PTN

Summary

Gene Symbol: PTN
Description: pleiotrophin
Alias: HARP, HB-GAM, HBBM, HBGF-8, HBGF8, HBNF, HBNF-1, NEGF1, OSF-1, pleiotrophin, heparin affin regulatory protein, heparin-binding brain mitogen, heparin-binding growth factor 8, heparin-binding growth-associated molecule, heparin-binding neurite outgrowth promoting factor, heparin-binding neurite outgrowth-promoting factor 1, osteoblast-specific factor 1, pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)
Species: human

Top Publications

  1. pmc The survival-promoting peptide Y-P30 enhances binding of pleiotrophin to syndecan-2 and -3 and supports its neuritogenic activity
    Peter Landgraf
    Project Group Neuroplasticity, Leibniz Institute for Neurobiology, Brenneckestrasse 6, Magdeburg 39118, Germany
    J Biol Chem 283:25036-45. 2008
  2. ncbi Self-association of N-syndecan (syndecan-3) core protein is mediated by a novel structural motif in the transmembrane domain and ectodomain flanking region
    V K Asundi
    Sigfried and Janet Weis Center for Research, Geisinger Clinic, Danville, Pennsylvania 17822 2613, USA
    J Biol Chem 270:26404-10. 1995
  3. ncbi Bone mass loss due to estrogen deficiency is compensated in transgenic mice overexpressing human osteoblast stimulating factor-1
    H Masuda
    Research Institute for Neurological Diseases and Geriatrics, Second Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, 602, Japan
    Biochem Biophys Res Commun 238:528-33. 1997
  4. ncbi Increased keratinocyte proliferation by JUN-dependent expression of PTN and SDF-1 in fibroblasts
    Lore Florin
    Division of Signal Transduction and Growth Control, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Cell Sci 118:1981-9. 2005
  5. ncbi Serum stimulates Pleiotrophin gene expression in an AP-1-dependent manner in human endothelial and glioblastoma cells
    Evangelia Poimenidi
    Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, GR 26504 Patras, Greece
    Anticancer Res 29:349-54. 2009
  6. ncbi A heparin-binding growth factor secreted from breast cancer cells homologous to a developmentally regulated cytokine
    A Wellstein
    V T Lombardi Cancer Center, Georgetown University, Washington, D C 20007
    J Biol Chem 267:2582-7. 1992
  7. ncbi Cloning, characterization and developmental regulation of two members of a novel human gene family of neurite outgrowth-promoting proteins
    P J Kretschmer
    Molecular Biology Research Section, American Cyanamid Company, Lederle Laboratories, Pearl River, New York 10965
    Growth Factors 5:99-114. 1991
  8. ncbi Neurite outgrowth in brain neurons induced by heparin-binding growth-associated molecule (HB-GAM) depends on the specific interaction of HB-GAM with heparan sulfate at the cell surface
    T Kinnunen
    Laboratory of Molecular Neurobiology, University of Helsinki, Finland
    J Biol Chem 271:2243-8. 1996
  9. ncbi High affinity binding and overlapping localization of neurocan and phosphacan/protein-tyrosine phosphatase-zeta/beta with tenascin-R, amphoterin, and the heparin-binding growth-associated molecule
    P Milev
    Department of Pharmacology, New York University Medical Center, New York, New York 10016, USA
    J Biol Chem 273:6998-7005. 1998
  10. pmc Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta
    K Meng
    Division of Growth Regulation, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 97:2603-8. 2000

Research Grants

  1. James T Kadonaga; Fiscal Year: 2015
  2. Structural and functional characterization of the receptor protein tyrosine phosp
    Heidi Erlandsen; Fiscal Year: 2010
  3. Pleiotrophin for Neurorestoration in Parkinson's Disease
    SARA ELIZABETH GOMBASH LAMPE; Fiscal Year: 2013
  4. Harvard/Brown Anxiety Program (HARP)
    Risa B Weisberg; Fiscal Year: 2013
  5. REGULATIOIN OF RENAL PHOSPHATE EXCRETION AND VITAMIN D METABOLISM BY FGF 7
    Rajiv Kumar; Fiscal Year: 2010
  6. DNA elements linking regulation of replication timing to oncogene function
    BENJAMIN DANIEL POPE; Fiscal Year: 2013
  7. Benjamin G Druss; Fiscal Year: 2015
  8. SHEELA VIRENDRA GODBOLE; Fiscal Year: 2014
  9. Articulated Robot for Epicardial Interventions
    Marco A Zenati; Fiscal Year: 2010
  10. IAN MATTHIAS SANNE; Fiscal Year: 2016

Detail Information

Publications213 found, 100 shown here

  1. pmc The survival-promoting peptide Y-P30 enhances binding of pleiotrophin to syndecan-2 and -3 and supports its neuritogenic activity
    Peter Landgraf
    Project Group Neuroplasticity, Leibniz Institute for Neurobiology, Brenneckestrasse 6, Magdeburg 39118, Germany
    J Biol Chem 283:25036-45. 2008
    ..In this study, we identify pleiotrophin (PTN) and syndecan-2 and -3 as direct binding partners of Y-P30...
  2. ncbi Self-association of N-syndecan (syndecan-3) core protein is mediated by a novel structural motif in the transmembrane domain and ectodomain flanking region
    V K Asundi
    Sigfried and Janet Weis Center for Research, Geisinger Clinic, Danville, Pennsylvania 17822 2613, USA
    J Biol Chem 270:26404-10. 1995
    ..This property is similar to the oligomerization activity of other transmembrane receptors and suggests that regulated self-association may be important for the biological activity of transmembrane proteoglycans...
  3. ncbi Bone mass loss due to estrogen deficiency is compensated in transgenic mice overexpressing human osteoblast stimulating factor-1
    H Masuda
    Research Institute for Neurological Diseases and Geriatrics, Second Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, 602, Japan
    Biochem Biophys Res Commun 238:528-33. 1997
    ..These observations indicate that OSF-1 may direct in vivo appositional bone formation by increasing osteoblast activity rather than decreasing osteoclast activity, suggesting a new way to treat osteoporosis with OSF-1...
  4. ncbi Increased keratinocyte proliferation by JUN-dependent expression of PTN and SDF-1 in fibroblasts
    Lore Florin
    Division of Signal Transduction and Growth Control, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Cell Sci 118:1981-9. 2005
    ..mouse embryonic fibroblasts to identify additional players involved in this complex network, and have found pleiotrophin (PTN) and the stromal cell-derived factor 1 (SDF-1) as novel JUN-regulated factors...
  5. ncbi Serum stimulates Pleiotrophin gene expression in an AP-1-dependent manner in human endothelial and glioblastoma cells
    Evangelia Poimenidi
    Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, GR 26504 Patras, Greece
    Anticancer Res 29:349-54. 2009
    Despite the fact that pleiotrophin (PTN) exhibits important biological activities related to tumor growth and angiogenesis, little is known about the regulation of its expression...
  6. ncbi A heparin-binding growth factor secreted from breast cancer cells homologous to a developmentally regulated cytokine
    A Wellstein
    V T Lombardi Cancer Center, Georgetown University, Washington, D C 20007
    J Biol Chem 267:2582-7. 1992
    ..is homologous to a developmentally regulated, neurotrophic factor, heparin-binding growth-associated molecule/pleiotrophin (HB-GAM/PTN; Merenmies, J., and Rauvala, H. (1990) J. Biol. Chem. 265, 16721-16724; Li, Y. S., Milner, P. G...
  7. ncbi Cloning, characterization and developmental regulation of two members of a novel human gene family of neurite outgrowth-promoting proteins
    P J Kretschmer
    Molecular Biology Research Section, American Cyanamid Company, Lederle Laboratories, Pearl River, New York 10965
    Growth Factors 5:99-114. 1991
    ..describes the cloning, expression and characterization of two members of a novel human gene family of proteins, HBNF and MK, which exhibit neurite outgrowth-promoting activity...
  8. ncbi Neurite outgrowth in brain neurons induced by heparin-binding growth-associated molecule (HB-GAM) depends on the specific interaction of HB-GAM with heparan sulfate at the cell surface
    T Kinnunen
    Laboratory of Molecular Neurobiology, University of Helsinki, Finland
    J Biol Chem 271:2243-8. 1996
    ..We suggest that this property of N-syndecan heparan sulfate is essential for HB-GAM binding and induction of neurite outgrowth...
