PPP1R1B

Summary

Gene Symbol: PPP1R1B
Description: protein phosphatase 1 regulatory inhibitor subunit 1B
Alias: DARPP-32, DARPP32, protein phosphatase 1 regulatory subunit 1B, dopamine and cAMP-regulated neuronal phosphoprotein 32
Species: human

Top Publications

  1. ncbi Identification of a dopamine- and 3'5'-cyclic adenosine monophosphate-regulated phosphoprotein of 32 kD (DARPP-32) in parathyroid hormone-producing cells of the human parathyroid gland
    B Meister
    Department of Histology and Neurobiology, Karolinska Institute, Stockholm, Sweden
    J Endocrinol Invest 14:655-61. 1991
  2. ncbi The significance of L-amino acid decarboxylase and DARPP-32 in the kidney
    A Aperia
    Department of Pediatrics, , Stockholm, Sweden
    Am J Hypertens 3:11S-13S. 1990
  3. ncbi Gastric cancers overexpress DARPP-32 and a novel isoform, t-DARPP
    Wa el El-Rifai
    Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908 0708, USA
    Cancer Res 62:4061-4. 2002
  4. ncbi Darpp-32: a novel antiapoptotic gene in upper gastrointestinal carcinomas
    Abbes Belkhiri
    Digestive Health Center of Excellence and Department of Pathology, University of Virginia Health System, Charlottesville, Virginia 22908 0708, USA
    Cancer Res 65:6583-92. 2005
  5. doi Dopamine D1 receptor-dependent modifications in the dopamine and cAMP-regulated phosphoprotein of Mr 32 kDa phosphorylation pattern in striatal areas of morphine-sensitized rats
    S Scheggi
    Department of Neuroscience, Pharmacology Unit, University of Siena, Italy
    Neuroscience 163:627-39. 2009
  6. pmc Characterization of the interaction between DARPP-32 and protein phosphatase 1 (PP-1): DARPP-32 peptides antagonize the interaction of PP-1 with binding proteins
    Y G Kwon
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 94:3536-41. 1997
  7. ncbi Functional dopamine-1 receptors and DARPP-32 are expressed in human ovary and granulosa luteal cells in vitro
    A Mayerhofer
    Anatomisches Institut der Technischen Universität München, Germany
    J Clin Endocrinol Metab 84:257-64. 1999
  8. ncbi D1-Receptor, DARPP-32, and PP-1 in the primate corpus luteum and luteinized granulosa cells: evidence for phosphorylation of DARPP-32 by dopamine and human chorionic gonadotropin
    A Mayerhofer
    Anatomisches Institut, Universitat Munchen, D 80802 München, Germany
    J Clin Endocrinol Metab 85:4750-7. 2000
  9. ncbi Proteomic characterization of protein phosphatase 1 complexes in ischemia-reperfusion and ischemic tolerance
    Cristina Cid
    Department of Investigation, Hospital Ramon y Cajal, Madrid, Spain
    Proteomics 7:3207-18. 2007
  10. pmc Detailed structural characterization of unbound protein phosphatase 1 inhibitors
    Barbara Dancheck
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, Rhode Island 02912, USA
    Biochemistry 47:12346-56. 2008

Research Grants

  1. GENETIC ABBERATIONS IN HPRT DEFICIENCY
    Theodore Friedmann; Fiscal Year: 2007
  2. Laurie J Ozelius; Fiscal Year: 2016
  3. RAYMOND CHARLES KOEHLER; Fiscal Year: 2016
  4. Dopamine Signaling Mechanisms of Traumatic Brain Injury
    C Edward Dixon; Fiscal Year: 2013
  5. Regulation of striatal cannabinoid CB1 receptors by DARPP32 and deltaFosB mediate
    Matthew F Lazenka; Fiscal Year: 2012
  6. COCAINE AND BRAIN DEVELOPMENT
    Pradeep G Bhide; Fiscal Year: 2010
  7. The Role of Tissue Plasminogen Activator in a Mouse Spinal Cord Injury Model
    Noreen Bukhari; Fiscal Year: 2012
  8. Structure-function of inositol trisphosphate receptor
    Ilya Bezprozvanny; Fiscal Year: 2009
  9. RECEPTORS MEDIATING DRUG DEPENDENCE
    Susan R George; Fiscal Year: 2013
  10. WENDY JEAN LYNCH; Fiscal Year: 2016

