PRX

Summary

Gene Symbol: PRX
Description: periaxin
Alias: CMT4F, periaxin
Species: human

Top Publications

  1. ncbi A comparison of dopamine agonists and catechol-O-methyltransferase inhibitors in Parkinson's disease
    R Inzelberg
    Department of Neurology, Hillel Yaffe Medical Center, Hadera, Israel
    Clin Neuropharmacol 23:262-6. 2000
  2. ncbi Protective agents in acute high-dose organophosphate exposure: comparison of ranitidine with pralidoxime in rats
    G A Petroianu
    Department of Pharmacology, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
    J Appl Toxicol 25:68-73. 2005
  3. ncbi Five oximes (K-27, K-33, K-48, BI-6 and methoxime) in comparison with pralidoxime: in vitro reactivation of red blood cell acetylcholinesterase inhibited by paraoxon
    G A Petroianu
    UAE University, Al Ain UAE
    J Appl Toxicol 26:64-71. 2006
  4. ncbi Effect of pyridostigmine, pralidoxime and their combination on survival and cholinesterase activity in rats exposed to the organophosphate paraoxon
    Georg A Petroianu
    Faculty of Medicine and Health Sciences, Department of Pharmacology and Therapeutics, United Arab Emirates University, P O Box 17 666, Al Ain, United Arab Emirates
    Arch Toxicol 80:777-84. 2006
  5. ncbi In vitro oxime reactivation of red blood cell acetylcholinesterase inhibited by methyl-paraoxon
    G A Petroianu
    UAE University, Al Ain UAE
    J Appl Toxicol 27:168-75. 2007
  6. pmc Mapping of a new locus for autosomal recessive demyelinating Charcot-Marie-Tooth disease to 19q13.1-13.3 in a large consanguineous Lebanese family: exclusion of MAG as a candidate gene
    V Delague
    Unite de Genetique Medicale, Faculte de Medecine, Université Saint Joseph, Paris, France
    Am J Hum Genet 67:236-43. 2000
  7. ncbi A tripartite nuclear localization signal in the PDZ-domain protein L-periaxin
    D L Sherman
    Department of Preclinical Veterinary Sciences, University of Edinburgh, Edinburgh EH9 1QH, United Kingdom
    J Biol Chem 275:4537-40. 2000
  8. pmc Periaxin mutations cause recessive Dejerine-Sottas neuropathy
    C F Boerkoel
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Hum Genet 68:325-33. 2001
  9. ncbi A mutation in periaxin is responsible for CMT4F, an autosomal recessive form of Charcot-Marie-Tooth disease
    A Guilbot
    INSERM U289, Hopital de la Salpetriere, 47 Boulevard de l Hopital, Paris, France
    Hum Mol Genet 10:415-21. 2001
  10. ncbi Specific disruption of a schwann cell dystrophin-related protein complex in a demyelinating neuropathy
    D L Sherman
    Department of Preclinical Veterinary Sciences, University of Edinburgh, EH9 1QH, Edinburgh, United Kingdom
    Neuron 30:677-87. 2001

Research Grants

  1. Mechanistic Studies of Alkyl Hydroperoxide Reductase and Related Redox Proteins
    Leslie B Poole; Fiscal Year: 2013
  2. W Todd Lowther; Fiscal Year: 2014
  3. Mark S Nanes; Fiscal Year: 2014
  4. Aron B Fisher; Fiscal Year: 2016
  5. Prx1 in malignant progression of prostate cancer
    Candace S Johnson; Fiscal Year: 2010
  6. Redox control of CD8 T cell proliferation, differentiation and death
    JASON MITCHELL GRAYSON; Fiscal Year: 2012
  7. Fiber Cell Cytoskeletal Scaffolds-Role in Lens Architecture and Function
    P Vasantha Rao; Fiscal Year: 2011
  8. Cyclooxygenases in Skeletal Repair
    Xinping Zhang; Fiscal Year: 2013
  9. NEW HOMEBOX GENES IN SCARLESS FETAL WOUND HEALING
    Corey Largman; Fiscal Year: 2001
  10. HTS Inhibitors:Schistosoma Mansoni Peroxiredoxins(RMI)
    David Williams; Fiscal Year: 2005

Detail Information

Publications195 found, 100 shown here

  1. ncbi A comparison of dopamine agonists and catechol-O-methyltransferase inhibitors in Parkinson's disease
    R Inzelberg
    Department of Neurology, Hillel Yaffe Medical Center, Hadera, Israel
    Clin Neuropharmacol 23:262-6. 2000
    To compare the efficacy and tolerability of three dopamine agonists--pergolide (PRG), pramipexole (PRX), and ropinirole (ROP)-and two catechol-O-methyltranferase (COMT) inhibitors-tolcapone (TOL) and entacapone (ENT)-as add-on therapies ..
  2. ncbi Protective agents in acute high-dose organophosphate exposure: comparison of ranitidine with pralidoxime in rats
    G A Petroianu
    Department of Pharmacology, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
    J Appl Toxicol 25:68-73. 2005
    ..paraoxon, POX) exposure in rats in direct comparison with the therapeutic gold-standard pralidoxime (PRX)...
  3. ncbi Five oximes (K-27, K-33, K-48, BI-6 and methoxime) in comparison with pralidoxime: in vitro reactivation of red blood cell acetylcholinesterase inhibited by paraoxon
    G A Petroianu
    UAE University, Al Ain UAE
    J Appl Toxicol 26:64-71. 2006
    Oximes are cholinesterase reactivators of use in poisoning with organophosphorus compounds. Pralidoxime (PRX) is used clinically as an adjunct to atropine in such exposure...
  4. ncbi Effect of pyridostigmine, pralidoxime and their combination on survival and cholinesterase activity in rats exposed to the organophosphate paraoxon
    Georg A Petroianu
    Faculty of Medicine and Health Sciences, Department of Pharmacology and Therapeutics, United Arab Emirates University, P O Box 17 666, Al Ain, United Arab Emirates
    Arch Toxicol 80:777-84. 2006
    ..POX is a highly toxic non-neuropathic ethyl organophospate. Pralidoxime (PRX) is the enzyme reactivator used by some NATO armies...
  5. ncbi In vitro oxime reactivation of red blood cell acetylcholinesterase inhibited by methyl-paraoxon
    G A Petroianu
    UAE University, Al Ain UAE
    J Appl Toxicol 27:168-75. 2007
    ..Pralidoxime (PRX) is the oxime used in the United States...
  6. pmc Mapping of a new locus for autosomal recessive demyelinating Charcot-Marie-Tooth disease to 19q13.1-13.3 in a large consanguineous Lebanese family: exclusion of MAG as a candidate gene
    V Delague
    Unite de Genetique Medicale, Faculte de Medecine, Université Saint Joseph, Paris, France
    Am J Hum Genet 67:236-43. 2000
    ..affecting this family constitutes a previously unknown demyelinating autosomal recessive CMT subtype known as "CMT4F." The myelin-associated glycoprotein (MAG) gene, located on 19q13...
  7. ncbi A tripartite nuclear localization signal in the PDZ-domain protein L-periaxin
    D L Sherman
    Department of Preclinical Veterinary Sciences, University of Edinburgh, Edinburgh EH9 1QH, United Kingdom
    J Biol Chem 275:4537-40. 2000
    The murine Periaxin gene encodes two PDZ-domain proteins in myelin-forming Schwann cells of the vertebrate peripheral nervous system (Dytrych, L., Sherman, D. L., Gillespie, C. S., and Brophy, P. J. (1998) J. Biol. Chem. 273, 5794-5800)...
