PRDX3

Summary

Gene Symbol: PRDX3
Description: peroxiredoxin 3
Alias: AOP-1, AOP1, HBC189, MER5, PRO1748, SP-22, prx-III, thioredoxin-dependent peroxide reductase, mitochondrial, antioxidant protein 1, peroxiredoxin III, protein MER5 homolog
Species: human

Top Publications

  1. ncbi Copurification of vimentin, energy metabolism enzymes, and a MER5 homolog with nucleoside diphosphate kinase. Identification of tissue-specific interactions
    A S Otero
    Department of Molecular Physiology and Biological Physics, University of Virginia Medical School, Charlottesville, Virginia 22906, USA
    J Biol Chem 272:14690-4. 1997
  2. pmc The c-Myc target gene PRDX3 is required for mitochondrial homeostasis and neoplastic transformation
    Diane R Wonsey
    Program in Human Genetics and Molecular Biology and Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 99:6649-54. 2002
  3. pmc Nonredundant antioxidant defense by multiple two-cysteine peroxiredoxins in human prostate cancer cells
    Chuanlu Shen
    Department of Microbiology and Immunology, Weill Medical College, Cornell University, New York, New York 10021, USA
    Mol Med 8:95-102. 2002
  4. ncbi Overexpression of mitochondrial thioredoxin reductase and peroxiredoxin III in hepatocellular carcinomas
    Joon Hyuk Choi
    Department of Pathology, College of Medicine, Yeungnam University, Daegu, 705 717, Korea
    Anticancer Res 22:3331-5. 2002
  5. ncbi Peroxiredoxin III, a mitochondrion-specific peroxidase, regulates apoptotic signaling by mitochondria
    Tong Shin Chang
    Laboratory of Cell Signaling, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:41975-84. 2004
  6. ncbi RPK118, a PX domain-containing protein, interacts with peroxiredoxin-3 through pseudo-kinase domains
    Lingling Liu
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai 200433, China
    Mol Cells 19:39-45. 2005
  7. ncbi Localization and H2O2-specific induction of PRDX3 in the eye lens
    Wanda Lee
    Department of Biomedical Science, Florida Atlantic University, Boca Raton, FL 33431, USA
    Mol Vis 13:1469-74. 2007
  8. doi Silencing of peroxiredoxin 3 and peroxiredoxin 5 reveals the role of mitochondrial peroxiredoxins in the protection of human neuroblastoma SH-SY5Y cells toward MPP+
    Stéphanie De Simoni
    Laboratory of Cell Biology, Institut des Sciences de la Vie, Universite Catholique de Louvain, 5 Place Croix du Sud, 1348 Louvain la Neuve, Belgium
    Neurosci Lett 433:219-24. 2008
  9. pmc Reduction of mitochondrial H2O2 by overexpressing peroxiredoxin 3 improves glucose tolerance in mice
    Liuji Chen
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, Texas 78229, USA
    Aging Cell 7:866-78. 2008
  10. pmc Sulfiredoxin Translocation into Mitochondria Plays a Crucial Role in Reducing Hyperoxidized Peroxiredoxin III
    You Hyun Noh
    College of Pharmacy, Division of Life and Pharmaceutical Sciences, and Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Science Building C, 11 1 Daehyun Dong, Seodaemun gu, Seoul 120 750, Korea
    J Biol Chem 284:8470-7. 2009

Scientific Experts

Detail Information

Publications127 found, 100 shown here

  1. ncbi Copurification of vimentin, energy metabolism enzymes, and a MER5 homolog with nucleoside diphosphate kinase. Identification of tissue-specific interactions
    A S Otero
    Department of Molecular Physiology and Biological Physics, University of Virginia Medical School, Charlottesville, Virginia 22906, USA
    J Biol Chem 272:14690-4. 1997
    ..The results suggest that while NDP kinase is associated with vimentin intermediate filaments and an antioxidant protein in most tissues, it interacts with energy metabolism enzymes in a tissue-specific manner...
  2. pmc The c-Myc target gene PRDX3 is required for mitochondrial homeostasis and neoplastic transformation
    Diane R Wonsey
    Program in Human Genetics and Molecular Biology and Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 99:6649-54. 2002
    ..Here, we describe a nuclear c-Myc target gene, PRDX3, which encodes a mitochondrial protein of the peroxiredoxin gene family...
  3. pmc Nonredundant antioxidant defense by multiple two-cysteine peroxiredoxins in human prostate cancer cells
    Chuanlu Shen
    Department of Microbiology and Immunology, Weill Medical College, Cornell University, New York, New York 10021, USA
    Mol Med 8:95-102. 2002
    ..Because mammalian Prxs have not been experimentally deleted or inhibited, it is not known how much they contribute to antioxidant defense, nor whether the multiple isoforms afford redundant or additive protection...
  4. ncbi Overexpression of mitochondrial thioredoxin reductase and peroxiredoxin III in hepatocellular carcinomas
    Joon Hyuk Choi
    Department of Pathology, College of Medicine, Yeungnam University, Daegu, 705 717, Korea
    Anticancer Res 22:3331-5. 2002
    Thioredoxin reductase 2 (TrxR2), thioredoxin II (Trx II) and peroxiredoxin III (Prx III) are specifically localized in mitochondria and believed to play important roles in the regulation of cellular redox status by serving as a primary ..
  5. ncbi Peroxiredoxin III, a mitochondrion-specific peroxidase, regulates apoptotic signaling by mitochondria
    Tong Shin Chang
    Laboratory of Cell Signaling, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:41975-84. 2004
    ..Depletion of Prx III resulted in increased intracellular levels of H(2)O(2) and sensitized cells to induction of apoptosis by ..
  6. ncbi RPK118, a PX domain-containing protein, interacts with peroxiredoxin-3 through pseudo-kinase domains
    Lingling Liu
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai 200433, China
    Mol Cells 19:39-45. 2005
    ..In this study we identified a novel RPK118-binding protein, PRDX3 (peroxiredoxin-3), by yeast two-hybrid screening...
  7. ncbi Localization and H2O2-specific induction of PRDX3 in the eye lens
    Wanda Lee
    Department of Biomedical Science, Florida Atlantic University, Boca Raton, FL 33431, USA
    Mol Vis 13:1469-74. 2007
    b>Peroxiredoxin III (PRDX3) is a mitochondrial peroxidase that defends cells against oxidative damage and therefore could play a role in cataract formation...
