pregnancy associated plasma protein A

Summary

Gene Symbol: pregnancy associated plasma protein A
Description: pappalysin 1
Alias: ASBABP2, DIPLA1, IGFBP-4ase, PAPA, PAPP-A, PAPPA1, pappalysin-1, IGF-dependent IGFBP-4 protease, aspecific BCL2 ARE-binding protein 2, differentially placenta 1 expressed protein, insulin-like growth factor-dependent IGF binding protein-4 protease, pregnacy-associated plasma protein A, pregnancy-associated plasma protein A, pappalysin 1
Species: human

Top Publications

  1. ncbi Immunohistochemical demonstration of pregnancy-associated plasma protein A (PAPP-A) in the syncytiotrophoblast of the normal placenta at different gestational ages
    D Tornehave
    Placenta 5:427-31. 1984
  2. ncbi Amino acid sequence of human pregnancy-associated plasma protein-A derived from cloned cDNA
    T Kristensen
    Department of Chemistry, Aarhus University, Denmark
    Biochemistry 33:1592-8. 1994
  3. ncbi Localization of pregnancy-associated plasma protein-A and colocalization of pregnancy-associated plasma protein-A messenger ribonucleic acid and eosinophil granule major basic protein messenger ribonucleic acid in placenta
    M Bonno
    Department of Immunology, Mayo Clinic, Rochester, Minnesota
    Lab Invest 71:560-6. 1994
  4. ncbi Circulating human pregnancy-associated plasma protein-A is disulfide-bridged to the proform of eosinophil major basic protein
    C Oxvig
    Department of Molecular Biology, University of Aarhus, Denmark
    J Biol Chem 268:12243-6. 1993
  5. pmc The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A
    J B Lawrence
    Endocrine Research Unit, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Proc Natl Acad Sci U S A 96:3149-53. 1999
  6. ncbi Messenger ribonucleic acid levels of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein: expression in human reproductive and nonreproductive tissues
    M T Overgaard
    Department of Molecular and Structural Biology, University of Aarhus, 8000 Aarhus C, Denmark
    Biol Reprod 61:1083-9. 1999
  7. ncbi Expression of recombinant human pregnancy-associated plasma protein-A and identification of the proform of eosinophil major basic protein as its physiological inhibitor
    M T Overgaard
    Department of Molecular and Structural Biology, Science Park, University of Aarhus, Gustav Wieds Vej 10C, DK 8000 Aarhus C, Denmark
    J Biol Chem 275:31128-33. 2000
  8. ncbi Pregnancy-associated plasma protein-A (PAPP-A) cleaves insulin-like growth factor binding protein (IGFBP)-5 independent of IGF: implications for the mechanism of IGFBP-4 proteolysis by PAPP-A
    L S Laursen
    Department of Molecular and Structural Biology, University of Aarhus, Science Park, Denmark
    FEBS Lett 504:36-40. 2001
  9. ncbi Cell surface targeting of pregnancy-associated plasma protein A proteolytic activity. Reversible adhesion is mediated by two neighboring short consensus repeats
    Lisbeth S Laursen
    Department of Molecular Biology, Science Park, University of Aarhus, Aarhus C, Denmark
    J Biol Chem 277:47225-34. 2002
  10. ncbi Serum plasma pregnancy-associated protein A: a potential marker of echogenic carotid atherosclerotic plaques in asymptomatic hyperlipidemic subjects at high cardiovascular risk
    Jean Louis Beaudeux
    Department of Clinical Biochemistry, the National Institute for Health, Paris, France
    Arterioscler Thromb Vasc Biol 23:e7-10. 2003

Research Grants

  1. Role of PAPP-A in Atherosclerosis
    Cheryl A Conover; Fiscal Year: 2012
  2. Poor nutrition and fetal development: preadipocyte adaptation in a primate model
    YOURKA DIMOVA TCHOUKALOVA; Fiscal Year: 2010
  3. Cheryl A Conover; Fiscal Year: 2016
  4. THE PHYSIOLOGY OF IGFBP DEGRADING PROTEINASES IN BONE
    John Fowlkes; Fiscal Year: 2009
  5. Identification of Alternative Substrates of Pregnancy-Associated Plasma Protein-A
    James Lawrence; Fiscal Year: 2008
  6. MECHANISMS OF ACTIVATION OF ICE-LIKE CYSTEINE PROTEASES
    Emad S Alnemri; Fiscal Year: 2012
  7. Emad S Alnemri; Fiscal Year: 2016
  8. Todd B Reynolds; Fiscal Year: 2015
  9. Role of PSTPIP1 in a Mouse Model of PAPA Syndrome
    Donghai Wang; Fiscal Year: 2012
  10. Methane Monoxygenase Structure and Function
    John Lipscomb; Fiscal Year: 2009

Detail Information

Publications228 found, 100 shown here

  1. ncbi Immunohistochemical demonstration of pregnancy-associated plasma protein A (PAPP-A) in the syncytiotrophoblast of the normal placenta at different gestational ages
    D Tornehave
    Placenta 5:427-31. 1984
    ..The results indicate that PAPP-A is probably synthesized in the syncytiotrophoblast...
  2. ncbi Amino acid sequence of human pregnancy-associated plasma protein-A derived from cloned cDNA
    T Kristensen
    Department of Chemistry, Aarhus University, Denmark
    Biochemistry 33:1592-8. 1994
    ..Apart from these features, the PAPP-A sequence is not related to other known protein sequences...
  3. ncbi Localization of pregnancy-associated plasma protein-A and colocalization of pregnancy-associated plasma protein-A messenger ribonucleic acid and eosinophil granule major basic protein messenger ribonucleic acid in placenta
    M Bonno
    Department of Immunology, Mayo Clinic, Rochester, Minnesota
    Lab Invest 71:560-6. 1994
    ..In addition, the PAPP-A subunit nucleotide and deduced amino acid sequence have been determined from cloned cDNA. The PAPP-A monomer found in plasma contains 1547 amino acid residues...
  4. ncbi Circulating human pregnancy-associated plasma protein-A is disulfide-bridged to the proform of eosinophil major basic protein
    C Oxvig
    Department of Molecular Biology, University of Aarhus, Denmark
    J Biol Chem 268:12243-6. 1993
    ..In addition, it is shown that commercial polyclonal anti-PAPP-A is polyspecific, also reacting with MBP...
  5. pmc The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A
    J B Lawrence
    Endocrine Research Unit, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Proc Natl Acad Sci U S A 96:3149-53. 1999
    ..In conclusion, we have identified an IGF-dependent IGFBP protease and at the same time assigned a function to PAPP-A. This represents an unanticipated union of two areas of research that were not linked in any way before this report...
  6. ncbi Messenger ribonucleic acid levels of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein: expression in human reproductive and nonreproductive tissues
    M T Overgaard
    Department of Molecular and Structural Biology, University of Aarhus, 8000 Aarhus C, Denmark
    Biol Reprod 61:1083-9. 1999
    ..Both mRNA species were significantly more abundant in term placenta than in other tissues analyzed. All analyzed tissues, including endometrium, myometrium, colon, and kidney, contained both PAPP-A and proMBP mRNA...
