PRKAR1A

Summary

Gene Symbol: PRKAR1A
Description: protein kinase cAMP-dependent type I regulatory subunit alpha
Alias: ACRDYS1, ADOHR, CAR, CNC, CNC1, PKR1, PPNAD1, PRKAR1, TSE1, cAMP-dependent protein kinase type I-alpha regulatory subunit, Carney complex type 1, cAMP-dependent protein kinase regulatory subunit RIalpha, cAMP-dependent protein kinase type I-alpha regulatory chain, protein kinase A type 1a regulatory subunit, protein kinase, cAMP-dependent, regulatory subunit type I alpha, protein kinase, cAMP-dependent, regulatory, type I, alpha, tissue-specific extinguisher 1
Species: human

Top Publications

  1. ncbi The CADCAM contribution to customized orthopaedic implants
    H V Crawford
    Department of Biomedical Engineering, Institute of Orthopaedics, Stanmore, Middlesex
    Proc Inst Mech Eng H 206:43-6. 1992
  2. doi Expression of endometrial protein kinase a during early pregnancy in bonnet monkeys (Macaca radiata)
    Gracy Xavier Rosario
    Primate Biology Division, National Institute for Research in Reproductive Health, Indian Council of Medical Research, Mumbai, Maharashtra, India
    Biol Reprod 81:1172-81. 2009
  3. doi Wnt/beta-catenin and 3',5'-cyclic adenosine 5'-monophosphate/protein kinase A signaling pathways alterations and somatic beta-catenin gene mutations in the progression of adrenocortical tumors
    Sebastien Gaujoux
    Service des Maladies Endocriniennes et Metaboliques, Hopital Cochin, 75014 Paris, France
    J Clin Endocrinol Metab 93:4135-40. 2008
  4. ncbi The human gene for the regulatory subunit RI alpha of cyclic adenosine 3', 5'-monophosphate-dependent protein kinase: two distinct promoters provide differential regulation of alternately spliced messenger ribonucleic acids
    R Solberg
    Institute of Medical Biochemistry, University of Oslo, Norway
    Endocrinology 138:169-81. 1997
  5. pmc The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix
    S Swingler
    Infectious Disease Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Virol 71:4372-7. 1997
  6. ncbi HIV-1 gp120 induces anergy in naive T lymphocytes through CD4-independent protein kinase-A-mediated signaling
    Anna Maria Masci
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, 5 Via S Pansini, I 80131 Naples, Italy
    J Leukoc Biol 74:1117-24. 2003
  7. doi Phosphorylation of APOBEC3G by protein kinase A regulates its interaction with HIV-1 Vif
    Kotaro Shirakawa
    Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawaracho, Sakyo ku, Kyoto 606 8507, Japan
    Nat Struct Mol Biol 15:1184-91. 2008
  8. doi Inactivation of the Carney complex gene 1 (protein kinase A regulatory subunit 1A) inhibits SMAD3 expression and TGF beta-stimulated apoptosis in adrenocortical cells
    Bruno Ragazzon
    Institut Cochin, Universite Paris Descartes, Centre National de la Recherche Scientifique UMR 8104, Paris, France
    Cancer Res 69:7278-84. 2009
  9. doi Viral genetic determinants of nonprogressive HIV type 1 subtype C infection in antiretroviral drug-naive children
    D B Tzitzivacos
    HIV Pathogenesis Research Laboratory, Department of Molecular Medicine and Haematology, University of the Witwatersrand Medical School, Parktown, Johannesburg 2193, South Africa
    AIDS Res Hum Retroviruses 25:1141-8. 2009
  10. pmc Protein kinase A phosphorylation activates Vpr-induced cell cycle arrest during human immunodeficiency virus type 1 infection
    R Anthony Barnitz
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Dr, Bethesda, MD 20892 1892, USA
    J Virol 84:6410-24. 2010

Research Grants

  1. Southeastern Michigan Parkinson's Disease Program
    Peter LeWitt; Fiscal Year: 2006
  2. Role of actin cytoskeleton regulators in craniofacial development and disease
    Shuyi Nie; Fiscal Year: 2013
  3. Sophie Astrof; Fiscal Year: 2016
  4. Steven Farnsworth; Fiscal Year: 2016
  5. Pax genes in cardiac development
    ZACHARY PAUL NEEB; Fiscal Year: 2012
  6. Molecular Genetics of Carney Complex
    Cathy J Hatcher; Fiscal Year: 2010
  7. TGF-BETA SIGNALING IN PALATOGENESIS
    Mark M Urata; Fiscal Year: 2012
  8. MOLECULAR REGULATORY MECHANISM OF TONGUE MORPHOGENESIS
    Yang Chai; Fiscal Year: 2013
  9. Eve Donnelly; Fiscal Year: 2016
  10. DOMINIQUE R ALFANDARI; Fiscal Year: 2016