  8. doi Silencing of peroxiredoxin 3 and peroxiredoxin 5 reveals the role of mitochondrial peroxiredoxins in the protection of human neuroblastoma SH-SY5Y cells toward MPP+
    Stéphanie De Simoni
    Laboratory of Cell Biology, Institut des Sciences de la Vie, Universite Catholique de Louvain, 5 Place Croix du Sud, 1348 Louvain la Neuve, Belgium
    Neurosci Lett 433:219-24. 2008
    Peroxiredoxins (PRDXs) are a family of peroxidases well conserved throughout evolution. Human PRDX3 and PRDX5, two mitochondrial PRDXs, have been implicated in several pathologies associated with oxidative stress...
  9. pmc Reduction of mitochondrial H2O2 by overexpressing peroxiredoxin 3 improves glucose tolerance in mice
    Liuji Chen
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, Texas 78229, USA
    Aging Cell 7:866-78. 2008
    ..Peroxiredoxin 3 (Prdx3/Prx3) is a thioredoxin peroxidase localized in mitochondria...
  10. pmc Sulfiredoxin Translocation into Mitochondria Plays a Crucial Role in Reducing Hyperoxidized Peroxiredoxin III
    You Hyun Noh
    College of Pharmacy, Division of Life and Pharmaceutical Sciences, and Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Science Building C, 11 1 Daehyun Dong, Seodaemun gu, Seoul 120 750, Korea
    J Biol Chem 284:8470-7. 2009
    ..However, whereas Srx is localized in the cytoplasm, Prx III is present exclusively in the mitochondria...
  11. ncbi Expression of human peroxiredoxin isoforms in response to cervical carcinogenesis
    Kiyoon Kim
    Department of Biochemistry and Molecular Biology, Medical Science and Engineering Research Center for Bioreaction to Reactive Oxygen Species, Biomedical Science Institute, Kyunghee University School of Medicine, Seoul 130 701, Korea
    Oncol Rep 21:1391-6. 2009
    ..No difference in staining intensity by grade of lesion was observed for Prx I, and IV. Therefore, we conclude that Prx II and III are upregulated in response to the development of cervical cancer...
  12. doi Redox potential and peroxide reactivity of human peroxiredoxin 3
    Andrew G Cox
    Free Radical Research Group and National Research Centre for Growth and Development, Department of Pathology, University of Otago, Christchurch, New Zealand
    Biochemistry 48:6495-501. 2009
    ..Using dithiothreitol redox buffers, we measured the redox potential of Prx 3 of -290 mV. This is similar to the redox potential of mitochondrial thioredoxin 2 and is consistent with optimal operation of Prx 3 in the mitochondrial matrix...
  13. ncbi Silencing the Peroxiredoxin III gene inhibits cell proliferation in breast cancer
    Pei Jou Chua
    Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, and Department of Pathology, Singapore General Hospital, MD10, S 117 597, Singapore
    Int J Oncol 36:359-64. 2010
    b>Peroxiredoxin III (Prx III), an antioxidant protein found in mitochondria, plays an essential role in mitochondrial homeostasis. Aberrant expression of Prx III has been implicated in the tumorigenesis of various cancers...
  14. doi Removal of amino acid, peptide and protein hydroperoxides by reaction with peroxiredoxins 2 and 3
    Alexander V Peskin
    Free Radical Research Group, Department of Pathology, University of Otago, Christchurch, New Zealand
    Biochem J 432:313-21. 2010
    ..Prxs are therefore favoured intracellular targets for peptide/protein hydroperoxides and have the potential to detoxify these species in vivo...
  15. pmc Both thioredoxin 2 and glutaredoxin 2 contribute to the reduction of the mitochondrial 2-Cys peroxiredoxin Prx3
    Eva Maria Hanschmann
    Institut für Klinische Zytobiologie und Zytopathologie, Fachbereich Medizin, Philipps Universitat, DE 35037 Marburg, Germany
    J Biol Chem 285:40699-705. 2010
    ..These results introduce Grx2 as a novel electron donor for Prx3, providing further insights into pivotal cellular redox signaling mechanisms...
  16. pmc Differential expression of peroxiredoxins in prostate cancer: consistent upregulation of PRDX3 and PRDX4
    Anamika Basu
    Center for Health Disparities and Molecular Medicine, Loma Linda University School of Medicine, Loma Linda, California 92350, USA
    Prostate 71:755-65. 2011
    ..Because their significance in prostate cancer (PCa) is unclear, we investigated their expression and clinical associations in PCa...
  17. doi Peroxiredoxins 3 and 4 are overexpressed in prostate cancer tissue and affect the proliferation of prostate cancer cells in vitro
    Ramesh Ummanni
    Department of Oncology, Haematology and Bone Marrow Transplantation, Section Pneumology, Hubertus Wald Tumour Zentrum, University Hospital Eppendorf, Hamburg, Germany
    J Proteome Res 11:2452-66. 2012
    ..and mass spectrometry were performed for protein identification, and data validation for peroxiredoxin 3 and 4 (PRDX3 and PRDX4) was accomplished by reverse phase protein arrays (RPPA)...
  18. doi MicroRNA-23b downregulates peroxiredoxin III in human prostate cancer
    Hui Chan He
    Department of Urology, Guangdong Key Laboratory of Clinical Molecular Medicine and Diagnostics, Guangzhou First Municipal People s Hospital, Affiliated Guangzhou Medical College, Guangzhou 510180, China
    FEBS Lett 586:2451-8. 2012
    To investigate the mechanism by which peroxiredoxin III (PRDX3) is altered in human prostate cancer (PCa), we used microRNA (miRNA) target prediction program and miRNA microarray to predict and identify miR-23b as a candidate miRNA that ..
  19. pmc Mitochondrial-targeted nitroxides disrupt mitochondrial architecture and inhibit expression of peroxiredoxin 3 and FOXM1 in malignant mesothelioma cells
    Brian Cunniff
    Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    J Cell Physiol 228:835-45. 2013
    ....
  20. ncbi SP-22 is a thioredoxin-dependent peroxide reductase in mitochondria
    S Watabe
    Radioisotope Laboratory, Faculty of Agriculture, Yamaguchi University, Japan
    Eur J Biochem 249:52-60. 1997
    ..From these results we concluded that SP-22 is thioredoxin-dependent peroxide reductase or so-called thioredoxin peroxidase in mitochondria from the adrenal cortex...
  21. ncbi Mitochondrial thioredoxin reductase in bovine adrenal cortex its purification, properties, nucleotide/amino acid sequences, and identification of selenocysteine
    S Watabe
    Radioisotope Laboratory, Faculty of Agriculture, Yamaguchi University, Japan
    Eur J Biochem 264:74-84. 1999
    ..Our data clearly show that mitochondria, which might have originated from symbiotic prokaryotes, contain thioredoxin reductase similar to the cytosolic enzyme and different from the bacterial one...
