prolactin

Summary

Gene Symbol: prolactin
Description: prolactin
Alias: GHA1, prolactin, decidual prolactin, growth hormone A1
Species: human

Top Publications

  1. ncbi Stimulation of interferon regulatory factor-1 by prolactin
    L Yu-Lee
    Department of Medicine, Cell and Molecular Biology Program, Baylor College of Medicine, Houston, Texas 77030, USA
    Lupus 10:691-9. 2001
  2. pmc TGFβ1 attenuates expression of prolactin and IGFBP-1 in decidualized endometrial stromal cells by both SMAD-dependent and SMAD-independent pathways
    Nicole M Kane
    Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, Queen s Medical Research Institute, Edinburgh, Scotland, United Kingdom
    PLoS ONE 5:e12970. 2010
  3. pmc Bone morphogenetic protein 1 processes prolactin to a 17-kDa antiangiogenic factor
    Gaoxiang Ge
    Department of Pathology and Laboratory Medicine, University of Wisconsin, 1300 University Avenue, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 104:10010-5. 2007
  4. ncbi Coactivation of janus tyrosine kinase (Jak)1 positively modulates prolactin-Jak2 signaling in breast cancer: recruitment of ERK and signal transducer and activator of transcription (Stat)3 and enhancement of Akt and Stat5a/b pathways
    Lynn M Neilson
    Kimmel Cancer Center, Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Mol Endocrinol 21:2218-32. 2007
  5. ncbi Induction of GH, PRL, and TSH beta mRNA by transfection of Pit-1 in a human pituitary adenoma-derived cell line
    Shunsuke Miyai
    Department of Pathology, Tokai University School of Medicine, Bohseidai Isehara Campus, Kanagawa 259 1193, Japan
    Cell Tissue Res 322:269-77. 2005
  6. ncbi Nonpituitary human prolactin gene transcription is independent of Pit-1 and differentially controlled in lymphocytes and in endometrial stroma
    B Gellersen
    Institute for Hormone and Fertility Research, University of Hamburg, Germany
    Mol Endocrinol 8:356-73. 1994
  7. ncbi Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice
    C Bole-Feysot
    INSERM Unité 344 Endocrinologie Moléculaire, Faculte de Medecine Necker, Paris, France
    Endocr Rev 19:225-68. 1998
  8. ncbi Endogenous human prolactin and not exogenous human prolactin induces estrogen receptor alpha and prolactin receptor expression and increases estrogen responsiveness in breast cancer cells
    Jennifer H Gutzman
    Department of Comparative Biosciences, 2015 Linden Drive, University of Wisconsin Madison, Madison, WI 53706, USA
    J Steroid Biochem Mol Biol 88:69-77. 2004
  9. ncbi Identification of prolactin as a novel immunomodulator on the expression of co-stimulatory molecules and cytokine secretions on T and B human lymphocytes
    Karina Chavez-Rueda
    Laboratorio de Auto inmunidad, Unidad de Investigación Médica en Inmunología, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, D F, Mexico
    Clin Immunol 116:182-91. 2005
  10. ncbi Association of prolactin and its receptor gene regions with familial breast cancer
    Annika Vaclavicek
    Division of Molecular Genetic Epidemiology C050, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    J Clin Endocrinol Metab 91:1513-9. 2006

Research Grants

  1. Prolactin as a Growth Factor in Breast Cancer
    Nira Ben-Jonathan; Fiscal Year: 2013
  2. Tyrosine Phosphyorylation and Growth Hormone Signaling
    STUART FRANK; Fiscal Year: 2005
  3. Maria Diakonova; Fiscal Year: 2014
  4. SUZANNE MARIE SCHAUWECKER; Fiscal Year: 2015
  5. Stability of prolactin receptor and prolactin signaling
    Serge Y Fuchs; Fiscal Year: 2010
  6. ENDOCRINE REGULATION OF MATERNAL BEHAVIOR
    Robert Bridges; Fiscal Year: 2009
  7. CRAIG BARCUS; Fiscal Year: 2015
  8. Experimental Modeling of Human Breast Cancer in Mice
    Hallgeir Rui; Fiscal Year: 2012
  9. Christin Carter-Su; Fiscal Year: 2016
  10. Effects of Chronic Estrogen on TIDA Neurons: Role of Cytokines and NO
    Puliyur S MohanKumar; Fiscal Year: 2010

Detail Information

Publications563 found, 100 shown here

  1. ncbi Stimulation of interferon regulatory factor-1 by prolactin
    L Yu-Lee
    Department of Medicine, Cell and Molecular Biology Program, Baylor College of Medicine, Houston, Texas 77030, USA
    Lupus 10:691-9. 2001
    b>Prolactin (PRL), a pituitary peptide hormone, is known to regulate diverse cellular functions including proliferation, differentiation, angiogenesis and protection against apoptosis and inflammation...
  2. pmc TGFβ1 attenuates expression of prolactin and IGFBP-1 in decidualized endometrial stromal cells by both SMAD-dependent and SMAD-independent pathways
    Nicole M Kane
    Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, Queen s Medical Research Institute, Edinburgh, Scotland, United Kingdom
    PLoS ONE 5:e12970. 2010
    ..A role for TGFβ1 in decidualization remains to be established and published data concerning effects of TGFβ1 on markers of endometrial decidualization are inconsistent...
  3. pmc Bone morphogenetic protein 1 processes prolactin to a 17-kDa antiangiogenic factor
    Gaoxiang Ge
    Department of Pathology and Laboratory Medicine, University of Wisconsin, 1300 University Avenue, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 104:10010-5. 2007
    ..and placenta and functions in growth and reproduction, members of the small family of hormones that includes prolactin (PRL), growth hormone (GH), and placental lactogen are expressed by endothelia and have angiogenic effects...
  4. ncbi Coactivation of janus tyrosine kinase (Jak)1 positively modulates prolactin-Jak2 signaling in breast cancer: recruitment of ERK and signal transducer and activator of transcription (Stat)3 and enhancement of Akt and Stat5a/b pathways
    Lynn M Neilson
    Kimmel Cancer Center, Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Mol Endocrinol 21:2218-32. 2007
    b>Prolactin (PRL) receptors (PRLRs) have been considered selective activators of Janus tyrosine kinase (Jak)2 but not Jak1, Jak3, or Tyk2...
  5. ncbi Induction of GH, PRL, and TSH beta mRNA by transfection of Pit-1 in a human pituitary adenoma-derived cell line
    Shunsuke Miyai
    Department of Pathology, Tokai University School of Medicine, Bohseidai Isehara Campus, Kanagawa 259 1193, Japan
    Cell Tissue Res 322:269-77. 2005
    ..Pituitary-specific transcription factor-1 (Pit-1) is required for the expression of growth hormone (GH), prolactin (PRL), and the thyroid-stimulating hormone beta subunit (TSH beta) and acts synergistically with the estrogen ..
  6. ncbi Nonpituitary human prolactin gene transcription is independent of Pit-1 and differentially controlled in lymphocytes and in endometrial stroma
    B Gellersen
    Institute for Hormone and Fertility Research, University of Hamburg, Germany
    Mol Endocrinol 8:356-73. 1994
    ....
  7. ncbi Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice
    C Bole-Feysot
    INSERM Unité 344 Endocrinologie Moléculaire, Faculte de Medecine Necker, Paris, France
    Endocr Rev 19:225-68. 1998
    ..On the other hand, many of the effects reported in this review may be shared with other hormones, cytokines, or growth factors and thus will be more difficult to study. (ABSTRACT TRUNCATED)..
  8. ncbi Endogenous human prolactin and not exogenous human prolactin induces estrogen receptor alpha and prolactin receptor expression and increases estrogen responsiveness in breast cancer cells
    Jennifer H Gutzman
    Department of Comparative Biosciences, 2015 Linden Drive, University of Wisconsin Madison, Madison, WI 53706, USA
    J Steroid Biochem Mol Biol 88:69-77. 2004
    b>Prolactin (PRL) and estrogen act synergistically to increase mammary gland growth, development, and differentiation...