Patents

  1. COMPLENTARY DNA PROBES FOR HUMAN REGULATORY SUBUNITS (RI alpha AND RII beta) OF cAMP-DEPENDENT PROTEIN KINASES

Detail Information

Publications347 found, 100 shown here

  1. ncbi The CADCAM contribution to customized orthopaedic implants
    H V Crawford
    Department of Biomedical Engineering, Institute of Orthopaedics, Stanmore, Middlesex
    Proc Inst Mech Eng H 206:43-6. 1992
    ..Femoral canal shape is calculated and the optimal implant designed and manufactured from titanium alloy on the Department's CNC (computer numerically controlled) machines.
  2. doi Expression of endometrial protein kinase a during early pregnancy in bonnet monkeys (Macaca radiata)
    Gracy Xavier Rosario
    Primate Biology Division, National Institute for Research in Reproductive Health, Indian Council of Medical Research, Mumbai, Maharashtra, India
    Biol Reprod 81:1172-81. 2009
    ..to intron 6 of cAMP-dependent protein kinase A (PKA) regulatory type I alpha (tissue-specific extinguisher 1) (PRKAR1A). The increased expression of this fragment in gestational endometrium was confirmed by quantitative PCR studies...
  3. doi Wnt/beta-catenin and 3',5'-cyclic adenosine 5'-monophosphate/protein kinase A signaling pathways alterations and somatic beta-catenin gene mutations in the progression of adrenocortical tumors
    Sebastien Gaujoux
    Service des Maladies Endocriniennes et Metaboliques, Hopital Cochin, 75014 Paris, France
    J Clin Endocrinol Metab 93:4135-40. 2008
    ..b>PRKAR1A mutations leading to cAMP pathway dysregulation are observed in primary pigmented nodular adrenocortical diseases ..
  4. ncbi The human gene for the regulatory subunit RI alpha of cyclic adenosine 3', 5'-monophosphate-dependent protein kinase: two distinct promoters provide differential regulation of alternately spliced messenger ribonucleic acids
    R Solberg
    Institute of Medical Biochemistry, University of Oslo, Norway
    Endocrinology 138:169-81. 1997
    ..Transfection of these constructs into rat GH4C1 cells demonstrated that both constructs had promoter activities, as evidenced by high levels of chloramphenicol acetyltransferase activity...
  5. pmc The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix
    S Swingler
    Infectious Disease Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Virol 71:4372-7. 1997
    ..Recombinant p21-activated kinase hPAK65, a recently proposed relative of the Nef-associated kinase, achieved a comparable result. Taken together, these data suggest that MA is a target of the Nef-associated serine kinase...
  6. ncbi HIV-1 gp120 induces anergy in naive T lymphocytes through CD4-independent protein kinase-A-mediated signaling
    Anna Maria Masci
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, 5 Via S Pansini, I 80131 Naples, Italy
    J Leukoc Biol 74:1117-24. 2003
    ..These findings reveal a novel mechanism by which HIVenv may modulate the processes of clonal expansion, homeostatic proliferation, and terminal differentiation of the naive T lymphocyte subset...
  7. doi Phosphorylation of APOBEC3G by protein kinase A regulates its interaction with HIV-1 Vif
    Kotaro Shirakawa
    Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawaracho, Sakyo ku, Kyoto 606 8507, Japan
    Nat Struct Mol Biol 15:1184-91. 2008
    ..These data imply that PKA-mediated phosphorylation of A3G can regulate the interaction between A3G and Vif...
  8. doi Inactivation of the Carney complex gene 1 (protein kinase A regulatory subunit 1A) inhibits SMAD3 expression and TGF beta-stimulated apoptosis in adrenocortical cells
    Bruno Ragazzon
    Institut Cochin, Universite Paris Descartes, Centre National de la Recherche Scientifique UMR 8104, Paris, France
    Cancer Res 69:7278-84. 2009
    ..syndrome resulting from inactivating mutations of the gene encoding the PKA type I alpha regulatory subunit (PRKAR1A). Primary pigmented nodular adrenocortical disease is the most frequent endocrine tumor of CNC...
  9. doi Viral genetic determinants of nonprogressive HIV type 1 subtype C infection in antiretroviral drug-naive children
    D B Tzitzivacos
    HIV Pathogenesis Research Laboratory, Department of Molecular Medicine and Haematology, University of the Witwatersrand Medical School, Parktown, Johannesburg 2193, South Africa
    AIDS Res Hum Retroviruses 25:1141-8. 2009
    ..For example, LT46 Nef is unable to bind AP-1 and AP-2 and therefore is inactive on CD4 endocytosis. The biological relevance of these findings requires further investigation...
  10. pmc Protein kinase A phosphorylation activates Vpr-induced cell cycle arrest during human immunodeficiency virus type 1 infection
    R Anthony Barnitz
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Dr, Bethesda, MD 20892 1892, USA
    J Virol 84:6410-24. 2010
    ..Inhibition of PKA activity during HIV-1 infection abrogates Vpr cell cycle arrest. These findings provide new insight into the signaling event that activates Vpr cell cycle arrest, ultimately leading to the death of infected T cells...
  11. ncbi PrKX is a novel catalytic subunit of the cAMP-dependent protein kinase regulated by the regulatory subunit type I
    B Zimmermann
    Institut fur Physiologische Chemie I, MA 2 40, Abteilung für Biochemie Supramolekularer Systeme, Medizinische Fakultät der Ruhr Universität Bochum, D 44801 Bochum, Germany
    J Biol Chem 274:5370-8. 1999
    ..We discuss how PrKX can modulate the cAMP-mediated signal transduction pathway by preferential binding to the RIalpha subunit and by phosphorylating the RIIalpha subunit in the absence of cAMP...
  12. ncbi Formation of inactive cAMP-saturated holoenzyme of cAMP-dependent protein kinase under physiological conditions
    Reidun Kopperud
    Department of Anatomy and Cell Biology, University of Bergen, N 5009 Bergen, Norway
    J Biol Chem 277:13443-8. 2002
    ..This could be explained by enhanced ternary complex formation. Modulation of ternary complex formation by the level of R subunit may represent a novel way of regulating the cAMP kinase activity in maximally cAMP-stimulated cells...
  13. ncbi Epac1 and cAMP-dependent protein kinase holoenzyme have similar cAMP affinity, but their cAMP domains have distinct structural features and cyclic nucleotide recognition
    Khanh Kim Dao
    Department of Biomedicine, University of Bergen, Norway
    J Biol Chem 281:21500-11. 2006
    ..This helped explain the specificity of current cAMP analogs and, more importantly, lays a foundation for the generation of even more discriminative analogs...
  14. doi In vitro functional studies of naturally occurring pathogenic PRKAR1A mutations that are not subject to nonsense mRNA decay
    Elizabeth L Greene
    Section on Endocrinology and Genetics, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Hum Mutat 29:633-9. 2008
    ..subunit (RIalpha) of adenosine 3',5'-cyclic monophosphate (cyclic AMP [cAMP])-dependent protein kinase (PKA; PRKAR1A)...
  15. ncbi Dissecting the cooperative reassociation of the regulatory and catalytic subunits of cAMP-dependent protein kinase. Role of Trp-196 in the catalytic subunit
    R M Gibson
    Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093 0654, USA
    J Biol Chem 272:31998-2005. 1997
    ..One of these mutants, rR(R333K), having a defect in cAMP binding site B formed a stable complex with rC(W196R) in the absence of cAMP. However, unlike wild-type holoenzyme, this complex was active...
  16. pmc Mutations and polymorphisms in the gene encoding regulatory subunit type 1-alpha of protein kinase A (PRKAR1A): an update
    Anelia Horvath
    Section on Endocrinology and Genetics, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Mutat 31:369-79. 2010
    b>PRKAR1A encodes the regulatory subunit type 1-alpha (RIalpha) of the cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA)...
  17. ncbi alpha-Tocopherol and beta-carotene serum levels in post-menopausal women treated with transdermal estradiol and oral medroxyprogesterone acetate
    C Clemente
    Laboratory of Biochemistry, IRCCS S. De Bellis, Castellana G, Italy
    Horm Metab Res 28:558-61. 1996
    ..Besides, our study has shown that alpha-toc/LDL and beta-car/LDL ratios significatively increased after treatment, while alpha-tocopherol and beta-carotene serum levels did not ..
  18. ncbi Psychosocial job factors, physical workload, and incidence of work-related spinal injury: a 5-year prospective study of urban transit operators
    N Krause
    Division of Epidemiology, School of Public Health, University of California, Berkeley, USA
    Spine (Phila Pa 1976) 23:2507-16. 1998
    ..7-fold reduced risk for spinal injury (OR, 0.37; 95% CI, 0.15-0.93). Cable car crews performing the heaviest physical labor had a threefold increased risk of spinal injury compared with bus ..
  19. ncbi Back pain in a large Canadian police force
    J J Brown
