PRKCQ

Summary

Gene Symbol: PRKCQ
Description: protein kinase C theta
Alias: PRKCT, nPKC-theta, protein kinase C theta type
Species: human

Top Publications

  1. pmc Shared and distinct genetic variants in type 1 diabetes and celiac disease
    Deborah J Smyth
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    N Engl J Med 359:2767-77. 2008
  2. pmc Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes
    K Conant
    Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA
    J Virol 70:1384-9. 1996
  3. pmc Novel antileukemic compound ingenol 3-angelate inhibits T cell apoptosis by activating protein kinase Ctheta
    Wing Yiu Lee
    Medical Research Council, Centre for Immune Regulation, Institute for Biomedical Research, School of Immunity and Infection, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Biol Chem 285:23889-98. 2010
  4. pmc Protein kinase C (PKC) activity regulates functional effects of Kvβ1.3 subunit on KV1.5 channels: identification of a cardiac Kv1.5 channelosome
    Miren David
    Instituto de Investigaciones Biomedicas, Madrid Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid, c Arturo Duperier 4, 28029 Madrid, Spain
    J Biol Chem 287:21416-28. 2012
  5. pmc Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci
    Jason D Cooper
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Nat Genet 40:1399-401. 2008
  6. ncbi 14-3-3Gamma interacts with and is phosphorylated by multiple protein kinase C isoforms in PDGF-stimulated human vascular smooth muscle cells
    M V Autieri
    Department of Cardiology and Physiology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    DNA Cell Biol 18:555-64. 1999
  7. ncbi Inhibition of protein kinase C and anti-CD3-induced Ca2+ influx in Jurkat T cells by a synthetic peptide with sequence identity to HIV-1 gp41
    C L Ruegg
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    J Immunol 144:3928-35. 1990
  8. ncbi In vitro phosphorylation of human immunodeficiency virus type 1 Tat protein by protein kinase C: evidence for the phosphorylation of amino acid residue serine-46
    A M Holmes
    Biochemistry Department, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Arch Biochem Biophys 335:8-12. 1996
  9. ncbi Inhibition of the c-Jun N-terminal kinase/AP-1 and NF-kappaB pathways by PICOT, a novel protein kinase C-interacting protein with a thioredoxin homology domain
    S Witte
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Biol Chem 275:1902-9. 2000
  10. pmc Tat protein of human immunodeficiency virus type 1 induces interleukin-10 in human peripheral blood monocytes: implication of protein kinase C-dependent pathway
    A Badou
    Laboratoire d Immuno Virologie EA3038, Universite Paul Sabatier, 31062 Toulouse Cedex, France
    J Virol 74:10551-62. 2000

Research Grants

  1. ANGARA KONETI RAO; Fiscal Year: 2016
  2. ANTIOXIDANTS AND FEMALE HORMONES IN THE ETIOLOGY OF RA
    Elizabeth Karlson; Fiscal Year: 2002
  3. Protective Mechanism of an Anti-Inflammatory Herbal Mix
    Ali Banan; Fiscal Year: 2006
  4. EGF, Oxidants & Intestinal Barrier Integrity
    Ali Banan; Fiscal Year: 2006

Scientific Experts

Detail Information

Publications141 found, 100 shown here

  1. pmc Shared and distinct genetic variants in type 1 diabetes and celiac disease
    Deborah J Smyth
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    N Engl J Med 359:2767-77. 2008
    ..Since both diseases are associated with the HLA class II genes on chromosome 6p21, we tested whether non-HLA loci are shared...
  2. pmc Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes
    K Conant
    Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA
    J Virol 70:1384-9. 1996
    ..These effects include Tat's ability to upregulate the synthesis of specific cytokines and to act as a growth factor...
  3. pmc Novel antileukemic compound ingenol 3-angelate inhibits T cell apoptosis by activating protein kinase Ctheta
    Wing Yiu Lee
    Medical Research Council, Centre for Immune Regulation, Institute for Biomedical Research, School of Immunity and Infection, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Biol Chem 285:23889-98. 2010
    ....
  4. pmc Protein kinase C (PKC) activity regulates functional effects of Kvβ1.3 subunit on KV1.5 channels: identification of a cardiac Kv1.5 channelosome
    Miren David
    Instituto de Investigaciones Biomedicas, Madrid Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid, c Arturo Duperier 4, 28029 Madrid, Spain
    J Biol Chem 287:21416-28. 2012
    ..5, K(v)β1.3, the receptor for activated C kinase (RACK1), PKCβI, PKCβII, and PKCθ in HEK293 cells. A very similar K(v)1.5 channelosome was found in rat ventricular tissue but not in atrial tissue...
  5. pmc Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci
    Jason D Cooper
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Nat Genet 40:1399-401. 2008
    ..7 x 10(-12)), 10p15 (PRKCQ, P = 3.7 x 10(-9)), 15q24 (CTSH, P = 3.2 x 10(-15)) and 22q13 (C1QTNF6, P = 2.0 x 10(-8)).
  6. ncbi 14-3-3Gamma interacts with and is phosphorylated by multiple protein kinase C isoforms in PDGF-stimulated human vascular smooth muscle cells
    M V Autieri
    Department of Cardiology and Physiology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    DNA Cell Biol 18:555-64. 1999
    ..Thus, 14-3-3gamma may represent a signal transduction protein that is regulated transcriptionally and post-transcriptionally by growth factors...
  7. ncbi Inhibition of protein kinase C and anti-CD3-induced Ca2+ influx in Jurkat T cells by a synthetic peptide with sequence identity to HIV-1 gp41
    C L Ruegg
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    J Immunol 144:3928-35. 1990
    ....
