progesterone receptor

Summary

Gene Symbol: progesterone receptor
Description: progesterone receptor
Alias: NR3C3, progesterone receptor, nuclear receptor subfamily 3 group C member 3
Species: human

Top Publications

  1. pmc Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B
    P Kastner
    Laboratoire de Genetique Moleculaire des Eucaryotes, CNRS, Strasbourg, France
    EMBO J 9:1603-14. 1990
  2. ncbi Analysis of the human progesterone receptor gene polymorphism progins in Austrian ovarian carcinoma patients
    D Tong
    Department of Obstetrics and Gynecology, Division of Gynecology, General Hospital of Vienna, University of Vienna, Vienna, Austria
    Int J Cancer 95:394-7. 2001
  3. ncbi Distinct functional differences of human progesterone receptors A and B on gene expression and growth regulation in two endometrial carcinoma cell lines
    Ellen Smid-Koopman
    Department of Obstetrics and Gynaecology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Soc Gynecol Investig 10:49-57. 2003
  4. ncbi The multiple promoter methylation profile of PR gene and ERalpha gene in tumor cell lines
    Ze Jun Liu
    Department of Laboratory Medicine, Hamamatsu University School of Medicine, Hamamatsu 431 3192, Japan
    Life Sci 73:1963-72. 2003
  5. ncbi Subnuclear distribution of progesterone receptors A and B in normal and malignant endometrium
    Rebecca L Arnett-Mansfield
    Westmead Institute for Cancer Research, University of Sydney at the Westmead Millennium Institute, NSW, Australia
    J Clin Endocrinol Metab 89:1429-42. 2004
  6. ncbi Phosphorylation-dependent antagonism of sumoylation derepresses progesterone receptor action in breast cancer cells
    Andrea R Daniel
    Department of Medicine Division of Hematology, Oncology, and Transplantation, University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
    Mol Endocrinol 21:2890-906. 2007
  7. ncbi Promoter hypermethylation of TMS1, BRCA1, ERalpha and PRB in serum and tumor DNA of invasive ductal breast carcinoma patients
    Sameer Mirza
    Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    Life Sci 81:280-7. 2007
  8. doi Progesterone receptor is a significant factor associated with clinical outcomes and effect of adjuvant tamoxifen therapy in breast cancer patients
    Shuzhen Liu
    Genetic Pathology Evaluation Centre at Vancouver General Hospital, Prostate Center, University of British Columbia, Vancouver, BC, Canada
    Breast Cancer Res Treat 119:53-61. 2010
  9. pmc Protein kinases mediate ligand-independent derepression of sumoylated progesterone receptors in breast cancer cells
    Andrea R Daniel
    Department of Medicine, Division of Hematology, University of Minnesota Masonic Cancer Center, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 106:14287-92. 2009
  10. pmc The progesterone receptor hinge region regulates the kinetics of transcriptional responses through acetylation, phosphorylation, and nuclear retention
    Andrea R Daniel
    University of Minnesota Cancer Center, 420 Delaware Street SE, MMC 806, Minneapolis, Minnesota 55455, USA
    Mol Endocrinol 24:2126-38. 2010

Research Grants

  1. Michael J Soares; Fiscal Year: 2014
  2. Richard L Stouffer; Fiscal Year: 2015
  3. Ruth Lupu; Fiscal Year: 2014
  4. ESTROGENIC REGULATION OF MAMMARY PROGESTERONE RECEPTORS
    G Shyamala; Fiscal Year: 1990
  5. Flaxseed vs. aromatase inhibitors: breast tumor characteristics and prognosis
    Susan McCann; Fiscal Year: 2009
  6. Dietary lignan effects on hormone, growth, and signaling factors in breast tumors
    Susan McCann; Fiscal Year: 2009
  7. MECHANISM OF HORMONAL CONTROL OF MAMMARY CARCINOMA
    Suzanne Fuqua; Fiscal Year: 1993
  8. MECHANISM OF HORMONAL CONTROL OF MAMMARY CARCINOMA
    WILLIAM MC GUIRE; Fiscal Year: 1992
  9. Development and validation of predictors of endocrine treatment sensitivity
    Christos Hatzis; Fiscal Year: 2007
  10. Estrogen and Progesterone-related Gene Variants and Colorectal Cancer Risk
    Shumin Zhang; Fiscal Year: 2009

Detail Information

Publications274 found, 100 shown here

  1. pmc Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B
    P Kastner
    Laboratoire de Genetique Moleculaire des Eucaryotes, CNRS, Strasbourg, France
    EMBO J 9:1603-14. 1990
    The human progesterone receptor (hPR) cDNA, synthesized from T47D breast cancer cells, and the hPR gene 5'-flanking region were cloned and sequenced...
  2. ncbi Analysis of the human progesterone receptor gene polymorphism progins in Austrian ovarian carcinoma patients
    D Tong
    Department of Obstetrics and Gynecology, Division of Gynecology, General Hospital of Vienna, University of Vienna, Vienna, Austria
    Int J Cancer 95:394-7. 2001
    ..A polymorphism in intron G of the human progesterone receptor (PgR), caused by an Alu insertion, was described to be associated with ovarian carcinoma in a pooled ..
  3. ncbi Distinct functional differences of human progesterone receptors A and B on gene expression and growth regulation in two endometrial carcinoma cell lines
    Ellen Smid-Koopman
    Department of Obstetrics and Gynaecology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Soc Gynecol Investig 10:49-57. 2003
    To study the functional differences between the two progesterone receptor isoforms (hPRA and hPRB) in human endometrial cancer, two new endometrial carcinoma cell lines were created-one expressing hPRA and one expressing hPRB...
  4. ncbi The multiple promoter methylation profile of PR gene and ERalpha gene in tumor cell lines
    Ze Jun Liu
    Department of Laboratory Medicine, Hamamatsu University School of Medicine, Hamamatsu 431 3192, Japan
    Life Sci 73:1963-72. 2003
    ..PCR (MSP) assay method, we observed alterations in DNA methylation at the double promoter regions of the progesterone receptor (PR) gene and estrogen receptor (ERalpha) gene in various tumor cell lines...
  5. ncbi Subnuclear distribution of progesterone receptors A and B in normal and malignant endometrium
    Rebecca L Arnett-Mansfield
    Westmead Institute for Cancer Research, University of Sydney at the Westmead Millennium Institute, NSW, Australia
    J Clin Endocrinol Metab 89:1429-42. 2004
    The nuclear progesterone receptor (PR), which is expressed as two proteins with different functions (PRA and PRB), is expressed in the normal endometrium and endometrial cancer...
  6. ncbi Phosphorylation-dependent antagonism of sumoylation derepresses progesterone receptor action in breast cancer cells
    Andrea R Daniel
    Department of Medicine Division of Hematology, Oncology, and Transplantation, University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
    Mol Endocrinol 21:2890-906. 2007
    ..In the context of elevated protein kinase activities, such as during mammary gland development or breast cancer progression, phosphorylated PR-B may be undersumoylated, transcriptionally hyperactive, and unstable/undetectable...
  7. ncbi Promoter hypermethylation of TMS1, BRCA1, ERalpha and PRB in serum and tumor DNA of invasive ductal breast carcinoma patients
    Sameer Mirza
    Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    Life Sci 81:280-7. 2007
    ..This study also underscores the potential utility of DNA methylation based screening of serum (a surrogate for tumor DNA methylation) as a tool for detection of breast cancer...
  8. doi Progesterone receptor is a significant factor associated with clinical outcomes and effect of adjuvant tamoxifen therapy in breast cancer patients
    Shuzhen Liu
    Genetic Pathology Evaluation Centre at Vancouver General Hospital, Prostate Center, University of British Columbia, Vancouver, BC, Canada
    Breast Cancer Res Treat 119:53-61. 2010
    ..The additional value of progesterone receptor (PR) has remained controversial...