  9. ncbi High affinity binding and overlapping localization of neurocan and phosphacan/protein-tyrosine phosphatase-zeta/beta with tenascin-R, amphoterin, and the heparin-binding growth-associated molecule
    P Milev
    Department of Pharmacology, New York University Medical Center, New York, New York 10016, USA
    J Biol Chem 273:6998-7005. 1998
    ....
  10. pmc Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta
    K Meng
    Division of Growth Regulation, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 97:2603-8. 2000
    b>Pleiotrophin (PTN) is a platelet-derived growth factor-inducible, 18-kDa heparin-binding cytokine that signals diverse phenotypes in normal and deregulated cellular growth and differentiation...
  11. ncbi Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin
    G E Stoica
    Lombardi Cancer Center, Georgetown University, Washington, DC 20007, USA
    J Biol Chem 276:16772-9. 2001
    b>Pleiotrophin (PTN) is a secreted growth factor that induces neurite outgrowth and is mitogenic for fibroblasts, epithelial, and endothelial cells...
  12. ncbi Heparin affin regulatory peptide in milk: its involvement in mammary gland homeostasis
    Isabelle Bernard-Pierrot
    Laboratoire de Recherche sur la Croissance Cellulaire, la Réparation et la Régénération Tissulaires FRE CNRS No 2412, Université Paris Val de Marne Avenue du Général de Gaulle, Creteil, France
    Biochem Biophys Res Commun 314:277-82. 2004
    b>HARP (heparin affin regulatory peptide) is a heparin binding growth factor implicated in cellular growth and differentiation...
  13. ncbi Heparin affin regulatory peptide binds to vascular endothelial growth factor (VEGF) and inhibits VEGF-induced angiogenesis
    Melanie Heroult
    Laboratoire de Recherche sur la Croissance Cellulaire, la Réparation et la Régénération Tissulaires CRRET, FRE CNRS 2412, Université Paris XII Val de Marne, avenue du General de Gaulle, 94010 Creteil, France
    Oncogene 23:1745-53. 2004
    Heparin affin regulatory peptide (HARP) is an heparin-binding molecule involved in the regulation of cell proliferation and differentiation...
  14. ncbi Characterization of heparin affin regulatory peptide signaling in human endothelial cells
    Apostolos Polykratis
    Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, 26504 Patras, Greece
    J Biol Chem 280:22454-61. 2005
    Heparin affin regulatory peptide (HARP) is an 18-kDa secreted growth factor that has a high affinity for heparin and a potent role on tumor growth and angiogenesis...
  15. ncbi Differential induction of glioblastoma migration and growth by two forms of pleiotrophin
    Kan V Lu
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Biol Chem 280:26953-64. 2005
    ..The secreted growth factor pleiotrophin (PTN) promotes glioblastoma migration and proliferation, initiating its oncogenic activities through two cell ..
  16. ncbi Heparin affin regulatory peptide is a key player in prostate cancer cell growth and angiogenicity
    Maria Hatziapostolou
    Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, Greece
    Prostate 65:151-8. 2005
    ..Heparin affin regulatory peptide (HARP) seems to be involved in the progression of several tumors of diverse origin...
  17. ncbi Pleiotrophin induces formation of functional neovasculature in vivo
    Karen L Christman
    University of California Berkeley and San Francisco Joint Bioengineering Graduate Group, USA
    Biochem Biophys Res Commun 332:1146-52. 2005
    b>Pleiotrophin (PTN) is a heparin-binding growth/differentiation inducing cytokine that shares 50% amino acid sequence identity and striking domain homology with Midkine (MK), the only other member of the Ptn/Mk developmental gene family...
  18. ncbi Ribozyme-targeting reveals the rate-limiting role of pleiotrophin in glioblastoma
    Marius Grzelinski
    Department of Pharmacology and Toxicology, Philipps University School of Medicine, Marburg, Germany
    Int J Cancer 117:942-51. 2005
    ..b>Pleiotrophin (PTN, HB-GAM, HBNF, OSF-1) is a secreted growth factor that shows mitogenic, chemotactic and transforming ..
  19. ncbi Role of heparin binding growth factors in nigrostriatal dopamine system development and Parkinson's disease
    Deanna M Marchionini
    Dept Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Brain Res 1147:77-88. 2007
    ..Midkine, pleiotrophin (PTN), and their receptors syndecan-3 and receptor protein tyrosine phosphatase beta/zeta, were highly ..
  20. ncbi A basic peptide derived from the HARP C-terminus inhibits anchorage-independent growth of DU145 prostate cancer cells
    Oya Bermek
    Laboratoire de Recherche sur la Croissance Cellulaire, la Réparation et la Régénération Tissulaires CRRET, CNRS UMR 7149, Universite Paris 12, 61 Avenue du General de Gaulle, 94010 Creteil Cedex, France
    Exp Cell Res 313:4041-50. 2007
    Heparin affin regulatory peptide (HARP) is an 18 kDa heparin-binding protein that plays a key role in tumor growth...
  21. pmc Identification of candidate angiogenic inhibitors processed by matrix metalloproteinase 2 (MMP-2) in cell-based proteomic screens: disruption of vascular endothelial growth factor (VEGF)/heparin affin regulatory peptide (pleiotrophin) and VEGF/Connective
    Richard A Dean
    University of British Columbia, Centre for Blood Research, 4 401 Life Sciences Institute, 2350 Health Sciences Mall, Vancouver, British Columbia, Canada V6T 1Z3
    Mol Cell Biol 27:8454-65. 2007
    ..by MMP-2 was biochemically confirmed, and the cleavage sites in heparin affin regulatory peptide (HARP; pleiotrophin) and connective tissue growth factor (CTGF) were sequenced by matrix-assisted laser desorption ionization-time ..
  22. doi Roles of pleiotrophin in tumor growth and angiogenesis
    Evangelia Papadimitriou
    Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, Patras, Greece
    Eur Cytokine Netw 20:180-90. 2009
    b>Pleiotrophin (PTN) is a heparin-binding growth factor with diverse biological activities, the most studied of these being those related to the nervous system, tumor growth and angiogenesis...
  23. pmc Expression of pleiotrophin in the prostate is androgen regulated and it functions as an autocrine regulator of mesenchyme and cancer associated fibroblasts and as a paracrine regulator of epithelia
    Brigid Orr
    MRC Human Reproductive Sciences Unit, The Queen s Medical Research Institute, Edinburgh, UK
    Prostate 71:305-17. 2011
    Androgens and paracrine signaling from mesenchyme/stroma regulate development and disease of the prostate, and gene profiling studies of inductive prostate mesenchyme have identified candidate molecules such as pleiotrophin (Ptn).
  24. ncbi Cloning and expression of a developmentally regulated protein that induces mitogenic and neurite outgrowth activity
    Y S Li
    Department of Medicine, Jewish Hospital, Washington University Medical Center, St Louis, MO 63110
    Science 250:1690-4. 1990
    ..This protein, previously designated as heparin binding growth factor (HBGF)-8, is now renamed pleiotrophin (PTN) to reflect its diverse activities...
  25. ncbi Isolation of a neuronal cell surface receptor of heparin binding growth-associated molecule (HB-GAM). Identification as N-syndecan (syndecan-3)
    E Raulo
    Laboratory of Molecular Neurobiology, University of Helsinki, Finland
    J Biol Chem 269:12999-3004. 1994
    HB-GAM (heparin binding growth-associated molecule; pleiotrophin) is a secretory, extracellular matrix-associated protein that is strongly expressed in developing nervous tissues and belongs to a novel family of differentiation/growth ..
  26. ncbi Domain structure of pleiotrophin required for transformation
    N Zhang
    Division of Growth Regulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 274:12959-62. 1999
    The pleiotrophin (PTN) gene (Ptn) is a potent proto-oncogene that is highly expressed in many primary human tumors and constitutively expressed in cell lines derived from these tumors...
  27. ncbi Pleiotrophin signaling through anaplastic lymphoma kinase is rate-limiting for glioblastoma growth
    Ciaran Powers
    Lombardi Cancer Center, Department of Oncology, Georgetown University, Washington, DC, 20007, USA
    J Biol Chem 277:14153-8. 2002
    ..We have recently identified anaplastic lymphoma kinase (ALK) as a tyrosine kinase receptor for pleiotrophin, a secreted growth factor that is highly expressed during embryonic brain development and in tumors of the ..
  28. ncbi The pro-angiogenic cytokine pleiotrophin potentiates cardiomyocyte apoptosis through inhibition of endogenous AKT/PKB activity
    Jinliang Li
    Laboratory of Cardiovascular Science, National Institute on Aging, Baltimore, Maryland 21224, USA
    J Biol Chem 282:34984-93. 2007
    b>Pleiotrophin is a development-regulated cytokine and growth factor that can promote angiogenesis, cell proliferation, or differentiation, and it has been reported to have neovasculogenic effects in damaged heart...