  8. ncbi In vitro phosphorylation of human immunodeficiency virus type 1 Tat protein by protein kinase C: evidence for the phosphorylation of amino acid residue serine-46
    A M Holmes
    Biochemistry Department, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Arch Biochem Biophys 335:8-12. 1996
    ..Several Tat peptides, containing serine at position 46, are the only ones which are phosphorylated at significant rates. Several other Tat peptides containing potential protein kinase C phosphorylation sites are not phosphorylated...
  9. ncbi Inhibition of the c-Jun N-terminal kinase/AP-1 and NF-kappaB pathways by PICOT, a novel protein kinase C-interacting protein with a thioredoxin homology domain
    S Witte
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Biol Chem 275:1902-9. 2000
    ..These findings suggest that PICOT and its evolutionary conserved homologues may interact with PKC-related kinases in multiple organisms and, second, that it plays a role in regulating the function of the thioredoxin system...
  10. pmc Tat protein of human immunodeficiency virus type 1 induces interleukin-10 in human peripheral blood monocytes: implication of protein kinase C-dependent pathway
    A Badou
    Laboratoire d Immuno Virologie EA3038, Universite Paul Sabatier, 31062 Toulouse Cedex, France
    J Virol 74:10551-62. 2000
    ..This production of IL-10 induced by Tat could participate in the progression of HIV infection to AIDS...
  11. ncbi Involvement of protein kinase C in HIV-1 gp120-induced apoptosis in primary endothelium
    M B Huang
    Department of Biochemistry, Morehouse School of Medicine, Atlanta, Georgia 30310 1495, USA
    J Acquir Immune Defic Syndr 25:375-89. 2000
    ....
  12. ncbi Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells
    G Baier
    La Jolla Institute for Allergy and Immunology, California 92037
    J Biol Chem 268:4997-5004. 1993
    ..Thus, PKC theta represents an additional member of the PKC family, and its predominant expression in hematopoietic cells suggests that it may play a role in signal transduction and growth regulatory pathways unique to these cells...
  13. ncbi Selective modulation of protein kinase C-theta during T-cell activation
    C R Monks
    Division of Basic Sciences, National Jewish Center for Immunology, Denver, Colorado 80206, USA
    Nature 385:83-6. 1997
    ..Several modes of partial T-cell activation that failed to cause PKC-theta translocation also failed to cause T-cell proliferation, further suggesting the involvement of PKC-theta in T-cell activation...
  14. ncbi Protein kinase C-theta phosphorylation of moesin in the actin-binding sequence
    S F Pietromonaco
    Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
    J Biol Chem 273:7594-603. 1998
    ..It appears likely that this activity corresponds to a specific intracellular pathway controlling the function of moesin as well as other ERM proteins...
  15. ncbi Regulation of protein kinase Ctheta function during T cell activation by Lck-mediated tyrosine phosphorylation
    Y Liu
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Biol Chem 275:3603-9. 2000
    ..These results suggest that Lck plays an important role in tyrosine phosphorylation of PKCtheta, which may in turn modulate the physiological functions of PKCtheta during TCR-induced T cell activation...
  16. pmc NF-kappa B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-theta
    N Coudronniere
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 97:3394-9. 2000
    ..These findings identify a unique PKCtheta-mediated pathway for the costimulatory action of CD28, which involves activation of the IkappaB-kinase beta/IkappaB/NF-kappaB-signaling cascade...
  17. ncbi Vav synergizes with protein kinase C theta to mediate IL-4 gene expression in response to CD28 costimulation in T cells
    S P Hehner
    Tumor Immunology Program, German Cancer Research Center DKFZ, Heidelberg, Germany
    J Immunol 164:3829-36. 2000
    ..Vav/PKC theta-induced transcription from the IL-4 promoter was almost completely abrogated by mutation of either the P1 or the PRE-I element within the entire IL-4 promoter...
  18. ncbi PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes
    Z Sun
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York 10016, USA
    Nature 404:402-7. 2000
    ..These results indicate that PKC-theta functions in a unique pathway that links the TCR signalling complex to the activation of NF-kappaB in mature T lymphocytes...
  19. ncbi Complex formation and cooperation of protein kinase C theta and Akt1/protein kinase B alpha in the NF-kappa B transactivation cascade in Jurkat T cells
    B Bauer
    Department of Medical Biology and Human Genetics, University of Innsbruck, A 6020 Innsbruck, Austria
    J Biol Chem 276:31627-34. 2001
    ..Taken together, these findings suggest a direct cross-talk between PKC theta and Akt1 in Jurkat T cells...
  20. pmc Phosphorylation of the protein kinase C-theta activation loop and hydrophobic motif regulates its kinase activity, but only activation loop phosphorylation is critical to in vivo nuclear-factor-kappaB induction
    Yin Liu
    Experimental Immunology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Biochem J 361:255-65. 2002
    ..These findings expand our understanding of the roles of phosphorylation in novel PKCs, and indicate that PKC-theta is a constitutively competent kinase as a consequence of constitutive phosphorylation of its activation loop...
  21. pmc CD28 plays a critical role in the segregation of PKC theta within the immunologic synapse
    Jianyong Huang
    Division of Immunochemistry, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 99:9369-73. 2002
    ....
  22. pmc CD3/CD28 costimulation-induced NF-kappaB activation is mediated by recruitment of protein kinase C-theta, Bcl10, and IkappaB kinase beta to the immunological synapse through CARMA1
    Donghai Wang
    Department of Microbiology and Immunology, School of Medicine and Biomedical Sciences, University at Buffalo, SUNY, Buffalo, New York 14214, USA
    Mol Cell Biol 24:164-71. 2004
    ..Together, these results indicate that CARMA1 mediates CD3/CD28 costimulation-induced NF-kappaB activation by recruiting downstream signaling components into the immunological synapse...