  7. ncbi Expression of recombinant human pregnancy-associated plasma protein-A and identification of the proform of eosinophil major basic protein as its physiological inhibitor
    M T Overgaard
    Department of Molecular and Structural Biology, Science Park, University of Aarhus, Gustav Wieds Vej 10C, DK 8000 Aarhus C, Denmark
    J Biol Chem 275:31128-33. 2000
    ..Inhibition of PAPP-A by proMBP represents a novel inhibitory mechanism with the enzyme irreversibly bound to its inhibitor by disulfide bonds...
  8. ncbi Pregnancy-associated plasma protein-A (PAPP-A) cleaves insulin-like growth factor binding protein (IGFBP)-5 independent of IGF: implications for the mechanism of IGFBP-4 proteolysis by PAPP-A
    L S Laursen
    Department of Molecular and Structural Biology, University of Aarhus, Science Park, Denmark
    FEBS Lett 504:36-40. 2001
    ..We thus conclude that IGF enhances proteolysis by binding to IGFBP-4, not by interaction with PAPP-A, which could not previously be ruled out...
  9. ncbi Cell surface targeting of pregnancy-associated plasma protein A proteolytic activity. Reversible adhesion is mediated by two neighboring short consensus repeats
    Lisbeth S Laursen
    Department of Molecular Biology, Science Park, University of Aarhus, Aarhus C, Denmark
    J Biol Chem 277:47225-34. 2002
    ..proMBP restores surface binding. We finally propose a model in which IGF bioactivity is regulated by reversible cell surface binding of PAPP-A, which in turn is regulated by proMBP...
  10. ncbi Serum plasma pregnancy-associated protein A: a potential marker of echogenic carotid atherosclerotic plaques in asymptomatic hyperlipidemic subjects at high cardiovascular risk
    Jean Louis Beaudeux
    Department of Clinical Biochemistry, the National Institute for Health, Paris, France
    Arterioscler Thromb Vasc Biol 23:e7-10. 2003
    ..We evaluated serum PAPP-A levels as a marker of the premature development of atherosclerosis in hyperlipidemic subjects at elevated cardiovascular risk...
  11. ncbi Expression of pregnancy-associated plasma protein-A (PAPP-A) during human villous trophoblast differentiation in vitro
    J Guibourdenche
    Unite INSERM U427, Faculte des Sciences Pharmaceutiques et Biologiques, 4 avenue de I Observatoire, 75270 Paris, France
    Placenta 24:532-9. 2003
    ..In conclusion, PAPP-A production in vitro, is associated to the differentiation of villous cytotrophoblast cells into syncytiotrophoblast, independently of the age of gestation...
  12. ncbi Transforming growth factor-beta regulation of the insulin-like growth factor binding protein-4 protease system in cultured human osteoblasts
    Christopher O Ortiz
    Division of Endocrinology and Metabolism, Endocrine Research Unit, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 5590, USA
    J Bone Miner Res 18:1066-72. 2003
    ..These data support a model whereby local TGF-beta and IGF-II in the bone microenvironment coordinately amplify IGF-I bioavailability through controlled IGFBP-4 proteolysis, which may be a means to promote bone formation...
  13. ncbi Localization and regulation of pregnancy-associated plasma protein a expression in healing human skin
    Bing Kun Chen
    Endocrine Research Unit, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 88:4465-71. 2003
    ..These data demonstrate localized and regulated expression of PAPP-A in human skin and suggest that PAPP-A may play an important role in an integrated IGF system in wound healing and tissue remodeling in vivo...
  14. ncbi Circulating pregnancy-associated plasma protein a predicts outcome in patients with acute coronary syndrome but no troponin I elevation
    Juha Lund
    Department of Medicine, University and Turku University Central Hospital, POB 52, FIN 20520 Turku, Finland
    Circulation 108:1924-6. 2003
    ..We investigated the predictive value of circulating pregnancy-associated plasma protein A (PAPP-A), a novel marker of atherosclerotic plaque activity, in these patients...
  15. ncbi Pregnancy-associated plasma protein-A (PAPP-A) expression and insulin-like growth factor binding protein-4 protease activity in normal and malignant ovarian surface epithelial cells
    Kimberly R Kalli
    Division of Endocrinology, Metabolism and Nutrition, Endocrine Research Unit, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Int J Cancer 110:633-40. 2004
    ..The concurrent regulation of PAPP-A and its inhibitor, proMBP, suggests that IGFBP-4 proteolysis and local regulation of IGF availability may be altered in malignant ovarian epithelial cells...
  16. pmc Pregnancy-associated plasma protein-A regulates myoblast proliferation and differentiation through an insulin-like growth factor-dependent mechanism
    Ashok Kumar
    Musculoskeletal Disease Center, JL Pettis Memorial Veterans Affairs Medical Center, CA 92357, USA
    J Biol Chem 280:37782-9. 2005
    ....
  17. ncbi Modulation of PAPP-A expression by PPARgamma in human first trimester trophoblast
    K Handschuh
    INSERM U427, Faculte de Pharmacie, 4 avenue de l Observatoire, 75006 Paris, France
    Placenta 27:S127-34. 2006
    ..Since we have previously shown that PPARgamma agonist inhibits EVCT invasion in vitro, we suggest that PPARgamma-mediated inhibition of PAPP-A might decrease the amount of bioactive IGFII, a factor known to promote trophoblast invasion...
  18. ncbi Cell surface detachment of pregnancy-associated plasma protein-A requires the formation of intermolecular proteinase-inhibitor disulfide bonds and glycosaminoglycan covalently bound to the inhibitor
    Simon Glerup
    Department of Molecular Biology, University of Aarhus, Gustav Wieds Vej 10C, DK 8000 Aarhus C, Denmark
    J Biol Chem 282:1769-78. 2007
    ..Because both PAPP-A and proMBP are expressed ubiquitously, this model may be applicable to many tissues in which insulin-like growth factor bioavailability is locally regulated...
  19. ncbi Pregnancy-associated plasma protein A and proform eosinophilic major basic protein in the detection of different types of coronary artery disease
    P Hajek
    Department of Cardiology, Second Medical School and University Hospital of Charles University Prague, CzechRepublic
    Physiol Res 57:23-32. 2008
    ..75 mIU/l. Combination of PAPP-A/proMBP with cTnI increases their diagnostic efficacy within the early phase of ACS. Our results suggest that PAPP-A/proMBP complex is involved in processes preceding vulnerable plaque development in ACS...
  20. ncbi Pregnancy-associated plasma protein a and soluble receptor for advanced glycation end products after kidney transplantation
    Marta Kalousova
    Institute of Clinical Chemistry and Laboratory Diagnostics, First Faculty of Medicine and General University Hospital, Charles University, Prague, Czech Republic
    Kidney Blood Press Res 30:31-7. 2007
    ..Pregnancy-associated plasma protein A (PAPP-A) and soluble receptor for advanced glycation end products (sRAGE) are new markers related to vascular damage...
  21. doi Inhibition of the proteolytic activity of pregnancy-associated plasma protein-A by targeting substrate exosite binding
    Jakob H Mikkelsen
    Department of Molecular Biology, University of Aarhus, DK 8000 Aarhus, Denmark
    J Biol Chem 283:16772-80. 2008
    ....
  22. doi Pregnancy-associated plasma protein-A (PAPP-A) and cardiovascular risk
    Luciano Consuegra-Sanchez
    Cardiovascular Biology Research Centre, St George s, University of London, Cranmer Terrace, UK
    Atherosclerosis 203:346-52. 2009
    ..The present article reviews currently available evidence supporting a role for PAPP-A as a marker of cardiovascular risk and discusses some of the pitfalls that may limit its use in clinical practice...
