PTGS2

Summary

Gene Symbol: PTGS2
Description: prostaglandin-endoperoxide synthase 2
Alias: COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2, prostaglandin G/H synthase 2, PGH synthase 2, PHS II, cyclooxygenase 2, cyclooxygenase 2b, prostaglandin H2 synthase 2, prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Species: human

Top Publications

  1. doi Simultaneous modulation of COX-2, p300, Akt, and Apaf-1 signaling by melatonin to inhibit proliferation and induce apoptosis in breast cancer cells
    Jingshu Wang
    State Key Laboratory of Oncology in South China, Sun Yat sen University Cancer Center, Guangzhou, China
    J Pineal Res 53:77-90. 2012
  2. pmc Polymorphisms in the xenobiotic transporter Multidrug Resistance 1 (MDR1) and interaction with meat intake in relation to risk of colorectal cancer in a Danish prospective case-cohort study
    Vibeke Andersen
    Medical Department, Viborg Regional Hospital, DK 8800 Viborg, Denmark
    BMC Cancer 9:407. 2009
  3. pmc Acquired activation of the Akt/cyclooxygenase-2/Mcl-1 pathway renders lung cancer cells resistant to apoptosis
    Wenjie Chen
    Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr, SE, Albuquerque, NM 87108, USA
    Mol Pharmacol 77:416-23. 2010
  4. pmc Cox-2 is regulated by Toll-like receptor-4 (TLR4) signaling: Role in proliferation and apoptosis in the intestine
    Masayuki Fukata
    Inflammatory Bowel Disease Center, Division of Gastroenterology, New York, New York, USA
    Gastroenterology 131:862-77. 2006
  5. pmc Epidermal growth factor-activated aryl hydrocarbon receptor nuclear translocator/HIF-1{beta} signal pathway up-regulates cyclooxygenase-2 gene expression associated with squamous cell carcinoma
    Kwang Yu Chang
    National Institute of Cancer Research, National Health Research Institutes, Tainan 701, Taiwan
    J Biol Chem 284:9908-16. 2009
  6. doi Functional polymorphisms of cyclooxygenase-2 gene and risk for hepatocellular carcinoma
    Hikmet Akkiz
    Department of Gastroenterology, Faculty of Medicine, Cukurova University, 01330, Adana, Turkey
    Mol Cell Biochem 347:201-8. 2011
  7. pmc A common single-nucleotide polymorphism in cyclooxygenase-2 disrupts microRNA-mediated regulation
    A E Moore
    Department of Biological Sciences and Center for Colon Cancer Research, University of South Carolina, Columbia, SC 29208, USA
    Oncogene 31:1592-8. 2012
  8. ncbi Galectin-1 promotes lung cancer progression and chemoresistance by upregulating p38 MAPK, ERK, and cyclooxygenase-2
    Ling Yen Chung
    Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming University, Taipei, Taiwan
    Clin Cancer Res 18:4037-47. 2012
  9. pmc Cyclooxygenase-2, not microsomal prostaglandin E synthase-1, is the mechanism for interleukin-1β-induced prostaglandin E2 production and inhibition of insulin secretion in pancreatic islets
    Susan Parazzoli
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, Washington 98122, USA
    J Biol Chem 287:32246-53. 2012
  10. pmc Integrin α3β1 controls mRNA splicing that determines Cox-2 mRNA stability in breast cancer cells
    Sita Subbaram
    Center for Cell Biology and Cancer Research, Albany Medical College, MC 165, 47 New Scotland Avenue, Albany, NY 12208, USA
    J Cell Sci 127:1179-89. 2014

Research Grants

  1. Eicosanoid regulation of experimental Lyme arthritis
    Charles R Brown; Fiscal Year: 2010
  2. RAYMOND NELSON DUBOIS; Fiscal Year: 2016
  3. William L Smith; Fiscal Year: 2014
  4. COX2 EXPRESSION IN GENITOURINARY CANCER AND DEVELOPMENT
    Matthew Breyer; Fiscal Year: 2001
  5. Prostanoid signaling and inflammation in aging and Alzheimer's disease
    Katrin I Andreasson; Fiscal Year: 2013
  6. Lawrence J Marnett; Fiscal Year: 2016
  7. Claus Schneider; Fiscal Year: 2015
  8. Chemopreventive effect of fish oil derived EPA in lung cancer
    Peiying Yang; Fiscal Year: 2013
  9. (R)-flurbiprofen Substrate-Selective Inhibition of COX-2 and Analog Development
    Daniel Hermanson; Fiscal Year: 2013
  10. NSAID-Phosphatidylcholine Association: Insight in GI Ulcer Pathogenesis/Therapy
    Lenard M Lichtenberger; Fiscal Year: 2010

Detail Information

Publications431 found, 100 shown here

  1. doi Simultaneous modulation of COX-2, p300, Akt, and Apaf-1 signaling by melatonin to inhibit proliferation and induce apoptosis in breast cancer cells
    Jingshu Wang
    State Key Laboratory of Oncology in South China, Sun Yat sen University Cancer Center, Guangzhou, China
    J Pineal Res 53:77-90. 2012
    ....
  2. pmc Polymorphisms in the xenobiotic transporter Multidrug Resistance 1 (MDR1) and interaction with meat intake in relation to risk of colorectal cancer in a Danish prospective case-cohort study
    Vibeke Andersen
    Medical Department, Viborg Regional Hospital, DK 8800 Viborg, Denmark
    BMC Cancer 9:407. 2009
    ....
  3. pmc Acquired activation of the Akt/cyclooxygenase-2/Mcl-1 pathway renders lung cancer cells resistant to apoptosis
    Wenjie Chen
    Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr, SE, Albuquerque, NM 87108, USA
    Mol Pharmacol 77:416-23. 2010
    ..Our results establish a novel pathway that consists of Akt, COX-2, and Mcl-1 for acquired apoptosis resistance, which could be a molecular target for circumventing acquired chemoresistance in lung cancer...
  4. pmc Cox-2 is regulated by Toll-like receptor-4 (TLR4) signaling: Role in proliferation and apoptosis in the intestine
    Masayuki Fukata
    Inflammatory Bowel Disease Center, Division of Gastroenterology, New York, New York, USA
    Gastroenterology 131:862-77. 2006
    ..We wished to test the hypothesis that cyclooxygenase 2 (Cox-2)-derived prostaglandin E2 (PGE2) is important in TLR4-related mucosal repair.
  5. pmc Epidermal growth factor-activated aryl hydrocarbon receptor nuclear translocator/HIF-1{beta} signal pathway up-regulates cyclooxygenase-2 gene expression associated with squamous cell carcinoma
    Kwang Yu Chang
    National Institute of Cancer Research, National Health Research Institutes, Tainan 701, Taiwan
    J Biol Chem 284:9908-16. 2009
    ..Our results revealed that ARNT plays an important role in EGF-regulated COX-2 gene expression and may thus be related to either a cause or a consequence of tumorigenesis in cervical cancer...
  6. doi Functional polymorphisms of cyclooxygenase-2 gene and risk for hepatocellular carcinoma
    Hikmet Akkiz
    Department of Gastroenterology, Faculty of Medicine, Cukurova University, 01330, Adana, Turkey
    Mol Cell Biochem 347:201-8. 2011
    ..However, because this is the first report concerning the COX-2 -1195A>G, -765G>C, and +8473T>C polymorphisms and the risk of HCC, independent studies are needed to validate our findings...
  7. pmc A common single-nucleotide polymorphism in cyclooxygenase-2 disrupts microRNA-mediated regulation
    A E Moore
    Department of Biological Sciences and Center for Colon Cancer Research, University of South Carolina, Columbia, SC 29208, USA
    Oncogene 31:1592-8. 2012
    ..However, the mechanisms allowing for pathogenic COX-2 overexpression are largely unknown. The gene for COX-2 (PTGS2) carries a common single-nucleotide polymorphism (SNP) at position 8473 (T8473C), in exon 10 that is associated ..
  8. ncbi Galectin-1 promotes lung cancer progression and chemoresistance by upregulating p38 MAPK, ERK, and cyclooxygenase-2
    Ling Yen Chung
    Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming University, Taipei, Taiwan
    Clin Cancer Res 18:4037-47. 2012
    ..This study is aimed at investigating the role and novel molecular mechanisms of galectin-1 in lung cancer progression...
  9. pmc Cyclooxygenase-2, not microsomal prostaglandin E synthase-1, is the mechanism for interleukin-1β-induced prostaglandin E2 production and inhibition of insulin secretion in pancreatic islets
    Susan Parazzoli
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, Washington 98122, USA
    J Biol Chem 287:32246-53. 2012
    ..IL-1β inhibited glucose-stimulated insulin secretion equally in both WT and mPGES-1(-/-) islets, indicating that COX-2, not mPGES-1, mediates IL-1β-induced PGE(2) production and subsequent inhibition of insulin secretion...
  10. pmc Integrin α3β1 controls mRNA splicing that determines Cox-2 mRNA stability in breast cancer cells
    Sita Subbaram
    Center for Cell Biology and Cancer Research, Albany Medical College, MC 165, 47 New Scotland Avenue, Albany, NY 12208, USA
    J Cell Sci 127:1179-89. 2014
    ..The induction of cyclooxygenase 2 (Cox-2) by integrin α3β1 in breast cancer cells can promote tumor progression...
