PRODH

Summary

Gene Symbol: PRODH
Description: proline dehydrogenase 1
Alias: HSPOX2, PIG6, POX, PRODH1, PRODH2, TP53I6, proline dehydrogenase 1, mitochondrial, p53-induced gene 6 protein, proline dehydrogenase (oxidase) 1, proline oxidase 2, proline oxidase, mitochondrial, tumor protein p53 inducible protein 6
Species: human

Top Publications

  1. ncbi [Serologic studies of domestic cats for potential human pathogenic virus infections from wild rodents]
    N Nowotny
    Institut fur Virologie, Veterinärmedizinischen Universität Wien
    Zentralbl Hyg Umweltmed 198:452-61. 1996
  2. ncbi Genetic and temporal determinants of pesticide sensitivity: role of paraoxonase (PON1)
    C E Furlong
    Department of Genetics, University of Washington, Seattle 98195 7360, USA
    Neurotoxicology 21:91-100. 2000
  3. ncbi Characterization of poxviruses from forest birds in Hawaii
    D N Tripathy
    Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana 61801, USA
    J Wildl Dis 36:225-30. 2000
  4. doi Oxidative stress induction by Prunus necrotic ringspot virus infection in apricot seeds
    Khalid Amari
    Department of Stress Biology and Plant Pathology, CEBAS CSIC, PO Box 164, 30100 Espinardo, Murcia, Spain
    Physiol Plant 131:302-10. 2007
  5. pmc Schizophrenia susceptibility associated with interstitial deletions of chromosome 22q11
    M Karayiorgou
    Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA
    Proc Natl Acad Sci U S A 92:7612-6. 1995
  6. ncbi A model for p53-induced apoptosis
    K Polyak
    The Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 389:300-5. 1997
  7. ncbi The gene encoding proline dehydrogenase modulates sensorimotor gating in mice
    J A Gogos
    The Rockefeller University, New York, New York 10021, USA
    Nat Genet 21:434-9. 1999
  8. ncbi Proline oxidase, encoded by p53-induced gene-6, catalyzes the generation of proline-dependent reactive oxygen species
    S P Donald
    Division of Basic Science, National Cancer Institute, Frederick, Maryland 21702, USA
    Cancer Res 61:1810-5. 2001
  9. pmc Genetic variation at the 22q11 PRODH2/DGCR6 locus presents an unusual pattern and increases susceptibility to schizophrenia
    Hui Liu
    Human Neurogenetics Laboratory, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 99:3717-22. 2002
  10. ncbi PRODH mutations and hyperprolinemia in a subset of schizophrenic patients
    Hélène Jacquet
    INSERM EMI 9906, IRFMP, Faculty of Medicine, 76183 Rouen, France
    Hum Mol Genet 11:2243-9. 2002

Detail Information

Publications204 found, 100 shown here

  1. ncbi [Serologic studies of domestic cats for potential human pathogenic virus infections from wild rodents]
    N Nowotny
    Institut fur Virologie, Veterinärmedizinischen Universität Wien
    Zentralbl Hyg Umweltmed 198:452-61. 1996
    ..in different ways, may lead to serious human illness: Ortho- and parapoxvirus infections may cause localized pox lesions following direct skin contact...
  2. ncbi Genetic and temporal determinants of pesticide sensitivity: role of paraoxonase (PON1)
    C E Furlong
    Department of Genetics, University of Washington, Seattle 98195 7360, USA
    Neurotoxicology 21:91-100. 2000
    ..The Arg192 isoform (PON1R192) of this HDL-associated protein hydrolyzes paraoxon (POX) at a high rate, while the Gln192 isoform (PON1Q192) hydrolyzes paraoxon at a low rate...
  3. ncbi Characterization of poxviruses from forest birds in Hawaii
    D N Tripathy
    Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana 61801, USA
    J Wildl Dis 36:225-30. 2000
    Two strains of avian pox viruses were isolated from cutaneous lesions in Hawaiian crows (Corvus hawaiiensis) examined in 1994 and a third from a biopsy obtained in 1992 from an infected bird of the Apapane species (Himatione sanguinea) ..
  4. doi Oxidative stress induction by Prunus necrotic ringspot virus infection in apricot seeds
    Khalid Amari
    Department of Stress Biology and Plant Pathology, CEBAS CSIC, PO Box 164, 30100 Espinardo, Murcia, Spain
    Physiol Plant 131:302-10. 2007
    ..A significant decrease in the ascorbate-GSH cycle enzymes as well as in peroxidase (POX) activity took place in infected seeds, suggesting a low capability to eliminate H2O2...
  5. pmc Schizophrenia susceptibility associated with interstitial deletions of chromosome 22q11
    M Karayiorgou
    Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA
    Proc Natl Acad Sci U S A 92:7612-6. 1995
    ..Our findings should facilitate identification and cloning of the schizophrenia susceptibility gene(s) in this region and identification of more homogeneous subgroups of patients...
  6. ncbi A model for p53-induced apoptosis
    K Polyak
    The Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 389:300-5. 1997
    ....
  7. ncbi The gene encoding proline dehydrogenase modulates sensorimotor gating in mice
    J A Gogos
    The Rockefeller University, New York, New York 10021, USA
    Nat Genet 21:434-9. 1999
    ..Here we report the isolation and characterization of PRODH, a human homologue of Drosophila melanogaster sluggish-A (slgA), which encodes proline dehydrogenase responsible ..
  8. ncbi Proline oxidase, encoded by p53-induced gene-6, catalyzes the generation of proline-dependent reactive oxygen species
    S P Donald
    Division of Basic Science, National Cancer Institute, Frederick, Maryland 21702, USA
    Cancer Res 61:1810-5. 2001
    The p53-dependent initiation of apoptosis is accompanied by the induction of proline oxidase (POX), a mitochondrial enzyme catalyzing the conversion of proline to pyrroline-5-carboxylate with the concomitant transfer of electrons to ..
  9. pmc Genetic variation at the 22q11 PRODH2/DGCR6 locus presents an unusual pattern and increases susceptibility to schizophrenia
    Hui Liu
    Human Neurogenetics Laboratory, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 99:3717-22. 2002
    ..In three independent samples, we provide evidence for a contribution of the PRODH2/DGCR6 locus in 22q11-associated schizophrenia...
  10. ncbi PRODH mutations and hyperprolinemia in a subset of schizophrenic patients
    Hélène Jacquet
    INSERM EMI 9906, IRFMP, Faculty of Medicine, 76183 Rouen, France
    Hum Mol Genet 11:2243-9. 2002
    ..led us to identify, in a family including two schizophrenic subjects, a heterozygous deletion of the entire PRODH gene encoding proline dehydrogenase...
  11. ncbi Proline oxidase induces apoptosis in tumor cells, and its expression is frequently absent or reduced in renal carcinomas
    Steve A Maxwell
    Texas A and M University System Health Science Center, Department of Pathology and Laboratory Medicine, College Station, Texas 77843 1114, USA
    J Biol Chem 278:9784-9. 2003
    ..The presence of proline oxidase in mitochondria, a primary organelle that regulates apoptosis, places this molecule in a subcellular localization that can directly influence the apoptotic pathway and thus tumorigenesis...
  12. pmc The severe form of type I hyperprolinaemia results from homozygous inactivation of the PRODH gene
    H Jacquet
    INSERM EMI 9906 IFRMP, Faculty of Medicine, Rouen, France
    J Med Genet 40:e7. 2003
  13. ncbi Detailed analysis of PRODH and PsPRODH reveals no association with schizophrenia
    H J Williams
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 120:42-6. 2003
    ..Recently, the gene proline dehydrogenase (PRODH) which maps to 22q11 and is also an excellent functional candidate gene for psychosis, has been reported to show ..
  14. ncbi Evidence for association between novel polymorphisms in the PRODH gene and schizophrenia in a Chinese population
    Tao Li
    Division of Psychological Medicine, Institute of Psychiatry, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 129:13-5. 2004
    ..disequilibrium mapping of the region in patients identified a segment containing two genes, proline dehydrogenase (PRODH) and DGCR6, as candidates [Liu et al...