  9. ncbi Identification of prolactin as a novel immunomodulator on the expression of co-stimulatory molecules and cytokine secretions on T and B human lymphocytes
    Karina Chavez-Rueda
    Laboratorio de Auto inmunidad, Unidad de Investigación Médica en Inmunología, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, D F, Mexico
    Clin Immunol 116:182-91. 2005
    We investigate the immunomodulator role of prolactin (PRL) on CD4+ and B cell activation from healthy subjects in comparison with hyperprolactinemic patients...
  10. ncbi Association of prolactin and its receptor gene regions with familial breast cancer
    Annika Vaclavicek
    Division of Molecular Genetic Epidemiology C050, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    J Clin Endocrinol Metab 91:1513-9. 2006
    The contribution of prolactin (PRL) through its receptor (PRLR) to the pathogenesis and progression of human mammary tumors has received recent attention.
  11. pmc Human scalp hair follicles are both a target and a source of prolactin, which serves as an autocrine and/or paracrine promoter of apoptosis-driven hair follicle regression
    Kerstin Foitzik
    Department of Dermatology, University Hospital Hamburg Eppendorf, University of Hamburg, Hamburg, Germany
    Am J Pathol 168:748-56. 2006
    The prototypic pituitary hormone prolactin (PRL) exerts a wide variety of bioregulatory effects in mammals and is also found in extrapituitary sites, including murine skin...
  12. pmc Prolactin release by adipose explants, primary adipocytes, and LS14 adipocytes
    Eric R Hugo
    Department of Cell and Cancer Biology, University of Cincinnati, Cincinnati, Ohio 45267 0521, USA
    J Clin Endocrinol Metab 93:4006-12. 2008
    b>Prolactin (PRL) is a multifunctional hormone produced in humans by both pituitary and extrapituitary sites, including adipose tissue.
  13. ncbi Binding of a 100-kDa ubiquitous factor to the human prolactin promoter is required for its basal and hormone-regulated activity
    B Peers
    Laboratoire de Biologie Moléculaire et de Génie Génétique, Institut de Chimie, Universite de Liege, Belgium
    Eur J Biochem 210:53-8. 1992
    cAMP strongly stimulates the activity of the human prolactin (hPRL) promoter...
  14. ncbi Bone marrow stroma-derived prolactin is involved in basal and platelet-activating factor-stimulated in vitro erythropoiesis
    G Bellone
    Department of Clinical Physiopathology, University of Turin, Italy
    Blood 90:21-7. 1997
    Cooperation between in vitro exogenous prolactin (PRL), granulocyte-macrophage colony-stimulating factor (GM-CSF), and interleukin-3 (IL-3) at an early step of in vitro erythroid differentiation has been shown in a previous study...
  15. ncbi Expression of the prolactin gene in normal and neoplastic human breast tissues and human mammary cell lines: promoter usage and alternative mRNA splicing
    C M Shaw-Bruha
    Eppley Institute for Research in Cancer and Allied Diseases, Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha 68198 6805, USA
    Breast Cancer Res Treat 44:243-53. 1997
    b>Prolactin (PRL) has been implicated in the development of mammary cancer in rodents and humans...
  16. ncbi Characterization of a prolactin gene polymorphism and its associations with systemic lupus erythematosus
    A Stevens
    University of Manchester, UK
    Arthritis Rheum 44:2358-66. 2001
    Hyperprolactinemia is associated with systemic lupus erythematosus (SLE), but the mechanism is unknown. Prolactin is expressed in T lymphocytes and is under the control of an alternative promoter region...
  17. ncbi Polymorphisms of the human prolactin gene--implications for production of lymphocyte prolactin and systemic lupus erythematosus
    A Stevens
    Endocrine Sciences Research Group, University of Manchester, UK
    Lupus 10:676-83. 2001
    Hyperprolactinaemia is associated with systemic lupus erythematosus (SLE) but the mechanism is unknown. Prolactin is expressed not only by pituitary lactotrophic cells but also by T-lymphocytes under the control of an alternative ..
  18. ncbi Human prolactin and its antagonist, hPRL-G129R, regulate bax and bcl-2 gene expression in human breast cancer cells and transgenic mice
    Susan K Peirce
    Department of Genetics and Biochemistry, Clemson University, Clemson, SC 29630, USA
    Oncogene 23:1248-55. 2004
    To gain insight into the molecular mechanisms involved in human prolactin receptor antagonist (hPRL-G129R)-induced apoptosis, we used real-time reverse transcription-polymerase chain reaction to measure bax and bcl-2 gene expression in ..
  19. pmc Human prolactin gene promoter regulation by estrogen: convergence with tumor necrosis factor-alpha signaling
    A D Adamson
    Endocrine Sciences Research Group, School of Clinical and Laboratory Sciences, University of Manchester, Core Technology Facility 3rd floor, Manchester, UK
    Endocrinology 149:687-94. 2008
    Estrogens have been implicated in the regulation of prolactin gene expression in man, although previous studies have not defined the molecular mechanism whereby estradiol activates the human prolactin gene promoter (hPrl)...
  20. doi Prolactin stimulates ubiquitination, initial internalization, and degradation of its receptor via catalytic activation of Janus kinase 2
    Gayathri Swaminathan
    Department of Animal Biology and Mari Lowe Center for Comparative Oncology Research Cell, University of Pennsylvania, 380 S University Avenue, Philadelphia, Pennsylvania 19104, USA
    J Endocrinol 196:R1-7. 2008
    b>Prolactin (PRL) activates its receptor to initiate signal transduction pathways (including activation of Janus kinases, Jak) but also stimulates downregulation of this receptor to limit the magnitude and duration of signaling...
  21. doi Prolactin and preclinical atherosclerosis in menopausal women with cardiovascular risk factors
    George A Georgiopoulos
    Department of Therapeutics, Alexandra Hospital, Athens University Medical School, Greece
    Hypertension 54:98-105. 2009
    ..and an adverse cardiovascular risk profile, possibly as a result of the vasoconstrictive properties of prolactin. In this cross-sectional study, we examined the hypothesis that prolactin contributes to the increased ..
  22. ncbi Human prolactin gene expression. The use of an alternative noncoding exon in decidua and the IM-9-P3 lymphoblast cell line
    G E DiMattia
    Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    J Biol Chem 265:16412-21. 1990
    The prolactin (PRL) gene is normally expressed in the anterior pituitary lactotrope and the decidualized stromal cell of the human endometrium...
  23. pmc Isolation and characterization of the human prolactin gene
    A T Truong
    EMBO J 3:429-37. 1984
    b>Prolactin (PRL) and growth hormone (GH) genes derive from a common ancestor and still share some sequence homologies. Their expression in the pituitary gland is regulated in opposite directions by most of the many hormones acting on them...
  24. ncbi Evaluation of hypothalamic-pituitary-adrenocortical hormones and inflammatory cytokines in patients with persistent vegetative state
    I Munno
    Department of Internal Medicine, Immunology and Infectious Diseases, University of Bari, Italy
    Immunopharmacol Immunotoxicol 20:519-29. 1998
    Hypothalamic-pituitary-adrenocortical hormones, i.e. prolactin (PRL), human growth hormone (hGH), thyroid stimulating hormone (TSH), and Cortisol and plasma levels of cytokines, i.e...
  25. ncbi Streptozotocin-diabetes impairs prolactin binding to Leydig cells in prepubertal and pubertal rats
    S Sudha
    Department of Endocrinology, Dr. A.L.M. Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai, India
    Horm Metab Res 31:583-6. 1999
    b>Prolactin (PRL) binding to Leydig cells in prepubertal and pubertal streptozotocin (STZ)-diabetic and insulin-treated rats was studied...
  26. ncbi Morphological changes in the pituitary gland of dogs chronically exposed to exogenous growth hormone
    P Laroque
    Merck Sharp and Dohme Chibret Laboratories, Department of Safety Assessment, Riom, France
    Toxicol Pathol 26:201-6. 1998
    ..distalis were quantitated by a point counting method following immunostaining to identify cells containing GH, prolactin (PRL), and adrenocorticotrophic (ACTH) hormones...