  22. ncbi A human cDNA corresponding to a gene overexpressed during cell proliferation encodes a product sharing homology with amoebic and bacterial proteins
    M T Prosperi
    Laboratoire d Oncogenèse, Institut Curie, Paris, France
    J Biol Chem 268:11050-6. 1993
    ..codes for a 22-kDa protein, devoid of known consensus motifs, and shares 66% homology with a murine gene product (MER5) that is preferentially expressed in erythroleukemia cells during the early period of cell differentiation...
  23. ncbi Thioredoxin-dependent peroxide reductase from yeast
    H Z Chae
    Laboratory of Biochemistry, NHLBI, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 269:27670-8. 1994
    ..The Saccharomyces cerevisiae thioredoxin reductase gene was also cloned and sequenced, and the deduced amino sequence was shown to be 51% identical with that of the Escherichia coli enzyme...
  24. ncbi Common deleted genes in the 5q- syndrome: thrombocytopenia and reduced erythroid colony formation in SPARC null mice
    S Lehmann
    Division of Hematology Oncology, Cedars Sinai Medical Center, School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    Leukemia 21:1931-6. 2007
    ..36, member 1 (SLC36A1; 89% downregulated), Ras-GTPase-activating protein SH3 domain-binding (G3BP; 79%), antioxidant protein 1 (ATOX1; 76%), colony-stimulating factor-1 receptor precursor (CSF1R; 76%), ribosomal protein S14 (RPS14; ..
  25. doi The role of enoyl-CoA hydratase short chain 1 and peroxiredoxin 3 in PP2-induced apoptosis in human breast cancer MCF-7 cells
    Xiang Liu
    College of Life Sciences, Peking University, Beijing, PR China
    FEBS Lett 584:3185-92. 2010
    ..apoptosis and down-regulates the expression of enoyl-CoA hydratase short chain 1 (ECHS1) and peroxiredoxin 3 (PRDX3) in human breast cancer MCF-7 cells...
  26. ncbi Evolutionary history of sex-linked mammalian amelogenin genes
    Mineyo Iwase
    Department of Biosystems Science, Graduate University for Advanced Studies, Hayama, Japan
    Cells Tissues Organs 186:49-59. 2007
    ..genes too differentiated from each other in two steps; first in the 5' region (the promoter region to transposon MER5 in intron 2) and second in the remaining 3' region...
  27. ncbi Cloning of a housekeeping-type gene (MER5) preferentially expressed in murine erythroleukemia cells
    T Yamamoto
    Department of Cell Biology, Tohoku University, Sendai, Japan
    Gene 80:337-43. 1989
    ..An open reading frame was noted in the cloned DNA, and was tentatively designated MER5. The MER5 mRNA is abundant in three MEL cell lines, but less in other tissues or cell lines...
  28. ncbi Cloning of bovine peroxiredoxins-gene expression in bovine tissues and amino acid sequence comparison with rat, mouse and primate peroxiredoxins
    Gregory Leyens
    Unité des Sciences vétérinaires, Institut des Sciences de la Vie, Universite Catholique de Louvain, Place Croix du Sud 5, B 1348 Louvain la Neuve, Belgium
    Comp Biochem Physiol B Biochem Mol Biol 136:943-55. 2003
    ..b>PRDX3 and PRDX6 had previously been cloned and characterized in bovine...
  29. ncbi The mitochondrial type II peroxiredoxin F is essential for redox homeostasis and root growth of Arabidopsis thaliana under stress
    Iris Finkemeier
    Department of Plant Physiology and Biochemistry, University of Bielefeld, 33501 Bielefeld, Germany
    J Biol Chem 280:12168-80. 2005
    ..Therefore, it might be assumed to have functions similar to the human 2-Cys Prx (PRDX3) and type II Prx (PRDX5) and yeast 1-Cys Prx that likewise have mitochondrial localizations...
  30. pmc FoxM1, a critical regulator of oxidative stress during oncogenesis
    Hyun Jung Park
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA
    EMBO J 28:2908-18. 2009
    ..in turn, downregulates ROS levels by stimulating expression of ROS scavenger genes, such as MnSOD, catalase and PRDX3. FoxM1 depletion sensitizes cells to oxidative stress and increases oncogene-induced premature senescence...
  31. ncbi Characterization of human and murine PMP20 peroxisomal proteins that exhibit antioxidant activity in vitro
    H Yamashita
    Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 274:29897-904. 1999
    ..Because some portion of PMP20 might also be present in the cytosol, HsPMP20 may also have a protective effect in the cytoplasm...
  32. ncbi Cloning and characterization of AOEB166, a novel mammalian antioxidant enzyme of the peroxiredoxin family
    B Knoops
    Laboratory of Cell Biology, Department of Biology, Universite Catholique de Louvain, 1348 Louvain la Neuve, Belgium
    J Biol Chem 274:30451-8. 1999
    ..Finally, acute inflammation induced in rat lung by lipopolysaccharide is associated with an increase of AOEB166 mRNA levels in lung, suggesting a protective role for AOEB166 in oxidative and inflammatory processes...
  33. ncbi Reconstitution of the mitochondrial PrxIII antioxidant defence pathway: general properties and factors affecting PrxIII activity and oligomeric state
    Zhenbo Cao
    Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, Scotland, UK
    J Mol Biol 372:1022-33. 2007
    ..Moreover, concatenated PrxIII C168S reverts to single toroids on crystal dissolution indicating that these higher-order structures are produced dynamically during the crystallisation process...
  34. pmc Peroxiredoxin 3 (PDRX3) is highly expressed in the primate retina especially in blue cones
    Ernesto F Moreira
    Mechanisms of Retinal Disease Section, LRCMB, National Eye Institute, NIH, Bethesda, MD 20892, USA
    Exp Eye Res 86:452-5. 2008
    ..b>Peroxiredoxin III (PRDX3) is one of a family of six known peroxiredoxins which are known to protect cells against oxidative ..
  35. ncbi Stress-induced peroxiredoxins
    Tetsuro Ishii
    Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, 305 8575 Japan
    Subcell Biochem 44:375-84. 2007
    ..Gene expression of both Prx I and II is activated by X-ray irradiation of the testis. Mitochondrial Prx III is up-regulated by stress agents in both cultured cells and experimental animals...