  9. pmc Protein kinases mediate ligand-independent derepression of sumoylated progesterone receptors in breast cancer cells
    Andrea R Daniel
    Department of Medicine, Division of Hematology, University of Minnesota Masonic Cancer Center, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 106:14287-92. 2009
    ..Herein, we explored mechanisms of ligand-independent progesterone receptor (PR) activity...
  10. pmc The progesterone receptor hinge region regulates the kinetics of transcriptional responses through acetylation, phosphorylation, and nuclear retention
    Andrea R Daniel
    University of Minnesota Cancer Center, 420 Delaware Street SE, MMC 806, Minneapolis, Minnesota 55455, USA
    Mol Endocrinol 24:2126-38. 2010
    ..In sum, the PR hinge region is multifunctional. Understanding the ability of this region to couple acetylation, phosphorylation, and nuclear entry may provide clues to mechanisms of altered hormone responsiveness...
  11. ncbi Sequence and characterization of a coactivator for the steroid hormone receptor superfamily
    S A Onate
    Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Science 270:1354-7. 1995
    A yeast two-hybrid system was used to identify a protein that interacts with and enhances the human progesterone receptor (hPR) transcriptional activity without altering the basal activity of the promoter...
  12. ncbi Progesterone receptor polymorphisms and risk of breast cancer: results from two Australian breast cancer studies
    Sharon E Johnatty
    Cancer and Cell Biology, Queensland Institute of Medical Research, c o Royal Brisbane Hospital Post Office, Herston, Brisbane, QLD, 4029, Australia
    Breast Cancer Res Treat 109:91-9. 2008
    Association studies aimed at identifying breast cancer susceptibility variants in the progesterone receptor (PGR) gene have been previously reported in the literature with conflicting results, ranging from a protective effect conferred ..
  13. pmc ck2-dependent phosphorylation of progesterone receptors (PR) on Ser81 regulates PR-B isoform-specific target gene expression in breast cancer cells
    Christy R Hagan
    Department of Medicine and Women s Cancer Program, University of Minnesota, Minneapolis, Minnesota, USA
    Mol Cell Biol 31:2439-52. 2011
    ....
  14. doi Evaluation of a hormone receptor-positive ovarian carcinoma subtype with a favourable prognosis by determination of progesterone receptor and oestrogen receptor 1 mRNA expression in formalin-fixed paraffin-embedded tissue
    Bruno V Sinn
    Institute of Pathology, Charite Universitatsmedizin Berlin, Germany
    Histopathology 59:918-27. 2011
    ..The aim of this study was to examine the prognostic role of progesterone receptor (PR) protein and mRNA expression.
  15. pmc Nuclear factor 1 synergizes with progesterone receptor on the mouse mammary tumor virus promoter wrapped around a histone H3/H4 tetramer by facilitating access to the central hormone-responsive elements
    Guillermo Pablo Vicent
    Centre de Regulacio Genomica, Universitat Pompeu Fabra, Parc de Recerca Biomedica, Dr Aiguader 88, E 08003 Barcelona, Spain
    J Biol Chem 285:2622-31. 2010
    ..mammary tumor virus (MMTV) promoter progesterone induction is mediated by the reciprocal synergism between progesterone receptor (PR) and the ubiquitous transcription factor nuclear factor 1 (NF1)...
  16. pmc Cyclin-dependent kinase activity is required for progesterone receptor function: novel role for cyclin A/Cdk2 as a progesterone receptor coactivator
    Ramesh Narayanan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Biol 25:264-77. 2005
    Our studies examining the role of the cell cycle-regulated kinase cyclin A/Cdk2 in progesterone receptor (PR) action have demonstrated that cyclin-dependent kinase activity is required for PR function and that cyclin A/Cdk2 functions as ..
  17. pmc Progesterone receptor rapid signaling mediates serine 345 phosphorylation and tethering to specificity protein 1 transcription factors
    Emily J Faivre
    Department of Medicine, Division of Hematology, Oncology, and Transplantation, University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
    Mol Endocrinol 22:823-37. 2008
    ..Our data demonstrate the therapeutic potential for PR-targeted breast cancer treatment by exploiting multiple nodes along the PR signaling pathway, including PR-B, EGFR, c-Src, MAPK, or Sp1...
  18. pmc Accumulation of uPA-PAI-1 complexes inside the tumour cells is associated with axillary nodal invasion in progesterone-receptor-positive early breast cancer
    J Schneider
    Fundación Tejerina Centro de Patología de la Mama, Madrid, Spain
    Br J Cancer 88:96-101. 2003
    ..we found a statistically significant interaction between the presence of uPA-PAI-1 complexes and progesterone receptor positivity (P=0.04)...
  19. ncbi Repressors of androgen and progesterone receptor action
    Irina U Agoulnik
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 278:31136-48. 2003
    ..We found that although DAX-1 is expressed in normal human prostate, its expression is strongly reduced in benign prostatic hyperplasia suggesting that DAX-1 plays a role in limiting AR activity in prostate...
  20. ncbi No association between the progesterone receptor gene +331G/A polymorphism and breast cancer
    Heather Spencer Feigelson
    Department of Epidemiology and Surveillance Research, American Cancer Society, 1599 Clifton Road NE, Atlanta GA 30309, USA
    Cancer Epidemiol Biomarkers Prev 13:1084-5. 2004
  21. ncbi Estrogen and progesterone receptor gene polymorphisms and sporadic breast cancer risk: a Spanish case-control study
    L P Fernandez
    Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Centre CNIO, Madrid, Spain
    Int J Cancer 119:467-71. 2006
    ..Our results obtained in a European population confirm the protective role of the S10S variant in ESR1, previously reported in an Asian and a European-American population...
  22. doi Low activation of Insulin-like Growth Factor 1-Receptor (IGF1R) is associated with local recurrence in early breast carcinoma
    Gloria Peiro
    Research Unit, Hospital General Universitari d Alacant, c Pintor Baeza s n, 03010 Alacant, Spain
    Breast Cancer Res Treat 117:433-41. 2009
    ..Therefore, do not benefit from a boost dose on the surgical scar...
  23. pmc Oncoprotein HCCR-1 expression in breast cancer is well correlated with known breast cancer prognostic factors including the HER2 overexpression, p53 mutation, and ER/PR status
    Seon Ah Ha
    Department of Molecular Genetic Laboratory, College of Medicine, The Catholic University of Korea, Seoul, Korea
    BMC Cancer 9:51. 2009
    ..The serum HCCR-1 assay is useful in diagnosing breast cancer and mice transgenic for HCCR developed breast cancers. But it is unknown how HCCR-1 contributes to human breast tumorigenesis...
  24. pmc +331G/A variant in the progesterone receptor gene, postmenopausal hormone use and risk of breast cancer
    Joanne Kotsopoulos
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Cancer 125:1685-91. 2009
    A functional promoter polymorphism in the progesterone receptor (PR) gene previously has been associated with an increased risk of postmenopausal breast cancer...
  25. pmc Genetic variation in the progesterone receptor gene and risk of endometrial cancer: a haplotype-based approach
    Eunjung Lee
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90089, USA
    Carcinogenesis 31:1392-9. 2010
    ..The PROGINS allele of the progesterone receptor (PGR) gene reduces the function of PGR and has been associated with increased risk of the endometrioid ..
  26. doi Polymorphisms in VEGF, progesterone receptor and IL-1 receptor genes in women with recurrent spontaneous abortion
    Evelyn Traina
    Obstetrics Departament, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    J Reprod Immunol 88:53-7. 2011
    ..Here we investigate the relationship between RSA and gene polymorphisms of the progesterone receptor (PROGINS), interleukin-1 receptor 1 (PstI) and vascular endothelial growth factor (VEGF) (-634, 936)...
