Genomes and Genes
Gene Symbol: progesterone receptor
Description: progesterone receptor
Alias: NR3C3, progesterone receptor, nuclear receptor subfamily 3 group C member 3
Publications274 found, 100 shown here
- Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and BP Kastner
Laboratoire de Genetique Moleculaire des Eucaryotes, CNRS, Strasbourg, France
EMBO J 9:1603-14. 1990The human progesterone receptor (hPR) cDNA, synthesized from T47D breast cancer cells, and the hPR gene 5'-flanking region were cloned and sequenced...
- Analysis of the human progesterone receptor gene polymorphism progins in Austrian ovarian carcinoma patientsD Tong
Department of Obstetrics and Gynecology, Division of Gynecology, General Hospital of Vienna, University of Vienna, Vienna, Austria
Int J Cancer 95:394-7. 2001..A polymorphism in intron G of the human progesterone receptor (PgR), caused by an Alu insertion, was described to be associated with ovarian carcinoma in a pooled ..
- Distinct functional differences of human progesterone receptors A and B on gene expression and growth regulation in two endometrial carcinoma cell linesEllen Smid-Koopman
Department of Obstetrics and Gynaecology, Erasmus Medical Center, Rotterdam, The Netherlands
J Soc Gynecol Investig 10:49-57. 2003To study the functional differences between the two progesterone receptor isoforms (hPRA and hPRB) in human endometrial cancer, two new endometrial carcinoma cell lines were created-one expressing hPRA and one expressing hPRB...
- The multiple promoter methylation profile of PR gene and ERalpha gene in tumor cell linesZe Jun Liu
Department of Laboratory Medicine, Hamamatsu University School of Medicine, Hamamatsu 431 3192, Japan
Life Sci 73:1963-72. 2003..PCR (MSP) assay method, we observed alterations in DNA methylation at the double promoter regions of the progesterone receptor (PR) gene and estrogen receptor (ERalpha) gene in various tumor cell lines...
- Subnuclear distribution of progesterone receptors A and B in normal and malignant endometriumRebecca L Arnett-Mansfield
Westmead Institute for Cancer Research, University of Sydney at the Westmead Millennium Institute, NSW, Australia
J Clin Endocrinol Metab 89:1429-42. 2004The nuclear progesterone receptor (PR), which is expressed as two proteins with different functions (PRA and PRB), is expressed in the normal endometrium and endometrial cancer...
- Phosphorylation-dependent antagonism of sumoylation derepresses progesterone receptor action in breast cancer cellsAndrea R Daniel
Department of Medicine Division of Hematology, Oncology, and Transplantation, University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
Mol Endocrinol 21:2890-906. 2007..In the context of elevated protein kinase activities, such as during mammary gland development or breast cancer progression, phosphorylated PR-B may be undersumoylated, transcriptionally hyperactive, and unstable/undetectable...
- Promoter hypermethylation of TMS1, BRCA1, ERalpha and PRB in serum and tumor DNA of invasive ductal breast carcinoma patientsSameer Mirza
Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
Life Sci 81:280-7. 2007..This study also underscores the potential utility of DNA methylation based screening of serum (a surrogate for tumor DNA methylation) as a tool for detection of breast cancer...
- Progesterone receptor is a significant factor associated with clinical outcomes and effect of adjuvant tamoxifen therapy in breast cancer patientsShuzhen Liu
Genetic Pathology Evaluation Centre at Vancouver General Hospital, Prostate Center, University of British Columbia, Vancouver, BC, Canada
Breast Cancer Res Treat 119:53-61. 2010..The additional value of progesterone receptor (PR) has remained controversial...
- Protein kinases mediate ligand-independent derepression of sumoylated progesterone receptors in breast cancer cellsAndrea R Daniel
Department of Medicine, Division of Hematology, University of Minnesota Masonic Cancer Center, Minneapolis, MN 55455, USA
Proc Natl Acad Sci U S A 106:14287-92. 2009..Herein, we explored mechanisms of ligand-independent progesterone receptor (PR) activity...
- The progesterone receptor hinge region regulates the kinetics of transcriptional responses through acetylation, phosphorylation, and nuclear retentionAndrea R Daniel
University of Minnesota Cancer Center, 420 Delaware Street SE, MMC 806, Minneapolis, Minnesota 55455, USA
Mol Endocrinol 24:2126-38. 2010..In sum, the PR hinge region is multifunctional. Understanding the ability of this region to couple acetylation, phosphorylation, and nuclear entry may provide clues to mechanisms of altered hormone responsiveness...
- Sequence and characterization of a coactivator for the steroid hormone receptor superfamilyS A Onate
Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA
Science 270:1354-7. 1995A yeast two-hybrid system was used to identify a protein that interacts with and enhances the human progesterone receptor (hPR) transcriptional activity without altering the basal activity of the promoter...
- Progesterone receptor polymorphisms and risk of breast cancer: results from two Australian breast cancer studiesSharon E Johnatty
Cancer and Cell Biology, Queensland Institute of Medical Research, c o Royal Brisbane Hospital Post Office, Herston, Brisbane, QLD, 4029, Australia
Breast Cancer Res Treat 109:91-9. 2008Association studies aimed at identifying breast cancer susceptibility variants in the progesterone receptor (PGR) gene have been previously reported in the literature with conflicting results, ranging from a protective effect conferred ..
- ck2-dependent phosphorylation of progesterone receptors (PR) on Ser81 regulates PR-B isoform-specific target gene expression in breast cancer cellsChristy R Hagan
Department of Medicine and Women s Cancer Program, University of Minnesota, Minneapolis, Minnesota, USA
Mol Cell Biol 31:2439-52. 2011....
- Evaluation of a hormone receptor-positive ovarian carcinoma subtype with a favourable prognosis by determination of progesterone receptor and oestrogen receptor 1 mRNA expression in formalin-fixed paraffin-embedded tissueBruno V Sinn
Institute of Pathology, Charite Universitatsmedizin Berlin, Germany
Histopathology 59:918-27. 2011..The aim of this study was to examine the prognostic role of progesterone receptor (PR) protein and mRNA expression.
- Nuclear factor 1 synergizes with progesterone receptor on the mouse mammary tumor virus promoter wrapped around a histone H3/H4 tetramer by facilitating access to the central hormone-responsive elementsGuillermo Pablo Vicent
Centre de Regulacio Genomica, Universitat Pompeu Fabra, Parc de Recerca Biomedica, Dr Aiguader 88, E 08003 Barcelona, Spain
J Biol Chem 285:2622-31. 2010..mammary tumor virus (MMTV) promoter progesterone induction is mediated by the reciprocal synergism between progesterone receptor (PR) and the ubiquitous transcription factor nuclear factor 1 (NF1)...