  23. pmc Diacylglycerol-dependent binding recruits PKCtheta and RasGRP1 C1 domains to specific subcellular localizations in living T lymphocytes
    Silvia Carrasco
    Department of Immunology and Oncology, National Center for Biotechnology, Consejo Superior de Investigaciones Cientificas, Campus de Cantoblanco, E 28049 Madrid, Spain
    Mol Biol Cell 15:2932-42. 2004
    ..This is shown by analyzing the contribution of these two lipid pools to PLC-dependent Ras activation in response to TCR triggering...
  24. ncbi PKC theta mediates pre-TCR signaling and contributes to Notch3-induced T-cell leukemia
    Maria Pia Felli
    Department of Experimental Medicine and Pathology, University La Sapienza, 00161 Roma, Italy
    Oncogene 24:992-1000. 2005
    ..This paper therefore suggests that PKC theta mediates the activation of NF-kappa B by pre-TCR in immature thymocytes and contributes to the development of Notch3-dependent T-cell lymphoma...
  25. ncbi PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation
    Ki Young Lee
    Section of Immunobiology and Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 308:114-8. 2005
    ..Hence, PDK1 plays a critical role by nucleating the TCR-induced NF-kappaB activation pathway in T cells...
  26. ncbi Stimulus-induced phosphorylation of PKC theta at the C-terminal hydrophobic-motif in human T lymphocytes
    Michael Freeley
    Department of Biochemistry, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland
    Biochem Biophys Res Commun 334:619-30. 2005
    ..However, hydrophobic-motif phosphorylation does not appear to control membrane translocation, suggesting that this site may control other aspects of PKC theta signalling...
  27. ncbi Protein kinase C-theta is an early survival factor required for differentiation of effector CD8+ T cells
    Rina Barouch-Bentov
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 175:5126-34. 2005
    ....
  28. pmc Critical role of novel Thr-219 autophosphorylation for the cellular function of PKCtheta in T lymphocytes
    Nikolaus Thuille
    Department for Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck, Austria
    EMBO J 24:3869-80. 2005
    ..We conclude that autophosphorylation of PKCtheta at Thr-219 plays an important role in the correct targeting and cellular function of PKCtheta upon antigen receptor ligation...
  29. ncbi Differential roles of PKC-theta in the regulation of intracellular calcium concentration in primary T cells
    Santhakumar Manicassamy
    Department of Microbiology and Immunology, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    J Mol Biol 355:347-59. 2006
    ..Thus, PKC-theta can both positively and negatively regulate the Ca2+ influx that is critical for NFAT activity...
  30. ncbi Phosphorylation of the CARMA1 linker controls NF-kappaB activation
    Karen Sommer
    Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Immunity 23:561-74. 2005
    ..This PKC-dependent switch regulates accessibility of the CARD and CC domains and controls assembly and full activation of the membrane-associated IkappaB kinase (IKK) signalosome...
  31. ncbi Phosphorylation of CARMA1 plays a critical role in T Cell receptor-mediated NF-kappaB activation
    Reiko Matsumoto
    Department of Molecular and Cellular Oncology, University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Immunity 23:575-85. 2005
    ..Together, our studies provide the first genetic evidence that the phosphorylation of CARMA1 plays a critical role in the TCR signaling pathway...
  32. ncbi Protein kinase C-theta-mediated signals enhance CD4+ T cell survival by up-regulating Bcl-xL
    Santhakumar Manicassamy
    Department of Microbiology and Immunology, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    J Immunol 176:6709-16. 2006
    ..Thus, the PKC-theta-mediated signals may function not only in the initial activation of naive CD4+ T cells, but also in their survival during T cell activation by regulating Bcl-xL levels through NF-kappaB and AP-1 pathways...
  33. pmc Novel role for mitochondria: protein kinase Ctheta-dependent oxidative signaling organelles in activation-induced T-cell death
    Marcin Kaminski
    Tumor Immunology Program, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Mol Cell Biol 27:3625-39. 2007
    ..Similar results were obtained when metformin, an antidiabetic drug and mild complex I inhibitor, was used. Thus, we demonstrate for the first time that PKCtheta-dependent ROS generation by mitochondrial complex I is essential for AICD...
  34. pmc Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways
    Prashant B Shambharkar
    Department of Molecular and Cellular Oncology, University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    EMBO J 26:1794-805. 2007
    ..Thus, our study provides the biochemical and genetic evidence that phosphorylation of IKKalpha/beta and ubiquitination of NEMO are regulated by two distinct pathways upon TCR stimulation...
  35. ncbi Mechanism of diacylglycerol-induced membrane targeting and activation of protein kinase Ctheta
    Heather R Melowic
    Department of Chemistry, University of Illinois, Chicago, Illinois 60607, USA
    J Biol Chem 282:21467-76. 2007
    ..Collectively, these results show that PKC has a unique membrane binding and activation mechanism that may account for its subcellular targeting properties...
  36. pmc Protein kinase C-theta regulates KIT expression and proliferation in gastrointestinal stromal tumors
    W B Ou
    1Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Oncogene 27:5624-34. 2008
    ..These novel findings highlight that PKCtheta warrants clinical evaluation as a potential therapeutic target in GISTs, including those cases containing mutations that confer resistance to KIT/PDGFRA kinase inhibitors...