    Department of Medicine, University of Ottawa, Ontario, Canada
    Spine (Phila Pa 1976) 23:821-7. 1998
    ..back pain among Royal Canadian Mounted Police members and to assess the validity of the perception that the patrol car seat and the duty belt are causing a higher rate of low back pain among members of the Royal Canadian Mounted ..
  20. ncbi Malignant mesothelioma in Rome, Italy 1980-1995. A retrospective study of 79 patients
    V Ascoli
    Dipartimento di Medicina Sperimentale e Patologia, , Rome, Italy
    Tumori 82:526-32. 1996
    ..the Latium Region; others were railroad workers, naval mechanics and navy personnel, bakers, explosive workers and car mechanics. A few patients reported indoor exposure to asbestos at home and/or in the workplace...
  21. ncbi Determination of benzene, toluene, ethylbenzene and xylenes in indoor air at environmental levels using diffusive samplers in combination with headspace solid-phase microextraction and high-resolution gas chromatography-flame ionization detection
    K Elke
    , Department of Analytical Chemistry, , Germany
    J Chromatogr A 826:191-200. 1998
    ..Applications such as the determination of BTEXs in indoor air inside buildings, inside a train and a car are presented, indicating the usefulness of the described procedure for short-term measurements of environmental ..
  22. pmc Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR
    W Xie
    Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Genes Dev 14:3014-23. 2000
    ..and genetically to activate CYP3A genes, while similar studies have established constitutive androstane receptor (CAR) as a CYP2B regulator...
  23. ncbi Family history of hypertension and left ventricular mass in youth: possible mediating parameters
    B B Cook
    Department of Pediatrics, Medical College of Georgia, Augusta, USA
    Am J Hypertens 14:351-6. 2001
    ..Hemodynamics were measured at rest and during four stressors (ie, postural change, car driving simulation, video game, forehead cold)...
  24. ncbi The long-range prognosis of arachnoiditis
    D W Guyer
    Vancouver Orthopaedic Group, Washington
    Spine (Phila Pa 1976) 14:1332-41. 1989
    ..Although the majority were able to walk and drive a car without limitation, ability to return to previous full-time occupations was markedly limited...
  25. ncbi [Traumatic tricuspid insufficiency. 5 cases]
    J M Quatre
    Service de cardiologie, , Paris
    Arch Mal Coeur Vaiss 81:325-30. 1988
    ..years) were followed up for 6 to 60 months for tricuspid valve regurgitation caused by a front-to-back injury (in a car in four cases, in an aircraft in one case)...
  26. ncbi Mothers' experience with household roles and social support during the first postpartum year
    D K Gjerdingen
    Department of Family Practice and Community Health, University of Minnesota
    Women Health 21:57-74. 1994
    ..certain household chores (house cleaning, grocery shopping, cooking, washing clothes and dishes, household repairs, car maintenance, and garbage removal)...
  27. ncbi [Significance of a screening questionnaire for diagnosis of sleep apnea]
    T Ploch
    Medizinische Poliklinik, Zeitreihenlabor, , Marburg
    Pneumologie 47:108-11. 1993
    ..pills, hypertension, snoring, involuntary falling asleep, respiratory standstills, tendency to fall asleep during car driving and accidents in which the tendency to fall asleep was also involved...
  28. ncbi Relationships among speech perception, production, language, hearing loss, and age in children with impaired hearing
    P J Blamey
    Department of Otolaryngology, University of Melbourne, Victoria, Australia
    J Speech Lang Hear Res 44:264-85. 2001
    ..Scores on the open-set Consonant-Nucleus-Consonant (CNC) monosyllabic word test and the Bench-Kowal-Bamford (BKB) sentence test were strongly related to language level (as ..
  29. ncbi [A case of heat stroke with cortical laminar necrosis on vascular boundary zones]
    S Akaboshi
    Division of Child Neurology, Faculty of Medicine, Tottori University, Yonago
    No To Hattatsu 28:434-7. 1996
    We report a 10-month-old boy with heat stroke because he was left in a car. He showed hyperthermia, coma and convulsions at the time of his admission...
  30. ncbi Clinical and molecular features of the Carney complex: diagnostic criteria and recommendations for patient evaluation
    C A Stratakis
    Unit on Genetics and Endocrinology, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1862, USA
    J Clin Endocrinol Metab 86:4041-6. 2001
    ..Most recently, at the 17q22-24 locus, the tumor suppressor gene PRKAR1A, coding for the type 1alpha regulatory subunit of PKA, was found to be mutated in approximately half of the known ..
  31. ncbi Ovarian lesions in Carney complex: clinical genetics and possible predisposition to malignancy
    C A Stratakis
    Unit on Genetics and Endocrinology, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1862, USA
    J Clin Endocrinol Metab 85:4359-66. 2000
    Carney complex (CNC) is a familial multiple neoplasia and lentiginosis syndrome (OMIM 160980, http://www.ncbi.nlm.nih...
  32. pmc Cyclic AMP-dependent protein kinase controls virulence of the fungal pathogen Cryptococcus neoformans
    J A Alspaugh
    Departments of Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell Biol 21:3179-91. 2001
    ..pka1 mutant strains were sterile, failed to produce melanin or capsule, and were avirulent. The PKR1 gene encoding the protein kinase A (PKA) regulatory subunit was also identified and disrupted...
  33. ncbi 2,4-Dinitro-3,5,6-trideuterophenylhydrazones for the quantitation of aldehydes and ketones in air samples by liquid chromatography-mass spectrometry
    G Zurek
    , Anorganisch-Chemisches Institut, Abteilung Analytische Chemie, Germany
    J Chromatogr A 869:251-9. 2000
    ..of a series of aldehydes and ketones are applied as internal standards for the determination of the carbonyls in car exhaust samples. Various aldehydes are identified and quantified by MS detection...
  34. pmc In vitro and in vivo characterization of NK3 receptors in the rabbit eye by use of selective non-peptide NK3 receptor antagonists
    A D Medhurst
    Department of Neurosciences Research, SmithKline Beecham Pharmaceuticals, Harlow, Essex
    Br J Pharmacol 122:469-76. 1997
    ..4, slope=1.8+/-0.3, n=4). SB 222200 ((-)-(S)-N-(alpha-ethylbenzyl)-3-methyl-2-phenylquinoline-4-car box amide; 30-300 nM, pA2=7.9, slope=1.4+/-0...
  35. ncbi We are chronically sleep deprived
    M H Bonnet
    Dayton Veterans Affairs Medical Center, Wright State University, Ohio, USA
    Sleep 18:908-11. 1995
    ..surprising that fatigue is a factor in 57% of accidents leading to the death of a truck driver and in 10% of fatal car accidents and results in costs of up to 56 billion dollars per year...
  36. ncbi Distraction lengthening of the ulna in radial club hand using the Ilizarov technique
    M A Pickford
    Christine M Kleinert Institute for Hand and Micro Surgery, Louisville, Kentucky 40202, USA
    J Hand Surg Br 23:186-91. 1998
    ..can enhance the ability to perform normal activities of daily living, such as reaching the perineum or driving a car, but complications are extremely common...
  37. ncbi Clinical evaluation of higher stimulation rates in the nucleus research platform 8 system
    Kerrie Plant
    Cooperative Research Centre for Cochlear Implant and Hearing Aid Innovation, Melbourne, Australia
    Ear Hear 28:381-93. 2007
    ..This system enabled clinical investigation of higher stimulation rates before an implementation in the Freedom cochlear implant system commercially released by Cochlear Limited...
  38. doi Update on familial pituitary tumors: from multiple endocrine neoplasia type 1 to familial isolated pituitary adenoma
    Adrian F Daly
    Department of Endocrinology, Centre Hospitalier Universitaire de Liege, University of Liege, Liege, Belgium
    Horm Res 71:105-11. 2009
    ..5% of all cases and over half of these are due to multiple endocrine neoplasia type 1 (MEN1) and Carney complex (CNC)...
  39. ncbi Genetic analysis in a patient with recurrent cardiac myxoma and endocrinopathy
    Yasushi Imai
    Department of Cardiovascular Medicine, University of Tokyo, Tokyo, Japan
    Circ J 69:994-5. 2005
    ..in exon 2 in a heterozygous fashion in the causative gene of CNC, protein kinase A regulatory subunit 1 alpha (PRKAR1A). This genetic mutation is thought to cause haplo-insufficiency of PRKAR1A resulting in tumorigenesis...
  40. ncbi Speech perception for adults who use hearing aids in conjunction with cochlear implants in opposite ears
    Mansze Mok
    Department of Otolaryngology, The University of Melbourne, Melbourne, Victoria, Australia
    J Speech Lang Hear Res 49:338-51. 2006