Detail Information

Publications195 found, 100 shown here

  1. ncbi Identification of a dopamine- and 3'5'-cyclic adenosine monophosphate-regulated phosphoprotein of 32 kD (DARPP-32) in parathyroid hormone-producing cells of the human parathyroid gland
    B Meister
    Department of Histology and Neurobiology, Karolinska Institute, Stockholm, Sweden
    J Endocrinol Invest 14:655-61. 1991
    ..The present results suggest that DARPP-32 may play a role in the cellular mechanisms leading to dopamine-induced PTH secretion...
  2. ncbi The significance of L-amino acid decarboxylase and DARPP-32 in the kidney
    A Aperia
    Department of Pediatrics, , Stockholm, Sweden
    Am J Hypertens 3:11S-13S. 1990
    ..The effect involves activation of cAMP protein kinase. It is likely that this effect is potentiated by DARPP-32...
  3. ncbi Gastric cancers overexpress DARPP-32 and a novel isoform, t-DARPP
    Wa el El-Rifai
    Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908 0708, USA
    Cancer Res 62:4061-4. 2002
    ..Our results reveal for the first time the presence of these signaling molecules in human cancer and suggest that they may be important for gastric tumorigenesis...
  4. ncbi Darpp-32: a novel antiapoptotic gene in upper gastrointestinal carcinomas
    Abbes Belkhiri
    Digestive Health Center of Excellence and Department of Pathology, University of Virginia Health System, Charlottesville, Virginia 22908 0708, USA
    Cancer Res 65:6583-92. 2005
    ..The expression of Darpp-32 and t-Darpp is associated with a potent antiapoptotic advantage for cancer cells through a p53-independent mechanism that involves preservation of mitochondrial potential and increased Bcl2 levels...
  5. doi Dopamine D1 receptor-dependent modifications in the dopamine and cAMP-regulated phosphoprotein of Mr 32 kDa phosphorylation pattern in striatal areas of morphine-sensitized rats
    S Scheggi
    Department of Neuroscience, Pharmacology Unit, University of Siena, Italy
    Neuroscience 163:627-39. 2009
    ..Since DARPP-32 phosphorylated in Thr75 inhibits cAMP-dependent protein kinase (PKA) activity, the final result is a decrease in the dopamine D(1) receptor-dependent phosphorylation events...
  6. pmc Characterization of the interaction between DARPP-32 and protein phosphatase 1 (PP-1): DARPP-32 peptides antagonize the interaction of PP-1 with binding proteins
    Y G Kwon
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 94:3536-41. 1997
    ....
  7. ncbi Functional dopamine-1 receptors and DARPP-32 are expressed in human ovary and granulosa luteal cells in vitro
    A Mayerhofer
    Anatomisches Institut der Technischen Universität München, Germany
    J Clin Endocrinol Metab 84:257-64. 1999
    ..Taken together, the presence of DA and a functional DA receptor and DARPP-32 indicate that a novel, physiological regulatory pathway involving DA exists in the human ovary...
  8. ncbi D1-Receptor, DARPP-32, and PP-1 in the primate corpus luteum and luteinized granulosa cells: evidence for phosphorylation of DARPP-32 by dopamine and human chorionic gonadotropin
    A Mayerhofer
    Anatomisches Institut, Universitat Munchen, D 80802 München, Germany
    J Clin Endocrinol Metab 85:4750-7. 2000
    ..The PP-1 inhibitor DARPP-32 may, thus, be a third messenger used by both DA and hCG/LH to exert common regulatory influences on the cells of the CL...
  9. ncbi Proteomic characterization of protein phosphatase 1 complexes in ischemia-reperfusion and ischemic tolerance
    Cristina Cid
    Department of Investigation, Hospital Ramon y Cajal, Madrid, Spain
    Proteomics 7:3207-18. 2007
    ..of heat shock cognate 71 kDa-protein, creatine kinase B, and dopamine- and cAMP-regulated phosphoprotein 32 kDa (DARPP32) with both PP1alpha and PP1gamma, and the interaction of phosphodiesterase-6B, transitional ER ATPase, lamin-A, ..
  10. pmc Detailed structural characterization of unbound protein phosphatase 1 inhibitors
    Barbara Dancheck
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, Rhode Island 02912, USA
    Biochemistry 47:12346-56. 2008
    ..Together, these interactions enable potent and selective inhibition of PP1...
  11. ncbi DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1
    H C Hemmings
    Nature 310:503-5. 1984
    ..Thus, the basal ganglia of mammalian brain contain a region-specific neuronal phosphoprotein that is a protein phosphatase inhibitor...
  12. ncbi DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. I. Regional and cellular distribution in the rat brain
    S I Walaas
    J Neurosci 4:84-98. 1984
    ..W. Aswad, and P. Greengard (1984) J. Neurosci. 4: 99-110) and the immunocytochemical localization of this phosphoprotein (Ouimet, C.C., P. Miller, H.C. Hemmings, Jr., S.I. Walaas, and P. Greengard (1984) J. Neurosci. 4: 111-124)...
