PRKAR2A

Summary

Gene Symbol: PRKAR2A
Description: protein kinase cAMP-dependent type II regulatory subunit alpha
Alias: PKR2, PRKAR2, cAMP-dependent protein kinase type II-alpha regulatory subunit, cAMP-dependent protein kinase regulatory subunit RII alpha, protein kinase A, RII-alpha subunit, protein kinase, cAMP-dependent, regulatory subunit type II alpha
Species: human

Top Publications

  1. ncbi Phosphorylation of the type-II regulatory subunit of cyclic-AMP-dependent protein kinase by glycogen synthase kinase 3 and glycogen synthase kinase 5
    B A Hemmings
    Eur J Biochem 127:473-81. 1982
  2. pmc Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold
    R S Westphal
    Howard Hughes Medical Institute, Vollum Institute, Portland, OR, USA
    EMBO J 19:4589-600. 2000
  3. ncbi MTG8 proto-oncoprotein interacts with the regulatory subunit of type II cyclic AMP-dependent protein kinase in lymphocytes
    T Fukuyama
    Saitama Cancer Center Research Institute, Saitama 362 0806, Japan
    Oncogene 20:6225-32. 2001
  4. ncbi Electrostatic properties of the structure of the docking and dimerization domain of protein kinase A IIalpha
    Dimitrios Morikis
    Department of Chemical and Environmental Engineering, University of California at Riverside, 92093 0359, USA
    Eur J Biochem 269:2040-51. 2002
  5. doi Triazine compounds as antagonists at Bv8-prokineticin receptors
    Gianfranco Balboni
    Department of Pharmaceutical Sciences, University of Ferrara, I 44100 Ferrara, Italy
    J Med Chem 51:7635-9. 2008
  6. pmc Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring
    Neal M Alto
    Howard Hughes Medical Institute, Vollum Institute, Oregon Health and Science University, Portland OR 97239, USA
    Proc Natl Acad Sci U S A 100:4445-50. 2003
  7. ncbi Molecular basis of AKAP specificity for PKA regulatory subunits
    Matthew G Gold
    Section of Structural Biology, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, United Kingdom
    Mol Cell 24:383-95. 2006
  8. ncbi Differential localization of two isoforms of the regulatory subunit RII alpha of cAMP-dependent protein kinase in human sperm: biochemical and cytochemical study
    C Pariset
    Departement de Biochimie, UFR Biomédicale des Saints Pères, Universite Rene Descartes, Paris, France
    Mol Reprod Dev 39:415-22. 1994
  9. ncbi Type II regulatory subunit (RII) of the cAMP-dependent protein kinase interaction with A-kinase anchor proteins requires isoleucines 3 and 5
    Z E Hausken
    Vollum Institute, Portland, Oregon 97201 3098
    J Biol Chem 269:24245-51. 1994
  10. ncbi Identification of a novel protein kinase A anchoring protein that binds both type I and type II regulatory subunits
    L J Huang
    Department of Chemistry and Biochemistry, School of Medicine, University of California, San Diego, La Jolla, California 92093 0654, USA
    J Biol Chem 272:8057-64. 1997

Research Grants

  1. Regulation of glucose homeostasis by prokineticin 2 signaling
    Qun Yong Zhou; Fiscal Year: 2012
  2. MECHANISM OF ACTION OF DIFFERENTIATION AGENTS
    Michael Brattain; Fiscal Year: 2008
  3. INTESTINAL ADENOSINE A2B RECEPTOR
    Shanthi Sitaraman; Fiscal Year: 2004
  4. Characterization of intestinal adenosine A2b receptor
    Shanthi Sitaraman; Fiscal Year: 2004
  5. Mutations in PKA gene transcripts of lupus T cells
    Dama Laxminarayana; Fiscal Year: 2007
  6. PROTEIN KINASE A ANCHORING IN SPERMATOZOAN FUNCTION
    Daniel W Carr; Fiscal Year: 2010

Scientific Experts

Detail Information

Publications146 found, 100 shown here

  1. ncbi Phosphorylation of the type-II regulatory subunit of cyclic-AMP-dependent protein kinase by glycogen synthase kinase 3 and glycogen synthase kinase 5
    B A Hemmings
    Eur J Biochem 127:473-81. 1982
  2. pmc Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold
    R S Westphal
    Howard Hughes Medical Institute, Vollum Institute, Portland, OR, USA
    EMBO J 19:4589-600. 2000
    ..Thus, we propose a previously unrecognized function for WAVE-1 as an actin-associated scaffolding protein that recruits PKA and Abl...
  3. ncbi MTG8 proto-oncoprotein interacts with the regulatory subunit of type II cyclic AMP-dependent protein kinase in lymphocytes
    T Fukuyama
    Saitama Cancer Center Research Institute, Saitama 362 0806, Japan
    Oncogene 20:6225-32. 2001
    ..Indirect immunofluorescence microscopy showed that MTG8 and RIIalpha were overlapped at the centrosome-Golgi area in lymphocytes. These findings suggest that MTG8 may function as an AKAP at the centrosome-Golgi area in lymphocytes...
  4. ncbi Electrostatic properties of the structure of the docking and dimerization domain of protein kinase A IIalpha
    Dimitrios Morikis
    Department of Chemical and Environmental Engineering, University of California at Riverside, 92093 0359, USA
    Eur J Biochem 269:2040-51. 2002
    ..We also discuss the structural requirements necessary for the formation of a stacked (rather than intertwined) dimer, which has consequences for the orientation of the functionally important and distinct faces...
  5. doi Triazine compounds as antagonists at Bv8-prokineticin receptors
    Gianfranco Balboni
    Department of Pharmaceutical Sciences, University of Ferrara, I 44100 Ferrara, Italy
    J Med Chem 51:7635-9. 2008
    ..New compounds were assessed for PKR1 and PKR2 affinity. Antagonist properties were evaluated as inhibition of 1 nM Bv8-induced intracellular Ca2+ mobilization.
  6. pmc Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring
    Neal M Alto
    Howard Hughes Medical Institute, Vollum Institute, Oregon Health and Science University, Portland OR 97239, USA
    Proc Natl Acad Sci U S A 100:4445-50. 2003
    ..Thus, computer-based and peptide array screening approaches have generated a reagent that binds PKA with higher affinity than previously described AKAPs...