  27. ncbi Ultrastructural and immunoelectron microscopic study of three unusual plurihormonal pituitary adenomas
    S Vidal
    Department of Laboratory Medicine and Pathobiology, St Michael s Hospital, University of Toronto, Canada
    Ultrastruct Pathol 23:141-8. 1999
    ..Immunocytochemistry revealed variable degrees of immunoreactivities for growth hormone (GH), prolactin (PRL), thyroid-stimulating hormone (beta-TSH), and alpha-subunit of glycoprotein hormones in all three tumors...
  28. ncbi Effects of the short-acting benzodiazepine triazolam, taken at bedtime, on circadian and sleep-related hormonal profiles in normal men
    G Copinschi
    School of Medicine, Free University of Brussels, Belgium
    Sleep 13:232-44. 1990
    ..In each study, sleep was polygraphically monitored and plasma cortisol, growth hormone (GH), melatonin, and prolactin (PRL) (i.e...
  29. ncbi Influence of paroxetine, branched-chain amino acids and tyrosine on neuroendocrine system responses and fatigue in humans
    H K Struder
    Institute of Sports Games, German Sport University, Koln
    Horm Metab Res 30:188-94. 1998
    ..Plasma prolactin (PRL), growth hormone, cortisol, adrenocorticotropic hormone, norepinephrine and epinephrine increased during ..
  30. ncbi Serum levels of insulin-like growth factor-I in operable breast cancer in relation to the main prognostic variables and their perioperative changes in relation to those of prolactin
    S Barni
    Divisione di Radioterapia Oncologica, Polo Universitario di Monza, Ospedale S. Gerardo, Milano, Italy
    Tumori 80:212-5. 1994
    AIMS AND BACKGROUND: In addition to estrogens, prolactin (PRL) and IGF-I have also appeared to stimulate breast cancer growth...
  31. ncbi Calcium and prolactin secretion in humans: effects of the channel blocker, verapamil, in the spontaneous and drug-induced hyperprolactinemia
    M Knoepfelmacher
    Endocrine Service, Hospital das Clinicas, , Brazil
    Horm Metab Res 26:481-5. 1994
    ..0833 mg/min for 2-3 h after a 5 mg bolus) on prolactin (PRL) and thyrotropin (TSH) circulating levels were assessed in 7 normal subjects and in 17 patients with ..
  32. ncbi Alpha 2-adrenoceptor-mediated inhibition of prolactin release in suckling- or fenfluramine-induced hyperprolactinemia
    P Navarra
    Laboratory of Normal and Pathological Physiology, State University of Ghent, Belgium
    Horm Metab Res 23:213-7. 1991
    It has recently been shown that the specific and selective alpha 2-antagonist idazoxan (IDZ) displays prolactin-lowering activity on hyperprolactinemia induced in the rat either by suckling or serotonergic drugs...
  33. ncbi Endocrinological study of the dopaminergic regulation of prolactin release in metastatic breast cancer
    M Mandala
    Divisione di Radioterapia Oncologica, Ospedale San Gerardo, Monza, Italy
    Tumori 85:494-7. 1999
    b>Prolactin (PRL) may be a growth factor for breast cancer. Abnormally high levels of PRL have been proven to be associated with a poor prognosis in metastatic breast cancer...
  34. ncbi Hyperprolactinemia and luteal insufficiency in infertile patients with mild and minimal endometriosis
    J S Cunha-Filho
    Obstetrics and Gynecology Department, , Universidade Federal do Rio Grande do Sul, Brazil
    Horm Metab Res 33:216-20. 2001
    ..Six infertile patients with endometriosis presented prolactin levels above 20 ng/ml. This was not observed in the other groups...
  35. ncbi Effects of bromocriptine treatment on immune responses and 3-methylcholanthrene-induced tumorigenesis in rats
    J L Bussiere
    Department of Microbiology and Immunology, School of Medicine, Temple University, Philadelphia, PA 19140
    Immunopharmacol Immunotoxicol 13:47-64. 1991
    ..Animals treated with the two high doses of BCR had decreased serum prolactin (PRL) levels...
  36. ncbi Bone mineral content of the hyperprolactinemic rat femur by single photon absorptiometry
    C E Fiore
    Department of Medical Pathology, University of Catania, Italy
    Horm Metab Res 20:40-3. 1988
    ..This experimental model was set to evaluate the influence that high prolactin levels may have on bone mineralization when an intervention of estrogens can reasonably be excluded...
  37. ncbi The pituitary-thyroid axis in acromegaly
    P C Eskildsen
    Medical Endocrinological Department F, Fredericksborg County Hospital, , Denmark
    Horm Metab Res 20:755-7. 1988
    ..of thyroxine (T4), triiodothyronine (T3) and reverse T3 (rT3) and thyrotropin (TSH), growth hormone (GH) and prolactin (PRL) before and after iv stimulation with thyrotropin releasing hormone (TRH)...
  38. ncbi Studies on the mechanism by which prolactin stimulates alpha-aminoisobutyric acid uptake into cultured mouse mammary tissues
    K Golden
    Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan
    Horm Metab Res 25:466-9. 1993
    ..the possible roles of the polyamines, cyclic nucleotides, icosanoid products, and protein kinase C in the prolactin regulation of amino acid transport in cultured mammary gland explants derived from 12-14 day pregnant mice...
  39. ncbi Sequence of prolactin effects on phospholipid synthesis in mouse mammary gland explants
    J A Rillema
    Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan
    Horm Metab Res 22:12-6. 1990
    In cultured mouse mammary gland explants derived from 12-14 day pregnant mice, the effect of prolactin (PRL) on the rate of incorporation of several precursors into neutral lipids and phospholipids was determined...
  40. ncbi Increase of serum somatomedin C in hyperthyroid patients with pregnancy
    S Suzuki
    Department of Gerontology, Endocrinology and Metabolism, School of Medicine, Shinshu University, Naganoken, Japan
    Horm Metab Res 24:78-81. 1992
    ..treated for hyperthyroidism, and since human placental lactogen (HPL), human chorionic gonadotropin (HCG) and prolactin (PRL) do not crossreact with SmC antibody, it is suggested that excess thyroid hormone during pregnancy results ..
  41. ncbi The effects of the degree of surgical trauma and glucose load on concentration of thyrotropin, growth hormone and prolactin under enflurane anaesthesia
    M Redondo
    Biochemistry Department, Medical School, , Spain
    Horm Metab Res 29:66-9. 1997
    ....
  42. ncbi The pituitary-thyroid axis in patients with pituitary disorders
    P C Eskildsen
    Medical Department, Horsens Hospital, Denmark
    Horm Metab Res 21:387-90. 1989
    ..The examination also included measurement of prolactin (PRL) and cortisol (C) in serum...
  43. ncbi Further evidence that prolactin does not affect gonadotropin release at pituitary level
    W D Hetzel
    Abteilung Innere Medizin I, Medizinische Klinik und Poliklinik, , Germany
    Horm Metab Res 19:555-62. 1987
    ..LH secretion even after a preincubation period of up to 6 hrs and at concentrations generally observed for prolactin secreting tumors. Bromocriptine suppressed endogenous Prl release and did not affect LH secretion...
  44. ncbi Prolactin and rapid eye movement sleep regulation
    R Roky
    Department of Physiology and Biophysics, University of Tennessee, Memphis 38163, USA
    Sleep 18:536-42. 1995
    During the past few years data have accumulated suggesting the involvement of prolactin (PRL) in rapid eye movement sleep (REMS) regulation. Pituitary PRL secretion seems to be, at least in part, sleep-dependent...
  45. ncbi Endocrine parameters of human follicular fluid and fertilization capacity of oocytes
    C Lindner
    , , Germany
    Horm Metab Res 20:243-6. 1988
    ..for additional parameters of oocyte quality, FSH, hCG, estradiol (E2), progesterone (P), testosterone (T), prolactin (PRL) and cAMP were analysed in human follicular fluid (FF) containing a morphologically mature oocyte...
  46. ncbi Sequence of prolactin effects on phospholipid synthesis in Nb2 node lymphoma cells
    J A Rillema
    Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan
    Horm Metab Res 23:218-25. 1991
    In Nb2 node rat lymphoma cells, the effects of prolactin (PRL) on the rates of incorporation of several precursors into neutral lipids, phospholipids and proteins were determined...