  15. ncbi Hyperprolinemia is a risk factor for schizoaffective disorder
    H Jacquet
    INSERM U614, IFRMP, Faculte de Medecine, Rouen 76183, France
    Mol Psychiatry 10:479-85. 2005
    ..we identified several heterozygous alterations, including a complete deletion, of the proline dehydrogenase (PRODH) gene, which were associated with moderate hyperprolinemia in a subset of DSM III schizophrenic patients...
  16. pmc Functional consequences of PRODH missense mutations
    Hans Ulrich Bender
    Howard Hughes Medical Institute, and Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Am J Hum Genet 76:409-20. 2005
    b>PRODH maps to 22q11 in the region deleted in the velocardiofacial syndrome/DiGeorge syndrome (VCFS/DGS) and encodes proline oxidase (POX), a mitochondrial inner-membrane enzyme that catalyzes the first step in the proline degradation ..
  17. ncbi No evidence for an association between variants at the proline dehydrogenase locus and schizophrenia or bipolar affective disorder
    Rami Abou Jamra
    Institute of Human Genetics, University of Bonn, D 53111 Bonn, Germany
    Psychiatr Genet 15:195-8. 2005
    ..Neither single marker nor haplotype analysis revealed an association between variants at the proline dehydrogenase locus and schizophrenia or bipolar affective disorder...
  18. ncbi Proline oxidase, a proapoptotic gene, is induced by troglitazone: evidence for both peroxisome proliferator-activated receptor gamma-dependent and -independent mechanisms
    Jui Pandhare
    Metabolism and Cancer Susceptibility Section, Laboratory of Comparative Carcinogenesis, Center for Cancer Research, NCI Frederick, National Institutes of Health, Frederick, MD 21702, USA
    J Biol Chem 281:2044-52. 2006
    Proline oxidase (POX) is a redox enzyme localized in the mitochondrial inner membrane. We and others have shown that POX is a p53-induced gene that can mediate apoptosis through generation of reactive oxygen species (ROS)...
  19. ncbi Proline oxidase activates both intrinsic and extrinsic pathways for apoptosis: the role of ROS/superoxides, NFAT and MEK/ERK signaling
    Y Liu
    Metabolism and Cancer Susceptibility Section, Laboratory of Comparative Carcinogenesis, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
    Oncogene 25:5640-7. 2006
    Proline oxidase (POX), often considered a 'housekeeping enzyme' might play an important role in apoptosis...
  20. ncbi Association study of the G-protein signaling 4 (RGS4) and proline dehydrogenase (PRODH) genes with schizophrenia: a meta-analysis
    Dawei Li
    Bio X Life Science Research Center, Shanghai Jiao Tong University, Shanghai, China
    Eur J Hum Genet 14:1130-5. 2006
    ..and functional studies have implicated the regulator of G-protein signaling 4 (RGS4) and proline dehydrogenase (PRODH) genes as promising and novel candidates for explaining schizophrenia...
  21. ncbi Analysis of ProDH, COMT and ZDHHC8 risk variants does not support individual or interactive effects on schizophrenia susceptibility
    Beate Glaser
    Department of Psychological Medicine, Cardiff University, Heath Park, Cardiff, UK, and Department of Psychiatry, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland
    Schizophr Res 87:21-7. 2006
    ..hypothesis, our study aimed to explore main, cis- and trans-interacting effects of three candidate genes on 22q11, ProDH, COMT and ZDHHC8...
  22. ncbi Overexpression of proline oxidase induces proline-dependent and mitochondria-mediated apoptosis
    Chien an A Hu
    Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, Albuquerque, NM, USA
    Mol Cell Biochem 295:85-92. 2007
    Proline oxidase (POX), a mitochondrial inner-membrane protein, catalyzes the rate-limiting oxidation of proline to pyrroline- 5-carboxylate (P5C)...
  23. ncbi Involvement of hyperprolinemia in cognitive and psychiatric features of the 22q11 deletion syndrome
    Gregory Raux
    Department of Genetics and Inserm U614, IFRMP, Faculty of Medicine, Rouen, France
    Hum Mol Genet 16:83-91. 2007
    ..mouse model that an interaction between two genes localized in the hemideleted region, proline dehydrogenase (PRODH) and catechol-o-methyl-transferase (COMT), could be involved in this phenotype...
  24. ncbi Early neurological phenotype in 4 children with biallelic PRODH mutations
    Alexandra Afenjar
    AP HP, Service de Neuropediatrie, Hopital Armand Trousseau, Paris, France
    Brain Dev 29:547-52. 2007
    ..Diverse phenotypes were described in patients with HPI, prior to the identification of the POX gene (PRODH): whereas various patients were asymptomatic, others had neurological and extraneurological defects...
  25. ncbi Genetic variation in COMT and PRODH is associated with brain anatomy in patients with schizophrenia
    J Zinkstok
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, The Netherlands
    Genes Brain Behav 7:61-9. 2008
    Haploinsufficiency of 22q11 genes including catechol-O-methyltransferase (COMT) and proline dehydrogenase (PRODH) may result in structural and functional brain abnormalities and increased vulnerability to schizophrenia as observed in ..
  26. pmc Functional polymorphisms in PRODH are associated with risk and protection for schizophrenia and fronto-striatal structure and function
    Lucas Kempf
    Department of Health and Human Services, Unit of Systems Neuroscience in Psychiatry, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Genet 4:e1000252. 2008
    b>PRODH, encoding proline oxidase (POX), has been associated with schizophrenia through linkage, association, and the 22q11 deletion syndrome (Velo-Cardio-Facial syndrome)...
  27. pmc Regulation and function of proline oxidase under nutrient stress
    Jui Pandhare
    Metabolism and Cancer Susceptibility Section, Laboratory of Comparative, Carcinogenesis, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, USA
    J Cell Biochem 107:759-68. 2009
    ..extracellular matrix (ECM), and the degradation of proline through the proline cycle initiated by proline oxidase (POX), a mitochondrial inner membrane enzyme, can generate ATP...
  28. pmc Proline oxidase functions as a mitochondrial tumor suppressor in human cancers
    Yongmin Liu
    Basic Science Program and Pathology Histotechnology Laboratory, Science Applications International Corporation Frederick, Inc, and Laboratory of Comparative Carcinogenesis, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, USA
    Cancer Res 69:6414-22. 2009
    ..Proline oxidase (POX), catalyzing the first step in proline catabolism, is induced by p53 and can regulate cell survival as well as ..
  29. pmc Oxidized low-density lipoproteins upregulate proline oxidase to initiate ROS-dependent autophagy
    Olga Zabirnyk
    Metabolism and Cancer Susceptibility Section, Laboratory of Comparative Carcinogenesis, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702 1201, USA
    Carcinogenesis 31:446-54. 2010
    ..OxLDLs have ligands for peroxisome proliferator-activated receptor gamma and upregulated proline oxidase (POX) through this nuclear receptor...
  30. ncbi [Biohazard in clinical laboratories in Japan]
    T Masuda
    Department of Internal Medicine, Nagoya National Hospital
    Kansenshogaku Zasshi 65:209-15. 1991
    ..one case of campylobacter enteritis, one case of paratyphus, one case of salmonellosis and one case of chicken pox. There were no fatal cases...
  31. ncbi Inborn errors of proline metabolism
    Hiroshi Mitsubuchi
    Department of Pediatrics, Kumamoto University Graduate School of Medical Science, Kumamoto University, Kumamoto 860 8556, Japan
    J Nutr 138:2016S-2020S. 2008
    ..Hyperprolinemia type I (HPI) is a result of a deficiency in POX. The POX gene (PRODH) is located on chromosome 22 (22q11...
  32. pmc The metabolism of proline as microenvironmental stress substrate
    James M Phang
    Laboratory of Comparative Carcinogenesis, Center for Cancer Research, National Cancer Institute Frederick, Frederick, MD 21702, USA
    J Nutr 138:2008S-2015S. 2008
    ..Studies show that the proline-utilizing enzyme, proline oxidase (POX)/proline dehydrogenase (PRODH), responds to genotoxic, inflammatory, and nutrient stress...
