PTEN

Summary

Gene Symbol: PTEN
Description: phosphatase and tensin homolog
Alias: 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, PTENbeta, TEP1, phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, MMAC1 phosphatase and tensin homolog deleted on chromosome 10, mitochondrial PTENalpha, mitochondrial phosphatase and tensin protein alpha, mutated in multiple advanced cancers 1, phosphatase and tensin-like protein, phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Species: human

Top Publications

  1. ncbi A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer
    Katrien Berns
    Division of Molecular Carcinogenesis and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Cancer Cell 12:395-402. 2007
  2. pmc The lipid phosphatase activity of PTEN is critical for its tumor supressor function
    M P Myers
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724 2208, USA
    Proc Natl Acad Sci U S A 95:13513-8. 1998
  3. ncbi Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
    P A Steck
    Department of Neuro Oncology, University of Texas, M D Anderson Cancer Center, Houston 77030, USA
    Nat Genet 15:356-62. 1997
  4. ncbi Pten is essential for embryonic development and tumour suppression
    A Di Cristofano
    Department of Human Genetics, Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute, New York, NY 10021, USA
    Nat Genet 19:348-55. 1998
  5. pmc Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner
    Min Sup Song
    Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Cell 144:187-99. 2011
  6. pmc MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer
    Fanyin Meng
    Department of Internal Medicine, Scott and White Clinic, Texas A and M University System Health Science Center College of Medicine, Temple, Texas, USA
    Gastroenterology 133:647-58. 2007
  7. pmc Subtle variations in Pten dose determine cancer susceptibility
    Andrea Alimonti
    Cancer Genetics Program, Department of Medicine, Beth Israel Deaconess Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Nat Genet 42:454-8. 2010
  8. pmc PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression
    Kim H T Paraiso
    Department of Molecular Oncology, The Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, Tampa, Florida, USA
    Cancer Res 71:2750-60. 2011
  9. pmc Phosphorylation of the PTEN tail regulates protein stability and function
    F Vazquez
    Department of Adult Oncology, Dana Farber Cancer Institute, and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 20:5010-8. 2000
  10. doi PTEN expression and KRAS mutations on primary tumors and metastases in the prediction of benefit from cetuximab plus irinotecan for patients with metastatic colorectal cancer
    Fotios Loupakis
    Department of Oncology, Azienda USL 6, Istituto Toscano Tumori, Livorno, Italy
    J Clin Oncol 27:2622-9. 2009

Research Grants

  1. Determinants of Efficacy to the Akt Inhibitor Perifosine in Colorectal Cancer
    Cathy Eng; Fiscal Year: 2012
  2. Novel TIRF microscopy analyzing trafficking & signaling at the cell cortex
    Derek Toomre; Fiscal Year: 2009
  3. Lloyd C Trotman; Fiscal Year: 2016
  4. Leszek Kotula; Fiscal Year: 2016
  5. Extranuclear estrogen receptor actions on endometrial cancer cell proliferation
    Twila A Jackson; Fiscal Year: 2012
  6. Signaling pathways regulated by GSK3 in hematopoietic stem cell
    Jian Huang; Fiscal Year: 2012
  7. Jian Huang; Fiscal Year: 2015
  8. Orin Bloch; Fiscal Year: 2016
  9. Connecting PTEN and NF2 cancer predisposition syndromes
    Maria Magdalena Georgescu; Fiscal Year: 2009
  10. JOHN HJ PETRINI; Fiscal Year: 2016

Detail Information

Publications355 found, 100 shown here

  1. ncbi A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer
    Katrien Berns
    Division of Molecular Carcinogenesis and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Cancer Cell 12:395-402. 2007
    ..RNA interference screen to discover genes involved in trastuzumab resistance in breast cancer identified only PTEN as a modulator of drug sensitivity...
  2. pmc The lipid phosphatase activity of PTEN is critical for its tumor supressor function
    M P Myers
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724 2208, USA
    Proc Natl Acad Sci U S A 95:13513-8. 1998
    ..Recently, a tumor suppressor from human chromosome 10q23, called PTEN or MMAC1, has been identified that shares homology with the protein tyrosine phosphatase family...
  3. ncbi Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
    P A Steck
    Department of Neuro Oncology, University of Texas, M D Anderson Cancer Center, Houston 77030, USA
    Nat Genet 15:356-62. 1997
    ..We have identified a gene, designated MMAC1, that spans these deletions and encodes a widely expressed 5.5-kb mRNA...
  4. ncbi Pten is essential for embryonic development and tumour suppression
    A Di Cristofano
    Department of Human Genetics, Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute, New York, NY 10021, USA
    Nat Genet 19:348-55. 1998
    The PTEN gene encodes a dual-specificity phosphatase mutated in a variety of human cancers...
  5. pmc Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner
    Min Sup Song
    Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Cell 144:187-99. 2011
    b>PTEN is a frequently mutated tumor suppressor gene that opposes the PI3K/AKT pathway through dephosphorylation of phosphoinositide-3,4,5-triphosphate...
  6. pmc MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer
    Fanyin Meng
    Department of Internal Medicine, Scott and White Clinic, Texas A and M University System Health Science Center College of Medicine, Temple, Texas, USA
    Gastroenterology 133:647-58. 2007
    ..Although a role for aberrant miRNA expression in cancer has been postulated, the pathophysiologic role and relevance of aberrantly expressed miRNA to tumor biology has not been established...
  7. pmc Subtle variations in Pten dose determine cancer susceptibility
    Andrea Alimonti
    Cancer Genetics Program, Department of Medicine, Beth Israel Deaconess Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Nat Genet 42:454-8. 2010
    ..However, this hypothesis has not yet been definitively supported in vivo. Pten is a TSG frequently lost in human cancer and mutated in inherited cancer-predisposition syndromes...
  8. pmc PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression
    Kim H T Paraiso
    Department of Molecular Oncology, The Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, Tampa, Florida, USA
    Cancer Res 71:2750-60. 2011
    This study addresses the role of PTEN loss in intrinsic resistance to the BRAF inhibitor PLX4720...
  9. pmc Phosphorylation of the PTEN tail regulates protein stability and function
    F Vazquez
    Department of Adult Oncology, Dana Farber Cancer Institute, and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 20:5010-8. 2000
    The PTEN gene is a tumor suppressor localized in the frequently altered chromosomal region 10q23...
  10. doi PTEN expression and KRAS mutations on primary tumors and metastases in the prediction of benefit from cetuximab plus irinotecan for patients with metastatic colorectal cancer
    Fotios Loupakis
    Department of Oncology, Azienda USL 6, Istituto Toscano Tumori, Livorno, Italy
    J Clin Oncol 27:2622-9. 2009
    b>PTEN, AKT, and KRAS are epidermal growth factor receptor (EGFR) downstream regulators. KRAS mutations confer resistance to cetuximab...
  11. doi The functions and regulation of the PTEN tumour suppressor
    Min Sup Song
    Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Harvard Medical School, Boston, Massachuchetts 02215, USA
    Nat Rev Mol Cell Biol 13:283-96. 2012
    The importance of the physiological function of phosphatase and tensin homologue (PTEN) is illustrated by its frequent disruption in cancer...
  12. ncbi Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN
    M Tamura
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892 4370, USA
    Science 280:1614-7. 1998
    The tumor suppressor PTEN is a phosphatase with sequence similarity to the cytoskeletal protein tensin. Here the cellular roles of PTEN were investigated...
  13. pmc Pten loss and RAS/MAPK activation cooperate to promote EMT and metastasis initiated from prostate cancer stem/progenitor cells
    David J Mulholland
    Department of Molecular and Medical Pharmacology and Institute for Molecular Medicine, University of California, Los Angeles, California, USA
    Cancer Res 72:1878-89. 2012
    b>PTEN loss or PI3K/AKT signaling pathway activation correlates with human prostate cancer progression and metastasis...
  14. pmc NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN
    Xinjiang Wang
    Cell Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 522, New York, NY 10021, USA
    Cell 128:129-39. 2007
    The tumor suppressor PTEN, a critical regulator for multiple cellular processes, is mutated or deleted frequently in various human cancers. Subtle reductions in PTEN expression levels have profound impacts on carcinogenesis...
  15. doi PI3K/Akt and Stat3 signaling regulated by PTEN control of the cancer stem cell population, proliferation and senescence in a glioblastoma cell line
    Seok Ho Moon
    Department of Biomedical Science, College of Life Science, CHA University, Seoul, Republic of Korea
    Int J Oncol 42:921-8. 2013
    ..A number of genes have been implicated in glioblastoma including mutation and deletion of PTEN. PTEN is a regulator of PI3K-mediated Akt signaling pathways and has been recognized as a therapeutic target in ..