  47. ncbi Adrenal androgen secretion and dopaminergic activity in anorexia nervosa
    J Devesa
    , Dept. of Physiology, Faculty of Medicine, Santiago de Compostela, Spain
    Horm Metab Res 20:57-60. 1988
    ..AN patients showed lower baseline DHEA-sulphate (DHEA-S), androstenedione (Adione) and prolactin (PRL) levels than controls...
  48. ncbi Ondansetron does not stimulate prolactin release in breast cancer patients
    P Lissoni
    Divisione di Radioterapia Oncologia, Ospedale San Gerardo, Monza, Milano, Italy
    Tumori 80:209-11. 1994
    AIMS AND BACKGROUND: Prolactin (PRL) may be a tumor growth factor, mainly for breast cancer...
  49. ncbi Neuroendocrine data in chronic post-traumatic headache
    F Savoldi
    Department of Neurology, Headache Center, University of Pavia, Pavia, Italy
    Headache 22:38-45. 1982
    ..v.) and regular insulin (.1 U/kg, i.v.). The responses of gonadotropins, TSH, somatotropin (STH) and prolactin (PRL) were studied in the group as a whole and in clinical subgroups...
  50. ncbi Saponin effects of prolactin-like stimulation of ornithine decarboxylase activity in mouse mammary gland explants
    P B Koduri
    Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan
    Horm Metab Res 24:562-4. 1992
    Saponin, a naturally occurring plant glycoside, was found to elicit a prolactin-like stimulation of ornithine decarboxylase (ODC) activity in mouse mammary gland explants...
  51. ncbi Effect of calcitonin on the prolactin surge of proestrus
    M Cressent
    , Laboratoire de Biophysique, Paris, France
    Horm Metab Res 19:364-6. 1987
    The effect of calcitonin (CT) on the prolactin (PRL) surge of proestrus in rats was investigated under normal and perturbed lighting conditions. Salmon calcitonin (SCT) was injected i.p...
  52. ncbi Growth hormone and prolactin variants in normal subjects. Relative proportions in morning and afternoon samples
    M D Warner
    Department of Psychiatry, Baylor Medical School, Houston, Texas
    Horm Metab Res 25:425-9. 1993
    There are multiple molecular forms of both growth hormone (GH) and prolactin (PRL). Traditionally the two hormones have been measured by radioimmunoassay (RIA) techniques...
  53. ncbi Temporal relationship between prolactin secretion and slow-wave electroencephalic activity during sleep
    K Spiegel
    Laboratoire de Physiologie et de Psychologie Environmentales, CNRS, Strasbourg, France
    Sleep 18:543-8. 1995
    It is well established that plasma prolactin (PRL) concentrations exhibit a sleep-dependent pattern, with the highest levels occurring during sleep and the lowest during waking...
  54. ncbi Episodic thyrotropin (TSH) and prolactin (PRL) secretion during aging in postmenopausal women
    W G Rossmanith
    Frauenklinik, , Germany
    Horm Metab Res 24:185-90. 1992
    ..TSH) secretion in men, no detailed information is available as to age-related alterations in the TSH and prolactin (PRL) release patterns in postmenopausal women (PMW)...
  55. ncbi Concentrations of glycosylated prolactin in the pituitary gland and plasma of lean and obese barrows
    Y N Sinha
    Whittier Institute for Diabetes and Endocrinology, Scripps Memorial Hospital, La Jolla, California
    Horm Metab Res 21:652-7. 1989
    ..The pituitary data suggest that the state of PRL secretion is altered in obese barrows, and that the alteration is more pronounced for G-PRL than for the non-glycosylated counterpart...
  56. ncbi Dissociated response of thyrotropin and prolactin to dopamine receptor blockade with domperidone in hypothyroid subjects
    J A Marcondes
    Endocrine Division, Hospital das Clinicas, Sao Paulo, Brazil
    Horm Metab Res 23:605-8. 1991
    ..These results suggest that the hypothalamic dopamine activity is not altered in primary hypothyroidism and favor the small relevance of dopamine on the control of TSH secretion...
  57. ncbi Clinical efficacy of the aromatase inhibitor anastrozole in relation to prolactin secretion in heavily pretreated metastatic breast cancer
    S Barni
    Division of Oncological Radiotherapy, Ospedale S. Gerardo, Monza (Milan, Italy
    Tumori 84:45-7. 1998
    ..Moreover, it is known that estrogens may stimulate the release of prolactin (PRL), which is a growth factor for breast cancer...
  58. ncbi Prolactin stimulation of protein kinase C in isolated mouse mammary gland nuclei
    G Fan
    Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan
    Horm Metab Res 25:564-8. 1993
    b>Prolactin (PRL) was found to stimulate protein kinase C (PKC) activity in a transient fashion in isolated nuclei derived from the mammary glands of 12-14 day pregnant mice...
  59. ncbi The role of estrogen in the TSH and prolactin responses to thyrotropin-releasing hormone in postmenopausal as compared to premenopausal women
    E M Erfurth
    Department of Internal Medicine of Lund, University Hospital, Sweden
    Horm Metab Res 24:528-31. 1992
    The basal and TRH (Thyrotropin-Releasing Hormone) stimulated TSH (Thyrotropin) and PRL (Prolactin) responses (incremental area; IA) to 200 micrograms TRH was studied in 13 pre- and 13 postmenopausal women of 60 years of age...
  60. ncbi Serum prolactin concentrations and epilepsy. A study which compares healthy subjects with a group of patients in presurgical evaluation and circadian variations with those related to seizures
    J Bauer
    Department of Neurology, , Federal Republic of Germany
    Eur Arch Psychiatry Clin Neurosci 241:365-71. 1992
    ..undergoing presurgical epilepsy evaluation with intracranial EEG electrodes, circadian variations of serum prolactin (PRL) were measured...
  61. ncbi Serum prolactin and growth hormone determined by radioimmunoassay and a two-site immunoradiometric assay: comparison with the Nb2 cell bioassay
    D P Rose
    Division of Nutrition and Endocrinology, Naylor Dana Institute for Disease Prevention, Valhalla, New York
    Horm Metab Res 20:49-53. 1988
    Serum levels of the two lactogenic hormones prolactin (PRL) and growth hormone (GH) were compared when determined by radioimmunoassay (RIA) and two-site immunoradiometric (IRMA) assays in 83 normal premenopausal women...
  62. ncbi Growth hormone and prolactin secretion after metoclopramide administration (DA2 receptor blockade) in fertile women
    J S Cunha-Filho
    Obstetrics and Gynecology Department, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil
    Horm Metab Res 33:536-9. 2001
    ..All patients presented normal serum levels of estradiol, prolactin, insulin, fasting glucose and IGF-I. Serum GH levels were not changed after metoclopramide infusion (p = 0...
  63. ncbi beta-Mercaptoethanol differentially acts on the rat somatotrophs and lactotrophs in primary culture to suppress the secretion of immunoreactive hormones
    K Nakamura
    Second Department of Physiology, School of Medicine, Iwate Medical University, Japan
    Horm Metab Res 26:565-9. 1994
    We previously reported that beta-mercaptoethanol (ME) reduced the content of immunoreactive prolactin (iPRL) within the adenohypophyseal cells, primarily through its direct effect on the disulfide bonding of the PRL molecule...
  64. ncbi Thyroidectomy blocks stress-induced prolactin rise in rats: role of the central serotonergic system
    M J Ramalho
    Departamento de Fisiologia, Universidade Federal da Bahia, Salvador, Brazil
    Horm Metab Res 24:462-5. 1992
    ..Thyroidectomy partially blocks stress-induced prolactin (PRL) secretion. Previous administration of MK 212, a serotonin agonist, reverts this picture...
  65. ncbi Long-term effect of prolactin treatment on glucose-induced insulin secretion in cultured neonatal rat islets
    S C Crepaldi
    , Universidade Estadual Paulista (UNESP, Bauru/Rio Claro, SP, Brazil
    Horm Metab Res 29:220-4. 1997
    ..efflux were studied in neonatal rat islets maintained in culture for 7 or 19 days in the absence or presence of prolactin (PRL)...