  29. ncbi Hydrogen peroxide stimulates proliferation and migration of human prostate cancer cells through activation of activator protein-1 and up-regulation of the heparin affin regulatory peptide gene
    Christos Polytarchou
    Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, GR26504 Patras, Greece
    J Biol Chem 280:40428-35. 2005
    ..Heparin affin regulatory peptide (HARP) seems to be involved in the stimulatory effect of HP, because the latter had no effect on stably transfected LNCaP ..
  30. ncbi The evolution of Arctic marine mammals
    C R Harington
    Canadian Museum of Nature Paleobiology, Ottawa, Ontario K1P 6P4, Canada
    Ecol Appl 18:S23-40. 2008
    ..marine mammals: polar bear (Ursus maritimus), walrus (Odobenus rosmarus), bearded seal (Erignathus barbatus), harp seal (Pagophilus groenlandica), ringed seal (Phoca hispida), bowhead whale (Balaena mysticetus), white whale (..
  31. ncbi Bioaccumulation of PCBs and chlorinated pesticides in seals, fishes and invertebrates from the White Sea, Russia
    Derek Muir
    National Water Research Institute, Environment Canada, Burlington, ON, Canada L7R 4A6
    Sci Total Environ 306:111-31. 2003
    ..related compounds, hexachlorocyclohexanes (HCH) isomers and chlorobenzenes (CBz) were determined in blubber of harp seals (Phoca groenlandica), ringed seals (Phoca hispida) and bearded seals (Eringnathus barbatus) as well as in ..
  32. ncbi Spatial and temporal trends and effects of contaminants in the Canadian Arctic marine ecosystem: a review
    D Muir
    National Water Research Institute, Environment Canada, Burlington, ON, Canada
    Sci Total Environ 230:83-144. 1999
    ..Studies on contaminants in walrus are limited to Foxe Basin and northern Québec stocks, while migratory harp seals have only been studied recently at one location...
  33. ncbi Levels of non-essential elements in muscle from harp seal (Phagophilus groenlandicus) and hooded seal (Cystophora cristata) caught in the Greenland Sea area
    Linn Anne Brunborg
    National Institute of Nutrition and Seafood Research NIFES, P O Box 2029 Nordnes, N 5817 Bergen, Norway
    Sci Total Environ 366:784-98. 2006
    ..mercury toxicity in marine mammals, were measured in muscle, liver and kidney from reproductive active females of harp seal (Phagophilus groenlandicus) and hooded seal (Cystophora cristata) caught in the drift ice between Iceland and ..
  34. ncbi Hematology and serum chemistry of harp (Phoca groenlandica) and hooded seals (Cystophora cristata) during the breeding season, in the Gulf of St. Lawrence, Canada
    France Boily
    Fisheries and Oceans Canada, Maurice Lamontagne Institute, PO Box 1000, Mont Joli, Quebec G5H 3Z4, Canada
    J Wildl Dis 42:115-32. 2006
    Standard hematologic and serum chemistry parameters were determined from 28 harp seals (Phoca groenlandica) and 20 hooded seals (Cystophora cristata) sampled from 6 March 2001 to 13 March 2001 during the breeding season...
  35. ncbi Variability of somatosensory cortical evoked potentials during spinal surgery. Effects of anesthetic technique and high-pass digital filtering
    C J Kalkman
    Department of Anesthesiology, University of Amsterdam, The Netherlands
    Spine (Phila Pa 1976) 16:924-9. 1991
    ..digital filtering on within-patient variability of posterior tibial nerve somatosensory cortical evoked potentials (PTN-SCEP) were compared prospectively in two groups of 20 patients undergoing spinal surgery...
  36. ncbi Arctic marine mammals and climate change: impacts and resilience
    Sue E Moore
    NOAA Alaska Fisheries Science Center, c o Applied Physics Laboratory, University of Washington, 1013 NE 40th Street, Seattle, Washington 98105, USA
    Ecol Appl 18:s157-165. 2008
    ..Nine other species (five cetacean [fin, humpback, minke, gray, and killer whales] and four pinniped [harp, hooded, ribbon, and spotted seals]) seasonally occupy Arctic and subarctic habitats and may be poised to encroach ..
  37. doi Giardia and Cryptosporidium in harp and hooded seals from the Gulf of St. Lawrence, Canada
    A J Appelbee
    World Health Organization Collaborating Centre for the Molecular Epidemiology of Parasitic Infections, Division of Health Sciences, School of Veterinary and Biomedical Sciences, Murdoch University, Murdoch, WA 6150, Australia
    Vet Parasitol 173:19-23. 2010
    ..this study was to determine the prevalence and genotype of Giardia and Cryptosporidium in two species of pinnipeds, harp seal (Phoca groenlandica) and hooded seal (Cystophora cristata), from the Gulf of St. Lawrence, Canada...
  38. ncbi Experimental evidence of seawater drinking in juvenile hooded (Cystophora cristata) and harp seals (Phoca groenlandica)
    I Skalstad
    Department of Arctic Biology, Institute of Medical Biology, , Breivika, Norway
    J Comp Physiol B 170:395-401. 2000
    This study was undertaken to measure whether young harp seals (Phoca groenlandica) and hooded seals (Cystophora cristata) drink seawater and, if so, to investigate how the excess salt load is handled...
  39. ncbi Radiocaesium (137Cs) in marine mammals from Svalbard, the Barents Sea and the North Greenland Sea
    Magnus Andersen
    Norwegian Polar Institute, N 9296, Tromsø, Norway
    Sci Total Environ 363:87-94. 2006
    ..Muscle samples were collected from 12 polar bears, 15 ringed seals, 10 hooded seals, 7 bearded seals, 14 harp seals, one walrus, one white whale and one blue whale in the period 2000-2003...
  40. doi Subcortical somatosensory evoked potentials after median nerve and posterior tibial nerve stimulation in high cervical cord compression of achondroplasia
    Ling Li
    Department of Pediatric Neurology, University Children s Hospital, Mainz, Germany
    Brain Dev 30:499-503. 2008
    ..detect myelopathy we recorded somatosensory evoked potentials after median nerve (MN) and posterior tibial nerve (PTN) stimulation in 77 patients with achondroplasia aged 0.3-17.8 years (mean 2.7 years)...
  41. doi Diastolic suction is impaired by bed rest: MRI tagging studies of diastolic untwisting
    Todd A Dorfman
    Institute for Exercise and Environmental Medicine, 7232 Greenville Ave, Suite 435, Dallas, TX 75231, USA
    J Appl Physiol (1985) 104:1037-44. 2008
    ..maximal untwisting rates of the endocardium, midwall, and epicardium were calculated by Harmonic Phase Analysis (HARP) before and after -6 degrees head-down tilt bed rest for 18 days with (n = 14) and without exercise training (n = ..
  42. ncbi Posterior tibial nerve and median nerve somatosensory evoked potential monitoring during carotid endarterectomy
    Pirjo Manninen
    Department of Anesthesia, Toronto Western Hospital, 399 Bathurst Street, Toronto, Ontario M5T 2S8, Canada
    Can J Anaesth 51:937-41. 2004
    ..This study assessed the usefulness of monitoring the posterior tibial nerve (PTN) SSEP as an adjunct to MNSSEP for detection of cerebral ischemia and as an indicator for the insertion of a shunt ..
  43. ncbi Epizootiology of morbillivirus infection in harp, hooded, and ringed seals from the Canadian Arctic and western Atlantic
    P J Duignan
    Department of Pathology, Ontario Veterinary College, University of Guelph, Canada
    J Wildl Dis 33:7-19. 1997
    Using a virus neutralization technique, we found phocine distemper virus (PDV) antibody in 130 (83% of 157) harp seals (Phoca groenlandica) from the western North Atlantic sampled between 1988 and 1993 inclusive...
  44. ncbi Dietary menhaden, seal, and corn oils differentially affect lipid and ex vivo eicosanoid and thiobarbituric acid-reactive substances generation in the guinea pig
    M G Murphy
    Department of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada
    Lipids 34:115-24. 1999
    ..Young male guinea pigs were fed nonpurified diet (NP), or NP supplemented (10%, w/w) with menhaden fish oil (MO), harp seal oil (SLO), or corn oil (CO, control diet) for 23 to 28 d...