  16. pmc Oncogenic role of the E3 ubiquitin ligase NEDD4-1, a PTEN negative regulator, in non-small-cell lung carcinomas
    Nicola Amodio
    Department of Experimental and Clinical Medicine, University Magna Graecia, Catanzaro, Italy
    Am J Pathol 177:2622-34. 2010
    Loss of the PTEN tumor suppressor gene occurs frequently in non-small-cell lung carcinoma (NSCLC), although neither genetic alterations nor epigenetic silencing are significant predictors of PTEN protein levels...
  17. pmc MiR-205 determines the radioresistance of human nasopharyngeal carcinoma by directly targeting PTEN
    Changju Qu
    Department of Pathophysiology, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, China
    Cell Cycle 11:785-96. 2012
    ..A target prediction algorithm suggests that miR‑205 regulates expression of PTEN, a tumor-suppressor...
  18. doi MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN
    Hua Yang
    Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    Cancer Res 68:425-33. 2008
    ..miR-214 induces cell survival and cisplatin resistance through targeting the 3'-untranslated region (UTR) of the PTEN, which leads to down-regulation of PTEN protein and activation of Akt pathway...
  19. ncbi Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation
    D J Marsh
    Department of Adult Oncology and Charles A Dana Human Cancer Genetics Unit, Dana Farber Cancer Institute, Boston, MA 02115 6084, USA Molecular Oncology Laboratory, Institut Bergo
    Hum Mol Genet 7:507-15. 1998
    The tumour suppressor gene PTEN , which maps to 10q23.3 and encodes a 403 amino acid dual specificity phosphatase (protein tyrosine phosphatase; PTPase), was shown recently to play a broad role in human malignancy...
  20. ncbi Regulation of cell migration by the C2 domain of the tumor suppressor PTEN
    Myrto Raftopoulou
    Medical Research Council Laboratory for Molecular Cell Biology and Cell Biology Unit, Cancer Research UK Oncogene and Signal Transduction Group, University College London, Gower Street, London WC1E 6BT, UK
    Science 303:1179-81. 2004
    b>PTEN is a tumor suppressor protein that dephosphorylates phosphatidylinositol 3,4,5 trisphosphate and antagonizes the phosphatidylinositol-3 kinase signaling pathway...
  21. pmc The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells
    Li Bing Song
    State Key Laboratory of Oncology in South China, Sun Yat sen University Cancer Center, Guangzhou, People s Republic of China
    J Clin Invest 119:3626-36. 2009
    ..immunoprecipitation assays revealed that Bmi-1 transcriptionally downregulated expression of the tumor suppressor PTEN in tumor cells through direct association with the PTEN locus...
  22. doi PTEN genomic deletion is associated with p-Akt and AR signalling in poorer outcome, hormone refractory prostate cancer
    Kanishka Sircar
    The University of Texas MD Anderson Cancer Center, Department of Pathology, Houston, TX, USA
    J Pathol 218:505-13. 2009
    b>PTEN haploinsufficiency is common in hormone-sensitive prostate cancer, though the incidence of genomic deletion and its downstream effects have not been elucidated in clinical samples of hormone refractory prostate cancer (HRPC)...
  23. pmc MicroRNA-21 orchestrates high glucose-induced signals to TOR complex 1, resulting in renal cell pathology in diabetes
    Nirmalya Dey
    Veterans Affairs Research, South Texas Veterans Health Care System, San Antonio, Texas, USA
    J Biol Chem 286:25586-603. 2011
    ..glucose-induced reduction of the tumor suppressor protein phosphatase and tensin homolog deleted in chromosome 10 (PTEN) contributes to renal cell hypertrophy and matrix expansion...
  24. doi MiR-26a enhances metastasis potential of lung cancer cells via AKT pathway by targeting PTEN
    Boning Liu
    Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenviroment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, China
    Biochim Biophys Acta 1822:1692-704. 2012
    ..Phosphatase and tensin homolog (PTEN) was a direct target of miR-26a...
  25. ncbi Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex
    F Vazquez
    Department of Adult Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 276:48627-30. 2001
    b>PTEN is a tumor suppressor protein that functions, in large part, by dephosphorylating the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate and by doing so antagonizing the action of phosphoinositide 3-kinase...
  26. ncbi Frequent inactivation of PTEN by promoter hypermethylation in microsatellite instability-high sporadic colorectal cancers
    Ajay Goel
    Department of Medicine and Comprehensive Cancer Center, University of California San Diego, La Jolla, California, USA
    Cancer Res 64:3014-21. 2004
    Loss of PTEN tumor suppressor function is observed in tumors of breast, prostate, thyroid, and endometrial origin...
  27. ncbi Determining risk of biochemical recurrence in prostate cancer by immunohistochemical detection of PTEN expression and Akt activation
    Roble Bedolla
    University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Clin Cancer Res 13:3860-7. 2007
    ..study, we investigate whether loss of expression of the tumor suppressor phosphatase and tensin homologue deleted on chromosome 10 (PTEN) and the phosphorylated form of the cell survival protein Akt (pAkt) predicts biochemical recurrence.
  28. doi Inhibition of activated fibroblast growth factor receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation
    Sara A Byron
    Cancer and Cell Biology Division, Translational Genomics Research Institute, Phoenix, Arizona 85004, USA
    Cancer Res 68:6902-7. 2008
    KRAS activation and PTEN inactivation are frequent events in endometrial tumorigenesis, occurring in 10% to 30% and 26% to 80% of endometrial cancers, respectively...
  29. pmc PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability
    Ana Silva
    Unidade de Biologia do Cancro, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal
    J Clin Invest 118:3762-74. 2008
    Mutations in the phosphatase and tensin homolog (PTEN) gene leading to PTEN protein deletion and subsequent activation of the PI3K/Akt signaling pathway are common in cancer...
  30. ncbi Loss of Pten, a tumor suppressor, causes the strong inhibition of autophagy without affecting LC3 lipidation
    Takashi Ueno
    The Department of Biochemistry, Juntendo University School of Medicine, Hongo, Tokyo, Japan
    Autophagy 4:692-700. 2008
    1)Pten (phosphatase and tensin homolog deleted on chromosome ten), a tumor suppressor, is a phosphatase with a variety of substrate specificities...
  31. doi PTEN signaling in autism spectrum disorders
    Jing Zhou
    Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9133, USA
    Curr Opin Neurobiol 22:873-9. 2012
    b>PTEN germline mutations are found in a small subset of children diagnosed with autism spectrum disorder (ASD) and accompanying macrocephaly...
  32. doi MicroRNA-21 (miR-21) expression promotes growth, metastasis, and chemo- or radioresistance in non-small cell lung cancer cells by targeting PTEN
    Zhi Li Liu
    Department of Oncology, The Second Affiliated Hospital of Nanjing Medical University, 121 Jiangjiayuan Road, Nanjing 210011, Jiangsu, People s Republic of China
    Mol Cell Biochem 372:35-45. 2013
    ..Meanwhile, miR-21 mimics could inhibit expression of PTEN mRNA and protein and the luciferase activity of a PTEN 3'-untranslated region (UTR)-based reporter construct in ..
  33. pmc Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function
    Antonella Papa
    Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Cell 157:595-610. 2014
    b>PTEN dysfunction plays a crucial role in the pathogenesis of hereditary and sporadic cancers. Here, we show that PTEN homodimerizes and, in this active conformation, exerts lipid phosphatase activity on PtdIns(3,4,5)P3...
  34. ncbi PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
    J Li
    Department of Pathology, College of Physicians and Surgeons, Columbia University, 630 West 168 Street, New York, NY 10032, USA
    Science 275:1943-7. 1997
    ..of homozygous deletions on human chromosome 10q23 has led to the isolation of a candidate tumor suppressor gene, PTEN, that appears to be mutated at considerable frequency in human cancers...
  35. ncbi Essential role for nuclear PTEN in maintaining chromosomal integrity
    Wen Hong Shen
    Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Cell 128:157-70. 2007
    A broad spectrum of mutations in PTEN, encoding a lipid phosphatase that inactivates the P13-K/AKT pathway, is found associated with primary tumors...