  8. pmc Periaxin mutations cause recessive Dejerine-Sottas neuropathy
    C F Boerkoel
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Hum Genet 68:325-33. 2001
    The periaxin gene (PRX) encodes two PDZ-domain proteins, L- and S-periaxin, that are required for maintenance of peripheral nerve myelin...
  9. ncbi A mutation in periaxin is responsible for CMT4F, an autosomal recessive form of Charcot-Marie-Tooth disease
    A Guilbot
    INSERM U289, Hopital de la Salpetriere, 47 Boulevard de l Hopital, Paris, France
    Hum Mol Genet 10:415-21. 2001
    ..L- and S-periaxin are proteins of myelinating Schwann cells and homozygous periaxin-null mice display extensive demyelination of ..
  10. ncbi Specific disruption of a schwann cell dystrophin-related protein complex in a demyelinating neuropathy
    D L Sherman
    Department of Preclinical Veterinary Sciences, University of Edinburgh, EH9 1QH, Edinburgh, United Kingdom
    Neuron 30:677-87. 2001
    ..The complex is clustered by the interaction of DRP2 with L-periaxin, a homodimeric PDZ domain-containing protein...
  11. ncbi A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells
    Beate K Straub
    Division of Cell Biology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Cell Sci 116:4985-95. 2003
    ..The other complex contains ezrin, periplakin, periaxin and desmoyokin (and so is called the EPPD complex), usually together with moesin, spectrin(s) and plectin...
  12. ncbi Periaxin mutation causes early-onset but slow-progressive Charcot-Marie-Tooth disease
    Kazuki Kijima
    Department of Pediatrics, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    J Hum Genet 49:376-9. 2004
    b>Periaxin (PRX) plays a significant role in the myelination of the peripheral nerve...
  13. ncbi Five oximes (K-27, K-33, K-48, BI-6 and methoxime) in comparison with pralidoxime: survival in rats exposed to the organophosphate paraoxon
    G A Petroianu
    UAE University, Al Ain UAE
    J Appl Toxicol 26:262-8. 2006
    Oximes are cholinesterase reactivators used in organophosphorus poisoning. Clinical experience with pralidoxime (PRX) and other oximes is disappointing and their routine use has been questioned...
  14. ncbi Pralidoxime and l-lactate effects in vitro on the inhibition of acetylcholinesterase by paraoxon: pralidoxime does not confer superior protection
    G Petroianu
    University of Heidelberg at Mannheim, Department of Pharmacology and Toxicology, Maybach Street 14 16, 68169 Mannheim, Germany
    J Appl Toxicol 21:7-13. 2001
    ..To assess the practical relevance, if any, of these findings, the protective effects of pralidoxime (PRX) and those of lactate had to be compared in the same in vitro model...
  15. ncbi Characterization of a mammalian peroxiredoxin that contains one conserved cysteine
    S W Kang
    Laboratory of Cell Signaling, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 273:6303-11. 1998
    ..TPx homologs, termed peroxiredoxin (Prx), have also been identified and include several proteins, designated 1-Cys Prx, that contain only one conserved ..
  16. ncbi Hyperoxidized peroxiredoxins and glyceraldehyde-3-phosphate dehydrogenase immunoreactivity and protein levels are changed in the gerbil hippocampal CA1 region after transient forebrain ischemia
    In Koo Hwang
    Department of Anatomy and Neurobiology, College of Medicine, Hallym University, Chuncheon 200 702, South Korea
    Neurochem Res 32:1530-8. 2007
    ..present study, we investigated transient ischemia-induced chronological changes in hyperoxidized peroxiredoxins (Prx-SO3) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH-SO3) immunoreactivity and protein levels in the gerbil ..
  17. pmc Decreased expression of peroxiredoxins in Fuchs' endothelial dystrophy
    Ula V Jurkunas
    Schepens Eye Research Institute, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 49:2956-63. 2008
    To compare the relative expression of peroxiredoxin (Prx) proteins in normal human corneal endothelium with endothelium in corneas affected by Fuchs' endothelial dystrophy (FED) and between normal human endothelium and epithelial/stromal ..
  18. pmc The peroxiredoxin and glutathione peroxidase families in Chlamydomonas reinhardtii
    Régine Dayer
    Department of Environmental Toxicology, Eawag, Swiss Federal Institute of Aquatic Science and Technology, Ueberlandstrasse 133, CH 8600, Duebendorf, Switzerland
    Genetics 179:41-57. 2008
    ..PRXs are present in diverse subcellular compartments and divided into four types: 2-cys PRX, 1-cys PRX, PRX-Q, and type II PRX (PRXII)...
  19. ncbi Characterization of clutathione amide reductase from Chromatium gracile. Identification of a novel thiol peroxidase (Prx/Grx) fueled by glutathione amide redox cycling
    B Vergauwen
    Laboratory of Protein Biochemistry and Protein Engineering, Gent University, 9000 Gent, Belgium
    J Biol Chem 276:20890-7. 2001
    ..We suggest GAR to be the newest member of the class I flavoprotein disulfide reductase family of oxidoreductases...
  20. ncbi The thiol-based redox networks of pathogens: unexploited targets in the search for new drugs
    Timo Jaeger
    MOLISA GmbH, Molecular Links Sachsen Anhalt, Universitatsplatz 2, D 39106 Magdeburg, Germany
    Biofactors 27:109-20. 2006
    ..linked via glutaredoxin and plasmoredoxin to terminal thioredoxin peroxidases belonging to both, the peroxiredoxin (Prx) and glutathione peroxidase (GPx) family...
  21. doi Supramolecular control of polyplex dissociation and cell transfection: efficacy of amino groups and threading cyclodextrins in biocleavable polyrotaxanes
    Atsushi Yamashita
    School of Materials Science, Japan Advanced Institute of Science and Technology, 1 1 Asahidai, Nomi, Ishikawa 923 1292, Japan
    J Control Release 131:137-44. 2008
    ..onto a poly(ethylene glycol) (PEG) chain capped with benzyloxycarbonyl-L-tyrosine via disulfide linkages (DMAE-SS-PRX), involves the formation of a stable polyion complex (polyplex) against a counter polyanion and the intracellular ..
  22. pmc Biomphalaria glabrata peroxiredoxin: effect of schistosoma mansoni infection on differential gene regulation
    Matty Knight
    Biomedical Research Institute, 12111 Parklawn Drive, Rockville, MD 20852, USA
    Mol Biochem Parasitol 167:20-31. 2009
    ..screened and a partial cDNA encoding an antioxidant enzyme thioredoxin peroxidase (Tpx), or peroxiredoxin (Prx), was identified...
  23. ncbi A chicken homeobox gene related to Drosophila paired is predominantly expressed in the developing limb
    T Nohno
    Department of Pharmacology, Kawasaki Medical School, Kurashiki City, Japan
    Dev Biol 158:254-64. 1993
    We identified a homeobox-containing gene, Prx-1, isolated from the chick limb bud cDNA library. The homeodomain sequence is related to Drosophila paired and goose-berry and mouse Pax-3, Pax-6, and Pax-7...