  7. ncbi Molecular basis of AKAP specificity for PKA regulatory subunits
    Matthew G Gold
    Section of Structural Biology, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, United Kingdom
    Mol Cell 24:383-95. 2006
    ....
  8. ncbi Differential localization of two isoforms of the regulatory subunit RII alpha of cAMP-dependent protein kinase in human sperm: biochemical and cytochemical study
    C Pariset
    Departement de Biochimie, UFR Biomédicale des Saints Pères, Universite Rene Descartes, Paris, France
    Mol Reprod Dev 39:415-22. 1994
    ..These findings are in agreement with the concept of a concerted mechanism involving phosphorylation of both the axonemal microtubules and the fibrous structures for the regulation of mammalian sperm motion...
  9. ncbi Type II regulatory subunit (RII) of the cAMP-dependent protein kinase interaction with A-kinase anchor proteins requires isoleucines 3 and 5
    Z E Hausken
    Vollum Institute, Portland, Oregon 97201 3098
    J Biol Chem 269:24245-51. 1994
    ..Therefore, we propose that two isoleucine side chains on each RII protomer are principle sites of contact with the conserved amphipathic helix binding domain on AKAPs...
  10. ncbi Identification of a novel protein kinase A anchoring protein that binds both type I and type II regulatory subunits
    L J Huang
    Department of Chemistry and Biochemistry, School of Medicine, University of California, San Diego, La Jolla, California 92093 0654, USA
    J Biol Chem 272:8057-64. 1997
    ..These results raise a novel possibility that the type I regulatory subunit may be anchored via anchoring proteins...
  11. pmc D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain
    L J Huang
    Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, School of Medicine, University of California at San Diego, La Jolla, CA 92093 0654, USA
    Proc Natl Acad Sci U S A 94:11184-9. 1997
    ..The presence of this domain raises the intriguing possibility that D-AKAP2 may interact with a Galpha protein thus providing a link between the signaling machinery at the plasma membrane and the downstream kinase...
  12. ncbi Molecular cloning, chromosomal localization, and cell cycle-dependent subcellular distribution of the A-kinase anchoring protein, AKAP95
    T Eide
    Institute of Medical Biochemistry, University of Oslo, Blindern, Oslo, N 0317, Norway
    Exp Cell Res 238:305-16. 1998
    ..The results show a distinct redistribution of AKAP95 during mitosis, suggesting that the interaction between AKAP95 and RIIalpha may be cell cycle-dependent...
  13. ncbi PrKX is a novel catalytic subunit of the cAMP-dependent protein kinase regulated by the regulatory subunit type I
    B Zimmermann
    Institut fur Physiologische Chemie I, MA 2 40, Abteilung für Biochemie Supramolekularer Systeme, Medizinische Fakultät der Ruhr Universität Bochum, D 44801 Bochum, Germany
    J Biol Chem 274:5370-8. 1999
    ..We discuss how PrKX can modulate the cAMP-mediated signal transduction pathway by preferential binding to the RIalpha subunit and by phosphorylating the RIIalpha subunit in the absence of cAMP...
  14. ncbi The molecular basis for protein kinase A anchoring revealed by solution NMR
    M G Newlon
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla 92093 0359, USA
    Nat Struct Biol 6:222-7. 1999
    ..Interestingly, this same dimerization motif is present in other signaling molecules, the S100 family. Therefore, the X-type four-helix bundle may represent a conserved fold for protein-protein interactions in signal transduction...
  15. pmc A transforming growth factor beta-induced Smad3/Smad4 complex directly activates protein kinase A
    Lizhi Zhang
    Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Mol Cell Biol 24:2169-80. 2004
    ..Taken together, these data indicate an important and previously unrecognized interaction between the TGFbeta and PKA signaling pathways...
  16. doi Control of PKA stability and signalling by the RING ligase praja2
    Luca Lignitto
    Dipartimento di Biologia e Patologia Cellulare e Molecolare L Califano, Universita Federico II, 80131 Naples, Italy
    Nat Cell Biol 13:412-22. 2011
    ..Praja2 is required for efficient nuclear cAMP signalling and for PKA-mediated long-term memory. Thus, praja2 regulates the total concentration of R subunits, tuning the strength and duration of PKA signal output in response to cAMP...
  17. ncbi Cloning and characterization of AKAP 95, a nuclear protein that associates with the regulatory subunit of type II cAMP-dependent protein kinase
    V M Coghlan
    Volum Institute of Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201
    J Biol Chem 269:7658-65. 1994
    ..The results suggest that AKAP 95 could play a role in targeting type II cAMP-dependent protein kinase for cAMP-responsive nuclear events...
  18. ncbi Molecular pathogenesis of Kallmann's syndrome
    Steven Mark Cadman
    Centre for Neuroendocrinology, Royal Free and University College Medical School, University College London, London, UK
    Horm Res 67:231-42. 2007
    ..we review the known normosmic causes of HH, and discuss novel developmental and molecular mechanisms underlying KS; finally, we introduce three novel genes (NELF, PKR2, and CHD7) that may be associated with some phenotypic features of KS.
  19. doi Pancreatic islet and stellate cells are the main sources of endocrine gland-derived vascular endothelial growth factor/prokineticin-1 in pancreatic cancer
    Xiaohua Jiang
    Department of Surgery, Technische Universitat Munchen, Munich, Germany
    Pancreatology 9:165-72. 2009
    ..This study investigates the expression and localization of EG-VEGF and its receptors in pancreatic tissues and pancreatic stellate cells (PSCs)...
  20. pmc CHD3 proteins and polycomb group proteins antagonistically determine cell identity in Arabidopsis
    Ernst Aichinger
    Department of Biology and Zurich Basel Plant Science Center, Swiss Federal Institute of Technology, ETH Centre, Zurich, Switzerland
    PLoS Genet 5:e1000605. 2009
    ..Here, we report that the chromodomain/helicase/DNA-binding domain CHD3 proteins PICKLE (PKL) and PICKLE RELATED2 (PKR2) have trxG-like functions in plants and are required for the expression of many genes that are repressed by PcG ..