  36. pmc miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation
    Michela Garofalo
    Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
    Cancer Cell 16:498-509. 2009
    ..We show that miR-221&222, by targeting PTEN and TIMP3 tumor suppressors, induce TRAIL resistance and enhance cellular migration through the activation of the ..
  37. ncbi TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta
    D M Li
    Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Cancer Res 57:2124-9. 1997
    ..TEP1 protein is identical to the protein encoded by the candidate tumor suppressor gene PTEN/MMAC1. Our functional studies of the TEP1 protein suggest that its tumor suppressor function may associate with its ..
  38. ncbi PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model
    L P Weng
    Clinical Cancer Genetics Program, Comprehensive Cancer Center, Division of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    Hum Mol Genet 10:599-604. 2001
    The tumour suppressor gene PTEN/MMAC1/TEP1 encodes a dual-specificity phosphatase that recognizes phosphatidylinositol-3,4,5-triphosphate and protein substrates...
  39. pmc Epidermal growth factor receptor and PTEN modulate tissue factor expression in glioblastoma through JunD/activator protein-1 transcriptional activity
    Yuan Rong
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Cancer Res 69:2540-9. 2009
    ..Epidermal growth factor receptor (EGFR) amplification and PTEN loss are two common genetic alterations seen in GBM but not in lower-grade astrocytomas that could be responsible ..
  40. doi Human immunodeficiency virus type 1 induces lytic cycle replication of Kaposi's-sarcoma-associated herpesvirus: role of Ras/c-Raf/MEK1/2, PI3K/AKT, and NF-κB signaling pathways
    Xiaolei Zhu
    State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210029, People s Republic of China
    J Mol Biol 410:1035-51. 2011
    ....
  41. ncbi Germline mutations in PTEN are present in Bannayan-Zonana syndrome
    D J Marsh
    Nat Genet 16:333-4. 1997
  42. doi The nuclear affairs of PTEN
    Sarah M Planchon
    Genomic Medicine Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Cell Sci 121:249-53. 2008
    b>PTEN encodes a major tumor-suppressor protein that is a dual-specificity phosphatase. Inactivation of PTEN has been shown to be involved in heritable and sporadic cancers...
  43. doi PTEN: a new guardian of the genome
    Y Yin
    Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Oncogene 27:5443-53. 2008
    The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) tumor suppressor is a phosphatase that antagonizes the phosphoinositol-3-kinase/AKT signaling pathway and suppresses cell survival as well as cell proliferation...
  44. pmc WWP2 is an E3 ubiquitin ligase for PTEN
    Subbareddy Maddika
    Laboratory of Cell Death and Cell Survival, Centre for DNA Fingerprinting and Diagnostics CDFD, Nampally, Hyderabad 500001, India
    Nat Cell Biol 13:728-33. 2011
    b>PTEN, a lipid phosphatase, is one of the most frequently mutated tumour suppressors in human cancer...
  45. ncbi Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome
    D Liaw
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Nat Genet 16:64-7. 1997
    ..Another group has independently isolated the same gene, termed MMAC1, and also found somatic mutations throughout the gene in advanced sporadic cancers...
  46. pmc Pathologic caveolin-1 regulation of PTEN in idiopathic pulmonary fibrosis
    Hong Xia
    Department of Medicine, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Am J Pathol 176:2626-37. 2010
    ..Fibroblasts isolated from IPF patients display pathological activation of PI3K/Akt caused by low PTEN phosphatase activity...
  47. pmc Sprouty2, PTEN, and PP2A interact to regulate prostate cancer progression
    Rachana Patel
    The Beatson Institute for Cancer Research, Glasgow, United Kingdom
    J Clin Invest 123:1157-75. 2013
    ..of these pathways, including sprouty2 (SPRY2), protein phosphatase 2A (PP2A), and phosphatase and tensin homolog (PTEN), are commonly inactivated in prostate cancer...
  48. pmc PTENα, a PTEN isoform translated through alternative initiation, regulates mitochondrial function and energy metabolism
    Hui Liang
    Institute of Systems Biomedicine, Department of Pathology, School of Basic Medical Sciences, Center for Age Related Diseases, Peking University Health Science Center, Beijing 100191, P R China
    Cell Metab 19:836-48. 2014
    b>PTEN is one of the most frequently mutated genes in human cancer. It is known that PTEN has a wide range of biological functions beyond tumor suppression...
  49. pmc Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling
    Hasan Korkaya
    Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    PLoS Biol 7:e1000121. 2009
    ..The protein phosphatase and tensin homolog (PTEN) is inactivated in a wide range of human cancers, an alteration that is associated with a poor prognosis...
  50. doi Expression of miRNAs and PTEN in endometrial specimens ranging from histologically normal to hyperplasia and endometrial adenocarcinoma
    Heejeong Lee
    Department of Hospital Pathology, The Catholic University of Korea, Seoul, Korea
    Mod Pathol 25:1508-15. 2012
    ..We also investigated the association between those miRNAs and PTEN status...
  51. ncbi PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway
    M Tamura
    Craniofacial Developmental Biology and Regeneration Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892 4370, USA
    J Biol Chem 274:20693-703. 1999
    The tumor suppressor PTEN is a phosphatase with sequence homology to tensin...
  52. ncbi Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association
    J O Lee
    Cellular Biochemistry and Biophysics Program, Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cell 99:323-34. 1999
    The PTEN tumor suppressor is mutated in diverse human cancers and in hereditary cancer predisposition syndromes. PTEN is a phosphatase that can act on both polypeptide and phosphoinositide substrates in vitro...
  53. ncbi Functional evaluation of PTEN missense mutations using in vitro phosphoinositide phosphatase assay
    S Y Han
    Department of Clinical Oncology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Cancer Res 60:3147-51. 2000
    The tumor suppressor gene PTEN is frequently mutated in diverse human cancers and in autosomal dominant cancer predisposition disorders...
  54. ncbi Reversible inactivation of the tumor suppressor PTEN by H2O2
    Seung Rock Lee
    Laboratory of Cell Signaling, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 8015, USA
    J Biol Chem 277:20336-42. 2002
    The tumor suppressor PTEN regulates cell migration, growth, and survival by removing the 3'-phosphate of phosphoinositides...
  55. ncbi Association of the polymorphisms in the 5'-untranslated region of PTEN gene with type 2 diabetes in a Japanese population
    Hajime Ishihara
    Sainou Hospital, Toyama 930 0887, Japan
    FEBS Lett 554:450-4. 2003
    Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is known to act as a lipid phosphatase hydrolyzing phosphatidylinositol (PI)(3,4,5)P(3) to PI(4,5)P(2)...
  56. ncbi Comparative genomic and functional analyses reveal a novel cis-acting PTEN regulatory element as a highly conserved functional E-box motif deleted in Cowden syndrome
    Marcus G Pezzolesi
    Genomic Medicine Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NE 50, Cleveland, OH 44195, USA
    Hum Mol Genet 16:1058-71. 2007
    Germline mutations in PTEN, encoding a phosphatase on 10q23, cause Cowden syndrome (CS) and Bannayan-Riley-Ruvalcaba syndrome (BRRS)...
  57. ncbi PTEN inactivation in lung cancer cells and the effect of its recovery on treatment with epidermal growth factor receptor tyrosine kinase inhibitors
    Rintaro Noro
    Department of Pulmonary Medicine Infection and Oncology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Int J Oncol 31:1157-63. 2007
    To understand the mechanisms of PTEN inactivation, which is reported to be involved in tumor progression and drug resistance in lung cancer, we analyzed the expression levels of PTEN at mRNA and protein levels, along with the genetic and ..
  58. pmc Tat-induced FOXO3a is a key mediator of apoptosis in HIV-1-infected human CD4+ T lymphocytes
    Alicja Dabrowska
    Department of Medicine, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 181:8460-77. 2008
    ..Apoptosis in these cells is triggered by the alteration of the Egr1-PTEN-Akt (early growth response-1/phosphate and tensin homolog deleted on chromosome 10/Akt) and p53 pathways, which ..
  59. doi In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models
    Klaus P Hoeflich
    Translational Oncology, Genentech, Inc, South San Francisco, California 94080, USA
    Clin Cancer Res 15:4649-64. 2009
    ..We investigated the role of mitogen-activated protein kinase kinase (MEK) and phosphatidylinositol 3-kinase (PI3K) inhibitors as targeted therapies for basal-like breast cancer...
  60. pmc Relevance of PTEN loss in brain metastasis formation in breast cancer patients
    Harriet Wikman
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Martinistreet 52, 20246 Hamburg, Germany
    Breast Cancer Res 14:R49. 2012
    ..Therefore, our aim was to identify molecular markers associated with the development of brain metastases in breast cancer...