  36. pmc Oxidative damage increases and antioxidant gene expression decreases with aging in the mouse ovary
    Jinhwan Lim
    Department of Medicine, University of California, Irvine, CA, USA
    Biol Reprod 84:775-82. 2011
    ..increased and expression of glutaredoxin 1 (Glrx1), glutathione S-transferase mu 2 (Gstm2), peroxiredoxin 3 (Prdx3), and thioredoxin 2 (Txn2) decreased in a statistically significant manner with age...
  37. doi Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death
    Dario C Angeles
    Neuroscience Laboratory, Singapore Health Services Research Facilities, Singapore
    Hum Mutat 32:1390-7. 2011
    ..Here, we show that LRRK2 interacts with human peroxiredoxin 3 (PRDX3), a mitochondrial member of the antioxidant family of thioredoxin (Trx) peroxidases...
  38. doi MiR-383 is downregulated in medulloblastoma and targets peroxiredoxin 3 (PRDX3)
    Kay Ka Wai Li
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong
    Brain Pathol 23:413-25. 2013
    ..By transcriptomic analysis and computational algorithms, we identified peroxiredoxin 3 (PRDX3) as a target gene of miR-383...
  39. doi siRNA targeting of PRDX3 enhances cisplatin‑induced apoptosis in ovarian cancer cells through the suppression of the NF‑κB signaling pathway
    Jie Duan
    Gynecology, Maternal and Child Health Hospital of Hubei Province, Wuhan, Hubei 430070, PR China
    Mol Med Rep 7:1688-94. 2013
    ..The present study aimed to investigate the effect and mechanism of the downregulation of PRDX3 on cisplatin‑induced ovarian cancer cell apoptosis...
  40. doi Modulation of the peroxiredoxin system by cytokines in insulin-producing RINm5F cells: down-regulation of PRDX6 increases susceptibility of beta cells to oxidative stress
    Flavia M M Paula
    Department of Anatomy, Cellular Biology and Physiology and Biophysics, Institute of Biology, State University of Campinas, UNICAMP, Campinas, Brazil
    Mol Cell Endocrinol 374:56-64. 2013
    ..RINm5F cells expressed significant amounts of PRDX1, PRDX3 and PRDX6 enzymes...
  41. pmc Peroxiredoxin-3 is overexpressed in prostate cancer and promotes cancer cell survival by protecting cells from oxidative stress
    H C Whitaker
    Uro Oncology Research Group, Cambridge CB2 0RE, UK
    Br J Cancer 109:983-93. 2013
    ..PRDX-3 is a member of the peroxiredoxin family that are responsible for neutralising reactive oxygen species...
  42. pmc Lymphocyte mitochondria: toward identification of peripheral biomarkers in the progression of Alzheimer disease
    Rukhsana Sultana
    Department of Chemistry, Center of Membrane Sciences, Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40506 0055, USA
    Free Radic Biol Med 65:595-606. 2013
    ..Increased understanding of oxidative stress and protein alterations in easily obtainable peripheral tissues will be helpful in developing biomarkers to combat this devastating disorder. ..
  43. pmc Molecular basis for the resistance of human mitochondrial 2-Cys peroxiredoxin 3 to hyperoxidation
    Alexina C Haynes
    From the Center for Structural Biology and Department of Biochemistry
    J Biol Chem 288:29714-23. 2013
    ..Given the oxidizing environment of the mitochondrion, it makes sense that Prx3 would favor disulfide bond formation as a protection mechanism against hyperoxidation and inactivation. ..
  44. doi Peroxiredoxin 2 nuclear levels are regulated by circadian clock synchronization in human keratinocytes
    Daniele Avitabile
    Istituto Pasteur Fondazione Cenci Bolognetti, Dipartimento di Medicina Clinica e Molecolare, Sapienza Universita di Roma, Rome, Italy Laboratiorio Biologia Vascolare e Medicina Rigenerativa, Centro Cardiologico Monzino IRCCS, Milan, Italy Electronic address
    Int J Biochem Cell Biol 53:24-34. 2014
    ..Donwregulation of PRDX2 resulted in upregulation of the mitochondrion-specific Peroxiredoxin 3 (PRDX3), all other members of the Peroxiredoxin family remained unaltered...
  45. ncbi Serum peroxiredoxin3 is a useful biomarker for early diagnosis and assessemnt of prognosis of hepatocellular carcinoma in Chinese patients
    Liang Shi
    Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical Uiniversity, Wenzhou, China E mail
    Asian Pac J Cancer Prev 15:2979-86. 2014
    Recently, peroxiredoxin3 (PRDX3) was identified as a novel molecular marker for the progression of hepatocellular carcinoma (HCC)...
  46. pmc MicroRNA-26a-5p and microRNA-23b-3p up-regulate peroxiredoxin III in acute myeloid leukemia
    Wenjie Jiang
    Key Laboratory of Experimental Teratology, Ministry of Education, Institute of Medical Genetics, School of Medicine, Shandong University, Jinan, Shandong, China
    Leuk Lymphoma 56:460-71. 2015
    ..Notably, we demonstrated that peroxiredoxin III (PrxIII) is a common direct target of both miR-26a-5p and miR-23b-3p...
  47. doi Hypoxia inducible factor-1α suppresses Peroxiredoxin 3 expression to promote proliferation of CCRCC cells
    Hao Xi
    Department of Pathology, Shanghai Tenth People s Hospital, Tongji University, Shanghai 200072, PR China
    FEBS Lett 588:3390-4. 2014
    ..and chromatin-immunoprecipitation assays indicated that HIF-1α binds to the hypoxia-responsive elements of PRDX3 promoter and represses its transcription...
  48. doi P6.15peroxiredoxin 3 as a molecular therapeutic target in breast cancer
    P J Chua
    National University of Singapore, Singapore, Singapore
    Ann Oncol 26:ii30. 2015
    ..Each PRDX has diverse functions, which include regulating cell signaling associated with hydrogen peroxide. PRDX3, known to be found exclusively in the mitochondria, has been reported to be elevated in several types of ..
  49. pmc Accelerated hepatocellular carcinoma development in CUL4B transgenic mice
    Jupeng Yuan
    Key Laboratory of Experimental Teratology, Ministry of Education, Institute of Molecular Medicine and Genetics, Shandong University School of Medicine, Jinan, China
    Oncotarget 6:15209-21. 2015
    ..We also found that Prdx3 was downregulated and that DEN induced a higher level of reactive oxygen species in the livers of transgenic mice...