  21. doi Characterization and regulation of bv8 in human blood cells
    CUILING ZHONG
    Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Clin Cancer Res 15:2675-84. 2009
    ..Bv8, also known as prokineticin 2, has been recently shown to be a mediator of myeloid cell-dependent tumor angiogenesis in mouse models. We wished to determine whether these findings might be potentially relevant to human disease...
  22. ncbi Bv8/Prokineticin proteins and their receptors
    Lucia Negri
    Department of Human Physiology and Pharmacology V Erspamer, University La Sapienza, P le A Moro 5, 00185 Rome, Italy
    Life Sci 81:1103-16. 2007
    ..in frog, fish, reptiles and mammals that signal through two highly homologous G-protein coupled receptors, PKR1 and PKR2. Bv8/PK proteins possess a unique structural motif comprising five disulfide bonds and a completely conserved N-..
  23. ncbi Type II regulatory subunit dimerization determines the subcellular localization of the cAMP-dependent protein kinase
    J D Scott
    Vollum Institute for Advanced Biomedical Research, Portland, Oregon 97201
    J Biol Chem 265:21561-6. 1990
    ..Therefore, anchored PKA holoenzyme topology may position the catalytic subunit and MAP2 as to allow its preferential phosphorylation upon kinase activation...
  24. ncbi Human testis cDNA for the regulatory subunit RII alpha of cAMP-dependent protein kinase encodes an alternate amino-terminal region
    O Oyen
    Institute of Pathology, Rikshospitalet, Oslo, Norway
    FEBS Lett 246:57-64. 1989
    ....
  25. ncbi A role for receptor kinases in the regulation of class II G protein-coupled receptors. Phosphorylation and desensitization of the secretin receptor
    M A Shetzline
    Howard Hughes Medical Institute, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 273:6756-62. 1998
    ..These results demonstrate that the GRK-arrestin system regulates Class II G protein-coupled receptors...
  26. ncbi Identification of tethering domains for protein kinase A type Ialpha regulatory subunits on sperm fibrous sheath protein FSC1
    K Miki
    Gamete Biology Group, Laboratory of Reproductive and Developmental Toxicology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 273:34384-90. 1998
    ..This was supported by the finding that site-directed mutagenesis to disrupt the amphipathic helix eliminated RIalpha binding. This is apparently the first report of an RIalpha-specific protein kinase A anchoring protein tethering domain...
  27. ncbi AKAP-Lbc nucleates a protein kinase D activation scaffold
    Graeme K Carnegie
    Howard Hughes Medical Institute, Vollum Institute, Oregon Health and Sciences University, Portland, OR 97239, USA
    Mol Cell 15:889-99. 2004
    ..This configuration illustrates the utility of kinase anchoring as a mechanism to constrain the action of broad-spectrum enzymes...
  28. doi Phosphorylation of APOBEC3G by protein kinase A regulates its interaction with HIV-1 Vif
    Kotaro Shirakawa
    Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawaracho, Sakyo ku, Kyoto 606 8507, Japan
    Nat Struct Mol Biol 15:1184-91. 2008
    ..These data imply that PKA-mediated phosphorylation of A3G can regulate the interaction between A3G and Vif...
  29. doi Bv8/Prokineticins and their Receptors A New Pronociceptive System
    Lucia Negri
    Department of Physiology and Pharmacology, University Sapienza of Roma, P le Aldo Moro 5, 00185 Rome, Italy
    Int Rev Neurobiol 85:145-57. 2009
    ..PK1 and PK2, and their G-protein coupled receptors prokineticin receptor 1 (PKR1) and prokineticin receptor 2 (PKR2) have been identified and linked to several biological effects as gut motility, neurogenesis, angiogenesis, ..
  30. pmc Protein kinase A phosphorylation activates Vpr-induced cell cycle arrest during human immunodeficiency virus type 1 infection
    R Anthony Barnitz
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Dr, Bethesda, MD 20892 1892, USA
    J Virol 84:6410-24. 2010
    ..Inhibition of PKA activity during HIV-1 infection abrogates Vpr cell cycle arrest. These findings provide new insight into the signaling event that activates Vpr cell cycle arrest, ultimately leading to the death of infected T cells...
  31. pmc Alpha-synuclein sequesters Dnmt1 from the nucleus: a novel mechanism for epigenetic alterations in Lewy body diseases
    Paula Desplats
    Department of Neurosciences, School of Medicine, University of California at San Diego, La Jolla, California 92093, USA
    J Biol Chem 286:9031-7. 2011
    ..in global DNA hypomethylation in human and mouse brains, involving CpG islands upstream of SNCA, SEPW1, and PRKAR2A genes...
  32. pmc Disease-causing mutation in PKR2 receptor reveals a critical role of positive charges in the second intracellular loop for G-protein coupling and receptor trafficking
    Zhen Peng
    State Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan 410078, China
    J Biol Chem 286:16615-22. 2011
    ..involved in many physiological processes by binding to two closely related G-protein-coupled receptors, PKR1 and PKR2. Recently, mutations in prokineticin 2 (PK2) and PKR2 are found to be associated with Kallmann syndrome and/or ..
  33. pmc Differential PKA activation and AKAP association determines cell fate in cancer cells
    Erik D Hedrick
    Eppley Cancer Center, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, NE 68198 5950, USA
    J Mol Signal 8:10. 2013
    ..In this study, we evaluated the effect of IGF1R inhibition or activation on PKA activation and its downstream cell survival signaling mechanisms...
  34. doi Can prokineticin prevent obesity and insulin resistance?
    Jean Jacques Von Hunolstein
    University of Strasbourg, CNRS, Biotechnology and Cell Signaling Laboratory UMR 7242, Illkirch, France
    Curr Opin Endocrinol Diabetes Obes 22:367-73. 2015
    ..They act on the G protein-coupled receptors PKR1 and PKR2. This review aims to provide an overview of current knowledge of the role of prokineticins and their receptors in ..
  35. pmc Hematopoietic neoplasms in Prkar2a-deficient mice
    Emmanouil Saloustros
    Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics PDEGEN and Pediatric Endocrinology Inter Institute Training Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development NICHD, National Institutes of Health NIH, Bethesda, MD, 20892, USA
    J Exp Clin Cancer Res 34:143. 2015
    ..Mice with inactivation of the Prkar2a and Prkar2b genes (coding for RIIα and RIIβ, respectively) are also viable but have not been studied for their ..