  23. doi Relationship between pregnancy-associated plasma protein-A and lung cancer
    Ismet Bulut
    Department of Chest Disease and Tuberculosis and Internal Medicine, School of Medicine, Dumlupinar University, Kutahya, Turkey
    Am J Med Sci 337:241-4. 2009
    ..We postulated that PAPP-A may contribute to the availability and activity of IGFs, which affect lung cancer. Therefore, we determined the levels of PAPP-A in patients with lung cancer and their possible clinical significance...
  24. doi First trimester PAPP-A levels associated with early prediction of pregnancy induced hypertension
    Paolo Meloni
    Department of General Surgery Pietro Valdoni, Policlinico Umberto I, La Sapienza University, Rome, Italy
    Hypertens Pregnancy 28:361-8. 2009
    ..The purpose of this study was to determine the predictive value of maternal PAPP-A levels in the identification of women at risk of PIH...
  25. doi Pregnancy-associated plasma protein-A, a marker for outcome in patients suspected for acute coronary syndrome
    Kasper K Iversen
    Department of Cardiology, Hillerod Hospital, Hillerod, Denmark
    Clin Biochem 43:851-7. 2010
    ..To examine if pregnancy-associated plasma protein-A (PAPP-A) in patients with chest pain, could identify patients at risk for death or myocardial infarction...
  26. pmc First-trimester serum analytes, biophysical tests and the association with pathological morphometry in the placenta of pregnancies with preeclampsia and fetal growth restriction
    A O Odibo
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine and Ultrasound, Washington University, St Louis, MO 63110, USA
    Placenta 32:333-8. 2011
    ....
  27. doi The secretion of PAPP-A, ADAM12, and PP13 correlates with the size of the placenta for the first month of pregnancy
    M Sahraravand
    Department of Obstetrics and Gynecology, Oulu University Hospital, PO Box 5000, FIN 90014 Oulu, Finland
    Placenta 32:999-1003. 2011
    ..The aim of the study was to assess the connection between the secretion of these proteins and the growth of the gestational sac and the placenta...
  28. doi Pregnancy-associated plasma protein A as an independent mortality predictor in long-term hemodialysis patients
    Marta Kalousova
    Institute of Clinical Biochemistry and Laboratory Diagnostics, Charles University and General University Hospital, Prague, Czech Republic
    Kidney Blood Press Res 35:192-201. 2012
    ..Pregnancy-associated plasma protein A (PAPP-A) is a biomarker related to vascular damage. The aim of the study was to focus on PAPP-A and related parameters and their relationship to the prognosis of long-term hemodialysis (HD) patients...
  29. doi Homodimeric pregnancy-associated plasma protein-A in normal human placenta of first and third trimester of pregnancy: biochemical and morphological observations
    P D'Elia
    Laboratory of Biochemistry of Sexual Hormones, Department of Gynaecology, Obstetrics and Urology, University La Sapienza, Viale Regina Elena 328, 00161, Roma, Italy
    Placenta 33:942-5. 2012
    ..In agreement with the above, dPAPP-A is released only by first trimester placental explants in culture...
  30. ncbi Obstetrical complications associated with abnormal maternal serum markers analytes
    Alain Gagnon
    Vancouver BC
    J Obstet Gynaecol Can 30:918-49. 2008
    ..To provide guidance to facilitate the management of pregnancies that have abnormal levels of one of more markers and to assess the usefulness of these markers as a screening test...
  31. ncbi Insulin-like growth factor binding protein 4 expression parallels luteinizing hormone receptor expression and follicular luteinization in the primate ovary
    Jian Zhou
    Developmental Endocrinology Branch, NICHD, NIH, Bethesda, Maryland 20892, USA
    Biol Reprod 69:22-9. 2003
    ..These observations suggest that IGFBP4 or an IGFBP4 proteolytic product may be involved with LH-induced steroidogenesis and/or luteinization rather than with inhibition of follicular growth...
  32. ncbi First- and second-trimester evaluation of risk for Down syndrome
    Robert H Ball
    Department of Obstetrics, Gynecology, and Reproductive Sciences, UCSF, San Francisco, CA 94143 0132, USA
    Obstet Gynecol 110:10-7. 2007
    ..To investigate the differences in costs and outcomes of Down syndrome screening using data from the First and Second Trimester Evaluation of Risk (FASTER) Trial...
  33. doi Fetal nasal bone in screening for trisomies 21, 18 and 13 and Turner syndrome at 11-13 weeks of gestation
    K O Kagan
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, UK
    Ultrasound Obstet Gynecol 33:259-64. 2009
    ....
  34. ncbi Total pregnancy-associated plasma protein A--a first trimester maternal serum marker for Down's syndrome: clinical and technical assessment of a poly-monoclonal enzyme immunoassay
    M Christiansen
    Department of Clinical Biochemistry, Statens Serum Institut, Copenhagen, Denmark
    Scand J Clin Lab Invest 63:407-15. 2003
    ..Together with beta-HCG and nuchal translucency, two other first trimester markers for fetal DS, a DR 90% could be obtained for an SPR of 5%...
  35. doi Screening for trisomy 21 by maternal age, fetal nuchal translucency thickness, free beta-human chorionic gonadotropin and pregnancy-associated plasma protein-A
    K O Kagan
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, UK
    Ultrasound Obstet Gynecol 31:618-24. 2008
    ....
  36. doi Screening for trisomies 21, 18 and 13 by maternal age, fetal nuchal translucency, fetal heart rate, free beta-hCG and pregnancy-associated plasma protein-A
    Karl O Kagan
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, Denmark Hill, London SE5 8RX, UK
    Hum Reprod 23:1968-75. 2008
    ....
  37. ncbi Pregnancy-associated plasma protein-A polymorphism and the risk of recurrent pregnancy loss
    Kana Suzuki
    Department of Public Heath, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    J Reprod Immunol 70:99-108. 2006
    ..83; 95% CI, 1.00-8.05; AC+CC genotypes: OR, 1.65; CI, 1.04-2.62). This is the first report on the PAPPA gene polymorphism in women with RPL, demonstrating some association between the investigated polymorphism and the risk of RPL...
  38. pmc Transforming growth factor-beta1 modulates insulin-like growth factor binding protein-4 expression and proteolysis in cultured periosteal explants
    Carlos Gonzalez
    Cartilage and Connective Tissue Research Laboratory, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Growth Horm IGF Res 20:81-6. 2010
    ..The purpose of this study was to determine the effect of TGF-beta1 on IGF binding protein-4 (IGFBP-4) and the IGFBP-4 protease pregnancy-associated plasma protein-A (PAPP-A) expression in cultured periosteal explants...
  39. doi Frontomaxillary facial angle in screening for trisomy 21 at 11 + 0 to 13 + 6 weeks
    M Borenstein
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, UK
    Ultrasound Obstet Gynecol 32:5-11. 2008
    ....
  40. ncbi Identification and regulation of the IGFBP-4 protease and its physiological inhibitor in human trophoblasts and endometrial stroma: evidence for paracrine regulation of IGF-II bioavailability in the placental bed during human implantation
    L C Giudice
    Department of Gynecology and Obstetrics, Stanford University Medical Center, Stanford, California 94305, USA
    J Clin Endocrinol Metab 87:2359-66. 2002
    ..Overall, the data underscore potential roles for a complex family of enzyme (PAPP-A), substrate (IGFBP-4), inhibitor (proMBP), and cofactor (IGF-II) in the placental bed during human implantation...