  61. doi Upregulation of miR-153 promotes cell proliferation via downregulation of the PTEN tumor suppressor gene in human prostate cancer
    Ziqing Wu
    Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, PR China
    Prostate 73:596-604. 2013
    ..The present study was aimed at clarifying the biological functions of miR-153, one of the upregulated microRNAs in prostate cancers, and the signaling transduction induced by miR-153...
  62. pmc HIV-1 Tat promotes Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6-induced angiogenesis and tumorigenesis by regulating PI3K/PTEN/AKT/GSK-3β signaling pathway
    Feng Zhou
    State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, People s Republic of China
    PLoS ONE 8:e53145. 2013
    ..Mechanistic studies indicated Tat activates PI3K and AKT, and inactivates PTEN and GSK-3β in vIL-6 expressing cells...
  63. doi Clinical significance of tumor suppressor PTEN in colorectal carcinoma
    C P Hsu
    Department of Medical Laboratory Science and Biotechnology, Yuanpei University, Taiwan
    Eur J Surg Oncol 37:140-7. 2011
    ..mutation, hypermethylation and subcellular location of the tumor suppressor phosphatase and tensin homologue (PTEN) are closely correlated with carcinogenesis, progression and prognosis of malignancy...
  64. ncbi Regulation of PTEN by Rho small GTPases
    Zhong Li
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Nat Cell Biol 7:399-404. 2005
    b>PTEN (phosphatase and tensin homologue) is a phosphatase that dephosphorylates both protein and phosphoinositide substrates...
  65. ncbi Epigenetic silencing of the PTEN gene in melanoma
    Alireza Mirmohammadsadegh
    Department of Dermatology, Heinrich Heine University, Moorenstrasse 5, D 40225 Dusseldorf, Germany
    Cancer Res 66:6546-52. 2006
    Phosphatase and tensin homologue deleted from chromosome 10 (PTEN) seems to be an important tumor suppressor gene in melanoma...
  66. pmc Is PTEN loss associated with clinical outcome measures in human prostate cancer?
    P McCall
    Section of Surgery, Division of Cancer Sciences and Molecular Pathology, University of Glasgow, Glasgow Royal Infirmary, Glasgow G31 3ER, UK
    Br J Cancer 99:1296-301. 2008
    Inactivating PTEN mutations are commonly found in prostate cancer, resulting in an increased activation of Akt...
  67. doi IGF-1 mediates PTEN suppression and enhances cell invasion and proliferation via activation of the IGF-1/PI3K/Akt signaling pathway in pancreatic cancer cells
    Jiachi Ma
    Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Surg Res 160:90-101. 2010
    ..IGF-1 also down-regulates the tumor suppressor chromosome 10 (PTEN)...
  68. pmc TSC2 deficiency increases PTEN via HIF1alpha
    Lenin Mahimainathan
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Biol Chem 284:27790-8. 2009
    Substantial evidence suggests roles of TSC2 and PTEN in the development of cancer predisposition syndromes. Loss of TSC2 results in benign tumors, neurological disorders, and angiomyolipomas...
  69. doi PTEN differentially regulates expressions of ICAM-1 and VCAM-1 through PI3K/Akt/GSK-3β/GATA-6 signaling pathways in TNF-α-activated human endothelial cells
    Konstantin Tsoyi
    Department of Pharmacology, Institute of Health Sciences, School of Medicine, and Biomedical Center BK21, Gyeongsang National University, 92 Chilam dong, Jinju 660 751, Republic of Korea
    Atherosclerosis 213:115-21. 2010
    Phosphotase and tensin homolog deleted on chromosome 10 (PTEN) is a potent negative regulator of PI3K/Akt pathway...
  70. pmc Alkylation of the tumor suppressor PTEN activates Akt and β-catenin signaling: a mechanism linking inflammation and oxidative stress with cancer
    Tracy M Covey
    Department of Medicinal Chemistry, University of Utah Health Sciences Center, Salt Lake City, Utah, United States of America
    PLoS ONE 5:e13545. 2010
    b>PTEN, a phosphoinositide-3-phosphatase, serves dual roles as a tumor suppressor and regulator of cellular anabolic/catabolic metabolism...
  71. pmc High glucose upregulation of early-onset Parkinson's disease protein DJ-1 integrates the PRAS40/TORC1 axis to mesangial cell hypertrophy
    Falguni Das
    Department of Medicine, University of Texas Health Science Center at San Antonio, TX, 78229 3900, USA
    Cell Signal 23:1311-9. 2011
    ..The tumor suppressor protein PTEN acts as a negative regulator of Akt activation...
  72. doi PIK3CA mutations, PTEN, and pHER2 expression and impact on outcome in HER2-positive early-stage breast cancer patients treated with adjuvant chemotherapy and trastuzumab
    J D Jensen
    Department of Oncology, Odense University Hospital, and Institute of Clinical Research, University of Southern Denmark, Odense, Denmark
    Ann Oncol 23:2034-42. 2012
    ..factor receptor-2 (HER2) phosphorylation status (pHER2-Tyr1221/1222) and if PIK3CA, phosphatase and tensin homolog (PTEN), or pHER2 has an impact on outcome in HER2-positive early-stage breast cancer patients treated with adjuvant ..
  73. pmc Loss of PTEN expression is associated with increased risk of recurrence after prostatectomy for clinically localized prostate cancer
    Alcides Chaux
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Mod Pathol 25:1543-9. 2012
    b>PTEN (phosphatase and tensin homolog on chromosome 10) is one of the most frequently lost tumor suppressor genes in human cancers and it has been described in more than two-thirds of patients with advanced/aggressive prostate cancer...
  74. pmc Advancing precision medicine for prostate cancer through genomics
    Sameek Roychowdhury
    University of Michigan Medical School, 1400 E Medical Center Dr, 5316 CCGC, Ann Arbor, MI 48109 5940, USA
    J Clin Oncol 31:1866-73. 2013
    ..Furthermore, we review predictive biomarker candidates involving ETS gene rearrangements, PTEN inactivation, and androgen receptor signaling...
  75. pmc Protean PTEN: form and function
    Kristin A Waite
    Human Cancer Genetics, Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, 420 West 12th Avenue, Columbus, OH 43210, USA
    Am J Hum Genet 70:829-44. 2002
    Germline mutations distributed across the PTEN tumor-suppressor gene have been found to result in a wide spectrum of phenotypic features...
  76. ncbi Expression of mTOR signaling pathway markers in prostate cancer progression
    Celeste L Kremer
    Arizona Cancer Center, University of Arizona, 1525 N Campbell Avenue, Tucson, AZ 85724, USA
    Prostate 66:1203-12. 2006
    ..A preliminary investigation of immuno-histochemical expression of mammalian target of rapamycin (mTOR) pathway markers was undertaken to identify patterns of expression in prostate tissue...
  77. doi PTEN mutations and relationship to EGFR, ERBB2, KRAS, and TP53 mutations in non-small cell lung cancers
    Guang Jin
    Department of Biochemistry and Molecular Biology, School of Medicine, Kyungpook National University, Dong In 2Ga 101, Daegu 700 422, Republic of Korea
    Lung Cancer 69:279-83. 2010
    Somatic mutations of phosphatase and tensin homolog deleted on chromosome ten (PTEN) in non-small cell lung cancers (NSCLCs) have been investigated in but a small number of cases...
  78. pmc PTEN positively regulates UVB-induced DNA damage repair
    Mei Ming
    Department of Medicine, University of Chicago, Chicago, IL, USA
    Cancer Res 71:5287-95. 2011
    ..However, the critical genetic targets of UVB radiation are undefined. Here we show that attenuating PTEN in epidermal keratinocytes is a predisposing factor for UVB-induced skin carcinogenesis in mice...
  79. pmc Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression
    Muhan Chen
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Cancer Cell 20:173-86. 2011
    ..We show that Phlpp1-loss causes neoplasia and, on partial Pten-loss, carcinoma in mouse prostate...
  80. pmc Loss of TGF-β signaling and PTEN promotes head and neck squamous cell carcinoma through cellular senescence evasion and cancer-related inflammation
    Y Bian
    Functional Genomics Section, Laboratory of Cell and Developmental Biology, Bethesda, MD, USA
    Oncogene 31:3322-32. 2012
    ..Conditional activation of the PI3K/Akt pathway due to Pten deletion in the mouse head and neck epithelia gives rise to hyperproliferation, but only a few lesions progress to ..