  36. doi Snapin interacts with G-protein coupled receptor PKR2
    Jian Song
    The State Key Laboratory of Medical Genetics and School of Life Sciences, Central South University, Changsha, Hunan, China Department of Otolaryngology, Xiangya Hospital, Central South University, Changsha, Hunan 410078, China
    Biochem Biophys Res Commun 469:501-6. 2016
    Mutations in Prokineticin receptor 2 (PKR2), a G-protein-coupled receptor, have been identified in patients with Kallmann syndrome and/or idiopathic hypogonadotropic hypogonadism, characterized by delayed puberty and infertility...
  37. pmc Expression of prokineticin 2 and its receptor in the macaque monkey brain
    Katherine J Burton
    a Department of Pharmacology, University of California, Irvine, Irvine, CA, USA
    Chronobiol Int 33:191-9. 2016
    ..In the current study, the PK2 and its receptor, PKR2, was cloned from a species of diurnal macaque monkey...
  38. pmc The A-Kinase Anchoring Protein (AKAP) Glycogen Synthase Kinase 3β Interaction Protein (GSKIP) Regulates β-Catenin through Its Interactions with Both Protein Kinase A (PKA) and GSK3β
    Alessandro Dema
    From the Max Delbrück Center for Molecular Medicine in the Helmholtz Association MDC, Robert Rossle Strasse 10, 13125 Berlin, Germany and
    J Biol Chem 291:19618-30. 2016
    ....
  39. ncbi Integrated analysis identified an intestinal-like and a diffuse-like gene sets that predict gastric cancer outcome
    Cheng Zhang
    Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Department of Biochemistry and Molecular Biology, Peking University Cancer Hospital and Institute, 52 Fucheng Road, Beijing, 100142, China
    Tumour Biol . 2016
    ..Among genes overexpressed in intestinal subtype, ATPIF1, PRDX2, PRKAR2A, and SMC1A were correlated with positive prognosis...
  40. ncbi Diminished levels of protein kinase A RI alpha and RI beta transcripts and proteins in systemic lupus erythematosus T lymphocytes
    D Laxminarayana
    Section on Rheumatology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Immunol 162:5639-48. 1999
    ..In conclusion, reduced expression of RIalpha and RIbeta transcripts is associated with a decrement in RIalpha and RIbeta proteins and may contribute to deficient type I protein kinase A isozyme activity in SLE T cells...
  41. ncbi PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts
    S O Marx
    Center for Molecular Cardiology, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Cell 101:365-76. 2000
    ..6, PKA, the protein phosphatases PP1 and PP2A, and an anchoring protein, mAKAP. In failing human hearts, RyR2 is PKA hyperphosphorylated, resulting in defective channel function due to increased sensitivity to Ca2+-induced activation...
  42. ncbi Neurobeachin: A protein kinase A-anchoring, beige/Chediak-higashi protein homolog implicated in neuronal membrane traffic
    X Wang
    Institut für Physiologische Chemie and Institut für Anatomie, Ruhr Universitat Bochum, D 44780 Bochum, Germany
    J Neurosci 20:8551-65. 2000
    ....
  43. ncbi Gene expression patterns in acute myeloid leukemia correlate with centrosome aberrations and numerical chromosome changes
    Kai Neben
    Division of Molecular Genetics B060, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Oncogene 23:2379-84. 2004
    ..CDK6, p18INK4c, p21Cip1, PAK1) and centrosome-associated proteins (pericentrin, alpha2-tubulin, NUMA1, TUBGCP2, PRKAR2A)...
  44. pmc Expression of prokineticins and their receptors in the adult mouse brain
    Michelle Y Cheng
    Department of Pharmacology, University of California, Irvine, 92697 4625, USA
    J Comp Neurol 498:796-809. 2006
    ..Here we report a comprehensive mRNA distribution for both prokineticins (PK1 and PK2) and their receptors (PKR1 and PKR2) in the adult mouse brain with the use of in situ hybridization...
  45. ncbi Diversity in fibroblast growth factor receptor 1 regulation: learning from the investigation of Kallmann syndrome
    S H Kim
    Centre for Neuroendocrinology, Royal Free and University College Medical School, University College London, London, UK
    J Neuroendocrinol 20:141-63. 2008
    ..Recently, mutations in the genes encoding prokineticin 2 (PK2) and prokineticin receptor 2 (PKR2) were reported in a cohort of KS patients, further reinforcing the view of KS as a multigenic trait involving ..
  46. pmc Modulators of pain: Bv8 and prokineticins
    Lucia Negri
    Department of Human Physiology and Pharmacology, University of Rome La Sapienza Roma, Italia
    Curr Neuropharmacol 4:207-15. 2006
    ..Mammalian homologues of Bv8, the prokineticins PK1 and PK2, and their G-protein coupled receptors PKR1 and PKR2 have been identified and linked to several biological effects...
  47. ncbi The HIV-1 matrix protein p17 activates the transcription factors c-Myc and CREB in human B cells
    Song Li
    Institute of Human Virology, University of Maryland, School of Medicine, Baltimore 21201, USA
    New Microbiol 33:13-24. 2010
    ..As both CREB and c-Myc are involved in the regulation of cell proliferation, differentiation, and survival, our findings might suggest a potential mechanism of B cell lymphomagenesis during HIV-1 infection...
  48. doi Analyses of the involvement of PKA regulation mechanism in meiotic incompetence of porcine growing oocytes
    Takanori Nishimura
    Laboratory of Applied Genetics, Graduate School of Agriculture and Life Science, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Biol Reprod 87:53. 2012
    ..PKA-C, was insufficient to suppress PKA activity in GOs because of the overexpression of two PKA-Rs, PRKAR1A and PRKAR2A. We found that neither of them affected PKA activity and induced meiotic resumption in GO although PRKAR2A could ..
  49. pmc Binding of regulatory subunits of cyclic AMP-dependent protein kinase to cyclic CMP agarose
    Andreas Hammerschmidt
    Institute of Pharmacology, Hannover Medical School, Hannover, Germany
    PLoS ONE 7:e39848. 2012
    ..In agreement with our functional data, RIα and RIIα were identified as cCMP-binding proteins. These data corroborate the notion that cAMP-dependent protein kinase may serve as a cCMP target...