  24. pmc Divergent light-, ascorbate-, and oxidative stress-dependent regulation of expression of the peroxiredoxin gene family in Arabidopsis
    Frank Horling
    Department of Plant Physiology and Biochemistry W5, University of Bielefeld, 33501 Bielefeld, Germany
    Plant Physiol 131:317-25. 2003
    Peroxiredoxins (prxs) are peroxidases with broad substrate specificity. The seven prx genes expressed in Arabidopsis shoots were analyzed for their expressional response to changing photon fluence rates, oxidative stress, and ascorbate ..
  25. ncbi Paired-related homeobox genes cooperate in handplate and hindlimb zeugopod morphogenesis
    M F Lu
    Center for Cancer Biology and Nutrition, Texas A and M University, Houston, Texas, 77030 3303, USA
    Dev Biol 205:145-57. 1999
    The closely related homeobox genes prx-1 and prx-2 are expressed in lateral plate and limb bud mesoderm, but targeted inactivation of these genes failed to demonstrate a limb phenotype...
  26. ncbi Synergistic action of piroxicam on the eicosapentaenoic acid-induced apoptosis is associated with enhanced down-regulation of anti-apoptotic Bcl-2 expression but not promoted activation of pro-apoptotic Bid protein
    Lawrence C M Chiu
    Department of Biology, The Chinese University of Hong Kong, Hong Kong SAR, P R China
    Oncol Rep 11:225-30. 2004
    ..In this study, effect of piroxicam (PRX), a COX inhibitor, on the EPA-induced apoptosis in HL-60 cells was investigated...
  27. pmc Ol-Prx 3, a member of an additional class of homeobox genes, is unimodally expressed in several domains of the developing and adult central nervous system of the medaka (Oryzias latipes)
    J S Joly
    Laboratoire de Genetique des Poissons, Domaine de Vilvert, Institut National de la Recherche Agronomique, Jouy en Josas, France
    Proc Natl Acad Sci U S A 94:12987-92. 1997
    ..In this context, we report the characterization of Ol-Prx 3 (Oryzias latipes-Prx 3)...
  28. ncbi Cerebrovascular reactivity during hypothermia and rewarming
    A Lavinio
    Department of Clinical Neurosciences, Academic Neurosurgical Unit, Addenbrooke s Hospital, Cambridge, UK
    Br J Anaesth 99:237-44. 2007
    ..The effects of hypothermia and subsequent rewarming on cerebral vasoreactivity in human TBI are unknown...
  29. doi Continuous monitoring of cerebrovascular pressure reactivity in patients with head injury
    Christian Zweifel
    Academic Neurosurgical Unit, University of Cambridge Clinical School, Cambridge, United Kingdom
    Neurosurg Focus 25:E2. 2008
    ..A cerebrovascular pressure reactivity index (PRx) can be determined as the moving correlation coefficient between mean intracranial pressure (ICP) and mean arterial ..
  30. pmc The effects of acrolein on peroxiredoxins, thioredoxins, and thioredoxin reductase in human bronchial epithelial cells
    Charles R Myers
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Toxicology 257:95-104. 2009
    ..Trx1) and mitochondrial (Trx2) thioredoxins in the reduced state, and the thioredoxins keep the peroxiredoxins (Prx) reduced, thereby supporting their peroxidase function...
  31. ncbi Fluorescence quenching of Acridine Orange in microemulsions induced by the non-steroidal anti-inflammatory drug Piroxicam
    Suzana M Andrade
    Centro de Quimica Estrutural, Complexo 1, Instituto Superior Tecnico, 1049 001 Lisboa, Portugal
    Photochem Photobiol Sci 2:605-10. 2003
    ..quenching of Acridine Orange (AO) by methyl viologen (MV2+) and the non-steroidal anti-inflammatory drug Piroxicam (Prx), incorporated in sodium bis(2-ethylhexyl) sulfosuccinate (AOT)/isooctane/water and Triton X-100 (Trx-100)/..
  32. doi PRX-08066, a novel 5-hydroxytryptamine receptor 2B antagonist, reduces monocrotaline-induced pulmonary arterial hypertension and right ventricular hypertrophy in rats
    Stacy L Porvasnik
    Department of Pediatrics, Powell Gene Therapy Center, University of Florida, Gainesville, Florida 32610 0266, USA
    J Pharmacol Exp Ther 334:364-72. 2010
    ..5-((4-(6-Chlorothieno[2,3-d]pyrimidin-4-ylamino)piperidin-1-yl)methyl)-2-fluorobenzonitrile monofumarate (PRX-08066) is a selective 5-hydroxytryptamine receptor 2B (5-HT2BR) antagonist that causes selective vasodilation of ..
  33. ncbi Removal of hydrogen peroxide by a 1-cysteine peroxiredoxin enzyme of the filarial parasite Dirofilaria immitis
    R Chandrashekar
    Heska Corporation, Fort Collins, CO 80525, USA
    Parasitol Res 86:200-6. 2000
    ..of studies carried out on the biochemical activity and on immunolocalization of a recombinant peroxiredoxin (Prx) enzyme from the dog filarial parasite Dirofilaria immitis...
  34. ncbi Modeling human peroxisome biogenesis disorders in the nematode Caenorhabditis elegans
    Heather Thieringer
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08554, USA
    J Cell Sci 116:1797-804. 2003
    ..green fluorescent protein reporter targeted to the peroxisome, we establish that peroxisomal import is impaired in prx-5(RNAi) nematodes...
  35. ncbi Crystal structure of an archaeal peroxiredoxin from the aerobic hyperthermophilic crenarchaeon Aeropyrum pernix K1
    Eiichi Mizohata
    RIKEN Genomic Sciences Center, 1 7 22 Suehiro cho, Tsurumi, Yokohama 230 0045, Japan
    J Mol Biol 354:317-29. 2005
    ..We present here the X-ray crystal structure of an archaeal Prx from the aerobic hyperthermophilic crenarchaeon, Aeropyrum pernix K1, determined at 2.3 A resolution (Rwork of 17...
  36. ncbi The function of peroxiredoxins in plant organelle redox metabolism
    Karl Josef Dietz
    Biochemistry and Physiology of Plants, W5 134, Bielefeld University, D 33501 Bielefeld, Germany
    J Exp Bot 57:1697-709. 2006
    In 1996, cDNA sequences referred to as plant peroxiredoxins (Prx), i.e. a 1-Cys Prx and a 2-Cys Prx, were reported from barley...
  37. ncbi Four thiol peroxidases contain a conserved GCT catalytic motif and act as a versatile array of lipid peroxidases in Anabaena sp. PCC7120
    Mee Kyung Cha
    Department of Biochemistry, Paichai University, 439 6 Doma 2 Dong Seo Gu, Taejon 302 735, Republic of Korea
    Free Radic Biol Med 42:1736-48. 2007
    ..genome contains seven open reading frames with homology to thiol peroxidase (TPx), also known as peroxiredoxin (Prx)...
  38. ncbi Association between intracranial, arterial pulse pressure amplitudes and cerebral autoregulation in head injury patients
    P K Eide
    Department of Neurosurgery, The National Hospital Rikshospitalet, Oslo, Norway
    Neurol Res 29:578-82. 2007
    ....
  39. doi Insights into the catalytic mechanism of the Bcp family: functional and structural analysis of Bcp1 from Sulfolobus solfataricus
    Katia D'Ambrosio
    Istituto di Biostrutture e Bioimmagini CNR, Via Mezzocannone 16, 80134 Naples, Italy
    Proteins 76:995-1006. 2009
    Bcps constitute a group of antioxidant enzymes, belonging to the Prx family, that are widely distributed in bacteria, plants, and fungi. These proteins can contain two conserved cysteines within the CXXXXC motif...