  27. ncbi The inhibitory function in human progesterone receptor N termini binds SUMO-1 protein to regulate autoinhibition and transrepression
    Hany Abdel-Hafiz
    Department of Medicine, Molecular Biology Program, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    J Biol Chem 277:33950-6. 2002
    ..We conclude that autoinhibition and transrepression involve N-terminal sumoylation combined with intramolecular N/C-terminal communication...
  28. ncbi Progesterone receptor modulator CDB-2914 down-regulates proliferative cell nuclear antigen and Bcl-2 protein expression and up-regulates caspase-3 and poly(adenosine 5'-diphosphate-ribose) polymerase expression in cultured human uterine leiomyoma cells
    Qin Xu
    Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Chuo Ku, Kobe 650 0017, Japan
    J Clin Endocrinol Metab 90:953-61. 2005
    The present study was conducted to evaluate the effects of the progesterone receptor modulator CDB-2914 on proliferative activity and apoptosis in cultured human uterine leiomyoma cells...
  29. pmc Cooperative activation of cyclin D1 and progesterone receptor gene expression by the SRC-3 coactivator and SMRT corepressor
    Sudipan Karmakar
    Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 24:1187-202. 2010
    ..cancer cells, and we report herein the E2-dependent recruitment of SMRT to the regulatory regions of the progesterone receptor (PR) and cyclin D1 genes...
  30. doi Prokineticin 1, homeobox A10, and progesterone receptor messenger ribonucleic acid expression in primary cultures of endometrial stromal cells isolated from endometrium of healthy women and from eutopic endometrium of women with endometriosis
    Federica Tiberi
    Istituto Scientifico Internazionale Paolo VI, Università Cattolica del Sacro Cuore UCSC, Rome, Italy
    Fertil Steril 94:2558-63. 2010
    ....
  31. ncbi Estrogen and progesterone receptor subtype expression in normal and malignant ovarian epithelial cell cultures
    Andrew J Li
    Department of Obstetrics and Gynecology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Am J Obstet Gynecol 189:22-7. 2003
    ..Epidemiologic data suggest that the malignant transformation of ovarian epithelium may be linked to altered steroid hormone homeostasis...
  32. ncbi Progesterone receptors (PR)-B and -A regulate transcription by different mechanisms: AF-3 exerts regulatory control over coactivator binding to PR-B
    Lin Tung
    Department of Medicine, RC1 South, 12801 East 17th Avenue, P O Box 6511, Aurora, Colorado 80045, USA
    Mol Endocrinol 20:2656-70. 2006
    ..In sum, AF3 in BUS plays a critical modulatory role in PR-B, and in doing so, defines a mechanism for PR-B function that is fundamentally distinct from that of PR-A...
  33. pmc Estrogens and progesterone promote persistent CCND1 gene activation during G1 by inducing transcriptional derepression via c-Jun/c-Fos/estrogen receptor (progesterone receptor) complex assembly to a distal regulatory element and recruitment of cyclin D1 t
    Luigi Cicatiello
    Dipartimento di Patologia Generale, Seconda Universita degli Studi di Napoli, 80138 Naples, Italy
    Mol Cell Biol 24:7260-74. 2004
    ....
  34. ncbi Negative interaction between the RelA(p65) subunit of NF-kappaB and the progesterone receptor
    E Kalkhoven
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht
    J Biol Chem 271:6217-24. 1996
    ..describes the mutual repression of two transcription factors, the RelA(p65) subunit of NF-kappaB and the progesterone receptor (PR)...
  35. ncbi p27KIP-1, cyclin A and cyclin D1 protein expression in ductal carcinoma in situ of the breast: p27KIP-1 correlates with hormone receptor status but not with local recurrence
    Ewan K A Millar
    Department of Anatomical Pathology, South Eastern Area Laboratory Service, St George Hospital, NSW, Australia
    Pathol Int 57:183-9. 2007
    ..There was a highly significant positive association between p27(KIP-1) and estrogen receptor/progesterone receptor (ER/PR) status (P = 0.002, P = 0.02) and with p27(KIP-1) and cyclin D1 expression (P = 0.002)...
  36. ncbi Coactivator assembly at the promoter: efficient recruitment of SRC2 is coupled to cooperative DNA binding by the progesterone receptor
    Aaron F Heneghan
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, Colorado 80262, USA
    Biochemistry 46:11023-32. 2007
    ..We have previously resolved the microstate interaction energetics of progesterone receptor A-isoform (PR-A) assembly at multiple promoters; here we extend this work to the role of PR-A in mediating ..
  37. pmc Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26S proteasome
    C A Lange
    Department of Medicine, The Molecular Biology Program, and The Colorado Cancer Center, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 97:1032-7. 2000
    ..Specifically, down-regulation of mature PRs occurs by a mechanism in which ligand binding activates PR phosphorylation by MAPKs at a unique serine residue, which then targets the receptors for degradation...
  38. ncbi ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional activation
    N Kotaja
    Department of Physiology, Institute of Biomedicine, University of Helsinki, Finland
    Mol Endocrinol 14:1986-2000. 2000
    ..more efficiently than Miz1 or PIAS1, and all PIAS proteins also activate estrogen receptor- and progesterone receptor-dependent transcription but to a dissimilar degree...
  39. pmc Genetic variation in the progesterone receptor gene and ovarian cancer risk
    Kathryn L Terry
    Obstetrics and Gynecology Epidemiology Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Epidemiol 161:442-51. 2005
    ..Thus, genetic variations that may cause alterations in the biologic functions of the progesterone receptor can potentially contribute to individual susceptibility to ovarian cancer...
  40. ncbi Up-regulation of the progesterone receptor (PR)-C isoform in laboring myometrium by activation of nuclear factor-kappaB may contribute to the onset of labor through inhibition of PR function
    Jennifer C Condon
    Department of Biochemistry, North Texas March of Dimes Birth Defects Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9038, USA
    Mol Endocrinol 20:764-75. 2006
    Progesterone acting via the progesterone receptor (PR) plays a critical role in maintaining uterine quiescence during pregnancy...
  41. ncbi Induction of progesterone target genes requires activation of Erk and Msk kinases and phosphorylation of histone H3
    Guillermo P Vicent
    Centre de Regulacio Genomica, Universitat Pompeu Fabra, Parc de Recerca Biomedica, Dr Aiguader 88, E 08003 Barcelona, Spain
    Mol Cell 24:367-81. 2006
    ..Five minutes after hormone treatment, Erk activation leads to phosphorylation of the progesterone receptor (PR), activation of Msk1, and recruitment of a complex of the three proteins to a nucleosome on the MMTV ..
  42. pmc High-mobility group chromatin proteins 1 and 2 functionally interact with steroid hormone receptors to enhance their DNA binding in vitro and transcriptional activity in mammalian cells
    V Boonyaratanakornkit
    Department of Pathology and Molecular Biology Program, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Mol Cell Biol 18:4471-87. 1998
    ..the chromatin high-mobility group protein 1 (HMG-1) enhances the sequence-specific DNA binding activity of progesterone receptor (PR) in vitro, thus providing the first evidence that HMG-1 may have a coregulatory role in steroid ..
  43. pmc The Angelman syndrome-associated protein, E6-AP, is a coactivator for the nuclear hormone receptor superfamily
    Z Nawaz
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cell Biol 19:1182-9. 1999
    ..protein (E6-AP/UBE3A) directly interacts with and coactivates the transcriptional activity of the human progesterone receptor (PR) in a hormone-dependent manner...