  50. doi Prokineticin receptor variants (PKR1-I379V and PKR2-V331M) are protective genotypes in human early pregnancy
    Mei Tsz Su
    Division of Genetics, Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, National Cheng Kung University, 138 Sheng Li Road, Tainan 704, Taiwan
    Reproduction 146:63-73. 2013
    ..gland-derived vascular endothelial growth factor (EG-VEGF) and its receptor genes (PROKR1 (PKR1) and PROKR2 (PKR2)) play an important role in human early pregnancy...
  51. pmc Prokineticin receptor 1 as a novel suppressor of preadipocyte proliferation and differentiation to control obesity
    Cécilia Szatkowski
    Institute of Research and Biotechnology of Strasbourg, Centre National de la Recherche Scientifique, UMR7242, University of Strasbourg, Medalis Labex, Drug Discovery Center, Illkirch, France
    PLoS ONE 8:e81175. 2013
    ..is an angiogenic and anorexigenic hormone that activate two G protein-coupled receptors (GPCRs): PKR1 and PKR2. Prokineticin-2 regulates food intake and energy metabolism via central mechanisms (PKR2)...
  52. doi Cytoplasmic anchoring of cAMP-dependent protein kinase (PKA) by A-kinase anchor proteins (AKAPs) is required for meiotic arrest of porcine full-grown and growing oocytes
    Takanori Nishimura
    Laboratory of Applied Genetics, Graduate School of Agriculture and Life Sciences University of Tokyo, Bunkyo ku, Tokyo, Japan
    Biol Reprod 90:58. 2014
    ..PRKAR1A, an isoform of mammalian PKA-R, promoted meiotic resumption of porcine GOs, whereas these inhibitions of PRKAR2A, another PKA-R isoform, had no effect...
  53. doi PKA regulatory subunit expression in tooth development
    Sílvia Ferreira de Sousa
    Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil Electronic address
    Gene Expr Patterns 15:46-51. 2014
    ..aim of the present study was to assess the expression of alpha isoforms of PKA regulatory subunit (Prkar1a and Prkar2a) in mouse and human odontogenesis by in situ hybridization...
  54. doi Prokineticin receptor identified by phage display is an entry receptor for Trypanosoma cruzi into mammalian cells
    K G Khusal
    Departamento de Bioquimica, Universidade de Sao Paulo, Instituto de Quimica, Av Prof Lineu Prestes 748 Cidade Universitária, 05508 900, Sao Paulo, Brazil
    Parasitol Res 114:155-65. 2015
    ..Herein, the sequence GGIALAG present in prokineticin-2 receptor (PKR2), selected by phage display technology, is described as a new T...
  55. doi A closer look at evolution: Variants (SNPs) of genes involved in skin pigmentation, including EXOC2, TYR, TYRP1, and DCT, are associated with 25(OH)D serum concentration
    Roman Saternus
    Department of Dermatology R S, T V, J R, The Saarland University Hospital, 66424 Homburg, Germany Department of Epidemiology and Biostatistics S P, EMGO Institute for Health and Care Research, Vrije Universiteit Medisch Centrum, 1081 BT Amsterdam, The Netherlands Department of Internal Medicine S P, Division of Endocrinology and Metabolism, Medical University of Graz, 8036 Graz, Austria Institute of Medical Biometry, Epidemiology, and Medical Informatics S G, The Saarland University Hospital, Homburg, Germany and Mannheim Institute of Public Health M K, W M, Heidelberg University, 68167 Mannheim, Germany
    Endocrinology 156:39-47. 2015
    ..kinase type I-alpha regulatory subunit [PRKAR1A], cAMP-dependent protein kinase type II-alpha regulatory subunit [PRKAR2A], cAMP-dependent protein kinase type II-beta regulatory subunit [PRKAR2B], tubulin beta-3 chain/melanocortin ..
  56. pmc Protein kinase A type II-α regulatory subunit regulates the response of prostate cancer cells to taxane treatment
    Evan R Zynda
    a Department of Cell Stress Biology Roswell Park Cancer Institute Buffalo, NY USA
    Cell Cycle 13:3292-301. 2014
    ..High-throughput mapping of the integration sites pointed to the PRKAR2A gene, which codes for a type II-α regulatory subunit of protein kinase A, as a candidate modulator of drug ..
  57. pmc Prokineticin 2 upregulation in the peripheral nervous system has a major role in triggering and maintaining neuropathic pain in the chronic constriction injury model
    Roberta Lattanzi
    Department of Physiology and Pharmacology Vittorio Erspamer, Sapienza University of Rome, 00185 Rome, Italy
    Biomed Res Int 2015:301292. 2015
    The new chemokine Prokineticin 2 (PROK2) and its receptors (PKR1 and PKR2) have a role in inflammatory pain and immunomodulation...
  58. pmc Neurochondrin is an atypical RIIα-specific A-kinase anchoring protein
    Jennifer S Hermann
    Department of Biochemistry, University of Kassel, Heinrich Plett Strasse 40, 34132 Kassel, Germany
    Biochim Biophys Acta 1854:1667-75. 2015
    ..In addition, we demonstrate that neurochondrin has strong isoform selectivity towards the RIIα subunit of PKA with nanomolar affinity. This article is part of a Special Issue entitled: Inhibitors of Protein Kinases. ..
  59. pmc 'Conceptualizing' the Endometrium: Identification of Conceptus-Derived Proteins During Early Pregnancy in Cattle
    Niamh Forde
    School of Agriculture and Food Science, University College Dublin, Ireland
    Biol Reprod 92:156. 2015
    ..in the conceptus compared to the endometrium (ARPC5L, CAPG, CKMT1, CSTB, HSPA8, HSPE1, LGALS3, MSN, NUTF2, P4HB, PRKAR2A, TKT) as determined by RNA sequencing...
  60. pmc Haploinsufficiency for either one of the type-II regulatory subunits of protein kinase A improves the bone phenotype of Prkar1a+/- mice
    Sisi Liu
    Section on Endocrinology and Genetics SEGEN, Program on Developmental Endocrinology and Genetics PDEGEN, Eunice Kennedy Shriver National Institute of Child Health and Human Development NICHD
    Hum Mol Genet 24:6080-92. 2015
    ..activity due to an unregulated PKA catalytic subunit and increased PKA type II (PKA-II) activity mediated by the PRKAR2A and PRKAR2B subunits...