  66. ncbi Different glycosylation of human prolactin in cystic fibrosis patients
    M T Robertson
    Department of Pediatrics, Georgetown University, Washington
    Acta Univ Carol Med (Praha) 36:49-54. 1990
    ..grafts unlike that from normal skin did not increase when the host mice were injected with antibodies to human prolactin (hPRL). 3. One explanation for the above observations postulated a structurally modified PRL in CF patients...
  67. ncbi Prolactin secretion and sleep
    K Spiegel
    Laboratoire de Physiologie et de Psychologie Environnementales, CNRS/INRS, Strasbourg, France
    Sleep 17:20-7. 1994
    To clarify the relationship between prolactin (PRL) secretion and sleep, three experimental procedures were employed and secretory rates were estimated from plasma levels using a deconvolution procedure...
  68. ncbi An immunocytochemical study of pituitary adenomas and focal hyperplasia in old Sprague-Dawley and Fischer 344 rats
    G E Sandusky
    Pathology Department, Lilly Research Laboratories, Division of Eli Lilly and Company, Greenfield, Indiana 46140
    Toxicol Pathol 16:376-80. 1988
    ..The SD strain had a total of 75 tumors with 10% in males and 65% in females. Tumors immunoreactive for prolactin (PRL) alone were the most common tumor (64%) with the immunonegative tumor being the second most common (17.3%)...
  69. ncbi Pharmacological activation of the GABAergic system does not affect GH and PRL release in acromegaly
    F Orio
    Department of Endocrinology, General Hospital of Eboli, Salerno, Italy
    Horm Metab Res 20:701-4. 1988
    ..Since GABA has been shown to modulate growth hormone (GH) and prolactin (PRL) secretion in human subjects, it seemed reasonable to investigate hypothalamic GABAergic functioning ..
  70. ncbi Neuroendocrine evaluation in Kleine-Levin syndrome: evidence of reduced dopaminergic tone during periods of hypersomnolence
    A L Chesson
    Neurology, Service, Louisiana State University Medical Center, Shreveport 71130-3932
    Sleep 14:226-32. 1991
    ..Blood samples were obtained every 20 min and assayed for thyroid-stimulating hormone (TSH), cortisol (CORT), prolactin (PRL) and growth hormone (GH)...
  71. ncbi Differences in growth hormone and prolactin secretion associated with environmental temperature and energy intake
    M J Dauncey
    AFRC Institute of Animal Physiology and Genetics Research, Cambridge, United Kingdom
    Horm Metab Res 22:524-7. 1990
    ..of environmental temperature and level of energy intake on plasma concentrations of growth hormone (GH) and prolactin (PRL) have been investigated in 14 week old pigs acclimated to 35 or 10 degrees C on a high (H) or low (L) ..
  72. ncbi Direct suppression by beta-mercaptoethanol of the prolactin immunoreactivity within the cultured rat adenohypophyseal cells
    K Nakamura
    Second Department of Physiology, School of Medicine, Iwate Medical University, Japan
    Horm Metab Res 25:603-7. 1993
    Effects of beta-mercaptoethanol (ME) on the hormonal dynamics of immunoreactive prolactin (iPRL) were examined, using rat adenohypophyseal cells in primary culture...
  73. ncbi Salt sensitivity and central dopaminergic activity in patients with essential hypertension
    S Hamasaki
    Department of Internal Medicine III, Kumamoto University Medical School, Japan
    Am J Hypertens 4:745-51. 1991
    ..The change of central dopaminergic activity by salt load was evaluated as the percentage change of plasma prolactin (PRL) response to a small dose (25 micrograms) of thyrotropin-releasing hormone (TRH) administered intravenously...
  74. ncbi Ultrastructural localization of prolactin-like antigenic determinants in neurosecretory cells in the brain of the honeybee (Apis mellifica)
    K P Schmid
    , Abteilung Innere Medizin I, , Germany
    Horm Metab Res 22:413-7. 1990
    With two different antisera to human prolactin (hPRL), the ultrastructural localization of PRL-like material in the bee brain is examined by means of the protein-A-gold method at the electron microscopical level...
  75. ncbi REM sleep in humans begins during decreased secretory activity of the anterior pituitary
    M Follenius
    Laboratoire de Physiologie et de Psychologie Environnementales, Strasbourg, France
    Sleep 11:546-55. 1988
    ..Plasma levels of prolactin (PRL), adrenocorticotropic hormone (ACTH), luteotropin (LH), thyroid-stimulating hormone (TSH) and growth ..
  76. ncbi Incidence and characteristics of microprolactinomas (3-5 mm) in 4199 women assayed for prolactin
    M L Batrinos
    Department of Pharmacology, University of Athens Medical School, Goudi, Greece
    Horm Metab Res 24:384-91. 1992
    ..In the present study serum prolactin (PRL) was assayed in 4199 women aged 14-43 years belonging to 4 groups: A: 753 women with normal cycles (NC) and ..
  77. ncbi Reduced prolactin release during immobilization stress in thyrotoxic rats: role of the central serotoninergic system
    M J Ramalho
    Departamento de Fisiologia, Universidade Federal da Bahia, Salvador
    Horm Metab Res 27:121-5. 1995
    ..p. for 7 days) as well as their euthyroid controls were submitted to immobilization stress during forty minutes. Prolactin (PRL) secretion during stress was significantly lower in T4 increases rats as compared to control animals...
  78. ncbi Zinc: an inhibitor of prolactin (PRL) secretion in humans
    J Brandao Neto
    Department of Internal Medicine, Universidade Estadual Paulista UNESP, Botucatu, Sao Paulo, Brazil
    Horm Metab Res 21:203-6. 1989
    The response of plasma prolactin (PRL) to oral administration of increasing doses of zinc (25.0, 37.5 and 50.0 mg) was studied in 17 normal adult men and women...
  79. ncbi Possible thyrotrophs insensitivity to dopamine in hyperprolactinaemic amenorrhoeic patients
    A Nyboe Andersen
    Department of Gynaecology and Obstetrics, Frederiksberg Hospital, Copenhagen, Denmark
    Horm Metab Res 21:328-30. 1989
    ..9% of basal levels). DA infusion caused a significant reduction in serum prolactin (PRL) levels both in hyperprolactinaemic patients (P less than 0.001) and normal women (P less than 0...
  80. ncbi Dexamethasone suppresses the release of prolactin from the rat anterior pituitary gland by lipocortin 1 dependent and independent mechanisms
    A D Taylor
    Department of Pharmacology, Charing Cross and Westminster Medical School, London, UK
    Neuroendocrinology 62:530-42. 1995
    Glucocorticoids have been shown repeatedly to inhibit the release of prolactin (PRL) in the rat but their site and mode of action is unknown...
  81. ncbi [A review of the effects of prolactin hormone and cytokine on the development and pathogenesis of autoimmune diseases]
    M Fojtikova
    Revmatologický ústav Praha
    Vnitr Lek 56:402-13. 2010
    b>Prolactin (PRL) is not only a pituitary hormone with important role in the reproduction but it also acts as a cytokine involved in the immune response...
  82. ncbi Maternal exposure to atrazine during lactation suppresses suckling-induced prolactin release and results in prostatitis in the adult offspring
    T E Stoker
    Endocrinology Branch, Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Toxicol Sci 52:68-79. 1999
    The availability of prolactin (PRL) to the neonatal brain is known to affect the development of the tuberoinfundibular (TIDA) neurons and, as a consequence, lead to alterations in subsequent PRL regulation...
  83. ncbi Internalization of prolactin receptor and prolactin in transfected cells does not involve nuclear translocation
    M Perrot Applanat
    INSERM U 344, , Paris, France
    J Cell Sci 110:1123-32. 1997
    b>Prolactin (PRL) interacts with a specific, well characterized plasma membrane receptor (PRLR) that is coupled to signal transduction pathways involving Jak2, Fyn, and MAP kinases, and signal transducers and activators of transcription (..
  84. doi Effects of salinity and endocrine-disrupting chemicals on expression of prolactin and prolactin receptor genes in the euryhaline hermaphroditic fish, Kryptolebias marmoratus
    Jae Sung Rhee
    Department of Molecular and Environmental Bioscience, Graduate School, Hanyang University, Seoul 133 791, South Korea
    Comp Biochem Physiol C Toxicol Pharmacol 152:413-23. 2010
    b>Prolactin plays an essential role in ion uptake as well as reduction in ion and water permeability of osmoregulatory surfaces in euryhaline fish. Kryptolebias marmoratus is a euryhaline fish with unique internal self-fertilization...