  44. ncbi PROGINS receptor gene polymorphism is associated with endometriosis
    Fritz Wieser
    Department of Obstetrics and Gynecology, Division of Gynecological Endocrinology and Reproductive Medicine, University of Vienna, Waeringer Guertel 18 20, A 1090 Vienna, Austria
    Fertil Steril 77:309-12. 2002
    To investigate the association between the 306-base pair insertion polymorphism in intron G of the progesterone receptor (PROGINS) and endometriosis.
  45. ncbi Decreased progesterone receptor expression in the intermediate trophoblastic cells of spontaneous abortions
    Timothy N Hickman
    Department of Gynecology and Obstetrics, Division of Reproductive Endocrinology and Infertility, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Fertil Steril 77:1001-5. 2002
    To determine whether there are differences in the expression of progesterone receptor (PR) in intermediate trophoblastic cells of pregnancies ending in either spontaneous abortion (SAB) or elective abortion.
  46. ncbi New human breast cancer cells to study progesterone receptor isoform ratio effects and ligand-independent gene regulation
    Britta M Jacobsen
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 277:27793-800. 2002
    All known progesterone target cells coexpress two functionally different progesterone receptor (PR) isoforms: 120-kDa B-receptors (PR-B) and N-terminally truncated, 94-kDa A-receptors (PR-A)...
  47. ncbi Progesterone receptor activates its promoter activity in human endometrial stromal cells
    Meiyi Tang
    Department of Obstetrics Gynecology and Reproductive Medicine, School of Medicine, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
    Mol Cell Endocrinol 192:45-53. 2002
    Previous studies have shown that progestin increases the content of progesterone receptor (hPRA and hPRB) and the hPR mRNA during decidualization of human endometrial stromal cells suggesting that endogenous hPR enhances the ..
  48. ncbi Immunohistochemical analysis of 1,25-dihydroxyvitamin-D3-receptors, estrogen and progesterone receptors and Ki-67 in ovarian carcinoma
    Carlos Villena-Heinsen
    Department of Gynecology, University of Saarland, Homburg, Germany
    Anticancer Res 22:2261-7. 2002
    ..The aim of this study was to analyze immunohistochemically the expression of VDR in normal and carcinomatous ovarian tissue to evaluate whether ovarian tissue may be a new potential target for biologically active vitamin D analogues...
  49. ncbi Sumoylation of the progesterone receptor and of the steroid receptor coactivator SRC-1
    Anne Chauchereau
    INSERM U135, Hormones, Genes, and Reproduction, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre, France
    J Biol Chem 278:12335-43. 2003
    ..We show here that SUMO-1 overexpression markedly enhances progesterone receptor (PR)-mediated gene transcription...
  50. ncbi Insulin-like growth factor-I inhibits progesterone receptor expression in breast cancer cells via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway: progesterone receptor as a potential indicator of growth factor activity in brea
    Xiaojiang Cui
    Breast Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 17:575-88. 2003
    ..In this study, we found that IGF-I sharply lowers progesterone receptor (PR) mRNA and protein levels in breast cancer cells...
  51. ncbi Novel isoforms of the mRNA for human female sex steroid hormone receptors
    Shuji Hirata
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Yamanashi, Shimokato 1110, Tamaho, Nakakoma, Yamanashi 409 3898, Japan
    J Steroid Biochem Mol Biol 83:25-30. 2002
    ..In the present communication, our recent data along with others on the novel isoform/variant mRNAs for the human female sex steroid hormone receptors will be summarized...
  52. ncbi Novel alternatively spliced variant with a deletion of 52 BP in exon 6 of the progesterone receptor gene is observed frequently in breast cancer tissues
    Hisashi Hisatomi
    Center for Molecular Biology and Cytogenetics, SRL Inc, Tokyo, Japan
    Int J Cancer 105:182-5. 2003
    The human progesterone receptor (PR) is a ligand-activated nuclear transcription factor that mediates progesterone action in target tissues. We found a novel alternatively spliced variant (ASV) of the PR mRNA in breast cancer tissues...
  53. ncbi Human progesterone receptor polymorphisms and implantation failure during in vitro fertilization
    Daniel W Cramer
    Department of Obstetrics, Gynecology and Reproductive Biology, Ob Gyn Epidemiology Center, 221 Longwood Avenue, Brigham and Women s Hospital, Boston, MA, USA
    Am J Obstet Gynecol 189:1085-92. 2003
    Polymorphic variants of the human progesterone receptor gene have been described, but their potential influence on in vitro fertilization outcome have not been studied.
  54. ncbi Fos and Jun inhibit estrogen-induced transcription of the human progesterone receptor gene through an activator protein-1 site
    Larry N Petz
    Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, 524 Burrill Hall, 407 South Goodwin Avenue, Urbana, Illinois 61801, USA
    Mol Endocrinol 18:521-32. 2004
    The progesterone receptor (PR) gene is activated by estrogen in normal reproductive tissues and in MCF-7 human breast cancer cells...
  55. pmc Molecular chaperones function as steroid receptor nuclear mobility factors
    Cem Elbi
    Laboratory of Receptor Biology and Gene Expression, Building 41, Room B602, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 5055, USA
    Proc Natl Acad Sci U S A 101:2876-81. 2004
    ..Thus, our results provide a description of soluble nuclear mobility factors and furthermore demonstrate a previously unrecognized role for molecular chaperones in the regulation of steroid receptor function within the nucleus...
  56. ncbi Transcriptional cross talk between the forkhead transcription factor forkhead box O1A and the progesterone receptor coordinates cell cycle regulation and differentiation in human endometrial stromal cells
    Masashi Takano
    Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, United Kingdom
    Mol Endocrinol 21:2334-49. 2007
    ..Using a glutathione-S-transferase pull-down assay, we confirmed that FOXO1 interacts with progesterone receptor, irrespectively of the presence of ligand...
  57. doi Single nucleotide polymorphisms in the human progesterone receptor gene and spontaneous preterm birth
    - Guoyang Luo
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA
    Reprod Sci 15:147-55. 2008
    Progesterone supplementation can prevent preterm birth in some high-risk women. Progesterone binds to progesterone receptor (PR) and modulates the expression of target genes...
  58. pmc The human progesterone receptor shows evidence of adaptive evolution associated with its ability to act as a transcription factor
    Caoyi Chen
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Mol Phylogenet Evol 47:637-49. 2008
    The gene encoding the progesterone receptor (PGR) acts as a transcription factor, and participates in the regulation of reproductive processes including menstruation, implantation, pregnancy maintenance, parturition, mammary development, ..
  59. doi Systematic expression analysis and antibody screening do not support the existence of naturally occurring progesterone receptor (PR)-C, PR-M, or other truncated PR isoforms
    Annemarie Samalecos
    Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany
    Endocrinology 149:5872-87. 2008
    ..Thus, the 60-kDa protein called PR-C does not originate from AUG-595 and is not a naturally occurring PR isoform...
  60. doi Comparing expression of progesterone and estrogen receptors in testicular tissue from men with obstructive and nonobstructive azoospermia
    Yibing Han
    Department of Obstetrics and Gynaecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, SAR, China
    J Androl 30:127-33. 2009
    The objective of this study was to identify and compare the expression profiles of progesterone receptor (PR) and estrogen receptor alpha (ERalpha) in the testes of men with obstructive azoospermia (OA), maturation arrest (MA), and ..
  61. ncbi Progesterone receptor variants found in breast cells repress transcription by wild-type receptors
    J K Richer
    Department of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    Breast Cancer Res Treat 48:231-41. 1998
    ..We propose that expression of variant PR can compromise the accuracy of receptor measurements as markers of hormone-dependent cancers, and can modify the responses of tumors to progestin therapies...
  62. ncbi Variant estrogen and progesterone receptor messages in human vascular smooth muscle
    Y K Hodges
    Department of Medicine, Division of Cardiology, University of Colorado Health Sciences Center, Denver, Colo 80262, USA
    Circulation 99:2688-93. 1999
    ..Therefore, we analyzed the structure of estrogen receptors (ERs) and progesterone receptors (PRs) in human vascular smooth muscle...