  61. pmc Expression of prokineticin-receptor2(PK-R2) is a new prognostic factor in human colorectal cancer
    Takanori Goi
    First Department of Surgery, University of Fukui, Fukui, Japan
    Oncotarget 6:31758-66. 2015
    ..In the multivariate analysis for prognosis, PK-R2 expression was found to be an independent factor(ratio2.621).PK-R2 expression could be one of the new prognostic factors in human colorectal cancer. ..
  62. ncbi Anosmin 1 Interacts with the Prokineticin Receptor 2 In Vitro Indicating a Molecular Link Between Both Proteins in the Pathogenesis of Kallmann Syndrome
    Verónica Murcia-Belmonte
    Hospital Nacional de Paraplejicos, Finca de La Peraleda s n, 45071, Toledo, Spain
    Protein Pept Lett 23:650-5. 2016
    Sexual maturation and olfactory bulb defects found in prokineticin 2 (Pk2) and prokineticin receptor 2 (Pkr2) mutant mice resembling the phenotypic characteristics of Kallmann syndrome (KS), gave rise to the question of whether these ..
  63. ncbi Aging has the opposite effect on cAMP and cGMP circadian variations in rat Leydig cells
    Aleksandar Z Baburski
    LaRES, Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, Dositeja Obradovica Sq 2, Novi Sad, 21000, Serbia
    J Comp Physiol B . 2016
    ..circadian pattern of Pde7b and Pde8a); and circadian expression of protein kinase A subunits (Prkac/PRKAC and Prkar2a)...
  64. ncbi cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes
    S S Taylor
    Department of Chemistry, University of California, San Diego, La Jolla 92093
    Annu Rev Biochem 59:971-1005. 1990
    ....
  65. ncbi Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus
    Michelle Y Cheng
    Department of Pharmacology, University of California, Irvine, California 92697, USA
    Nature 417:405-10. 2002
    ..Receptor for PK2 (PKR2) is abundantly expressed in major target nuclei of the SCN output pathway...
  66. ncbi Phosphorylation of HIV Nef by cAMP-dependent protein kinase
    Pei Lin Li
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Virology 331:367-74. 2005
    ..As this mutation played a major role in abrogating the Nef effect on HIV replication in unstimulated primary cells, we postulate that Nef phosphorylation by PKA is an important step in the viral life cycle in resting cells...
  67. pmc Impaired pain sensation in mice lacking prokineticin 2
    Wang Ping Hu
    Department of Pharmacology, University of California, Irvine, CA 92697, USA
    Mol Pain 2:35. 2006
    ..Two closely related G-protein coupled receptors, PKR1 and PKR2, mediate the signaling of PKs...
  68. ncbi Placental expression of EG-VEGF and its receptors PKR1 (prokineticin receptor-1) and PKR2 throughout mouse gestation
    P Hoffmann
    INSERM, Unité 878, Grenoble, France
    Placenta 28:1049-58. 2007
    ..We investigated the pattern of expression of EG-VEGF and its receptors, PKR1 and PKR2 at the mRNA and protein levels...
  69. doi Identification of a clinically homogenous subgroup of benign cortisol-secreting adrenocortical tumors characterized by alterations of the protein kinase A (PKA) subunits and high PKA activity
    C Vincent-Dejean
    INSERM U567, CNRS UMR8104, Endocrinology, Metabolism and Cancer Department, Institut Cochin, 75014 Paris, France
    Eur J Endocrinol 158:829-39. 2008
    ..PKA is a heterotetramer with two regulatory subunits (four genes: PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B) and two catalytic subunits...
  70. doi Proteomic analysis of GTP cyclohydrolase 1 multiprotein complexes in cultured normal adult human astrocytes under both basal and cytokine-activated conditions
    Anna Chiarini
    Department of Biomedical and Surgical Sciences, Histology and Embryology Unit, University of Verona Medical School, Verona, Italy
    Proteomics 9:1850-60. 2009
    ..These findings provide a first enticing glimpse into the intricate mechanisms regulating GCH1 activation by proinflammatory cytokines in NAHA, and may have therapeutic implications...
  71. doi Prokineticin receptors in cardiovascular function: foe or friend?
    Canan G Nebigil
    CNRS, Universite de Strasbourg, FRE 3211 Ecole Supérieure de Biotechnologie de Strasbourg, F 67412 Illkirch, France
    Trends Cardiovasc Med 19:55-60. 2009
    ..The knowledge gained from these studies leads to a model in which PKR1 and PKR2 signaling exert opposing actions in heart physiology and pathophysiology and facilitate the discovery of specific ..
  72. doi Role of EG-VEGF in human placentation: Physiological and pathological implications
    Pascale Hoffmann
    Institut National de la Sante et de la Recherche Medicale, Grenoble, France
    J Cell Mol Med 13:2224-35. 2009
    ..trimester extravillous trophoblast cell line, we showed differential expression of EG-VEGF receptors, PKR1 and PKR2, in the placenta and demonstrated that EG-VEGF inhibits EVT migration, invasion and tube-like organisation...
  73. pmc The chemokine Bv8/prokineticin 2 is up-regulated in inflammatory granulocytes and modulates inflammatory pain
    Elisa Giannini
    Department of Physiology and Pharmacology Vittorio Erspamer, Sapienza University of Rome, I 00185 Rome, Italy
    Proc Natl Acad Sci U S A 106:14646-51. 2009
    ..Mice lacking PKR1 or PKR2 developed significantly less inflammation-induced hyperalgesia in comparison with WT mice, confirming the ..
  74. doi Viral genetic determinants of nonprogressive HIV type 1 subtype C infection in antiretroviral drug-naive children
    D B Tzitzivacos
    HIV Pathogenesis Research Laboratory, Department of Molecular Medicine and Haematology, University of the Witwatersrand Medical School, Parktown, Johannesburg 2193, South Africa
    AIDS Res Hum Retroviruses 25:1141-8. 2009
    ..For example, LT46 Nef is unable to bind AP-1 and AP-2 and therefore is inactive on CD4 endocytosis. The biological relevance of these findings requires further investigation...