- Cyclin-dependent kinase activity is required for progesterone receptor function: novel role for cyclin A/Cdk2 as a progesterone receptor coactivatorRamesh Narayanan
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Mol Cell Biol 25:264-77. 2005Our studies examining the role of the cell cycle-regulated kinase cyclin A/Cdk2 in progesterone receptor (PR) action have demonstrated that cyclin-dependent kinase activity is required for PR function and that cyclin A/Cdk2 functions as ..
- Progesterone receptor rapid signaling mediates serine 345 phosphorylation and tethering to specificity protein 1 transcription factorsEmily J Faivre
Department of Medicine, Division of Hematology, Oncology, and Transplantation, University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
Mol Endocrinol 22:823-37. 2008..Our data demonstrate the therapeutic potential for PR-targeted breast cancer treatment by exploiting multiple nodes along the PR signaling pathway, including PR-B, EGFR, c-Src, MAPK, or Sp1...
- Accumulation of uPA-PAI-1 complexes inside the tumour cells is associated with axillary nodal invasion in progesterone-receptor-positive early breast cancerJ Schneider
Fundación Tejerina Centro de Patología de la Mama, Madrid, Spain
Br J Cancer 88:96-101. 2003..we found a statistically significant interaction between the presence of uPA-PAI-1 complexes and progesterone receptor positivity (P=0.04)...
- Repressors of androgen and progesterone receptor actionIrina U Agoulnik
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
J Biol Chem 278:31136-48. 2003..We found that although DAX-1 is expressed in normal human prostate, its expression is strongly reduced in benign prostatic hyperplasia suggesting that DAX-1 plays a role in limiting AR activity in prostate...
- No association between the progesterone receptor gene +331G/A polymorphism and breast cancerHeather Spencer Feigelson
Department of Epidemiology and Surveillance Research, American Cancer Society, 1599 Clifton Road NE, Atlanta GA 30309, USA
Cancer Epidemiol Biomarkers Prev 13:1084-5. 2004
- Estrogen and progesterone receptor gene polymorphisms and sporadic breast cancer risk: a Spanish case-control studyL P Fernandez
Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Centre CNIO, Madrid, Spain
Int J Cancer 119:467-71. 2006..Our results obtained in a European population confirm the protective role of the S10S variant in ESR1, previously reported in an Asian and a European-American population...
- Low activation of Insulin-like Growth Factor 1-Receptor (IGF1R) is associated with local recurrence in early breast carcinomaGloria Peiro
Research Unit, Hospital General Universitari d Alacant, c Pintor Baeza s n, 03010 Alacant, Spain
Breast Cancer Res Treat 117:433-41. 2009..Therefore, do not benefit from a boost dose on the surgical scar...
- Oncoprotein HCCR-1 expression in breast cancer is well correlated with known breast cancer prognostic factors including the HER2 overexpression, p53 mutation, and ER/PR statusSeon Ah Ha
Department of Molecular Genetic Laboratory, College of Medicine, The Catholic University of Korea, Seoul, Korea
BMC Cancer 9:51. 2009..The serum HCCR-1 assay is useful in diagnosing breast cancer and mice transgenic for HCCR developed breast cancers. But it is unknown how HCCR-1 contributes to human breast tumorigenesis...
- +331G/A variant in the progesterone receptor gene, postmenopausal hormone use and risk of breast cancerJoanne Kotsopoulos
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Int J Cancer 125:1685-91. 2009A functional promoter polymorphism in the progesterone receptor (PR) gene previously has been associated with an increased risk of postmenopausal breast cancer...
- Genetic variation in the progesterone receptor gene and risk of endometrial cancer: a haplotype-based approachEunjung Lee
Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90089, USA
Carcinogenesis 31:1392-9. 2010..The PROGINS allele of the progesterone receptor (PGR) gene reduces the function of PGR and has been associated with increased risk of the endometrioid ..
- Polymorphisms in VEGF, progesterone receptor and IL-1 receptor genes in women with recurrent spontaneous abortionEvelyn Traina
Obstetrics Departament, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
J Reprod Immunol 88:53-7. 2011..Here we investigate the relationship between RSA and gene polymorphisms of the progesterone receptor (PROGINS), interleukin-1 receptor 1 (PstI) and vascular endothelial growth factor (VEGF) (-634, 936)...
- The inhibitory function in human progesterone receptor N termini binds SUMO-1 protein to regulate autoinhibition and transrepressionHany Abdel-Hafiz
Department of Medicine, Molecular Biology Program, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
J Biol Chem 277:33950-6. 2002..We conclude that autoinhibition and transrepression involve N-terminal sumoylation combined with intramolecular N/C-terminal communication...
- Progesterone receptor modulator CDB-2914 down-regulates proliferative cell nuclear antigen and Bcl-2 protein expression and up-regulates caspase-3 and poly(adenosine 5'-diphosphate-ribose) polymerase expression in cultured human uterine leiomyoma cellsQin Xu
Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Chuo Ku, Kobe 650 0017, Japan
J Clin Endocrinol Metab 90:953-61. 2005The present study was conducted to evaluate the effects of the progesterone receptor modulator CDB-2914 on proliferative activity and apoptosis in cultured human uterine leiomyoma cells...
- Cooperative activation of cyclin D1 and progesterone receptor gene expression by the SRC-3 coactivator and SMRT corepressorSudipan Karmakar
Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Mol Endocrinol 24:1187-202. 2010..cancer cells, and we report herein the E2-dependent recruitment of SMRT to the regulatory regions of the progesterone receptor (PR) and cyclin D1 genes...
- Prokineticin 1, homeobox A10, and progesterone receptor messenger ribonucleic acid expression in primary cultures of endometrial stromal cells isolated from endometrium of healthy women and from eutopic endometrium of women with endometriosisFederica Tiberi
Istituto Scientifico Internazionale Paolo VI, Università Cattolica del Sacro Cuore UCSC, Rome, Italy
Fertil Steril 94:2558-63. 2010....
- Estrogen and progesterone receptor subtype expression in normal and malignant ovarian epithelial cell culturesAndrew J Li
Department of Obstetrics and Gynecology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
Am J Obstet Gynecol 189:22-7. 2003..Epidemiologic data suggest that the malignant transformation of ovarian epithelium may be linked to altered steroid hormone homeostasis...
- Progesterone receptors (PR)-B and -A regulate transcription by different mechanisms: AF-3 exerts regulatory control over coactivator binding to PR-BLin Tung
Department of Medicine, RC1 South, 12801 East 17th Avenue, P O Box 6511, Aurora, Colorado 80045, USA
Mol Endocrinol 20:2656-70. 2006..In sum, AF3 in BUS plays a critical modulatory role in PR-B, and in doing so, defines a mechanism for PR-B function that is fundamentally distinct from that of PR-A...