  63. pmc The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding
    P H Giangrande
    Department of Pharmacology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell Biol 20:3102-15. 2000
    The human progesterone receptor (PR) exists as two functionally distinct isoforms, hPRA and hPRB...
  64. ncbi Ligand-activated progesterone receptor isoform hPR-A is a stronger transactivator than hPR-B for the expression of IGFBP-1 (insulin-like growth factor binding protein-1) in human endometrial stromal cells
    J Gao
    Department of Obstetrics Gynecology and Reproductive Medicine, School of Medicine, State University of New York at Stony Brook, 11794, USA
    Mol Endocrinol 14:1954-61. 2000
    In human endometrium, the levels of progesterone receptor (PR) isoforms hPR-A and hPR-B are differentially regulated during the reproductive cycle...
  65. ncbi Progesterone receptor contains a proline-rich motif that directly interacts with SH3 domains and activates c-Src family tyrosine kinases
    V Boonyaratanakornkit
    University of Colorado School of Medicine, Pathology Department and Molecular Biology Program, Denver, CO 80262, USA
    Mol Cell 8:269-80. 2001
    ..We have identified a specific polyproline motif in the amino-terminal domain of conventional progesterone receptor (PR) that mediates direct progestin-dependent interaction of PR with SH3 domains of various cytoplasmic ..
  66. ncbi Differential gene regulation by the two progesterone receptor isoforms in human breast cancer cells
    Jennifer K Richer
    Department of Medicine Endocrinology, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    J Biol Chem 277:5209-18. 2002
    ..Additionally, use of natural target genes, rather than "consensus" response elements, for transcription studies should improve our understanding of steroid hormone action...
  67. ncbi The novel exon, exon T, of the human progesterone receptor gene and the genomic organization of the gene
    Shuji Hirata
    Department of Obstetrics and Gynecology, Yamanashi Medical University, Shimokato 1110, Tamaho, Nakakoma 409 3898, Japan
    J Steroid Biochem Mol Biol 80:365-7. 2002
    Recently, we have cloned the novel isoform of the progesterone receptor (PR) cDNA (PR isoform S cDNA) from the human testicular cDNA library...
  68. ncbi The progesterone receptor exon 4 Val660Leu G/T polymorphism and risk of breast cancer in Australian women
    Amanda B Spurdle
    Oncology Division, Joint Experimental Oncology Programme, The Queensland Institute of Medical Research, and The University of Queensland, Brisbane, 4029, Australia
    Cancer Epidemiol Biomarkers Prev 11:439-43. 2002
    An Alu insertion polymorphism of the progesterone receptor (PR) wasreported recently to be associated with a reduced risk of breast cancer, with risks of 0.8- and 0...
  69. ncbi Human progesterone receptor gene polymorphism PROGINS and risk for breast cancer in Austrian women
    Gerhild Fabjani
    Department of Obstetrics and Gynecology, General Hospital of Vienna, University of Vienna
    Breast Cancer Res Treat 72:131-7. 2002
    A germline TaqI restriction fragment length polymorphism in the intron G of the progesterone receptor (PR) gene designated PROGINS was described to be associated with an increased risk for ovarian carcinoma...
  70. ncbi Differential expression of progesterone receptor isoforms A and B in the normal ovary, and in benign, borderline, and malignant ovarian tumors
    Jun ichi Akahira
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Aoba ku, Sendai 980 8574, Japan
    Jpn J Cancer Res 93:807-15. 2002
    ..In this study, we examined the differential expression patterns of the two progesterone receptor (PR) isoforms, PRA and PRB, using immunohistochemistry and real-time quantitative RT-PCR in normal and ..
  71. pmc A functional polymorphism in the promoter of the progesterone receptor gene associated with endometrial cancer risk
    Immaculata De Vivo
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:12263-8. 2002
    ..Because the antiproliferative effect of progesterone requires the progesterone receptor (PR), which exists in two isoforms, PR-A and -B, we reasoned that variants in the PR gene may predispose ..
  72. ncbi Progesterone receptor mRNA variant containing novel exon insertions between exon 4 and exon 5 in human uterine endometrium
    Tomoya Yamanaka
    Department of Obstetrics and Gynecology, Yamanashi Medical University, Tamaho, Nakakoma, Japan
    Endocr J 49:473-82. 2002
    The presence of human progesterone receptor (PR) mRNA variants has been demonstrated in uterine endometrium and breast tissues as well as in cancer cells of these tissues...
  73. ncbi Estrogen receptor alpha and activating protein-1 mediate estrogen responsiveness of the progesterone receptor gene in MCF-7 breast cancer cells
    Larry N Petz
    Department of Molecular and Integrative Physiology, University of Illinois, Urbana, Illinois 61801, USA
    Endocrinology 143:4583-91. 2002
    The progesterone receptor (PR) gene is activated by estrogen in MCF-7 human breast cancer cells...
  74. ncbi Cyclic changes in the expression of steroid receptor coactivators and corepressors in the normal human endometrium
    Tanri Shiozawa
    Department of Obstetrics and Gynecology, Shinshu University School of Medicine, Matsumoto 390 8621, Japan
    J Clin Endocrinol Metab 88:871-8. 2003
    ..Cyclic change in the expression of SRC-1 during the menstrual cycle might be important in the estrogen-action for the glandular and stromal cells...
  75. ncbi Expression of a novel splicing variant deleting exons 4 and 6 of the progesterone receptor gene is a rare event in breast cancer
    Kumi Nagao
    Center for Molecular Biology and Cytogenetics, SRL, Inc, Tokyo 191 0002, Japan
    Oncol Rep 10:305-8. 2003
    ..The expressions of ASVs that induced the mimic PR transcripts need to be considered when designing strategies for regulation analysis of the PR gene...
  76. ncbi Cloning and expression of a novel, truncated, progesterone receptor
    Karla J Saner
    Department of Microbiology and Molecular Medicine, Clemson University, SC, USA
    Mol Cell Endocrinol 200:155-63. 2003
    Progesterone acts via two specific receptors to affect gene transcription in target tissues. Progesterone receptor (PR) B contains 933 amino acids while PR A is a truncated version lacking the initial 164 amino acids...
  77. ncbi A functional polymorphism in the progesterone receptor gene is associated with an increase in breast cancer risk
    Immaculata De Vivo
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer Res 63:5236-8. 2003
    ..Because the effects of progesterone require the progesterone receptor (PGR), which exists in two isoforms, PR-A and PR-B, we sought to determine whether the functional ..
  78. ncbi Association of progesterone receptor polymorphism with recurrent abortions
    Andreas Schweikert
    Division of Gynecological Endocrinology and Reproductive Medicine, Department of Obstetrics and Gynecology, University of Erlangen Nurnberg, Universitätsstrasse 21 23, 91054 Erlangen, Germany
    Eur J Obstet Gynecol Reprod Biol 113:67-72. 2004
    The current study sought for polymorphisms within the progesterone receptor (PR) gene. Allele and genotype frequencies of patients with repeated abortions were compared to a control group.
  79. ncbi Differential regulation of the human progesterone receptor gene through an estrogen response element half site and Sp1 sites
    Larry N Petz
    Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, 524 Burrill Hall, 407 South Goodwin Avenue, Urbana, IL 61801, USA
    J Steroid Biochem Mol Biol 88:113-22. 2004
    The progesterone receptor (PR) gene is regulated by estrogen in normal reproductive tissues and in MCF-7 human breast cancer cells...