  50. pmc FOXO responses to Porphyromonas gingivalis in epithelial cells
    Qian Wang
    Department of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, KY, USA
    Cell Microbiol 17:1605-17. 2015
    ..PCR demonstrated that transcription of genes involved in protection against oxidative stress (Cat, Sod2, Prdx3), inflammatory responses (IL1β) and anti-apoptosis (Bcl-6) was induced by P...
  51. pmc Species-Related Differences in the Proteome of Rat and Human Pancreatic Beta Cells
    G A Martens
    B Probe, Diabetes Research Center, Brussels Free University VUB, Belgium Department of Clinical Chemistry and Radioimmunology, University Hospital Brussels, Laarbeeklaan 103, 1090 Brussels, Belgium
    J Diabetes Res 2015:549818. 2015
    ..and radical scavenging systems: apart from SOD2, they expressed high levels of H2O2-scavenger peroxiredoxin 3 (PRDX3), confirmed by microarray, Western blotting, and microscopy...
  52. doi Quantitative tissue proteomic investigation of invasive ductal carcinoma of breast with luminal B HER2 positive and HER2 enriched subtypes towards potential diagnostic and therapeutic biomarkers
    Namita Pendharkar
    Proteomics Lab, National Centre for Cell Science, Ganeshkhind, Pune 411007, MH, India B J Medical College, Sassoon Hospital, Pune 411001, MH, India
    J Proteomics 132:112-30. 2016
    ..a separate cohort of samples confirmed that panel of biosignatures for LB are APOA1, GELS, HS90B, EF1A1, NHRF1 and PRDX3 and for HE are PRDX1, CATD, CALR, ATPB and CH60...
  53. doi Embryonic cardiomyocytes can orchestrate various cell protective mechanisms to survive mitochondrial stress
    Manuela Magarin
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    J Mol Cell Cardiol 97:1-14. 2016
    ..Instead, the antioxidative proteins SOD2 and PRDX3 are induced, suggesting that ROS detoxification prevents oxidative damage in HCCS deficient cardiomyocytes...
  54. doi Hydrogen peroxide mediated mitochondrial UNG1-PRDX3 interaction and UNG1 degradation
    Zhilei Liu
    MOE Key Laboratory of Bioinformatics and the Center of Biomedical Analsis, School of Life Sciences, Tsinghua University, Beijing, China
    Free Radic Biol Med 99:54-62. 2016
    ..PAPSS2, CD70 antigen, and AGR2 under normal growth conditions, whereas UNG1 mainly bound to Peroxiredoxin 3 (PRDX3) via a disulfide linkage under oxidative stress...
  55. doi [The effect of fenofibrate on expression of genes involved in fatty acids beta-oxidation and associated free-radical processes]
    A P Gureev
    Voronezh State University, Voronezh, Russia
    Biomed Khim 62:426-30. 2016
    ..systems are more sensitive to elevated ROS production, as they respond by increased expression of SOD2 and PRDX3 genes, than cytoplasmic and peroxisomal antioxidant systems, where expression of CAT1, SOD1, PRDX5 genes remained ..
  56. pmc Differential expression of peroxiredoxin 3 in laryngeal squamous cell carcinoma
    Hua Zhang
    Department of Otolaryngology Head and Neck Surgery, Yuhuangding Hospital of Qingdao University, Yantai, China
    Oncotarget . 2016
    Peroxiredoxin (PRDX) proteins are involved in carcinogenesis. PRDX3, which is predominantly localized in mitochondria and up-regulated in several human cancers, seems to confer increased treatment resistance and aggressive phenotypes...
  57. ncbi Comparative analysis of a Brassica BAC clone containing several major aliphatic glucosinolate genes with its corresponding Arabidopsis sequence
    Muqiang Gao
    Departmernt of Vegetable Crops, University of California Davis, Davis, CA 95616, USA
    Genome 47:666-79. 2004
    ..The arrangement of the AOP gene family in A. thaliana is as follows: AOP3 (GS-OHP) - AOP2 (GS-ALK) - pseudogene - AOP1. In contrast, in B...
  58. ncbi The greater susceptibility of North Ronaldsay sheep compared with Cambridge sheep to copper-induced oxidative stress, mitochondrial damage and hepatic stellate cell activation
    S Haywood
    Department of Veterinary Pathology, Faculty of Veterinary Science, University of Liverpool, Liverpool L69 3BX, UK
    J Comp Pathol 133:114-27. 2005
    ..Likewise the upregulation of cathepsin-D indicated increased lysosomal activity and HSC activation. The findings may be relevant to copper toxicosis in human infants...
  59. pmc Single nucleotide polymorphisms in the PRDX3 and RPS19 and risk of HPV persistence and cervical precancer/cancer
    Mahboobeh Safaeian
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
    PLoS ONE 7:e33619. 2012
    ..Host genetic factors might affect the risk of progression from infection with carcinogenic human papillomavirus (HPV), the etiologic agent for cervical cancer, to persistent HPV infection, and hence to cervical precancer and cancer...
  60. doi Identification of proteins containing redox-sensitive thiols after PRDX1, PRDX3 and GCLC silencing and/or glucose oxidase treatment in Hepa 1-6 cells
    Carlos A Fuentes-Almagro
    Departamento de Bioquimica y Biologia Molecular, Universidad de Cordoba, Cordoba, 14071, Spain
    J Proteomics 77:262-79. 2012
    ..Nevertheless, we detected some proteins particularly sensitive to oxidation by silencing. We hypothesised that these proteins may play a role in regulatory mechanisms by redox stress...
  61. ncbi Expression of peroxiredoxin 1, 2, 3, and 6 genes in cancer cells during drug resistance formation
    E V Kalinina
    People s Friendship University of Russia, Moscow, Russia
    Bull Exp Biol Med 153:878-81. 2012
    We studied the expression of peroxiredoxin genes (PRDX1, PRDX2, PRDX3, and PRDX6) in human erythroleukemia K652, human breast carcinoma MCF-7, and human ovarian carcinoma SKOV-3 cells during cisplatin resistance development...
  62. ncbi Involvement of Prx3, a Drosophila ortholog of the thiol-dependent peroxidase PRDX3, in age-dependent oxidative stress resistance
    Yasunari Kayashima
    School of Food and Nutritional Sciences, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Japan
    Biomed Res 33:319-22. 2012
    ..We used Drosophila melanogaster to examine the function of Prx3, the Drosophila homolog of human PRDX3. The oxidative stress response in adult Drosophila is age-dependent...