- Estrogens and progesterone promote persistent CCND1 gene activation during G1 by inducing transcriptional derepression via c-Jun/c-Fos/estrogen receptor (progesterone receptor) complex assembly to a distal regulatory element and recruitment of cyclin D1 tLuigi Cicatiello
Dipartimento di Patologia Generale, Seconda Universita degli Studi di Napoli, 80138 Naples, Italy
Mol Cell Biol 24:7260-74. 2004....
- Negative interaction between the RelA(p65) subunit of NF-kappaB and the progesterone receptorE Kalkhoven
Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht
J Biol Chem 271:6217-24. 1996..describes the mutual repression of two transcription factors, the RelA(p65) subunit of NF-kappaB and the progesterone receptor (PR)...
- p27KIP-1, cyclin A and cyclin D1 protein expression in ductal carcinoma in situ of the breast: p27KIP-1 correlates with hormone receptor status but not with local recurrenceEwan K A Millar
Department of Anatomical Pathology, South Eastern Area Laboratory Service, St George Hospital, NSW, Australia
Pathol Int 57:183-9. 2007..There was a highly significant positive association between p27(KIP-1) and estrogen receptor/progesterone receptor (ER/PR) status (P = 0.002, P = 0.02) and with p27(KIP-1) and cyclin D1 expression (P = 0.002)...
- Coactivator assembly at the promoter: efficient recruitment of SRC2 is coupled to cooperative DNA binding by the progesterone receptorAaron F Heneghan
Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, Colorado 80262, USA
Biochemistry 46:11023-32. 2007..We have previously resolved the microstate interaction energetics of progesterone receptor A-isoform (PR-A) assembly at multiple promoters; here we extend this work to the role of PR-A in mediating ..
- Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26S proteasomeC A Lange
Department of Medicine, The Molecular Biology Program, and The Colorado Cancer Center, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Proc Natl Acad Sci U S A 97:1032-7. 2000..Specifically, down-regulation of mature PRs occurs by a mechanism in which ligand binding activates PR phosphorylation by MAPKs at a unique serine residue, which then targets the receptors for degradation...
- ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional activationN Kotaja
Department of Physiology, Institute of Biomedicine, University of Helsinki, Finland
Mol Endocrinol 14:1986-2000. 2000..more efficiently than Miz1 or PIAS1, and all PIAS proteins also activate estrogen receptor- and progesterone receptor-dependent transcription but to a dissimilar degree...
- Genetic variation in the progesterone receptor gene and ovarian cancer riskKathryn L Terry
Obstetrics and Gynecology Epidemiology Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Am J Epidemiol 161:442-51. 2005..Thus, genetic variations that may cause alterations in the biologic functions of the progesterone receptor can potentially contribute to individual susceptibility to ovarian cancer...
- Up-regulation of the progesterone receptor (PR)-C isoform in laboring myometrium by activation of nuclear factor-kappaB may contribute to the onset of labor through inhibition of PR functionJennifer C Condon
Department of Biochemistry, North Texas March of Dimes Birth Defects Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9038, USA
Mol Endocrinol 20:764-75. 2006Progesterone acting via the progesterone receptor (PR) plays a critical role in maintaining uterine quiescence during pregnancy...
- Induction of progesterone target genes requires activation of Erk and Msk kinases and phosphorylation of histone H3Guillermo P Vicent
Centre de Regulacio Genomica, Universitat Pompeu Fabra, Parc de Recerca Biomedica, Dr Aiguader 88, E 08003 Barcelona, Spain
Mol Cell 24:367-81. 2006..Five minutes after hormone treatment, Erk activation leads to phosphorylation of the progesterone receptor (PR), activation of Msk1, and recruitment of a complex of the three proteins to a nucleosome on the MMTV ..
- High-mobility group chromatin proteins 1 and 2 functionally interact with steroid hormone receptors to enhance their DNA binding in vitro and transcriptional activity in mammalian cellsV Boonyaratanakornkit
Department of Pathology and Molecular Biology Program, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Mol Cell Biol 18:4471-87. 1998..the chromatin high-mobility group protein 1 (HMG-1) enhances the sequence-specific DNA binding activity of progesterone receptor (PR) in vitro, thus providing the first evidence that HMG-1 may have a coregulatory role in steroid ..
- The Angelman syndrome-associated protein, E6-AP, is a coactivator for the nuclear hormone receptor superfamilyZ Nawaz
Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Mol Cell Biol 19:1182-9. 1999..protein (E6-AP/UBE3A) directly interacts with and coactivates the transcriptional activity of the human progesterone receptor (PR) in a hormone-dependent manner...
- PROGINS receptor gene polymorphism is associated with endometriosisFritz Wieser
Department of Obstetrics and Gynecology, Division of Gynecological Endocrinology and Reproductive Medicine, University of Vienna, Waeringer Guertel 18 20, A 1090 Vienna, Austria
Fertil Steril 77:309-12. 2002To investigate the association between the 306-base pair insertion polymorphism in intron G of the progesterone receptor (PROGINS) and endometriosis.
- Decreased progesterone receptor expression in the intermediate trophoblastic cells of spontaneous abortionsTimothy N Hickman
Department of Gynecology and Obstetrics, Division of Reproductive Endocrinology and Infertility, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Fertil Steril 77:1001-5. 2002To determine whether there are differences in the expression of progesterone receptor (PR) in intermediate trophoblastic cells of pregnancies ending in either spontaneous abortion (SAB) or elective abortion.
- New human breast cancer cells to study progesterone receptor isoform ratio effects and ligand-independent gene regulationBritta M Jacobsen
Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Biol Chem 277:27793-800. 2002All known progesterone target cells coexpress two functionally different progesterone receptor (PR) isoforms: 120-kDa B-receptors (PR-B) and N-terminally truncated, 94-kDa A-receptors (PR-A)...
- Progesterone receptor activates its promoter activity in human endometrial stromal cellsMeiyi Tang
Department of Obstetrics Gynecology and Reproductive Medicine, School of Medicine, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
Mol Cell Endocrinol 192:45-53. 2002Previous studies have shown that progestin increases the content of progesterone receptor (hPRA and hPRB) and the hPR mRNA during decidualization of human endometrial stromal cells suggesting that endogenous hPR enhances the ..
- Immunohistochemical analysis of 1,25-dihydroxyvitamin-D3-receptors, estrogen and progesterone receptors and Ki-67 in ovarian carcinomaCarlos Villena-Heinsen
Department of Gynecology, University of Saarland, Homburg, Germany
Anticancer Res 22:2261-7. 2002..The aim of this study was to analyze immunohistochemically the expression of VDR in normal and carcinomatous ovarian tissue to evaluate whether ovarian tissue may be a new potential target for biologically active vitamin D analogues...
- Sumoylation of the progesterone receptor and of the steroid receptor coactivator SRC-1Anne Chauchereau
INSERM U135, Hormones, Genes, and Reproduction, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre, France
J Biol Chem 278:12335-43. 2003..We show here that SUMO-1 overexpression markedly enhances progesterone receptor (PR)-mediated gene transcription...