  45. ncbi Detection of sacral sparing in acute spinal cord injury
    S C Schrader
    Northwestern University Medical School, Department of Anesthesia, Chicago, Illinois
    Spine (Phila Pa 1976) 12:533-5. 1987
    Sacral dermatomal-evoked responses (DEP) and posterior tibial nerve (PTN) somatosensory-evoked potentials (SSEP) were recorded 28 hours after gunshot injury to the 12th thoracic vertebra of a 17-year-old male...
  46. ncbi Chronicity, relapse, and illness--course of panic disorder, social phobia, and generalized anxiety disorder: findings in men and women from 8 years of follow-up
    Kimberly A Yonkers
    Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut 06510, USA
    Depress Anxiety 17:173-9. 2003
    ..Data were analyzed from the Harvard/Brown Anxiety Research Program (HARP), a naturalistic, longitudinal study that repeatedly assessed patients at 6 to 12 month intervals over the course ..
  47. ncbi Synthesis and characterization of 2,3-dibromopropyl-2,4,6-tribromophenyl ether (DPTE) and structurally related compounds evidenced in seal blubber and brain
    Roland von der Recke
    Institute of Food Chemistry, University of Hohenheim, Garbenstrasse 28, D 70599 Stuttgart, Germany
    Environ Sci Technol 41:1590-5. 2007
    ..m/z79 and 81), DPTE was the dominating organobromine compound in blubber and brain samples of hooded seals and harp seals (Phoca groenlandica) from the Barents and Greenland Seas...
  48. doi Tarsal tunnel syndrome associated with a neurilemoma in posterior tibial nerve: a case report
    Hakan Boya
    Afyon Kocatepe University, Faculty of Medicine, Department of Orthopaedics and Traumatology, Afyonkarahisar, Turkey
    Foot (Edinb) 18:174-7. 2008
    Compression neuropathy of the posterior tibial nerve (PTN) and its branches in the tarsal tunnel is called tarsal tunnel syndrome (TTS) and has various aetiologies...
  49. ncbi Physiological effects of seawater intake in adult harp seals during phase I of fasting
    P V Storeheier
    Department of Arctic Biology, University of Tromsø, N 9037, Tromsø, Norway
    Comp Biochem Physiol A Mol Integr Physiol 128:307-15. 2001
    Previous studies have shown that harp seals may drink considerable amounts of seawater. The current study was undertaken to study the physiological responses to bolus administration of seawater...
  50. ncbi Chemical analyses of pore water from boreholes USW SD-6 and USW WT-24, Yucca Mountain, Nevada
    In C Yang
    U S Geological Survey, Denver Federal Center, MS 421, Box 25046, CO 80225, USA
    J Contam Hydrol 62:361-80. 2003
    ..in borehole USW SD-6 was extracted from nonwelded units collectively referred to as the Paintbrush Tuff nonwelded (PTn)...
  51. doi Gas bubbles in seals, dolphins, and porpoises entangled and drowned at depth in gillnets
    M J Moore
    Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 025433, USA
    Vet Pathol 46:536-47. 2009
    Gas bubbles were found in 15 of 23 gillnet-drowned bycaught harp (Pagophilus groenlandicus), harbor (Phoca vitulina) and gray (Halichoerus grypus) seals, common (Delphinus delphis) and white-sided (Lagenorhyncus acutus) dolphins, and ..
  52. ncbi Bronchoalveolar lavage and pulmonary histopathology in harp seals (Phoca groenlandica) experimentally infected with Otostrongylus circumlitus
    Caroline Piché
    Faculte de Medecine Veterinaire, Universite de Montreal, 3200 Sicotte St, St Hyacinthe, Quebec J2S 2M2, Canada
    J Wildl Dis 46:409-21. 2010
    The objective of this study was to characterize pathologic changes associated with experimental infection of harp seals (Phoca groenlandica) with the lungworm Otostrongylus circumlitus (Metastrongyloidea: Crenosomatidae)...
  53. ncbi Heparin-binding growth factor, pleiotrophin, mediates neuritogenic activity of embryonic pig brain-derived chondroitin sulfate/dermatan sulfate hybrid chains
    Xingfeng Bao
    Department of Biochemistry, Kobe Pharmaceutical University, Higashinada ku, Kobe 658 8558, Japan
    J Biol Chem 280:9180-91. 2005
    ..However, the neuritogenic mechanism is not well understood. Here we showed that pleiotrophin (PTN), a heparin-binding growth factor, produced mainly by glia cells, was the predominant binding partner for ..
  54. ncbi Seawater drinking restores water balance in dehydrated harp seals
    Ole Jakob How
    Department of Arctic Biology and Institute of Medical Biology, University of Tromsø, Breivika, Tromsø 9037, Norway
    J Comp Physiol B 177:535-42. 2007
    The purpose of this study was to answer the question of whether dehydrated harp seals (Phoca groenlandica) are able to obtain a net gain of water from the intake of seawater...
  55. doi Subcortical somatosensory evoked potentials after posterior tibial nerve stimulation in children
    Rainer Boor
    Department of Pediatric Neurology of the University Children s Hospital, Mainz, Germany
    Brain Dev 30:493-8. 2008
    We report our normative data of somatosensory evoked potentials (SEP) after posterior tibial nerve (PTN) stimulation from a group of 89 children and 18 adults, 0.4-29.2 years of age...
  56. ncbi Glioblastoma and cerebral microvascular endothelial cell migration in response to tumor-associated growth factors
    Marc Alexander Brockmann
    Hans Dietrich Herrmann Laboratory for Brain Tumor Biology, Department of Neurosurgery, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Neurosurgery 52:1391-9; discussion 1399. 2003
    ..Several growth factors are thought to be involved in glioma cell migration; however, little is known about their motogenic potency relative to one another...
  57. doi Brominated flame retardants and organochlorine contaminants in winter flounder, harp and hooded seals, and North Atlantic right whales from the Northwest Atlantic Ocean
    Eric W Montie
    Department of Biology EWM, MJM, and MEH, Woods Hole Oceanographic Institution WHOI, Woods Hole, MA 02543, United States
    Mar Pollut Bull 60:1160-9. 2010
    ..as well as organochlorine (OC) pesticides and polychlorinated biphenyls (PCBs), were measured in winter flounder, harp and hooded seals, and North Atlantic right whales from the Eastern United States and Canada...
  58. ncbi The effect of body fat on basal metabolic rate in adult harp seals (Phoca groenlandica)
    J J Aarseth
    Department of Arctic Biology, University of Tromso, Norway
    Comp Biochem Physiol A Mol Integr Physiol 124:69-72. 1999
    Three adult harp seals (Phoca groenlandica) were fed different daily amounts of capelin (Mallotus villosus), and their body composition determined by use of the tritiated water method at different levels of fattening...
  59. ncbi Transfer of polychlorinated biphenyls and chlorinated pesticides from mother to pup in relation to cytochrome P450 enzyme activities in harp seals (Phoca groenlandica) from the gulf of St. Lawrence, Canada
    Hans Wolkers
    Akvaplan niva, Tromsø, Norway
    Environ Toxicol Chem 21:94-101. 2002
    ..transfer of polychlorinated biphenyls (PCBs) and chlorinated pesticides from female to pup was studied in harp seals from eastern Canada...
  60. ncbi Midkine is a potent regulator of the catecholamine biosynthesis pathway in mouse aorta
    Laura Ezquerra
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, United States
    Life Sci 79:1049-55. 2006
    ..enzymes of catecholamine biosynthesis in aortae of Mk -/- mice were effectively the same as those in aortae of Pleiotrophin (Ptn the gene, PTN the protein) genetically deficient (Ptn -/-) mice when compared with WT (+/+) mice...
  61. doi A microarray based identification of osteoporosis-related genes in primary culture of human osteoblasts
    Zoran Trost
    Chair of Clinical Biochemistry, Faculty of Pharmacy, University of Ljubljana, Askerceva 7, SI 1000 Ljubljana, Slovenia
    Bone 46:72-80. 2010
    ..b>PTN and COL15A1 were both downregulated in osteoporotic bone tissue (6.2- and 3.4-fold, respectively, both p<0...
  62. ncbi Seroprevalence of Toxoplasma gondii in Canadian pinnipeds
    Lena N Measures
    Fisheries and Oceans Canada, Maurice Lamontagne Institute, Mont Joli, Quebec, Canada
    J Wildl Dis 40:294-300. 2004
    Sera (n = 328) collected from phocids (1995-97) from the east coast of Canada, including harp seals (Phoca groenlandica), hooded seals (Cystophora cristata), grey seals (Halichoerus grypus), and harbor seals (Phoca vitulina), were diluted ..