  63. pmc Atox1 contains positive residues that mediate membrane association and aid subsequent copper loading
    Adrian G Flores
    Department of Molecular Biosciences and Chemistry of Life Processes Institute, Northwestern University, Evanston, IL, USA
    J Membr Biol 246:903-13. 2013
    ..Here, we demonstrate that antioxidant protein 1 (Atox1 in human cells), the principal cellular copper chaperone responsible for delivery of copper to the ..
  64. pmc A strategy for identifying transcription factor binding sites reveals two classes of genomic c-Myc target sites
    Timothy J Haggerty
    Division of Hematology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 100:5313-8. 2003
    ..significant sequence conservation of the E boxes and flanking regions, several genes (cyclin B1, JPO1, and PRDX3) belong to a second class (class II) that does not display sequence conservation at and around the site of c-Myc ..
  65. ncbi Expression of peroxiredoxins in bovine oocytes and embryos produced in vitro
    Gregory Leyens
    Veterinary Unit, Institut des Sciences de la Vie, Universite Catholique de Louvain, Place Croix du Sud 5, Louvain la Neuve, Belgium
    Mol Reprod Dev 69:243-51. 2004
    ..PRDX1 and PRDX5 transcripts were detected throughout development. PRDX2, PRDX3, and PRDX6 were not expressed around the 9- to 16-cell stage...
  66. pmc Nuclear factor E2-related factor 2 dependent overexpression of sulfiredoxin and peroxiredoxin III in human lung cancer
    Young Sun Kim
    Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine, Suwon, Korea
    Korean J Intern Med 26:304-13. 2011
    ..We aimed to elucidate the biological functions and potential roles of Srx in lung cancer...
  67. doi Detection and identification of peroxiredoxin 3 as a biomarker in hepatocellular carcinoma by a proteomic approach
    Bingbing Qiao
    Department of Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P R China
    Int J Mol Med 29:832-40. 2012
    ..01). The expression of peroxiredoxin 3 (PRDX3) at the mRNA and protein levels was confirmed by RT-PCR and western blotting in HCC cell lines, and ..
  68. doi The most negatively charged low-density lipoprotein L5 induces stress pathways in vascular endothelial cells
    Ching Yi Chen
    Department of Animal Science and Technology, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC
    J Vasc Res 49:329-41. 2012
    ..In this study, we compared the effects of LDL charge on cellular stress pathways leading to atherogenesis...
  69. doi Peroxiredoxin 1 functions as a signal peroxidase to receive, transduce, and transmit peroxide signals in mammalian cells
    Reagan M Jarvis
    Department of Biochemistry, Otago School of Medical Sciences, University of Otago, Dunedin 9054, New Zealand
    Free Radic Biol Med 53:1522-30. 2012
    ..Interestingly, in response to peroxide, Prdx1 and Prdx3 transiently formed reducible higher molecular weight complexes, suggesting that multiple proteins are targets for ..
  70. doi [MicroRNA383 regulates expression of PRDX3 in human medulloblastomas]
    Xiao Mei Wang
    Department of Pathology, Shenzhen People s Hospital the Second Affiliated Hospital, Jinan University, Shenzhen 518020, China
    Zhonghua Bing Li Xue Za Zhi 41:547-52. 2012
    To investigate the effects of microRNA-383 (miR-383) on PRDX3 gene expression, cell proliferation and apoptosis of human medulloblastma.
  71. doi Presence of autoantibody against two placental proteins, peroxiredoxin 3 and peroxiredoxin 4, in sera of recurrent pregnancy loss patients
    Behrouz Gharesi-Fard
    Department of Immunology, Shiraz University of Medical Sciences, Shiraz, Iran
    Am J Reprod Immunol 69:248-55. 2013
    ..Placenta is a pregnancy unique tissue, and proper formation of placenta is key phenomenal for success of a pregnancy. The aim of this study was to investigate the placental proteins that may act as antibody targets in RPL patients...
  72. pmc Bmal1 and β-cell clock are required for adaptation to circadian disruption, and their loss of function leads to oxidative stress-induced β-cell failure in mice
    Jeongkyung Lee
    Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    Mol Cell Biol 33:2327-38. 2013
    ..master antioxidant regulatory factor Nrf2 (nuclear factor erythroid 2-related factor 2) and its targets, Sesn2, Prdx3, Gclc, and Gclm, was decreased in β-Bmal1(-/-) islets, which may contribute to the observed increase in ROS ..
  73. pmc High-fat diet induces changes in adipose tissue trans-4-oxo-2-nonenal and trans-4-hydroxy-2-nonenal levels in a depot-specific manner
    Eric K Long
    Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA
    Free Radic Biol Med 63:390-8. 2013
    ..Moreover, TNFα treatment of 3T3-L1 adipocytes resulted in decreased expression of GSTA4, GPx4, and Prdx3 while upregulating the expression of SOD2...
  74. ncbi Antisense RNA of the latent period gene (MER5) inhibits the differentiation of murine erythroleukemia cells
    Y Nemoto
    Department of Cell Biology, Tohoku University, Sendai, Japan
    Gene 91:261-5. 1990
    The MER5 cDNA was cloned from RNA preferentially synthesized in murine erythroleukemia (MEL) cells during the early period of MEL cell differentiation...
  75. ncbi Localization of TDPX1, a human homologue of the yeast thioredoxin-dependent peroxide reductase gene (TPX), to chromosome 13q12
    P Pahl
    Eleanor Roosevelt Institute for Cancer Research, Denver, Colorado 80206, USA
    Genomics 26:602-6. 1995
    ..Oxygen radical metabolism has been hypothesized to be important for cancer, muscular dystrophy, and other disorders, so TDPX1 should be considered a candidate gene for these diseases...
  76. ncbi Cloning and characterization of OSF-3, a new member of the MER5 family, expressed in mouse osteoblastic cells
    S Kawai
    Pharma Research Laboratories, Hoechst Japan Limited, Saitama
    J Biochem 115:641-3. 1994
    ..A homology search of an amino acid sequence database revealed a strong relationship of OSF-3 to the MER5 (gene preferentially expression in murine erythroleukemia cells) protein and human pag (proliferation associated ..
  77. ncbi c-Myc selectively regulates the latent period and erythroid-specific genes in murine erythroleukemia cell differentiation
    W Shoji
    Department of Cell Biology, Tohoku University, Sendai
    Jpn J Cancer Res 84:885-92. 1993
    ..as a DNA binding transcription factor, we examined whether c-Myc regulates the latent period genes (hsp and hsc70, MER5, Id and Spi-1 genes) and the erythroid-specific genes [beta-globin, glycophorin, delta-aminolevulinic acid synthase ..