- Insulin-like growth factor-I inhibits progesterone receptor expression in breast cancer cells via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway: progesterone receptor as a potential indicator of growth factor activity in breaXiaojiang Cui
Breast Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Mol Endocrinol 17:575-88. 2003..In this study, we found that IGF-I sharply lowers progesterone receptor (PR) mRNA and protein levels in breast cancer cells...
- Novel isoforms of the mRNA for human female sex steroid hormone receptorsShuji Hirata
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Yamanashi, Shimokato 1110, Tamaho, Nakakoma, Yamanashi 409 3898, Japan
J Steroid Biochem Mol Biol 83:25-30. 2002..In the present communication, our recent data along with others on the novel isoform/variant mRNAs for the human female sex steroid hormone receptors will be summarized...
- Novel alternatively spliced variant with a deletion of 52 BP in exon 6 of the progesterone receptor gene is observed frequently in breast cancer tissuesHisashi Hisatomi
Center for Molecular Biology and Cytogenetics, SRL Inc, Tokyo, Japan
Int J Cancer 105:182-5. 2003The human progesterone receptor (PR) is a ligand-activated nuclear transcription factor that mediates progesterone action in target tissues. We found a novel alternatively spliced variant (ASV) of the PR mRNA in breast cancer tissues...
- Human progesterone receptor polymorphisms and implantation failure during in vitro fertilizationDaniel W Cramer
Department of Obstetrics, Gynecology and Reproductive Biology, Ob Gyn Epidemiology Center, 221 Longwood Avenue, Brigham and Women s Hospital, Boston, MA, USA
Am J Obstet Gynecol 189:1085-92. 2003Polymorphic variants of the human progesterone receptor gene have been described, but their potential influence on in vitro fertilization outcome have not been studied.
- Fos and Jun inhibit estrogen-induced transcription of the human progesterone receptor gene through an activator protein-1 siteLarry N Petz
Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, 524 Burrill Hall, 407 South Goodwin Avenue, Urbana, Illinois 61801, USA
Mol Endocrinol 18:521-32. 2004The progesterone receptor (PR) gene is activated by estrogen in normal reproductive tissues and in MCF-7 human breast cancer cells...
- Molecular chaperones function as steroid receptor nuclear mobility factorsCem Elbi
Laboratory of Receptor Biology and Gene Expression, Building 41, Room B602, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 5055, USA
Proc Natl Acad Sci U S A 101:2876-81. 2004..Thus, our results provide a description of soluble nuclear mobility factors and furthermore demonstrate a previously unrecognized role for molecular chaperones in the regulation of steroid receptor function within the nucleus...
- Transcriptional cross talk between the forkhead transcription factor forkhead box O1A and the progesterone receptor coordinates cell cycle regulation and differentiation in human endometrial stromal cellsMasashi Takano
Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, United Kingdom
Mol Endocrinol 21:2334-49. 2007..Using a glutathione-S-transferase pull-down assay, we confirmed that FOXO1 interacts with progesterone receptor, irrespectively of the presence of ligand...
- Single nucleotide polymorphisms in the human progesterone receptor gene and spontaneous preterm birth- Guoyang Luo
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA
Reprod Sci 15:147-55. 2008Progesterone supplementation can prevent preterm birth in some high-risk women. Progesterone binds to progesterone receptor (PR) and modulates the expression of target genes...
- The human progesterone receptor shows evidence of adaptive evolution associated with its ability to act as a transcription factorCaoyi Chen
Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
Mol Phylogenet Evol 47:637-49. 2008The gene encoding the progesterone receptor (PGR) acts as a transcription factor, and participates in the regulation of reproductive processes including menstruation, implantation, pregnancy maintenance, parturition, mammary development, ..
- Systematic expression analysis and antibody screening do not support the existence of naturally occurring progesterone receptor (PR)-C, PR-M, or other truncated PR isoformsAnnemarie Samalecos
Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany
Endocrinology 149:5872-87. 2008..Thus, the 60-kDa protein called PR-C does not originate from AUG-595 and is not a naturally occurring PR isoform...
- Comparing expression of progesterone and estrogen receptors in testicular tissue from men with obstructive and nonobstructive azoospermiaYibing Han
Department of Obstetrics and Gynaecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, SAR, China
J Androl 30:127-33. 2009The objective of this study was to identify and compare the expression profiles of progesterone receptor (PR) and estrogen receptor alpha (ERalpha) in the testes of men with obstructive azoospermia (OA), maturation arrest (MA), and ..
- Progesterone receptor variants found in breast cells repress transcription by wild-type receptorsJ K Richer
Department of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
Breast Cancer Res Treat 48:231-41. 1998..We propose that expression of variant PR can compromise the accuracy of receptor measurements as markers of hormone-dependent cancers, and can modify the responses of tumors to progestin therapies...
- Variant estrogen and progesterone receptor messages in human vascular smooth muscleY K Hodges
Department of Medicine, Division of Cardiology, University of Colorado Health Sciences Center, Denver, Colo 80262, USA
Circulation 99:2688-93. 1999..Therefore, we analyzed the structure of estrogen receptors (ERs) and progesterone receptors (PRs) in human vascular smooth muscle...
- The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor bindingP H Giangrande
Department of Pharmacology, Duke University Medical Center, Durham, North Carolina 27710, USA
Mol Cell Biol 20:3102-15. 2000The human progesterone receptor (PR) exists as two functionally distinct isoforms, hPRA and hPRB...
- Ligand-activated progesterone receptor isoform hPR-A is a stronger transactivator than hPR-B for the expression of IGFBP-1 (insulin-like growth factor binding protein-1) in human endometrial stromal cellsJ Gao
Department of Obstetrics Gynecology and Reproductive Medicine, School of Medicine, State University of New York at Stony Brook, 11794, USA
Mol Endocrinol 14:1954-61. 2000In human endometrium, the levels of progesterone receptor (PR) isoforms hPR-A and hPR-B are differentially regulated during the reproductive cycle...
- Progesterone receptor contains a proline-rich motif that directly interacts with SH3 domains and activates c-Src family tyrosine kinasesV Boonyaratanakornkit
University of Colorado School of Medicine, Pathology Department and Molecular Biology Program, Denver, CO 80262, USA
Mol Cell 8:269-80. 2001..We have identified a specific polyproline motif in the amino-terminal domain of conventional progesterone receptor (PR) that mediates direct progestin-dependent interaction of PR with SH3 domains of various cytoplasmic ..
- Differential gene regulation by the two progesterone receptor isoforms in human breast cancer cellsJennifer K Richer
Department of Medicine Endocrinology, University of Colorado School of Medicine, Denver, Colorado 80262, USA
J Biol Chem 277:5209-18. 2002..Additionally, use of natural target genes, rather than "consensus" response elements, for transcription studies should improve our understanding of steroid hormone action...