  33. pmc A novel function for hydroxyproline oxidase in apoptosis through generation of reactive oxygen species
    Sandra K Cooper
    Basic Research Program, SAIC Frederick, Inc, NCI Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 283:10485-92. 2008
    ..The first steps in the degradation of proline and hydroxyproline are catalyzed by proline oxidase (POX) and hydroxyproline oxidase (OH-POX), respectively...
  34. ncbi Standard guidelines of care: CO2 laser for removal of benign skin lesions and resurfacing
    D S Krupashankar
    Department of Dermatology, Manipal Hospital, Bangalore, India
    Indian J Dermatol Venereol Leprol 74:S61-7. 2008
    Resurfacing is a treatment to remove acne and chicken pox scars, and changes in the skin due to ageing. MACHINES: Both ablative and nonablative lasers are available for use. CO 2 laser is the gold standard in ablative lasers...
  35. pmc miR-23b targets proline oxidase, a novel tumor suppressor protein in renal cancer
    W Liu
    Laboratory of Comparative Carcinogenesis, Center for Cancer Research, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD 21702, USA
    Oncogene 29:4914-24. 2010
    Proline oxidase (POX) is a novel mitochondrial tumor suppressor that can suppress proliferation and induce apoptosis through the generation of reactive oxygen species (ROS) and decreasing hypoxia-inducible factor (HIF) signaling...
  36. doi Type I hyperprolinemia: genotype/phenotype correlations
    Audrey Guilmatre
    INSERM U614, IHU, 76000 Rouen, France
    Hum Mutat 31:961-5. 2010
    ..associated with cognitive and psychiatric troubles, caused by alterations of the Proline Dehydrogenase gene (PRODH) at 22q11. HPI results from PRODH deletion and/or missense mutations reducing proline oxidase (POX) activity...
  37. doi Identification of a p53-response element in the promoter of the proline oxidase gene
    Steve A Maxwell
    Department of Molecular and Cellular Medicine, Room 252, College of Medicine, Texas A and M Health Science Center, College Station, TX 77843 1114, USA
    Biochem Biophys Res Commun 369:308-13. 2008
    Proline oxidase (POX) is a p53-induced proapoptotic gene. We investigated whether p53 could bind directly to the POX gene promoter. Chromatin immunoprecipitation (ChIP) assays detected p53 bound to POX upstream gene sequences...
  38. ncbi Apoptotic action of peroxisome proliferator-activated receptor-gamma activation in human non small-cell lung cancer is mediated via proline oxidase-induced reactive oxygen species formation
    Ki Young Kim
    Center for Metabolic Syndrome Therapeutics, Drug Discovery Division, Korea Research Institute of Chemical Technology, Daejeon, Korea
    Mol Pharmacol 72:674-85. 2007
    ..Reactive oxygen species (ROS) production was accompanied by increased expression of proline oxidase (POX), a redox enzyme expressed in mitochondria, upon incubation with the agonists...
  39. doi The metabolism of proline, a stress substrate, modulates carcinogenic pathways
    James M Phang
    Laboratory of Comparative Carcinogenesis, Center for Cancer Research, Building 538, Room 115, NCI Frederick, Frederick, MD 21702, USA
    Amino Acids 35:681-90. 2008
    ..Proline oxidase, a.k.a. proline dehydrogenase (POX/PRODH), catalyzes the first step in proline degradation and uses proline to generate ATP for survival or reactive oxygen ..
  40. ncbi Tiapride pre-treatment in acute exposure to paraoxon: comparison of effects of administration at different points-in-time in rats
    G A Petroianu
    Department of Pharmacology, FMHS UAE University, Al Ain, UAE
    Mol Cell Biochem 285:79-86. 2006
    ..We also have shown recently that in rats coadministration of TIA with the organophosphate paraoxon significantly decreases mortality without having an impact on red blood cell cholinesterase (RBC-AChE) activity...
  41. ncbi [Clinico-pathological aspect of HIV-sero positive inpatients]
    H Fujita
    First Department of Internal Medicine, Yokohama City University School of Medicine
    Kansenshogaku Zasshi 69:398-403. 1995
    ..encephalopathy and systemic various infection, including Pneumocystis carinii, cytomegalovirus, papilloma virus and pox virus...
  42. ncbi Peculiarities of dermatomyositis (DM) in early age
    T V Ryabova
    First Moscow Medical Institute, USSR
    Acta Univ Carol Med (Praha) 37:3-5. 1991
    ..The most frequent intercurrent diseases were respiratory infections, angina; the chicken-pox was frequent too. 12 children had food allergy and 20 children-drug allergy...
  43. ncbi Differential detection of turkey coronavirus, infectious bronchitis virus, and bovine coronavirus by a multiplex polymerase chain reaction
    C C Loa
    Department of Veterinary Pathobiology and Animal Disease Diagnostic Laboratory, Purdue University, West Lafayette, IN 47907 2065, USA
    J Virol Methods 131:86-91. 2006
    ..There were no PCR products with the same primers for Newcastle disease virus, Marek's disease virus, turkey pox virus, pigeon pox virus, fowl pox virus, reovirus, infectious bursal disease virus, enterovirus, astrovirus, ..
  44. ncbi Protective vaccination of ferrets against canine distemper with recombinant pox virus vaccines expressing the H or F genes of rinderpest virus
    L Jones
    Department of Veterinary Pathology, University of California, Davis 95616, USA
    Am J Vet Res 58:590-3. 1997
    To investigate the ability of rinderpest virus (RPV) antigens, expressed in pox virus vectors, to protect against canine distemper virus (CDV) infection in ferrets.
  45. ncbi Field trial in commercial broilers with a multivalent in ovo vaccine comprising a mixture of live viral vaccines against Marek's disease, infectious bursal disease, Newcastle disease, and fowl pox
    J M Sharma
    Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, St Paul 55108, USA
    Avian Dis 46:613-22. 2002
    ..19%; FPV, 86% vs. 0%. The successful use of MIV under field conditions expands the usefulness of the in ovo technology for poultry...
  46. ncbi In vitro oxime reactivation of red blood cell acetylcholinesterase inhibited by methyl-paraoxon
    G A Petroianu
    UAE University, Al Ain UAE
    J Appl Toxicol 27:168-75. 2007
    ..available (pralidoxime and methoxime) and experimental (K-27, K-33 and K-48) oximes, using methyl-paraoxon (methyl-POX) as an esterase inhibitor and to compare the results with those previously obtained using paraoxon (POX) as an ..
  47. ncbi Immunization, abrasion, and sunburn as localizing factors in chicken pox
    W B Shelley
    Department of Medicine, Medical College of Ohio, Toledo 43699
    Pediatr Dermatol 4:102-4. 1987
    ..This suggests that an injection given during an occult viremia could trigger an unexpected reaction at the site...
  48. ncbi Smallpox vaccination and bioterrorism with pox viruses
    Anton Mayr
    Institute of Microbiology, Infectious and Epidemic Diseases of the Veterinary, Faculty of the Ludwig Maximilian, University of Munich, Weiheimer Strasse 1, 823 19, Starnberg, Germany
    Comp Immunol Microbiol Infect Dis 26:423-30. 2003
    ..occupy a special place amongst the innumerable potential types of terrorist attack, with the intentional release of pox viruses being especially feared in this connection...
  49. ncbi Five oximes (K-27, K-33, K-48, BI-6 and methoxime) in comparison with pralidoxime: in vitro reactivation of red blood cell acetylcholinesterase inhibited by paraoxon
    G A Petroianu
    UAE University, Al Ain UAE
    J Appl Toxicol 26:64-71. 2006
    ..Paraoxon (POX), the active metabolite of parathion (O,O-diethyl-O-p-nitro-phenyl phosphorothioate) is a non-neuropathic ..
  50. ncbi Effect of pyridostigmine, pralidoxime and their combination on survival and cholinesterase activity in rats exposed to the organophosphate paraoxon
    Georg A Petroianu
    Faculty of Medicine and Health Sciences, Department of Pharmacology and Therapeutics, United Arab Emirates University, P O Box 17 666, Al Ain, United Arab Emirates
    Arch Toxicol 80:777-84. 2006
    ..to quantify in vivo the effect of PSTG pre-treatment on survival in rats exposed to the organophosphate paraoxon (POX) with and without subsequent reactivator (pralidoxime) treatment...