  63. ncbi First United Kingdom Heart and Renal Protection (UK-HARP-I) study: biochemical efficacy and safety of simvastatin and safety of low-dose aspirin in chronic kidney disease
    Colin Baigent
    Clinical Trial Service Unit, Oxford University, Oxford, UK
    Am J Kidney Dis 45:473-84. 2005
    ..Patients with chronic kidney disease are at increased risk for cardiovascular disease, but the efficacy and safety of simvastatin and aspirin are unknown in this patient group...
  64. ncbi Fyn is a downstream target of the pleiotrophin/receptor protein tyrosine phosphatase beta/zeta-signaling pathway: regulation of tyrosine phosphorylation of Fyn by pleiotrophin
    Harold Pariser
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Biochem Biophys Res Commun 332:664-9. 2005
    b>Pleiotrophin (PTN the protein, Ptn the gene) signals downstream targets through inactivation of its receptor, the transmembrane receptor protein tyrosine phosphatase (RPTP)beta/zeta, disrupting the balanced activity of RPTPbeta/zeta and ..
  65. pmc Persistent behavioral alterations in rats neonatally exposed to low doses of the organophosphate pesticide, parathion
    Olga A Timofeeva
    Department of Psychiatry and Behavioral Sciences, Box 3412, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res Bull 77:404-11. 2008
    ..The current study extended investigation to parathion (PTN), an OP that has higher systemic toxicity than either CPF or DZN...
  66. doi Phagocytosis in pup and adult harbour, grey and harp seals
    Heloise Frouin
    Institut National de la Recherche Scientifique Institut Armand Frappier, Laval, Quebec, Canada
    Vet Immunol Immunopathol 134:160-8. 2010
    ..The present study examined the phagocytic activity and efficiency of harbour, grey and harp seal leukocytes...
  67. ncbi A chondroitin sulfate proteoglycan PTPzeta /RPTPbeta regulates the morphogenesis of Purkinje cell dendrites in the developing cerebellum
    Masahiko Tanaka
    Division of Cell Biology, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470 1192, Japan
    J Neurosci 23:2804-14. 2003
    ..phosphatase synthesized as a chondroitin sulfate (CS) proteoglycan, uses a heparin-binding growth factor pleiotrophin (PTN) as a ligand, in which the CS portion plays an essential role in ligand binding...
  68. doi Pleiotrophin is expressed in avian somites and tendon anlagen
    Venugopal Rao Mittapalli
    Department of Molecular Embryology, Institute of Anatomy and Cell Biology, University of Freiburg, Albertstrasse 17, Freiburg 79104, Germany
    Histochem Cell Biol 132:413-22. 2009
    b>Pleiotrophin (Ptn) is a secreted, developmentally regulated growth factor associated with the extracellular matrix...
  69. pmc Ginkgolide B and bilobalide block the pore of the 5-HT₃receptor at a location that overlaps the picrotoxin binding site
    Andrew J Thompson
    Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK
    Neuropharmacology 60:488-95. 2011
    ..5-HT(3)A and 5-HT(3)AB receptors, and compare these to the effects of the structurally related compounds picrotin (PTN) and picrotoxinin (PXN), the two components of picrotoxin (PTX), a known channel blocker of 5-HT(3), nACh and GABA(..
  70. doi PBDEs in serum and blubber of harbor, grey and harp seal pups from Eastern Canada
    Heloise Frouin
    Institut National de la Recherche Scientifique Institut Armand Frappier, Laval, Quebec, Canada H7V 1B7
    Chemosphere 82:663-9. 2011
    Serum and blubber of pup harbor (Phoca vitulina), grey (Halichoerus grypus) and harp (Phoca groenlandica) seals from the Estuary and the Gulf of St. Lawrence were analyzed for polybrominated diphenyl ethers (PBDEs)...
  71. ncbi Melatonin potentiates the vasoconstrictive effect of noradrenaline in renal artery from newborn hooded seals (Cystophora cristata) and harp seals (Phoca groenlandica)
    J J Aarseth
    Department of Arctic Biology and Institute of Medical Biology, University of Tromsø, Norway
    J Comp Physiol B 171:491-6. 2001
    ..in ring segments of the inferior branch of the renal artery from newborn hooded seals (Cystophora cristata, n=6), harp seals (Phoca groenlandica, n=3) and domestic pigs (Sus scrofa f. domestica, n=5)...
  72. ncbi [Rectal cancer staging with endoscopic ultrasonography: correlation with pathological staging]
    J J Vila
    Servicio de Aparato Digestivo, Hospital de Navarra, Pamplona, Spain
    Rev Esp Enferm Dig 99:132-7. 2007
    ..our aim was to evaluate the accuracy of endosonography (EUS) in our experience, to stage rectal cancer...
  73. ncbi A proposed structural basis for picrotoxinin and picrotin binding in the glycine receptor pore
    Zhe Yang
    School of Biomedical Sciences, University of Queensland, Brisbane, Queensland, Australia
    J Neurochem 103:580-9. 2007
    ..GABA(A)Rs) and glycine receptors (GlyRs), is an equimolar mixture of picrotoxinin (PTXININ) and picrotin (PTN)...
  74. ncbi [Final outcome of preterm neonates with and without surgical treatment of patent ductus arteriosus]
    Carlos Antonio Tapia-Rombo
    Servicio de Neonatologia, Hospital General Dr Gaudencio Gonzalez Garza, Centro Medico Nacional La Raza, Instituto Mexicano del Seguro Social, Mexico DF, Mexico
    Gac Med Mex 144:111-20. 2008
    Patent ductus arteriosus (PDA) in the preterm neonate (PTN) with respiratory distress is frequent and there are controversies related to its medical and/or surgical treatment...
  75. doi The systemic angiogenic response during bone healing
    Stefan Weiss
    Department of Orthopaedics, University of Heidelberg, Heidelberg, Germany
    Arch Orthop Trauma Surg 129:989-97. 2009
    ..Delays in bone healing or even nonunion might therefore be associated with altered concentrations of specific angiogenic factors. These alterations might in turn be reflected by changes in serum concentrations...
  76. doi An integrated care facilitation model improves quality of life and reduces use of hospital resources by patients with chronic obstructive pulmonary disease and chronic heart failure
    Stephen Bird
    Health Innovations Research Institute and School of Medical Sciences, RMIT University, PO Box 71, Bundoora, VIC 3083, Australia
    Aust J Prim Health 16:326-33. 2010
    As part of the Department of Human Services Hospital Admissions Risk Program (HARP), a group of acute and community based health care providers located in the western suburbs of Melbourne formed a consortium to reduce the demand on ..
  77. ncbi Neurologic injury after insertion of laminar hooks during Cotrel-Dubousset instrumentation
    H D Been
    Department of Orthopaedic Surgery, Academic Hospital, University of Amsterdam, The Netherlands
    Spine (Phila Pa 1976) 19:1402-5. 1994
    ..All patients were monitored with posterior tibial nerve somatosensory cortical evoked potentials (PTN-SSEPs). CONCLUSION...
  78. ncbi delta-9-Tetrahydrocannabinol regulates gene expression of the growth factor pleiotrophin in the forebrain
    P Mailleux
    Unité de Recherche sur le Cerveau, Faculte de Medecine, Universite Libre de Bruxelles, Brussels, Belgium
    Neurosci Lett 175:25-7. 1994
    ..p.) on gene expression of the growth factor pleiotrophin (PTN) in the adult rat forebrain...
  79. pmc Human trophoblast and choriocarcinoma expression of the growth factor pleiotrophin attributable to germ-line insertion of an endogenous retrovirus
    A M Schulte
    Lombardi Cancer Center, Georgetown University, Washington, DC 20007, USA
    Proc Natl Acad Sci U S A 93:14759-64. 1996
    ..Herein we report that a human endogenous retrovirus (HERV) type C is inserted in the human growth factor gene pleiotrophin (PTN) between the 5' untranslated and the coding region...
  80. ncbi Basic FGF and FGF receptor 1 are expressed in microglia during experimental autoimmune encephalomyelitis: temporally distinct expression of midkine and pleiotrophin
    X Liu
    Laboratory of Experimental Neuropathology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Glia 24:390-7. 1998
    ..assess the expression pattern and possible function in multiple sclerosis, the heparin-binding growth factors pleiotrophin (PTN), midkine (MK), basic fibroblast growth factor (FGF-2) and one of its receptors (FGFR1/flg) mRNA and ..