- The novel exon, exon T, of the human progesterone receptor gene and the genomic organization of the geneShuji Hirata
Department of Obstetrics and Gynecology, Yamanashi Medical University, Shimokato 1110, Tamaho, Nakakoma 409 3898, Japan
J Steroid Biochem Mol Biol 80:365-7. 2002Recently, we have cloned the novel isoform of the progesterone receptor (PR) cDNA (PR isoform S cDNA) from the human testicular cDNA library...
- The progesterone receptor exon 4 Val660Leu G/T polymorphism and risk of breast cancer in Australian womenAmanda B Spurdle
Oncology Division, Joint Experimental Oncology Programme, The Queensland Institute of Medical Research, and The University of Queensland, Brisbane, 4029, Australia
Cancer Epidemiol Biomarkers Prev 11:439-43. 2002An Alu insertion polymorphism of the progesterone receptor (PR) wasreported recently to be associated with a reduced risk of breast cancer, with risks of 0.8- and 0...
- Human progesterone receptor gene polymorphism PROGINS and risk for breast cancer in Austrian womenGerhild Fabjani
Department of Obstetrics and Gynecology, General Hospital of Vienna, University of Vienna
Breast Cancer Res Treat 72:131-7. 2002A germline TaqI restriction fragment length polymorphism in the intron G of the progesterone receptor (PR) gene designated PROGINS was described to be associated with an increased risk for ovarian carcinoma...
- Differential expression of progesterone receptor isoforms A and B in the normal ovary, and in benign, borderline, and malignant ovarian tumorsJun ichi Akahira
Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Aoba ku, Sendai 980 8574, Japan
Jpn J Cancer Res 93:807-15. 2002..In this study, we examined the differential expression patterns of the two progesterone receptor (PR) isoforms, PRA and PRB, using immunohistochemistry and real-time quantitative RT-PCR in normal and ..
- A functional polymorphism in the promoter of the progesterone receptor gene associated with endometrial cancer riskImmaculata De Vivo
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 99:12263-8. 2002..Because the antiproliferative effect of progesterone requires the progesterone receptor (PR), which exists in two isoforms, PR-A and -B, we reasoned that variants in the PR gene may predispose ..
- Progesterone receptor mRNA variant containing novel exon insertions between exon 4 and exon 5 in human uterine endometriumTomoya Yamanaka
Department of Obstetrics and Gynecology, Yamanashi Medical University, Tamaho, Nakakoma, Japan
Endocr J 49:473-82. 2002The presence of human progesterone receptor (PR) mRNA variants has been demonstrated in uterine endometrium and breast tissues as well as in cancer cells of these tissues...
- Estrogen receptor alpha and activating protein-1 mediate estrogen responsiveness of the progesterone receptor gene in MCF-7 breast cancer cellsLarry N Petz
Department of Molecular and Integrative Physiology, University of Illinois, Urbana, Illinois 61801, USA
Endocrinology 143:4583-91. 2002The progesterone receptor (PR) gene is activated by estrogen in MCF-7 human breast cancer cells...
- Cyclic changes in the expression of steroid receptor coactivators and corepressors in the normal human endometriumTanri Shiozawa
Department of Obstetrics and Gynecology, Shinshu University School of Medicine, Matsumoto 390 8621, Japan
J Clin Endocrinol Metab 88:871-8. 2003..Cyclic change in the expression of SRC-1 during the menstrual cycle might be important in the estrogen-action for the glandular and stromal cells...
- Expression of a novel splicing variant deleting exons 4 and 6 of the progesterone receptor gene is a rare event in breast cancerKumi Nagao
Center for Molecular Biology and Cytogenetics, SRL, Inc, Tokyo 191 0002, Japan
Oncol Rep 10:305-8. 2003..The expressions of ASVs that induced the mimic PR transcripts need to be considered when designing strategies for regulation analysis of the PR gene...
- Cloning and expression of a novel, truncated, progesterone receptorKarla J Saner
Department of Microbiology and Molecular Medicine, Clemson University, SC, USA
Mol Cell Endocrinol 200:155-63. 2003Progesterone acts via two specific receptors to affect gene transcription in target tissues. Progesterone receptor (PR) B contains 933 amino acids while PR A is a truncated version lacking the initial 164 amino acids...
- A functional polymorphism in the progesterone receptor gene is associated with an increase in breast cancer riskImmaculata De Vivo
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Cancer Res 63:5236-8. 2003..Because the effects of progesterone require the progesterone receptor (PGR), which exists in two isoforms, PR-A and PR-B, we sought to determine whether the functional ..
- Association of progesterone receptor polymorphism with recurrent abortionsAndreas Schweikert
Division of Gynecological Endocrinology and Reproductive Medicine, Department of Obstetrics and Gynecology, University of Erlangen Nurnberg, Universitätsstrasse 21 23, 91054 Erlangen, Germany
Eur J Obstet Gynecol Reprod Biol 113:67-72. 2004The current study sought for polymorphisms within the progesterone receptor (PR) gene. Allele and genotype frequencies of patients with repeated abortions were compared to a control group.
- Differential regulation of the human progesterone receptor gene through an estrogen response element half site and Sp1 sitesLarry N Petz
Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, 524 Burrill Hall, 407 South Goodwin Avenue, Urbana, IL 61801, USA
J Steroid Biochem Mol Biol 88:113-22. 2004The progesterone receptor (PR) gene is regulated by estrogen in normal reproductive tissues and in MCF-7 human breast cancer cells...
- Breast cancer patients with progesterone receptor PR-A-rich tumors have poorer disease-free survival ratesTorsten A Hopp
Department of Medicine, and Breast Center, Baylor College of Medicine, Houston, Texas 77030, USA
Clin Cancer Res 10:2751-60. 2004No study has yet analyzed whether changes in relative expression levels of progesterone receptor (PR) isoforms A and B in human breast tumors have significance in predicting clinical outcome...
- The progesterone receptor Val660-->Leu polymorphism and breast cancer riskImmaculata De Vivo
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
Breast Cancer Res 6:R636-9. 2004..its receptor; thus, genetic variations, which might cause alterations in the biological function in the progesterone receptor (PGR), can potentially contribute to an individual's susceptibility to breast cancer...
- Progesterone-independent effects of human progesterone receptors (PRs) in estrogen receptor-positive breast cancer: PR isoform-specific gene regulation and tumor biologyBritta M Jacobsen
Department of Medicine, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
Mol Endocrinol 19:574-87. 2005....
- A germline variation in the progesterone receptor gene increases transcriptional activity and may modify ovarian cancer riskIrina U Agoulnik
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
J Clin Endocrinol Metab 89:6340-7. 2004Recently, we and others have detected a haplotype of the human progesterone receptor gene (PR). This haplotype consists of a 320-bp insertion in intron G together with point mutations in exons 4 and 5 and was named PROGINS...