  11. pmc Smoking and COX-2 functional polymorphisms interact to increase the risk of gastric cardia adenocarcinoma in Chinese population
    Xue Mei Zhang
    Department of Molecular Biology, College of Life Sciences, Hebei United University, Tangshan, China
    PLoS ONE 6:e21894. 2011
    ..This study aimed to explore the interaction between smoking and functional polymorphisms of COX-2 in modulation of gastric cardia adenocarcinoma (GCA) risk...
  12. pmc COX2 genetic variation, NSAIDs, and advanced prostate cancer risk
    I Cheng
    Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94143 0794, USA
    Br J Cancer 97:557-61. 2007
    Collective evidence suggests that cyclooxygenase 2 (COX2) plays a role in prostate cancer risk. Cyclooxygenase 2 is the major enzyme that converts arachidonic acid to prostaglandins, which are potent mediators of inflammation...
  13. doi UVB irradiation regulates Cox-2 mRNA stability through AMPK and HuR in human keratinocytes
    Jack Zhang
    Arizona Cancer Center, Tucson, Arizona 85724, USA
    Mol Carcinog 47:974-83. 2008
    ..Finally, we propose a novel model in which UVB regulates Cox-2 mRNA stability through the LKB1/AMPK pathway...
  14. doi The expression of both peroxisome proliferator-activated receptor delta and cyclooxygenase-2 in tissues is associated with poor prognosis in colorectal cancer patients
    Masahiro Yoshinaga
    Department of Gastroenterology, Hepatology, and Nutrition, National Hospital Organization Beppu Medical Center, 1473 Uchikamado, Beppu, Oita, 874 0011, Japan
    Dig Dis Sci 56:1194-200. 2011
    ..The role of peroxisome proliferator-activated receptor delta (PPAR δ) in the development and progression of colorectal cancer (CRC) remains controversial...
  15. pmc The mRNA stability factor HuR inhibits microRNA-16 targeting of COX-2
    Lisa E Young
    Department of Biological Sciences and Center for Colon Cancer Research, University of South Carolina, Columbia, SC 29208, USA
    Mol Cancer Res 10:167-80. 2012
    ..Along with insight into altered ARE-mediated mRNA decay observed in colorectal cancer, these findings provide a new explanation for tumor-derived loss of miR-16...
  16. ncbi Potential involvement of the cyclooxygenase-2 pathway in the regulation of tumor-associated angiogenesis and growth in pancreatic cancer
    Jingsong Chu
    Signal Transduction Laboratory, Methodist Research Institute, Indianapolis, Indiana 46202, USA
    Mol Cancer Ther 2:1-7. 2003
    ....
  17. pmc Alternative polyadenylation of cyclooxygenase-2
    Tyra Hall-Pogar
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School Newark, NJ 07101, USA
    Nucleic Acids Res 33:2565-79. 2005
    ..5-fold. Our data suggest for the first time that alternative polyadenylation of COX-2 is an important post-transcriptional regulatory event...
  18. ncbi Increased Leishmania replication in HIV-1-infected macrophages is mediated by tat protein through cyclooxygenase-2 expression and prostaglandin E2 synthesis
    Victor Barreto-de-Souza
    Laboratorio de Imunologia Clinica, Departamento de Imunologia, Rio de Janeiro, RJ, Brazil
    J Infect Dis 194:846-54. 2006
    ..Neutralization of TGF-beta1 reduced parasite growth in Leishmania-infected macrophages exposed to Tat by 50%. Our findings suggest that Tat generates a milieu permissive to Leishmania growth in individuals infected with HIV-1...
  19. pmc Distinct roles of heterogeneous nuclear ribonuclear protein K and microRNA-16 in cyclooxygenase-2 RNA stability induced by S100b, a ligand of the receptor for advanced glycation end products
    Narkunaraja Shanmugam
    Division of Diabetes, Beckman Research Institute of City of Hope, Duarte, California 91010, USA
    J Biol Chem 283:36221-33. 2008
    ..These new results demonstrate that diabetic stimuli can efficiently stabilize inflammatory genes via opposing actions of key RNA-binding proteins and miRs...
  20. pmc Structure of the human cyclo-oxygenase-2 gene
    S B Appleby
    Department of Molecular Biology, Holland Laboratory, American Red Cross, Rockville, MD 20855
    Biochem J 302:723-7. 1994
    ..These efforts serve as a basis for future studies on transcriptional and post-transcriptional mechanisms of Cox-2 gene regulation...
  21. doi Overexpression of COX-2 gene in oral cancer is independent of stage of disease and degree of differentiation
    M Pandey
    Department of Surgical Oncology, Regional Cancer Centre, Trivandrum, Kerala, India
    Int J Oral Maxillofac Surg 37:379-83. 2008
    ..Smokeless tobacco and areca nut chewing is proposed as a possible factor. Cyclooxygenase 2 (COX-2) receptors are present on neoplastic cells and are proposed to participate in initiation, ..
  22. pmc Caveolin-1-mediated suppression of cyclooxygenase-2 via a beta-catenin-Tcf/Lef-dependent transcriptional mechanism reduced prostaglandin E2 production and survivin expression
    Diego A Rodriguez
    Fondo de Investigación Avanzada en Areas Prioritarias, Center for Molecular Studies of the Cell, Departmento de Cirugia, Hospital Clinico, Universidad de Chile, Santiago, Chile
    Mol Biol Cell 20:2297-310. 2009
    ....
  23. doi COX-2 is associated with periodontitis in Europeans
    A S Schaefer
    Christian Albrechts University, Institute for Clinical Molecular Biology, Schittenhelmstrasse 12, 24105 Kiel, Germany
    J Dent Res 89:384-8. 2010
    ..57 (95% confidence interval 1.18-2.08; p = 0.002). The validation of the association of rs20417 by the htSNP rs6681231 provides evidence for a general genetic risk of COX-2 variants in the pathogenesis of periodontitis...
  24. pmc Involvement of Cox-2 in the metastatic potential of chemotherapy-resistant breast cancer cells
    Ju Hee Kang
    Division of Cancer Biology, National Cancer Center, Ilsan ro 323, Ilsandong gu, Goyang si, Gyeonggi do 410 769, Republic of Korea
    BMC Cancer 11:334. 2011
    ..To study the molecular mechanisms underlying the invasive and metastatic activities of drug-resistant cancer cells, we generated a doxorubicin-resistant MCF-7 breast cancer cell line (MCF-7/DOX)...
  25. doi Endothelin-1 enhances cell migration through COX-2 up-regulation in human chondrosarcoma
    Min Huan Wu
    Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan
    Biochim Biophys Acta 1830:3355-64. 2013
    ..The effect of endothelin-1 (ET-1) on migration activity in human chondrosarcoma cells is not clearly understood. Here, we found that ET-1 increased the migration and expression of cyclooxygenase (COX)-2 in human chondrosarcoma cells...
  26. pmc A prospective study of macrophage inhibitory cytokine-1 (MIC-1/GDF15) and risk of colorectal cancer
    Raaj S Mehta
    Affiliations of authors Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA RSM, ATC Gastrointestinal Research Group, Institute of Medical Sciences, Aberdeen University, Aberdeen, United Kingdom NB Department of Epidemiology XG, SO, ELG and Department of Nutrition MS, KW, XG, ELG, Harvard School of Public Health, Boston, MA Department of Pathology, University of Tokyo, Tokyo, Japan TM Channing Division of Network Medicine, Department of Medicine CSF, ELG, ATC and Department of Pathology SO, Brigham and Women s Hospital and Harvard Medical School, Boston, MA Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA CSF, SO
    J Natl Cancer Inst 106:dju016. 2014
    ..Chronic inflammation plays a role in the development of colorectal cancer (CRC). The novel plasma inflammatory biomarker macrophage inhibitory cytokine-1 (MIC-1, GDF15) may have a direct mechanistic role in colorectal carcinogenesis...
  27. ncbi Requirement of cyclooxygenase-2 expression and prostaglandins for human prostate cancer cell invasion
    Kasem Nithipatikom
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Clin Exp Metastasis 19:593-601. 2002
    ..Further, PGD2 may represent a weak inhibitor and counteracts the effect of PGE2 in the cell invasion...
  28. doi Human renal 11beta-hydroxysteroid dehydrogenase 1 functions and co-localizes with COX-2
    Rujun Gong
    Rhode Island Hospital Division of Kidney Diseases and Hypertension, Brown Medical School, Providence, R I, United States
    Life Sci 82:631-7. 2008
    ..Thus, normal human kidney contains active 11beta-HSD1 and 11beta-HSD2. 11beta-HSD1 co-localizes with COX-2 in proximal tubule cells...
  29. pmc Cyclooxygenase in normal human tissues--is COX-1 really a constitutive isoform, and COX-2 an inducible isoform?
    Nina Zidar
    Medical Faculty, Institute of Pathology, University of Ljubljana, Ljubljana, Slovenia
    J Cell Mol Med 13:3753-63. 2009
    ..We may have to revise the concept of 'constitutive' and 'inducible' COX isoforms...