    ..Three speech perception tests were used: consonant-vowel nucleus-consonant (CNC) words in quiet, City University of New York style (CUNY) sentences in coincident signal and noise, and spondees in ..
  41. doi Reproductive disturbances in multiple neuroendocrine tumor syndromes
    Aristides Lytras
    Division of Endocrinology and Metabolism, Hippocrateion General Hospital, Vas Sofias 108, Athens, Greece
    Endocr Relat Cancer 16:1125-38. 2009
    ..male feminization is a feature of McCune-Albright syndrome (MAS), neurofibromatosis type 1 (NF1), Carney complex (CNC), and Peutz-Jeghers syndrome (PJS), while sperm maturation and ovulation defects have been described in MAS and CNC...
  42. ncbi Self-administration of cocaine increases the release of acetylcholine to a greater extent than response-independent cocaine in the nucleus accumbens of rats
    G P Mark
    Department of Behavioral Neuroscience, L470, Oregon Health Sciences University, School of Medicine, Portland 97201, USA
    Psychopharmacology (Berl) 143:47-53. 1999
    ..A useful method for examining this issue is to compare neurotransmitter release following response-dependent, or self-administered, drug exposure and response-independent exposure...
  43. ncbi Optimizing the benefit of sound processors coupled to personal FM systems
    Jace Wolfe
    Hearts for Hearing Foundation, USA
    J Am Acad Audiol 19:585-94. 2008
    ..There are, however, a number of adjustable parameters of the cochlear implant and FM receiver that may affect performance and benefit, and there is limited evidence to guide audiologists in optimizing these parameters...
  44. ncbi Validity of patient reporting and predictive value of industrial physical work demands
    I Lindström
    Department of Orthopaedics, University of Goteborg, Sahlgren Hospital, Sweden
    Spine (Phila Pa 1976) 19:888-93. 1994
    This prospective study analyzed industrial physical work demands. The patients (n = 103), sick-listed 8 weeks because of low back pain, were industrial blue-collar workers in the car manufacturing industry.
  45. ncbi High-dose methylprednisolone prevents extensive sick leave after whiplash injury. A prospective, randomized, double-blind study
    K Pettersson
    Department of Orthopaedics, , Sweden
    Spine (Phila Pa 1976) 23:984-9. 1998
    ..This procedure was also adopted in a randomized study of cases of whiplash injury in car accidents...
  46. ncbi Evaluation "in-car" countermeasures to sleepiness: cold air and radio
    L A Reyner
    Sleep Research Laboratory, Loughborough University, UK
    Sleep 21:46-50. 1998
    The efficacy of putative "in-car" countermeasures to driver sleepiness is unknown...
  47. ncbi [A clinicopathological and prognostic study of 22 cases central neurocytoma]
    Nanyun Li
    Department of Pathology, Nanjing General Hospital of PLA, Nanjing 210002, China Email
    Zhonghua Bing Li Xue Za Zhi 31:12-5. 2002
    To investigate the clinicopathological features and prognosis of 22 cases of central neurocytoma (CNC), representing 0.48% of a series of 4 528 patients undergoing biopsy for central nervous system tumors.
  48. pmc Optimizing the perception of soft speech and speech in noise with the Advanced Bionics cochlear implant system
    Laura K Holden
    Washington University School of Medicine, Department of Otolaryngology, St Louis, MO 63110, USA
    Int J Audiol 50:255-69. 2011
    ..This study aimed to provide guidelines to optimize perception of soft speech and speech in noise for Advanced Bionics cochlear implant (CI) users...
  49. doi Heterogeneity of skin manifestations in patients with Carney complex
    Christine Mateus
    Department of Dermatology, Pavillon Tarnier, Hopital Cochin, APHP and Faculté de Médecine Paris V, Universite Rene Descartes, Paris, France
    J Am Acad Dermatol 59:801-10. 2008
    ..Carney complex is an autosomal dominant endocrine disorder associated with skin involvement...
  50. doi Understanding the mechanisms of entrapment neuropathies. Review article
    Khoa Pham
    Department of Orthopaedic Surgery, University of California, Irvine, California, USA
    Neurosurg Focus 26:E7. 2009
    ..been created to help investigators understand the molecular and cellular pathogenesis of chronic nerve compression (CNC) injury...
  51. pmc Modulation of cytosolic sexual steroid receptors in autochthonous methylnitrosourea-induced rat mammary carcinoma following application of 2-chloroethylnitrosocarbamoyl-L-alanine linked to oestradiol or dihydrotestosterone
    R Corr
    Institute of Toxicology and Chemotherapy, German Cancer Research Centre, Heidelberg, FRG
    Br J Cancer 62:42-7. 1990
    This study concentrated on the influence of 2-chloroethylnitrosocarbamoyl-L-alanine (CNC-L-ala) linked to oestradiol (CNA-L-ala-E2) or dihydrotestosterone (CNC-L-ala-DHT) in position 17 of the respective steroid hormone on tumour growth ..
  52. ncbi The role of Pitx2 during cardiac development. Linking left-right signaling and congenital heart diseases
    Diego Franco
    Department of Experimental Biology, University of Jaen, Jaen, Spain
    Trends Cardiovasc Med 13:157-63. 2003
    ..during cardiogenesis is conducted within three different cell types: the myocardium, the cardiac neural crest (CNC) cells, and the pharyngeal arch mesenchyme...
  53. ncbi Analysis of diaphragm movement during tidal breathing and during its activation while breath holding using MRI synchronized with spirometry
    P Kolar
    Department of Rehabilitation, Second Medical Faculty, Charles University, Motol, Czech Republic
    Physiol Res 58:383-92. 2009
    ..48, te2.24, fa90, tse1, fov 328)...
  54. ncbi Bisegmental rotational fracture dislocation of the pediatric cervical spine. A case report
    R F Hoffmann
    Humboldt University of Berlin, Virchow Clinic, Department of Trauma and Reconstructive Surgery, Berlin, Germany
    Spine (Phila Pa 1976) 24:904-7. 1999
    ..METHODS: A 6-year-old girl was hit by a car as a pedestrian...
  55. ncbi A patient-reported comparison of trapeziectomy with Swanson Silastic implant or sling ligament reconstruction
    M E Lovell
    Centre for Upper Limb Surgery, Wrightington Hospital, Appley Bridge, UK
    J Hand Surg Br 24:453-5. 1999
    ..significantly better results were obtained for pain at 1 year, carrying a milk bottle and taking a handbrake off a car, and overall function...
  56. doi The effect of instantaneous input dynamic range setting on the speech perception of children with the nucleus 24 implant
    Lisa S Davidson
    Department of Otolaryngology Head and Neck Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Ear Hear 30:340-9. 2009
    ..In addition, children's ability to understand soft and conversational level speech in relation to aided sound-field thresholds was examined...
  57. ncbi Decreased width of the spinal canal in patients with chronic symptoms after whiplash injury
    K Pettersson
    Department of Orthopaedics, University Hospital of Northern Sweden, , Sweden
    Spine (Phila Pa 1976) 20:1664-7. 1995
    ..METHODS. Forty-eight consecutive patients were evaluated for whiplash trauma after car accidents...
  58. ncbi Xenopus ADAM 13 is a metalloprotease required for cranial neural crest-cell migration
    D Alfandari
    Laboratoire de Biologie Moléculaire et Cellulaire du Developpement, Equipe Adhesion et Migration Cellulaires, 9 quai St Bernard Bat C, 7 degrees etage, 75005, Paris, France
    Curr Biol 11:918-30. 2001
    Cranial neural-crest (CNC) cells originate from the lateral edge of the anterior neuroepithelium and migrate to form parts of the peripheral nervous system, muscles, cartilage, and bones of the face...
  59. ncbi LEF1 is a critical epithelial survival factor during tooth morphogenesis
    Tomoyo Sasaki
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
    Dev Biol 278:130-43. 2005
    ..Wnt signaling is known to be critical for the specification of cranial neural crest (CNC) cells and may regulate the fate diversity of the CNC during craniofacial morphogenesis...
  60. ncbi Cardiac neural crest ablation alters aortic smooth muscle force and voltage-sensitive Ca2+ responses
    Christopher J Wingard
    Department of Physiology, Medical College of Georgia, 1120 15th Street, Room CL3120, Augusta, GA 30912, USA
    J Muscle Res Cell Motil 23:293-303. 2002
    Ablation of the premigratory cardiac neural crest (CNC) from the chick embryo results in a malformed outflow tract vasculature termed persistent truncus arteriosus (PTA)...
  61. ncbi Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis
    Y Chai
    Center for Craniofacial Molecular Biology School of Dentistry University of Southern California, CSA 103, Los Angeles, CA 90033, USA
    Development 127:1671-9. 2000
    ..genetic system, we have systematically followed the migration and differentiation of the cranial neural crest (CNC) cells from E9.5 to 6 weeks after birth...