- Progesterone receptor promoter +331A polymorphism is associated with a reduced risk of endometrioid and clear cell ovarian cancersAndrew Berchuck
Division of Gynecologic Oncology, Duke University Medical Center, Box 3079, Durham, NC 27710, USA
Cancer Epidemiol Biomarkers Prev 13:2141-7. 2004..A functional single nucleotide polymorphism in the promoter of the progesterone receptor (+331A) alters the relative abundance of the A and B isoforms and has been associated with an increased ..
- Ligand-specific dynamics of the progesterone receptor in living cells and during chromatin remodeling in vitroGeetha V Rayasam
Laboratory of Receptor Biology and Gene Expression, Building 41, B602, National Cancer Institute, National Institutes of Health, 41 Library Dr, Bethesda, MD 20892 5055, USA
Mol Cell Biol 25:2406-18. 2005b>Progesterone receptor (PR), a member of the nuclear receptor superfamily, is a key regulator of several processes in reproductive function...
- Human progesterone receptor displays cell cycle-dependent changes in transcriptional activityRamesh Narayanan
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Mol Cell Biol 25:2885-98. 2005The human progesterone receptor (PR) contains multiple Ser-Pro phosphorylation sites that are potential substrates for cyclin-dependent kinases, suggesting that PR activity might be regulated during the cell cycle...
- The breast cancer susceptibility gene BRCA1 regulates progesterone receptor signaling in mammary epithelial cellsYongxian Ma
Department of Oncology, Lombardi Cancer Center, Georgetown University, Washington, DC 20057 1469, USA
Mol Endocrinol 20:14-34. 2006The progesterone receptor (PR) plays roles in normal mammary development and breast cancer formation, where it may exert both stimulatory and inhibitory actions...
- Variant progesterone receptor mRNAs are co-expressed with the wild-type progesterone receptor mRNA in human endometrium during all phases of the menstrual cycleP B Marshburn
Division of Reproductive Endocrinology and Infertility, Carolinas Medical Center, Charlotte, NC 28232, USA
Mol Hum Reprod 11:809-15. 2005b>Progesterone receptor (PR) variant mRNAs in human endometrium could encode proteins with the potential to alter progesterone action in states of normal and abnormal endometrial development...
- Dual roles for the phosphatase PPM1D in regulating progesterone receptor functionDavid A Proia
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
J Biol Chem 281:7089-101. 2006..We found that PPM1D stimulated the activity of several nuclear receptors including the progesterone receptor (PR) and estrogen receptor...
- Two functionally relevant polymorphisms in the human progesterone receptor gene (+331 G/A and progins) and the predisposition for breast and/or ovarian cancerAndrea Romano
Department of Obstetrics and Gynaecology, University Hospital of Maastricht, The Netherlands
Gynecol Oncol 101:287-95. 2006Two polymorphisms affecting either expression (+331 G/A) or transcriptional activity (progins) of the progesterone receptor have been described. No clear correlation between either polymorphism and breast or ovarian cancer has been shown...
- Progesterone signaling in human myometrium through two novel membrane G protein-coupled receptors: potential role in functional progesterone withdrawal at termEmmanouil Karteris
Division of Clinical Science, University of Warwick, Coventry, UK
Mol Endocrinol 20:1519-34. 2006..Our data indicate the presence of a novel signaling pathway mediated by mPRs that may result in a functional progestin withdrawal, shifting the balance from a quiescent state to one of contraction...
- Association of the progesterone receptor gene with breast cancer risk: a single-nucleotide polymorphism tagging approachKaren A Pooley
Department of Oncology, Cancer Research UK, University of Cambridge, Strangeways Research Laboratory
Cancer Epidemiol Biomarkers Prev 15:675-82. 2006Association studies on susceptibility to breast cancer using single nucleotide polymorphisms (SNP) in the progesterone receptor (PGR) gene have been previously published, but the results have been inconclusive...
- Progesterone receptor plays a major antiinflammatory role in human myometrial cells by antagonism of nuclear factor-kappaB activation of cyclooxygenase 2 expressionDaniel B Hardy
Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9038, USA
Mol Endocrinol 20:2724-33. 2006..is likely mediated by a concerted series of biochemical events that negatively impact the ability of the progesterone receptor (PR) to regulate target genes that maintain myometrial quiescence...
- Progesterone receptor polymorphism +331G/A is associated with a decreased risk of deep infiltrating endometriosisK J A F van Kaam
Research Institute GROW, University of Maastricht, The Netherlands
Hum Reprod 22:129-35. 2007Alterations in the progesterone receptor (PR) are considered a risk factor for the development of endometriosis...
- Focal subnuclear distribution of progesterone receptor is ligand dependent and associated with transcriptional activityRebecca L Arnett-Mansfield
Westmead Institute for Cancer Research, Westmead Hospital, Westmead, New South Wales 2145, Australia
Mol Endocrinol 21:14-29. 2007The progesterone receptor (PR) is a critical mediator of progesterone action in the female reproductive system...
- The progesterone receptor gene polymorphism, PROGINS, may be a factor related to the development of uterine fibroidsMariano Tamura Vieira Gomes
Department of Gynecology, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
Fertil Steril 87:1116-21. 2007To assess the possible association between the polymorphic allele of the progesterone receptor gene, named PROGINS, and uterine leiomyomas.
- Genetic polymorphisms of cytochrome P450cl7alpha (CYP17) and progesterone receptor genes (PROGINS) in the assessment of endometriosis riskCristina Valleta De Carvalho
Molecular Gynecology Laboratory, Federal University of Sao Paulo, Sao Paulo, Brazil
Gynecol Endocrinol 23:29-33. 2007..evaluate the eventual role of polymorphisms in the genes encoding cytochrome P450c17alpha (CYP17) and the progesterone receptor (PROGINS) as risk factors for endometriosis development...
- Association of progesterone receptor gene polymorphism (PROGINS) with endometriosis, uterine fibroids and breast cancerS Govindan
Department of Genetics, Vasavi Medical and Research Centre, Khairtabad, Hyderabad 500 004, Andhra Pradesh, India
Cancer Biomark 3:73-8. 2007..study has been carried out to identify the association of 306bp Alu insertion polymorphism in intron 7 of progesterone receptor gene (PROGINS)...
- Association of progesterone receptor polymorphisms with recurrent implantation failure after in vitro fertilization and embryo transferCarolyn B Coulam
Pregnancy Success Center of Rinehart Center for Reproductive Medicine, Evanston, IL, USA
J Assist Reprod Genet 25:119-22. 2008..The actions of progesterone are mediated by the progesterone receptor. Polymorphic variants of human progesterone receptor genes have been implicated in implantation failure.