  37. pmc Common variants at CD40 and other loci confer risk of rheumatoid arthritis
    Soumya Raychaudhuri
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nat Genet 40:1216-23. 2008
    ..0035 replication, P = 1.1 x 10(-7) overall), CDK6 (rs42041, P = 0.010 replication, P = 4.0 x 10(-6) overall), PRKCQ (rs4750316, P = 0.0078 replication, P = 4.4 x 10(-6) overall), and KIF5A-PIP4K2C (rs1678542, P = 0...
  38. doi PKC-theta selectively controls the adhesion-stimulating molecule Rap1
    Thomas Letschka
    Department for Medical Genetics, Innsbruck Medical University, Innsbruck, Austria
    Blood 112:4617-27. 2008
    ..Taken together, PKC- theta sets the threshold for T-cell activation by positively regulating both the cytokine responses and the adhesive capacities of T lymphocytes...
  39. pmc T cell-dendritic cell immunological synapses contain TCR-dependent CD28-CD80 clusters that recruit protein kinase C theta
    Su Yi Tseng
    Program in Molecular Pathogenesis, Helen L and Martin S Kimmel Center for Biology and Medicine of the Skirball Institute of Biomolecular Medicine and Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 181:4852-63. 2008
    ..Thus, the T cell-DC interface contains dynamic costimulatory foci that share characteristics of microclusters and cSMACs...
  40. pmc Protein kinase C-theta mediates negative feedback on regulatory T cell function
    Alexandra Zanin-Zhorov
    Molecular Pathogenesis Program, Helen and Martin Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    Science 328:372-6. 2010
    ..Treg freed of PKC-theta-mediated inhibition can function in the presence of inflammatory cytokines and thus have therapeutic potential in control of inflammatory diseases...
  41. ncbi HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication
    Alison L Greenway
    Macfarlane Burnet Institute for Medical Research and Public Health, Cnr Commercial and Punt Roads, Melbourne, Victoria 3004, Australia
    J Biosci 28:323-35. 2003
    ....
  42. ncbi PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta
    Kelly Ann Sheppard
    Inflammation Department, Wyeth Research, 87 Cambridge Park Drive, Cambridge, MA 02140, USA
    FEBS Lett 574:37-41. 2004
    ....
  43. ncbi Developmental regulation of a protein kinase C isoform localized in the neuromuscular junction
    L Hilgenberg
    Department of Anatomy and Cell Biology, State University of New York Health Science Center at Brooklyn 11203, USA
    J Cell Sci 108:51-61. 1995
    ..The message encoding the nPKC theta isoform, a member of the novel calcium-independent class of PKCs, has recently been shown to be abundant in ..
  44. pmc Improved insulin sensitivity by calorie restriction is associated with reduction of ERK and p70S6K activities in the liver of obese Zucker rats
    Yanbin Zheng
    Section of Endocrinology, The University of Chicago, 900 E 57th Street, KCBD Room 8122, Chicago, Illinois 60637, USA
    J Endocrinol 203:337-47. 2009
    ..glycogen synthase kinase 3beta (GSK3B), AMPK (PRKAA1 as listed in the MGI Database), and protein kinase C (PRKCQ) in liver tissue extracts was measured by an in vitro kinase assay using various glutathione-S-transferase (GST)-..
  45. ncbi Overexpression of nPKC theta is inhibitory for agrin-induced nicotinic acetylcholine receptor clustering in C2C12 myotubes
    Kathryn Miles
    Department of Anatomy and Cell Biology, State University of New York Health Science Center at Brooklyn, Brooklyn, New York 11203, USA
    J Neurosci Res 71:188-95. 2003
    ..To address the question whether nPKC theta, a specific PKC isoform restricted in expression to skeletal muscle and localized to neuromuscular junctions, ..
  46. pmc Localization of the fourth locus (GLC1E) for adult-onset primary open-angle glaucoma to the 10p15-p14 region
    M Sarfarazi
    Department of Surgery, University of Connecticut Health Center, Farmington, CT 06030 1110, USA
    Am J Hum Genet 62:641-52. 1998
    ..A partial list of genes that positionally are considered as candidates includes NET1, PRKCT, ITIH2, IL2RA, IL15RA, IT1H2, hGATA3, the mRNA for open reading frame KIAA0019, and the gene for D123 protein.
  47. doi Unraveling the genetics of complex diseases: susceptibility genes for rheumatoid arthritis and psoriasis
    Yonghong Li
    Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
    Semin Immunol 21:318-27. 2009
    ..for at least ten non-HLA related risk genes or loci (C5/TRAF1, CD40, CTLA4, KIF5A/PIP4K2C, MMEL1/TNFRSF14, PADI4, PRKCQ, PTPN22, STAT4, and TNFAIP3/OLIG3) for RA and six (IL12B, IL13, IL23R, STAT2/IL23A, TNFAIP3, and TNIP1) for ..
  48. doi Genetics in neuroendocrine immunology: implications for rheumatoid arthritis and osteoarthritis
    Klaus Stark
    Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany
    Ann N Y Acad Sci 1193:10-4. 2010
    ..susceptibility genes like HLA-DRB1, PTPN22, STAT4, TRAF1/C5, OLIG3/TNFAIP3, CD40, CCL21, MMEL1-TNFRSF14, CDK6, PRKCQ, IL2RB, and KIF5A-PIP4K2C. These association signals explain more than 50% of the genetic influence on RA...
  49. pmc A new member of the protein kinase C family, nPKC theta, predominantly expressed in skeletal muscle
    S Osada
    Department of Molecular Biology, Tokyo Metropolitan Institute of Medical Science, Japan
    Mol Cell Biol 12:3930-8. 1992
    ..This cDNA encodes a protein, nPKC theta, which consists of 707 amino acid residues and showed the highest sequence similarity to nPKC delta (67...