  81. doi SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane
    Jian Huang
    Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine SJTU SM, Shanghai 200025, China
    Nat Commun 3:911. 2012
    The membrane association of the tumour suppressor phosphatase and tensin homologue (PTEN) is required to oppose the phosphatidylinositol-3-kinase/AKT pathway by dephosphorylation of phosphatidylinositol-3,4,5-triphosphate (PIP3)...
  82. ncbi Frequent genetic and biochemical alterations of the PI 3-K/AKT/PTEN pathway in head and neck squamous cell carcinoma
    Juana Maria Garcia Pedrero
    Instituto Universitario de Oncologia del Principado de Asturias IUOPA, Universidad de Oviedo, 6a planta C Julián Clavería s n, 33006 Oviedo, Asturias, Spain
    Int J Cancer 114:242-8. 2005
    We investigated the status of the PI 3-kinase/AKT/PTEN signaling pathway in a series of 117 head and neck squamous cell carcinomas (HNSCC) in a search for molecular alterations in genes/proteins with potential prognostic value...
  83. pmc Loss of PTEN expression is associated with colorectal cancer liver metastasis and poor patient survival
    Hirozumi Sawai
    Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya 4678601, Japan
    BMC Gastroenterol 8:56. 2008
    The tumour suppressor phosphatase and tensin homolog (PTEN) is an important negative regulator of cell-survival signaling...
  84. pmc PTEN dosage is essential for neurofibroma development and malignant transformation
    Caroline Gregorian
    Department of Molecular and Medical Pharmacology, Institute for Molecular Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 106:19479-84. 2009
    ..In a series of genetically engineered murine models, we perturbed RAS/RAF/MAPK or/and PTEN/PI3K/AKT pathway, individually or simultaneously, via conditional activation of K-ras oncogene or deletion of Nf1 ..
  85. pmc Loss of PTEN binding adapter protein NHERF1 from plasma membrane in glioblastoma contributes to PTEN inactivation
    Jennifer R Molina
    Department of Neuro Oncology and Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Cancer Res 70:6697-703. 2010
    ..The tumor suppressor PTEN, a major inhibitor of the phosphatidylinositol-3-OH kinase (PI3K)/Akt pathway, is frequently deleted in GBM tumors...
  86. doi Loss of PTEN expression by blocking nuclear translocation of EGR1 in gefitinib-resistant lung cancer cells harboring epidermal growth factor receptor-activating mutations
    Chizuko Yamamoto
    Department of Pharmaceutical Oncology and Laboratory of Molecular Cancer Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Res 70:8715-25. 2010
    ..Gefitinib-resistant PC-9/GEFs cell lines showed a marked downregulation of PTEN expression and increased Akt phosphorylation...
  87. ncbi Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding
    N B Adey
    Myriad Genetics Inc, Salt Lake City, Utah 84108, USA
    Cancer Res 60:35-7. 2000
    Two-hybrid searches with the tumor suppressor MMAC1/PTEN isolated the proteins hDLG and hMAST205...
  88. pmc Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation
    Shunyou Wang
    Departments of Molecular and Medical Pharmacology and Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California Los Angeles, 650 Charles E Young Drive South, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 103:1480-5. 2006
    b>PTEN (phosphatase and tensin homolog deleted on chromosome 10) is a potent tumor suppressor gene frequently mutated in human prostate cancers...
  89. pmc Tumor suppressor PTEN acts through dynamic interaction with the plasma membrane
    Francisca Vazquez
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 103:3633-8. 2006
    The tumor suppressor function of PTEN is strongly linked to its ability to dephosphorylate phosphatidylinositol-3,4,5 trisphosphate and, thereby, control cell growth, survival, and migration...
  90. ncbi Regulation of PTEN activity by its carboxyl-terminal autoinhibitory domain
    Leticia Odriozola
    Department of Oncological Sciences, Mount Sinai School of Medicine, New York, New York, 10029, USA
    J Biol Chem 282:23306-15. 2007
    The regulation of PTEN intrinsic biochemical properties has not been fully elucidated. In this report, we investigated the role of the PTEN carboxyl-terminal tail domain in regulating its membrane targeting and catalytic functions...
  91. pmc p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation
    Hongwu Zheng
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 455:1129-33. 2008
    ..The primary GBM subtype presents acutely as a high-grade disease that typically harbours mutations in EGFR, PTEN and INK4A/ARF (also known as CDKN2A), and the secondary GBM subtype evolves from the slow progression of a low-..
  92. pmc Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth
    David J Mulholland
    Department of Molecular and Medical Pharmacology and Institute for Molecular Medicine, School of Medicine, University of California, Los Angeles, CA 90095 1735, USA
    Cancer Cell 19:792-804. 2011
    Alteration of the PTEN/PI3K pathway is associated with late-stage and castrate-resistant prostate cancer (CRPC). However, how PTEN loss is involved in CRPC development is not clear...
  93. ncbi Phosphorylation-regulated cleavage of the tumor suppressor PTEN by caspase-3: implications for the control of protein stability and PTEN-protein interactions
    Josema Torres
    Instituto de Investigaciones Citologicas, Amadeo de Saboya 4, Valencia 46010, Spain
    J Biol Chem 278:30652-60. 2003
    b>PTEN phosphatase is one of the most commonly targeted tumor suppressors in human cancers and a key regulator of cell growth and apoptosis...
  94. ncbi Allosteric activation of PTEN phosphatase by phosphatidylinositol 4,5-bisphosphate
    Robert B Campbell
    University of Massachusetts Medical School, Department of Biochemistry and Molecular Pharmacology, Worcester, Massachusetts 01605, USA
    J Biol Chem 278:33617-20. 2003
    Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a tumor suppressor that is lost in many human tumors and encodes a phosphatidylinositol phosphate phosphatase specific for the 3-position of the inositol ring...
  95. pmc Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity
    Lao H Saal
    Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 104:7564-9. 2007
    ..Taking advantage of the observation that loss of PTEN, the negative regulator of PI3K, results in robust activation of this pathway, we developed and validated a ..
  96. pmc Potential value of PTEN in predicting cetuximab response in colorectal cancer: an exploratory study
    Evangelia Razis
    1st Department of Medical Oncology, Hygeia Hospital, Athens, Greece
    BMC Cancer 8:234. 2008
    ..The aim of this study was to explore EGFR and the downstream effector phosphatase and tensin homologue deleted on chromosome 10 (PTEN) as potential predictors of response to cetuximab.
  97. pmc PTEN phosphorylation and nuclear export mediate free fatty acid-induced oxidative stress
    Yong Wu
    1 Department of Biochemistry, University of California, Riverside, California
    Antioxid Redox Signal 20:1382-95. 2014
    ..This study aimed at establishing whether phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and its subcellular location play a role in FFA-induced endothelial oxidative stress.
  98. pmc Down-regulation of PTEN expression due to loss of promoter activity in human hepatocellular carcinoma cell lines
    Dong Zhu Ma
    Minstry of Health Key Laboratory of Glycocojugate Research, Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, 138 Yixueyuan Road, Shanghai 200032, China
    World J Gastroenterol 11:4472-7. 2005
    To investigate the regulation of phosphatase and tensin homolog deleted on chromosome ten (PTEN) gene expression in human hepatocellular carcinoma (HCC) cell lines.
  99. ncbi The novel role of Yin Yang 1 in the regulation of epithelial to mesenchymal transition in cancer via the dysregulated NF-κB/Snail/YY1/RKIP/PTEN Circuitry
    Benjamin Bonavida
    Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California at Los Angeles, USA
    Crit Rev Oncog 16:211-26. 2011
    ..deregulated gene products in this circuit, such as the metastasis-suppressor phosphatase and tensin homologue (PTEN; repressed by Snail) and the putative-metastasis inducer Yin Yang (YY) 1 (target of NF-κB) also have been ..
  100. ncbi Patterns of PIK3CA alterations in familial colorectal and endometrial carcinoma
    Miina Ollikainen
    Department of Medical Genetics, University of Helsinki, Helsinki, Finland
    Int J Cancer 121:915-20. 2007
    ..We searched for alterations in the catalytic domain of PI3K (PIK3CA), PTEN and KRAS, all of which may contribute to PI3K/AKT pathway activation, in a total of 160-familial colorectal (CRC) ..