  80. ncbi Breast cancer patients with progesterone receptor PR-A-rich tumors have poorer disease-free survival rates
    Torsten A Hopp
    Department of Medicine, and Breast Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Clin Cancer Res 10:2751-60. 2004
    No study has yet analyzed whether changes in relative expression levels of progesterone receptor (PR) isoforms A and B in human breast tumors have significance in predicting clinical outcome...
  81. pmc The progesterone receptor Val660-->Leu polymorphism and breast cancer risk
    Immaculata De Vivo
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Breast Cancer Res 6:R636-9. 2004
    ..its receptor; thus, genetic variations, which might cause alterations in the biological function in the progesterone receptor (PGR), can potentially contribute to an individual's susceptibility to breast cancer...
  82. ncbi Progesterone-independent effects of human progesterone receptors (PRs) in estrogen receptor-positive breast cancer: PR isoform-specific gene regulation and tumor biology
    Britta M Jacobsen
    Department of Medicine, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
    Mol Endocrinol 19:574-87. 2005
    ....
  83. ncbi A germline variation in the progesterone receptor gene increases transcriptional activity and may modify ovarian cancer risk
    Irina U Agoulnik
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Clin Endocrinol Metab 89:6340-7. 2004
    Recently, we and others have detected a haplotype of the human progesterone receptor gene (PR). This haplotype consists of a 320-bp insertion in intron G together with point mutations in exons 4 and 5 and was named PROGINS...
  84. ncbi Progesterone receptor promoter +331A polymorphism is associated with a reduced risk of endometrioid and clear cell ovarian cancers
    Andrew Berchuck
    Division of Gynecologic Oncology, Duke University Medical Center, Box 3079, Durham, NC 27710, USA
    Cancer Epidemiol Biomarkers Prev 13:2141-7. 2004
    ..A functional single nucleotide polymorphism in the promoter of the progesterone receptor (+331A) alters the relative abundance of the A and B isoforms and has been associated with an increased ..
  85. pmc Ligand-specific dynamics of the progesterone receptor in living cells and during chromatin remodeling in vitro
    Geetha V Rayasam
    Laboratory of Receptor Biology and Gene Expression, Building 41, B602, National Cancer Institute, National Institutes of Health, 41 Library Dr, Bethesda, MD 20892 5055, USA
    Mol Cell Biol 25:2406-18. 2005
    b>Progesterone receptor (PR), a member of the nuclear receptor superfamily, is a key regulator of several processes in reproductive function...
  86. pmc Human progesterone receptor displays cell cycle-dependent changes in transcriptional activity
    Ramesh Narayanan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Biol 25:2885-98. 2005
    The human progesterone receptor (PR) contains multiple Ser-Pro phosphorylation sites that are potential substrates for cyclin-dependent kinases, suggesting that PR activity might be regulated during the cell cycle...
  87. pmc The breast cancer susceptibility gene BRCA1 regulates progesterone receptor signaling in mammary epithelial cells
    Yongxian Ma
    Department of Oncology, Lombardi Cancer Center, Georgetown University, Washington, DC 20057 1469, USA
    Mol Endocrinol 20:14-34. 2006
    The progesterone receptor (PR) plays roles in normal mammary development and breast cancer formation, where it may exert both stimulatory and inhibitory actions...
  88. ncbi Variant progesterone receptor mRNAs are co-expressed with the wild-type progesterone receptor mRNA in human endometrium during all phases of the menstrual cycle
    P B Marshburn
    Division of Reproductive Endocrinology and Infertility, Carolinas Medical Center, Charlotte, NC 28232, USA
    Mol Hum Reprod 11:809-15. 2005
    b>Progesterone receptor (PR) variant mRNAs in human endometrium could encode proteins with the potential to alter progesterone action in states of normal and abnormal endometrial development...
  89. ncbi Dual roles for the phosphatase PPM1D in regulating progesterone receptor function
    David A Proia
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Biol Chem 281:7089-101. 2006
    ..We found that PPM1D stimulated the activity of several nuclear receptors including the progesterone receptor (PR) and estrogen receptor...
  90. ncbi Two functionally relevant polymorphisms in the human progesterone receptor gene (+331 G/A and progins) and the predisposition for breast and/or ovarian cancer
    Andrea Romano
    Department of Obstetrics and Gynaecology, University Hospital of Maastricht, The Netherlands
    Gynecol Oncol 101:287-95. 2006
    Two polymorphisms affecting either expression (+331 G/A) or transcriptional activity (progins) of the progesterone receptor have been described. No clear correlation between either polymorphism and breast or ovarian cancer has been shown...
  91. ncbi Progesterone signaling in human myometrium through two novel membrane G protein-coupled receptors: potential role in functional progesterone withdrawal at term
    Emmanouil Karteris
    Division of Clinical Science, University of Warwick, Coventry, UK
    Mol Endocrinol 20:1519-34. 2006
    ..Our data indicate the presence of a novel signaling pathway mediated by mPRs that may result in a functional progestin withdrawal, shifting the balance from a quiescent state to one of contraction...
  92. ncbi Association of the progesterone receptor gene with breast cancer risk: a single-nucleotide polymorphism tagging approach
    Karen A Pooley
    Department of Oncology, Cancer Research UK, University of Cambridge, Strangeways Research Laboratory
    Cancer Epidemiol Biomarkers Prev 15:675-82. 2006
    Association studies on susceptibility to breast cancer using single nucleotide polymorphisms (SNP) in the progesterone receptor (PGR) gene have been previously published, but the results have been inconclusive...
  93. ncbi Progesterone receptor plays a major antiinflammatory role in human myometrial cells by antagonism of nuclear factor-kappaB activation of cyclooxygenase 2 expression
    Daniel B Hardy
    Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9038, USA
    Mol Endocrinol 20:2724-33. 2006
    ..is likely mediated by a concerted series of biochemical events that negatively impact the ability of the progesterone receptor (PR) to regulate target genes that maintain myometrial quiescence...
  94. ncbi Progesterone receptor polymorphism +331G/A is associated with a decreased risk of deep infiltrating endometriosis
    K J A F van Kaam
    Research Institute GROW, University of Maastricht, The Netherlands
    Hum Reprod 22:129-35. 2007
    Alterations in the progesterone receptor (PR) are considered a risk factor for the development of endometriosis...
  95. ncbi Focal subnuclear distribution of progesterone receptor is ligand dependent and associated with transcriptional activity
    Rebecca L Arnett-Mansfield
    Westmead Institute for Cancer Research, Westmead Hospital, Westmead, New South Wales 2145, Australia
    Mol Endocrinol 21:14-29. 2007
    The progesterone receptor (PR) is a critical mediator of progesterone action in the female reproductive system...
  96. ncbi The progesterone receptor gene polymorphism, PROGINS, may be a factor related to the development of uterine fibroids
    Mariano Tamura Vieira Gomes
    Department of Gynecology, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    Fertil Steril 87:1116-21. 2007
    To assess the possible association between the polymorphic allele of the progesterone receptor gene, named PROGINS, and uterine leiomyomas.
  97. ncbi Genetic polymorphisms of cytochrome P450cl7alpha (CYP17) and progesterone receptor genes (PROGINS) in the assessment of endometriosis risk
    Cristina Valleta De Carvalho
    Molecular Gynecology Laboratory, Federal University of Sao Paulo, Sao Paulo, Brazil
    Gynecol Endocrinol 23:29-33. 2007
    ..evaluate the eventual role of polymorphisms in the genes encoding cytochrome P450c17alpha (CYP17) and the progesterone receptor (PROGINS) as risk factors for endometriosis development...
  98. ncbi Association of progesterone receptor gene polymorphism (PROGINS) with endometriosis, uterine fibroids and breast cancer
    S Govindan
    Department of Genetics, Vasavi Medical and Research Centre, Khairtabad, Hyderabad 500 004, Andhra Pradesh, India
    Cancer Biomark 3:73-8. 2007
    ..study has been carried out to identify the association of 306bp Alu insertion polymorphism in intron 7 of progesterone receptor gene (PROGINS)...