  40. pmc Broad specificity AhpC-like peroxiredoxin and its thioredoxin reductant in the sparse antioxidant defense system of Treponema pallidum
    Derek Parsonage
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Proc Natl Acad Sci U S A 107:6240-5. 2010
    ..Although this Tp peroxiredoxin (Prx) closely resembles AhpC-like Prxs, Tp lacks AhpF, the typical reductant for such enzymes...
  41. doi Towards clarification of the inhibitory mechanism of wheat bran leachate on Microcystis aeruginosa NIES-843 (Cyanobacteria): physiological responses
    Jihai Shao
    Institute of Hydrobiology, Chinese Academy of Sciences, 430072 Wuhan, People s Republic of China
    Ecotoxicology 19:1634-41. 2010
    ..D1 protein of photosynthetic processes (psbA), synthesis of microcystins (mcyB), antioxidant protein peroxiredoxin (prx), synthesis of fatty acid (fabZ) and the repair of biological macromolecules (recA, grpE) were studied...
  42. ncbi Identification of a new type of mammalian peroxiredoxin that forms an intramolecular disulfide as a reaction intermediate
    M S Seo
    Laboratory of Cell Signaling and Department of Extramural Affairs, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 275:20346-54. 2000
    Peroxidases of the peroxiredoxin (Prx) family contain a Cys residue that is preceded by a conserved sequence in the NH(2)-terminal region...
  43. pmc Novel protective mechanism against irreversible hyperoxidation of peroxiredoxin: Nalpha-terminal acetylation of human peroxiredoxin II
    Jae Ho Seo
    School of Biological Sciences and Technology, Chonnam National University, Gwangju 500 757, Korea
    J Biol Chem 284:13455-65. 2009
    ..Our comparative study of hyperoxidation and regeneration of Prx I and Prx II in HeLa cells revealed that Prx II is more susceptible than Prx I to hyperoxidation and that the ..
  44. pmc A vacuolar class III peroxidase and the metabolism of anticancer indole alkaloids in Catharanthus roseus: Can peroxidases, secondary metabolites and arabinogalactan proteins be partners in microcompartmentation of cellular reactions?
    Mariana Sottomayor
    IBMC Instituto de Biologia Molecular e Celular Universidade do Porto Porto Portugal
    Plant Signal Behav 3:899-901. 2008
    ..Recently, in a classical function-to-protein-to-gene approach, we have characterized the main class III peroxidase (Prx) expressed in C. roseus leaves, CrPrx1, implicated in a key biosynthetic step of the anticancer alkaloids...
  45. doi Peroxiredoxin IV regulates pro-inflammatory responses in large yellow croaker (Pseudosciaena crocea) and protects against bacterial challenge
    Suhong Yu
    Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, State Oceanic Administration, Xiamen 361005, PR China
    J Proteome Res 9:1424-36. 2010
    ..Three Prx family members, namely, Prx I, Prx II, and Prx IV, were upregulated after treatment with the vaccine, indicating ..
  46. doi Evaluation of hepatic changes and local and systemic immune responses in goats immunized with recombinant Peroxiredoxin (Prx) and challenged with Fasciola hepatica
    Ricardo E Mendes
    Department of Anatomy and Comparative Pathology, School of Veterinary Medicine, University of Cordoba, Animal Health Building, Campus Rabanales, Cordoba, Spain
    Vaccine 28:2832-40. 2010
    Protection against Fasciola hepatica in goats immunized with Peroxiredoxin (Prx) was assessed...
  47. doi PRX-00023, a selective serotonin 1A receptor agonist, reduces ultrasonic vocalizations in infant rats bred for high infantile anxiety
    Susan A Brunelli
    Division of Developmental Neuroscience, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Pharmacol Biochem Behav 94:8-15. 2009
    ..infants (pups: Postnatal Day 11+/-1) were compared to those of randomly-bred controls in response to EPIX compound PRX-00023, a unique serotonin (5-HT) agonist, acting exclusively at the 5-HT1A receptor, or buspirone, a nonspecific ..
  48. ncbi Dual role of peroxiredoxin I in macrophage-derived foam cells
    James P Conway
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 281:27991-8001. 2006
    ..Specifically, our experiments have identified peroxiredoxin I (Prx I) as one of these up-regulated proteins...
  49. pmc Oxidation of archaeal peroxiredoxin involves a hypervalent sulfur intermediate
    Tsutomu Nakamura
    National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka 563 8577, Japan
    Proc Natl Acad Sci U S A 105:6238-42. 2008
    ..through a hypervalent sulfur intermediate by presenting crystallographic evidence from an archaeal peroxiredoxin (Prx), the thioredoxin peroxidase from Aeropyrum pernix K1 (ApTPx)...
  50. ncbi Induction of peroxiredoxin gene expression by oxygen in lungs of newborn primates
    K C Das
    Department of Molecular Biology, University of Texas Health Center at Tyler, Tyler, Texas 75708, USA
    Am J Respir Cell Mol Biol 25:226-32. 2001
    Peroxiredoxin (Prx) is an important antioxidant defense enzyme that reduces hydrogen peroxide to molecular oxygen by using reducing equivalents from thioredoxin...
  51. ncbi Differential protein expression of peroxiredoxin I and II by benzo(a)pyrene and quercetin treatment in 22Rv1 and PrEC prostate cell lines
    Amit Chaudhary
    Department of Pharmacology and Environmental Toxicology Research Program, School of Pharmacy, The University of Mississippi, 315 Faser Hall, Box 1848, University, MS 38677, USA
    Toxicol Appl Pharmacol 220:197-210. 2007
    ..Western blots confirmed that BaP increased peroxiredoxin (Prx) Prx I and decreased Prx II in 22Rv1 cells. Similar results were found in PrEC normal prostate epithelial cells...
  52. pmc COMe: the ontology of bioinorganic proteins
    Kirill Degtyarenko
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambs CB10 1SD, United Kingdom
    BMC Struct Biol 4:3. 2004
    ....
  53. ncbi Direct evidence for the formation of a complex between 1-cysteine peroxiredoxin and glutathione S-transferase pi with activity changes in both enzymes
    Luis A Ralat
    Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, USA
    Biochemistry 45:360-72. 2006
    Glutathione S-transferase pi (GST pi) has been shown to reactivate oxidized 1-cysteine peroxiredoxin (1-Cys Prx, Prx VI, Prdx6, and AOP2)...
  54. ncbi Molecular cloning, characterization and regulation of a peroxiredoxin gene from Schizosaccharomyces pombe
    Ga Young Kang
    Division of Life Sciences, College of Natural Sciences, Kangwon National University, 192 1 Hyoja 2 Dong, Chuncheon, Korea
    Mol Biol Rep 35:387-95. 2008
    A gene encoding a putative peroxiredoxin (Prx) of the fission yeast Schizosaccharomyces pombe was characterized and its regulation was studied...
  55. doi Cloning and functional characterization of a typical 2-Cys peroxiredoxin from southern bluefin tuna (Thunnus maccoyii)
    Drew L Sutton
    School of Biological Sciences, Flinders University, GPO Box 2100, Adelaide SA5001, Australia
    Comp Biochem Physiol B Biochem Mol Biol 156:97-106. 2010
    ..Here we describe the cloning and functional characterization of a Prx 2 cDNA from southern bluefin tuna (SBT, Thunnus maccoyii), an important aquaculture species in South Australia...