  81. ncbi Lipid changes and statins in chronic renal insufficiency and dialysis
    C Wanner
    Department of Medicine, Division of Nephrology, University of Wurzburg, Germany
    J Nephrol 14:S76-80. 2001
    ..Large-scale, prospective randomized trials (4D-trial, HARP) are underway to determine whether statins reduce cardiovascular complications in diabetic and non-diabetic ..
  82. ncbi Pleiotrophin (PTN) and midkine (MK) mRNA expression in eutopic and ectopic endometrium in advanced stage endometriosis
    Hye Won Chung
    Department of Obstetrics and Gynecology, Ewha Womans University School of Medicine, Seoul, Korea
    Mol Hum Reprod 8:350-5. 2002
    ..Midkine (MK) and pleiotrophin (PTN) are two related peptides associated with carcinogenesis and angiogenesis...
  83. ncbi Isolation of two cytochrome P450 cDNAs, CYP1A1 and CYP1A2, from harp seal (Phoca groenlandica) and grey seal (Halichoerus grypus)
    Rachel E Tilley
    Centre for Biomolecular Sciences, University of St Andrews, St Andrews, UK
    Comp Biochem Physiol C Toxicol Pharmacol 132:181-91. 2002
    Two cytochrome P450 (CYP), CYP1A1 and CYP1A2, cDNA sequences have been isolated and cloned from harp seal (Phoca groenlandica) and grey seal (Halichoerus grypus)...
  84. ncbi A new porous titanium-nickel alloy: part 2. Sensitization, irritation and acute systemic toxicity evaluation
    Michel Assad
    Biorthex Inc, R and D Biomaterials Department, 9001 Boul L Acadie, Suite 802, Montreal QC H4N 3H5, Canada
    Biomed Mater Eng 12:339-46. 2002
    Porous titanium-nickel (PTN) represents a new biomaterial with orthopedic applications as a long-term implant...
  85. ncbi Synchronization in monkey motor cortex during a precision grip task. II. effect of oscillatory activity on corticospinal output
    Stuart N Baker
    Sobell Department of Neurophysiology, Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom
    J Neurophysiol 89:1941-53. 2003
    ..Coherence was calculated between LFP and PTN discharge. Significant coherence was seen in three bands, with frequencies of 10-14, 17-31, and 34-44 Hz...
  86. ncbi Innocuous jaw movements increase c-fos expression in trigeminal sensory nuclei produced by masseter muscle inflammation
    Jin Y Ro
    Department of Oral and Craniofacial Biological Sciences, University of Maryland Baltimore School of Dentistry, 666 W Baltimore Street, Baltimore, MD 21201, USA
    Pain 104:539-48. 2003
    ..ventral and dorsal regions of the Vc/Vi (subnucleus interpolaris) transition zone, and the paratrigeminal nucleus (PTN)...
  87. ncbi Java-based Open Platform for distributed health telematics applications
    Petra Hoepner
    Fraunhofer Institute FOKUS, Berlin, Germany
    Stud Health Technol Inform 96:73-9. 2003
    Within the European HARP project, a Java-based Open Platform has been specified and implemented to support trustworthy distributed applications for health...
  88. ncbi Effects of pleiotrophin (PTN) over-expression on mouse long bone development, fracture healing and bone repair
    G Li
    Department of Trauma and Orthopaedic Surgery, Queen s University Belfast, Musgrave Park Hospital, Belfast, Northern Ireland, UK
    Calcif Tissue Int 76:299-306. 2005
    b>Pleiotrophin (PTN) was found to have potent effects on regulation of osteoblast recruitment, proliferation and differentiation...
  89. ncbi Relationships among psychosocial functioning, diagnostic comorbidity, and the recurrence of generalized anxiety disorder, panic disorder, and major depression
    Benjamin F Rodriguez
    Department of Psychology, Southern Illinois University, Life Sciences II Room 222A, Carbondale, IL 62901 6502, USA
    J Anxiety Disord 19:752-66. 2005
    ..Participants were part of the Harvard/Brown Anxiety Disorders Research Program (HARP), a naturalistic, prospective, longitudinal study of anxiety disorders in psychiatric outpatients...
  90. ncbi Indirect flat-panel detector with avalanche gain: fundamental feasibility investigation for SHARP-AMFPI (scintillator HARP active matrix flat panel imager)
    Wei Zhao
    Department of Radiology, State University of New York at Stony Brook, L 4, 120 Health Sciences Center Stony Brook, New York 11793 8460, USA
    Med Phys 32:2954-66. 2005
    ..coupling a structured x-ray scintillator CsI(Tl) to an amorphous selenium (a-Se) avalanche photoconductor called HARP (high-gain avalanche rushing photoconductor)...
  91. ncbi Location serves as a conditional cue when harp seals (Pagophilus groenlandicus) solve object discrimination reversal problems
    Stephanie J Walsh
    Department of Psychology, Memorial University of Newfoundland, St John s
    Can J Exp Psychol 61:44-53. 2007
    We examined the capacity of harp seals (Pagophilus groenlandicus) to use spatial context (i.e., their tank) as a conditional cue to solve a two-choice visual discrimination reversal task. Seals were trained to touch one of two 3D objects...
  92. ncbi Does prematurity affect thrombocytopoiesis?
    Alicja Wasiluk
    Department of Neonatology, Medical University, Bialystok, Poland
    Platelets 18:424-7. 2007
    ..A total of 51 preterm newborns (PTN), 25 girls and 26 boys, were recruited for the study...
  93. ncbi Intramedullary stabilization of extraarticular proximal tibial fractures: a biomechanical comparison of intramedullary and extramedullary implants including a new proximal tibia nail (PTN)
    Matthias Hansen
    Clinic for Trauma, Hand, and Reconstructive Surgery, City Hospital, Worms, Germany
    J Orthop Trauma 21:701-9. 2007
    ..To determine in the laboratory whether there are or are not differences between individual geometrical designs of intramedullary and extramedullary devices used for the fixation of extraarticular proximal tibial fractures...
  94. doi Vibrational characteristics of harp soundboards
    Chris Waltham
    Department of Physics and Astronomy, University of British Columbia, Vancouver British Columbia, V6 T 1Z1, Canada
    J Acoust Soc Am 124:1774-80. 2008
    ..This variety presents both a challenge and an opportunity for acousticians. The musical quality of a harp depends on many factors, but key among these is the soundboard...
  95. doi Integrin alpha(v)beta(3) is a pleiotrophin receptor required for pleiotrophin-induced endothelial cell migration through receptor protein tyrosine phosphatase beta/zeta
    Constantinos Mikelis
    Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, GR 26504, Greece
    FASEB J 23:1459-69. 2009
    We have previously shown that the angiogenic growth factor pleiotrophin (PTN) induces migration of endothelial cells through binding to its receptor protein tyrosine phosphatase beta/zeta (RPTPbeta/zeta)...
  96. doi Highly articulated robotic probe for minimally invasive surgery
    Amir Degani
    Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Conf Proc IEEE Eng Med Biol Soc 2008:3273-6. 2008
    We have developed a novel highly articulated robotic probe (HARP) that can thread through tightly packed volumes without disturbing the surrounding tissues and organs. We use cardiac surgery as the focal application of this work...
  97. pmc The Health and Recovery Peer (HARP) Program: a peer-led intervention to improve medical self-management for persons with serious mental illness
    Benjamin G Druss
    Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30316, United States
    Schizophr Res 118:264-70. 2010
    ..Persons with serious mental illnesses (SMI) have elevated rates of comorbid medical conditions, but may also face challenges in effectively managing those conditions...
  98. doi Detection of Cryptosporidium sp. in two new seal species, Phoca vitulina and Cystophora cristata, and a novel Cryptosporidium genotype in a third seal species, Pagophilus groenlandicus, from the Gulf of Maine
    A L Bass
    Center for Land Sea Interactions, University of New England, 11 Hills Beach Road, Biddeford, Maine 04005, USA
    J Parasitol 98:316-22. 2012
    ..in 11 harbor seals (Phoca vitulina), 1 hooded seal (Cystophora cristata), and 1 harp seal (Pagophilus groenlandicus)...
  99. doi Using induced signals to sense position from a microchannel plate detector
    R T Desouza
    Department of Chemistry and Center for Exploration of Energy and Matter, 2401 Milo B Sampson Ln, Bloomington, Indiana 47405, USA
    Rev Sci Instrum 83:053305. 2012
    ..This detector provides sub-millimeter spatial resolution by examining the signal induced on a wire harp by the electron cloud from a microchannel plate detector...