  41. ncbi Uptake of prenatal screening for chromosomal anomalies: impact of test results in a previous pregnancy
    Kevin Spencer
    Prenatal Screening Unit, Clinical Biochemistry Dept, Harold Wood Hospital, Gubbins Lane, Romford, RM3 0BE, UK
    Prenat Diagn 22:1229-32. 2002
    ..To assess whether the uptake of prenatal screening for trisomy 21 in a subsequent pregnancy is influenced by being classified in the 'increased risk' or 'not at increased risk' group in the first pregnancy...
  42. doi Screening for trisomy 18 by maternal age, fetal nuchal translucency, free beta-human chorionic gonadotropin and pregnancy-associated plasma protein-A
    K O Kagan
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, UK
    Ultrasound Obstet Gynecol 32:488-92. 2008
    ....
  43. ncbi Prediction of pre-eclampsia by uterine artery Doppler ultrasonography and maternal serum pregnancy-associated plasma protein-A, free beta-human chorionic gonadotropin, activin A and inhibin A at 22 + 0 to 24 + 6 weeks' gestation
    K Spencer
    Prenatal Screening Unit, Clinical Biochemistry Department, Harold Wood Hospital, Romford, UK
    Ultrasound Obstet Gynecol 27:658-63. 2006
    ....
  44. ncbi Additional performance of nasal bone in first trimester screening
    P Kozlowski
    Praenatal Medizin und Genetik Dusseldorf, 40210 Düsseldorf, Germany
    Ultraschall Med 27:336-9. 2006
    ....
  45. ncbi Quantitative analysis of insulin-like growth factor-modulated proteolysis of insulin-like growth factor binding protein-4 and -5 by pregnancy-associated plasma protein-A
    Claus Gyrup
    Department of Molecular Biology, University of Aarhus, Gustav Wieds Vej 10C, DK 8000 Aarhus C, Denmark
    Biochemistry 46:1972-80. 2007
    ..Finally, we have compared PAPP-A to other proteinases thought to have IGFBP-4 or -5 as a substrate. This emphasizes the potential of PAPP-A to specifically and efficiently function as a regulator in the IGF system...
  46. ncbi Maternal serum free-beta-chorionic gonadotrophin, pregnancy-associated plasma protein-A and fetal nuchal translucency thickness at 10-13(+6) weeks in relation to co-variables in pregnant Saudi women
    Mohammed Salleh M Ardawi
    Department of Clinical Biochemistry, Faculty of Medicine and King Abdulaziz University Hospital, King Abdulaziz University, Jeddah, Saudi Arabia
    Prenat Diagn 27:303-11. 2007
    ....
  47. doi Does pregnancy-associated plasma protein A have a role in allergic rhinitis?
    Ender Guclu
    Department of Otolaryngology, Duzce University School of Medicine, Duzce, Turkey
    Am J Rhinol 22:219-22. 2008
    ..PAPP-A also is produced in high concentrations by trophoblasts during pregnancy...
  48. ncbi Pregnancy-associated plasma protein-A (PAPP-A): a local regulator of IGF bioavailability through cleavage of IGFBPs
    Henning B Boldt
    Division of Endocrinology, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic College of Medicine, 200 First Street SW, 5 194 Joseph, Rochester, MN 55905, USA
    Growth Horm IGF Res 17:10-8. 2007
    ....
  49. ncbi First-trimester ultrasound and biochemical markers of aneuploidy and the prediction of impending fetal death
    K Spencer
    Prenatal Screening Unit, Clinical Biochemistry Department, Harold Wood Hospital, Romford, Essex, UK
    Ultrasound Obstet Gynecol 28:637-43. 2006
    ..To examine the clinical utility of the first-trimester markers of aneuploidy in their ability to predict future fetal loss...
  50. ncbi Association of extreme first-trimester free human chorionic gonadotropin-beta, pregnancy-associated plasma protein A, and nuchal translucency with intrauterine growth restriction and other adverse pregnancy outcomes
    David Krantz
    NTD Laboratories Inc, 403 Oakwood Road, Huntington Station, NY 11746, USA
    Am J Obstet Gynecol 191:1452-8. 2004
    ....
  51. ncbi First trimester maternal serum screening for Down's syndrome: an evaluation of the DPC Immulite 2000 free beta-hCG and pregnancy-associated plasma protein-A assays
    Kevin Spencer
    Prenatal Screening Unit, Clinical Biochemistry Department, Harold Wood Hospital, Gubbins Lane, Romford, Essex, UK
    Ann Clin Biochem 42:30-40. 2005
    ..With the recent launch of these assays on the DPC Immulite 2000 platform, it is appropriate and timely to investigate their clinical and analytical performance on a high throughput immunoassay analyser...
  52. ncbi Ethnicity and the need for correction of biochemical and ultrasound markers of chromosomal anomalies in the first trimester: a study of Oriental, Asian and Afro-Caribbean populations
    K Spencer
    Prenatal Screening Unit, Clinical Biochemistry Department, Harold Wood Hospital, Essex, UK
    Prenat Diagn 25:365-9. 2005
    ....
  53. doi First trimester predictors of adverse pregnancy outcomes
    Kate J Brameld
    Office of Population Health Genomics, Department of Health, East Perth, Western Australia, Australia
    Aust N Z J Obstet Gynaecol 48:529-35. 2008
    ..To identify first trimester indicators of adverse pregnancy outcomes...
  54. ncbi Point-of-care time-resolved immunofluorometric assay for human pregnancy-associated plasma protein A: use in first-trimester screening for Down syndrome
    Qiu Ping Qin
    Department of Biotechnology, University of Turku, Tykistokatu 6, 20520 Turku, Finland
    Clin Chem 48:473-83. 2002
    ..We aimed to develop a fast point-of-care assay that could be placed in one-stop clinics for the measurement of PAPP-A...
  55. ncbi First-trimester ultrasound and biochemical markers of aneuploidy and the prediction of preterm or early preterm delivery
    K Spencer
    Prenatal Screening Unit, Clinical Biochemistry Department, Harold Wood Hospital, Romford, Essex, UK
    Ultrasound Obstet Gynecol 31:147-52. 2008
    ..To examine the clinical utility of the first-trimester markers of aneuploidy in their ability to predict preterm delivery...
  56. doi A new approach to calculating the risk of chromosomal abnormalities with first-trimester screening data
    E Merz
    Department of Obstetrics and Gynecology Hospital Nordwest, Frankfurt Main, Germany
    Ultraschall Med 29:639-45. 2008
    ..The aim of this project was to develop a CE-certified new risk calculation program (PRC = Prenatal Risk Calculation) using a nationwide database...
  57. ncbi [Evaluation of pregnancy-associated plasma protein A (PAPP-A) and free beta subunit of human chorionic gonadotropin (beta hCG) levels and sonographic assesement of fetal nuchal translucency (NT) in singleton pregnancies between 11 and 14 weeks of gestatio
    Dariusz Borowski
    Klinika Terapii Płodu ICZMP w łodzi
    Ginekol Pol 78:384-7. 2007
    ....