  30. doi Cyclooxygenase polymorphisms in gastric and colorectal carcinogenesis: are conclusive results available?
    Carina Pereira
    Molecular Oncology, Portuguese Institute of Oncology, Porto, Portugal
    Eur J Gastroenterol Hepatol 21:76-91. 2009
    ..Our goal was to understand whether there is a clear role for COX polymorphisms in gastric and colorectal carcinogenesis...
  31. ncbi Protective effect of NSAIDs on cancer and influence of COX-2 C(-765G) genotype
    C Siemes
    Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands
    Curr Cancer Drug Targets 8:753-64. 2008
    ..The aim of this study was to explore the role of cumulative NSAID use on four common non-skin related cancers and modification by COX-2 G(-765)C genotype...
  32. doi Common polymorphisms in the prostaglandin pathway genes and their association with breast cancer susceptibility and survival
    Jean E Abraham
    Cancer Research UK Department of Oncology, University of Cambridge, United Kingdom
    Clin Cancer Res 15:2181-91. 2009
    ..Conflicting data from several studies exist for the association of PTGS2 (cyclooxygenase 2) polymorphisms with breast cancer risk...
  33. pmc MBP-1 suppresses growth and metastasis of gastric cancer cells through COX-2
    Kai Wen Hsu
    Department of Anatomy and Cell Biology, National Yang Ming University, Taipei, Taiwan
    Mol Biol Cell 20:5127-37. 2009
    ..MBP-1 also suppressed epithelial-mesenchymal transition in SC-M1 cells. Additionally, MBP-1 bound on cyclooxygenase 2 (COX-2) promoter and downregulated COX-2 expression...
  34. doi Potentially functional COX-2-1195G>A polymorphism increases the risk of digestive system cancers: a meta-analysis
    Jing Dong
    Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, Nanjing, China
    J Gastroenterol Hepatol 25:1042-50. 2010
    ..The aim of this meta-analysis was to evaluate the association between these three polymorphisms and the risk of cancer in diverse populations...
  35. pmc Upregulation of cyclooxygenase-2 (COX-2) and microsomal prostaglandin E2 synthase-1 (mPGES-1) in wall of ruptured human cerebral aneurysms: preliminary results
    David Hasan
    Department of Neurosurgery, Carver College of Medicine, University of Iowa, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, JCP 1616, Iowa City, IA 52242, USA
    Stroke 43:1964-7. 2012
    ..The upregulation of COX-2/mPGES-1 in the wall of ruptured human cerebral aneurysms is not known...
  36. doi Cyclooxygenase-2 genetic variants are associated with survival in unresectable locally advanced non-small cell lung cancer
    Nan Bi
    Department of Radiation Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Clin Cancer Res 16:2383-90. 2010
    ..This study examined whether genetic variations in the COX-2 gene are associated with different survival in inoperable locally advanced non-small cell lung cancer (NSCLC) treated with chemoradiotherapy or radiotherapy alone...
  37. pmc The hepatitis B virus X protein promotes tumor cell invasion by inducing membrane-type matrix metalloproteinase-1 and cyclooxygenase-2 expression
    Enrique Lara-Pezzi
    Unidad de Biologia Molecular, Hospital Universitario de la Princesa, Madrid, Spain
    J Clin Invest 110:1831-8. 2002
    ....
  38. ncbi Endothelin-1 stimulates cyclooxygenase-2 expression in ovarian cancer cells through multiple signaling pathways: evidence for involvement of transactivation of the epidermal growth factor receptor
    Francesca Spinella
    Laboratory of Molecular Pathology and Ultrastructure, Regina Elena Cancer Institute, Rome, Italy
    J Cardiovasc Pharmacol 44:S140-3. 2004
    ..These results suggest that the pharmacological blocking of endothelin-A receptor is an attractive strategy to control the cyclooxygenase-2 protein expression in ovarian carcinoma...
  39. ncbi Cyclooxygenase-2 regulates survival, migration, and invasion of human endometriotic cells through multiple mechanisms
    S K Banu
    Reproductive Endocrinology and Cell Signaling Laboratory, Department of Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas 77843, USA
    Endocrinology 149:1180-9. 2008
    ..Our results support the emerging concept that COX-2/PGE(2) promotes the pathophysiology and pathogenesis of endometriosis in humans...
  40. doi Cyclooxygenase-2 expression on urothelial and inflammatory cells of cystoscopic biopsies and urine cytology as a possible predictive marker for bladder carcinoma
    Mona Moussa
    Department of Pathology, Theodor Bilhartz Research Institute, Giza, Egypt
    APMIS 117:45-52. 2009
    ....
  41. pmc Defective histone acetylation is responsible for the diminished expression of cyclooxygenase 2 in idiopathic pulmonary fibrosis
    William R Coward
    Division of Respiratory Medicine, City Hospital, University of Nottingham, Hucknall Road, Nottingham, United Kingdom
    Mol Cell Biol 29:4325-39. 2009
    Diminished cyclooxygenase 2 (COX-2) expression in fibroblasts, with a resultant defect in the production of the antifibrotic mediator prostaglandin E(2), plays a key role in the pathogenesis of idiopathic pulmonary fibrosis (IPF)...
  42. doi The contribution of cyclooxygenase-1 and -2 to persistent thromboxane biosynthesis in aspirin-treated essential thrombocythemia: implications for antiplatelet therapy
    Alfredo Dragani
    Department of Hematology, Spirito Santo Hospital, Pescara, Italy
    Blood 115:1054-61. 2010
    We tested whether cyclooxygenase 2 (COX-2) expression and unacetylated COX-1 in newly formed platelets might contribute to persistent thromboxane (TX) biosynthesis in aspirin-treated essential thrombocythemia (ET)...
  43. doi PPARgamma agonists inhibit angiogenesis by suppressing PKCalpha- and CREB-mediated COX-2 expression in the human endothelium
    Egeria Scoditti
    CNR Institute of Clinical Physiology, Lecce, Italy
    Cardiovasc Res 86:302-10. 2010
    ..As a potential mechanism for this, we aimed at examining the effects of PPARgamma agonists on the pro-angiogenic enzyme cyclooxygenase (COX)-2 in human endothelium...
  44. doi Expression of cyclooxygenase-2 in eutopic endometrium and ovarian endometriotic tissue in women with severe endometriosis
    SiHyun Cho
    Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Yonsei University College of Medicine, 146 92 Dogok dong, Gangnam Gu, Seoul, Korea
    Gynecol Obstet Invest 69:93-100. 2010
    ..The purpose of this study is to evaluate the level and pattern of cyclooxygenase-2 (Cox-2) expression in endometriosis and to investigate the correlation between the expression of Cox-2 and several clinicosurgical parameters...
  45. pmc Expression and prognostic significance of Cox-2 and p-53 in Hodgkin lymphomas: a retrospective study
    Nagehan O Barisik
    Pathology Department, Kartal Research and Education Hospital, Istanbul, Turkey
    Diagn Pathol 5:19. 2010
    ..In our study, we examined the association of cox-2 and p53 expression, with age, stage, histopathological subtype, and survival in HL. We also examined correlation between cox-2 and p53 expression...
  46. pmc Honokiol inhibits gastric tumourigenesis by activation of 15-lipoxygenase-1 and consequent inhibition of peroxisome proliferator-activated receptor-gamma and COX-2-dependent signals
    Shing Hwa Liu
    Institute of Toxicology, Taipei, Taiwan
    Br J Pharmacol 160:1963-72. 2010
    ..Here, we investigate the role of 15-LOX-1 induction by honokiol, a small-molecular weight natural product, in PPAR-gamma and COX-2 signalling during gastric tumourigenesis...
  47. pmc Wnt/β-catenin signaling enhances cyclooxygenase-2 (COX2) transcriptional activity in gastric cancer cells
    Felipe Nuñez
    Centro de Tecnología e Innovación para el Cáncer, Department of Biochemistry and Molecular Biology, Faculty of Biological Sciences, Universidad de Concepcion, Concepcion, Chile
    PLoS ONE 6:e18562. 2011
    Increased expression of the cyclooxygenase-2 enzyme (COX2) is one of the main characteristics of gastric cancer (GC), which is a leading cause of death in the world, particularly in Asia and South America...
  48. ncbi The interplay between indoleamine 2,3-dioxygenase 1 (IDO1) and cyclooxygenase (COX)-2 in chronic inflammation and cancer
    A Cesario
    IRCCS San Raffaele Pisana, Rome, Italy
    Curr Med Chem 18:2263-71. 2011
    ..COX-2 inhibition might, in principle, be pursued in cancer-associated inflammation characterized by IDO1 hyper-activity, with the foreseeable aim at altering the immune response within the tumor microenvironment...
  49. doi Expression of COX-2 and E-cadherin in Tunisian patients with colorectal adenocarcinoma
    Imen Miladi-Abdennadher
    Laboratory of Cancer Genetics and Production of Therapeutic Proteins, Center of Biotechnology, Sfax, Tunisia
    Acta Histochem 114:577-81. 2012
    ..006), and in an advanced stage (P=0.001). Survival analysis showed that COX-2 over-expression confers a reduced overall survival rate (Plog rank=0.036) and is an independent factor predictive for prognosis...
