Instituto de Biología del Desarrollo, Facultad de Medicina, Universidad de Sevilla, Sevilla, Spain
    J Neurosci Res 89:674-88. 2011
    ..By immunohistochemistry, with a monoclonal antibody against myelin oligodendrocyte-specific protein (MOSP), we show that MOSP is intensely expressed in the MC and the optic-fiber layer (OFL) in myelinated but not in ..
  54. pmc Synaptically-competent neurons derived from canine embryonic stem cells by lineage selection with EGF and Noggin
    Jared T Wilcox
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada
    PLoS ONE 6:e19768. 2011
    ..or PDGFαα) produced phenotypes equivalent to primary canine neural cells including 3CB2+ radial progenitors, MOSP+ glia restricted precursors, VIM+/GFAP+ astrocytes, and TUBB3+/MAP2+/NFH+/SYN+ neurons...
  55. ncbi PTPMT1: connecting cardiolipin biosynthesis to mitochondrial function
    Karim El-Kouhen
    Goodman Cancer Research Centre, Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    Cell Metab 13:615-7. 2011
    ..In this issue, Zhang et al. (2011) highlight a critical role for PTPMT1, a mitochondrial phosphatase, in cardiolipin biogenesis and possibly in cardiolipin deficiency diseases...
  56. pmc Mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis
    Ji Zhang
    Department of Pharmacology, University of California San Diego, La Jolla, CA 92093, USA
    Cell Metab 13:690-700. 2011
    b>PTPMT1 was the first protein tyrosine phosphatase found localized to the mitochondria, but its biological function was unknown...
  57. pmc Posterior (outward) migration of the lamina cribrosa and early cupping in monkey experimental glaucoma
    Hongli Yang
    Optic Nerve Head Research Laboratory, Devers Eye Institute, Legacy Health System, Portland, Oregon 97232, USA
    Invest Ophthalmol Vis Sci 52:7109-21. 2011
    ..To quantify the lamina cribrosa insertion into the peripapillary sclera and optic nerve pia in normal (N) and early experimental glaucoma (EEG) monkey eyes...
  58. pmc Structural and functional analysis of PTPMT1, a phosphatase required for cardiolipin synthesis
    Junyu Xiao
    Department of Pharmacology, University of California, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 108:11860-5. 2011
    b>PTPMT1 (PTP localized to the Mitochondrion 1) is a member of the protein tyrosine phosphatase superfamily that is localized exclusively to the mitochondrion...
  59. ncbi Evidence for central nervous system glial cell plasticity in phenylketonuria
    C A Dyer
    E K Shriver Center, Waltham, MA 02254, USA
    J Neuropathol Exp Neurol 55:795-814. 1996
    ..basic protein (MBP), 2',3'-cyclic nucleotide 3'phosphohydrolase, and myelin/oligodendrocyte-specific protein (MOSP). However, Western blot analyses also showed that MBP isoform expression was aberrant...
  60. pmc A critical role of mitochondrial phosphatase Ptpmt1 in embryogenesis reveals a mitochondrial metabolic stress-induced differentiation checkpoint in embryonic stem cells
    Jinhua Shen
    Department of Medicine, Division of Hematology and Oncology, Case Comprehensive Cancer Center, Center for Stem Cell and Regenerative Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Mol Cell Biol 31:4902-16. 2011
    ..Global disruption of Ptpmt1, a mitochondrial Pten-like phosphatidylinositol phosphate (PIP) phosphatase, resulted in developmental arrest and ..

Research Grants9

  1. PTPMT1 Phosphatase and Hematopoietic Stem Cell Function
    Cheng Kui Qu; Fiscal Year: 2010
    ..b>PTPMT1, an evolutionarily conserved PTEN-like phosphatase, is localized to the mitochondrial inner membrane where ..
  2. Cheng Kui Qu; Fiscal Year: 2016
    ..b>PTPMT1, an evolutionarily conserved PTEN-like phosphatidylinositol phosphate (PIP) phosphatase, is localized to the ..
  3. TWO NOVEL CPLA2 BINDING PROTEINS AND CELL DEATH
    JOSEPH VINCENT BONVENTRE; Fiscal Year: 2010
    ..Cytosolic phospholipase A2 interacts with 3 proteins, including Tip60, a Tip60 splice variant which we have called PLIP, and SIRT2...
  4. Phosphoinositide Phosphatases
    Jack E Dixon; Fiscal Year: 2013
    ..will continue to study the regulation of the MTM family of PTPs as well as another novel phosphatase known as PTPMT1. In the next five years, we plan to develop a better understanding of how levels of PI(3)P transmit signals in the ..
  5. NATHAN JAMES LANNING; Fiscal Year: 2014
    ..screen to identify genes that regulate metabolism in cancer cells, protein tyrosine phosphatase, mitochondrial 1 (PTPMT1) was found to push cells towards a cancer metabolic program by inhibiting OXPHOS...
  6. CAROLYN ANN WORBY; Fiscal Year: 2014
    ..This proposal focuses on the mitochondrial phosphatase, PTPMT1 (formerly PLIP), the first resident mitochondrial phosphatase to be identified and functionally linked to energy ..
  7. TWO NOVEL CPLA2 BINDING PROTEINS AND CELL DEATH
    Alice Sheridan; Fiscal Year: 2005
    cPLA2 interacts with three proteins, including TipGO, a TipGO splice variant which we have called PLIP, and SIRT2...
  8. MOLECULAR CHARACTERIZATION OF THE JCPK/BPK LOCUS
    ELIZABETH BRYDA; Fiscal Year: 2003
    ..One of these interacting proteins, PLIP, (for Phospholipase A2-interacting protein), has an amino acid sequence containing a recently described MYST domain...
  9. SHP-2 Inhibitors as Potential Therapeutic Agents for JMML and Noonan Syndrome
    Cheng Kui Qu; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..