  50. ncbi Induction of thymocyte apoptosis by Ca2+-independent protein kinase C (nPKC) activation and its regulation by calcineurin activation
    A Asada
    Integrative Projects, Mitsubishi Kasei Institute of Life Sciences, 11 Minamiooya, Machida shi, Tokyo 194, Japan
    J Biol Chem 273:28392-8. 1998
    ..These results indicate that activation of nPKC, especially nPKC-theta, induces apoptosis in thymocytes and that calcineurin activation regulates the apoptosis...
  51. doi Common and different genetic background for rheumatoid arthritis and coeliac disease
    Marieke J H Coenen
    Department of Human Genetics, Institute for Genetic and Metabolic Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Hum Mol Genet 18:4195-203. 2009
    ..Dutch and UK data sets, shared association with six loci (TNFAIP3, IL2/IL21, SH2B3, LPP, MMEL1/TNFRSF14 and PFKFB3/PRKCQ) was observed in both RA and CD cohorts...
  52. ncbi Mapping of the human protein kinase C-theta (PRKCQ) gene locus to the short arm of chromosome 10 (10p15) by FISH
    M Erdel
    Institute for Medical Biology and Human Genetic, University of Innsbruck, Austria
    Genomics 25:595-7. 1995
  53. ncbi Inhibition of protein kinase C by a synthetic peptide corresponding to cytoplasmic domain residues 828-848 of the human immunodeficiency virus type 1 envelope glycoprotein
    N E Ward
    Department of Cell Biology, University of Texas M D Anderson Cancer Center, Houston 77030
    Cancer Lett 88:37-40. 1995
    ....
  54. ncbi Regulation of HIV-1 gag protein subcellular targeting by protein kinase C
    G Yu
    Laboratory of Biological Chemistry, National Cancer Institute, NIH, Bethesda, Maryland 20892 4255
    J Biol Chem 270:4792-6. 1995
    ..This signal may provide a mechanism for the cellular regulation of virus development through modulation of gag protein-related developmental steps such as capsid targeting, assembly, encapsidation, budding, and maturation...
  55. pmc Direct interaction between protein kinase C theta (PKC theta) and 14-3-3 tau in T cells: 14-3-3 overexpression results in inhibition of PKC theta translocation and function
    N Meller
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Mol Cell Biol 16:5782-91. 1996
    ..The interaction between 14-3-3 and PKC theta may represent an important general mechanism for regulating PKC-dependent signals and, more specifically, PKC theta-mediated functions during T-cell activation...
  56. ncbi Caspase-3-mediated cleavage of protein kinase C theta in induction of apoptosis
    R Datta
    Division of Cancer Pharmacology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 272:20317-20. 1997
    ..These findings indicate that proteolytic cleavage of PKCtheta by Caspase-3 induces events characteristic of apoptosis...
  57. ncbi HIV-1 Tat protein induces interleukin-10 in human peripheral blood monocytes: involvement of protein kinase C-betaII and -delta
    Yamina Bennasser
    Laboratoire d Immuno Virologie, EA 3038, Universite Paul Sabatier, 31062 Toulouse, France
    FASEB J 16:546-54. 2002
    ..Altogether, these results suggest that the induction of IL-10 by Tat is strictly dependent on the PKC-delta and -betaII isoforms...
  58. pmc Translocation of PKC[theta] in T cells is mediated by a nonconventional, PI3-K- and Vav-dependent pathway, but does not absolutely require phospholipase C
    Martin Villalba
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Cell Biol 157:253-63. 2002
    ..These results provide evidence that a nonconventional PI3-K- and Vav-dependent pathway mediates the selective membrane recruitment and, possibly, activation of PKCtheta in T cells...
  59. ncbi The interaction of protein kinase C isozymes alpha, iota, and theta with the cytoplasmic domain of L-selectin is modulated by phosphorylation of the receptor
    Karin Kilian
    Institut fur Klinische Chemie und Pathobiochemie, Charite, Berlin 12200, Germany
    J Biol Chem 279:34472-80. 2004
    ..The phosphorylation-regulated association of PKC isozymes with the cytoplasmic domain of L-selectin indicates an important role of this kinase family in L-selectin signal transduction...
  60. ncbi Menin represses JunD transcriptional activity in protein kinase C theta-mediated Nur77 expression
    Hyungsoo Kim
    Department of Biochemistry and Molecular Biology, Cancer Research Institute, Seoul National University, College of Medicine, 28 Yongon Dong, Chongro Gu, Seoul 110 799, Korea
    Exp Mol Med 37:466-75. 2005
    ..In fact, Menin represses PKCtheta/p300-mediated transcriptional activity of JunD in T cell. Its dynamic regulation of histone modifiers with JunD is responsible for PKCq-synergistic effect on Nur77 expression in T cell...
  61. ncbi Sulfated polymannuroguluronate, a novel anti-acquired immune deficiency syndrome drug candidate, decreased vulnerability of PC12 cells to human immunodeficiency virus tat protein through attenuating calcium overload
    Bin Hui
    Department of Pharmacology, Marine Drug and Food Institute, Ocean University of China, Qingdao, China
    J Neurosci Res 86:1169-77. 2008
    ..These data demonstrate that SPMG might serve as a valuable therapeutic intervention for Tat-induced neuronal cell death and the subsequent pathologic events of HAD...
  62. ncbi Induction of HIV transcription by Nef involves Lck activation and protein kinase C theta raft recruitment leading to activation of ERK1/2 but not NF kappa B
    Vanessa Witte
    Otto von Guericke University of Magdeburg, Institute of Molecular and Clinical Immunology, Magdeburg, Germany
    J Immunol 181:8425-32. 2008
    ..Instead, we observed an increase in ERK MAPK activity. We conclude that Nef-mediated signaling cooperates with Nef-induced derepression and supports HIV transcription through an ERK MAPK-dependent, but NFkappaB-independent, pathway...