  50. ncbi Dynamics of nuclear localization sites for COX-2 in vascular endothelial cells
    H Parfenova
    Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Am J Physiol Cell Physiol 281:C166-78. 2001
    ..COX-2 nuclear localization sites and trafficking between the nucleus and the cytoplasm in endothelial cells may indicate a novel function of COX-2 in regulating gene expression...
  51. pmc Expression of cyclooxygenase 2 is an independent prognostic factor in human ovarian carcinoma
    Carsten Denkert
    Department of Gynecology and Obstetrics, Charite Hospital, Berlin, Germany
    Am J Pathol 160:893-903. 2002
    ..Based on the results of this study, it would be interesting to investigate whether ovarian carcinoma patients with tumors positive for COX-2 would benefit from treatment with selective COX-2 inhibitors...
  52. pmc Dietary omega-3 fatty acids, cyclooxygenase-2 genetic variation, and aggressive prostate cancer risk
    Vincent Fradet
    Departments of Urology, Institute for Human Genetics, University of California at San Francisco, San Francisco, California 94143 0794, USA
    Clin Cancer Res 15:2559-66. 2009
    ..This potential effect may be modified by genetic variation in cyclooxygenase-2 (COX-2), a key enzyme in fatty acid metabolism and inflammation...
  53. doi Vascular endothelial growth factor-C (VEGF-C) promotes angiogenesis by induction of COX-2 in leukemic cells via the VEGF-R3/JNK/AP-1 pathway
    Ming Hsien Chien
    Laboratory of Molecular and Cellular Toxicology, Institute of Toxicology, College of Medicine and Angiogenesis Research Center, National Taiwan University, No 1, Sec 1, Ren Ai Road, Taipei 10016, Taiwan
    Carcinogenesis 30:2005-13. 2009
    ..In sum, the data herein highlight the pathogenic role of VEGF-C in leukemia via regulation of angiogenesis through upregulation of COX-2...
  54. pmc Prognostic Significance and Clinicopathological Associations of COX-2 SNP in Patients with Nonsmall Cell Lung Cancer
    Peter P Grimminger
    Department of General, Visceral and Tumor Surgery, University of Cologne, 50931 Cologne, Germany
    J Oncol 2009:139590. 2009
    ..The results suggest COX-2 926G>C SNP as a molecular marker for lymph node involvement in this disease...
  55. doi The potential predictive value of cyclooxygenase-2 expression and increased risk of gastrointestinal hemorrhage in advanced non-small cell lung cancer patients treated with erlotinib and celecoxib
    Mary J Fidler
    Rush University Medical Center, Chicago, Illinois 60612, USA
    Clin Cancer Res 14:2088-94. 2008
    ..With these observations, we designed a phase II trial to evaluate the efficacy and safety of erlotinib plus celecoxib in advanced NSCLC...
  56. ncbi Common promoter variant in cyclooxygenase-2 represses gene expression: evidence of role in acute-phase inflammatory response
    Anastasia Papafili
    Centre for Respiratory Research, Department of Medicine, Royal Free and University College Medical School, The Rayne Institute, London, UK
    Arterioscler Thromb Vasc Biol 22:1631-6. 2002
    ..Cyclooxygenase (COX)-2 is a key regulatory enzyme in the synthesis of prostanoids associated with trauma and inflammation. We investigated the COX-2 gene for functional variants that may influence susceptibility to disease...
  57. pmc Correlation of COX-2 and Ep-CAM overexpression in human invasive breast cancer and its impact on survival
    G Spizzo
    Division of Haematology and Oncology, University of Innsbruck, Austria
    Br J Cancer 88:574-8. 2003
    Recent studies have demonstrated cyclooxygenase 2 (COX-2) overexpression in various human malignancies, especially in breast cancer, where COX-2 turned out to be a predictor of poor survival...
  58. doi -765G>C and 8473T>C polymorphisms of COX-2 and cancer risk: a meta-analysis based on 33 case-control studies
    Wei Zhu
    Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
    Mol Biol Rep 37:277-88. 2010
    ..In summary, this meta-analysis suggesting that -765G>C may cause an increased risk of colorectal carcinoma and esophageal cancer in Asian descents while 8473T>C polymorphism may cause a decreased risk of breast and lung cancer...
  59. ncbi Characterization of the genomic structure, chromosomal location and promoter of human prostaglandin H synthase-2 gene
    R Tazawa
    Division of Hematology, University of Texas Houston 77030
    Biochem Biophys Res Commun 203:190-9. 1994
    ..Studies of the promoter activity showed that the first 460 nucleotides of 5'-flanking region efficiently drove transcription of the luciferase reporter gene in human umbilical vein endothelial cells upon stimulation with phorbor ester...
  60. ncbi Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines
    D A Jones
    Department of Internal Medicine, University of Utah, Salt Lake City 84112
    J Biol Chem 268:9049-54. 1993
    ..Southern analysis demonstrated a single copy of PHS II and we found a polymorphism in approximately 5% of the population...
  61. doi Cyclooxygenase-2 and Hypoxia-Inducible Factor-1alpha protein expression is related to inflammation, and up-regulated since the early steps of colorectal carcinogenesis
    Francesco Mariani
    Department of Internal Medicine, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100 Modena, Italy
    Cancer Lett 279:221-9. 2009
    ..Neutrophils are a major source of oxidants, whereas cyclooxygenase 2 (COX-2) and Hypoxia Inducible Factor-1alpha (HIF-1alpha) protein expression levels are increased in ..
  62. pmc Prostate tumor growth can be modulated by dietarily targeting the 15-lipoxygenase-1 and cyclooxygenase-2 enzymes
    Uddhav P Kelavkar
    Division of Hematology Oncology and Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Neoplasia 11:692-9. 2009
    ....
  63. pmc Cyclooxygenase-1 is up-regulated in cervical carcinomas: autocrine/paracrine regulation of cyclooxygenase-2, prostaglandin e receptors, and angiogenic factors by cyclooxygenase-1
    Kurt J Sales
    Department of Medical Biochemistry, University of Cape Town Medical School, Cape Town 7925, South Africa
    Cancer Res 62:424-32. 2002
    ..It is likely that similar mechanisms may act in vivo to modulate tumorigenesis of cervical carcinomas...
  64. pmc Polymorphisms in prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/COX2) and risk of colorectal cancer
    D G Cox
    1Genome Analysis Group, International Agency for Research on Cancer, 150 cours Albert Thomas, 69008 Lyon, Cedex 08, France
    Br J Cancer 91:339-43. 2004
    ..We have investigated the relationship between PTGS2 (COX2) polymorphisms and colorectal cancer risk in a hospital based case-control study...
  65. doi Cyclooxygenase-2, multidrug resistance 1, and breast cancer resistance protein gene polymorphisms and inflammatory bowel disease in the Danish population
    Mette Østergaard
    Medical Department, Viborg Regional Hospital, Viborg
    Scand J Gastroenterol 44:65-73. 2009
    ..The purpose of the study was to investigate whether single nucleotide polymorphisms (SNPs) in genes involved in these processes were associated with CD and UC...
  66. doi Up-regulation of inflammatory signalings by areca nut extract and role of cyclooxygenase-2 -1195G>a polymorphism reveal risk of oral cancer
    Shang Lun Chiang
    Graduate Institute of Medicine, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Chung Ho Memorial Hospital, Kaohsiung, Taiwan
    Cancer Res 68:8489-98. 2008
    ....
  67. pmc No association between cyclooxygenase-2 and uridine diphosphate glucuronosyltransferase 1A6 genetic polymorphisms and colon cancer risk
    Cheryl L Thompson
    Department of Family Medicine, Research Division, Case Western Reserve University, 11001 Cedar Ave, Suite 306, Cleveland, Ohio 44106 7136, United States
    World J Gastroenterol 15:2240-4. 2009
    To investigate the association of variations in the cyclooxygenase-2 (COX2) and uridine diphosphate glucuronosyltransferase 1A6 (UGT1A6) genes and non-steroidal anti-inflammatory drugs (NSAIDs) use with risk of colon cancer.
  68. doi COX-2 polymorphisms and colorectal cancer risk: a strategy for chemoprevention
    Carina Pereira
    Portuguese Institute of Oncology, Porto, Portugal
    Eur J Gastroenterol Hepatol 22:607-13. 2010
    ..Therefore, we sought to understand the role of three COX-2 polymorphisms (-1195A>G, -765G>C, and 8473T>C) in colorectal cancer (CRC) onset...
  69. doi Involvement of store-operated calcium signaling in EGF-mediated COX-2 gene activation in cancer cells
    Jaw Yuan Wang
    Division of Gastrointestinal and General Surgery, College of Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    Cell Signal 24:162-9. 2012
    ....
  70. doi Overproduction of cyclo-oxygenase-2 (COX-2) is involved in the resistance to apoptosis in vascular smooth muscle cells from diabetic patients: a link between inflammation and apoptosis
    S Redondo
    Department of Pharmacology, Universidad Complutense, Madrid, Spain
    Diabetologia 54:190-9. 2011
    ..In this work, we investigated whether overproduction of COX-2 was involved in the resistance to apoptosis in VSMC from diabetic patients...