  58. ncbi First-trimester maternal serum PP-13, PAPP-A and second-trimester uterine artery Doppler pulsatility index as markers of pre-eclampsia
    K Spencer
    Department of Clinical Biochemistry, Harold Wood Hospital, Romford, UK
    Ultrasound Obstet Gynecol 29:128-34. 2007
    ..plasma protein-A (PAPP-A) at 11 + 0 to 13 + 6 weeks of gestation alone or in combination with second-trimester uterine artery pulsitility measured by Doppler velocimetry is useful in predicting those women who will develop pre-eclampsia..
  59. ncbi Repeated measurement of pregnancy-associated plasma protein-A (PAPP-A) in Down syndrome screening: a validation study
    Glenn E Palomaki
    Women and Infants Hospital, Providence, Rhode Island 02903, USA
    Prenat Diagn 26:730-9. 2006
    ..To confirm that measuring pregnancy-associated plasma protein-A (PAPP-A) in both first- and second-trimester serum samples improves Down syndrome screening...
  60. ncbi [Noninvasive prenatal test in the first trimester of pregnancy (NT and estimation of beta-hCG and PAPP-A) in the diagnosis of fetal abnormalities in Polish population--comparison of the biochemistry own normal ranges and literature reported data]
    Sofija Mandryka-Stankewycz
    Klinika Medycyny Ptodu i Ginekologii I Katedry Ginekologii i Połoznictwa Uniwersytetu Medycznego w Łodzi
    Ginekol Pol 80:851-5. 2009
    ..Estimation the sensitivity of the fetal nuchal translucency measurement, biochemical concentrations of PAPP-A and free beta-HCG in detection of the fetal chromosomal abnormalities...
  61. doi Screening for adverse pregnancy outcome by ductus venosus Doppler at 11-13+6 weeks of gestation
    Nerea Maiz
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, United Kingdom
    Obstet Gynecol 112:598-605. 2008
    ..To estimate the independent contribution of abnormal flow in the ductus venosus at 11 to 13+6 weeks of gestation in the prediction of major fetal abnormalities and fetal death...
  62. doi The impact of assisted reproductive technology on the association between first-trimester pregnancy-associated plasma protein a and human chorionic gonadotropin and adverse pregnancy outcomes
    Yan Zhong
    Division of Maternal Fetal Medicine, Ultrasound and Genetics, Department of Obstetrics and Gynecology, Washington University, St Louis, MO 63110, USA
    Am J Perinatol 28:347-54. 2011
    ..6, 95% CI 1.0, 2.5) and PTD < 37 weeks (OR = 1.4, 95% CI 1.0, 1.9) in non-ART pregnancies. The association between PAPP-A and β-hCG with adverse pregnancy outcomes is influenced by the mode of conception...
  63. ncbi Pregnancy-associated plasma protein-A is involved in insulin-like growth factor binding protein-2 (IGFBP-2) proteolytic degradation in bovine and porcine preovulatory follicles: identification of cleavage site and characterization of IGFBP-2 degradation
    Philippe Monget
    INRA, UMR Physiologie de la Reproduction et des Comportements 6073, INRA CNRS Université, 37380 Nouzilly, France
    Biol Reprod 68:77-86. 2003
    ....
  64. ncbi Pregnancy-associated plasma protein-A2 (PAPP-A2), a novel insulin-like growth factor-binding protein-5 proteinase
    M T Overgaard
    Department of Molecular and Structural Biology, Science Park, University of Aarhus, Gustav Wieds Vej 10C, DK 8000 Aarhus C, Denmark
    J Biol Chem 276:21849-53. 2001
    ..Because of its close relationship with PAPP-A, both structurally and functionally, PAPP-A2 is a likely candidate IGFBP-5 proteinase in many tissues and conditioned media where IGFBP-5 proteolysis has been reported...
  65. ncbi Pregnancy-associated plasma protein-A and insulin-like growth factor binding protein mRNAs in granulosa cells of dominant and subordinate follicles of preovulatory cattle
    Consuelo A Santiago
    Department of Animal Science, Oklahoma State University, Stillwater, OK 74078, USA
    Domest Anim Endocrinol 28:46-63. 2005
    ....
  66. ncbi [PAPP-A in the first trimester of pregnancy]
    L Fialova
    1 ústav lékarské chemie a biochemie 1 LF UK, Praha
    Ceska Gynekol 66:280-5. 2001
    ....
  67. ncbi Localization and cellular distribution of pregnancy-associated plasma protein-a and major basic protein in human ovary and corpora lutea throughout the menstrual cycle
    Alice Rhoton-Vlasak
    Department of Obstetrics and Gynecology, University of Florida, Gainesville, Florida 32610, USA
    Fertil Steril 79:1149-53. 2003
    ..To assess the expression and cellular distribution of pregnancy-associated plasma protein-A (PAPP-A) and major basic protein (MBP) in human ovarian tissue during the menstrual cycle...
  68. ncbi The first trimester 'combined test' for the detection of Down syndrome pregnancies in 4939 unselected pregnancies
    K Schuchter
    Ludwig Boltzmann Institute for Clinical Gynaecology and Obstetrics, Donauspital am SMZO, Vienna, Austria
    Prenat Diagn 22:211-5. 2002
    ..The DR for DS can be increased much more markedly using the 'combined test' with a FPR that still remains at the level as it was in the early 1970s...
  69. ncbi Screening for trisomy 21 in twin pregnancies in the first trimester using free beta-hCG and PAPP-A, combined with fetal nuchal translucency thickness
    K Spencer
    Endocrine Unit, Clinical Biochemistry Department, Harold Wood Hospital, Gubbins Lane, Romford, Essex RM3 0BE, UK
    Prenat Diagn 20:91-5. 2000
    ..Twin screening using both modalities should be considered when introducing first trimester screening...
  70. ncbi First trimester screening with free beta-hCG, PAPP-A and nuchal translucency in pregnancies conceived with assisted reproduction
    Francesco Orlandi
    Centro di Diagnosi Prenatale, Palermo, Italy
    Prenat Diagn 22:718-21. 2002
    ..To evaluate the effect of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) on free beta-human chorionic gonadotrophin (beta-hCG), pregnancy-associated plasma protein A (PAPP-A) and nuchal translucency (NT)...
  71. ncbi Maternal weight and ethnic adjustment within a first-trimester Down syndrome and trisomy 18 screening program
    David A Krantz
    Research Division, NTD Laboratories, Huntington Station, New York 11746, USA
    Prenat Diagn 25:635-40. 2005
    ..To estimate weight and ethnic group correction factors for first-trimester screening markers...
  72. ncbi Immunoassays developed for pregnancy-associated plasma protein-A (PAPP-A) in pregnancy may not recognize PAPP-A in acute coronary syndromes
    Qiu Ping Qin
    Department of Biotechnology, University of Turku, Turku, Finland
    Clin Chem 52:398-404. 2006
    ..We investigated the effect of antibody selection on the utility of PAPP-A assays for measurement of PAPP-A in pregnancy and/or ACS, and whether immunoassays for PAPP-A in pregnancy are suitable for PAPP-A in ACS...
  73. ncbi Screening for pre-eclampsia and fetal growth restriction by uterine artery Doppler and PAPP-A at 11-14 weeks' gestation
    A Pilalis
    First Department of Obstetrics and Gynecology, Alexandra Maternity Hospital, University of Athens, Athens, Greece
    Ultrasound Obstet Gynecol 29:135-40. 2007
    ....