  99. pmc Association of progesterone receptor polymorphisms with recurrent implantation failure after in vitro fertilization and embryo transfer
    Carolyn B Coulam
    Pregnancy Success Center of Rinehart Center for Reproductive Medicine, Evanston, IL, USA
    J Assist Reprod Genet 25:119-22. 2008
    ..The actions of progesterone are mediated by the progesterone receptor. Polymorphic variants of human progesterone receptor genes have been implicated in implantation failure.
  100. pmc The androgen and progesterone receptors regulate distinct gene networks and cellular functions in decidualizing endometrium
    Brianna Cloke
    Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, London W12 0NN, United Kingdom
    Endocrinology 149:4462-74. 2008
    ..By combining small interfering RNA technology with genome-wide expression profiling, we found that AR and progesterone receptor (PR) regulate the expression of distinct decidual gene networks...
  101. pmc Polymorphisms in genes involved in sex hormone metabolism, estrogen plus progestin hormone therapy use, and risk of postmenopausal breast cancer
    Brenda Diergaarde
    Cancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center and Department of Epidemiology, University of Washington, Seattle, WA, USA
    Cancer Epidemiol Biomarkers Prev 17:1751-9. 2008
    ..Our results support the hypothesis that specific polymorphisms in genes involved in sex hormone metabolism may modify the effect of E+P use on breast cancer risk...

Research Grants62

  1. Michael J Soares; Fiscal Year: 2014
    ..estrogen receptor alpha (ESR1) and estrogen receptor beta (ESR2), while progesterone signals through the progesterone receptor (PGR)...
  2. Richard L Stouffer; Fiscal Year: 2015
    ..Recent evidence suggests that specific genomic progesterone receptor isoforms (PGR-A and -B) regulate different activities in target tissue;and the discovery of nongenomic PGR ..
  3. Ruth Lupu; Fiscal Year: 2014
    ..Receptor positive (ER+), HER2 3+ overexpressing (HER2+) and triple negative (TN) [which do not express ER, Progesterone Receptor (PgR), and HER2+)...
  4. ESTROGENIC REGULATION OF MAMMARY PROGESTERONE RECEPTORS
    G Shyamala; Fiscal Year: 1990
    ..the activation and/or interaction of mammary ER with DNA nd chromatin; (2) to characterize the mammary progesterone receptor (PgR) in detail with emphasis on receptor heterogeneity and subunit composition; (3) to examine whether ..
  5. Flaxseed vs. aromatase inhibitors: breast tumor characteristics and prognosis
    Susan McCann; Fiscal Year: 2009
    ....
  6. Dietary lignan effects on hormone, growth, and signaling factors in breast tumors
    Susan McCann; Fiscal Year: 2009
    ..The results of this study may provide us with important information that can be useful in understanding the effect of diet on development of different breast cancer sub-types. ..
  7. MECHANISM OF HORMONAL CONTROL OF MAMMARY CARCINOMA
    Suzanne Fuqua; Fiscal Year: 1993
    ....
  8. MECHANISM OF HORMONAL CONTROL OF MAMMARY CARCINOMA
    WILLIAM MC GUIRE; Fiscal Year: 1992
    ....
  9. Development and validation of predictors of endocrine treatment sensitivity
    Christos Hatzis; Fiscal Year: 2007
    ..for prediction of response to adjuvant tamoxifen therapy compared to standard markers such as ER and the progesterone receptor (PGR)...
  10. Estrogen and Progesterone-related Gene Variants and Colorectal Cancer Risk
    Shumin Zhang; Fiscal Year: 2009
    ....
  11. Breast cancer and HRT: genetic susceptibility within th*
    Kathleen Malone; Fiscal Year: 2006
    ..exogenous progesterone may influence carcinogenesis is through its proliferative effect on cells via the progesterone receptor B (PRB) and the differential metabolism of exogenous progesterone affecting the availability of ..
  12. Ethics and Safeguards in Psychiatric Research
    Laura W Roberts; Fiscal Year: 2010
    ..Our proposed endeavor will generate new knowledge for wide dissemination and publication that can inform future evidence-based PGR ethics guidelines and generate further empirical ethics research on PGR. ..
  13. GENERATION OF AN INDUCIBLE SYSTEM IN THE UTERINE STROMA FOR IMPLANTATION STUDIES
    Liang Ma; Fiscal Year: 2013
    ..This mouse strain should be a valuable tool for researchers studying implantation as well as embryonic or postnatal organogenesis and carcinogenesis. ..
  14. JERAMIAH JAMES SMITH; Fiscal Year: 2016
    ..These studies are expected to provide unique insight into vertebrate genome biology and yield information that might not be achievable outside of the context of PGR. ..
  15. Chris T Amemiya; Fiscal Year: 2014
    ..The inadequacy of the lamprey genome sequence, however, is highly problematic for researchers studying this organism. Development of an improved lamprey genome sequence is thus imperative for the community. ..
  16. LIGHT DURING DARKNESS AND BREAST CANCER PROGRESSION
    David Blask; Fiscal Year: 2004
    ..dose-response effects of exposure of nude female rats, bearing tissue-isolated estrogen receptor (ER)+ and progesterone receptor (PgR)+ MCF-7 human breast cancer xenografts, to different intensities of white light during darkness, on ..
  17. RECEPTOR MEDIATED RADIATION ONCOLOGY
    WILLIAM BLOOMER; Fiscal Year: 1991
    ....
  18. Immunotoxicity of indirubin, a plant-based AhR ligand
    Charles Rice; Fiscal Year: 2005
    ..The following proposal tests the hypothesis that indirubin is a potent immunotoxic compound. ..
  19. FLUORESCENT STEROID BINDING IN ENDOMETRICAL CARCINOMA
    DONALD TOURVILLE; Fiscal Year: 1992
    ..Conventional biochemical estrogen (ER) and progesterone receptor (PgR) assays are difficult to perform and interpret in this malignancy since specimens often contain ..
  20. FLUORESCENT STEROID CONJUGATES FOR ER AND PR STUDIES
    Gary Chamness; Fiscal Year: 1990
    ....
  21. MOLECULAR MODULATION OF HSV VECTOR CNS INTERACTIONS
    John Olschowka; Fiscal Year: 2003
    ..The effectiveness of each manipulation will be assayed with the same methods used in Specific Aim 1. ..
  22. ENZYMES IN EICOSANOID METABOLISM
    Hsin Hsiung Tai; Fiscal Year: 2004
    ..Furthermore, the program should uncover novel properties of 5-HEDH and shed some light on the role of this enzyme in the inflammatory and allergic reactions. ..
  23. Molecular Diagnostics for Breast Cancer
    Philip Bernard; Fiscal Year: 2004
    ..Multivariate analyses will be used to show statistical significance of molecular classifications. This study should provide a framework for molecular diagnostic testing of solid tumors in the clinical laboratory. ..
  24. QUANTITATION AND ARCHIVING OF GENE EXPRESSION
    John Gerdes; Fiscal Year: 2000
    ..An improved and more precise method of detecting gene expression levels that have been shown to be of prognostic and therapeutic importance has great commercialization potential. ..
  25. Gene Interactions, Estrogen, and Risk of Breast Cancer
    Kathleen Egan; Fiscal Year: 2006
    ..abstract_text> ..
  26. OVINE INTERFERON-TAU REGULATES UTERINE HORMONE RECEPTOR
    Fuller Bazer; Fiscal Year: 2005
    ....