  71. ncbi Expression and localization of cyclooxygenase-1 and -2 in human sporadic amyotrophic lateral sclerosis
    Christian Maihofner
    Department of Neurology, University of Erlangen Nuremberg, Schwabachanlage 6, Erlangen, Germany
    Eur J Neurosci 18:1527-34. 2003
    ..Selective COX-2 inhibition might therefore offer a new possibility in the treatment of human ALS. However, to determine the exact role of COX-2 in human ALS will require further research...
  72. ncbi Cyclooxygenase-2 and gastric carcinogenesis
    Kirsi Saukkonen
    Department of Pathology, Helsinki University, Central Hospital, Helsinki, Finland
    APMIS 111:915-25. 2003
    ..Taken together these data support efforts to initiate clinical studies to investigate the effect of Cox-2 inhibitors as chemotherapeutic agents and as adjuvant treatment modalities against gastric neoplasias...
  73. ncbi Recombinant HBsAg inhibits LPS-induced COX-2 expression and IL-18 production by interfering with the NFkappaB pathway in a human monocytic cell line, THP-1
    Jidong Cheng
    Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine, Hyogo College of Medicine, 1 1 Mukogawacho, Nishinomiya, Hyogo 663, Japan
    J Hepatol 43:465-71. 2005
    ..We investigated whether rHBsAg affects induction of COX-2 and IL-18 by LPS and, if so, which signal pathways are involved in a human monocytic cell line, THP-1...
  74. doi Involvement of Ras and AP-1 in Helicobacter pylori-induced expression of COX-2 and iNOS in gastric epithelial AGS cells
    Soon Ok Cho
    Department of Pharmacology, Brain Korea 21 Project for Medical Sciences, Seoul, 120 752, Korea
    Dig Dis Sci 55:988-96. 2010
    ..In conclusion, H. pylori in a Korean isolate induces the expression of COX-2 and iNOS via AP-1 activation, which may be mediated by Ras and the expression of c-Fos and c-Jun in gastric epithelial cells...
  75. ncbi Nicotinamide phosphoribosyltransferase and prostaglandin H2 synthase 2 are up-regulated in human pancreatic adenocarcinoma cells after stimulation with interleukin-1
    Lukas Bauer
    Institut fur Medizinische Biochemie und Molekularbiologie, Ernst Moritz Arndt Universitat, Greifswald, Germany
    Int J Oncol 35:97-107. 2009
    ..Among them, nicotinamide phosphoribosyltransferase (NAMPT) and prostaglandin H2 synthase 2 (PGHS-2) are crucial proteins whose expression in Colo357 is increased by IL-1...
  76. doi Associations between COX-2 polymorphisms, blood cholesterol and risk of acute coronary syndrome
    Ulla Vogel
    National Food Institute, Technical University of Denmark, Søborg, Denmark
    Atherosclerosis 209:155-62. 2010
    ..The aim of this study was to investigate if the polymorphisms COX2 T8473C (rs5275), and COX2 A-1195G (rs689466), which modify the enzyme levels of COX-2, were associated with risk of ..
  77. doi IL-4 and IL-13 suppress prostaglandins production in human follicular dendritic cells by repressing COX-2 and mPGES-1 expression through JAK1 and STAT6
    Whajung Cho
    Department of Microbiology and Immunology, School of Medicine, Kangwon National University, Chuncheon, Gangwon 200 701, Republic of Korea
    Mol Immunol 48:966-72. 2011
    ..Our results suggest that T cells via IL-4 play a regulatory role in PG generation in FDC. IL-4 therapeutics may be applied to immune disorders where normal and ectopic expression of germinal center reactions needs to be regulated...
  78. doi 15-Deoxy-Delta12,14-prostaglandin J2 induces COX-2 expression through Akt-driven AP-1 activation in human breast cancer cells: a potential role of ROS
    Eun Hee Kim
    National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim Dong, Kwanak gu, Seoul 151 742, South Korea
    Carcinogenesis 29:688-95. 2008
    ..Taken together, these observations suggest that 15d-PGJ(2) produced by COX-2 overexpression may function as a positive regulator of COX-2 in human breast cancer MCF-7 cells...
  79. ncbi Discoidin domain receptor 1 receptor tyrosine kinase induces cyclooxygenase-2 and promotes chemoresistance through nuclear factor-kappaB pathway activation
    Sanjeev Das
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Cancer Res 66:8123-30. 2006
    ..Thus, DDR1 signaling provides a novel target for therapeutic intervention with the prosurvival/antiapoptotic machinery of tumor cells...
  80. pmc Association of polymorphisms in cyclooxygenase (COX)-2 with coronary and carotid calcium in the Diabetes Heart Study
    Megan E Rudock
    From the Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Atherosclerosis 203:459-65. 2009
    ..We sought to determine if variants in the COX-2 gene were associated with subclinical measures of cardiovascular disease in a primarily type 2 diabetic population...
  81. ncbi Regulation of HER-2 oncogene expression by cyclooxygenase-2 and prostaglandin E2
    Valérie Benoit
    Laboratory of Medical Chemistry and Human Genetics, Center for Molecular and Cellular Therapy, University of Liege, Belgium
    Oncogene 23:1631-5. 2004
    ..Therefore, we propose an original model where HER-2 and COX-2 transcriptionally regulate each other in a positive loop...
  82. ncbi Fibronectin stimulates human lung carcinoma cell growth by inducing cyclooxygenase-2 (COX-2) expression
    ShouWei Han
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Int J Cancer 111:322-31. 2004
    ..This work demonstrates that signaling through specific matrix-binding beta1 integrins (i.e., alpha5beta1) resulting from exaggerated deposition in lung of the matrix glycoprotein fibronectin might promote lung carcinoma cell growth...
  83. ncbi COX-2 polymorphism, use of nonsteroidal anti-inflammatory drugs, and risk of colon cancer in African Americans (United States)
    Leah B Sansbury
    Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892 8325, USA
    Cancer Causes Control 17:257-66. 2006
    ..We explored the association between the COX-2 Val511Ala SNP and risk of colon cancer among 240 African American cases and 326 African American controls in a population-based, case-control study in North Carolina...
  84. ncbi [Analysis of HIF-1α and COX-2 expression in tumor stroma and correlation with the degree of neoplasm invasiveness in laryngeal cancer--preliminary study]
    Jan Woś
    Oddział Laryngologii Szpitala im Żeromskiego w Krakowie
    Otolaryngol Pol 65:102-8. 2011
    ....
  85. ncbi Glycosylation regulates turnover of cyclooxygenase-2
    Mary B Sevigny
    Department of Natural Sciences and Mathematics, Dominican University of California, San Rafael, CA 94901, USA
    FEBS Lett 580:6533-6. 2006
    ..Thus, COX-2 turnover appears to depend upon glycosylation of the 72kDa glycoform...
  86. doi Tumor cells induce COX-2 and mPGES-1 expression in microvascular endothelial cells mainly by means of IL-1 receptor activation
    Kelly Casós
    Laboratory of Angiology, Vascular Biology and Inflammation, Institute of Biomedical Research II B Sant Pau, Barcelona, Spain
    Microvasc Res 81:261-8. 2011
    ..HMVEC could therefore contribute directly to PGE(2) formed in the tumor. Our findings support the concept that mPGES-1 could be a target for therapeutic intervention in patients with cancer...
  87. pmc High-density lipoprotein of patients with type 2 diabetes mellitus upregulates cyclooxgenase-2 expression and prostacyclin I-2 release in endothelial cells: relationship with HDL-associated sphingosine-1-phosphate
    Xunliang Tong
    Department of Neurology, Peking University First Hospital, Beijing, China
    Cardiovasc Diabetol 12:27. 2013
    ..However, potential role of HDL and S1P in T2DM remains unexplored. We hypothesized that diabetic HDL with higher contents of S1P exerts beneficial effects on the vascular system...
  88. pmc Corticotropin-releasing hormone interacts with interleukin-1β to regulate prostaglandin H synthase-2 expression in human myometrium during pregnancy and labor
    Danijela Markovic
    Division of Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Coventry CV4 7AL, United Kingdom
    J Clin Endocrinol Metab 98:2864-75. 2013
    ..These responses might involve CRH, which integrates immune and neuroendocrine systems...
  89. ncbi Cellular localization of cyclooxygenase-1 and cyclooxygenase-2 in the normal mouse, rat, and human retina
    Won Kyu Ju
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine St Louis, Missouri 63110, USA
    J Comp Neurol 452:392-9. 2002
    ..These results suggest that prostaglandins, synthesized by COX-1 or COX-2, may contribute to normal physiological and homeostatic functions in the retina...
  90. ncbi PGE(2) is generated by specific COX-2 activity and increases VEGF production in COX-2-expressing human pancreatic cancer cells
    Guido Eibl
    Section of Gastrointestinal Surgery, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, 72 231 CHS, Los Angeles, CA 90095 6904, USA
    Biochem Biophys Res Commun 306:887-97. 2003
    ..These data identify a subset of human PaCa cell lines that express functional COX-2 enzyme. PGE(2) generated by specific COX-2 activity increases VEGF secretion in human PaCa cells through an autocrine mechanism...