  74. ncbi Low levels of maternal serum PAPP-A in the first trimester and the risk of pre-eclampsia
    Kevin Spencer
    Prenatal Screening Unit, Department of Clinical Biochemistry, King George Hospital, Goodmayes, Essex, UK
    Prenat Diagn 28:7-10. 2008
    ..The objective of this study was to establish the relative risk for pre-eclampsia at various PAPP-A levels as an aid to counselling and follow up of pregnancies...
  75. doi The effect of Rhesus status on first-trimester pregnancy screening markers free beta human chorionic gonadotropin, pregnancy-associated plasma protein-A and nuchal translucency
    Nicholas J Cowans
    Department of Clinical Biochemistry, King George Hospital, Essex, UK
    Prenat Diagn 29:505-7. 2009
    ..To examine whether maternal Rhesus status has any effect on the levels of first-trimester markers free beta-human chorionic gonadotropin (beta-hCG), pregnancy-associated plasma protein-A (PAPP-A) and nuchal translucency (NT)...
  76. ncbi Reference centile chart for fetal nuchal translucency, maternal serum PAPP-A and free beta hCG
    Saifon Chawanpaiboon
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    J Med Assoc Thai 93:154-60. 2010
    ....
  77. ncbi First trimester maternal serum pregnancy-associated plasma protein A and pregnancy-specific beta 1-glycoprotein in fetal trisomies
    N A Bersinger
    Department of Obstetrics and Gynaecology, University of Berne, Switzerland
    Br J Obstet Gynaecol 101:970-4. 1994
    ..CONCLUSION: Maternal serum PAPP-A concentration in the first trimester of pregnancy may prove to be useful in the prediction of risk for fetal trisomies...
  78. ncbi Screening for Down syndrome during first trimester: a prospective study using free beta-human chorionic gonadotropin and pregnancy-associated plasma protein A
    J C Forest
    Department of Biochemistry, Faculty of Medicine, Laval University, Canada
    Clin Biochem 30:333-8. 1997
    ..Our objective was to confirm these results in a prospective study carried on an unselected population...
  79. ncbi Evidence that the insulin-like growth factor binding protein-4 protease in human ovarian follicular fluid is pregnancy associated plasma protein-A
    C A Conover
    Endocrine Research Unit, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    J Clin Endocrinol Metab 84:4742-5. 1999
    ..We have the molecular and biochemical tools to begin to delineate the regulation and biological function of PAPP-A in normal and dysregulated follicular development and atresia...
  80. ncbi Practical strategies in contingent sequential screening for Down syndrome
    Peter Benn
    Department of Genetics and Developmental Biology, University of Connecticut, Health Center, Farmington, CT 06030 6140, USA
    Prenat Diagn 25:645-52. 2005
    ..To design and assess the performance of protocols for contingent sequential Down syndrome screening that can be implemented in practice...
  81. doi Effect of deviation of nuchal translucency measurements on the performance of screening for trisomy 21
    K O Kagan
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, UK
    Ultrasound Obstet Gynecol 33:657-64. 2009
    ....
  82. ncbi The best marker combination using the integrated screening test approach for detecting various chromosomal aneuploidies
    Ron Maymon
    Department of Obstetrics and Gynecology, Assaf Harofe Medical Center, Israel
    J Perinat Med 33:392-8. 2005
    ..To evaluate the cross-trimester multiple marker correlation and the minimum marker combination needed for detecting various chromosomal aneuploidies...
  83. ncbi Maternal serum pregnancy-associated plasma protein A (PAPP-A) but not pregnancy-specific beta1-glycoprotein (SP1) is a useful second-trimester marker for fetal trisomy 18
    N A Bersinger
    Department of Obstetrics and Gynaecology, University of Berne, Switzerland
    Prenat Diagn 19:537-41. 1999
    ....
  84. ncbi Women with preeclampsia have increased serum levels of pregnancy-associated plasma protein A (PAPP-A), inhibin A, activin A and soluble E-selectin
    Nick A Bersinger
    Department of Obstetrics and Gynaecology, University of Berne, Berne, Switzerland
    Hypertens Pregnancy 22:45-55. 2003
    ....
  85. doi Role of uterine artery Doppler in interpreting low PAPP-A values in first-trimester screening for Down syndrome in pregnancies at high risk of impaired placentation
    I Herraiz
    Fetal Medicine Unit, Department of Obstetrics and Gynaecology, Hospital Universitario 12 de Octubre, Madrid, Spain
    Ultrasound Obstet Gynecol 33:518-23. 2009
    ..The aim of this study was to determine whether high UtA resistance plays a role in explaining low PAPP-A levels in the absence of aneuploidies...
  86. ncbi Differential increase in the maternal serum concentrations of the placental proteins human chorionic gonadotrophin, pregnancy-specific beta 1-glycoprotein, human placental lactogen and pregnancy-associated plasma protein-A during the first half of normal
    S Sørensen
    Department of Clinical Chemistry, Hvidovre Hospital, Denmark
    Hum Reprod 10:453-8. 1995
    ..The value was highest for HPL and lowest for PAPP-A...
  87. ncbi In vivo effects of pregnancy-associated plasma protein-A, activin-A and vascular endothelial growth factor on other follicular-fluid factors during follicle deviation in mares
    O J Ginther
    Eutheria Foundation, Cross Plains, Wisconsin 53528, USA
    Reproduction 129:489-96. 2005
    ....
  88. doi The impact of first-trimester serum free beta-human chorionic gonadotropin and pregnancy-associated plasma protein A on the diagnosis of fetal growth restriction and small for gestational age infant
    Laura Montanari
    Department of Obstetrics and Gynecology, University of Pavia, IRCCS Fondazione Policlinico San Matteo, Pavia, Italy
    Fetal Diagn Ther 25:130-5. 2009
    ..To evaluate the risk of fetal growth restriction (FGR) associated with first-trimester maternal serum concentrations of pregnancy-associated plasma protein A (PAPP-A) and free beta-human chorionic gonadotropin (beta-hCG)...
  89. doi Inactivation of insulin-like-growth factors diminished the anabolic effects of pregnancy-associated plasma protein-A (PAPP-A) on bone in mice
    David Phang
    Musculoskeletal Disease Center, Loma Linda University, Loma Linda, CA 92354, United States
    Growth Horm IGF Res 20:192-200. 2010
    ..This clear definition of PAPP-A's mechanism of action is critical for future translational studies on the therapeutic application of PAPP-A...
  90. ncbi [Isolation and purification of pregnancy-associated plasma protein A]
    Y Suzuki
    Department of Obstetrics and Gynecology, Tokyo Medical College
    Nippon Sanka Fujinka Gakkai Zasshi 48:17-24. 1996
    ....
  91. ncbi Early pregnancy levels of pregnancy-associated plasma protein a and the risk of intrauterine growth restriction, premature birth, preeclampsia, and stillbirth
    Gordon C S Smith
    Department of Obstetrics and Gynaecology, Cambridge University, CB2 2QQ, United Kingdom
    J Clin Endocrinol Metab 87:1762-7. 2002
    ..PAPP-A has been identified as a protease specific for IGF binding proteins. We conclude that control of the IGF system in the first and early second trimester trophoblast may have a key role in determining subsequent pregnancy outcome...
  92. ncbi Review: immunomodulatory activity of pregnancy-associated plasma protein-A
    S G Zhabin
    Zonal Perinatal Center, 22 Mettallurgov Av, Novokuznetsk 654007, Russia
    J Clin Lab Immunol 52:41-50. 2003
    ..The experimental data allows us to suppose that PAPP-A serves to prevent the recognition of the fetus by the maternal immune system and to suppress locally the host's immune response to the tumour...