  63. pmc Kit K641E oncogene up-regulates Sprouty homolog 4 and trophoblast glycoprotein in interstitial cells of Cajal in a murine model of gastrointestinal stromal tumours
    Petra Gromova
    Laboratory of Neurophysiology, Faculty of Medicine, Universite Libre de Bruxelles ULB, Brussels, Belgium
    J Cell Mol Med 13:1536-48. 2009
    ..Gja1/Cx43, Gpc6, Gpr133, Pacrg, Pde3a, Prkar2b, Prkcq/Pkce, Rasd2, Spry4 and Tpbg/5T4 were found to be up-regulated...
  64. pmc REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis
    Peter K Gregersen
    The Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY, USA
    Nat Genet 41:820-3. 2009
    ..properties in hematopoietic cells, and its association with rheumatoid arthritis suggests disease pathways that involve other recently identified rheumatoid arthritis susceptibility genes including CD40, TRAF1, TNFAIP3 and PRKCQ.
  65. pmc Association between type 1 diabetes and GWAS SNPs in the southeast US Caucasian population
    M V Prasad Linga Reddy
    Center for Biotechnology and Genomic Medicine, and Department of Pathology, Medical College of Georgia, Augusta, GA 30912, USA
    Genes Immun 12:208-12. 2011
    ..Analysis of the samples identified 18 SNPs (PTPN22, INS, IFIH1, SH2B3, ERBB3, CTLA4, C14orf181, CTSH, CLEC16A, CD69, ITPR3, C6orf173, SKAP2, PRKCQ, RNLS, IL27, SIRPG and CTRB2) with putative association.
  66. doi Gastrointestinal stromal tumors (GISTs): CD117, DOG-1 and PKCθ expression. Is there any advantage in using several markers?
    M J Ríos-Moreno
    Servicio de Anatomia Patologica, Hospital Universitario Virgen Macarena, Seville, Spain
    Pathol Res Pract 208:74-81. 2012
    ..Although PKCθ was less sensitive, and its staining is more challenging and difficult to interpret, the use of this marker is highly recommended, particularly in CD117-negative/DOG-1-negative GISTs...
  67. pmc A genome-wide association study of bronchodilator response in asthmatics
    Q L Duan
    Channing Division of Network Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Pharmacogenomics J 14:41-7. 2014
    ..51 × 10(-6)). This study applied a robust approach for testing the genetic basis of BDR and identified novel loci associated with this drug response in asthmatics. ..
  68. pmc Genome-wide association study of body mass index in 23 000 individuals with and without asthma
    E Melen
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Clin Exp Allergy 43:463-74. 2013
    ..Shared genetic factors between asthma and obesity have been proposed to partly explain epidemiological findings of co-morbidity between these conditions...
  69. pmc Genetic variants associated with angiotensin-converting enzyme inhibitor-associated angioedema
    Guillaume Pare
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Pharmacogenet Genomics 23:470-8. 2013
    ..The objective of this study was to identify genetic variants associated with angiotensin-converting enzyme (ACE) inhibitor-associated angioedema...
  70. doi Diagnostic significance of DOG-1 and PKC-θ expression and c-Kit/PDGFRA mutations in gastrointestinal stromal tumours
    Chao Wang
    Pathological Diagnosis Center, First Hospital of Jilin University, Changchun 130021, China
    Scand J Gastroenterol 48:1055-65. 2013
    ..To investigate discovered on gastrointestinal stromal tumor (GIST)-1 (DOG-1) and protein kinase C-θ (PKC-θ) expression in a series of GISTs and determine the sensitivity, specificity, and diagnostic value of these two antigens...
  71. doi PKC theta and p38 MAPK activate the EBV lytic cycle through autophagy induction
    Roberta Gonnella
    Department of Experimental Medicine, Sapienza University of Rome, Italy
    Biochim Biophys Acta 1853:1586-95. 2015
    ..In conclusion, this study reports, for the first time, that T/B activates a PKCθ-p38 MAPK axis in EBV infected B cells, that promotes the viral lytic cycle and cell survival and dephosphorylates AKT, balancing cell life and cell death. ..
  72. pmc Novel protein kinase C θ: coronin 1A complex in T lymphocytes
    Kerstin Siegmund
    Department for Pharmacology and Genetics, Division of Translational Cell Genetics, Medical University Innsbruck, Peter Mayr Str 1a, A 6020, Innsbruck, Austria
    Cell Commun Signal 13:22. 2015
    ..However, it is not yet entirely clear, how the function of PKCθ - upon T cell activation - is regulated on a molecular level...
  73. doi TCR-induced sumoylation of the kinase PKC-θ controls T cell synapse organization and T cell activation
    Xu Dong Wang
    State Key Laboratory of Biocontrol, Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat Sen University, Guangzhou, China
    Nat Immunol 16:1195-203. 2015
    ..Our findings demonstrate that sumoylation controls TCR-proximal signaling and that sumoylation of PKC-θ is essential for the formation of a mature immunological synapse and T cell activation. ..
  74. doi Candidate driver genes involved in genome maintenance and DNA repair in Sézary syndrome
    Wesley J Woollard
    St John s Institute of Dermatology, Division of Genetics and Molecular Medicine, Tower Wing, King s College London, London, United Kingdom
    Blood 127:3387-97. 2016
    ..This study is also the first to show BRCA2 defects in a significant proportion (14%) of SS tumors. Aberrations in PRKCQ were found to occur in 20% of tumors highlighting selection for activation of T-cell receptor/NF-κB signaling...