  91. pmc Nitroarachidonic acid, a novel peroxidase inhibitor of prostaglandin endoperoxide H synthases 1 and 2
    Andrés Trostchansky
    Departamento de Bioquímica and Center for Free Radical and Biomedical Research, Facultad de Medicina, Montevideo, Uruguay
    J Biol Chem 286:12891-900. 2011
    ..In activated human platelets, AANO(2) significantly decreased PGHS-1-dependent thromboxane B(2) formation in parallel with a decrease in platelet aggregation, thus confirming the biological relevance of this novel inhibitory pathway...
  92. doi A novel single nucleotide polymorphism of the cyclooxygenase-2 gene associated with breast cancer
    F Li
    General Surgery Department, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
    Clin Oncol (R Coll Radiol) 21:302-5. 2009
    ..The gene for COX-2, designated as PTGS2, carries several polymorphisms, such as -765G >C, 1195G/A in the promoter region, and 8473T >C in the 3' UTR,..
  93. doi Impact of COX-2 rs5275 and rs20417 and GPIIIa rs5918 polymorphisms on 90-day ischemic stroke functional outcome: a novel finding
    Jane Maguire
    School of Medicine and Public Health, Faculty of Health, University of Newcastle, Callaghan, New South Wales, Australia
    J Stroke Cerebrovasc Dis 20:134-44. 2011
    ..96; 95% CI = 1.03-3.72; P = .040). This is the first study to demonstrate associations between stroke functional outcome and 2 COX-2 variants (rs20417 and rs5275) and a GPIIIa variant (rs5918)...
  94. doi Human immunodeficiency virus type 1 clade B and C gp120 differentially induce neurotoxin arachidonic acid in human astrocytes: implications for neuroAIDS
    Thangavel Samikkannu
    Department of Immunology, Institute of Neuroimmune Pharmacology, Herbert Wertheim College of Medicine, Florida International University, 11200 S W 8th Street, HLS 1 418A, Miami, FL 33199, USA
    J Neurovirol 17:230-8. 2011
    ..These studies suggest that HIV-1 clade B and C gp120 proteins may play a differential role in the neuropathogenesis of HAD in neuroAIDS...
  95. pmc Cyclic AMP increases COX-2 expression via mitogen-activated kinase in human myometrial cells
    Li Chen
    Academic Department of Obstetrics and Gynaecology, Imperial College School of Medicine, Chelsea and Westminster Hospital, London, UK
    J Cell Mol Med 16:1447-60. 2012
    ..These data provide further evidence in support of a dual role for cAMP in the regulation of myometrial function...
  96. pmc Globular adiponectin counteracts VCAM-1-mediated monocyte adhesion via AdipoR1/NF-κB/COX-2 signaling in human aortic endothelial cells
    Francesco Addabbo
    Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Bari, Italy
    Am J Physiol Endocrinol Metab 301:E1143-54. 2011
    ....
  97. pmc Regulation of cyclooxygenase-2 expression by heat: a novel aspect of heat shock factor 1 function in human cells
    Antonio Rossi
    Institute of Translational Pharmacology, CNR, Rome, Italy
    PLoS ONE 7:e31304. 2012
    ..The results identify COX-2 as a human non-classical heat-responsive gene, unveiling a new aspect of HSF1 function...
  98. ncbi Distinct expression of cyclooxygenase-1 and -2 in the human thymus
    Bianca Rocca
    Department of Internal Medicine, Catholic University School of Medicine, Rome, Italy
    Eur J Immunol 32:1482-92. 2002
    ....
  99. doi Cyclooxygenase-2 (COX-2) inhibition constrains indoleamine 2,3-dioxygenase 1 (IDO1) activity in acute myeloid leukaemia cells
    Maria Grazia Iachininoto
    Department of Haematology, Catholic University Medical School, Largo A Gemelli 8, 00168 Rome, Italy
    Molecules 18:10132-45. 2013
    ..Overall, these data point to COX-2 inhibition as a potential strategy to be pursued with the aim at circumventing leukaemia-induced, IDO-mediated immune dysfunction...
  100. ncbi A polymorphism in the cyclooxygenase 2 gene as an inherited protective factor against myocardial infarction and stroke
    Francesco Cipollone
    G d Annunzio University of Chieti and G d Annunzio University Foundation, Chieti, Italy
    JAMA 291:2221-8. 2004
    ..Production of macrophage MMP-2 and MMP-9 is induced by cyclooxygenase 2 (COX-2) and prostaglandin E(2) synthesis...
  101. ncbi The cyclooxygenase-2 (PTGS2) 8473T>C polymorphism is associated with breast cancer risk
    Uwe Langsenlehner
    Department of Internal Medicine, Medical University of Graz, Graz, Austria
    Clin Cancer Res 12:1392-4. 2006
    ..The gene for COX-2, designated as PTGS2, carries a common polymorphism at position 8473 in the 3'-untranslated region (PTGS2 8473T>C), which has been ..

Research Grants113 found, 100 shown here

  1. Eicosanoid regulation of experimental Lyme arthritis
    Charles R Brown; Fiscal Year: 2010
    ..This information will further our understanding of how inflammation is regulated and allow the design of more effective anti-inflammatory treatments. ..
  2. RAYMOND NELSON DUBOIS; Fiscal Year: 2016
    ..Defining the role of sphingolipid mediators in intestinal tumorigenesis and 4) Investigating the role of Pten-Cox2-mTOR signaling in endometrial cancer...
  3. William L Smith; Fiscal Year: 2014
    ....
  4. COX2 EXPRESSION IN GENITOURINARY CANCER AND DEVELOPMENT
    Matthew Breyer; Fiscal Year: 2001
    ..The discovery of COX2, a second, mitogen inducible isoform, occurred almost simultaneously with realization that patients taking ..
  5. Prostanoid signaling and inflammation in aging and Alzheimer's disease
    Katrin I Andreasson; Fiscal Year: 2013
    ..Our findings will be relevant to the development of novel therapeutic strategies targeting pro- inflammatory pathways in AD. ..
  6. Lawrence J Marnett; Fiscal Year: 2016
    ..These substrate-selective inhibitors may represent candidate cancer chemopreventive agents that lack the gastrointestinal and cardiovascular side effects of currently marketed NSAIDs. ..
  7. Claus Schneider; Fiscal Year: 2015
    ..Novel therapeutic applications of available anti- inflammatory medications are imminent. ..
  8. Chemopreventive effect of fish oil derived EPA in lung cancer
    Peiying Yang; Fiscal Year: 2013
    ..This proposal intends to define a novel targeted natural chemopreventive agent against lung cancer. ..
  9. (R)-flurbiprofen Substrate-Selective Inhibition of COX-2 and Analog Development
    Daniel Hermanson; Fiscal Year: 2013
    ..The drugs may also be applicable to treatment of several prevalent medical conditions that endocannabinoids have been shown to play a role including Alzheimer's disease, drug dependency, obesity, and depression. ..
  10. NSAID-Phosphatidylcholine Association: Insight in GI Ulcer Pathogenesis/Therapy
    Lenard M Lichtenberger; Fiscal Year: 2010
    ..Furthermore, by pre-associating soy PC with NSAIDs we have developed a novel family GI-safer, therapeutically effective PC-NSAIDs that can be made available to the public using an accelerated FDA regulatory pathway. ..
  11. Novel Mechanisms of NSAID-induced GI Toxicity
    James D Lillich; Fiscal Year: 2012
    ..This research may help reduce or eliminate the loss of billions of dollars per year due to medical complications resulting from NSAID-induced GI toxicity. ..
  12. Prostaglandin E2 Signaling in Growth and Pains of Endometriosis
    Joe A Arosh; Fiscal Year: 2012
    ..This is a R21 application addresses the mission of NIH/NICHD on women's reproduction health. ..
  13. Mechanisms of Triterpenoids in Prevention of Prostate Cancer
    Subhash C Gautam; Fiscal Year: 2011
    ....
  14. ChemR23 agonists for pain and inflammation
    Miguel Garcia-Guzman; Fiscal Year: 2011
    ..Narcotics pose a problem of addiction and safety risk while other types of analgesics (e.g. NSAIDs, COX2 inhibitors, antidepressants and anti-epileptics) are hampered by limited efficacy and acute or long-term side ..
  15. Larisa Nonn; Fiscal Year: 2014
    ..We propose a bedside-to-bench approach to first quantify the key genes and microRNAs in stromal tissue then assess these inflammatory mediators in a relevant in vitro model. ..
  16. Clinical Evaluation of GI Safer Naproxen for the Treatment of Osteoarthritis
    UPENDRA K MARATHI; Fiscal Year: 2010
    ....
  17. Anti-inflammatory mechanisms, pharmacokinetics of novel metabolites of vitamin E
    Qing Jiang; Fiscal Year: 2012
    ..The proposed studies will elucidate mechanisms of anti-inflammatory action and generate important preclinical data that are needed to insure maximally informative clinical efficacy studies on these compounds. ..