  51. pmc Expression of self-complementary hairpin RNA under the control of the rolC promoter confers systemic disease resistance to plum pox virus without preventing local infection
    Tiziana Pandolfini
    Dipartimento Scientifico Tecnologico, University of Verona, Strada Le Grazie 15, 37134 Verona, Italy
    BMC Biotechnol 3:7. 2003
    ..Plum pox virus (PPV) is the etiological agent of sharka disease in Drupaceae, although it can also be transmitted to ..
  52. ncbi Dispersal of Culex quinquefasciatus (Diptera: Culicidae) in a Hawaiian rain forest
    D A LaPointe
    U S Geological Survey, Pacific Island Ecosystems Research Center, P O Box 44, Hawaii National Park, HI 96718, USA
    J Med Entomol 45:600-9. 2008
    Introduced mosquito-borne pathogens avian malaria (Plasmodium relictum Grassi and Feletti) and avian pox virus (Avipoxvirus) have been implicated in the past extinctions and declines of Hawaiian avifauna and remain significant obstacles ..
  53. ncbi Protective agents in acute high-dose organophosphate exposure: comparison of ranitidine with pralidoxime in rats
    G A Petroianu
    Department of Pharmacology, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
    J Appl Toxicol 25:68-73. 2005
    ..This study evaluates RAN-conferred protection in acute high-dose organophosphate (paraoxon, POX) exposure in rats in direct comparison with the therapeutic gold-standard pralidoxime (PRX)...
  54. ncbi Analysis of the complete genome of peach chlorotic mottle virus: identification of non-AUG start codons, in vitro coat protein expression, and elucidation of serological cross-reactions
    D James
    Centre for Plant Health, Research Section, Sidney Laboratory, Canadian Food Inspection Agency, Sidney, British Columbia, Canada
    Arch Virol 152:2207-15. 2007
    ..Agua virus (4N6), was sequenced and analysed. PCMV cross-reacts with antisera to diverse viruses, such as plum pox virus (PPV), genus Potyvirus, family Potyviridae; and apple stem pitting virus (ASPV), genus Foveavirus, family ..
  55. ncbi Five oximes (K-27, K-33, K-48, BI-6 and methoxime) in comparison with pralidoxime: survival in rats exposed to the organophosphate paraoxon
    G A Petroianu
    UAE University, Al Ain UAE
    J Appl Toxicol 26:262-8. 2006
    ..The purpose of the study was to quantify in vivo the extent of oxime-conferred protection, using paraoxon (POX) as a cholinesterase inhibitor and to test whether in vitro efficacy translates to protection from mortality...
  56. ncbi New K-Oximes (K-27 and K-48) in Comparison with Obidoxime (LuH-6), HI-6, Trimedoxime (TMB-4), and Pralidoxime (2-PAM): Survival in Rats Exposed IP to the Organophosphate Paraoxon
    G A Petroianu
    United Arab Emirates University, Al Ain United Arab Emirates
    Toxicol Mech Methods 17:401-8. 2007
    ..K-27 and K-48) in male rats with that of obidoxime (LuH-6), trimedoxime (TMB-4), and HI-6, using paraoxon (POX) as a cholinesterase inhibitor. Pralidoxime (2-PAM) was also retested. Seven groups of six rats each were used...
  57. ncbi Intravenous pyruvic acid application in minipigs partially protects acetylcholine-esteratic but not butyrylcholine-esteratic activity in plasma from inhibition by paraoxon
    Georg A Petroianu
    United Arab Emirates University, Faculty of Medicine and Health Sciences, Department of Pharmacology, Al Ain, United Arab Emirates
    J Appl Toxicol 23:37-42. 2003
    Intoxications with organophosphorus compounds such as paraoxon (POX) are frequent. Oximes are the only enzyme reactivators clinically available...
  58. pmc Utilization of mucus from the coral Acropora palmata by the pathogen Serratia marcescens and by environmental and coral commensal bacteria
    Cory J Krediet
    University of Florida, Gainesville, 32611, USA
    Appl Environ Microbiol 75:3851-8. 2009
    ..S. marcescens PDL100 (a pathogen associated with white pox disease of Acroporid corals) grew to higher population densities on components of mucus from the host coral...
  59. ncbi [Influence of different gelatin concentration and lymphocyte isolation liquid on primary culture of umbilical cord blood derived adhesive cells]
    Cheng Zhang
    Department of Hematology, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 16:1437-41. 2008
    ..Cytochemistry stain for nonspecific esterase stain (NSE), peroxidase (POX), periodic acid Schiff reaction (PAS) and alkali phosphatase (ALP) and immunocytochemistry labeling for CD31, CD45, ..
  60. ncbi Pralidoxime and l-lactate effects in vitro on the inhibition of acetylcholinesterase by paraoxon: pralidoxime does not confer superior protection
    G Petroianu
    University of Heidelberg at Mannheim, Department of Pharmacology and Toxicology, Maybach Street 14 16, 68169 Mannheim, Germany
    J Appl Toxicol 21:7-13. 2001
    Intoxication with the organophosphorus compound paraoxon (POX), an inhibitor of serine hydrolases, is frequent...
  61. ncbi Landscape factors influencing the spatial distribution and abundance of mosquito vector Culex quinquefasciatus (Diptera: Culicidae) in a mixed residential-agricultural community in Hawai'i
    Matthew E Reiter
    Research Corporation of the University of Hawai i, 2530 Dole Street, Sakamaki Hall D 100, Honolulu, HI 96822, USA
    J Med Entomol 44:861-8. 2007
    Mosquito-borne avian diseases, principally avian malaria (Plasmodium relictum Grassi and Feletti) and avian pox (Avipoxvirus sp...
  62. doi Quantification of lumpy skin disease virus following experimental infection in cattle
    S Babiuk
    National Centre for Foreign Animal Disease, Winnipeg MB, Canada
    Transbound Emerg Dis 55:299-307. 2008
    Lumpy skin disease along with sheep pox and goatpox are the most serious poxvirus diseases of livestock, and are caused by viruses that belong to the genus Capripoxvirus within the subfamily Chordopoxvirinae, family Poxviridae...
  63. doi Detection of reticuloendotheliosis virus as a contaminant of fowl pox vaccines
    A M Awad
    Department of Avian and Aquatic Animal Medicine, Faculty of Veterinary Medicine, Alexandria University, Behera, Egypt 22758
    Poult Sci 89:2389-95. 2010
    This study was designed to detect reticuloendotheliosis virus (REV) as a contaminant in fowl pox vaccines. A total of 30 fowl pox vaccine samples were examined for the presence of REV using both in vitro and in vivo methods...
  64. pmc N-methylisatin-beta-thiosemicarbazone derivative (SCH 16) is an inhibitor of Japanese encephalitis virus infection in vitro and in vivo
    Liba Sebastian
    Department of Neurovirology, National Institute of Mental Health and Neuro Sciences, Bangalore 560029, India
    Virol J 5:64. 2008
    ..century, several reports described the therapeutic effects of N-methylisatin-beta-Thiosemicarbazone (MIBT) against pox viruses, Maloney leukemia viruses and recently against HIV...
  65. doi Chromatographic analysis of toxic phosphylated oximes (POX): a brief overview
    Christian Becker
    Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany
    Drug Test Anal 2:460-8. 2010
    ..moiety by a nucleophilic attack of the oximate molecule substituting the enzyme and forming a phosphylated oxime (POX)...
  66. ncbi [A transcultural view of neurological and mental pathology in a Tzeltal Maya community of the Altos Chiapas]
    F J Carod
    , San Cristobal de las Casas Chiapas,
    Rev Neurol 24:848-54. 1996
    ..Migraine, "yaxti-wanjol chawaj' is treated with the raw, crushed roots of the herbs "chopak pox' and "bakte pox' together with the practice of cutting the patient with a piece of glass in the temporal region, ..