  100. doi Differential phosphoproteome of the striatum from pleiotrophin knockout and midkine knockout mice treated with amphetamine: correlations with amphetamine-induced neurotoxicity
    Esther Gramage
    Pharmacology Lab, Department of Pharmaceutical and Food Sciences, Facultad de Farmacia, Universidad CEU San Pablo, Madrid, Spain
    Toxicology 306:147-56. 2013
    The neurotrophic factors pleiotrophin (PTN) and midkine (MK) have been shown to modulate amphetamine-induced neurotoxicity. Accordingly, PTN-/- and MK-/- mice show an increased vulnerability to amphetamine-induced neurotoxic effects...
  101. doi Comparative study on short- and long-term behavioral consequences of organophosphate exposure: relationship to AChE mRNA expression
    Caridad López-Granero
    Departamento de Psicologia, Universidad de Almeria, Campus de Excelencia Internacional Agroalimentario CEIA3, La Canada, 04120 Almeria, Spain Department of Molecular Pharmacology, Albert Einstein College of Medicine of Yeshiva University, Bronx, 10461 NY, USA
    Neurotoxicology 40:57-64. 2014
    ..5mg/kg diisopropylphosphorofluoridate (DFP) or 15 mg/kg parathion (PTN) was administered to male Wistar rats...

Research Grants59

  1. James T Kadonaga; Fiscal Year: 2015
    ..The study of helicases has been and will continue to be a critically important area of research. The human HARP protein (also known as SMARCAL1 and ATP-dependent ATPase A) was recently found to be an ATP-driven annealing ..
  2. Structural and functional characterization of the receptor protein tyrosine phosp
    Heidi Erlandsen; Fiscal Year: 2010
    ..been described mainly in neuronal cells, and was the first described receptor for the heparin-binding molecule pleiotrophin (PTN), a small chemokine of 15- 17 kDa, that was also independently identified as Osteoblast-stimulating factor-..
  3. Pleiotrophin for Neurorestoration in Parkinson's Disease
    SARA ELIZABETH GOMBASH LAMPE; Fiscal Year: 2013
    ..have shown that viral vector-mediated overexpression in the nigrostriatal system of the neurotrophic factor pleiotrophin (PTN) provides neuroprotection and functional restoration in a 6-hydroxydopamine (6-OHDA) rodent model of PD...
  4. Harvard/Brown Anxiety Program (HARP)
    Risa B Weisberg; Fiscal Year: 2013
    ..In this application we propose two timely and needed studies within the Harvard/Brown Anxiety Research Program (HARP) to address these fundamental gaps in our understanding of the course of anxiety disorders in these understudied ..
  5. REGULATIOIN OF RENAL PHOSPHATE EXCRETION AND VITAMIN D METABOLISM BY FGF 7
    Rajiv Kumar; Fiscal Year: 2010
    ..Our hypothesis is that FGF 7 is a potent PTN that inhibits Wnt signaling, thereby reducing renal Pi reabsorption...
  6. DNA elements linking regulation of replication timing to oncogene function
    BENJAMIN DANIEL POPE; Fiscal Year: 2013
    ..b>Pleiotrophin (PTN) is an oncogene expressed in all malignant gliomas and is transcriptionally regulated during neural ..
  7. Benjamin G Druss; Fiscal Year: 2015
    ..Two pilot tests of this intervention, the Health and Recovery Peer (HARP) program, demonstrated that the program can be implemented with high engagement, retention, and program fidelity, ..
  8. SHEELA VIRENDRA GODBOLE; Fiscal Year: 2014
    ..Prevention of HIV infection [PTN];Optimization of clinical management including co-morbidities [ACTG];Microbicides [MTN] and Vaccine research and ..
  9. Articulated Robot for Epicardial Interventions
    Marco A Zenati; Fiscal Year: 2010
    ..surgery (MICS), we propose to develop and test an innovative approach based on a highly articulated robotic probe (HARP)...
  10. IAN MATTHIAS SANNE; Fiscal Year: 2016
    ..The CTU will link with five leadership networks (ACTG, IMPAACT, Microbicide Network, HVTN and PTN), maximizing scientific and recruitment opportunities by effectively integrating prevention, vaccine and ..
  11. Transfusion Medicine/Hemostasis Clinical Research Network
    Darrell J Triulzi; Fiscal Year: 2012
    ..by applicant) Core Center Program Objectives: The Pittsburgh Transfusion Medicine/Hemostasis Research Network (PTN);an original and active member of the TMH network seeks to continue to contribute to important multicenter clinical ..
  12. Flat-panel X-ray Imaging Detector with Avalanche Gain
    Wei Zhao; Fiscal Year: 2013
    ..CsI) scintillator to convert x-rays to optical photons;an avalanche amorphous selenium (a-Se) photoconductor, HARP (High-gain Avalanche Rushing amorphous Photoconductor), to convert the optical image to charge and provide a ..
  13. Platnesimycin and platencin biosynthesis and engineering in antibacterial drugs
    Ben Shen; Fiscal Year: 2010
    ..The discovery of platensimycin (PTM) and platencin (PTN) as the third entirely new class of antibiotics in the past four decades is therefore of exceptional importance, ..
  14. Long-Gap Nerve Regeneration by Pleiotrophic Support in Multiluminal Grafts
    MARIO IGNACIO ROMERO-ORTEGA; Fiscal Year: 2012
    ..In Specific Aim 1 we will test the regenerative potency of combined Neurotrophin-Pleiotrophin treatment in vitro...
  15. PREDIMAN KRISHAN SHAH; Fiscal Year: 2014
    ..porcine mammary arteries. Pleiotrophin (PTN) gene was found to be specifically expressed in the coronary artery...
  16. Establishing Surveillance of the Pediatric Evidence Base for Drug Therapy
    Kenneth D Mandl; Fiscal Year: 2013
    ..under the Best Pharmaceuticals for Children Act (BPCA) and recently established the Pediatric Trials Network (PTN) to support clinical trials conducted under the BPCA...
  17. HIV PREVENTION TRIALS UNIT-THAILAND
    David Celentano; Fiscal Year: 2006
    ..for participating medical centers; Northern Drug Dependence Treatment Center seek to be a Prevention Trial Network (PTN) Unit for Thailand...
  18. Northern California Pediatrics AIDS Treatment Center
    Diane Wara; Fiscal Year: 2006
    ..Dr. Wara's membership on HIVNET 027 provides linkage with the PTN whereas co-chairing the Vaccine Adolescent Working Group provides linkage with the VTN...
  19. PHOSPHOTONIN--A NOVEL PHOSPHATE REGULATORY HORMONE
    Suzanne Jan de Beur; Fiscal Year: 2003
    ..Tumors associated with OOM secrete a factor, termed phosphatonin (PTN) that inhibits renal proximal tubular reabsorption of phosphate...
  20. Sensitive expression profiling in fixed archived tissue
    Marianna Goldrick; Fiscal Year: 2005
    ..Hybridization Amplification RNase Protection (HARP) uses chimeric DNA/RNA probes, containing RNA complementary to the target adjacent to DNA containing PCR primer ..
  21. Optical Coherence Tomography for Pulmonary Circulation
    Mark Brezinski; Fiscal Year: 2005
    ..Development of an OCT Imaging Catheter, Aim 2. Assessing the Pulmonary Veins Ablation in an Animal Model, Aim 3. Vascular Assessments In Vitro, Aim 4. OCT Elastography and Aim 5. OCT Imaging will be performed in an Animal Model of PTN.
  22. HIV PREVENTION TRIAL UNIT (PRIDE NYC PROGRAM)
    Wafaa El Sadr; Fiscal Year: 2006
    ..of studies in similar groups of participants and have access to large populations appropriate for the proposed PTN studies...
  23. Harp Music: Effects on HRV, Cortisol and Activity
    Kathi Kemper; Fiscal Year: 2006
    ..The purpose of this study is to evaluate the effects of harp music on convalescing premature infants physiologically through heart rate variability (HRV) and salivary cortisol (..
  24. PROTEIN TYROSINE NITRATION IN THE NERVOUS SYSTEM
    ROSARIO TRIFILETTI; Fiscal Year: 1999
    ..evidence that a newly discovered endogenous post-translational protein modification, protein tyrosine nitration, (PTN) results from the action of peroxynitrite- derived nitronium ion (NO2+) upon tyrosine residues...
  25. Inhibition of the ALK Receptor Kinase
    Anton Wellstein; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): The secreted growth factor pleiotrophin (PTN) acts on endothelial as well as epithelial cells and fibroblasts and it can drive tumor growth, angiogenesis, invasion as well as metastasis...