  18. CHONDROPROTECTIVE ACTIVITY OF POMEGRANATE EXTRACT
    Tariq M Haqqi; Fiscal Year: 2010
    ..Our findings are likely to open the door for the development of novel therapeutic strategies for the treatment of OA. ..
  19. Flavonoids, esophageal/gastric cardia adenocarcinoma and Barretts Esophagus Risk
    Marilie D Gammon; Fiscal Year: 2013
    ..This would allow some EA and GCA to be prevented before individuals develop these lethal cancers. ..
  20. Chemopreventive Effect of NSAIDs Against Prostate Cancer
    Bhagavathi Narayanan; Fiscal Year: 2009
    ..Clear delineation of the chemopreventive efficacy of celecoxib and exisulind in this preclinical model of prostate cancer will allow the rational design of human clinical trials. ..
  21. Type II 11B-Hydroxysteroid Dehydrogenase and Colorectal Tumorigenesis
    Mingzhi Zhang; Fiscal Year: 2013
    ..abstract_text> ..
  22. Mechanisms for NSAID Alzheimer Prevention
    Gregory M Cole; Fiscal Year: 2013
    ..abstract_text> ..
  23. Tianxin Yang; Fiscal Year: 2014
    ..New information resulted from this proposal will help define PGE cascades in the control of ECFV. ..
  24. Development of a novel agent for lung cancer prevention
    Arun Kumar Sharma; Fiscal Year: 2013
    ..Long term, validation of p-XS- Asp as an effective and safe agent would reduce the chances of developing lung cancer, particularly, in smokers/former smokers thereby directly decreasing the mortality incidence. ..
  25. Gary A Piazza; Fiscal Year: 2015
    ..abstract_text> ..
  26. KUMBLE SANDEEP PRABHU; Fiscal Year: 2015
    ..Our long-term goal is to understand the health benefits of bioactive metabolites of ?-3 fatty acids and translate these findings in CML patients. ..
  27. PC-NSAIDs for Chemoprevention of Colorectal Cancer
    Lenard M Lichtenberger; Fiscal Year: 2013
    ....
  28. Opiod Analgesics and the Risk of Serious Infections in Seniors
    Carlos G Grijalva; Fiscal Year: 2013
    ....
  29. Prevention of Alzheimer Dementia and Cognitive Decline
    John C S Breitner; Fiscal Year: 2010
    ....
  30. Cyclooxygenase-2 Inhibition, Angiogenesis, Breast Cancer
    Susan Lanza Jacoby; Fiscal Year: 2003
    ..The COX-1 form is constitutive while COX 2 is inducible and overexpressed in human breast tumors, breast cancer cell lines, and rodent mammary tumors...
  31. John P Lynch; Fiscal Year: 2016
    ..will be tested by the following inter-related Specific Aims: 1) Does chronic Cox-2 activity in the esophagus of K14-Cox2 mice result in inflammation, oxidative stress, DNA damage, and the adoption of an altered differentiation program? ..
  32. Regulation of Neutrophilic Lung Inflammation
    John W Christman; Fiscal Year: 2013
    ..The purpose of this research is to define the basic molecular mechanisms that regulate macrophage involvement in ARDS in order to design new and effective treatments. ..
  33. Eicosanoid Regulation in Atherosclerosis: Involvement of Inducible NO Synthase
    David P Hajjar; Fiscal Year: 2010
    ....
  34. Cyclooxygenase-2 Induced Pancreatic Cancer
    Susan M Fischer; Fiscal Year: 2012
    ....
  35. Role of T cells and PPARgamma in Graves' orbital fibroblast adipogenesis
    Richard P Phipps; Fiscal Year: 2010
    ..This new information will permit the development of new approaches to control inflammation and the pathologic differentiation of orbital fibroblasts important for TAO and other diseases that involve fat deposition. ..
  36. Aaron M Rowland; Fiscal Year: 2014
    ..These studies have the potential to alter current research, and potential future clinical, paradigms. ..
  37. Prostanoid-dependent abdominal aortic aneurysm formation
    Charles Loftin; Fiscal Year: 2010
    ..Therefore, we will use an animal model of this disease to determine the mechanisms by which this disease occurs in humans. These studies are important as they will help identify non-surgical treatments for this disease in humans. ..
  38. Noel G Carlson; Fiscal Year: 2014
    ..target that has been shown to play a major role in neuroinflammation and neuronal loss is the enzyme cyclooxygenase 2 (COX-2) which catalyzes the rate- limiting step in the synthesis of prostanoids...
  39. PAIN EVOKED RELEASE OF AMINO ACIDS AND PROSTANOIDS
    Tony L Yaksh; Fiscal Year: 2012
    ..that one component of this facilitation arises from lipid mediator release by a constitutively active P38MAPK-PLA2-COX2 cascade...
  40. Validation of the PGE2 EP4 receptor as a therapeutic target in AD
    Katrin I Andreasson; Fiscal Year: 2010
    ..Successful target validation of the EP4 receptor will provide the rationale for future and expanded pre-clinical assessment of agonists of this receptor in AD. ..
  41. The role of Prostaglandin E2 in Angiotensin II-induced vascular disease
    Victoria L King; Fiscal Year: 2012
    ....
  42. Raymond Harris; Fiscal Year: 2016
    ..It is hoped that such studies may lead to targeted therapeutic options with a favorable risk-benefit profile that can prevent or slow the development of diabetic nephropathy. ..
  43. LAURA ELIZABETH FREDENBURGH; Fiscal Year: 2016
    ....
  44. Mohammad Athar; Fiscal Year: 2015
    ..However, blocking either one of these molecular targets only partially blocks the development of NMSCs. This proposal attempts to block both of these molecular targets to abrogate the pathogenesis of the most common human cancer, NMSCs. ..
  45. Studies of Eicosanoid Biosynthetic Proteins
    Wonhwa Cho; Fiscal Year: 2013
    ..This timely and critical information will accelerate development and evaluation of new therapeutic agents for inflammatory diseases, cardiovascular diseases, and cancer. ..
  46. Raymond Harris; Fiscal Year: 2016
    ..The physiologic and pathophysiologic interactions of these systems, the intrarenal dopaminergic system, the renin angiotensin system and the cyclooxygenase-2 system, are the focus of the proposed studies. ..
  47. COX2-Derived Cyclopentenone Prostaglandins Exacerbate Hypoxic Ischemic Brain Inju
    Robert W Hickey; Fiscal Year: 2010
    ..We will use a rodent model mimicking pediatric cardiac arrest secondary to mechanisms such as drowning. The project has potential to identify therapies for brain injury in children suffering from cardiac arrest. ..
  48. MRP4 IN DRUG SENSITIVITY AND PHYSIOLOGY
    John D Schuetz; Fiscal Year: 2012
    ..The proposed studes are supported by preliminary data from the Mrp4-/- and Mrp4+/+ mice and are of direct human relevance. ..
  49. Steven H Graham; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Secondary prostaglandin metabolites produced by activation of cyclooxygenase 2 (COX2) after ischemia such as the cyclopentenone prostaglandins (CyPGs) may produce neuronal cell death...
  50. Breast Cancer Survival: Lifestyle and Genetic Determinants
    Xiao Ou Shu; Fiscal Year: 2010
    ..4) The cyclooxygenase-2 (COX2) gene is up-regulated in a large proportion of mammary tumors, and this enzyme initiates the biosynthesis of ..
  51. Role of COX-2 in UVB-induced beta-catenin signaling in keratinocytes
    Jill C Pelling; Fiscal Year: 2011
    ..Demonstrating the existence of a "UVB/COX-2/[unreadable]-catenin axis" in epidermis and identifying its contribution to skin carcinogenesis would have significant impact in the fields of normal skin biology and skin cancer. ..
  52. Carol C Pilbeam; Fiscal Year: 2016
    ..The possibility that manipulation of endogenous PGs might increase the anabolic effects of PTH could have clinical applications. ..
  53. Robert Spurney; Fiscal Year: 2014
    ..found that Gq dependent CN activation promotes podocyte apoptosis, in part, by induction of the CN responsive gene COX2. Based on these observations, we hypothesized that Gq-coupled signaling cascades are important mediators of ..
  54. Altered Arachidonic Acid Balance and Colon Cancer
    DANIEL WILLIAM ROSENBERG; Fiscal Year: 2010
    ..Our goal would be to improve targeting of individuals most likely to respond to chemopreventive agents that impact the AA metabolic pathway. ..
  55. Function of RUNX transcription factors in COCs
    Misung Jo; Fiscal Year: 2013
    ..We also found that RUNX1 and RUNX2 regulate the expression of Ptgs2 (a rate-limiting enzyme in the biosynthesis of prostaglandins) and Hapln1 (a stabilizer of cumulus matrix) in ..
  56. Eicosanoids and Intestinal Epithelial Growth Regulation
    RAYMOND NELSON DUBOIS; Fiscal Year: 2012
    ..It is becoming clear that just targeting one single molecule will not be as effective as needed to have a significant impact on this disease. ..
  57. Role of cPLA2 in Lung Cancer: Microenvironment vs Tumor Cells
    Raphael A Nemenoff; Fiscal Year: 2010
    ..These studies will provide a better understanding of tumor-stromal interactions critical for metastasis and define therapeutic targets to block progression of lung cancer. ..