  78. ncbi Identification and mapping of Casp7, a cysteine protease resembling CPP32 beta, interleukin-1 beta converting enzyme, and CED-3
    T S Juan
    Department of Developmental Hematology, Amgen, Inc, Thousand Oaks, California 91320, USA
    Genomics 40:86-93. 1997
    ..6-kb Casp7 mRNA was expressed in various tissues except brain. Mouse interspecific backcross mapping allowed localization of Casp7 to the distal region of mouse chromosome 19, linked to Mxi1, Adra2a, and Aop1.
  79. ncbi LTW4 protein on mouse chromosome 1 is a member of a family of antioxidant proteins
    O A Iakoubova
    Genetics Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genomics 42:474-8. 1997
    ..The murine MER5 gene is also a member of this gene family and has recently been renamed Antioxidant protein 1 (Aop1), based on its functional characterization...
  80. ncbi Mitochondria of Saccharomyces cerevisiae contain one-conserved cysteine type peroxiredoxin with thioredoxin peroxidase activity
    J R Pedrajas
    Department of Biosciences at Novum, Karolinska Institute, S 141 57 Huddinge, Sweden
    J Biol Chem 275:16296-301. 2000
    ..Finally, exposure of null Prx1p mutant cells to oxidant conditions reveals an important role of the mitochondrial 1-Cys Prx in protection against oxidative stress...
  81. ncbi Interaction of human thiol-specific antioxidant protein 1 with erythrocyte plasma membrane
    M K Cha
    National Creative Research Initiatives Center for Antioxidant Proteins, Department of Biochemistry, Paichai University, Taejon 302 735, Korea
    Biochemistry 39:6944-50. 2000
    During the purification from human erythrocytes, human thiol-specific antioxidant protein 1 (hTSA1), one human member of the TSA/alkyl hydroperoxide reductase subunit C (AhpC) family, was fragmented to a molecular mass of 20 323.9300...
  82. pmc Gene duplication in the diversification of secondary metabolism: tandem 2-oxoglutarate-dependent dioxygenases control glucosinolate biosynthesis in Arabidopsis
    D J Kliebenstein
    Max Planck Institute for Chemical Ecology, 07745 Jena, Germany
    Plant Cell 13:681-93. 2001
    ..A third member of this gene family, AOP1, is present in at least two forms and found in all ecotypes examined. However, its catalytic role is still uncertain...
  83. ncbi Abrin triggers cell death by inactivating a thiol-specific antioxidant protein
    S F Shih
    Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei 10081, Taiwan, Republic of China
    J Biol Chem 276:21870-7. 2001
    ....
  84. ncbi Protein levels of human peroxiredoxin subtypes in brains of patients with Alzheimer's disease and Down syndrome
    S H Kim
    Department of Pediatrics, University of Vienna, Austria
    J Neural Transm Suppl . 2001
    ..Decreased protein levels of Prx-III could be caused by mitochondrial damage shown in AD and DS. Showing upregulated Prx protein levels provides evidence for the involvement of ROS in the pathogenesis of AD and DS...
  85. ncbi Proteomics analysis of cellular response to oxidative stress. Evidence for in vivo overoxidation of peroxiredoxins at their active site
    Thierry Rabilloud
    CEA Laboratoire de Bioénergétique Cellulaire et Pathologique, EA UJF 2943, DRDC BECP, CEA Grenoble, 17 rue des Martyrs, F 38054 Grenoble Cedex 9, France
    J Biol Chem 277:19396-401. 2002
    ....
  86. ncbi Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically
    Megumi Masaki
    Department of Biological Chemistry and CREST Core Research for Educational Science and Technology Project, Japan Science and Technology Corporation, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    Eur J Biochem 270:76-83. 2003
    ..We also provided evidence that LZK was associated directly with the IKK complex through the kinase domain, and that AOP-1 was recruited to the IKK complex through the binding to LZK...
  87. ncbi Aberrant expression of peroxiredoxin subtypes in neurodegenerative disorders
    Kurt Krapfenbauer
    F Hoffman La Roche, Basel, Switzerland
    Brain Res 967:152-60. 2003
    ..In contrast, Prx II was significantly increased (P<0.05) in frontal cortex of DS, AD and PD, whereas Prx III was decreased in frontal cortex of DS (P<0.01) and PD (P<0.001)...
  88. ncbi Effect of epoetin on HO-1 mRNA level and plasma antioxidants in hemodialysis patients
    L A Calò
    Department of Clinical and Experimental Medicine, Clinica Medica 4, University of Padova, Italy
    Int J Clin Pharmacol Ther 41:187-92. 2003
    ..Interaction of this oxidative stress with epoetin (EPO) treatment to increase RBC number and Hb concentration remains unexplored...
  89. ncbi Increased expression of mitochondrial peroxiredoxin-3 (thioredoxin peroxidase-2) protects cancer cells against hypoxia and drug-induced hydrogen peroxide-dependent apoptosis
    Larisa Nonn
    Arizona Cancer Center, University of Arizona, Tucson, AZ 85724 5024, USA
    Mol Cancer Res 1:682-9. 2003
    Peroxiredoxin-3 (Prdx3) is a mitochondrial member of the antioxidant family of thioredoxin peroxidases that uses mitochondrial thioredoxin-2 (Trx2) as a source of reducing equivalents to scavenge hydrogen peroxide (H(2)O(2))...
  90. ncbi Molecular cloning and characterization of ATX1 cDNA from the mole cricket, Gryllotalpa orientalis
    Iksoo Kim
    Department of Agricultural Biology, National Institute of Agricultural Science and Technology, RDA, Suwon, Korea
    Arch Insect Biochem Physiol 61:231-8. 2006
    To search for an insect homologue of antioxidant protein 1 (ATX1), a mole cricket, Gryllotalpa orientalis, cDNA library was screened and a cDNA clone, which encodes a 73 amino acid polypeptide with a predicted molecular mass of 8...
  91. ncbi Identification of over-expressed proteins in oral squamous cell carcinoma (OSCC) patients by clinical proteomic analysis
    Wan Yu Lo
    Department of Medical Research, China Medical University Hospital, Taichung, Taiwan
    Clin Chim Acta 376:101-7. 2007
    ..A number of protein markers for oral cancer are still not applicable in large populations. Proteomic technologies provide excellent tools for rapid screening of a large number of potential biomarkers in malignant cells...
  92. pmc Defective mitochondrial peroxiredoxin-3 results in sensitivity to oxidative stress in Fanconi anemia
    Sudit S Mukhopadhyay
    Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    J Cell Biol 175:225-35. 2006
    ..Wild-type but not G546R mutant FANCG physically interacts with the mitochondrial peroxidase peroxiredoxin-3 (PRDX3). PRDX3 is deregulated in FA cells, including cleavage by a calpainlike cysteine protease and mislocalization...