  67. ncbi The use of transgenic fruit trees as a resistance strategy for virus epidemics: the plum pox (sharka) model
    M Ravelonandro
    Station de Pathologie Vegetale, INRA, Centre de Recherche de Bordeaux, BP 81, 33883 Cedex, Villenave D Ornon, France
    Virus Res 71:63-9. 2000
    Sharka or plum pox, caused by Plum pox virus (PPV: genus Potyvirus; Family Potyviridae), is the most serious disease of Prunus...
  68. ncbi Modification of low-density lipoprotein during radiolabeling with 99mTc using three labeling methods
    G Sobal
    Department of Nuclear Medicine, Medical University of Vienna, Vienna, Austria
    Q J Nucl Med Mol Imaging 50:334-43. 2006
    ..The influence of the LDL sampling methods, isolation, preparation and radiolabeling of lipoproteins on structure modification and the subsequent imaging behavior has as yet not been addressed in detail...
  69. pmc Altered gene expression changes in Arabidopsis leaf tissues and protoplasts in response to Plum pox virus infection
    Mohan Babu
    Southern Crop Protection and Food Research Centre, Agriculture and Agri Food Canada, 1391 Sandford St, London, Ontario, N5V 4T3, Canada
    BMC Genomics 9:325. 2008
    ..ATH1 array was used to assess global gene expression changes in Arabidopsis thaliana plants infected with Plum pox virus (PPV)...
  70. ncbi Altered capillary filtration coefficient in parathion- and paraoxon-induced edema in isolated and perfused rabbit lungs
    A Delaunois
    Department of Pharmacology Pharmacotherapy Toxicology, Faculty of Veterinary Medicine, University of Liege, Belgium
    Toxicol Appl Pharmacol 116:161-9. 1992
    ..in pulmonary endothelium permeability and in microvascular hemodynamics induced by parathion (Pth) and paraoxon (Pox), its active metabolite, were investigated in isolated, perfused rabbit lungs...
  71. ncbi Differentiation of sheep pox and goat poxviruses by sequence analysis and PCR-RFLP of P32 gene
    Madhusudan Hosamani
    Pox virus Laboratory, Division of Virology, Indian Veterinary Research Institute, Mukteswar 263 138, Nainital, Uttaranchal State
    Virus Genes 29:73-80. 2004
    Sheep pox and Goat pox are highly contagious viral diseases of small ruminants. These diseases were earlier thought to be caused by a single species of virus, as they are serologically indistinguishable...
  72. ncbi Humoral immune response impairment following excess vitamin E nutrition in the chick and turkey
    A Friedman
    Department of Animal Sciences, Faculty of Agriculture, Food and Environmental Quality Sciences, Hebrew University of Jerusalem, Rehovot, Israel
    Poult Sci 77:956-62. 1998
    ..Antibodies produced in response to naturally occurring Escherichia coli and to Newcastle disease virus and turkey pox vaccines were determined. In chicks, antibody production in response to E...
  73. ncbi L-lactate reduces in vitro the inhibition of butyrylcholinesterase (BChE) by paraoxon (E 600)
    G Petroianu
    University of Heidelberg at Mannheim, Department of Pharmacology and Toxicology, Mannheim, Germany
    J Appl Toxicol 19:329-36. 1999
    Intoxication with the organophosphorus compound paraoxon (POX), an inhibitor of serine hydrolases, is frequent. Oximes are the only enzyme reactivators clinically available...
  74. pmc Pox proteomics: mass spectrometry analysis and identification of Vaccinia virion proteins
    Jennifer D Yoder
    Oregon State University, Department of Microbiology, 220 Nash Hall, Corvallis, OR 97331 3804, USA
    Virol J 3:10. 2006
    ....
  75. pmc GC content-based pan-pox universal PCR assays for poxvirus detection
    Yu Li
    Centers for Disease Control and Prevention, National Center for Zoonotic, Vector Borne, and Enteric Diseases, Division of Viral and Rickettsial Diseases, Poxvirus and Rabies Branch, Atlanta, Georgia 30329, USA
    J Clin Microbiol 48:268-76. 2010
    ..These pan-pox assays amplify DNA from more than 150 different isolates and strains, including from primary clinical materials, ..
  76. ncbi In vitro protection of plasma cholinesterases by metoclopramide from inhibition by paraoxon
    G Petroianu
    United Arab Emirates University, Faculty of Medicine and Health Sciences Department of Pharmacology, Al Ain, United Arab Emirates
    J Appl Toxicol 23:75-9. 2003
    ..was to quantify "in vitro" by means of the IC(50)-shift the extent of MCP conferred protection, using paraoxon (POX) as an inhibitor...
  77. ncbi Inhibitory efficacy of cyclosal-nucleoside monophosphates of aciclovir and brivudin on DNA synthesis of orthopoxvi ruses
    Andreas Sauerbrei
    Institute of Virology and Antiviral Therapy, University of Jena, Jena, Germany
    Antivir Chem Chemother 17:25-31. 2006
    ..vaccinia and cowpox viruses of several cycloSal-pro-nucleotides of ACV and BVDU, which have proven activity against pox viruses...
  78. ncbi Paraoxon has only a minimal effect on pralidoxime brain concentration in rats
    G A Petroianu
    Department of Pharmacology and Therapeutics, FMHS, United Arab Emirates University, Al Ain, United Arab Emirates
    J Appl Toxicol 27:350-7. 2007
    ..The effect of the organophosphate paraoxon (POX) on pralidoxime (2-PAM) brain entry was therefore determined...
  79. doi Capripoxvirus G-protein-coupled chemokine receptor: a host-range gene suitable for virus animal origin discrimination
    Christian Le Goff
    CIRAD, UMR Contrôle des Maladies, F 34398 Montpellier, France
    J Gen Virol 90:1967-77. 2009
    The genus Capripoxvirus within the family Poxviridae comprises three closely related viruses, namely goat pox, sheep pox and lumpy skin disease viruses...
  80. doi A vero cell derived combined vaccine against sheep pox and Peste des Petits ruminants for sheep
    S S Chaudhary
    Division of Biological Products, Indian Veterinary Research Institute IVRI, P O Izatnagar 243122, UP, India
    Vaccine 27:2548-53. 2009
    The combined sheep pox and Peste des Petits ruminants (PPR) vaccine was prepared in lyophilized form containing recommended doses of both vaccine viruses. Safety and immunogenicity of this combined vaccine was evaluated in sheep...
  81. doi Emerging Capripoxvirus disease outbreaks in Himachal Pradesh, a northern state of India
    S Verma
    Department of Veterinary Microbiology, DGCN COVAS, CSKHPKV, Palampur, Himachal Pradesh, India
    Transbound Emerg Dis 58:79-85. 2011
    Both sheep and goat pox are contagious viral diseases and affect small ruminants and are caused by sheep pox virus and goat pox virus respectively that belong to genus Capripoxvirus of Poxviridae family...
  82. doi Sequence analysis of attachment gene of lumpy skin disease and sheep poxviruses
    A A El-Kenawy
    Departement of Virology, Faculty of Veterinary Medicine Mansoura University, Mansoura 35516, Egypt
    Virol Sin 25:409-16. 2010
    ..In the present study 15 skin nodules from LSD suspected cows and 5 scab samples from sheep pox (SP) suspected sheep were collected...
  83. ncbi Pox in the docks: varicella outbreak in an Australian prison system
    Michael H Levy
    Corrections Health Service, Long Bay Prison Hospital, Matraville, NSW 2036, Australia
    Public Health 117:446-51. 2003
    ..2. Highlight the risks of disease transmission within the prison environment. 3. Promote infection control guidelines for high-risk sub-groups within the prison system, including the application of quarantine...
  84. ncbi Characterization of canarypox-like viruses infecting endemic birds in the Galápagos Islands
    Teresa Thiel
    Department of Biology, University of Missouri St Louis, Missouri 63121, USA
    J Wildl Dis 41:342-53. 2005
    The presence of avian pox in endemic birds in the Galápagos Islands has led to concern that the health of these birds may be threatened by avipoxvirus introduction by domestic birds...