  58. PROSTAGLANDINS IN EPITHELIAL INJURY
    William F Stenson; Fiscal Year: 2013
    ..3) To define the potential role of exogenous HA as a preventive or therapeutic pharmacologic agent in models of gastrointestinal injury including DSS colitis and radiation injury in the small intestine. ..
  59. Prostaglandin Synthesis and Action in the Primate Corpus Luteum
    Jon D Hennebold; Fiscal Year: 2010
    ..preliminary data have demonstrated that the expression of PGE2 synthesis (prostaglandin-endoperoxide synthase 2 or PTGS2;microsomal PGE2 synthase-1 or PTGES) and signaling (PGE2 receptor 3 or PTGER3) components peak in the rhesus ..
  60. Role of Cyclooxygenase-2-derived Prostanoids in Polymicrobial Sepsis
    LAURA ELIZABETH FREDENBURGH; Fiscal Year: 2012
    ..The main goal of this proposal is to determine how the COX-2 enzyme is protective during sepsis with the hope that this research will eventually lead to new therapies for this frequently fatal disease. ..
  61. Sachin Patel; Fiscal Year: 2016
    ....
  62. PGE2 and PTH effects on osteoblasts
    KATHERINE ANNE BLACKWELL; Fiscal Year: 2010
    ..Our goal is to study the role of cyclooxygenase-2 derived, endogenous prostaglandins and parathyroid hormone in the regulation of osteoblast and osteoclast differentiation to identify new targets for improved therapies. ..
  63. IMAGING COX-2 GENE EXPRESSION IN INFLAMMATION AND TUMORS
    Harvey Herschman; Fiscal Year: 2009
    ..Studies with this mouse will correlate optical and microPET imaging technologies. ..
  64. Harvey J Murff; Fiscal Year: 2014
    ..We anticipate that fish oil will have anti-neoplastic effect and individuals with low FADS1 activity will have a greater response compared to individuals with high FADS1 activity. ..
  65. COX GENE REGULATION IN INTESTINAL MYOFIBROBLASTS
    Don Powell; Fiscal Year: 2009
    ..abstract_text> ..
  66. JAMES CHRISTOPHER BONNER; Fiscal Year: 2016
    ..The broad impact of this work will directly affect the health and well-being of millions of individuals in the U.S. and worldwide by providing essential information for the design of safer nanomaterials. ..
  67. Ligand Directed Transdermal siRNA Delivery to Improve Wound Healing
    David M Evans; Fiscal Year: 2012
    ..The outcome of this project will be the initial characterization of a valuable therapeutic option for treatment of patients with various types of skin wounds. ..
  68. Xianglin Shi; Fiscal Year: 2015
    ..C3G), a compound found in blackberries and other foods, show that this compound is able to inhibit NF-:B, AP-1, COX2, and TNF1 activation/expression, neoplastic transformation, cancer cell migration and invasion, and induction of ..
  69. Howard B Lieberman; Fiscal Year: 2016
    ....
  70. Iman Hassan; Fiscal Year: 2014
    ..increased pro-inflammatory cytokine release and increased expression of prostaglandin-endoperoxide synthase 2 (PTGS2), matrix metalloproteinases (MMPs) and redox- sensitive genes in human placental trophoblasts (HTR-8/SVneo cell ..
  71. Tatiana Efimova; Fiscal Year: 2014
    ..tumor promotion by TPA, and the TPA-mediated induction of key inflammatory and angiogenic mediators, including COX2, VEGF1, and AP1, as well as activation of oncogenic transcription factor Stat3, are abrogated in p384-null setting...
  72. Regulatory Oxygenases in Vasculopathic Rickettsioses
    SANJEEV SAHNI; Fiscal Year: 2010
    ....
  73. Modulation of cancer prevention by social stress
    Hildegard M Schuller; Fiscal Year: 2010
    ....
  74. Theranostic Nanomedicine for Breast Cancer Prevention and Image-Guided Therapy
    Prakash R Rai; Fiscal Year: 2011
    ..Nanotechnology has made major contributions to BrCa therapy. We propose an innovative nanotechnology-based approach for BrCa prevention and treatment that could significantly impact patient care. ..
  75. Ellen Merrick Schill; Fiscal Year: 2015
    ..In addition, ENCCs from transgenic animals with null mutations in Cox1 and Cox2, enzymes inhibited by ibuprofen, will be analyzed by immunohistochemistry and time-lapse imaging to determine if ..
  76. Tpl2 in Carcinogenesis-Related Inflammation
    KATHLEEN LEIGH DECICCO-SKINNER; Fiscal Year: 2011
    ..This proposal investigates the role of one such gene, Tpl2, and how its absence contributes to skin cancer development ..
  77. Prakash R Rai; Fiscal Year: 2014
    ..This provides the potential for rapid screening to establish individualized patient-specific molecular targets and forms the basis for designing personalized prevention and treatments. ..
  78. Molecular Epidemiology of Chronic Liver Diseases
    Manal Hassan; Fiscal Year: 2009
    ..e., TGF-beta1, TNF-alpha, IL-lbeta, IL-10, IL-11, COX2) between cases and controls;and 2) to integrate the molecular and epidemiological data with the clinical features (..
  79. NFkB in the Astrocyte Swelling/Brain Edema with Acute Liver Failure
    MICHAEL DAVID NORENBERG; Fiscal Year: 2012
    ..We propose to examine the role of the transcription factor NF-:B as a critical intermediary responsible for causing brain swelling in ALF. ..
  80. Modeling oxidative stress and DNA damage using GI organotypic culture systems
    John P Lynch; Fiscal Year: 2013
    ..It will also foster the development of novel therapeutic and preventive strategies that will improve patient care for these important clinical conditions. ..
  81. ANDREW JESS DANNENBERG; Fiscal Year: 2015
    ..Collectively, the results of the proposed studies will offer new insights into strategies to reduce the risk of HR-positive breast cancer. ..
  82. SAM ANTONIO MESIANO; Fiscal Year: 2016
    ..with PR-A and PR-B affects basal and cytokine-induced expression of prostaglandin (PG) - endoperoxide synthase 2 (PTGS2;chosen as a prototypical pro-labor/pro-inflammatory gene) and I[unreadable]B[unreadable] in human myometrial cells ..
  83. Jenny T Mao; Fiscal Year: 2015
    ..Findings from the study will provide important insights into the feasibility and mechanistic effects of GSE against lung cancer, help identify SEBM and set the stage for future clinical trials. ..
  84. Arachidonic Acid Metabolism in Blood and Vascular Cells
    Jun Yang Liou; Fiscal Year: 2006
    ..Information provided by studies from this renewal application will have great impact on understanding the fundamental cytoprotection process and offer an excellent opportunity for developing new therapeutic agents. ..
  85. Molly F Kulesz-Martin; Fiscal Year: 2016
    ..tumor suppressor mechanisms (Trim32, Wnt, TGF[unreadable]1/SMAD, c-Myc, Ras and B-Raf, insulin-like growth factors, Cox2, Piasy, p73, inhibitory SMADs), and cytokines in cancer and inflammatory disorders, and fosters sharing of ..
  86. Francis M Giardiello; Fiscal Year: 2015
    ..abstract_text> ..
  87. Omega-3 Fatty Acid Effects on Pancreatitis and Adenocarcinoma Development
    Christopher A Jolly; Fiscal Year: 2013
    ..To test this hypothesis, we will use the cyclooxygenase 2 (COX-2) transgenic mouse model fed diets enriched in either the omega-3 fatty acid eicosapentaenoic acid (EPA)..
  88. Multimodality Imaging of GI Cancers for Diagnosis and Directed Therapy
    Christopher H Contag; Fiscal Year: 2013
    ..These aims are supported by two task specific projects and 5 cores with oversight by an executive committee. ..
  89. Cynthia Ju; Fiscal Year: 2016
    ..c) STAT3 activation and STAT1/NF-kB activation in BMMCs associated with mild ALD and ASH, respectively, will be investigated. ..
  90. Bombesin-Activated Carcinoma Associated Fibroblasts in Colorectal Cancer
    Celia Chao; Fiscal Year: 2013
    ..BN treatment of these CAFs stimulates their proliferation, activates NF(B, and induces cyclooxygenase (COX2) in an MEK/ERK pathway-dependent manner...
  91. Anand Venugopal; Fiscal Year: 2015
    ..We believe that these studies will be the first step in understanding the role for RBM3 in regulating intestinal stem cell physiology. ..
  92. Lenard M Lichtenberger; Fiscal Year: 2014
    ..These studies, therefore will establish the feasibility of using PL2200 for chemoprevention while lowering the risk of adverse GI events, resulting in the development of an efficacious and safe drug for prevention of colorectal cancer. ..
  93. TRANSLATIONAL CONTROL OF YEAST MITOCHONDRIAL GENES
    THOMAS DAVID FOX; Fiscal Year: 2013
    ..membrane translocases Oxa1 and Cox18, which have distinct functions in topogenesis of mitochondrially synthesized Cox2, promote Cox2 assembly after translocation of its hydrophilic domains to the IMS...
  94. Lir Wan Fan; Fiscal Year: 2016
    ....