  75. doi Distinct genetic evolution patterns of relapsing diffuse large B-cell lymphoma revealed by genome-wide copy number aberration and targeted sequencing analysis
    D Juskevicius
    Institute of Pathology, University Hospital Basel, Basel, Switzerland
    Leukemia 30:2385-2395. 2016
    ..3-p12.1 containing the potential oncogenes PRKCQ, GATA3, MLLT10 and ABI1...
  76. ncbi A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx
    C L Ruegg
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    Cell Immunol 137:1-13. 1991
    ....
  77. pmc Trans-activation of HIV-1 LTR-directed gene expression by tat requires protein kinase C
    A Jakobovits
    Department of Molecular Biology, Genentech, Inc, South San Francisco, CA 94080
    EMBO J 9:1165-70. 1990
    ..Our results indicate that PKC regulates the process of HIV-1 transactivation, suggesting a key role for the mitogenic induction of trans-activation in the transition of HIV from latency to productive growth...
  78. ncbi Human immunodeficiency virus-1 recombinant gp120 induces changes in protein kinase C isozymes--a preliminary report
    S Gupta
    Division of Basic and Clinical Immunology, University of California, Irvine 92717
    Int J Immunopharmacol 16:197-204. 1994
    ..The most striking change was observed in PKC-zeta isozymes levels. This study for the first time demonstrates that HIV-1 gp120 affects calcium-independent PKC isozymes in U937 cells...
  79. pmc The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix
    S Swingler
    Infectious Disease Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Virol 71:4372-7. 1997
    ..Recombinant p21-activated kinase hPAK65, a recently proposed relative of the Nef-associated kinase, achieved a comparable result. Taken together, these data suggest that MA is a target of the Nef-associated serine kinase...
  80. ncbi Protein kinase C activation inhibits tyrosine phosphorylation of Cbl and its recruitment of Src homology 2 domain-containing proteins
    Y Liu
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 162:7095-101. 1999
    ....
  81. ncbi HIV-1 reverse transcriptase is phosphorylated in vitro and in a cellular system
    H Idriss
    Sealy Center for Molecular Science, The University of Texas Medical Branch Galveston, TX 77555 0851, USA
    Int J Biochem Cell Biol 31:1443-52. 1999
    ..Our results indicate that purified HIV-1 RT can be phosphorylated by several mammalian protein kinases in vitro and during expression in baculovirus infected insect cells...
  82. ncbi HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes
    I W Park
    Division of Experimental Medicine and Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, MA 02115, USA
    Blood 97:352-8. 2001
    ..These data indicate that the HIV-1 Tat protein may act as a protocytokine by causing the release of MCP-1 from the endothelial monolayer, and thereby facilitating monocyte transmigration into tissues via a PKC signaling pathway...
  83. ncbi Ki-1/57 interacts with RACK1 and is a substrate for the phosphorylation by phorbol 12-myristate 13-acetate-activated protein kinase C
    Flavia C Nery
    Centro de Biologia Molecular Estrutural, Laboratorio Nacional de Luz Sincrotron, Rua Giuseppe Máximo Scolfaro 10 000, C P 6192, 13084 971 Campinas, SP, Brasil
    J Biol Chem 279:11444-55. 2004
    ..These events associate Ki-1/57 with the RACK1/PKC pathway and may be important for the regulation of its cellular functions...
  84. doi c-FLIPL regulates PKC via AP-2 to inhibit Bax-mediated apoptosis induced by HIV-1 gp120 in Jurkat cells
    Xue Wang
    Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Building 29B, Rm 4NN16, 8800 Rockville Pike, Bethesda, MD, 20892, USA
    Mol Cell Biochem 330:23-9. 2009
    ..Collectively, these findings further corroborate the concept that gp120 plays an important role, via involvement of molecules such as c-FLIPL, in apoptotic cell death due to HIV-1 infection...
  85. pmc PKCθ synergizes with TLR-dependent TRAF6 signaling pathway to upregulate MUC5AC mucin via CARMA1
    Hirofumi Jono
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS ONE 7:e31049. 2012
    ..CARMA1 plays a crucial role in mediating this synergistic effect via TRAF6, thereby resulting in synergistic upregulation of MUC5AC mucin. Thus our study unveils a novel role for CARMA1 in mediating host mucosal innate immune response...
  86. pmc Protein kinase Cθ C2 domain is a phosphotyrosine binding module that plays a key role in its activation
    Robert V Stahelin
    Department of Chemistry, University of Illinois, Chicago, IL 60607, USA
    J Biol Chem 287:30518-28. 2012
    ..Collectively, these studies establish the C2 domain of PKCθ as a Tyr(P)-binding domain and suggest that the domain may play a major role in PKCθ activation via its Tyr(P) binding...
  87. pmc NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC-θ and reactive oxygen species
    Vincenzo Giambra
    Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    Nat Med 18:1693-8. 2012
    ....
  88. pmc The emerging role of protein kinase Cθ in cytoskeletal signaling
    Izabela Michalczyk
    Laboratory of Cytobiochemistry, Faculty of Biotechnology, University of Wroclaw, Wroclaw, Poland
    J Leukoc Biol 93:319-27. 2013
    ..Comprehensive understanding of cytoskeletal regulation and the cellular "modus operandi" of PKCθ holds promise for improving current therapeutic applications aimed at autoimmune diseases...
  89. doi PKC-θ exists in an oxidized inactive form in naive human T cells
    Marina Rode von Essen
    Department of International Health, Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    Eur J Immunol 43:1659-66. 2013
    ..Our observations underscore the existence of major differences in TCR signaling in naïve versus primed T cells. ..