  85. ncbi Mycological examinations on the fungal flora of the chicken comb
    S Grunder
    Department of Dermatology and Andrology, Justus Leibig University Giessen, Giessen, Germany
    Mycoses 48:114-9. 2005
    ..4%) were found to have clinical signs: only non-specific lesions neither typical of mycosis nor of avian pox such as desquamation with crust formation, yellow to brown or black dyschromic changes, alopecia in the surrounding ..
  86. ncbi Necropsy findings and arbovirus surveillance in mourning doves from the southeastern United States
    Richard W Gerhold
    Southeastern Cooperative Wildlife Disease Study, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602, USA
    J Wildl Dis 43:129-35. 2007
    ..Trichomonosis constituted 40% (n = 54) of all diagnoses and was the most frequent diagnosis. Toxicoses and avian pox constituted 18.5% (n = 25) and 14.8% (n = 20) of all diagnoses, respectively...
  87. ncbi Pax: a murine multigene family of paired box-containing genes
    C Walther
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Gottingen, Federal Republic of Germany
    Genomics 11:424-34. 1991
    ..domains, and the three human paired domains shows that they fall into six distinct classes: class I comprises Pox meso, Pax-1, and HuP48; class II paired, gooseberry-proximal, gooseberry-distal, Pax-3, Pax-7, HuP1, and HuP2; ..
  88. ncbi Evidence for incomplete replication of a penguin poxvirus in cells of mammalian origin
    L M Stannard
    Department of Medical Microbiology, University of Cape Town Medical School, South Africa
    J Gen Virol 79:1637-46. 1998
    The recent discovery of a novel poxvirus [penguin-pox virus (PPV)] from Jackass penguins offers the potential of a unique candidate vaccine vector for use in mammals...
  89. ncbi Technology evaluation: CEA-TRICOM, Therion Biologics Corp
    M A Morse
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Curr Opin Mol Ther 3:407-12. 2001
    Therion Biologics, the NCI and Aventis Pasteur are investigating CEA-TRICOM, a recombinant, pox virus-based vaccine that incorporates a triple dose of costimulatory molecules as well as the carcinoembryonic antigen (CEA) tumor antigen, ..
  90. pmc Crystal structure of the fission yeast mitochondrial Holliday junction resolvase Ydc2
    S Ceschini
    Section of Structural Biology, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK
    EMBO J 20:6601-11. 2001
    ..Diverse Holliday junction-resolving enzymes have been identified in bacteria, bacteriophages, archaea and pox viruses, but the only eukaryotic examples identified so far are those from fungal mitochondria...
  91. ncbi Presence of avipoxvirus DNA in avian dermal squamous cell carcinoma
    Luiz C B Fallavena
    Centro de Diagnóstico e Pesquisa em Patologia Aviária, Faculdade de Veterinaria, Universidade Federal do Rio Grande do Sul, Av Bento Gonçalves 8824, Porto Alegre, CEP 91540 000, Rio Grande do Sul, Brazil
    Avian Pathol 31:241-6. 2002
    ..In previous studies, the possibility of the involvement of pox viruses in the cause of DSCC was considered...
  92. ncbi Effect of temperature on plum pox virus infection
    M Glasa
    Department of Plant Viruses, Institute of Virology, Slovak Academy of Sciences, Dubravska cesta 9, 845 05 Bratislava, Slovak Republic
    Acta Virol 47:49-52. 2003
    ..Using five epidemiologically different isolates of Plum pox virus (PPV) we studied the effect of temperature on the virus infectivity, intensity of disease symptoms and virus ..
  93. pmc Novel innate immune functions for galectin-1: galectin-1 inhibits cell fusion by Nipah virus envelope glycoproteins and augments dendritic cell secretion of proinflammatory cytokines
    Ernest L Levroney
    Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA
    J Immunol 175:413-20. 2005
    ..gal-1 did not inhibit fusion triggered by envelope glycoproteins of other viruses, including two retroviruses and a pox virus, but inhibited fusion triggered by envelope glycoproteins of the related Hendra virus and another ..
  94. ncbi Immunohistochemical evaluation of inflammatory infiltrate in the skin and lung of lambs naturally infected with sheeppox virus
    M Y Gulbahar
    University of Ondokuz Mayis, Faculty of Veterinary Medicine, Department of Pathology, Kurupelit, 55200 Samsun, Turkey
    Vet Pathol 43:67-75. 2006
    ..The inflammatory infiltrate in pox lesions in both skin and lung was characterized by the presence of MHC II+ dendritic cells, CD4+, CD8+, gammadelta+ ..
  95. ncbi Gene regulation by hypoxia and the neurodevelopmental origin of schizophrenia
    Rainald Schmidt-Kastner
    Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, Maastricht University, 6200 MD Maastricht, The Netherlands
    Schizophr Res 84:253-71. 2006
    ..AKT1, BDNF, CAPON, CCKAR, CHRNA7, CNR1, COMT, DNTBP1, GAD1, GRM3, IL10, MLC1, NOTCH4, NRG1, NR4A2/NURR1, PRODH, RELN, RGS4, RTN4/NOGO and TNF, are subject to regulation by hypoxia and/or are expressed in the vasculature...
  96. ncbi [Gene polymorphism and gene expression in schizophrenia]
    Trixler Mátyás
    PTE AOK Pszichiatriai es Pszichoterapias Klinika, Pecs
    Psychiatr Hung 21:404-12. 2006
    ..Several susceptibility genes [including COMT, dysbindin, neuregulin, DISCI, RGS4, GRM3, G72, PPP3CC, CHRNA7, PRODH2, Aktl, 5qGABA(A)] having physiological function in the brain have been identified and this supports the view of ..
  97. pmc Complete DNA sequences of two oka strain varicella-zoster virus genomes
    Sueli L Tillieux
    Viral Vaccines Research and Development, GlaxoSmithKline Biologicals, Rue de l Institut, 89 P31 005, B 1330 Rixensart, Belgium
    J Virol 82:11023-44. 2008
    Varicella-zoster virus (VZV) is a herpesvirus and is the causative agent of chicken pox (varicella) and shingles (herpes zoster)...
  98. ncbi Multicolor quantum dot-encoded microspheres for the fluoroimmunoassays of chicken newcastle disease and goat pox virus
    Pingfan Yuan
    Department of Analytical Chemistry, College of Chemistry, Jilin University, Changchun 130012, China
    J Nanosci Nanotechnol 9:3092-8. 2009
    ..Two different antigens, Chicken newcastle disease (CND) antigen and goat pox virus (GPV) antigen, were conjugated to two kinds of biofunctional multicolor microspheres with different optical ..
  99. ncbi Continuous UV-B irradiation induces endoreduplication and peroxidase activity in epidermal cells surrounding trichomes on cucumber cotyledons
    Seiji Yamasaki
    Laboratory of Plant Physiology, Department of Science Education, Faculty of Education, Fukuoka University of Education, Fukuoka 811 4192, Japan
    J Radiat Res 51:187-96. 2010
    ..In epidermal cells surrounding trichomes, UV-B irradiation induced peroxidase (POX) activity from days 7 to 15...
  100. ncbi Status of sheep sera to bluetongue, peste des petits ruminants and sheep pox in a few northern states of India
    Veerakyathappa Bhanuprakash
    Division of Virology, Indian Veterinary Research Institute, Mukteswar 263 138, Nainital Distt, Uttarakhand, India
    Vet Ital 44:527-36. 2008
    Bluetongue (BT), peste des petits ruminants (PPR) and sheep pox are the most economically important viral diseases of sheep in India...

Research Grants62

  1. XVII International Poxvirus, Asfivirus and Indorviurs Symposium
    Bertram L Jacobs; Fiscal Year: 2010
    ..This is the premier meeting for the growing community of researchers working on pox and pox-related viruses and for scientists seeking to learn more about the impact of these viruses on basic and ..
  2. Programming of Protective CD8 T-Cell Memory by Live and Adjuvanted Subunit Vaccin
    Marulasiddappa Suresh; Fiscal Year: 2013
    ..effective in controlling human infections such as smallpox, yellow fever, measles, mumps, rubella, and chicken pox. These live vaccines stimulate robust humoral and cell-mediated immunity that can persist for decades after ..