  56. pmc The effects of hexavalent chromium on thioredoxin reductase and peroxiredoxins in human bronchial epithelial cells
    Judith M Myers
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Free Radic Biol Med 47:1477-85. 2009
    ..The Trx's keep many intracellular proteins reduced, including the peroxiredoxins (Prx's)...
  57. ncbi The type II peroxiredoxin gene family of the mouse: molecular structure, expression and evolution
    M J Lim
    Molecular, Cellular Biology Research Division, Korea Research Institute of Bioscience, Biotechnology, PO Box 115, Yusong, Taejon 305 600, South Korea
    Gene 216:197-205. 1998
    ..We isolated genomic DNA sequences of the type II Prx (Prx II) gene from the mouse and analyzed their molecular genetic characteristics...
  58. ncbi Induction of heme-binding protein 23/peroxiredoxin I gene expression by okadaic acid in cultured rat hepatocytes
    Stephan Immenschuh
    Institut für Klinische Chemie und Pathobiochemie der Justus Liebig Universität Giessen, 35392 Giessen, Germany
    DNA Cell Biol 21:347-54. 2002
    Heme-binding protein 23 (HBP23), also termed peroxiredoxin I (Prx I), is an antioxidant protein that is induced by various oxidative stress stimuli...
  59. ncbi Reaction mechanism of plant 2-Cys peroxiredoxin. Role of the C terminus and the quaternary structure
    Janine König
    Biochemistry and Physiology of Plants, University of Bielefeld, Germany
    J Biol Chem 278:24409-20. 2003
    Barley 2-cysteine peroxiredoxin (2-Cys Prx) was analyzed for peroxide reduction, quaternary structure, thylakoid attachment, and function as well as in vivo occurrence of the inactivated form, with emphasis on the role of specific amino ..
  60. ncbi Disruption of the Plasmodium falciparum 2-Cys peroxiredoxin gene renders parasites hypersensitive to reactive oxygen and nitrogen species
    Kanako Komaki-Yasuda
    Research Institute, International Medical Center of Japan, 1 21 1 Toyama, Shinjuku ku, 162 8655, Tokyo, Japan
    FEBS Lett 547:140-4. 2003
    ..Peroxiredoxins (Prx) are ubiquitously distributed antioxidant enzymes...
  61. ncbi Biological effects of pramipexole on dopaminergic neuron-associated genes: relevance to neuroprotection
    Tianhong Pan
    Department of Neurology, Parkinson Disease Research Laboratory, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Neurosci Lett 377:106-9. 2005
    Pramipexole (PRX) is a non-ergot dopamine (DA) D2/D3 receptor agonist. Experimental studies have provided evidence that PRX may exert neuroprotective effects on the nigro-striatal system...
  62. ncbi Oxidative stress-dependent structural and functional switching of a human 2-Cys peroxiredoxin isotype II that enhances HeLa cell resistance to H2O2-induced cell death
    Jeong Chan Moon
    Environmental Biotechnology National Core Research Center, Division of Applied Life Sciences BK21 program, Department of Biochemistry, College of Medicine and Institute of Health Sciences, Gyeongsang National University, Jinju 660 701, Korea
    J Biol Chem 280:28775-84. 2005
    ..Here we demonstrated that human (h) PrxII, a cytosolic isotype of human 2-Cys Prx, has dual functions as a peroxidase and a molecular chaperone, and that these different functions are closely ..
  63. ncbi Tissue Prx I in the protection against Fe-NTA and the reduction of nitroxyl radicals
    Junya Uwayama
    Biomolecular and Integrated Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    Biochem Biophys Res Commun 339:226-31. 2006
    Peroxiredoxin I (Prx I) is a key cytoplasmic peroxidase that reduces intracellular hydroperoxides in concert with thioredoxin...
  64. ncbi Overexpression of mitochondrial peroxiredoxin-3 prevents left ventricular remodeling and failure after myocardial infarction in mice
    Shouji Matsushima
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Circulation 113:1779-86. 2006
    ..We hypothesized that overexpression of the mitochondrial antioxidant, peroxiredoxin-3 (Prx-3), could attenuate this deleterious process.
  65. ncbi The Prx Q protein of Arabidopsis thaliana is a member of the luminal chloroplast proteome
    Ulrika A Petersson
    Department of Biochemistry and Biophysics, Arrhenius Laboratories for Natural Sciences, Stockholm University, SE 106 91 Stockholm, Sweden
    FEBS Lett 580:6055-61. 2006
    ..The best-characterized member of the chloroplast peroxiredoxins is 2-Cys Prx that is associated with the stroma side of the thylakoid membrane and is considered to participate in antioxidant ..
  66. pmc TGF-beta signaling is essential for joint morphogenesis
    Anna Spagnoli
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Cell Biol 177:1105-17. 2007
    ..factor beta (TGF-beta) signaling in mice lacking the TGF-beta type II receptor gene (Tgfbr2) in their limbs (Tgfbr2(PRX-1KO))...
  67. ncbi Barbiturate therapy for patients with refractory intracranial hypertension following severe traumatic brain injury: its effects on tissue oxygenation, brain temperature and autoregulation
    J D Thorat
    Acute Brain Injury Research Laboratory, Department of Neurosurgery, Tan Tock Seng Hospital, National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore
    J Clin Neurosci 15:143-8. 2008
    ..explore the effects of barbiturate coma on cerebral tissue oxygen tension and cerebrovascular pressure reactivity (PRx), as an index of cerebral autoregulation in severe head injury patients...
  68. pmc Remodeling of motor nerve terminals in demyelinating axons of periaxin-null mice
    Felipe A Court
    Centre for Neuroscience Research, University of Edinburgh, Summerhall and George Square, Edinburgh EH8 9JZ, United Kingdom
    Glia 56:471-9. 2008
    ..Here we show that in mice lacking functional Periaxin (Prx) genes, a model of a recessive type of CMT disease known as CMT4F, neuromuscular junctions (NMJs) develop ..
  69. doi Proteome analysis of aflatoxin B1-induced hepatocarcinogenesis in tree shrew (Tupaia belangeri chinensis) and functional identification of candidate protein peroxiredoxin II
    Yuan Li
    Department of Experimental Pathology, Guangxi Cancer Institute, Nanning, China
    Proteomics 8:1490-501. 2008
    ..Peroxiredoxin (Prx) II, one of the candidates with distinct alteration, was further investigated and validated...
  70. doi Up-regulation of peroxiredoxin 1 in lung cancer and its implication as a prognostic and therapeutic target
    Joo Heon Kim
    Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Clin Cancer Res 14:2326-33. 2008
    Peroxiredoxin 1 and 2 are highly homologous members of the Prx (or Prdx) protein family. Prx1 and Prx2 are elevated in several human cancers, and this seems to confer increased treatment resistance and aggressive phenotypes...
  71. doi Identification of differentially expressed proteins in the heart of translationally controlled tumor protein over-expressing transgenic mice
    Myeong Sook Cheon
    Department of Herbal Resources Research, Korea Institute of Oriental Medicine, Daejeon 305 811, Korea
    Biomed Chromatogr 22:1091-9. 2008
    ..We determined protein expression levels of the peroxiredoxin (Prx)2, Prx3, myosin light chain 1, stress protein (heat shock protein) 25K, and T-complex protein 1 alpha subunit by ..