- The androgen and progesterone receptors regulate distinct gene networks and cellular functions in decidualizing endometriumBrianna Cloke
Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, London W12 0NN, United Kingdom
Endocrinology 149:4462-74. 2008..By combining small interfering RNA technology with genome-wide expression profiling, we found that AR and progesterone receptor (PR) regulate the expression of distinct decidual gene networks...
- Polymorphisms in genes involved in sex hormone metabolism, estrogen plus progestin hormone therapy use, and risk of postmenopausal breast cancerBrenda Diergaarde
Cancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center and Department of Epidemiology, University of Washington, Seattle, WA, USA
Cancer Epidemiol Biomarkers Prev 17:1751-9. 2008..Our results support the hypothesis that specific polymorphisms in genes involved in sex hormone metabolism may modify the effect of E+P use on breast cancer risk...
- Michael J Soares; Fiscal Year: 2014..estrogen receptor alpha (ESR1) and estrogen receptor beta (ESR2), while progesterone signals through the progesterone receptor (PGR)...
- Richard L Stouffer; Fiscal Year: 2015..Recent evidence suggests that specific genomic progesterone receptor isoforms (PGR-A and -B) regulate different activities in target tissue;and the discovery of nongenomic PGR ..
- Ruth Lupu; Fiscal Year: 2014..Receptor positive (ER+), HER2 3+ overexpressing (HER2+) and triple negative (TN) [which do not express ER, Progesterone Receptor (PgR), and HER2+)...
- ESTROGENIC REGULATION OF MAMMARY PROGESTERONE RECEPTORSG Shyamala; Fiscal Year: 1990..the activation and/or interaction of mammary ER with DNA nd chromatin; (2) to characterize the mammary progesterone receptor (PgR) in detail with emphasis on receptor heterogeneity and subunit composition; (3) to examine whether ..
- Flaxseed vs. aromatase inhibitors: breast tumor characteristics and prognosisSusan McCann; Fiscal Year: 2009....
- Dietary lignan effects on hormone, growth, and signaling factors in breast tumorsSusan McCann; Fiscal Year: 2009..The results of this study may provide us with important information that can be useful in understanding the effect of diet on development of different breast cancer sub-types. ..
- MECHANISM OF HORMONAL CONTROL OF MAMMARY CARCINOMASuzanne Fuqua; Fiscal Year: 1993....
- MECHANISM OF HORMONAL CONTROL OF MAMMARY CARCINOMAWILLIAM MC GUIRE; Fiscal Year: 1992....
- Development and validation of predictors of endocrine treatment sensitivityChristos Hatzis; Fiscal Year: 2007..for prediction of response to adjuvant tamoxifen therapy compared to standard markers such as ER and the progesterone receptor (PGR)...
- Estrogen and Progesterone-related Gene Variants and Colorectal Cancer RiskShumin Zhang; Fiscal Year: 2009....
- Breast cancer and HRT: genetic susceptibility within th*Kathleen Malone; Fiscal Year: 2006..exogenous progesterone may influence carcinogenesis is through its proliferative effect on cells via the progesterone receptor B (PRB) and the differential metabolism of exogenous progesterone affecting the availability of ..
- Ethics and Safeguards in Psychiatric ResearchLaura W Roberts; Fiscal Year: 2010..Our proposed endeavor will generate new knowledge for wide dissemination and publication that can inform future evidence-based PGR ethics guidelines and generate further empirical ethics research on PGR. ..
- GENERATION OF AN INDUCIBLE SYSTEM IN THE UTERINE STROMA FOR IMPLANTATION STUDIESLiang Ma; Fiscal Year: 2013..This mouse strain should be a valuable tool for researchers studying implantation as well as embryonic or postnatal organogenesis and carcinogenesis. ..
- JERAMIAH JAMES SMITH; Fiscal Year: 2016..These studies are expected to provide unique insight into vertebrate genome biology and yield information that might not be achievable outside of the context of PGR. ..
- Chris T Amemiya; Fiscal Year: 2014..The inadequacy of the lamprey genome sequence, however, is highly problematic for researchers studying this organism. Development of an improved lamprey genome sequence is thus imperative for the community. ..
- LIGHT DURING DARKNESS AND BREAST CANCER PROGRESSIONDavid Blask; Fiscal Year: 2004..dose-response effects of exposure of nude female rats, bearing tissue-isolated estrogen receptor (ER)+ and progesterone receptor (PgR)+ MCF-7 human breast cancer xenografts, to different intensities of white light during darkness, on ..
- RECEPTOR MEDIATED RADIATION ONCOLOGYWILLIAM BLOOMER; Fiscal Year: 1991....
- Immunotoxicity of indirubin, a plant-based AhR ligandCharles Rice; Fiscal Year: 2005..The following proposal tests the hypothesis that indirubin is a potent immunotoxic compound. ..
- FLUORESCENT STEROID BINDING IN ENDOMETRICAL CARCINOMADONALD TOURVILLE; Fiscal Year: 1992..Conventional biochemical estrogen (ER) and progesterone receptor (PgR) assays are difficult to perform and interpret in this malignancy since specimens often contain ..
- FLUORESCENT STEROID CONJUGATES FOR ER AND PR STUDIESGary Chamness; Fiscal Year: 1990....
- MOLECULAR MODULATION OF HSV VECTOR CNS INTERACTIONSJohn Olschowka; Fiscal Year: 2003..The effectiveness of each manipulation will be assayed with the same methods used in Specific Aim 1. ..
- ENZYMES IN EICOSANOID METABOLISMHsin Hsiung Tai; Fiscal Year: 2004..Furthermore, the program should uncover novel properties of 5-HEDH and shed some light on the role of this enzyme in the inflammatory and allergic reactions. ..
- Molecular Diagnostics for Breast CancerPhilip Bernard; Fiscal Year: 2004..Multivariate analyses will be used to show statistical significance of molecular classifications. This study should provide a framework for molecular diagnostic testing of solid tumors in the clinical laboratory. ..
- QUANTITATION AND ARCHIVING OF GENE EXPRESSIONJohn Gerdes; Fiscal Year: 2000..An improved and more precise method of detecting gene expression levels that have been shown to be of prognostic and therapeutic importance has great commercialization potential. ..
- Gene Interactions, Estrogen, and Risk of Breast CancerKathleen Egan; Fiscal Year: 2006..abstract_text> ..
- OVINE INTERFERON-TAU REGULATES UTERINE HORMONE RECEPTORFuller Bazer; Fiscal Year: 2005....
- Bridges to the Doctorate in Reproductive BiologyFuller Bazer; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Whole genome amplification and DNA pooling strategiesImmaculata DeVivo; Fiscal Year: 2004..Results from the pooling experiments will determine whether this method may be sensitive enough for use in nested case-control studies where a small difference in allele frequency is expected. ..
- Pharmacogenetic Epidemiology of Birth Defects and CancerTimothy Rebbeck; Fiscal Year: 2004....