  3. INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay A Nelson; Fiscal Year: 2012
    ..genital lesions (HSV-2), meningitis and encephalitis (HSV-1 and HSV-2), infectious mononucleosis (EBV), chicken pox and shingles (VZV)...
  4. INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay A Nelson; Fiscal Year: 2011
    ..genital lesions (HSV- 2), meningitis and encephalitis (HSV-1 and HSV-2), infectious mononucleosis (EBV), chicken pox and shingles (VZV)...
  5. INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay A Nelson; Fiscal Year: 2013
    ..genital lesions (HSV-2), meningitis and encephalitis (HSV-1 and HSV-2), infectious mononucleosis (EBV), chicken pox and shingles (VZV)...
  6. INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay A Nelson; Fiscal Year: 2010
    ..genital lesions (HSV- 2), meningitis and encephalitis (HSV-1 and HSV-2), infectious mononucleosis (EBV), chicken pox and shingles (VZV)...
  7. Structure/Function of Varicella Zoster Virus DNA.
    William Ruyechan; Fiscal Year: 2009
    Varicella zoster virus (VZV) is the causative agent of chicken pox and shingles...
  8. Dev. of Optimized/Adjuvanted Smallpox DNA Vaccine (Gene Gun)
    T C Wu; Fiscal Year: 2009
    ..Among the poxvirus-encoded proteins, four membrane proteins (A33R, B5R, L1R and A27L) (called 4-pox vaccine) have been shown to generate protective neutralizing antibody responses and host range protein 2 (HRP2, ..
  9. Mechanisms of pox virus motility and release
    Daniel Kalman; Fiscal Year: 2012
    ..g., FDA-approved Gleevec) limit poxvirus egress and release both in vitro and in vivo, a critical prelude for the potential therapeutic use of Gleevec and related compounds as therapeutics for poxviral infections. ..
  10. N-methanocarbathymidine (N-MCT) for the Treatment of Herpes and Pox Virus Infecti
    Aquilur Rahman; Fiscal Year: 2010
    ..the leading antiviral drugs acyclovir, ganciclovir and cidofovir 5) It is nontoxic at dose producing potent anti-pox virus activity in infected mice, in contrast to the high renal toxicity associated with cidofovir 6) It is active ..
  11. Stage-Specific Inhibitors of Orthopoxviruses
    John H Connor; Fiscal Year: 2012
    ..priority given the threat of smallpox weaponization and the rise in reports of humans infected with monkey pox, which is endemic to Central and Western Africa and was exported to the US in 2003...
  12. Rafi Ahmed; Fiscal Year: 2016
    ..in characterizing human memory T and B cell responses not only to YFV but also after immunization with small pox and influenza vaccines...
  13. Aquilur Rahman; Fiscal Year: 2014
    ..antiviral drug, N- methanocarbathymidine (N-MCT), which has exhibited potent activity against herpes and pox viruses and drug-resistant variants in vivo at doses that are non-cytotoxic in mice, rats, guinea pigs and dogs, ..
  14. MECHANISMS OF DNA REPLICATION AND RECOMBINATION IN HSV-1
    Paul E Boehmer; Fiscal Year: 2010
    ..is one of eight human herpesviruses that are know to cause diverse diseases ranging from cold sores and chicken pox to mononucleosis and even cancer...
  15. Paul D Gershon; Fiscal Year: 2014
    ..The major hole in our knowledge of pox virion structure lies at a level between the inventory of proteins present within the virion (which is largely ..
  16. SEVENTEENTH INTERNATIONAL HERPESVIRUS WORKSHOP
    S Hayward; Fiscal Year: 1992
    ..by herpes simplex (HSV) -1 and -2 respectively, eye ulcerations by HSV, infectious mononucleosis by EBV and chicken pox and shingles by varicella- zoster virus (VZV)...
  17. ASM Conference on Viral Genome Replication
    Sean P J Whelan; Fiscal Year: 2011
    ..The division of virology into DNA vs. RNA, positive-strand RNA vs. negative-strand RNA, herpes vs. pox, picornas vs...
  18. Integrated Microfluidic Platform for Point-of-Care Serodiagnostics
    Xiaowu Liang; Fiscal Year: 2013
    ..tuberculosis, variola major related pox viruses, Dengue, and West Nile)...
  19. The Role of Infection in Childhood Stroke
    Heather J Fullerton; Fiscal Year: 2010
    ..whether infections (recent febrile infection, severe acute infections such as meningitis and remote chicken pox) are risk factors for first childhood stroke;2) to determine whether a history of infection prior to a first stroke ..
  20. 26th Intl Herpesvirus Workshop, Regensburg, Germany
    Jay Nelson; Fiscal Year: 2001
    ..genital lesions (HSV-2), meningitis and encephalitis (HSV-1 and HSV-2), infectious mononucleosis (EBV) chicken pox and shingles (VZV)...
  21. 25TH INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay Nelson; Fiscal Year: 2000
    ..genital lesions (HSV-2), meningitis and encephalitis (HSV-I and HSV-2), infectious mononucleosis (EBV), chicken pox and shingles (VZV)...
  22. International Herpesvirus Workshop, Cairns, Australia
    Jay Nelson; Fiscal Year: 2002
    ..genital lesions (HSV-2), meningitis and encephalitis (HSV-1 and HSV-2), infectious mononucleosis (EBV), chicken pox and shingles (VZV)...
  23. EIGHTEENTH INTERNATIONAL HERPES VIRUS MEETING
    Joseph Glorioso; Fiscal Year: 1993
    ..Varicella-zoster virus (VZV) causes chicken pox and shingles, while Epstein-Barr virus (EBV) is responsible for infectious mononucleosis...
  24. 24TH INTERNATIONAL HERPESVIRUS WORKSHOP
    Frederick Wang; Fiscal Year: 1999
    ..genital lesions (HSV-2), meningitis and encephalitis (HSV-1 and HSV-2), infectious mononucleosis (EBV), chicken pox and shingle (VZV)...
  25. Richard C Condit; Fiscal Year: 2014
    ..In one aim the assembly of the pox virion core will be investigated by performing infections with wild type virus or virus bearing mutations in ..
  26. 15TH INTERNATIONAL HERPESVIRUS WORKSHOP
    LEONARD ROSENTHAL; Fiscal Year: 1990
    ..such as skin and eye ulcerations (HSV-l), genital lesions (HSV-2), infectious mononucleosis (EBV), and chicken pox and shingles (VZV). In neonates congenital CMV infections are a major cause of mental retardation and birth defects...
  27. Therapeutics that target processivity complex proteins of pox and other viruses
    ROBERT PAUL RICCIARDI; Fiscal Year: 2013
    ..Our hope is to develop a unique class of inhibitors that protect against pox and other viral diseases...
  28. PROTECTION AGAINST ORGANOPHOSPHATE NEUROTOXINS BY TOBACCO CEMBRANOIDS
    P A Ferchmin; Fiscal Year: 2010
    ..antidotes development the neuroprotective efficacy of 4R will be tested against two less toxic analogues, paraoxon (POX) and diisopropylfluorophosphate (DFP)...
  29. Development of a therapy for Smallpox, Vaccinia, and Monkeypox
    Alexander Rich; Fiscal Year: 2010
    ..two university laboratories (MIT and Arizona State University), specializing in protein-DNA interactions and in pox virology, plus a not-for-profit institute, Southern Research Institute, skilled in drug discovery and development...
  30. Molecular mechanisms of gammaherpesvirus latency and reactivation
    Douglas White; Fiscal Year: 2009
    ..viruses, including the one that causes cold sores, that infect all humans and cause diseases ranging from chicken pox to cancer...
  31. GENE REGULATION BY VARICELLA ZOSTER VIRUS 140K. PROTEIN
    JOAN BETZ; Fiscal Year: 1992
    Varicella-zoster virus (VZV), the causative agent of chicken pox (varicella) and shingles (zoster), shares with other herpesviruses the ability to cause both productive infections as well as to enter a latent state...
  32. Functional analysis of Phospholipase D4
    David Nemazee; Fiscal Year: 2010
    ..Particularly close homologues to PLD4 are found in pox viruses...