  72. doi Identification of potential serum markers for nasopharyngeal carcinoma from a xenografted mouse model using Cy-dye labeling combined with three-dimensional fractionation
    Chih Ching Wu
    Proteomics Core Laboratory, Chang Gung University, Tao Yuan, Taiwan, Republic of China
    Proteomics 8:3605-20. 2008
    ..We identified peroxiredoxin 2 (Prx-II) and carbonic anhydrase 2 (CA-II) as being elevated in the xenograft mouse model compared to controls...
  73. doi Peroxiredoxin-1 from Schistosoma japonicum functions as a scavenger against hydrogen peroxide but not nitric oxide
    Takashi Kumagai
    Section of Environmental Parasitology, Department of International Health Development, Division of Public Health, Tokyo Medical and Dental University Graduate School, Japan
    Mol Biochem Parasitol 164:26-31. 2009
    Three peroxiredoxins (Prxs) are expressed during most of the developmental stages in the schistosome. Prx-1 is localized on the surface of the schistosomula and adults of Schistosoma japonicum, while Prx-2 is localized in the sub-..
  74. doi Monitoring of cerebrovascular autoregulation: facts, myths, and missing links
    Marek Czosnyka
    Department of Clinical Neurosciences, Neurosurgical Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Neurocrit Care 10:373-86. 2009
    ..We review a methodology and clinical application of indices useful for monitoring cerebral autoregulation and pressure-reactivity in various scenarios of neuro-critical care...
  75. doi Prediction of outcome utilizing both physiological and biochemical parameters in severe head injury
    David Low
    Department of Neurosurgery, National Neuroscience Institute, Singapore
    J Neurotrauma 26:1177-82. 2009
    ..pressure (ICP), mean arterial pressure (MAP), cerebral perfusion pressure (CPP), and pressure reactivity index (PRx), as well as multimodal monitoring parameters to assess brain tissue oxygenation (PbtO(2)), and microdialysis ..
  76. ncbi Production and radioimmunoimaging of novel fully human phage display recombinant antibodies and growth inhibition of lung adenocarcinoma cell line overexpressing Prx I
    Yi Luo
    Department of Radiology, Chongqing Medical University, Chongqing, China
    Cancer Biol Ther 8:1369-77. 2009
    The Peroxiredoxin I (Prx I) is a member of the Peroxiredoxin family, which is overexpressed in many diverse tumor types and is an anti-apoptosis protein for tumor cell proliferation and survival...
  77. doi Cloning and characterization of peroxiredoxin in Babesia bovis
    Miho Tanaka
    National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080 8555, Japan
    Parasitol Res 105:1473-7. 2009
    We have identified the 2-Cys peroxiredoxin (Prx) from a bovine Babesia parasite, B. bovis. Prx is a recently described family of antioxidant enzymes that are highly conserved in eukaryotes and prokaryotes. B...
  78. doi Preferential overexpression of glutaredoxin3 in human colon and lung carcinoma
    Mee Kyung Cha
    Department of Biochemistry, Paichai University, Daejeon 302 735, Republic of Korea
    Cancer Epidemiol 33:281-7. 2009
    ..lung cancer tissues were significantly higher when compared to those of all thioredoxin (Trx) and peroxiredoxin (Prx) members...
  79. doi Highly expressed genes in a rough-colony-forming phenotype of Aggregatibacter actinomycetemcomitans: implication of a mip-like gene for the invasion of host tissue
    Takemasa Maeda
    Department of Patho physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    FEMS Immunol Med Microbiol 58:226-36. 2010
    ..technique, three genes, homologous to a macrophage infectivity potentiator gene (mip), peroxiredoxin gene (prx) and outer membrane protein gene (ompA), were identified...
  80. doi Enhanced tolerance of transgenic tall fescue plants overexpressing 2-Cys peroxiredoxin against methyl viologen and heat stresses
    Kyung Hee Kim
    Division of Applied Life Sciences, BK21 Program, IALS, PMBBRC, Gyeongsang National University, Jinju 660 701, Korea corrected
    Biotechnol Lett 32:571-6. 2010
    Plant 2-Cys peroxiredoxins (2-Cys Prx) has both peroxidase and chaperon function...
  81. pmc Alterations in brain antioxidant enzymes and redox proteomic identification of oxidized brain proteins induced by the anti-cancer drug adriamycin: implications for oxidative stress-mediated chemobrain
    G Joshi
    Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA Center of Membrane Sciences, University of Kentucky, Lexington, KY 40506, USA
    Neuroscience 166:796-807. 2010
    ..Triose phosphate isomerase (TPI), enolase, and peroxiredoxin 1 (PRX-1) showed significantly increased specific carbonylation in ADR treated mice brain...
  82. doi Proteomic analysis of lanthanum citrate-induced apoptosis in human cervical carcinoma SiHa cells
    Liming Shen
    College of Life Sciences, Shenzhen University, Shenzhen, 518060, People s Republic of China
    Biometals 23:1179-89. 2010
    ..Among them the alerted proteins, Prx I, ANXA1 and TRAF5 were validated by western blotting analyses...
  83. ncbi Proteomic profiles of mouse neuro N2a cells infected with variant virulence of rabies viruses
    Xiaohu Wang
    College of Animal Science and Veterinary Medicine, Jilin University, 5333 Xi an Road, Changchun 130062, China
    J Microbiol Biotechnol 21:366-73. 2011
    ..Specifically, a-enolase, prx-4, vimentin, cytokine-induced apoptosis inhibitor 1 (CIAPIN1) and prx-6 were significantly up-regulated, whereas ..
  84. doi Inactivation of a peroxiredoxin by hydrogen peroxide is critical for thioredoxin-mediated repair of oxidized proteins and cell survival
    Alison M Day
    Institute for Cell and Molecular Biosciences, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, Tyne and Wear, UK
    Mol Cell 45:398-408. 2012
    Eukaryotic 2-Cys peroxiredoxins (Prx) are abundant antioxidant enzymes whose thioredoxin peroxidase activity plays an important role in protecting against oxidative stress, aging, and cancer...
  85. pmc Potential relationship among three antioxidant enzymes in eliminating hydrogen peroxide in penaeid shrimp
    Dongdong Wang
    Experimental Marine Biology Laboratory, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, 266071, China
    Cell Stress Chaperones 17:423-33. 2012
    Antioxidant enzymes, such as glutathione peroxidase (GPx), catalase (CAT), and peroxiredoxin (Prx), are essential components in cells to eliminate excessive reactive oxygen species such as hydrogen peroxide (H(2)O(2))...
  86. doi Assessment of cerebral autoregulation from respiratory oscillations in ventilated patients after traumatic brain injury
    Philip M Lewis
    Department of Neurosurgery, Alfred Hospital, Prahran, Australia
    Acta Neurochir Suppl 114:141-6. 2012
    ..Monitored data were recorded and PS, TCD autoregulation (Mx) and pressure reactivity (PRx) were calculated using ICM+. PS was computed by peak detection in the ABP/CBFV cross-spectrum...
  87. doi The C-terminal extension of chloroplast 2-Cys peroxiredoxin is critical for interaction with ATP
    Diego Ferrero
    Instituto Leloir, IIBBA CONICET, Depto Química Biológica FCEN UBA, Patricias Argentinas 435, C1405BWE Buenos Aires, Argentina
    Biochemistry 51:2169-71. 2012
    ..Here, we reveal that the plant counterpart regulates the self-polymerization of 2-Cys Prx triggered by ATP and Mg(2+)...