  101. doi R280T mutation of p53 gene promotes proliferation of human glioma cells through GSK-3β/PTEN pathway
    Chenli Lin
    Department of Pathology, School of Medicine, Jinan University, Guangzhou, China
    Neurosci Lett 529:60-5. 2012
    ..e. R280T was detected in SWO-38 cells. Knockdown of R280T mutant p53 by RNA interference inhibited the GSK-3β/PTEN associated cell proliferation, and PI3K/Akt but not Wnt/β-catenin signaling pathway was involved in this process...

Research Grants95

  1. Determinants of Efficacy to the Akt Inhibitor Perifosine in Colorectal Cancer
    Cathy Eng; Fiscal Year: 2012
    ..be abnormally or constitutively activated (overexpression and mutation), altered by PI3K (mutation), and/or loss of PTEN (mutation, loss of heterozygosity, or methylation)...
  2. Novel TIRF microscopy analyzing trafficking & signaling at the cell cortex
    Derek Toomre; Fiscal Year: 2009
    ..Consistent with the recovery act's goal, this funding will provide full-time summer employment for 4 undergraduate students and accelerate scientific achievement of the parent DP2 award...
  3. Lloyd C Trotman; Fiscal Year: 2016
    Project Summary / Abstract Mechanisms and Treatment of PTEN Mutant Prostate Tumorigenesis PTEN is a tumor suppressor that is among the most frequently lost or mutated genes of human cancer...
  4. Leszek Kotula; Fiscal Year: 2016
    ..generated in the lab indicate that Abi1 acts downstream from the most commonly mutated gene in prostate cancer, PTEN, and regulates tumor invasion...
  5. Extranuclear estrogen receptor actions on endometrial cancer cell proliferation
    Twila A Jackson; Fiscal Year: 2012
    ..The role of PTEN in negatively regulating extranuclear estrogen receptor actions and consequent endometrial cancer cell ..
  6. Signaling pathways regulated by GSK3 in hematopoietic stem cell
    Jian Huang; Fiscal Year: 2012
    ..Recently, the PTEN-PI3K-mTOR pathway has been demonstrated to play an essential role in HSC maintenance...
  7. Jian Huang; Fiscal Year: 2015
    ..Recently, the PTEN-PI3K-mTOR pathway has been demonstrated to play an essential role in HSC maintenance...
  8. Orin Bloch; Fiscal Year: 2016
    ..It is unique as an immunosuppressive protein because its expression is linked to a fundamental step in oncogenesis: PTEN loss and activation of PI 3-kinase (PI(3)K)...
  9. Connecting PTEN and NF2 cancer predisposition syndromes
    Maria Magdalena Georgescu; Fiscal Year: 2009
    ..b>PTEN and neurofibromatosis-2 (NF2) are tumor suppressors that are inactivated in both somatic cancers and in cancer ..
  10. JOHN HJ PETRINI; Fiscal Year: 2016
    ..Genetic interactions with these mice and mice mutants in p53, ATM and PTEN will be examined to test the hypothesis that chromosome instability in Rad50 mutants will increase the penetrance ..
  11. Identification and characterization of tumor suppressor genes in prostate cancer
    Jin Tang Dong; Fiscal Year: 2010
    ..This hypothesis has been validated by knockout mouse studies for PTEN from 10q23, p27 from 12p12, and NKX3-1 from 8p21...
  12. Luis F Parada; Fiscal Year: 2016
    ..mouse models based on conditional inactivation of human astrocytoma-relevant tumor suppressors p53, Nf1, and Pten, wherein through somatic loss of heterozygosity, mutant mice develop tumors that histologically and molecularly ..
  13. mTOR signaling and sporadic chordomas
    Sangyeul Han; Fiscal Year: 2010
    ..In addition to TSC genes, other tumor suppressor genes such as PTEN, NF1 and LKB1 critically regulate mTOR signaling through TSC proteins...
  14. Role of Fox03a in Regulating the IPF Fibroblast Phenotype
    RICHARD S NHO; Fiscal Year: 2010
    ..We have discovered that polymerized type I collagen suppresses normal fibroblast proliferation via high PTEN activity which inhibits the major PI3K/Akt signaling pathway...
  15. Identifying mechanisms of liver stem cell proliferation and differentiation
    CARL BARTH ROUNTREE; Fiscal Year: 2010
    ..1% diet), and 3) a tissue specific induced regulatory knockout (Pten liver KO). To test our hypothesis, we developed the following specific aims...
  16. Oncogenic role of PIK3CA hotspot mutations
    RAMON E PARSONS; Fiscal Year: 2013
    ..Genetic relationships with the downstream oncogene Akt1 and the candidate collaborating partners PTEN, HER2/Erbb2 and IGF1R will then be investigated...
  17. Prevention of PTEN deletion driven prostate cancer by selenium
    Junxuan Lu; Fiscal Year: 2012
    ..Se, inhibits/prevents PCa progression from PIN to adenocarcinoma through targeting Akt signaling pathway in a Pten-deficiency mouse model. Two specific aims are proposed...
  18. Richard C Wang; Fiscal Year: 2016
    ..will employ an established model of non-melanoma skin cancer formation in skin with an inducible deletion of PTEN. These studies will transform our current understanding of how autophagy is regulated and impact how autophagy is ..
  19. Role of U19/Eaf2 in androgen-dependent prostate homeostasis
    Zhou Wang; Fiscal Year: 2013
    ..2. Test the hypothesis that U19 and Pten. Two commonly inactivated/down-regulated genes in human prostate cancer, functionally cooperate in suppression of ..
  20. Cancer-Associated, Interdependent Regulation of mTOR, AKT, and IKK/NF-kappaB
    ALBERT SIDNEY BALDWIN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Akt is widely activated in a variety of cancers via (i) mutation in the PTEN tumor suppressor, (ii) activating mutations in PI3K, and (ii) through growth factor receptor upregulation/stimulation...
  21. CLIFFORD JAMES ROSEN; Fiscal Year: 2015
    ..Osteoblasts from Igfbp2-/- mice have increased PTEN (phosphatase and tensin homolog) transcripts which can be suppressed by addition of exogenous IGFBP-2, IGF-I or HBD...
  22. Sandeep Burma; Fiscal Year: 2015
    ..that populate the GBM genomic landscape, 5 key genetic alterations dominate: loss of Ink4a, Arf, p53, or PTEN and amplification of EGFR (especially, the constitutively active EGFRvIII)...
  23. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
    ..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
  24. Bingcheng Wang; Fiscal Year: 2016
    ..Approximately 70% of primary PCa exhibit a loss of at least one PTEN allele and loss of both alleles is associated with advanced disease. PTEN loss leads to activation of PI3K/Akt...
  25. RAMON E PARSONS; Fiscal Year: 2016
    b>PTEN is a tumor suppressor that is mutated in many forms of human cancer...
  26. Notch-1 and IGF-1 crosstalk: new therapeutic strategies for NSCLC
    Maurizio Bocchetta; Fiscal Year: 2013
    ..Notch-1 provides survival signals to ACL cells mediating an intricate network of signaling pathways that includes PTEN, STAT, IGF-1, IGF-1R, Akt and its downstream targets...
  27. PTEN Gene Therapy for Vein Graft Disease
    Christopher D Kontos; Fiscal Year: 2010
    ..Thus, there is a critical need for novel approaches to prevent vein graft failure. PTEN is a lipid phosphatase that antagonizes the effects of phosphoinositide (PI) 3-kinase, a central regulator of ..
  28. RAYMOND DANIEL BLIND; Fiscal Year: 2015
    ..transcription factors bind phosphoinositides (PIPs), phospholipids that are essential to PI-3 kinase signaling in PTEN-dependent cancers...
  29. Role of Txnip in adapting fuel metabolism to nutritional state
    SIMON HUI; Fiscal Year: 2013
    ..impaired mitochondrial oxidation, TKO mice showed increased insulin/Akt signaling due to decreased amount of active PTEN (reduced form) and were resistance to high fat diet-induced diabetes...
  30. Robert C Rickert; Fiscal Year: 2016
    ..Herein we investigate the pivotal roles of SHIP and PTEN inositol phosphatases in regulating the PI3K pathway and its noted impact on late B cell maturation...
  31. Targeting the ARF/CtBP Axis in Pancreatic Cancer
    Steven R Grossman; Fiscal Year: 2010
    ..Binding Protein (CtBP) and downregulate the phosphatidylinositol-3 (PI3)-kinase pathway via derepression of PTEN expression...
  32. Role of lipid rafts and phosphoinositides in E. histolytica virulence
    Lesly A Temesvari; Fiscal Year: 2010
    ..This will be achieved by examining the function of PI 3-kinase and PTEN phosphatase, enzymes with complimentary roles in Pi- based signaling...