  85. ncbi Anti-prolactin autoantibodies in pregnant women with systemic lupus erythematosus: maternal and fetal outcome
    A Leaños-Miranda
    Research Unit in Reproductive Medicine, Hospital de Ginecologia y Obstetricia Luis Castelazo Ayala, Instituto Mexicano del Seguro Social, Mexico, DF, Mexico
    Lupus 16:342-9. 2007
    ..of this study was to determine in pregnant women with systemic lupus erythematosus (SLE) the frequency of anti-prolactin autoantibodies and to compare the outcome of pregnancy in SLE women with and without anti-prolactin ..
  86. ncbi Prolactin in the brushtail possum (Trichosurus vulpecula): development of homologous radioimmunoassay using recombinant possum prolactin
    J L Crawford
    Reproduction Group, AgResearch Ltd, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    Gen Comp Endocrinol 142:297-307. 2005
    We report the production of recombinant possum prolactin (posPrl), and its use in the development and validation of a highly specific homologous radioimmunoassay for the measurement of prolactin (Prl) in brushtail possums...
  87. ncbi Expression of prolactin-releasing peptide and prolactin in the euryhaline mudskippers (Periophthalmus modestus): prolactin-releasing peptide as a primary regulator of prolactin
    T Sakamoto
    Ushimado Marine Laboratory, Faculty of Science, Okayama University, Ushimado, Setouchi 701 4303, Japan
    J Mol Endocrinol 34:825-34. 2005
    b>Prolactin (PRL)-releasing peptide (PrRP) is a strong candidate stimulator of pituitary PRL transcription and secretion in teleosts. However, the role in control of extrapituitary PRL expression is unclear even in mammals...
  88. ncbi Cross-reactivities of macroprolactin and big-prolactin in three commercial immunoassays for prolactin: a chromatographic analysis
    M Jane Ellis
    Endolab, 21 St Asaph St, Christchurch Hospital, Private Bag 4710, Christchurch, New Zealand
    Clin Biochem 40:1285-90. 2007
    To compare the recently released Elecsys Prolactin II with the Access and Centaur assays for reactivity with macroPRL, bigPRL and monomeric PRL in samples fractionated using gel filtration chromatography (GFC).
  89. ncbi Steady-state sodium absorption and chloride secretion of colon and coprodeum, and plasma levels of osmoregulatory hormones in hens in relation to sodium intake
    S S Arnason
    Department of Physiology, University of Iceland,
    J Comp Physiol B 161:1-14. 1991
    ..abstract truncated at 400 words)..
  90. ncbi Catecholamines and pituitary function. VII: Effects of acute and chronic dopamine-receptor blockade on pituitary response to TRH-GNRH in normal women and in patients with hyperprolactinemic amenorrhea
    C Giammartino
    Istituto di Clinica Medica 1, , Italy
    Horm Metab Res 20:44-8. 1988
    ....
  91. ncbi Expression of an orphan nuclear receptor DAX-1 in human pituitary adenomas
    S Ikuyama
    Third Department of Internal Medicine, Kyushu University Faculty of Medicine, Fukuoka, Japan
    Clin Endocrinol (Oxf) 48:647-54. 1998
    ..CONCLUSIONS: The results shown here indicate that DAX-1 is expressed in the majority of human pituitary adenomas of gonadotrophic origin in parallel with Adrenal-4-binding protein/steroidogenic factor-1...
  92. ncbi Prolactin and autoimmunity
    Annamaria De Bellis
    Department of Clinical and Experimental Medicine and Surgery F Magrassi, A Lanzara, Second University of Naples, via Pansini N 5, 80131, Napoli, Italy
    Pituitary 8:25-30. 2005
    The interrelationship between prolactin (PRL) and the immune system have been elucitaded in the last decade, opening new important horizons in the field of the immunoendocrinology...
  93. ncbi Effect of prolactin on the expression of luteinizing hormone receptors during cell differentiation in cultured rat granulosa cells
    T Hirakawa
    Department of Obstetrics and Gynecology School of Medicine, Gunma University, Maebashi, Japan
    Endocrinology 140:3444-51. 1999
    ..Therefore, it may be possible that PRL acts to stimulate labile LH receptor mRNA-destabilizing factors...
  94. doi Prolactin and insulin ultradian secretion and adipose tissue lipoprotein lipase expression in severely obese women after bariatric surgery
    Geltrude Mingrone
    Department of Internal Medicine, Universita Cattolica S Cuore, Rome, Italy
    Obesity (Silver Spring) 16:1831-7. 2008
    Hyperprolactinemia is associated with obesity. Furthermore, in human adipose tissue cultured in vitro, prolactin (PRL) inhibited lipoprotein lipase (LPL) activity via functional PRL receptors.
  95. ncbi Molecular characterization of the prolactin receptor in two fish species, tilapia Oreochromis niloticus and rainbow trout, Oncorhynchus mykiss: a comparative approach
    P Prunet
    INRA SCRIBE, Group in Physiology of Adaptation and Stress, Rennes, France
    Can J Physiol Pharmacol 78:1086-96. 2000
    We present recent information on the molecular characterization of the prolactin receptor (PRL-R) in two teleost species, tilapia (Oreochromis niloticus) and rainbow trout (Oncorhynchus mykiss), in the perspective of improved ..
  96. ncbi The human prolactin receptor in the fetal membranes, decidua, and placenta
    R A Maaskant
    Pacific Biomedical Research Center, University of Hawaii, Honolulu 96822, USA
    J Clin Endocrinol Metab 81:396-405. 1996
    ..Its increased expression during labor and delivery in the chorion, decidua, and placenta supports an autocrine/paracrine role for decidual PRL in the peripartum...
  97. ncbi Characterization and applications of monoclonal antibodies to the prolactin receptor
    H Okamura
    Laboratory of Molecular Endocrinology, McGill University, Royal Victoria Hospital, Montreal, Quebec, Canada
    Endocrinology 124:2499-508. 1989
    ..Microsomal PRL receptors from rat ovary, prostate, and Nb2 cells and purified receptors from pig and rabbit mammary gland were subjected to immunoblot analysis.(ABSTRACT TRUNCATED AT 400 WORDS)..
  98. ncbi The different forms of the prolactin receptor in the rat corpus luteum: developmental expression and hormonal regulation in pregnancy
    C M Telleria
    Department of Physiology and Biophysics, College of Medicine, University of Illinois, Chicago 60612, USA
    Endocrinology 138:4812-20. 1997
    ....
  99. ncbi Detection of prolactin receptor gene expression in the sheep pituitary gland and visualization of the specific translation of the signal in gonadotrophs
    D J Tortonese
    Medical Research Council Reproductive Biology Unit, Centre for Reproductive Biology, Edinburgh, Scotland, United Kingdom
    Endocrinology 139:5215-23. 1998
    ....
  100. ncbi Quantitation of prolactin receptor mRNA in the maternal rat brain during pregnancy and lactation
    R A Augustine
    Department of Anatomy and Structural Biology, School of Medical Sciences, University of Otago, PO Box 913, Dunedin, New Zealand
    J Mol Endocrinol 31:221-32. 2003
    b>Prolactin receptor (PRL-R) expression in the brain is increased in lactating rats compared with non-pregnant animals...
  101. ncbi Hormone secretion in vitro by plurihormonal pituitary adenomas of the acidophil cell line
    S L Asa
    Department of Pathology, St Michael s Hospital, Toronto, Ontario, Canada
    J Clin Endocrinol Metab 75:68-75. 1992
    ..Our data strengthen the view that these three plurihormonal adenomas of the acidophil cell line are not only morphologically but also functionally different and warrant separation...

Research Grants64

  1. Prolactin as a Growth Factor in Breast Cancer
    Nira Ben-Jonathan; Fiscal Year: 2013
    ..We present evidence that prolactin (PRL) serves as a survival factor which antagonizes the cytotoxicity of the DNA-damaging agents cisplatin and ..