  93. ncbi Speech motor development during acquisition of the voicing contrast
    Maria I Grigos
    The Steinhardt School of Education, New York University, New York 10003, USA
    J Speech Lang Hear Res 48:739-52. 2005
    ..A movement tracking system obtained lip and jaw kinematics as participants produced the target utterances /papa/ and /baba/...
  94. ncbi F2-isoprostanes in kidney transplant patients: relationship with inflammatory markers
    R Lauzurica
    Servicios de Nefrología y Bioquimica, Badalona, Spain
    Transplant Proc 37:3842-3. 2005
    ..Finally, significant correlations were observed between F2-isoprostane isomers and inflammatory markers...
  95. ncbi Molecular analysis of ulilysin, the structural prototype of a new family of metzincin metalloproteases
    Cynthia Tallant
    Departament de Biologia Estructural, Institut de Biologia Molecular de Barcelona, Consejo Superior de Investigaciones Cientificas, C Jordi Girona 18 26, E 08034 Barcelona, Spain
    J Biol Chem 281:17920-8. 2006
    ..Accordingly, ulilysin has higher proteolytic efficiency and a broader substrate specificity than human PAPP-A. The structure of ulilysin represents a prototype for the catalytic domain of pappalysins...
  96. ncbi Identification of P-glycoprotein substrates using open tubular chromatography on an immobilized P-glycoprotein column: Comparison of chromatographic results with Caco-2 permeability
    Ruin Moaddel
    National Institute on Aging, National Institutes of Health, Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, MD 21224 6825, United States
    Anal Chim Acta 578:25-30. 2006
    ..The chromatographic study took 1h to complete and a single pair of columns could be used to screen at least 150 compounds a week and 600 compounds during the 4-week lifetime of the columns...
  97. doi Parentage analysis with few contributing breeders: validation and improvement
    Pierre Duchesne
    Departement de Biologie, Universite Laval, Ste Foy, Quebec, Canada
    J Hered 99:323-34. 2008
    Validation of parental allocation using PAPA software (Duchesne P, Godbout MH, Bernatchez L. 2002. PAPA (package for the analysis of parental allocation): a computer program for simulated and real parental allocation. Mol Ecol Notes...
  98. doi Follicular fluid and serum levels of inhibin A and pregnancy-associated plasma protein A in patients undergoing IVF
    Jiri Moos
    Immunotech as, Prague, Czech Republic
    Fertil Steril 91:1739-44. 2009
    ..To elucidate transport of intrafollicular proteins Inhibin A and pregnancy-associated plasma protein A (PAPP-A) across the follicular fluid (FF)/blood barrier...
  99. doi Pregnancy-associated plasma protein-A and C-reactive protein levels in pre-eclamptic and normotensive pregnant women at third trimester
    Koksal Deveci
    Department of Biochemistry and Clinical Biochemistry, Ataturk Training Hospital, Izmir, Turkey
    J Obstet Gynaecol Res 35:94-8. 2009
    ..The aim of this study was to determine the levels of plasma pregnancy-associated plasma protein-A (PAPP-A) and C-reactive protein (CRP) in pre-eclampsia and their association with the mean arterial blood pressure (MAP)...
  100. doi Pregnancy-associated plasma protein-A as a marker for long-term mortality in patients with peripheral atherosclerosis: inconclusive findings from the Linz Peripheral Arterial Disease (LIPAD) study
    Thomas Mueller
    Department of Laboratory Medicine, Konventhospital Barmherzige Brueder, Linz, Austria
    Clin Chem Lab Med 48:537-42. 2010
    ..Pregnancy-associated plasma protein-A (PAPP-A) has been associated with peripheral artery disease (PAD). The aim of this study was to evaluate the utility of PAPP-A as a marker for long-term mortality in patients with atherosclerotic PAD...
  101. pmc Biomarkers in acute myocardial infarction
    Daniel Chan
    Leicester National Institute for Health Research Cardiovascular Biomedical Research Unit, UK
    BMC Med 8:34. 2010
    ..b>Pregnancy associated plasma protein A levels following chest pain predicts risk of myocardial infarction and revascularisation...

Research Grants45

  1. Role of PAPP-A in Atherosclerosis
    Cheryl A Conover; Fiscal Year: 2012
    ....
  2. Poor nutrition and fetal development: preadipocyte adaptation in a primate model
    YOURKA DIMOVA TCHOUKALOVA; Fiscal Year: 2010
    ..It is important to identify developmental mechanisms involved as they emerge to develop diagnostic, preventative and therapeutic strategies. ..
  3. Cheryl A Conover; Fiscal Year: 2016
    ..Impact: Our findings could have clinical implications for novel strategies using PAPP-A as a preventive target for visceral fat accumulation and its life-shortening morbidities. ..
  4. THE PHYSIOLOGY OF IGFBP DEGRADING PROTEINASES IN BONE
    John Fowlkes; Fiscal Year: 2009
    ..abstract_text> ..
  5. Identification of Alternative Substrates of Pregnancy-Associated Plasma Protein-A
    James Lawrence; Fiscal Year: 2008
    ..This goal of this application is to investigate and discover a direct link between PAPP-A proteolytic activity and known or novel biological systems. [unreadable] [unreadable] [unreadable] [unreadable]..
  6. MECHANISMS OF ACTIVATION OF ICE-LIKE CYSTEINE PROTEASES
    Emad S Alnemri; Fiscal Year: 2012
    ..mutated in familial Mediterranean fever, in caspase-1 activation and inflammation in the human auto-inflammatory PAPA syndrome, and demonstrated that pyrin is a homotrimeric cytosolic receptor for the cytoskeleton- organizing protein ..
  7. Emad S Alnemri; Fiscal Year: 2016
    ..with two further auto-inflammatory diseases, known as pyogenic arthritis, pyoderma gangrenosum, acne syndrome (PAPA) and chronic multifocal osteomyelitis (cmo) syndrome, respectively...
  8. Todd B Reynolds; Fiscal Year: 2015
    ..only if PS synthesis is inhibited, because otherwise the fungus will be killed by a PS-binding toxin, papuamide A (PapA). This screen is based on the observation that PapA kills C...
  9. Role of PSTPIP1 in a Mouse Model of PAPA Syndrome
    Donghai Wang; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Pyrogenic arthritis, pyoderma gangrenosum and acne (PAPA) syndrome, previously referred to as streaking leucocyte factor disease, is a rare autosomal dominant autoinflammatory disorder characterized ..
  10. Methane Monoxygenase Structure and Function
    John Lipscomb; Fiscal Year: 2009
    ..pathway for chloramphenicol in Streptomyces, where it catalyzes ?-hydroxylation of L-p aminophenylalanine (PAPA)...
  11. John D Lipscomb; Fiscal Year: 2015
    ..it is complexed with its NRPS (CmlP) covalently loaded with the chloramphenicol precursor L-p-NH2-phenylalanine (PAPA) on its thiolation domain...
  12. Molecular Etiology of Familial Mediterranean Fever
    Deborah Gumucio; Fiscal Year: 2007
    ..family members have already been connected to several human diseases, including inflammatory bowel disease, PAPA syndrome, Muckle-Wells sydrome, familial cold urticaria, Blau syndrome and Be_het's disease.