  62. doi Direct electrochemistry and electrocatalysis of hemoglobin in nafion/carbon nanochip film on glassy carbon electrode
    Sini George
    Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543
    J Phys Chem B 113:15445-54. 2009
    ..Ultraviolet-visible and Fourier transform infrared spectroscopy showed that Hb immobilized in the CNC film remained in its native structure...
  63. doi Carney complex: a clinicopathologic and molecular biological study of a sporadic case, including extracutaneous and cutaneous lesions and a novel mutation of the PRKAR1A gene
    Denisa Kacerovska
    Sikl s Department of Pathology, Charles University, Medical Faculty Hospital, Alej Svobody 80, Pilsen, Czech Republic
    J Am Acad Dermatol 61:80-7. 2009
    Carney complex (CNC) is an autosomal dominant disorder associated with multiple neoplasms.
  64. ncbi Chiral beta-cyclodextrin-based polymer supports prepared via ring-opening metathesis graft-polymerization
    B Mayr
    Institute of Analytical Chemistry and Radiochemistry, University of Innsbruck, Austria
    J Chromatogr A 907:47-56. 2001
    ..1), tetrakis(6-O-norborn-2-ene-5-carboxyl)-beta-CD (2), (3), 6-O-(6-norborn-2-ene-5-car-6-O-(7-oxanorborn-2-ene-5-carboxyl)-beta-CD bonylaminohexoyl)-beta-CD (4), 6-O-(norborn-2-ene-5-..
  65. ncbi Acute treatment of whiplash neck sprain injuries. A randomized trial of treatment during the first 14 days after a car accident
    G E Borchgrevink
    Emergency Clinic, University Hospital, Trondheim, Norway
    Spine (Phila Pa 1976) 23:25-31. 1998
    ..of whiplash neck sprain injuries in patients treated with two different regimes during the first 14 days after the car accident. Patients in the first group were encouraged to act as usual, i.e...
  66. pmc Carney complex (CNC)
    Jerome Bertherat
    Centre de Référence Maladies Rares de la Surrénale, Service d endocrinologie, Hopital Cochin, INSERM U 567, CNRS UMR 8104, Institut Cochin, Universite Rene Descartes Paris 5, Paris, 75014, France
    Orphanet J Rare Dis 1:21. 2006
    ..One of the putative CNC genes located on 17q22-24, (PRKAR1A), has been identified to encode the regulatory subunit (R1A) of protein kinase A...
  67. doi Up-regulation of endocrine gland-derived vascular endothelial growth factor but not vascular endothelial growth factor in human ectopic endometriotic tissue
    Kai Fai Lee
    Department of Obstetrics and Gynecology, The University of Hong Kong, Pokfulam, Hong Kong, People s Republic of China
    Fertil Steril 93:1052-60. 2010
    To study the expression of vascular endothelial growth factor (VEGF), endocrine gland-derived VEGF (EG-VEGF/PK1), and its receptors (PKR1 and PKR2) in eutopic and ectopic endometrial tissues.
  68. doi Expressing Hoxa2 across the entire endochondral skeleton alters the shape of the skeletal template in a spatially restricted fashion
    Sara Tavella
    Dipartimento di Oncologia, Biologia e Genetica, Universita di Genova, Italy
    Differentiation 79:194-202. 2010
    ..The head skeleton of vertebrates is formed by cranial neural crest (CNC), and mainly by a Hox-free domain of the CNC...
  69. ncbi Haemodynamic changes in patients with whiplash injury measured by transcranial Doppler sonography (TCD)
    V Seric
    Department of Neurology, Sestre Milosrdnice University Hospital, Zagreb, Croatia
    Coll Antropol 24:197-204. 2000
    ..of vertebrobasilar circulation in patients with a whiplash injury of the cervical spine, that occurred mostly in car accident...
  70. ncbi moz regulates Hox expression and pharyngeal segmental identity in zebrafish
    Craig T Miller
    Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403, USA
    Development 131:2443-61. 2004
    In vertebrate embryos, streams of cranial neural crest (CNC) cells migrate to form segmental pharyngeal arches and differentiate into segment-specific parts of the facial skeleton...
  71. ncbi TGFbeta-mediated FGF signaling is crucial for regulating cranial neural crest cell proliferation during frontal bone development
    Tomoyo Sasaki
    Center for Craniofacial Molecular Biology School of Dentistry University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
    Development 133:371-81. 2006
    The murine frontal bone derives entirely from the cranial neural crest (CNC) and consists of the calvarial (lateral) aspect that covers the frontal lobe of brain and the orbital aspect that forms the roof of bony orbit...
  72. ncbi Placental expression of EG-VEGF and its receptors PKR1 (prokineticin receptor-1) and PKR2 throughout mouse gestation
    P Hoffmann
    INSERM, Unité 878, Grenoble, France
    Placenta 28:1049-58. 2007
    ..We investigated the pattern of expression of EG-VEGF and its receptors, PKR1 and PKR2 at the mRNA and protein levels...
  73. ncbi Sick leave and disability pension among passenger car occupants injured in urban traffic
    P O Bylund
    , Department of Surgery, , Sweden
    Spine (Phila Pa 1976) 23:1023-8. 1998
    STUDY DESIGN: A follow-up cohort study of passenger car occupants injured in car crashes in an urban area in Sweden. OBJECTIVES: To analyze the injuries, injury events, and long-term consequences of injuries in car crashes...
  74. ncbi Asbestos exposure, physical activity and colon cancer: a case-control study
    P Vineis
    Dipartimento di Scienze Biomediche e Oncologia Umana, Main Hospital and University of Torino, Italy
    Tumori 79:301-3. 1993
    AIMS AND BACKGROUND: An association between colon cancer and the occupation of model or pattern maker in the car industry has been repeatedly suggested...
  75. ncbi Mectizan delivery systems and cost recovery in the Central African Republic
    A D Hopkins
    , Bangui, Central African Republic
    Ann Trop Med Parasitol 92:S97-100. 1998
    The Central African Republic (CAR) has a serious onchocerciasis problem. The disease is endemic in three quarters of the country and there is considerable onchocercal blindness in the north-west...
  76. ncbi Ca(2+)-evoked serotonin secretion by parafollicular cells: roles in signal transduction of phosphatidylinositol 3'-kinase, and the gamma and zeta isoforms of protein kinase C
    K Liu
    Division of Neuroscience, New York State Psychiatric Institute, New York, New York 10032, USA
    J Neurosci 20:1365-73. 2000
    Parafollicular (PF) cells secrete 5-HT in response to stimulation of a G-protein-coupled Ca(2+) receptor (CaR) by increased extracellular Ca(2+) (upward arrow[Ca(2+)](e))...
  77. ncbi Central neurocytoma: a clinicopathological and neuroradiological study
    Bo Zhang
    Department of Radiology, the First Affiliated Hospital of Sun Yat Sen University, Guangzhou, 510080, China
    Neuroradiology 46:888-95. 2004
    Central neurocytoma (CNC) is an uncommon benign tumor of the central nervous system (CNS) occurring in adults and is more likely to be located in the region of the foramina of Monra...
  78. ncbi Clinical evaluation of expanded input dynamic range in Nucleus cochlear implants
    P W Dawson
    Cooperative Research Centre for Cochlear Implant and Hearing Aid Innovation, Melbourne, Victoria, Australia
    Ear Hear 28:163-76. 2007
    ..The aim of this study was to investigate whether expanded instantaneous input dynamic ranges (IIDRs) in the Nucleus cochlear implant system benefit speech perception in the laboratory and listening in the real world...
  79. pmc An Intronic mutation is associated with prolactinoma in a young boy, decreased penetrance in his large family, and variable effects on MEN1 mRNA and protein
    L Drori-Herishanu
    Section of Endocrinology and Genetics, Program on Developmental Endocrinology Genetics PDEGEN, NIH, Bethesda, Maryland 20892, USA
    Horm Metab Res 41:630-4. 2009
    ..in a young child may be due to sequence variants in genes that are known to cause these tumors ( MEN1, PRKAR1A, AIP). An 11-year-old boy with a macroprolactinoma was treated with cabergoline and the tumor receded...
  80. pmc ACTH-independent Cushing's syndrome with bilateral micronodular adrenal hyperplasia and ectopic adrenocortical adenoma
    Estelle Louiset
    Institut National de la Sante et de la Recherche Medicale, Unité 982 Equipe Associée 4310, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institut Fédératif de Recherches Multidisciplinaires sur les Peptides 23, University of Rouen, 76821 Mont Saint Aignan, France
    J Clin Endocrinol Metab 95:18-24. 2010
    ..Bilateral micronodular adrenal hyperplasia and ectopic adrenocortical adenoma are two rare causes of ACTH-independent Cushing's syndrome...
  81. doi Large cell calcifying Sertoli cell tumor: a clinicopathologic study of 1 malignant and 3 benign tumors using histomorphology, immunohistochemistry, ultrastructure, comparative genomic hybridization, and polymerase chain reaction analysis of the PRKAR1A ge
    Fredrik Petersson