  27. Bridges to the Doctorate in Reproductive Biology
    Fuller Bazer; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  28. Whole genome amplification and DNA pooling strategies
    Immaculata DeVivo; Fiscal Year: 2004
    ..Results from the pooling experiments will determine whether this method may be sensitive enough for use in nested case-control studies where a small difference in allele frequency is expected. ..
  29. Pharmacogenetic Epidemiology of Birth Defects and Cancer
    Timothy Rebbeck; Fiscal Year: 2004
    ....
  30. Progesterone regulation of human luteal cell viability
    John Peluso; Fiscal Year: 2006
    ..Such selective manipulation of the P4's actions could have far reaching effects on the treatment for infertility, contraception and certain types of cancers. [unreadable] [unreadable]..
  31. Protein Kinase G Regulation of Granulosa Cell Viability
    John Peluso; Fiscal Year: 2006
    ..We now propose to test this hypothesis using biochemical, genetic, imaging and cell biological techniques. [unreadable] [unreadable]..
  32. The Progesterone Receptor Gene and Ovarian Cancer Risk
    CELESTE PEARCE; Fiscal Year: 2005
    The progesterone receptor gene (PGR) is a strong candidate gene for invasive epithelial ovarian cancer (ovarian cancer) susceptibility based on both experimental and epidemiologic observations...
  33. Regulation of Oocyte Viability by Granulosa Cell Contact
    John Peluso; Fiscal Year: 2004
    ..abstract_text> ..
  34. Ovarian Cancer and Gonadotropin Signaling
    CELESTE PEARCE; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  35. A Pooled Analysis to Identify New Ovarian Cancer Risk Factors
    Celeste Leigh Pearce; Fiscal Year: 2010
    ..Gaining a better understanding of ovarian cancer, which this project will provide, is critical to identifying women at risk and for improving the outcome for women who are diagnosed with this disease. ..
  36. ANTIOXIDANTS AND FEMALE HORMONES IN THE ETIOLOGY OF RA
    Elizabeth Karlson; Fiscal Year: 2002
    ..RA will be confirmed by a screening questionnaire regarding rheumatic symptoms and review of medical records. The study will identify potentially modifiable risk factors for primary prevention of RA. ..
  37. FSHD Syndrome: DNA Repeats, Methylation, & Chromatin
    Melanie Ehrlich; Fiscal Year: 2003
    ..The proposed research should help elucidate the molecular etiology of the enigmatic FSHD syndrome. ..
  38. Fox Chase Cancer Center Breast Cancer Tissue Resources
    Jose Russo; Fiscal Year: 2008
    ..abstract_text> ..
  39. Regulation of Pregnancy-Dependent Adaptations
    Michael Soares; Fiscal Year: 2009
    ..Novel ideas and a novel research approach have been presented to elucidate regulatory mechanisms controlling fundamental processes essential for the establishment and maintenance of pregnancy. ..
  40. MOUSE CANCER MODELS BY REGULATED INACTIVATION OF TUMOR S
    Eva Lee; Fiscal Year: 2003
    ..These valuable mouse models will be extremely useful for the general community of cancer researchers. ..
  41. Dendritic Processing in the Olfactory Bulb
    Jason Christie; Fiscal Year: 2003
    ..The specific aims are: (1) to determine the function of autoexcitation in mitral cell processing and (2) to determine how dendritic compartmentalization effects mitral cell processing. ..
  42. Nutrition, Fetal Growth, and Placental Angiogenesis
    Lawrence P Reynolds; Fiscal Year: 2010
    ..abstract_text> ..
  43. Epigenetic Changes Induced by Estrogens and Xenoestrogens in Breast Cancer
    Jose Russo; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  44. CASE CONTROL STUDY OF OVARIAN CANCER HORMONAL ETIOLOGY
    Harvey Risch; Fiscal Year: 2002
    ....
  45. DNA POLYMORPHISMS IN OVARIAN CANCER--CASE CONTROL STUDY
    Harvey Risch; Fiscal Year: 2002
    ..abstract_text> ..
  46. GENE EXPRESSION BASED CLASSIFICATION OF GLIAL TUMORS
    Stanley Nelson; Fiscal Year: 2004
    ..3)To develop a set of genes with prognostic importance in low grade astrocytomas. 4)To validate the importance of the genes from specific aims 2 and 3 in the prognosis of low grade astrocytomas. ..
  47. MECHANISMS REGULATING UTERINE MORPHOGENESIS
    Thomas Spencer; Fiscal Year: 2004
    ....
  48. DETERMINANTS OF TISSUE ESTRADIOL SENSITIVITY
    Richard Santen; Fiscal Year: 2009
    ..FTS, a novel mTOR inhibitor will be used in vitro to activate the stress kinase pathway and apoptosis. In vivo, FTS will be used to enhance estradiol induced apoptosis in nude mice. ..
  49. Biology at the Maternal-Fetal Interface
    Michael Soares; Fiscal Year: 2006
    ..The overall goal of the program project is to understand regulatory processes that will lead to the development of therapeutic strategies for the purpose of improving the quality and success of pregnancy. ..
  50. 4-Hydroxyestradiol Receptor in Breast Cancer
    Jose Russo; Fiscal Year: 2005
    ..This plan is in line with goals 1 and 3 of the Breast Cancer Progress Review Group to better understand the biology of the normal mammary gland and of precancerous lesions. ..
  51. Case-Control Study of Pancreas Cancer Etiologic Factors
    Harvey Risch; Fiscal Year: 2008
    ..The factors to be examined here have received little attention with respect to pancreas cancer, and the proposed study will evaluate them systematically in a vigorous, large-scale and integrated project. [unreadable] [unreadable]..
  52. Genetic Regulation of Postnatal Uterine Morphogenesis and Function
    Thomas Spencer; Fiscal Year: 2008
    ..ablate Wnt7a in the epithelium of the uterus after birth using the Cre/LoxP system and the innovative progesterone receptor-Cre knockin mouse model...
  53. Hormones, hormone-related genes, and colorectal cancer
    Jennifer Lin; Fiscal Year: 2008
    ..aromatase cytochrome P450 gene (CYP19A1), estrogen receptor alpha (ESR1), estrogen receptor beta (ESR2), progesterone receptor (PGR) and CRC risk...
  54. Society of Gynecologic Investigation Annual Meeting
    Andrew Berchuck; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  55. UCLA NHLBI Shared Microarray Facilities
    Stanley Nelson; Fiscal Year: 2005
    ..As large scale data handling and processing can be a daunting task for biologists, we propose to provide dedicated expert data managing and statistical assistance. ..
  56. PROGESTERONE RECEPTOR A AND B PROTEINS IN REPRODUCTION
    ORLA CONNEELY; Fiscal Year: 2008
    ..abstract_text> ..
  57. P13K/AKT crosstalk with ER-signaling and cell survival
    Matthew Burow; Fiscal Year: 2008
    ..This cross-talk and the mechanisms identified will be used to establish the biological relevancy of the pathway in terms of cell survival and altered SERM activity. ..
  58. THE MAJOR ANGIOGENIC FACTORS IN PLACENTAL ANGIOGENESIS
    Lawrence Reynolds; Fiscal Year: 2004
    ..abstract_text> ..
  59. Physiological Genomics of Pregnancy
    Michael Soares; Fiscal Year: 2007
    ..The proposed analysis should lead to effective strategies for identifying genes implicated in diseases leading to pregnancy failure. [unreadable] [unreadable] [unreadable]..
  60. Genomic Basis of Reproductive History on Breast Cancer
    Jose Russo; Fiscal Year: 2006
    ..abstract_text> ..
  61. Oncogenes and loss of ER in a new p53 breast tumor model
    Eva Lee; Fiscal Year: 2006
    ..These proposed studies should provide significant insights into molecular events involved in breast cancer progression and critical information for anti-estrogen based breast cancer prevention and intervention. ..