  75. doi Divergent roles of prokineticin receptors in the endothelial cells: angiogenesis and fenestration
    Célia Guilini
    Institut de Recherche de l Ecole de Biotechnologie de Strasbourg, Centre National de la Recherche Scientifique, Universite de Strasbourg, Illkirch, France
    Am J Physiol Heart Circ Physiol 298:H844-52. 2010
    Prokineticins are secreted peptides that activate two G protein-coupled receptors: PKR1 and PKR2. Prokineticins induce angiogenesis and fenestration, but the cognate receptors involved in these functions are unknown...
  76. doi Evidence that prokineticin receptor 2 exists as a dimer in vivo
    Sara Marsango
    Dipartimento di Scienze Biochimiche A Rossi Fanelli, Sapienza Universita di Roma, Piazzale Aldo Moro 5, 00185, Rome, Italy
    Cell Mol Life Sci 68:2919-29. 2011
    ..Prokineticins bind two closed related G-protein coupled receptors (GPCRs), PKR1 and PKR2. In general, these receptors act as molecular switches to relay activation to heterotrimeric G-proteins and a ..
  77. ncbi Bv8-prokineticins and their receptors: modulators of pain
    Lucia Negri
    Department of Physiology and Pharmacology Vittorio Erspamer, Sapienza University of Rome, P le A Moro 5, 00185 Rome, Italy
    Curr Pharm Biotechnol 12:1720-7. 2011
    ..Mammalian homologues of Bv8, the prokineticins PK1 and PK2, and their G-protein coupled receptors PKR1 and PKR2 have been identified and linked to several biological effects as gut motility, circadian rhythms, neurogenesis, ..
  78. doi Increased prokineticin 2 expression in gut inflammation: role in visceral pain and intestinal ion transport
    Robert P Watson
    Novartis Institutes for BioMedical Research, Novartis Horsham Research Centre, Horsham, West Sussex, UK
    Neurogastroenterol Motil 24:65-75, e12. 2012
    ..Given the established role of prokineticin signaling on gastrointestinal function, we have explored Prok2 gene expression in inflammatory conditions of the gastrointestinal tract and assessed the possible consequences on gut physiology...
  79. doi Bv8/PK2 and prokineticin receptors: a druggable pronociceptive system
    Lucia Negri
    Department of Physiology and Pharmacology Vittorio Erspamer, Sapienza, University of Rome, P le A Moro 5, 00185 Rome, Italy
    Curr Opin Pharmacol 12:62-6. 2012
    ..a new family of chemokines, which activate two G-protein linked receptors (prokineticin receptor 1 and 2, PKR1 and PKR2) expressed in regions of the nervous system associated with pain and in cells participating to immuno-inflammatory ..
  80. pmc Protein kinase A modulates transforming growth factor-β signaling through a direct interaction with Smad4 protein
    Huibin Yang
    Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 288:8737-49. 2013
    ..Moreover, this Smad4-PKA interaction was required for TGFβ-induced epithelial mesenchymal transition, invasion of pancreatic tumor cells, and regulation of tumor growth in vivo...
  81. ncbi Identification, purification, and characterization of subunits of cAMP-dependent protein kinase in human testis. Reverse mobilities of human RII alpha and RII beta on sodium dodecyl sulfate-polyacrylamide gel electrophoresis compared with rat and bovine R
    B S Skalhegg
    Institute of Pathology, Rikshospitalet, Oslo, Norway
    J Biol Chem 267:5374-9. 1992
    ..This study supports the conclusion that the mobilities of human RII subunits (RII alpha, RII beta) on SDS-PAGE are reversed in contrast with those of other species such as rat and bovine.(ABSTRACT TRUNCATED AT 400 WORDS)..
  82. ncbi Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain
    D W Carr
    Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201
    J Biol Chem 267:13376-82. 1992
    ..The nanomolar affinity constant and the different patterns of RII-anchoring proteins in each tissue suggest that the type II alpha PKA holoenzyme may be specifically targeted to different locations in each type of cell...
  83. ncbi Localization and characterization of the binding site for the regulatory subunit of type II cAMP-dependent protein kinase on MAP2
    H M Rubino
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461
    Neuron 3:631-8. 1989
    ..The amino acid sequence of this fragment (DRETAEEVSARIVQVVTAEAVAVLKGEQEKE) is totally conserved between human and mouse MAP2, suggesting an important role for the RII binding site of MAP2 in neuronal function...
  84. pmc Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes
    B Hofmann
    Center for Interdisciplinary Research in Immunology and Disease, Johnson Comprehensive Cancer Center, University of California, Los Angeles 90024 1747
    Proc Natl Acad Sci U S A 90:6676-80. 1993
    ..These studies show that the HIV-induced augmentation of cAMP/PKA activity may be a key part of the mechanism responsible for all or part of the HIV-induced anergy of T lymphocytes...
  85. ncbi Type II regulatory subunits of cAMP-dependent protein kinase and their binding proteins in the nervous system of Aplysia californica
    S Cheley
    Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts 01545
    J Biol Chem 269:2911-20. 1994
    ....
  86. ncbi HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro
    B Hofmann
    AIDS 8:1016-7. 1994
  87. ncbi Differential expression of cyclic AMP-dependent protein kinase isozymes in normal human melanocytes and malignant melanomas
    S J Beebe
    Department of Pediatrics, Eastern Virginia Medical School, Norfolk 23510
    Cell Growth Differ 4:1005-12. 1993
    ..Differences were noted for the ratios of RI/RII and RI holoenzyme/free RI subunit among different melanomas...
  88. ncbi Cloning and characterization of a novel A-kinase anchoring protein. AKAP 220, association with testicular peroxisomes
    L B Lester
    Vollum Institute, Portland, Oregon 97201, USA
    J Biol Chem 271:9460-5. 1996
    ..Collectively, these results suggest that AKAP 220 may play a role in targeting type II PKA for cAMP-responsive peroxisomal events...
  89. ncbi Molecular cloning, upstream sequence and promoter studies of the human gene for the regulatory subunit RII alpha of cAMP-dependent protein kinase
    K B Foss
    Institute of Medical Biochemistry, University of Oslo, Norway
    Biochim Biophys Acta 1350:98-108. 1997
    ..We show that the low homology region of the human RII alpha cDNA resides entirely within exon 1, and does not originate from a tissue-specific alternate splicing of this distinct region...