    Department of Pathology, National University Health System, Singapore 119074, Singapore
    Hum Pathol 41:552-9. 2010
    ..Analysis of PRKAR1A gene was performed on 2 cases. The age range of the patients was 19 to 54 years...
  82. doi Expression of heme oxygenase-1 in human leukemic cells and its regulation by transcriptional repressor Bach1
    Takuya Miyazaki
    Department of Internal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Cancer Sci 101:1409-16. 2010
    ..of leukemic cells and normal monocytes, and its regulatory mechanism by the transcriptional repressor, BTB and CNC homology 1 (Bach1), and the activator, nuclear factor erythroid-derived 2 related factor 2 (Nrf2)...
  83. ncbi Genetics of Peutz-Jeghers syndrome, Carney complex and other familial lentiginoses
    C A Stratakis
    Unit on Genetics and Endocrinology, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1862, USA
    Horm Res 54:334-43. 2000
    Peutz-Jeghers syndrome (PJS, #175200) and Carney complex (CNC, OMIM#160980) are the two most common multiple neoplasia syndromes associated with lentiginosis...
  84. ncbi Mutation of perinatal myosin heavy chain associated with a Carney complex variant
    Mark Veugelers
    Molecular Cardiology Laboratory, Greenberg Cardiology Division, Department of Medicine, Weill Medical College of Cornell University, New York 10021, USA
    N Engl J Med 351:460-9. 2004
    Familial cardiac myxomas occur in the hereditary syndrome Carney complex. Although PRKAR1A mutations can cause the Carney complex, the disorder is genetically heterogeneous...
  85. ncbi Familial hyperaldosteronism type II is linked to the chromosome 7p22 region but also shows predicted heterogeneity
    Albertina So
    Endocrine Hypertension Research Centre, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia
    J Hypertens 23:1477-84. 2005
    ..Mutations in the exons or intron-exon boundaries of PRKAR1B (7p22, closely related to PRKAR1A, which is mutated in Carney complex) have been excluded in this family.
  86. ncbi Wnt5a is required for cardiac outflow tract septation in mice
    J Robert Schleiffarth
    Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Pediatr Res 61:386-91. 2007
    ..from the pharyngeal mesoderm referred to as secondary/anterior heart field, whereas cardiac neural crest (CNC) cell-derived mesenchyme condenses to form an aortopulmonary septum...
  87. pmc Pituitary-specific knockout of the Carney complex gene Prkar1a leads to pituitary tumorigenesis
    Zhirong Yin
    Department of Molecular Virology, Immunology, and Molecular Genetics, The Ohio State University, 420 West 12th Avenue, Columbus, OH 43210, USA
    Mol Endocrinol 22:380-7. 2008
    ..To explore the role of loss of the CNC gene PRKAR1A on pituitary tumorigenesis, we produced a tissue-specific knockout (KO) of this gene in the mouse...
  88. doi Prevalence of mutations in TSHR, GNAS, PRKAR1A and RAS genes in a large series of toxic thyroid adenomas from Galicia, an iodine-deficient area in NW Spain
    F Palos-Paz
    Unidade de Enfermedades Tiroideas e Metabólicas UETeM, Complexo Hospitalario Universitary de Santiago CHUS, University of Santiago de Compostela, Santiago de Compostela, 15705, Spain
    Eur J Endocrinol 159:623-31. 2008
    ..We report the first study to investigate mutations in TSHR, GNAS, protein kinase, cAMP-dependent, regulatory, type I alpha (PRKAR1A) and RAS genes, in a large series of TA from Galicia, an iodine-deficient region in NW Spain.
  89. pmc 8-Cl-adenosine inhibits proliferation and causes apoptosis in B-lymphocytes via protein kinase A-dependent and independent effects: implications for treatment of Carney complex-associated tumors
    Audrey J Robinson-White
    Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 94:4061-9. 2009
    ..primarily by spotty skin pigmentation and a variety of endocrine and other tumors, is caused by mutations in PRKAR1A, the gene that codes for the RIalpha subunit of protein kinase A (PKA)...
  90. ncbi Coordinating cognitive information: task effects and individual differences in integrating information from several sources
    P L Yee
    University of Washington
    Cogn Psychol 23:615-80. 1991
    In many tasks people have to coordinate the information from several sources. An example would be driving a car while listening to directions. The driver has to establish a correspondence between a visual picture and verbal instructions...
  91. ncbi Vertebral fracture in a fused spine for scoliosis. A case report
    J Bago
    Department of Orthopedic Surgery and Traumatology, Hospital de Traumatologia Vall d Hebron, Barcelona, Spain
    Spine (Phila Pa 1976) 23:270-2. 1998
    ..A case report...
  92. ncbi The interaction between technical requirements and comfort in care seating
    E Fubini
    Department of Animal Biology, University of Torino, Italy
    Coll Antropol 21:405-27. 1997
    The paper analyses different ergonomic aspects that it is necessary to take into account to design car seats tat can fit users' requirements in terms of safety and comfort, two aspects that are closely related...
  93. ncbi Human small Maf proteins form heterodimers with CNC family transcription factors and recognize the NF-E2 motif
    T Toki
    Department of Pediatrics, Hirosaki University, Japan
    Oncogene 14:1901-10. 1997
    ..binding to NF-E2 sites was found to depend on formation of homodimers or heterodimers with p45 and p45-related CNC family proteins...
  94. ncbi Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene
    J Alam
    Department of Molecular Genetics, Alton Ochsner Medical Foundation, Louisiana State University Medical Center, New Orleans, Louisiana 70121, USA
    J Biol Chem 274:26071-8. 1999
    ..resemble the binding site for the activator protein-1 (Jun/Fos), Maf, and Cap'n'Collar/basic leucine zipper (CNC-bZIP) families of proteins...
  95. ncbi Isolated familial somatotropinomas: establishment of linkage to chromosome 11q13.1-11q13.3 and evidence for a potential second locus at chromosome 2p16-12
    M R Gadelha
    Department of Medicine, University of Illinois at Chicago, 60612, USA
    J Clin Endocrinol Metab 85:707-14. 2000
    ..of an endocrine neoplasia complex that includes multiple endocrine neoplasia type 1 (MEN-1) and Carney complex (CNC) or as isolated familial somatotropinomas (IFS)...
  96. ncbi Impaired expression of glutathione synthetic enzyme genes in mice with targeted deletion of the Nrf2 basic-leucine zipper protein
    J Y Chan
    Department of Laboratory Medicine, University of California San Francisco, 533 Parnassus Ave Room U442, San Francisco, CA 94143 0793, USA
    Biochim Biophys Acta 1517:19-26. 2000
    ..b>CNC-bZIP factors, together with small Maf proteins, have been shown to bind as heterodimers to the NF-E2/AP-1 element, ..
  97. ncbi Sequence analysis of the PRKAR1A gene in sporadic somatotroph and other pituitary tumours
    Gregory A Kaltsas
    Department of Endocrinology, St Bartholomew s Hospital, London EC1A 7BE, UK
    Clin Endocrinol (Oxf) 57:443-8. 2002
    ..One of the genes responsible for CNC, the PRKAR1A gene located on human chromosome 17q22-24, has recently been cloned...
  98. pmc Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2)
    Hewang Li
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:1627-32. 2003
    ..All findings are consistent with a role for BIG2 as an A kinase-anchoring protein (or AKAP) that could coordinate cAMP and ARF regulatory pathways...
  99. ncbi Expression and oxygen regulation of endocrine gland-derived vascular endothelial growth factor/prokineticin-1 and its receptors in human placenta during early pregnancy
    Pascale Hoffmann
    Institut National de la Santé et de la Recherche Médicale EMI 01 05, Département réponse et dynamique cellulaires Laboratoire d Angiogenèse, Commissariat a l Energie Atomique Grenoble, France
    Endocrinology 147:1675-84. 2006
    ..study we investigated the pattern of expression of EG-VEGF, its related factor Bv8/PK2, and their common receptors, PKR1 and PKR2, in human placenta during the first trimester of pregnancy...
  100. ncbi PRKAR1A mutations in primary pigmented nodular adrenocortical disease
    Laure Cazabat
    INSERM U567, Paris, France
    Pituitary 9:211-9. 2006
    ..One of the putative CNC genes has been identified as the gene of the regulatory R1A subunit of protein kinase A (PRKAR1A), located at 17q22-24...
  101. ncbi The microbial ecology of a typical Italian salami during its natural fermentation
    Lucia Aquilanti
    Department of Food Science, Polytechnic University of Marche, Via Brecce Bianche, 60131 Ancona, Italy
    Int J Food Microbiol 120:136-45. 2007
    ..The viable counts revealed a dominance of lactic acid bacteria (LAB) over coagulase negative cocci (CNC) and yeasts. From the molecular identification of the isolates, the prevalence of Lactobacillus curvatus, Lb...