- Progesterone regulation of human luteal cell viabilityJohn Peluso; Fiscal Year: 2006..Such selective manipulation of the P4's actions could have far reaching effects on the treatment for infertility, contraception and certain types of cancers. [unreadable] [unreadable]..
- Protein Kinase G Regulation of Granulosa Cell ViabilityJohn Peluso; Fiscal Year: 2006..We now propose to test this hypothesis using biochemical, genetic, imaging and cell biological techniques. [unreadable] [unreadable]..
- The Progesterone Receptor Gene and Ovarian Cancer RiskCELESTE PEARCE; Fiscal Year: 2005The progesterone receptor gene (PGR) is a strong candidate gene for invasive epithelial ovarian cancer (ovarian cancer) susceptibility based on both experimental and epidemiologic observations...
- Regulation of Oocyte Viability by Granulosa Cell ContactJohn Peluso; Fiscal Year: 2004..abstract_text> ..
- Ovarian Cancer and Gonadotropin SignalingCELESTE PEARCE; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- A Pooled Analysis to Identify New Ovarian Cancer Risk FactorsCeleste Leigh Pearce; Fiscal Year: 2010..Gaining a better understanding of ovarian cancer, which this project will provide, is critical to identifying women at risk and for improving the outcome for women who are diagnosed with this disease. ..
- ANTIOXIDANTS AND FEMALE HORMONES IN THE ETIOLOGY OF RAElizabeth Karlson; Fiscal Year: 2002..RA will be confirmed by a screening questionnaire regarding rheumatic symptoms and review of medical records. The study will identify potentially modifiable risk factors for primary prevention of RA. ..
- FSHD Syndrome: DNA Repeats, Methylation, & ChromatinMelanie Ehrlich; Fiscal Year: 2003..The proposed research should help elucidate the molecular etiology of the enigmatic FSHD syndrome. ..
- Fox Chase Cancer Center Breast Cancer Tissue ResourcesJose Russo; Fiscal Year: 2008..abstract_text> ..
- Regulation of Pregnancy-Dependent AdaptationsMichael Soares; Fiscal Year: 2009..Novel ideas and a novel research approach have been presented to elucidate regulatory mechanisms controlling fundamental processes essential for the establishment and maintenance of pregnancy. ..
- MOUSE CANCER MODELS BY REGULATED INACTIVATION OF TUMOR SEva Lee; Fiscal Year: 2003..These valuable mouse models will be extremely useful for the general community of cancer researchers. ..
- Dendritic Processing in the Olfactory BulbJason Christie; Fiscal Year: 2003..The specific aims are: (1) to determine the function of autoexcitation in mitral cell processing and (2) to determine how dendritic compartmentalization effects mitral cell processing. ..
- Nutrition, Fetal Growth, and Placental AngiogenesisLawrence P Reynolds; Fiscal Year: 2010..abstract_text> ..
- Epigenetic Changes Induced by Estrogens and Xenoestrogens in Breast CancerJose Russo; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- CASE CONTROL STUDY OF OVARIAN CANCER HORMONAL ETIOLOGYHarvey Risch; Fiscal Year: 2002....
- DNA POLYMORPHISMS IN OVARIAN CANCER--CASE CONTROL STUDYHarvey Risch; Fiscal Year: 2002..abstract_text> ..
- GENE EXPRESSION BASED CLASSIFICATION OF GLIAL TUMORSStanley Nelson; Fiscal Year: 2004..3)To develop a set of genes with prognostic importance in low grade astrocytomas. 4)To validate the importance of the genes from specific aims 2 and 3 in the prognosis of low grade astrocytomas. ..
- MECHANISMS REGULATING UTERINE MORPHOGENESISThomas Spencer; Fiscal Year: 2004....
- DETERMINANTS OF TISSUE ESTRADIOL SENSITIVITYRichard Santen; Fiscal Year: 2009..FTS, a novel mTOR inhibitor will be used in vitro to activate the stress kinase pathway and apoptosis. In vivo, FTS will be used to enhance estradiol induced apoptosis in nude mice. ..
- Biology at the Maternal-Fetal InterfaceMichael Soares; Fiscal Year: 2006..The overall goal of the program project is to understand regulatory processes that will lead to the development of therapeutic strategies for the purpose of improving the quality and success of pregnancy. ..
- 4-Hydroxyestradiol Receptor in Breast CancerJose Russo; Fiscal Year: 2005..This plan is in line with goals 1 and 3 of the Breast Cancer Progress Review Group to better understand the biology of the normal mammary gland and of precancerous lesions. ..
- Case-Control Study of Pancreas Cancer Etiologic FactorsHarvey Risch; Fiscal Year: 2008..The factors to be examined here have received little attention with respect to pancreas cancer, and the proposed study will evaluate them systematically in a vigorous, large-scale and integrated project. [unreadable] [unreadable]..
- Genetic Regulation of Postnatal Uterine Morphogenesis and FunctionThomas Spencer; Fiscal Year: 2008..ablate Wnt7a in the epithelium of the uterus after birth using the Cre/LoxP system and the innovative progesterone receptor-Cre knockin mouse model...
- Hormones, hormone-related genes, and colorectal cancerJennifer Lin; Fiscal Year: 2008..aromatase cytochrome P450 gene (CYP19A1), estrogen receptor alpha (ESR1), estrogen receptor beta (ESR2), progesterone receptor (PGR) and CRC risk...
- Society of Gynecologic Investigation Annual MeetingAndrew Berchuck; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- UCLA NHLBI Shared Microarray FacilitiesStanley Nelson; Fiscal Year: 2005..As large scale data handling and processing can be a daunting task for biologists, we propose to provide dedicated expert data managing and statistical assistance. ..
- PROGESTERONE RECEPTOR A AND B PROTEINS IN REPRODUCTIONORLA CONNEELY; Fiscal Year: 2008..abstract_text> ..
- P13K/AKT crosstalk with ER-signaling and cell survivalMatthew Burow; Fiscal Year: 2008..This cross-talk and the mechanisms identified will be used to establish the biological relevancy of the pathway in terms of cell survival and altered SERM activity. ..
- THE MAJOR ANGIOGENIC FACTORS IN PLACENTAL ANGIOGENESISLawrence Reynolds; Fiscal Year: 2004..abstract_text> ..
- Physiological Genomics of PregnancyMichael Soares; Fiscal Year: 2007..The proposed analysis should lead to effective strategies for identifying genes implicated in diseases leading to pregnancy failure. [unreadable] [unreadable] [unreadable]..
- Genomic Basis of Reproductive History on Breast CancerJose Russo; Fiscal Year: 2006..abstract_text> ..
- Oncogenes and loss of ER in a new p53 breast tumor modelEva Lee; Fiscal Year: 2006..These proposed studies should provide significant insights into molecular events involved in breast cancer progression and critical information for anti-estrogen based breast cancer prevention and intervention. ..