  88. doi Insight into the solubility and dissolution behavior of piroxicam anhydrate and monohydrate forms
    Urve Paaver
    Department of Pharmacy, Faculty of Medicine, University of Tartu, Nooruse 1, 50411 Tartu, Estonia
    Int J Pharm 431:111-9. 2012
    ..sodium lauryl sulphate (SLS) on the solubility and dissolution rate of two solid-state forms of piroxicam (PRX), anhydrate (PRXAH) and monohydrate (PRXMH), and (2) to quantitatively assess the solid-phase transformation of ..
  89. pmc Electron transfer pathways and dynamics of chloroplast NADPH-dependent thioredoxin reductase C (NTRC)
    Pilar Bernal-Bayard
    Instituto de Bioquimica Vegetal y Fotosintesis, Consejo Superior de Investigaciones Cientificas and Universidad de Sevilla, cicCartuja, Seville, Spain
    J Biol Chem 287:33865-72. 2012
    ..features associated with the electron transfer to the thioredoxin module are altered in the presence of 2-Cys Prx. NTRC shows structural constraints that may locate the thioredoxin module in positions with different efficiencies ..
  90. pmc In the absence of thioredoxins, what are the reductants for peroxiredoxins in Thermotoga maritima?
    Jeremy Couturier
    Unité Mixte de Recherches 1136 INRA Lorraine Université, Interactions Arbres Microorganismes, IFR 110, Faculte des Sciences, Vandoeuvre Cedex, France
    Antioxid Redox Signal 18:1613-22. 2013
    ..Mutagenesis of the Prx-Ntr fusion, combined with kinetic and structural analyses, indicated that electrons are not transferred between its ..
  91. pmc Mapping the active site helix-to-strand conversion of CxxxxC peroxiredoxin Q enzymes
    Arden Perkins
    Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR 97331, USA
    Biochemistry 51:7638-50. 2012
    Peroxiredoxins (Prx) make up a family of enzymes that reduce peroxides using a peroxidatic cysteine residue; among these, members of the PrxQ subfamily are proposed to be the most ancestral-like yet are among the least characterized...
  92. doi Peroxiredoxin-2 represses melanoma metastasis by increasing E-Cadherin/β-Catenin complexes in adherens junctions
    Doo Jae Lee
    Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, Republic of Korea
    Cancer Res 73:4744-57. 2013
    ..Interestingly, the natural compound gliotoxin, which is known to exert a Prx-like activity, inhibited proliferation and migration as well as lung metastasis of Prx2-deficient melanoma cells...
  93. doi Characterization of a 2-Cys peroxiredoxin IV in Marsupenaeus japonicus (kuruma shrimp) and its role in the anti-viral immunity
    Xiao Wei Chen
    The Key Laboratory of Plant Cell Engineering and Germplasm Innovation of Ministry of Education, School of Life Sciences, Shandong University, 27 Shanda South Road, Jinan, Shandong 250100, China Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Sciences, Shandong University, 27 Shanda South Road, Jinan, Shandong 250100, China
    Fish Shellfish Immunol 35:1848-57. 2013
    Accumulating evidence suggests that peroxiredoxins (Prx) are key molecules in the pathogenesis of various infectious diseases and are potential therapeutic targets for major diseases such as cancers...
  94. doi Should the neurointensive care management of traumatic brain injury patients be individualized according to autoregulation status and injury subtype?
    Ulf Johnson
    Department of Neuroscience, Section of Neurosurgery, Uppsala University Hospital, 75185, Uppsala, Sweden
    Neurocrit Care 21:259-65. 2014
    ..Pressure reactivity index (PRx) is a measure of autoregulation that has been thoroughly studied, but little is known about its variation in ..
  95. doi Dominant role of peroxiredoxin/JNK axis in stemness regulation during neurogenesis from embryonic stem cells
    Sun Uk Kim
    Aging Research Center, Korea Research Institute of Bioscience and Biotechnology KRIBB, Daejeon, Republic of Korea Department of Functional Genomics, University of Science and Technology UST, Daejeon, Republic of Korea National Primate Research Center, KRIBB, Chungcheongbuk Do, Republic of Korea Division of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea
    Stem Cells 32:998-1011. 2014
    ..In this study, we demonstrate that peroxiredoxin (Prx) plays a pivotal role in maintenance of ESC stemness during neurogenesis through suppression of reactive oxygen ..
  96. doi Characterization and expression analysis of peroxiredoxin family genes from the silkworm Bombyx mori in response to phoxim and chlorpyrifos
    Gui Qin Shi
    The College of Food and Biological Engineering, Zhengzhou University of Light Industry, Zhengzhou 450002, China Electronic address
    Pestic Biochem Physiol 114:24-31. 2014
    ..Here, five peroxiredoxin (Prx) genes have been identified in silkworm genome, and Prx genes of silkworm and mammalian homologs have apparent ..
  97. doi Induced systemic resistance responses in perennial ryegrass against Magnaporthe oryzae elicited by semi-purified surfactin lipopeptides and live cells of Bacillus amyloliquefaciens
    Alamgir Rahman
    Department of Plant Pathology and Environmental Microbiology, The Pennsylvania State University, University Park, PA, 16802, USA
    Mol Plant Pathol 16:546-58. 2015
    ..Moreover, a hypersensitive response (HR)-type reaction and enhanced expression of LpPrx (Prx, peroxidase), LpOXO4 (OXO, oxalate oxidase), LpPAL (PAL, phenylalanine ammonia lyase), LpLOXa (LOX, lipoxygenase), ..
  98. doi Multiparameter-based bioassay of 2-(4-chlorophenyl)-4-(4-methoxyphenyl) quinazoline, a newly-synthesized quinazoline derivative, toward Microcystis aeruginosa HAB5100 (cyanobacteria)
    Yang Zhao
    Key Laboratory of Functional Small Organic Molecules, Ministry of Education and College of Life Science, Jiangxi Normal University, Nanchang, 330022, Jiangxi, China
    Bull Environ Contam Toxicol 94:376-81. 2015
    ..Growth was inhibited by CMQ, with a 96 h EC50 of 1.93 ± 0.19 mg L(-1). The up-regulated expression of prx was shown, reflecting that oxidative stress might be a toxic factor of CMQ...
  99. doi The Effect of Red Blood Cell Transfusion on Cerebral Autoregulation in Patients with Severe Traumatic Brain Injury
    Mypinder S Sekhon
    Division of Critical Care Medicine, Department of Medicine, Vancouver General Hospital, University of British Columbia, West 12th Avenue, Vancouver, BC, V5Z 1M9, Canada
    Neurocrit Care 23:210-6. 2015
    ..Previous studies have failed to consider alterations in cerebral autoregulation. Our objective was to investigate the effect of RBC transfusion on cerebral autoregulation, as measured by pressure reactivity index (PRx).
  100. pmc Site-directed mutagenesis substituting cysteine for serine in 2-Cys peroxiredoxin (2-Cys Prx A) of Arabidopsis thaliana effectively improves its peroxidase and chaperone functions
    Eun Mi Lee
    Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, 29 Geumgu gil, Jeongeup 580 185, Republic of Korea
    Ann Bot 116:713-25. 2015
    The 2-Cys peroxiredoxin (Prx) A protein of Arabidopsis thaliana performs the dual functions of a peroxidase and a molecular chaperone depending on its conformation and the metabolic conditions...