Research Grants76

  1. Southeastern Michigan Parkinson's Disease Program
    Peter LeWitt; Fiscal Year: 2006
    ..sites that will work together closely: the William Beaumont Hospital System, the Clinical Neuroscience Center (CNC), a Parkinson's disease (PD) research and treatment program in Southfield, and the PD clinics at the Wayne ..
  2. Role of actin cytoskeleton regulators in craniofacial development and disease
    Shuyi Nie; Fiscal Year: 2013
    ..Of particular interest, cranial neural crest (CNC) cells migrate throughout the face to form most of the craniofacial skeleton...
  3. Sophie Astrof; Fiscal Year: 2016
    ..We also found that integrin a5 is required for the presence of normal numbers of cardiac neural crest (CNC) cells in the pharyngeal arches...
  4. Steven Farnsworth; Fiscal Year: 2016
    ..For regenerative dentistry goals, deriving cranial neural crest (CNC) cells from iPS cells is an important step for future development of iPS-derived cranial-facial structure ..
  5. Pax genes in cardiac development
    ZACHARY PAUL NEEB; Fiscal Year: 2012
    ..b>CNC derivatives are essential for outflow tract (OFT) septation and remodeling of the pharyngeal arch arteries (AA) to ..
  6. Molecular Genetics of Carney Complex
    Cathy J Hatcher; Fiscal Year: 2010
    ..We have shown that haploinsufficient mutations of the PRKAR1A gene encoding the R1a regulatory subunit of cAMP-dependent protein kinase A cause ~2/3 of CNC...
  7. TGF-BETA SIGNALING IN PALATOGENESIS
    Mark M Urata; Fiscal Year: 2012
    ..Using the Wnt1-Cre/R26R model, our preliminary data shows that there is a deficiency of CNC-derived palatal mesenchyme in Msx1 null mutant mouse embryos...
  8. MOLECULAR REGULATORY MECHANISM OF TONGUE MORPHOGENESIS
    Yang Chai; Fiscal Year: 2013
    ..Specifically, our preliminary studies show that cranial neural crest (CNC) cells contribute to the interstitial connective tissue, which ultimately compartmentalizes both intrinsic and ..
  9. Eve Donnelly; Fiscal Year: 2016
    ..studies, a complex with 31,250 ft2 of open lab space and 27,250 ft2 of core lab space, and includes equipment for CNC milling, mechanical testing, ultra performance liquid chromatography (UPLC), and core facilities for Biochemistry, ..
  10. DOMINIQUE R ALFANDARI; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The migration of cranial neural crest (CNC) cells is controlled by proteins that regulate gene expression, cell proliferation, cell signaling and cell adhesion...
  11. Genevieve Abbruzzese; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): The migration of cranial neural crest (CNC) cells is a critical process for proper formation of the face and jaw during embryo development...
  12. Tooth pulp as a source for neuronal precursor cells to study neurogenetic disorde
    Lawrence T Reiter; Fiscal Year: 2013
    ..Dental pulps from EPT are also an easily obtainable source of cranial neural crest (CNC) cells...
  13. TGF BETA SIGNALING AND CRANIOFACIAL MORPHOGENESIS
    Yang Chai; Fiscal Year: 2009
    ..for inducing apoptosis in the medial edge epithelium (MEE) and cell proliferation in the cranial neural crest (CNC)-derived palatal mesenchyme, both of which are crucial for normal palatal fusion...
  14. Characterization of neural crest gene expression using a new transgenic Xenopus m
    Shuo Wei; Fiscal Year: 2013
    ..In vertebrates, the majority of craniofacial structures are derived from the cranial neural crest (CNC), and abnormalities in CNC development often lead to craniofacial disorders...
  15. Ranjan Gupta; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Each year, millions of Americans suffer from chronic nerve compression (CNC) injuries such as carpal tunnel syndrome, cubital tunnel syndrome, and spinal nerve root stenosis...
  16. Yang Chai; Fiscal Year: 2016
    ..for inducing apoptosis in the medial edge epithelium (MEE) and cell proliferation in the cranial neural crest (CNC)-derived palatal mesenchyme, both of which are crucial for normal palatal fusion...
  17. ROLE OF MONONUCLEAR LEUKOCYTES IN IMMUNITY
    Samuel Silverstein; Fiscal Year: 2009
    ..stirred suspensions and discovered that a critical PMN concentration (CNC) is required to block the growth of bacteria in fibrin and collagen gels and in stirred suspensions...
  18. Regulation of glucose homeostasis by prokineticin 2 signaling
    Qun Yong Zhou; Fiscal Year: 2012
    ..biological processes via the activation of two cognate G protein-coupled receptors, prokineticin receptor 1 (PKR1) and prokineticin receptor 2 (PKR2). PK2 as well as PKR1 and PKR2 are expressed in pancreatic beta-cells...
  19. RESEARCH ON FUNCTIONAL GENOMICS, IMAGE ANALYSIS AND RESCUE OF CLEFT PALATE
    Yang Chai; Fiscal Year: 2013
    ..of these animal models, we will work closely with several scientists to address the regulatory mechanism of CNC cell fate determination. Specifically, working with Dr...
  20. Lawrence S Kirschner; Fiscal Year: 2016
    ..At the genetic level, CNC is caused by mutations in the PRKAR1A tumor suppressor whereas CS is caused by mutations in the PTEN tumor suppressor...
  21. David J Garfinkel; Fiscal Year: 2014
    ..We discovered a copy number control (CNC) system based on Ty1 antisense (AS) RNAs that inhibits retrotransposition posttranslationally...
  22. The Role of PINCH-1 in Regulating Cardiac Neural Crest Behavior
    Jamie Lohr; Fiscal Year: 2007
    ..A gene highly expressed in the CNC was identified as the LIM family member PINCH-1...
  23. Kelvin J A Davies; Fiscal Year: 2016
    ..elegans and D. melanogaster to H2O2 requires 20S Proteasome and Pa28? expression, via the skn-1 and cnc-C homologs of Nrf2;4)The capacity to adapt to oxidative stress declines in senescent HBE1 and primary NHBE cells, ..
  24. OXYGEN RADICAL TOXICITY AND PROTEIN DEGRADATION
    Kelvin J A Davies; Fiscal Year: 2012
    ..elegans and D. melanogaster to H2O2 requires 20S Proteasome and Pa28? expression, via the skn-1 and cnc-C homologs of Nrf2;4)The capacity to adapt to oxidative stress declines in senescent WI-38 cells and in our model ..
  25. Jefferson Y Chan; Fiscal Year: 2014
    ..Members of the CNC subfamily of basic-leucine zipper transcription factors including Nrf1 and Nrf2 have been implicated to mediate ARE ..
  26. Jefferson Y Chan; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Nrf1 and Nrf2 are members of the CNC family of bZIP transcription factors that exhibit structural similarities, and both are expressed in a wide range of tissues...
  27. Clinical Neuroscience Core Renovation for Psychology at University of New Mexico
    SUZANNE TRAGER ORTEGA; Fiscal Year: 2010
    ..9,363 square foot outdated neuroscience research space into a state-of-the-art Clinical Neuroscience Core (CNC) facility...
  28. Advanced Center to Improve Pediatric Mental Health Care (ACIPMHC)
    John Landsverk; Fiscal Year: 2012
    ..The Community Network Core (CNC) will strengthen a multiple sector infrastructure in San Diego County and link research activities to an emerging ..
  29. Uniform Naturalistic Teenage Driving Data Set
    ERIN ALLEN; Fiscal Year: 2013
    ..Specifically, novice teenage drivers have nearly four times the crash/near crash (CNC) rates and nearly five times higher rates of kinematic risky driving (e.g...
  30. RENE H GIFFORD; Fiscal Year: 2014
    ..g., CNC scores in quiet and the amount of residual hearing, with data that cannot be collected in the clinic, i.e...
  31. CNC HIV Anti-viral Therapy Effects Research (CHARTER) Extension
    Igor Grant; Fiscal Year: 2010
    ..abstract_text> ..
  32. CAUDAL NEUROPEPTIDES--NVIRONMENTAL REGULATION
    David Pearson; Fiscal Year: 1990
    ..to define the nature of neurosecretory products that are apparently induced in the caudal neurosecretory complex (CNC) of the normally marine fish, Gillichthys mirabillis, when it is acclimated to fresh water...
  33. Accessible Mounting and Positioning Technology
    DIANNE GOODWIN; Fiscal Year: 2006
    ..3D files are used to produce CNC-machined parts, and prototypes are assembled and tested to technical specifications...
  34. Regulation of paraxial mesoderm patterning
    ANDREW LASSAR; Fiscal Year: 2006
    ..and kinetics of head myogenesis are correlated with an inductive signal(s) secreted by the cranial neural crest (CNC), that both isolated CNC cells or medium conditioned by such cells can directly induce skeletal myogenesis in head ..
  35. ECAD:Enhanced Coronary Artery Disease Phantom for MRA