  93. ncbi Increased susceptibility of MER5 (peroxiredoxin III) knockout mice to LPS-induced oxidative stress
    Lianqin Li
    Department of Cell Biology, Institute of Development, Aging, and Cancer, Tohoku University, 4 1 Seriyo machi, Aoba ku, Sendai 980 8575, Japan
    Biochem Biophys Res Commun 355:715-21. 2007
    MER5 (also called peroxiredoxin III, PrxIII) is a member of peroxiredoxin family that has antioxidant activity. The present study was performed to investigate its in vivo function using MER5 knockout mice...
  94. ncbi Antioxidant defense in hibernation: cloning and expression of peroxiredoxins from hibernating ground squirrels, Spermophilus tridecemlineatus
    Pier Morin
    Institute of Biochemistry and Department of Chemistry, College of Natural Sciences, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada K1S 5B6
    Arch Biochem Biophys 461:59-65. 2007
    ..Comparable increases in Prdx2 were 2.4- and 3.7-fold whereas Prdx3 rose by 3.1-fold in heart of torpid animals...
  95. ncbi Proteomic approach to study the effects of various oxidatively modified low-density lipoprotein on regulation of protein expression in human umbilical vein endothelial cell
    Ching Yi Chen
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Life Sci 80:2469-80. 2007
    ..All modified LDL significantly suppressed ATP synthase, Grp58, Grp78, and Prdx3. However, the expression of hnRNP C1/C2 was significantly enhanced by FH-L5 and a-LDL; glutathione transferase was ..
  96. ncbi Mitochondrial thioredoxin-2/peroxiredoxin-3 system functions in parallel with mitochondrial GSH system in protection against oxidative stress
    Hong Zhang
    Department of Medicine, Emory University School of Medicine, Whitehead Biomedical Research Center, 615 Michael Street, Suite 205P, Atlanta, GA 30322, USA
    Arch Biochem Biophys 465:119-26. 2007
    ..The additive protection by Trx2 and GSH shows that Trx2 and GSH systems are both functionally important at low oxidative stress conditions...
  97. pmc Decreased expression of peroxiredoxins in Fuchs' endothelial dystrophy
    Ula V Jurkunas
    Schepens Eye Research Institute, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 49:2956-63. 2008
    ....
  98. doi Proteomic analysis of human articular cartilage: identification of differentially expressed proteins in knee osteoarthritis
    Dunming Guo
    Bone and Joint Surgery Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China
    Joint Bone Spine 75:439-44. 2008
    ..To better understand the pathogenesis of OA and the molecular basis of progressive destruction of articular cartilage in OA, we compared the proteome of OA cartilage with that of normal cartilage...
  99. pmc Cardiac peroxiredoxins undergo complex modifications during cardiac oxidant stress
    Ewald Schröder
    Dept of Cardiology, St Thomas Hospital, King s College London, London SE1 7EH, UK
    Am J Physiol Heart Circ Physiol 295:H425-33. 2008
    ..changes in the myocardium, including formation of disulfide bonds that were intermolecular for Prdx1, Prdx2, and Prdx3 but intramolecular within Prdx5...
  100. doi Ets regulates peroxiredoxin1 and 5 expressions through their interaction with the high-mobility group protein B1
    Masaki Shiota
    Department of Molecular Biology, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan
    Cancer Sci 99:1950-9. 2008
    ..found that both Prdx1 and Prdx5 are inducible after treatment with hydrogen peroxide or hypoxia, but that Prdx2, Prdx3, and Prdx4 are not or are only marginally inducible...
  101. pmc The effects of acrolein on peroxiredoxins, thioredoxins, and thioredoxin reductase in human bronchial epithelial cells
    Charles R Myers
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Toxicology 257:95-104. 2009
    ..The effects of acrolein on the thioredoxin system and peroxiredoxins could have important implications for cell survival, redox-sensitive cell signaling, and tolerance to other oxidant insults...

Research Grants11

  1. EPIGENETIC AGING OF THE OXIDATIVE STRESS RESPONSE IN THE MOUSE RPE
    Zeljka Smit McBride; Fiscal Year: 2010
    ..The set includes Er1, Err1, Foxo3a, Nrf2, Pgc11, Prdx3, p66/Shc1, Sirt1, Sod2, Txn2, Txnrd2, and 14-3-38...
  2. Qitao Ran; Fiscal Year: 2015
    ..and increased A[unreadable] accumulation in AD animal models and that overexpression of peroxiredoxin 3 (Prdx3), a mitochondrial antioxidant defense enzyme important for H2O2 removal, attenuated paraquat-induced cognitive ..
  3. The preventive and therapeutic potential of reducing mitochondrial H2O2 for AD
    Qitao Ran; Fiscal Year: 2011
    ..Peroxiredoxin 3 (Prdx3/Prx3) is a peroxidase specializing in scavenging H2O2 in mitochondria and is also implicated to be important for ..
  4. MYCOBACTERIAL RESISTANCE TO REACTIVE NITROGEN/OXYGEN
    Carl Nathan; Fiscal Year: 2003
    ....
  5. TARGETING DEFENSES OF MYCOBACTERIUM TUBERCULOSIS
    Carl Nathan; Fiscal Year: 2004
    ..abstract_text> ..
  6. ROLE OF NO SYNTHASE-2 IN MURINE ALZHEIMER'S DISEASE
    Carl Nathan; Fiscal Year: 2004
    ..abstract_text> ..
  7. The Center for Cancer Drug Development (C2D2)
    Stephen Howell; Fiscal Year: 2004
    ..abstract_text> ..
  8. Dihydrolipoamide Acyltransferase:Target for Chemotherapy
    Carl Nathan; Fiscal Year: 2004
    ..abstract_text> ..
  9. CISPLATIN RESISTANCE DUE TO LOSS OF DNA MISMATCH REPAIR
    Stephen Howell; Fiscal Year: 2005
    ..Thus, it is very likely that the mechanisms underlying the DDP-induced mutagenicity will be of fundamental importance to understanding the genomic instability produced by many types of cellular injury. ..
  10. MACROPHAGES, DENDRITIC CELLS AND PATHOGENS
    Carl Nathan; Fiscal Year: 2007
    ..Cores provide for BSL3 wet lab and mouse work; microarray analysis of gene expression; computation and comparison of gene expression results; and high throughput screening of chemical libraries. ..