  26. Medical Student Scholars Program at UNC NIDDK Centers
    Robert Sandler; Fiscal Year: 2006
    ..The Program Director, Joyce Harp, MD, is a member of both centers, a faculty member in the Department of Nutrition in the Schools of Medicine and ..
  27. MECHANISMS OF ANGIOGENESIS IN THE FETUS AND NEWBORN
    Peter Milner; Fiscal Year: 1992
    ..This growth factor, termed pleiotrophin (PTN) or heparin-binding growth factor (HBGF)-8, displays extraordinary conservation of cDNA sequence between 3 ..
  28. HARMONIC PHASE MRI FOR ULTRAFAST CARDIAC STRAIN IMAGING
    Jerry Prince; Fiscal Year: 2007
    ..The harmonic phase (HARP) MR imaging approach has been shown to be a flexible, accurate, and robust approach that exploits the concept of MR ..
  29. FUNCTIONAL ROLE OF THE PTN GENE IN VIVO
    Yue Sheng Li; Fiscal Year: 1993
    ..goal of this project is to understand the functional roles of a newly identified growth/differentiation factor, pleiotrophin (PTN) in vivo...
  30. PLEIOTROPHIN REPORTER SYSTEM
    GERARD GRAMINSKI; Fiscal Year: 1999
    b>Pleiotrophin (PAIN) is a cytokine that promotes growth and development. Inappropriate expression of PTN has been shown to result in tumorigenicity which suggests that inhibiting this pathway may be useful chemotherapeutically...
  31. The developmental functions of Pleiotrophin and Midkine
    Jeff Chen; Fiscal Year: 2006
    This project seeks to understand the biological function of signaling molecules Pleiotrophin (PTN) and Midkine (MK). PTN and MK have proposed signaling functions in angiogenesis, oncogenesis, and chemotaxis...
  32. HIV PREVENTION TRIAL UNIT
    David Metzger; Fiscal Year: 2006
    ..as a HIVNET site and with the addition of several key investigators, this application proposes work in three of the PTN scientific areas: l) microbicides; 2) behavioral interventions, and 3) substance related transmission...
  33. NOVEL ANGIOGENIC/HEMATOPOIETIC SIGNALING PATHWAYS
    Harold Pariser; Fiscal Year: 2004
    ..The study will focus on the pleiotrophin (PTN) signaling pathway which has been shown to transform cells and initiate angiogenesis...
  34. Strain-Encoded MR For Direct Imaging of Cardiac Function
    Nael Osman; Fiscal Year: 2006
    ..Our long-term goal will be to compare the clinical sensitivity and specificity of SENC for determining viability against other existing modalities, such as SPECT, PET, or dobutamine stress echo. ..
  35. Intracranial Strain in Mild Traumatic Head Injury
    Philip Bayly; Fiscal Year: 2004
    ..This is an inter-disciplinary project involving impact mechanics, MR tagging, histopathology, and brain injury. ..
  36. Matricellular proteins as regulators of tumor progression
    Rolf A Brekken; Fiscal Year: 2010
    ....
  37. TREATMENT OF SSRI-RESISTANT DEPRESSION IN ADOLESCENTS
    Martin Keller; Fiscal Year: 2006
    ..This site is based in Pittsburgh, which also serves as the Data Coordinating Center for the study [unreadable] [unreadable]..
  38. Identifying Genes Required for Prion Accumulation
    James Stanton; Fiscal Year: 2007
    ..The sponsor collaborates closely in research and has successfully mentored graduate students to research independence. ..
  39. PLEIOTROPHIN SIGNALING MECHANISMS
    THOMAS DEUEL; Fiscal Year: 2002
    b>Pleiotrophin (PTN) is the 17 kD product of a PDGF inducible gene that is up-regulated in response to injury and whose product promotes growth, differentiation and angiogenesis...
  40. PLATELET AND CELL GROWTH--ROLE OF PDGF
    THOMAS DEUEL; Fiscal Year: 2002
    ..these goals, the laboratory has focused on the platelet-derived growth factor (PDGF) and its inducible cytokine pleiotrophin (PTN) as examples of important growth regulatory molecules...
  41. ANXIETY, DISINHIBITION, AND RISK FOR DRUG ABUSE
    Kimberly Yonkers; Fiscal Year: 2003
    ..phenotypic indices of vulnerability using combinations of clinical and psychophysiological measures. ..
  42. DEPRESSIVE DISORDERS IN PRIMARY CARE AND WORK SETTINGS
    Benjamin Druss; Fiscal Year: 2003
    ..This project will compare the impact of depression and three chronic medical illnesses on health costs, absenteeism and job performance ratings both cross-sectionally and over time. ..
  43. Presurgery Hypnosis--Benefits Analysis in Breast Cancer
    Guy Montgomery; Fiscal Year: 2003
    ..The possible mediational role of these factors in hypnosis effects will be examined will classic statistical approaches. ..
  44. DETECTION AND TREATMENT OF POSTPARTUM DEPRESSION
    Kimberly Yonkers; Fiscal Year: 2003
    ..abstract_text> ..
  45. Treating PMS/PMDD--Research versus Clinical Reality
    Kimberly Yonkers; Fiscal Year: 2003
    ....
  46. PLEIOTROPHIN-- AN ANGIOGENIC SWITCH IN TUMOR PROGRESSION
    THOMAS DEUEL; Fiscal Year: 2004
    The long-range goals of this research are to identify and characterize whereby pleiotrophin (PTN) and midkine (MK) signal neovascularization in tumors (i.e...
  47. OXIDASE RELATED 48K PHOSPHOPROTEIN OF HUMAN NEUTROPHILS
    THOMAS DEUEL; Fiscal Year: 2004
    ..The significance of the interaction between p47PH0X and GTP will be studied. Finally, p47PH0X will be crystallized and its structure determined by x-ray analysis. ..
  48. ROLE OF PLEIOTROPHIN IN BREAST CANCER
    THOMAS DEUEL; Fiscal Year: 2004
    The long-range goals of this proposal are to identify and characterize the pathways that are used by pleiotrophin (PTN) and midkine (MK) to promote tumor growth and tumor angiogenesis in human breast cancer models...
  49. Determinants of Bone Strength in Afro-Caribbean Families
    Joseph Zmuda; Fiscal Year: 2004
    ..The identification of these genes will likely yield fundamental insight on bone biology and may lead to the development of novel approaches to the diagnosis, treatment, and prevention of osteoporosis. ..
  50. MOLECULAR PATHOLOGY OF PNEUMOCYSTIS PNEUMONIA
    Chao Hung Lee; Fiscal Year: 2004
    ..carinii-infected lung will also be tested. Any P. carinii or host protein that is found to have the ability to down regulate GATA-2 expression will be identified by sequencing a portion of the protein. ..
  51. Aveolar Macrophage Apoptosis and Pneumocystis
    Chao Hung Lee; Fiscal Year: 2009
    ..abstract_text> ..
  52. Psychosocial Res. to Improve Drug Treatment in Pregnancy
    Kimberly Yonkers; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  53. Effects of Perinatal Depression on PTD and LBW
    Kimberly Yonkers; Fiscal Year: 2008
    ..Further, if we determine antidepressants increase the risk of adverse perinatal outcomes, treatment with psychotherapy rather than antidepressants should be considered when recommending therapeutic options. [unreadable] [unreadable]..
  54. Adapting a Medical Self-Management Program for a Community Mental Health Center
    Benjamin Druss; Fiscal Year: 2008
    ..If successful, it will provide a sustainable, scalable model for improving medical self-management in a highly vulnerable population. ..
  55. REVAMP Follow-Up Study
    Martin Keller; Fiscal Year: 2008
    ....
  56. COLLABORATIVE LONGITUDINAL STUDY OF PERSONALITY DISORDER
    M Shea; Fiscal Year: 2008
    ....
  57. Bone Strength Phenotypes in men: Genes and Environment
    Joseph Zmuda; Fiscal Year: 2008
    ..The improved understanding of the genetic regulation of bone strength that will emerge from the proposed project will yield fundamental insight into the basic mechanisms of male osteoporosis. ..
  58. COLLABORATIVE DEPRESSION STUDY
    Martin Keller; Fiscal Year: 2008
    ..abstract_text> ..
  59. Presurgery Hypnosis in Breast Cancer: Benefits Analysis
    Guy Montgomery; Fiscal Year: 2006
    ..Mediators and moderators (e.g., hypnotizability) of hypnosis effects will be determined, as well as long-term side benefits of the intervention. ..