  13. Eric D Ross; Fiscal Year: 2016
    ..Preliminary attempts to define the sequence basis for aggregation of PrLDs recently resulted in the development of PAPA (Prion Aggregation Prediction Algorithm), the first algorithm demonstrated to be able to distinguish between ..
  14. Outcomes of Preschool Mental Health Problems
    Adrian Angold; Fiscal Year: 2009
    ..study of a psychiatric diagnostic interview for parents of preschoolers (the Preschool Age Psychiatric Assessment- PAPA)...
  15. Assessing Preschool Comorbidity: A Test-Retest Study
    Adrian Angold; Fiscal Year: 2002
    ..interview suitable for assessment of comorbidity in very young children - the Preschool Age Psychiatric Assessment (PAPA). No reliability or validity data are available for any diagnostic interview for preschoolers...
  16. Temporal Coordination in the Motor Speech System
    Kirrie Ballard; Fiscal Year: 2006
    ..lip closure, peak velocity and acceleration of lip closing and opening) of the lips and jaw in the production of/papa/under typical and perturbed conditions...
  17. DEGP PROTEINASE INHIBITORS: NOVEL ANTI-INFECTIVES
    C Jones; Fiscal Year: 2000
    ..We have identified the major pilin subunit of the Pap pilus, PapA, as a native DegP substrate and demonstrate binding and proteolysis of this substrate in vitro...
  18. Paracrine IGF/GFBP Interactions In Vivo
    James Fagin; Fiscal Year: 2007
    ..abstract_text> ..
  19. DEGP PROTEINASE INHIBITORS: NOVEL ANTI-INFECTIVES
    Dennis Hruby; Fiscal Year: 2003
    ..We have identified the major pilin subunit of the Pap pilus, PapA, as a native DegP substrate and demonstrate vigorous proteolysis of this substrate in vitro...
  20. PAPAOLA LOKAHI INTERNET CONNECTION
    LAURELLE LEE; Fiscal Year: 1999
    DESCRIPTION (adapted from the Abstract): Papa Ola Lokahi is a private, not for profit health administration organization mandated to serve Native Hawaiians in the State of Hawaii...
  21. Insulin-like Growth Factors in Physiology and Disease
    Cheryl Conover; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  22. Association between Mortality and Long-term Exposure to Outdoor Air Pollution in
    Haidong Kan; Fiscal Year: 2010
    ..The findings of this study will fill key knowledge gap of air pollution health effects in China. ..
  23. Triple Quadrupole Mass Spectrometer With HPLC System
    Stanley Hazen; Fiscal Year: 2005
    ..abstract_text> ..
  24. TRIPLE QUADRUPOLE SPECTROMETRY SYSTEM
    Stanley Hazen; Fiscal Year: 2001
    ..abstract_text> ..
  25. Inhibin/Activin Family in Human Cranifocial Development
    Geralyn Messerlian; Fiscal Year: 2003
    ..abstract_text> ..
  26. SELECTION OF THE DOMINANT FOLLICLE AND THE IGF SYSTEM
    JOANNE FORTUNE; Fiscal Year: 2003
    ..abstract_text> ..
  27. MYELOPEROXIDASE, OXIDANT STRESS AND ATHEROGENESIS
    Stanley Hazen; Fiscal Year: 2004
    ....
  28. 7th Intl Symposium-Neurobiology/Neuroendocrinology/Aging
    Andrzej Bartke; Fiscal Year: 2004
    ..We are also seeking support for the presenters of the Special Lecture and the Keynote Lecture who will be traveling to Bregenz from the United States. ..
  29. Determinants of Atherosclerotic Plaque Progression
    Stanley Hazen; Fiscal Year: 2004
    ..abstract_text> ..
  30. Molecular Mechanisms of Ovarian Follicular Activation
    JOANNE FORTUNE; Fiscal Year: 2004
    ..Elucidation of these fundamental mechanisms has practical implications for the development of new contraceptive technologies and alleviation of infertility. ..
  31. DEVELOPMENTAL EPIDEMIOLOGY OF ANXIETY IN PRESCHOOLERS
    Helen Egger; Fiscal Year: 2005
    ..DSM-IV and DC:0-3 diagnoses and symptoms will be assessed using the Preschool Age Psychiatric Assessment (PAPA), a structured parent interview developed by the candidate. 3...
  32. Biomarkers for Complications in Type 1 Diabetes (DCCT/EDIC)
    Stanley L Hazen; Fiscal Year: 2010
    ..These analyses may give insights into whether the effects of glycemic control on the complications of diabetes are mediated through any of the proposed biomarkers. ..
  33. Structure & function of bacterial adhesion pili
    Esther Bullitt; Fiscal Year: 2009
    ..Studies will use optical tweezers to measure the forces necessary to damage P-pili expressed on uropathogenic bacteria, and to investigate whether recovery occurs. 4) localize the adhesins on type 1 pili using immunoelectron microscopy. ..
  34. Regulation of Prostaglandins in Periovulatory Follicles
    JOANNE FORTUNE; Fiscal Year: 2005
    ..Together these experiments will provide new knowledge about the regulation of, and relationship between, these two essential mediators of ovulation and their receptors. ..
  35. Ultrafast laser-based x-ray in-vivo phase-contrast micro-CT
    Andrzej Krol; Fiscal Year: 2006
    ..abstract_text> ..
  36. Aging:Mechanisms & Prevention:34th Annual Meeting of AGE
    Andrzej Bartke; Fiscal Year: 2005
    ..Financial assistance will be provided to those in training to encourage their participation in the meeting. ..
  37. Resistant E.coli in Humans and Poultry
    James Johnson; Fiscal Year: 2005
    ..Does the research address a current and compelling problem of antimicrobial resistance that is of high public health importance and for which research is needed? [yes]. ..
  38. Peroxidases and Asthma
    Stanley Hazen; Fiscal Year: 2005
    ..Finally, we will test the hypothesis that specific protein oxidative modifications and cross-links correlate with the extent of airways remodeling and the degree of fixed obstructive disease. ..
  39. San Antonio Comparative Biology of Aging Center
    Steven Austad; Fiscal Year: 2008
    ..abstract_text> ..
  40. Oxygen Radicals 2008 Gordon Research Conference
    Stanley Hazen; Fiscal Year: 2008
    ..End of Abstract) [unreadable] [unreadable] [unreadable]..
  41. Comparative Mechanisms of Exceptionally Slow Aging
    Steven Austad; Fiscal Year: 2007
    ..g. low ROS production per level of electron flux) might generally affect aging rate. ..
  42. Eighth & Ninth International Symposia on Neurobiology & Neuroendocrinology Aging
    Andrzej Bartke; Fiscal Year: 2007
    ..We are also seeking partial support for the expenses of invited speakers from the United States. [unreadable] [unreadable] [unreadable]..
  43. Genetic Basis of chronic Multifocal Osteomyelitis
    Polly Ferguson; Fiscal Year: 2007
    ..abstract_text> ..
  44. White matter damage in the developing mouse brain
    Wayne Price; Fiscal Year: 2007
    ..The development of mouse models of WMD will facilitate research defining the pathogenesis of this disorder, and will suggest prevention and treatment strategies for use in the human neonate. [unreadable] [unreadable]..
  45. Phospholipid Oxidation and the Scavenger Receptor CD36
    Stanley Hazen; Fiscal Year: 2006
    ..2) To examine the physiological relevance of specific oxidized phospholipid ligands for CD36 and define pathways through which leukocyte-generated oxidants participate in their formation in vivo. ..