  90. pmc Ezrin is a cyclic AMP-dependent protein kinase anchoring protein
    D T Dransfield
    Institute of Molecular Medicine and Genetics, Medical College of Georgia and the Augusta Veterans Affairs Medical Center, 30912, USA
    EMBO J 16:35-43. 1997
    ..These results demonstrate that ezrin is a major AKAP in gastric parietal cells and may function to tether type II A-kinase to a region near the secretory canaliculus...
  91. pmc The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix
    S Swingler
    Infectious Disease Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Virol 71:4372-7. 1997
    ..Recombinant p21-activated kinase hPAK65, a recently proposed relative of the Nef-associated kinase, achieved a comparable result. Taken together, these data suggest that MA is a target of the Nef-associated serine kinase...
  92. ncbi The A-kinase anchoring domain of type IIalpha cAMP-dependent protein kinase is highly helical
    M G Newlon
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093 0359, USA
    J Biol Chem 272:23637-44. 1997
    ..The assignments and secondary structure analysis provide the basis for analyzing the structure and dynamics of the dimerization domain both free and complexed with specific anchoring proteins...
  93. pmc Type II regulatory subunits are not required for the anchoring-dependent modulation of Ca2+ channel activity by cAMP-dependent protein kinase
    K A Burton
    Department of Pharmacology, University of Washington School of Medicine, Box 357750, Seattle, WA 98195 7750, USA
    Proc Natl Acad Sci U S A 94:11067-72. 1997
    ..The potentiation of the L-type Ca2+ channel in RIIalpha knockout mouse skeletal muscle suggests that, despite a lower affinity for AKAP binding, RIalpha is capable of physiologically relevant anchoring interactions...
  94. ncbi Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways
    R Zidovetzki
    Department of Biology and Neuroscience, University of California, Riverside 92521, USA
    AIDS Res Hum Retroviruses 14:825-33. 1998
    ..Both the Tat-induced increase in intracellular cAMP and IL-6 mRNA levels in CNS-ECs may play a role in altering the blood-brain barrier and thereby inducing pathology often observed in AIDS dementia...
  95. ncbi Mapping of the gene encoding the regulatory subunit RII alpha of cAMP-dependent protein kinase (locus PRKAR2A) to human chromosome region 3p21.3-p21.2
    K Tasken
    Institute of Medical Biochemistry, University of Oslo, Norway
    Genomics 50:378-81. 1998
    ..chromosomal localization of the gene for the regulatory subunit RII alpha of cAMP-dependent protein kinase (locus PRKAR2A) to human chromosome 3 using polymerase chain reaction (PCR) and Southern blot analysis of two different somatic ..
  96. ncbi Characterization of a novel giant scaffolding protein, CG-NAP, that anchors multiple signaling enzymes to centrosome and the golgi apparatus
    M Takahashi
    Department of Biology, Faculty of Science, Kobe University, Kobe 657 8501, Japan
    J Biol Chem 274:17267-74. 1999
    ....
  97. ncbi Analysis of A-kinase anchoring protein (AKAP) interaction with protein kinase A (PKA) regulatory subunits: PKA isoform specificity in AKAP binding
    F W Herberg
    Ruhr Universitat Bochum, Bochum, 44801, Germany
    J Mol Biol 298:329-39. 2000
    ....
  98. ncbi Identification of sperm-specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II regulatory subunit of PKA
    D W Carr
    Veterans Affairs Medical Center and Oregon Health Sciences University, Portland, Oregon 97201, USA
    J Biol Chem 276:17332-8. 2001
    ..These data suggest that sperm contains several proteins that bind to AKAPs in a manner similar to RII and imply that AKAPs may have additional and perhaps unique functions in spermatozoa...
  99. pmc mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module
    K L Dodge
    Howard Hughes Medical Institute and Vollum Institute, and Department of Pediatrics, Oregon Health Sciences University, Portland, OR 97201 3098, USA
    EMBO J 20:1921-30. 2001
    ..Disruption of PKA- mAKAP interaction prevents this enhancement of PDE4D3 activity, suggesting that the proximity of both enzymes in the mAKAP signaling complex forms a negative feedback loop to restore basal cAMP levels...
  100. ncbi Intracellular distribution of gravin, a PKA and PKC binding protein, in vascular endothelial cells
    B D Grove
    Department of Anatomy and Cellular Biology, University of North Dakota, School of Medicine and Health Sciences, Grand Forks, N Dak, USA
    J Vasc Res 38:163-75. 2001
    ....
  101. ncbi A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta
    Chie Tanji
    Department of Biochemistry, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3, Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    J Biol Chem 277:36955-61. 2002
    ..These results suggest that PKA and PP1 regulate the activity of GSK-3beta efficiently by forming a complex with AKAP220...

Research Grants6

  1. Regulation of glucose homeostasis by prokineticin 2 signaling
    Qun Yong Zhou; Fiscal Year: 2012
    ..activation of two cognate G protein-coupled receptors, prokineticin receptor 1 (PKR1) and prokineticin receptor 2 (PKR2). PK2 as well as PKR1 and PKR2 are expressed in pancreatic beta-cells...
  2. MECHANISM OF ACTION OF DIFFERENTIATION AGENTS
    Michael Brattain; Fiscal Year: 2008
    ..Aim 3 will utilize SmadS and Smad2 knockdown cells to determine whether the SmadS/AKT node is linked to invasion and/or metastasis using orthotopic implantation models of colon cancer. ..
  3. INTESTINAL ADENOSINE A2B RECEPTOR
    Shanthi Sitaraman; Fiscal Year: 2004
    ..Third, I will study the role of adenosine receptor in the modulation and feedback regulation of neutrophil-epithelial interaction including transmigration and chemokine secretion. ..
  4. Characterization of intestinal adenosine A2b receptor
    Shanthi Sitaraman; Fiscal Year: 2004
    ..Specific aim 3: We will study: i) the effect of IL-6 on degranulation of neutrophils. ..
  5. Mutations in PKA gene transcripts of lupus T cells
    Dama Laxminarayana; Fiscal Year: 2007
    ..abstract_text> ..
  6. PROTEIN KINASE A ANCHORING IN SPERMATOZOAN FUNCTION
    Daniel W Carr; Fiscal Year: 2010
    ..Knowledge gained from these studies may also be useful for the diagnosis and treatment of patients with defects in sperm movement and fertility. ..