  2. Tyrosine Phosphyorylation and Growth Hormone Signaling
    STUART FRANK; Fiscal Year: 2005
    Growth hormone (GH) and prolactin (PRL) interact with GH and prolactin receptors (GHR; PRLR), both cytokine receptors, causing activation of the GHR- and PRLR-associated tyrosine kinase, JAK2, and the STATS and ERK pathways...
  3. Maria Diakonova; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): In normal mammary development, the hormone prolactin (PRL) is critical for alveolar proliferation and differentiation...
  4. SUZANNE MARIE SCHAUWECKER; Fiscal Year: 2015
    ..The peptide hormone prolactin (PRL) promotes normal breast tissue growth and maturation, but PRL also contributes to breast cancer development...
  5. Stability of prolactin receptor and prolactin signaling
    Serge Y Fuchs; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Pituitary hormone prolactin (PRL), which promotes growth and survival of mammary epithelial cells and plays a key role in breast tumorigenesis, acts through PRL receptor (PRLr)...
  6. ENDOCRINE REGULATION OF MATERNAL BEHAVIOR
    Robert Bridges; Fiscal Year: 2009
    ..The first series of studies will examine the role of the neural prolactin (PRL) receptor in the initiation of maternal behavior...
  7. CRAIG BARCUS; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Prolactin (PRL) involvement in breast cancer progression is increasingly recognized, yet its actions are poorly understood...
  8. Experimental Modeling of Human Breast Cancer in Mice
    Hallgeir Rui; Fiscal Year: 2012
    ..Novel and independent insight from the two collaborating laboratories suggest that prolactin acts as a modulator of drug sensitivity in human breast cancer...
  9. Christin Carter-Su; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The "Growth hormone (GH) and prolactin (PRL) family" defines a protein family that includes several members, including GH, PRL, placental lactogens (PLs) and various proteolytic fragments called ..
  10. Effects of Chronic Estrogen on TIDA Neurons: Role of Cytokines and NO
    Puliyur S MohanKumar; Fiscal Year: 2010
    ..Dopamine (DA) released from TIDA neurons inhibits prolactin (PRL) secretion from the anterior pituitary...
  11. Role and Mechanisms of Prolactin on HPA Axis Activation Following Stress
    James Janik; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The major hypothesis to be tested is that circulating prolactin (PRL) levels regulate the Hypothalamic- Pituitary-Adrenal (HPA) axis response to stress...
  12. Role of the serine-threonine kinase PAK1 in prolactin-dependent signaling
    Maria Diakonova; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): In normal mammary development, the hormone prolactin (PRL) is critical for alveolar proliferation and differentiation...
  13. PITUITARY-SPECIFIC ONCOGENE SIGNALING MECHANISMS
    Arthur Gutierrez Hartmann; Fiscal Year: 2009
    ..and this composite site were shown to be required not only for the oncogenic V12Ras response of the rat (r) prolactin (PRL) promoter, but also to reconstitute lactotropespecific rPRL promoter activity in HeLa nonpituitary cells...
  14. JOEL TABAK-SZNAJDER; Fiscal Year: 2014
    The Central Hypothesis of this renewal application is that under physiological conditions, prolactin (PRL) secretion is inhibited by dopamine (DA) and stimulated by oxytocin (OT) and that the activities of these neurons are regulated by ..
  15. SPECIFIC REPRESSION OF PROLACTIN GENE EXPRESSION
    Richard N Day; Fiscal Year: 2012
    ..The expression of the prolactin (PRL) gene in anterior pituitary lactotrope cells is a proven model system to define the molecular mechanisms ..
  16. Multimeric Signaling Complexes in PRLr Transduction
    Charles V Clevenger; Fiscal Year: 2013
    The actions of prolactin (PRL), a hormone utilized in normal and malignant mammary tissues, are mediated through its receptor, the PRLr. PRL acts to stimulate the growth, motility, and progression of human breast cancer...
  17. Linda A Schuler; Fiscal Year: 2015
    ..Multiple studies point to a close link between prolactin (PRL), aand the pathogenesis and therapeutic responsiveness of ER?+ breast cancer...
  18. Signaling Mechanisms Regulating Pituitary Gene Expression
    Dawn L Duval; Fiscal Year: 2010
    ..of threonine 220, T220D and T220E, reduced the ability of Pit-1 to target Ras and estradiol stimulation to the prolactin promoter...
  19. Prolactin as a lacrimal gland immunomodulator
    Joel Schechter; Fiscal Year: 2009
    ..investigators'interdisciplinary team recently found that elevated estradiol (E2), progesterone (PRG) and prolactin (PRL) induce profound cellular physiological- and immunoarchitectural transformations;E2 and PRG alter the ..
  20. Interactions of PRL, Estrogen, and TFFa in Mammary Cancer
    Lisa M Arendt; Fiscal Year: 2010
    ..Dr. Linda Schuler, a recognized leader in the field of prolactin signaling, will mentor the principal investigator's scientific development...
  21. SECRETION OF PROLACTIN--REGULATION BY ENDOTHELIN
    MARC FREEMAN; Fiscal Year: 2004
    ..The aims of this proposal revolve around elucidation of the mechanisms whereby ETs' affect pituitary prolactin (PRL) secretion...
  22. Prolactin as a risk biomarker of ovarian cancer
    Anna Lokshin; Fiscal Year: 2009
    ..No protein biomarker for ovarian cancer risk has yet been identified. We have demonstrated that prolactin (PRL), a multifunctional hormone/cytokine, is elevated in blood of over 60% of healthy women with a strong ..
  23. IRF 1 AND PROLACTIN IN T CELL ACTIVATION
    Li Yuan Yu Lee; Fiscal Year: 1999
    The peptide hormone prolactin (PRL) exerts a profound effect on both cellular proliferation and differentiation in a variety of tissues, but its role as an immunomodulator has not been well-defined...
  24. GORDON RESEARCH CONFERENCE ON PROLACTIN
    LI YUAN YU LE; Fiscal Year: 2000
    The 2000 Gordon Research Conference on Prolactin will provide an outstanding forum for presentation and thorough critical discussion of progress in scientific areas directly pertinent to the functional, biochemical and molecular genetic ..
  25. ROLE OF G PROTEINS IN PROLACTIN SIGNAL TRANSDUCTION
    Jennifer Larsen; Fiscal Year: 1993
    Hyperprolactinemia is an important cause of hypogonadism and infertility in men and women. Prolactin (PRL) receptors have been identified in many tissues, but how PRL causes these clinical effects and others are not well understood ..
  26. PITUITARY TUMORS--PATHOGENESIS AND CELLULAR FUNCTION
    THOMAS CROXTON; Fiscal Year: 1993
    Excess secretion of prolactin (PRL) a common cause of female infertility, is usually associated with an anterior pituitary prolactinoma...
  27. PURIFICATION AND PHYSIOLOGIC ROLE OF A LIVER LACTOGEN
    L Frawley; Fiscal Year: 1990
    ..This material stimulates casein release in the absence of added prolactin (PRL) and is actually more potent than PRL in this regard...
  28. EXERCISE AS A MEANS OF ENHANCING IMMUNITY IN THE AGED
    Jeffrey Woods; Fiscal Year: 2001
    ....
  29. NEURAL AND HORMONAL REGULATION OF LACTATION
    CLARK GROSVENOR; Fiscal Year: 1993
    ....
  30. Stephen H White; Fiscal Year: 2016
    ..Our goal is to tighten the connection between the physical and biological principles as a basis for prediction algorithms. ..
  31. Targeting PRL Phosphatases for Cancer Therapy
    Zhong Yin Zhang; Fiscal Year: 2012
    ..Obtaining this knowledge is vital for understanding the PRL3-mediated tumor growth and metastasis, and for the development of novel anti-cancer therapies targeted to PRL3. ..
  32. RECONSTITUTION OF PITUITARY SPECIFIC TRANSCRIPTION
    Arthur Gutierrez Hartmann; Fiscal Year: 2010
    ..abstract_text> ..