  33. Valerie Marie Weaver; Fiscal Year: 2014
    ..stiffness enhance integrin and growth factor receptor (GFR) signaling and regulate levels of the tumor suppressor PTEN. Accordingly, we hypothesize that collagen cross-linking stiffens the tissue to promote breast transformation by ..
  34. Energy Restrction and Mammary Cancer
    Henry J Thompson; Fiscal Year: 2013
    ..Since DER has direct effects, based on our ongoing work, on at least 4 tumor suppressor genes (LKB1, TSC2, PTEN, and p53) that are misregulated during the development of cancer, it is likely that work such as ours will provide ..
  35. Role of PTEN in Vascular Lesion Formation
    MARY CM WEISER-EVANS; Fiscal Year: 2012
    ..Our previous work indicates SMC-specific PTEN inactivation, a negative regulator of PI3-kinase signaling, is an early trigger driving vascular lesion formation...
  36. Christopher A Klug; Fiscal Year: 2014
    ..In mice, constitutive activation of Akt through inducible deletion of the Akt regulatory phosphatase, PTEN, results in rapid hematopoietic stem cell (HSC) loss from bone marrow and development of a transplantable, lethal ..
  37. Targeting PTEN Null Tumors via Inhibition of the p110beta Isoform of PI3 Kinase
    Thomas M Roberts; Fiscal Year: 2010
    ..The tumor suppressor PTEN, a lipid phosphatase, dephosphorylates PIP3, thereby antagonizing the actions of PI3K and regulating the PI3K ..
  38. Zhaoyong Hu; Fiscal Year: 2016
    ..We hypothesize that CKD activates ROCK1 leading to both PTEN activation and mitochondria fission, ultimately resulting in muscle wasting...
  39. C Ronald Kahn; Fiscal Year: 2015
    ..in insulin resistance, including the stress kinases JNK and p38;the major PIP3 phosphatase in cells and tissues PTEN;and a novel link between PI 3-kinase, endoplasmic reticulum (ER) stress and the unfolded protein response...
  40. PTEN, Cell Cycle and Neurofibrillary Degeneration
    Francesca Fang Liao; Fiscal Year: 2012
    ..We now identify the tumor suppressor PTEN as an upstream factor governing the CCEs in post-mitotic neurons based on our finding that nuclear PTEN regulates ..
  41. THE ROLE OF TROP2 IN PROSTATE STEM CELL BIOLOGY AND TUMORIGENESIS
    LOREN SCOTT MICHEL; Fiscal Year: 2013
    ..is dramatically expanded in histologically normal prostatic tissue prior to the onset of tumorigenesis in the PTEN null mouse model, and the cancers that arise in these mice also express high levels of Trop2...
  42. The Regulatory Role of PTEN on CXCR4-mediated Metastasis in Prostate Cancer Cells
    MAHANDRANAUTH ANAND CHETRAM; Fiscal Year: 2011
    ..The Phosphate and Tensin homolog deleted on chromosome 10 (PTEN) is a tumor suppressor which protects cells from becoming cancerous by regulating cell division, repair DNA damage ..
  43. Understanding and Eliminating Oncogenic EGFR Signaling in Malignant Glioma
    Alain Charest; Fiscal Year: 2013
    ..observed in human tumors, that is overexpression of EGFR along with loss of function of the p16lnk4a/p19ARF and PTEN tumor suppressor genes...
  44. Combined use of green tea and quercetin in prostate cancer
    SUSANNE MARGARETE HENNING; Fiscal Year: 2012
    ..alone or water control;and B) by treating transgenic phosphatase and tensin homolog deleted on chromosome 10 (PTEN) knock out mice with GT alone, Q alone and GT+ Q together using the concentration shown to be most effective for ..
  45. Vascular targeted pan PI-3 kinase inhibitor prodrug, SF1126 for glioma therapy
    DONALD DURDEN; Fiscal Year: 2012
    ..of pan PI-3 kinase inhibitors in preclinical models for glioma therapeutics and to evaluate the mechanisms for PTEN's regulation of glioma progression including elements of angiogenesis and downstream pharmacodynamic targets ..
  46. Jean Zhao; Fiscal Year: 2016
    ..Surprisingly p110beta has been shown to be key for tumors featuring Pten loss, though mechanistic understanding of this data has been lacking...
  47. The Control of T Cell Development in Responses by PTEN
    Laurence A Turka; Fiscal Year: 2011
    ..g., TCR, CD28, and γc cytokine receptors) signal via PI-3 kinase (PI3K). The tumor suppressor gene Pten is a lipid phosphatase which directly catalyzes the reverse of the PI3K reaction...
  48. Martin McMahon; Fiscal Year: 2016
    ..In Aim 2 we will test the hypothesis that the loss of the Ink4a/Arf, Pten or Trp53 tumor suppressor genes can influence the response of KRasG12D- or BRafV600E-induced lung tumors to ..
  49. p85/p110 PI3 Kinase-Structure, function and Physiology
    Jonathan M Backer; Fiscal Year: 2013
    ..A specific role of p110 catalytic subunit in the proliferation and tumorigenesis of PTEN null prostate cancer cells has been identified, but the mechanisms that regulate p110 in these cells are not clear...
  50. Jian Zhong; Fiscal Year: 2016
    ..combine activation of B-RAF with activation of PI3-kinase signaling (using a knock-out of the PI3-kinase antagonist PTEN) to see whether this combination will further boost regenerative optic nerve axon growth in vivo (Aim 3)...
  51. Richard H Gomer; Fiscal Year: 2015
    ..The chalone signal transduction pathway involves the PTEN and CnrN phosphatases and the BzpN transcription factor, and blocks proliferation by preventing the transition from ..
  52. Pier Paolo Pandolfi; Fiscal Year: 2014
    ..the mechanisms by which loss of Lrf triggers tumorigenesis and the cooperative mechanisms of loss of Lrf and the Pten tumor suppressor in prostate cancer progression...
  53. Targeting BRAF and MEK in tumors with BRAF and RAS mutations.
    David B Solit; Fiscal Year: 2012
    ..BRAF mutations commonly co-exist with PTEN loss in melanoma...
  54. microRNA Control of Wound Healing
    Chandan K Sen; Fiscal Year: 2013
    ..Hypothesis 3.2: Wound-induced up-regulation of miR-21 results in silencing of the target gene PTEN. Hypothesis 3...
  55. FACTORS THAT MODIFY INSULIN ACTION
    Maria G Buse; Fiscal Year: 2012
    ..Recent data indicate that PTEN protein expression is increased and insulin stimulated PtdIns(3,4,5)P3 is diminished...
  56. BROOKE ELIZABETH CHRISTIAN; Fiscal Year: 2014
    ..Akt is activated by PI3K signaling, which is negatively regulated by the tumor suppressor PTEN. Another potential mechanism of Akt hyperactivation is its inability to be polyubiquitinated and degraded...
  57. DAVID EMERSON GREEN; Fiscal Year: 2016
    ..alterations in the antiproliferative mediator, phosphatase and tensin homolog deleted on chromosome 10 (PTEN), whose reduced expression may participate in PH pathogenesis...
  58. SMOOTH MUSCLE CELL PROLIFERATION IN HUMAN CORONARY ARTERY BYPASS GRAFTS
    Devendra K Agrawal; Fiscal Year: 2012
    ..Recently, we observed temporal inactivation of PTEN, a multifunctional lipid phosphatase, causing proliferation of SV SMCs, and that PTEN overexpression decreased IGF-..
  59. Endothelin and Angiotensin Receptor Signaling in Pulmonary Hypertension
    PETER RUDOLPH POLGAR; Fiscal Year: 2013
    ..Our working hypothesis is that signal cascades involving MAPKs, the Akt/PI3K/PTEN system, small G-protein RhoA and heterotrimeric G- proteins work in various combinations to produce ET-1 through ..
  60. Carola Anke Neumann; Fiscal Year: 2014
    ..Prdx1 show higher phosphorylation of Akt on Ser473 and more inactive (oxidized) forms of the tumor suppressor PTEN. PTEN is readily inactivated via oxidation of the low pKa cysteine in its catalytic site...
  61. Todd A Waldman; Fiscal Year: 2016
    ..b>PTEN is one of the most commonly inactivated tumor suppressor genes in human cancer...