    Thomas Burke; Fiscal Year: 2006
    ..through the introduction of powerful computer based, finite element analysis and CAD/CAM integration with in house CNC prototype hardware. Process technology improvements will assist Phase Ill commercialization...
  36. ADAM FUNCTION IN NEURAL CREST CELLS
    Douglas DeSimone; Fiscal Year: 2006
    The cranial neural crest (CNC) is a population of cells formed at the border between the anterior neural and non-neural ectoderm in vertebrate embryos...
  37. STRUCTURE AND FUNCTION OF THE LCR-F1 GENE
    SUSAN FARMER; Fiscal Year: 1999
    ..Since LCR-F1 is a CNC domain family member, it may also be important in development...
  38. Molecular Regulatory Mechanism of Calvarial Morphogenesis
    Yang Chai; Fiscal Year: 2009
    ..in which CMC cells contribute to calvaria development and the molecular mechanism which regulates the fate of CNC are critical for understanding normal craniofacial development as well as CMC-related congenital malformations...
  39. NEUROPATHOLOGY AND BRAIN DEVELOPMENT IN PEDIATRIC AIDS
    Piotr Kozlowski; Fiscal Year: 1993
    ..on the immune system has been shown to produce a primary and persistent infection of the Central Nervous System (CNC) with relentlessly progressive encephalopathy...
  40. The Midwest Nursing Center Consortium Research Network
    Sally Lundeen; Fiscal Year: 2003
    ..around the establishment of: a) a regional PBRN of advanced practice nurse providers who practice in nontraditional CNC settings; this PBRN will link with other similar regional nursing PBRNs and grow to a national network over time; b)..
  41. Alk8/BMP Signals and Pharyngeal Arch Morphogenesis
    TRACIE FERREIRA; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Cranial Neural crest cells (CNC) are an embryonic population of multipotent precursor cells that give rise to craniofacial cartilage and bone in the head...
  42. GENETICS AND DEVELOPMENT OF THE SMALL MAF GENES
    JAMES ENGEL; Fiscal Year: 2003
    ..the original v-Maf oncoprotein fall into three categories, designated the large or small Maf family members and the CNC proteins...
  43. Nrf1 function by conditional knockout
    Jefferson Chan; Fiscal Year: 2003
    ..The CNC family of transcription factors consists of several closely related members (p45NFE2, Nrf1, Nrf2 and Nrf3) that ..
  44. A Drosophila model for the electrophile counter-attack chemoprevention strategy
    Dirk Bohmann; Fiscal Year: 2007
    ..Preliminary findings suggest that the Drosophila homologues of Nrf2 and Keap1 (CNC-C and dKeap1, respectively) comprise a cell protective module that responds to oxidants and to the chemopreventive ..
  45. ADAM Proteolytic and Adhesive Function in Cell Migration
    LANCE BRIDGES; Fiscal Year: 2006
    ..Several lines of evidence suggest that ADAMs may function in cell migration, such as in cranial neural crest (CNC) migration...
  46. TRANSDUCTION OF CHRONIC NERVE INJURY BY SCHWANN CELLS
    Ranjan Gupta; Fiscal Year: 2004
    ..Successful completion of these studies will provide a greater understanding of the pathogenesis of CNI so that more effective treatment modalities may be developed. ..
  47. COCHLEAR IMPLANT--AUDITORY FUNCTION & SPEECH PERCEPTION
    Michael Dorman; Fiscal Year: 2009
    ..abstract_text> ..
  48. ROLE OF THE CNC GENE IN DEVELOPMENT AND TUMORIGENESIS
    LAWRENCE KIRSCHNER; Fiscal Year: 2004
    DESCRIPTION (Adapted from applicant's description): Carney Complex (CNC) is an autosomal dominant tumor syndrome that is best classified as a novel form of multiple endocrine neoplasia. In this application, Dr. Lawrence S...
  49. Carney Complex: A Model for PKA-Mediated Tumorigenesis
    LAWRENCE KIRSCHNER; Fiscal Year: 2008
    ..research funded by an NIH K22 career development award, the investigator identified inactivating mutations in the PRKAR1A gene as responsible for the disease in approximately 50% of affected kindreds...
  50. Molecular and Metabolic Pathology of CNC-bZIP Knockouts
    Jefferson Chan; Fiscal Year: 2008
    Nrf1 and Nrf2 are members of the CNC family of bZIP transcription factors that exhibit structural similarities, and both are expressed in a wide range of tissues...
  51. FUNCTIONS OF A CONSERVED GERMLINE HELICASE IN C.ELEGANS
    Thomas Blackwell; Fiscal Year: 2005
    ..At the same time, they will elucidate post-transcriptional gene regulation mechanisms that may be of conserved importance during gametogenesis, and possibly for proliferation or survival of other stem cell types. ..
  52. Channel Interaction in Cochlear Implant Subjects
    JULIE BIERER; Fiscal Year: 2004
    ..The results of these studies could influence the development of future cochlear implant electrodes and speech processing strategies, ideally, leading to improved performance for most cochlear implant subjects. ..
  53. Nanoarray-Type Detection of Oct3/4 and Cdx2 using AuNPs and E-beam Patterns
    Jeong Yeol Yoon; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  54. Mutations in PKA gene transcripts of lupus T cells
    Dama Laxminarayana; Fiscal Year: 2007
    ..abstract_text> ..
  55. BENEFICIAL EFFECTS OF GINKGO BILOBA IN CANCER
    Vassilios Papadopoulos; Fiscal Year: 2002
    ..These experiments should demonstrate if EGB 761 could be used to prevent and/or stabilize the progression of cancer. ..
  56. MOLECULAR ANALYSIS OF TRISTETRAPROLIN FUNCTION
    Thomas Blackwell; Fiscal Year: 2005
    ..abstract_text> ..
  57. Plasma Diagnostic for Alzheimer's Disease Pathology
    Vassilios Papadopoulos; Fiscal Year: 2004
    ..In this Phase I application we propose to test this hypothesis in a small number of samples obtained from AD and control (non-demented) patients. ..
  58. MOLECULAR NEUROBIOLOGY OF DEPRESSION
    Richard Shelton; Fiscal Year: 2003
    ..Develop further expertise in basic molecular biological methods; 2. Develop new projects oriented to future funding opportunities; and 3. Continue to mentor the next generation of investigators. ..
  59. NEUREGULINS AND THE PATHOLOGY OF NERVE INJURY
    Steven Carroll; Fiscal Year: 2002
    ....
  60. Acoustic and electrical hearing after Atoh1 treatment
    Bryan E Pfingst; Fiscal Year: 2010
    ....
  61. NUCLEUS ACCUMBENS INVOLVEMENT IN COCAINE REINFORCEMENT
    GREGORY MARK; Fiscal Year: 2002
    ..It is hoped that these results will further our understanding of the involvement of cholinergic mechanisms in drug-seeking and potentially to the development of clinically efficacious treatments for drug craving and relapse. ..
  62. FEATURES OF STIMULATION IMPORTANT FOR ELECTRICAL HEARING
    BRYAN PFINGST; Fiscal Year: 2003
    ..abstract_text> ..
  63. HOMOCYSTEINE AND CONGENITAL HEART DEFECTS
    Thomas Rosenquist; Fiscal Year: 2003
    ..abstract_text> ..
  64. Longitudinal Narrative Study of Women Who were Unsuccessful in Work-based Welfare
    Eugenie Hildebrandt; Fiscal Year: 2009
    ..Each woman will be interviewed four times over a 12-month period. The primary analytic approach will be a multistage narrative analysis developed by the investigative team for application in longitudinal qualitative interview studies. ..
  65. Endocrine pancreatic cell regeneration from bone marrow
    Mehboob A Hussain; Fiscal Year: 2010
    ..4) To identify the cell type within BM that contributes to the pancreatic endocrine cell population. The long-term goal of these studies is to evaluate transplantation of BM derived cells as a potential treatment for diabetes mellitus. ..
  66. Central Cholinergic Involvement in Cocaine Addiction
    GREGORY MARK; Fiscal Year: 2007
    ..abstract_text> ..
  67. Characterization of the "Gs-like" activity of Xlas
    Murat Bastepe; Fiscal Year: 2005
    ..These studies will be helpful in clarifying the biological roles of XLalphas, and may furthermore improve the current understanding of the GNASl-related disorders. ..
  68. FUNCTIONAL EFFECTS OF DEAFNESS AND NEURAL STIMULATION
    BRYAN PFINGST; Fiscal Year: 2005
    ....
  69. Role of Neuregulin-1 in Schwann Cell Neoplasia
    Steven Carroll; Fiscal Year: 2008
    ..These studies will provide important insights into the mechanisms promoting MPNST formation and establish the NRG-1/erbB signaling pathway as a novel therapeutic target in MPNSTs. [unreadable] [unreadable]..

Patents1

  1. COMPLENTARY DNA PROBES FOR HUMAN REGULATORY SUBUNITS (RI alpha AND RII beta) OF cAMP-DEPENDENT PROTEIN KINASES
    Patent Number: WO8803164-A1; Date:1988-05-05