  90. doi Mechanism of action of salvianolic acid B by module-based network analysis
    Zhenzhen Ren
    School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 100102, China
    Biomed Mater Eng 24:1333-40. 2014
    ..effect of Sal B was due to the immune response of T lymphocytes by regulating IL-2 family, CD3E, CD79A, MAP3K7 and PRKCQ. Therefore, the module-based network analysis will be an effective method for better understanding CMM.
  91. ncbi Human immunodeficiency virus induces phosphorylation of its cell surface receptor
    A P Fields
    Johns Hopkins Oncology Center, Baltimore, Maryland 21231
    Nature 333:278-80. 1988
    ..These results indicate a possible role for HIV-induced CD4 phosphorylation in viral entry and identify a potential target for antiviral therapy...
  92. ncbi Requirement for protein kinase C theta for cell cycle progression and formation of actin stress fibers and filopodia in vascular endothelial cells
    S Tang
    Vascular Biology Unit and Cardiovascular Division, Department of Medicine, Beth Israel Hospital and the Harvard Thorndike Laboratories, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 272:28704-11. 1997
    ..Thus, PKCtheta is required for multiple processes essential for angiogenesis and wound repair, including endothelial mitosis, maintenance of a normal actin cytoskeleton, and formation of an enclosed tube...
  93. ncbi Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells
    P Borgatti
    Division of Signal Transduction, Harvard Institute of Medicine, Beth Israel Hospital, Boston, Massachusettes 02115, USA
    Biochem Biophys Res Commun 242:332-7. 1998
    ..Taken together, these findings demonstrate that extracellular Tat shows a cytokine-like activity in PC12 cells, being able to trigger an intracellular signalling cascade which involves PKC-alpha, -epsilon, and -zeta...
  94. ncbi Phosphorylation of moesin by rho-associated kinase (Rho-kinase) plays a crucial role in the formation of microvilli-like structures
    N Oshiro
    Division of Signal Transduction, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma 630 0101, Japan
    J Biol Chem 273:34663-6. 1998
    ..These results indicate that Rho-kinase regulates moesin phosphorylation downstream of Rho in vivo and that the phosphorylation of moesin by Rho-kinase plays a crucial role in the formation of microvilli-like structures...
  95. ncbi Direct interaction in T-cells between thetaPKC and the tyrosine kinase p59fyn
    D Ron
    Telik, Inc, South San Francisco, California 94080, USA
    J Biol Chem 274:19003-10. 1999
    ....
  96. ncbi Effect of serine and tyrosine phosphorylation on retroviral proteinase substrates
    J Tozser
    Department of Biochemistry and Molecular Biology, University Medical School of Debrecen, Hungary
    Eur J Biochem 265:423-9. 1999
    ....
  97. ncbi Differential expression of protein kinase C isoform transcripts in human hematopoietic progenitors undergoing differentiation
    S Oshevski
    Hopital Paul Brousse, INSERM U 268, Villejuif Cedex, 94807, France
    Biochem Biophys Res Commun 263:603-9. 1999
    ....
  98. ncbi SPAK, a STE20/SPS1-related kinase that activates the p38 pathway
    A M Johnston
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Parkville 3050, Australia
    Oncogene 19:4290-7. 2000
    ..Oncogene (2000) 19, 4290 - 4297..
  99. ncbi Protein kinase C-theta mediates a selective T cell survival signal via phosphorylation of BAD
    M Villalba
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 166:5955-63. 2001
    ..We provide evidence that the distant Bcl-2 family member, BAD, is a PKCtheta substrate, is phosphorylated by TCR stimulation, and can mediate at least in part the anti-apoptotic effect of PKCtheta...
  100. ncbi Interaction of Bruton's tyrosine kinase and protein kinase Ctheta in platelets. Cross-talk between tyrosine and serine/threonine kinases
    David Crosby
    Department of Pharmacology, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom
    J Biol Chem 277:9958-65. 2002
    ..We propose a reciprocal feedback interaction between Btk and PKCtheta; in platelets, in which PKCtheta; positively modulates activity of Btk, which in turn feeds back negatively upon PKCtheta;...
  101. ncbi [HIV-1 Tat protein induces IL-10 production by human monocytes: implications of the PKC and calcium pathway]
    Y Bennasser
    Laboratoire d Immuno Virologie, Université Paul Sabatier 118, route de Narbonne, 31062 Toulouse
    J Soc Biol 195:319-26. 2001
    ..Using microspectrofluorimetry and confocal microscopy, we also show that Tat induces a calcium influx...

Research Grants4

  1. ANGARA KONETI RAO; Fiscal Year: 2016
    ..four genes (platelet factor 4 (PF4), myosin light chain (MYL9), 12-lipoxygenase (ALOX12) and protein kinase C- (PRKCQ) are indeed transcriptional targets of RUNX1, and they provide important insights into the platelet defects in the ..
  2. ANTIOXIDANTS AND FEMALE HORMONES IN THE ETIOLOGY OF RA
    Elizabeth Karlson; Fiscal Year: 2002
    ..RA will be confirmed by a screening questionnaire regarding rheumatic symptoms and review of medical records. The study will identify potentially modifiable risk factors for primary prevention of RA. ..
  3. Protective Mechanism of an Anti-Inflammatory Herbal Mix
    Ali Banan; Fiscal Year: 2006
    ..abstract_text> ..
  4. EGF, Oxidants & Intestinal Barrier Integrity
    Ali Banan; Fiscal Year: 2006
    ..abstract_text> ..