  62. Derivation of Mature Oocytes from Human Primordial Follicles
    AARON JW HSUEH; Fiscal Year: 2010
    ..Studies using mutant mice indicated that oocyte-specific deletion of the PTEN (Tumor-suppressor phosphatase with TENsin homology) gene or the downstream transcriptional factor Foxo3 promoted ..
  63. 2012 CSHL PTEN Pathways and Targets Conference
    David J Stewart; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): This proposal seeks support for the meeting on "PTEN Pathways and Targets" to be held at Cold Spring Harbor Laboratory March, 2012...
  64. Jiwang Zhang; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Our goal is to define the roles of Pten phosphorylation remodeling in hematopoietic stem cell (HSC) regulation...
  65. Sphingolipid Signaling in Endothelial Responses to Injury
    TERESA SANCHEZ GARCIA-VAO; Fiscal Year: 2013
    ..kinase (PI3K) pathway and the coupling of S1P2R to the G12/13-Rho pathway, which activates the phosphatase PTEN. While S1P1R regulates vascular permeability, angiogenesis and the inflammatory response of the endothelium, the ..
  66. Miho Iijima; Fiscal Year: 2016
    ..We have demonstrated that the intracellular level and localization of PIP3 are regulated by a lipid phosphatase, PTEN. PTEN is located at the rear end of chemotaxing cells and restricts the production of PIP3 at the leading edge...
  67. David J Kwiatkowski; Fiscal Year: 2016
    ..TSC), due to mutations in TSC1 orTSC2;Cowden syndrome and Bannayan-Riley-Ruvalcaba syndrome, due to mutations in PTEN;and Peutz-Jeghers syndrome, due to mutations in LKB1...
  68. Protein-thiol mixed disulfide in cataractogenesis
    Marjorie F Lou; Fiscal Year: 2013
    ..activity assays of denucleation enzymes (DNase II[unreadable] and ubiquitin) and bFGF-specific phosphatases (PTEN and Shp2)...
  69. Cheng Kui Qu; Fiscal Year: 2016
    ..PTPMT1, an evolutionarily conserved PTEN-like phosphatidylinositol phosphate (PIP) phosphatase, is localized to the mitochondrial inner membrane where ion ..
  70. SANDRA ANN REMPEL; Fiscal Year: 2015
    ..that inhibition of HSP27 suppresses SPARC-induced changes in cell morphology, migration and invasion in vitro in PTEN- null glioma cells...
  71. Donita C Brady; Fiscal Year: 2015
    ..with the BRAF inhibitor, vemurafenib, in a GEMM of melanoma driven by constitutively active BrafV600E and loss of Pten. In addition, I will investigate Ctr1 genetic ablation and Cu chelation in BRAF-mutant thyroid and colon cancers ..
  72. M James You; Fiscal Year: 2015
    ..Inactivation of PTEN, INK4a and ARF tumor suppressor genes is among the most frequent genetic events in T-ALL...
  73. Yun Qiu; Fiscal Year: 2015
    ..2, Examine mechanisms by which AR3 activity is regulated;Aim 3, Examine the functional interaction between AR and AR3 under both normal and Pten-deficient background and its contribution to prostate cancer progression.
  74. IRIS NIRA SMITH; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Structural mutation analysis of PTEN and its possible genotype-phenotype correlations in Endometriosis and Cancer The phosphatase and tensin homolog deleted on chromosome ten (PTEN) gene encodes a ..
  75. Diego H Castrillon; Fiscal Year: 2014
    ..of endometrial cancer progression have been documented, such as inactivating mutations of the tumor suppressor gene PTEN. However, PTEN mutations and most other well- documented genetic lesions in endometrial cancers represent early ..
  76. The Effect of Diet and Nutrients on the Progression and Treatment of Prostate Can
    George Thomas; Fiscal Year: 2013
    ..mediated PI3K/ mTORCI signaling pathway, which is opposed by a large number of tumor suppressors including PTEN, TSC1/2, NF1, LKB1, 4E-BP1, PDCD4, and PML...
  77. Disparities in Breast Cancer: Development and Survival in Hispanic and NHW Women
    Martha L Slattery; Fiscal Year: 2013
    ..white women and will include enes to be studied include SOC1, SOC2, AKT, FRAP1(alias mTOR), P13K, STK11, AMP, PTEN, VEGF, &S6K1,S6K2, CRP, NFKB, IKB, IL10, IL8, IL6, TNFalpha using an Illumina platform...
  78. James K Rowlett; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Benzodiazepines (BZs) are prescribed widely as anxiolytics, hypnotics, muscle relaxants, and anticonvulsants...
  79. John J Krolewski; Fiscal Year: 2016
    ..The experimental plan utilizes rodent AWIA models and a prostate-specific PTEN-deficient mouse model resembling human prostate cancer, in conjunction with CHESS-MRI to image both normal and ..
  80. Maha Abdellatif; Fiscal Year: 2014
    ..preliminary results show that miR-21 not only regulates phosphatase and tensin homologue deleted on chromosome 10 (PTEN), but also directly targets Fas Ligand (FasL)...
  81. RICHARD EUGENE PETERSON; Fiscal Year: 2014
    ..Aim 4: In utero and lactational TCDD exposure accelerates prostate adenocarcinoma progression in Nkx3.1;Pten mice and TCDD treatment in adulthood does likewise...
  82. Brent N Rexer; Fiscal Year: 2014
    ..Further, the hypothesis that activation of the PI3K pathway by PIK3CA mutation or PTEN loss predicts for clinical resistance to HER2 inhibitors will be tested in tumor samples from a neoajuvant clinical ..
  83. Hui Kuan Lin; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): As loss of PTEN tumor suppressive function resulting in aberrant Akt activation is a prevalent event in human cancers and associated with cancer metastasis, it is important to identify the key ..
  84. Zheng Dong; Fiscal Year: 2016
    ..We have further suggested that miR-687 may target PTEN, a key regulator of cell viability, cell cycle, growth, and proliferation...
  85. Timothy C Hallstrom; Fiscal Year: 2016
    ..Aim 3 tests FoxO and Pten/PI3K/Akt pathway regulation of Rb/E2F apoptosis and tumorigenesis in vivo in the mouse retina...
  86. Characterization of prostatic stem cells and prostate cancer-initiating cells
    Li Xin; Fiscal Year: 2012
    ..We will induce Pten deletion in individual lineages by infecting prostate epithelial cells from the PTENIoxp/loxp transgenic mouse ..
  87. Targeted Therapies in Breast Cancer
    Ingrid A Mayer; Fiscal Year: 2013
    ..We hypothesize that BC with low PTEN levels or Akt hyperactivation will have a higher response to combined blockade of the EGFR and PI3K/Akt signaling, ..
  88. Robert C Bast; Fiscal Year: 2015
    ..against platinum-resistant disease;4) detection of response to the AKT inhibitor perifosine in ovarian cancers with PTEN mutations;5) discovery that as many as 30% of ovarian cancer patients have BRCA dysfunction;and 6) identification ..
  89. Rita Ghosh; Fiscal Year: 2014
    ..1;Pten compound mutant mice...
  90. PTEN TUMOR SUPPRESSOR AND CELL CYCLE REGULATION
    Hong Sun; Fiscal Year: 2003
    ..TEP1 is identical to the candidate tumor suppressor PTEN or MMAC1, which was isolated by positional cloning method...
  91. ANXIETY--GABA RECEPTOR AND OPIOID GENE TRANSFER
    MARLENE WILSON; Fiscal Year: 2000
    DESCRIPTION: (Adapted From The Applicant's Abstract) The benzodiaepines (BZs) are widely prescribed for the treatment of anxiety-related disorders, although these compounds also have anticonvulsant, hypnotic, and sedative actions...
  92. Efficacy of GABAA a5 receptor inverse agonists in learning impaired rats
    EARL MICHAEL GIBBS; Fiscal Year: 2010
    ..b>BZs are listed as a Core Medicine in the WHO Essential Drug List and those on the market, such as Valium and Xanax, are ..
  93. Non-sedating modulators of GABA-A receptors for anxiety
    KELVIN GEE; Fiscal Year: 2009
    ..Few viable alternatives other than benzodiazepines (BZs), like diazepam, are used for the treatment of GAD...
  94. BENZODIAZEPINE TRIPLICATE PRESCRIPTION POLICY OUTCOMES
    Stephen Soumerai; Fiscal Year: 1999
    DESCRIPTION: (Applicant's Abstract) Benzodiazepines (BZs) are important, effective drugs when used appropriately for anxiety, sleep and seizure disorders...