  33. Development & Validation of Instrumented Synthetic Mechanical Analog Lumbar Spine
    JOHN ERIC JAMES; Fiscal Year: 2010
    ..The models will aid in understanding the effects of surgical procedures and implants on potential patient outcomes. An analogue spine model will also be an efficient way to perform biomechanical tests and product development. ..
  34. Elizabeth J Glover; Fiscal Year: 2015
    ....
  35. The Role of Phosphatase of Regenerating Liver-3 in Alcohol-Associated Disease
    Mark W Zimmerman; Fiscal Year: 2012
    ....
  36. PITUITARY KALLIKREIN & PROHORMONE PROCESSING
    CLAUD POWERS; Fiscal Year: 1992
    ..expression and physiological regulation closely paralleling MSH and beta-endorphin in the intermediate lobe, and prolactin (PRL) in the anterior pituitary lobe (AP)...
  37. SUSANA T CHUNG; Fiscal Year: 2016
    ..The long-term goals of this project are to understand how the "new fovea" develops, and to understand the limiting factors and the potential for improving vision for people with macular disorders. ..
  38. Gordon E Legge; Fiscal Year: 2016
    ..A major goal of the current proposal is to develop principled training methods to enhance low-vision reading, particularly for people with macular degeneration. ..
  39. HYPOTHALAMIC CONTROL OF PROLACTIN SECRETION
    JAMES VOOGT; Fiscal Year: 2001
    ..being investigated in this proposal is that mating exposes a neuronal clock that results in twice-daily prolactin (PRL) surges necessary for maintenance of pregnancy...
  40. FGF SIGNALING AND PITUITARY TUMORIGENESIS
    ANDREW BRADFORD; Fiscal Year: 2001
    ..Bradford demonstrated a role for FGF in regulation of the prolactin (PRL) promoter in GH4 pituitary cells...
  41. FUNCTION OF A GROWTH INDUCED GENE IN LIVER REGENERATION
    KLAUS KAESTNER; Fiscal Year: 2003
    ....
  42. FUNCTION OF THE DECIDUAL TISSUE
    Geula Gibori; Fiscal Year: 2007
    ..Gene knockout strategies have revealed a crucial role for prolactin (PRL), Interleukin-11 (IL-11) and for decidual steroidogenic enzymes, 5alpha-reductase type 1 (5alphaR1) and 20a-..
  43. Neural Changes Induced by Mating in the Female
    MARY ERSKINE; Fiscal Year: 2007
    ..to initiate the endocrine changes of early pregnancy, in particular, the twice-daily surges of pituitary prolactin (PRL) secretion which occur for the first 10-12 days of pregnancy or pseudopregnancy (PSP) and which maintain ..
  44. ANGIOSTATIC FUNCTION OF HUMAN 16K PROLACTIN
    Nira Ben Jonathan; Fiscal Year: 2000
    ..b>Prolactin (PRL) is a 23 kDa pituitary hormone whose main target is the breast...
  45. IMMUNOREGULATORY ROLES OF LYMPHOCYTE-DERIVED PROLACTINS
    David Montgomery; Fiscal Year: 1992
    b>Prolactin (PRL) is an anterior pituitary hormone recently found to be a physiologic regulator of immune responses...
  46. PROLACTIN-CYCLOSPORINE INTERACTIONS IN GROWTH REGULATION
    NANCY ZORN; Fiscal Year: 1990
    b>Prolactin (PRL), a pituitary polypeptide hormone, has pronounced physiological effects on normal and neoplastic growth and on differentiation...
  47. ENDOCRINE REGULATION OF MATERNAL BEHAVIOR
    Robert Bridges; Fiscal Year: 2000
    ..We recently demonstrated a central site of action for the lactogenic hormones, prolactin (PRL) and rat placental lactogens (rPLs), in the induction of maternal behavior in female rats...
  48. PTPases as Therapeutic Targets
    Taolin Yi; Fiscal Year: 2005
    ....
  49. FUNCTIONAL SIGNIFICANCE OF 16K PROLACTIN
    CHARLES NICOLL; Fiscal Year: 1990
    b>Prolactin (PRL) stimulates the growth and function of target tissues such as the mammary gland (MG) and the prostate and may contribute to the development of breast and prostate cancer...
  50. STATHMIN AND P11 MEDIATE ACTIONS OF NGF AND PROLACTIN
    David Prentice; Fiscal Year: 1992
    DESCRIPTION (Adapted from applicants abstract): Nerve growth factor (NGF) and prolactin (PRL) exert actions within numerous tissues in the body, stimulating metabolism as well as growth and differentiation...
  51. Delineating the function of PRL-1 in Drosophila.
    LESLIE SAUCEDO; Fiscal Year: 2009
    ..Thorough characterization of PRLs is paramount to understanding under what circumstances PRLs can contribute to cancers and is also necessary to assess whether targeting PRLs in cancers may harm healthy tissues as well. ..
  52. IMMUNOREACTIVE BRAIN PROLACTIN
    WILLIAM DEVITO; Fiscal Year: 1993
    In the mammalian brain, like the pituitary, three immunoreactive prolactin (IR-PRL) like proteins have been identified with molecular weights of 24, 16, and 8K...
  53. Mahnaz Shahidi; Fiscal Year: 2015
    ..The findings from the proposed research will benefit our veterans and all aging people. ..
  54. Neuroendocrine Hormones to Promote Immune Reconstitution
    William Murphy; Fiscal Year: 2007
    ..Neuroendocrine hormones such as growth hormone (GH) and prolactin (PRL) have been demonstrated to exert pleiotropic effects on the immune system...
  55. PROLACTIN AND ENDOTHELIAL WOUND REPAIR IN VITRO
    CARRIE MERKLE; Fiscal Year: 2001
    ..The significance and effects of stress-induced prolactin (Prl) elevation remain largely unknown, despite many reports showing that stress increases Prl...
  56. DYNAMICS OF CALCIUM SIGNALING AND PRL GENE EXPRESSION
    FREDRIC BOOCKFOR; Fiscal Year: 2001
    ..free calcium ([Ca2+])i, play an important role in both basal and secretagogue- regulated control of the prolactin (PRL) gene...
  57. FATTY ACID EPOXIDES AS MODULATORS OF PROLACTIN RELEASE
    John Cashman; Fiscal Year: 1991
    ..e. 5,6-epoxyeicosatrienoic, 5,6-EET) is a potent eicosanoid prolactin (PRL)-releasing agent in anterior pituitary (AP) cells, in vitro...
  58. Xenoestrogens: Genomic and Non-genomic Mechanisms
    Nira Ben Jonathan; Fiscal Year: 2006
    ..We previously reported that these compounds induced lactotroph proliferation, increased prolactin (PRL) gene expression and release, altered pituitary ERalpha and ERbeta expression and affected the growth and ..
  59. NEONATAL EFFECTS AND METABOLISM OF XENOESTROGENS
    Nira Ben Jonathan; Fiscal Year: 2003
    ..It is proposed to use the neuroendocrine axis that regulates prolactin (PRL) as a model system for addressing the following questions: a) do xenoestrogens given to early neonatal rats ..
  60. Prolactin and Estrogens as Mitogens in Prostate Cancer
    Nira Ben Jonathan; Fiscal Year: 2002
    DESCRIPTION (Provided by the applicant) Prolactin (PRL) and prolactin receptor (PRLR) are members of cytokine super family. Overproduction of PRL by prostate cells results in prostatic hyperplasia in mice...
  61. PROLACTIN INHIBITION OF APOPTOSIS--MECHANISM OF ACTION
    Arthur Buckley; Fiscal Year: 2001
    ....
  62. Orexinergic Pathways in Central Autonomic Control
    WILLIS SAMSON; Fiscal Year: 2005
    ..abstract_text> ..
  63. PHYSIOLOGY OF THE PROLACTIN RELEASING PEPTIDES
    Willis K Samson; Fiscal Year: 2010
    ..which we have demonstrated to act at least pharmacologically to stimulate stress hormone secretion (prolactin, PRL, and adrenocorticotropin, ACTH) by a brain site of action...
  64. Function of NudC, a Prolactin Regulated Gene
    Li Yuan Yu Lee; Fiscal Year: 2007
    The pituitary hormone prolactin (PRL) stimulates the growth and differentiation of many tissues and cell types...