  33. Pathogenesis of Vaccinia virus keratitis
    Curtis R Brandt; Fiscal Year: 2013
    ..In addition, outbreaks of animal pox viruses occasionally occur in humans...
  34. IMMUNITY AND VIRUS DISEASE
    Raymond M Welsh; Fiscal Year: 2013
    ..live with the specter of the re-emergence of a 1918-1ike strain of influenza virus or the release of variola (small pox) virus by bioterrorism...
  35. Smallpox subunit vaccine in the C-PERL expression system
    GEORGE BUCHMAN; Fiscal Year: 2005
    ..process for the production of the subunit vaccine; (2) Completion of a mouse vaccinia challenge model and a monkey pox monkey model using protein produced in the C-PERL larval system; (3) Approval of an IND for testing of the subunit ..
  36. Host responses to smallpox and monkeypox
    David Relman; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Despite the almost unparalleled impact of small pox on human history, our knowledge and understanding of the molecular and cellular biology and the pathophysiology of Variola infection ..
  37. Inhibitors of pox virus Holliday juction resolvase
    Anca Segall; Fiscal Year: 2005
    b>Pox viruses are very wide spread, double stranded DNA viruses that replicate in the cytoplasm of animal, bird and insect hosts...
  38. ORTHOPOXVIRUS GENOMICS AND BIOINFORMATICS RESOURCE CENTE
    R Buller; Fiscal Year: 2003
    ..S. Small pox is highly Contagious and mortality is in the range of 30%. There is no available antiviral therapy...
  39. DNA REPLICATION AND GENE EXPRESSION OF CHLORELLA VIRUSES
    James Van Etten; Fiscal Year: 2009
    ..Thus, chlorella viruses are an important model for studying large nucleocytoplasmic dsDNA viruses because they have evolutionary ties to important mammalian viruses, such as the pox viruses and the quarantined African swine fever virus.
  40. ELKE LIPKA; Fiscal Year: 2014
    ..such as variola as a potential bioterrorism threat, and numerous other DNA viruses, including herpes, adeno, pox, polyoma and papilloma viruses, are of general concern in a public health context, as are the possible emergence of ..
  41. Joseph A Gogos; Fiscal Year: 2014
    ..One cause of hyperprolinemia is loss-of-function mutations of the PRODH gene, which is involved in L-proline degradation. The PRODH gene maps in the 22q11...
  42. SNPs in Handling of Small Pox Antivirals and Other Drugs
    Sanjay Nigam; Fiscal Year: 2009
    ..Ultimately, this work should provide the basis of a useful strategy to diminish renal failure in humans treated with nephrotoxic drugs. ..
  43. Regulation of P. aeruginosa PoxB Oxacillinase by AmpR and a Two-Component System
    Kalai Mathee; Fiscal Year: 2011
    ..Our long-term goal is to establish the regulatory circuit that exists between the amp and pox genes and their role in the development of resistance to [unreadable]-lactams and the establishment of chronic ..
  44. Role of gammaHV68 M1 antigen in Vbeta4+ T cell expansion and fibrosis
    Samuel H Speck; Fiscal Year: 2012
    ..The M1 antigen, which bears sequence homology to some pox virus serpins (although it lacks critical catalytic residues) and to the ?HV68 secreted high affinity chemokine ..
  45. PML antiviral for AIDS
    Milton H Werner; Fiscal Year: 2010
    ..In the present case, the Company has screened its compound portfolio against TB, flu (H5N1), pox, mouse polyoma and herpes viruses and seen in vitro antiviral activity...
  46. Donald F Becker; Fiscal Year: 2015
    ..of proline to glutamate by coordinating the activities of separate flavin-dependent proline dehydrogenase (PRODH) and NAD+-dependent 1-pyrroline- 5-carboxylate dehydrogenase (P5CDH) domains...
  47. Stephen M Hedrick; Fiscal Year: 2015
    ..We propose that the absence of Caspase-8 is a molecular signature of viral infection, e. g., herpes family or pox family viruses, and as a counter defense, vertebrates have evolved a parallel pathway of cell death...
  48. Greg S B Suh; Fiscal Year: 2016
    ..Indeed, my laboratory showed that the Drosophila mutants - GR5a;GR64a and pox-neuro mutants - that are insensitive to the taste of sugar still developed a preference for a sugar solution based ..
  49. Training Program in Viral Replication
    Laimonis A Laimins; Fiscal Year: 2013
    ..Emerging viruses such as SARS, West Nile, monkey pox, and Ebola and the threat ofthe use of viruses as agents of bioterrorism create substantial need for the training ..
  50. Vidarabine Prodrugs as Anti-Pox Virus Agents
    John Hilfinger; Fiscal Year: 2007
    ..targeted research and development of therapeutics, vaccines, adjuvants/immunostimulants, and diagnostics for small pox and other viral diseases. At TSRL, Inc...
  51. Biosurveillance Utilizing SNOMED-CT Based Natural Language Processing
    Peter Elkin; Fiscal Year: 2007
    ..e. Anthrax, Small Pox, Ricin, and Radiation exposure)...
  52. SPECTROSCOPIC STUDIES OF ENZYME/SUBSTRATE COMPLEXES
    George Reed; Fiscal Year: 2007
    ..of the microbial pyruvate metabolizing enzymes, pyruvate:ferredoxin oxidoreductase (PFOR) and pyruvate oxidase (POX)...
  53. Choosing Drug Doses for Biodefense Pathogens
    George Drusano; Fiscal Year: 2009
    ..of drugs to treat patients infected with the Bioterror pathogens Bacillus anthracis, Yersinia pestis and the Pox viruses Vaccinia Virus and Cowpox Virus...
  54. Improving Absorption and Targeting of Antiviral Drugs
    John Hilfinger; Fiscal Year: 2009
    ..long-term goal of this project for biodefense is to improve the oral absorption of potent, but poorly absorbed anti-pox agents by designing prodrugs targeted to transporters expressed in human intestine and able to be activated by ..
  55. Improving Absorption and Targeting of Antiviral Drugs
    John Hilfinger; Fiscal Year: 2004
    ..targeted research and development of therapeutics, vaccines, adjuvants/immunostimulants, and diagnostics for small pox and other viral diseases. At TSRL, Inc...
  56. VIRUS CHROMOSOME STRUCTURE: ROLE IN DEVELOPMENT
    Michael Feiss; Fiscal Year: 2005
    ..Lambda is an excellent model system for studying virion assembly for the large DNA viruses, including the herpes, pox and adenoviruses. These viruses assemble empty protein shells into which the viral chromosome is packaged...
  57. Iron Trafficking to Ribonucleotide Reductases
    DANIEL KOSMAN; Fiscal Year: 2006
    ..reductase (RR) is essential to genome replication of mammals and the large DNA viruses that they host (pox, herpes, and adenoviruses)...
  58. Therapeutics for Pox, Filo and Other Viral Pathogens
    STEWART SCHNELLER; Fiscal Year: 2007
    ..Because of the extensive collaborations that have been ongoing for some time by this group of chemists and virologists, it can be expected that promising anti-orthopoxvirus and anti-filovirus agents will be uncovered. ..
  59. SELENOPROTEINS, NF-KB, AND HIV DISEASE IN IV DRUG USERS
    ETHAN TAYLOR; Fiscal Year: 2003
    ..Significantly, some viruses, including a pox virus and HIV-1 (our preliminary data), encode homologues of glutathione peroxidase (GPx), the prototypical ..
  60. Rapid Diagnosis of Monkeypox and Smallpox Infections
    MARK SLIFKA; Fiscal Year: 2005
    ..In Specific Aim II, we will identify "pan-pox" reagents capable of identifying any recent infection with the major orthopoxviruses known to cause human disease...
  61. REGULATION OF NATURAL KILLER CELLS
    Raymond Welsh; Fiscal Year: 2005
    ..that gammas T cells become activated and control infections with vaccinia virus (VV), which is used for human small pox vaccination...
  62. Biology of Single Activity PGH Synthases
    COLIN FUNK; Fiscal Year: 2004
    ..PGHS isozymes are bifunctional, with a cyclooxygenase (COX) activity and a functionally linked peroxidase (POX) activity...