  101. pmc Mitochondrial Respiratory Chain Inhibitors Involved in ROS Production Induced by Acute High Concentrations of Iodide and the Effects of SOD as a Protective Factor
    Lingyan Wang
    Department of Pathophysiology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China
    Oxid Med Cell Longev 2015:217670. 2015
    ..of the mitochondrial fluorescent probe, MitoSOX Red, western blot of mitochondrial ROS scavenger Peroxiredoxin (Prx) 3 and fluorescence immunostaining, ELISA of cleaved caspases 3 and 9, and TUNEL staining, we demonstrated that ..

Research Grants24

  1. Mechanistic Studies of Alkyl Hydroperoxide Reductase and Related Redox Proteins
    Leslie B Poole; Fiscal Year: 2013
    ..We have developed expertise in Prx enzymology over more than 15 years of characterizing of Prxs from pathogenic bacteria (e.g...
  2. W Todd Lowther; Fiscal Year: 2014
    ..We have shown that Srx utilizes a novel nucleotide binding motif and sulfur chemistry to reduce the Prx molecule and were able to identify critical kinetic intermediates in the repair of hyperoxidized PrxII by Srx...
  3. Mark S Nanes; Fiscal Year: 2014
    ..3Cola1Cre X TgTNF). The effect of Prx knockout in bone on the extent of bone loss, erosions, and inflammation will be determined in the TNF expressing ..
  4. Aron B Fisher; Fiscal Year: 2016
    ..factor Nrf2, and have developed a model based on lipid binding studies for the coordination of the peroxidase (Prx) and phospholipase (PLA2) activities of the protein. We are now seeking 5 years of support to extend these studies...
  5. Prx1 in malignant progression of prostate cancer
    Candace S Johnson; Fiscal Year: 2010
    ..However, the effects of Prx expression in human cancers, their influence on cancer therapy, and the regulatory basis of their expression in ..
  6. Redox control of CD8 T cell proliferation, differentiation and death
    JASON MITCHELL GRAYSON; Fiscal Year: 2012
    ..TCR transgenic mice that overexpress both catalase and Cu superoxide dismutase (CAT/SOD) or lack peroxiredoxin II (Prx II -/-) will be used...
  7. Fiber Cell Cytoskeletal Scaffolds-Role in Lens Architecture and Function
    P Vasantha Rao; Fiscal Year: 2011
    ..This proposal will investigate the function(s) of the PDZ domain protein-Periaxin, a component of the major cortical adhesive complex-EPPD (ezrin-periaxin-periplakin-desmoyokin) in lens fiber ..
  8. Cyclooxygenases in Skeletal Repair
    Xinping Zhang; Fiscal Year: 2013
    ..In Aim1, we will characterizes fracture healing in COX-2f/f;Prx-1Cre and EP4f/-;Prx1Cre mice, in which COX-2 or EP4 receptor are deleted in mesenchymal cells or chondrocytes ..
  9. NEW HOMEBOX GENES IN SCARLESS FETAL WOUND HEALING
    Corey Largman; Fiscal Year: 2001
    ..They have cloned two new homeobox genes (PRX-2 and HOXB13) from regenerating wounded human fetal skin which met criteria for influencing fetal skin regeneration...
  10. HTS Inhibitors:Schistosoma Mansoni Peroxiredoxins(RMI)
    David Williams; Fiscal Year: 2005
    ..Schistosoma mansoni peroxiredoxins (Prx) are important parasite antioxidant proteins that play a crucial role in redox balance mechanisms...
  11. Glutathione S-Transferases: Novel Regulators of Cellular Stress and Apoptosis
    ROBERTA COLMAN; Fiscal Year: 2009
    ..the cellular response to oxidative stress, since GSTpi activates the anti-oxidant enzyme 1-Cys peroxiredoxin (1-Cys Prx);and GSTs influence cell signaling through interactions with Jun N-terminal Kinase (JNK) and Apoptosis Signal-..
  12. Prx homebox genes in pulmonary vascular homeostasis
    Peter Jones; Fiscal Year: 2006
    ..These findings support the general hypotheses that Prx genes are regulated by changes in cell adhesion to the ECM, and that Prx proteins play key roles in remodeling PM ..
  13. Phthalate-induced testicular mitochondrial dysfunction
    THOMAS ONORATO; Fiscal Year: 2005
    ..objective are to: (1) test the postulate that MEHP affects testicular expression of the antioxidant peroxiredoxins (Prx), (2) determine whether MEHP exposure leads to Prx3 inactivation in GC, but not in SC, (3) establish whether Prx3 ..
  14. Peroxiredoxin 1 in radiotherapy of lung cancer
    Young Mee Park; Fiscal Year: 2007
    ..However, the effects of Prx expression in human cancers, their influence on cancer therapy, and the regulatory basis for their expression in ..
  15. OUTER MEMBRANE CYTOCHROMES--TOPOLOGY AND FUNCTION
    Charles Myers; Fiscal Year: 2002
    ..They will also contribute to environmental health by expanding our knowledge on the mechanisms by which manganese, iron, and various heavy metals are mobilized into water supplies. ..
  16. A gene map for Biomphalaria glabrata, a S. mansoni host
    Matty Knight; Fiscal Year: 2009
    ..glabrata genome. ..
  17. Human Lung Chromium Toxicity: Role of cytochrome b5
    Charles Myers; Fiscal Year: 2007
    ..They will provide a deeper understanding of the mechanisms underlying Cr(VI) toxicity in human lung, and will lead to new insights on the role of b5 in toxicant activation [unreadable] [unreadable]..
  18. MOLECULAR BASIS OF HEREDITARY NEURALGIC AMYOTROPHY
    PHILLIP CHANCE; Fiscal Year: 2008
    ..Moreover, characterization of the HNA gene may have broader pathophysiological and therapeutic implications for more common idiopathic forms of brachial neuropathy. [unreadable] [unreadable]..
  19. Role of P-gp in perivascular HIV-1 sanctuary and HAART
    Debasis Mondal; Fiscal Year: 2007
    ..The proposed studies are expected to provide exploratory new information on existence of a perivascular endothelial barrier that may compromise the effectiveness of Pis and allow development of an HTV-1 sanctuary. ..
  20. Identification and characterization of the ALS4 gene
    PHILLIP CHANCE; Fiscal Year: 2006
    ..Specific Aim (5) is to develop an animal model of ALS4 by introducing an identified disease-causing mutation into the germline of the mouse by employing either transgenesis or gene targeting. ..
  21. Redox control of Nrf2/ARE by thioredoxin and GSH
    Jason Hansen; Fiscal Year: 2005
    ..The roles of GSH and cytosolic and nuclear TRX during NRF2 activation and binding will provide an essential foundation for future developmental toxicology. ..
  22. PROTON MRS STUDIES IN GENERALIZED ANXIETY DISORDER
    Sanjay Mathew; Fiscal Year: 2008
    ..A specific long-term goal is for the candidate to develop sufficient expertise in MRS to sustain valid and creative application to problems of GAD and related conditions. ..
  23. TGF-beta Signaling in Mesenchymal Chondroprogenitors
    Anna Spagnoli; Fiscal Year: 2007
    ..Understanding the role of TGF-beta in MCC biology will provide a framework for therapeutic manipulations to optimize the use of MCC in cartilage diseases. ..
  24. MACROPHAGES, DENDRITIC CELLS AND PATHOGENS
    Carl Nathan; Fiscal Year: 2007
    ..Cores provide for BSL3 wet lab and mouse work; microarray analysis of gene expression; computation and comparison of gene expression results; and high throughput screening of chemical libraries. ..