  13. ncbi Expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in human brain tissue
    S Brene
    Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
    J Neurosci 14:985-98. 1994
    ....
  14. ncbi Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons
    J A Bibb
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021, USA
    Nature 402:669-71. 1999
    ..Thus DARPP-32 is a bifunctional signal transduction molecule which, by distinct mechanisms, controls a serine/threonine kinase and a serine/threonine phosphatase...
  15. ncbi Overexpression of the 32-kilodalton dopamine and cyclic adenosine 3',5'-monophosphate-regulated phosphoprotein in common adenocarcinomas
    Andy Beckler
    Department of Medicine, Division of Gastroenterology, University of Virginia Health System, Charlottesville, Virginia 22908 0708, USA
    Cancer 98:1547-51. 2003
    ..Recently, DARPP-32 and a truncated isoform, t-DARPP, have been cloned in gastric carcinoma. The extent of DARPP-32 and t-DARPP expression in human epithelial tissues and carcinomas remained unknown...
  16. ncbi Coamplified and overexpressed genes at ERBB2 locus in gastric cancer
    Asta Varis
    Departments of Pathology and Medical Genetics, Haartman Institute, University of Helsinki and Helsinki University Central Hospital Laboratory Diagnostics, Helsinki, Finland
    Int J Cancer 109:548-53. 2004
    ..amplicon formation because this region harbors the ERBB2 oncogene and several other targets, such as TOP2A and DARPP32. In our study, we characterized the amplification (52 cases) and expression (29 cases) levels of ERBB2, TOP2A and ..
  17. pmc DARPP-32 expression arises after a phase of dysplasia in oesophageal squamous cell carcinoma
    Y Ebihara
    Surgical Oncology, Cancer Medicine, Division of Cancer Medicine, Hokkaido University Graduate School of Medicine, N15W7 Kita ku, Sapporo, Hokkaido 060 8638, Japan
    Br J Cancer 91:119-23. 2004
    ..These observations suggest that DARPP-32 (rather than t-DARPP) expression arises after a phase of dysplasia in OSCC, and that tumours expressing DARPP-32 progress less rapidly than DARPP-32-negative tumours...
  18. pmc Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognition
    Andreas Meyer-Lindenberg
    Unit for Systems Neuroscience in Psychiatry, Neuroimaging Core Facility, and Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute for Mental Health NIMH, NIH, Bethesda, MD 20892, USA
    J Clin Invest 117:672-82. 2007
    Dopamine- and cAMP-regulated phosphoprotein of molecular weight 32 kDa (DARPP-32), encoded by PPP1R1B, is a pivotal integrator of information in dopaminoceptive neurons, regulating the response to neuroleptics, psychotomimetics, and ..
  19. ncbi Immunohistochemical and immunoblot analysis of Dopamine and cyclic AMP-regulated phosphoprotein, relative molecular mass 32,000 (DARPP-32) in the prefrontal cortex of subjects with schizophrenia and bipolar disorder
    Masanori Ishikawa
    Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba City, Ibaraki 305 8575, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 31:1177-81. 2007
    ....
  20. doi t-Darpp promotes cancer cell survival by up-regulation of Bcl2 through Akt-dependent mechanism
    Abbes Belkhiri
    Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Cancer Res 68:395-403. 2008
    ..In conclusion, the t-Darpp/Akt axis underscores a novel oncogenic potential of t-Darpp in gastric carcinogenesis and resistance to drug-induced apoptosis...
  21. pmc Expression of t-DARPP mediates trastuzumab resistance in breast cancer cells
    Abbes Belkhiri
    Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Clin Cancer Res 14:4564-71. 2008
    ..We have investigated the role of t-DARPP in trastuzumab resistance in ERBB2-amplified and overexpressed breast cancer cell lines...
  22. ncbi Anti-DARPP32 antibody-immunopositive inclusions in the brain of patients with multiple system atrophy
    Y Honjo
    Department of Neurology, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Clin Neuropathol 27:309-16. 2008
    ..Among these substrates, tau and MAP 1B are immunopositive in GCIs. DARPP32 has been identified as a target for dopamine and PKA in the striatum...
  23. doi Replication study of candidate genes for cognitive abilities: the Lothian Birth Cohort 1936
    L M Houlihan
    Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK
    Genes Brain Behav 8:238-47. 2009
    ..The genes include BDNF, COMT, DISC1, KL, NCSTN, PPP1R1B, PRNP, SHANK3, SORL1 and WRN...
  24. doi Both t-Darpp and DARPP-32 can cause resistance to trastuzumab in breast cancer cells and are frequently expressed in primary breast cancers
    Sophie Hamel
    Department of Oncology and Surgery, Segal Cancer Center, Sir Mortimer B Davis Jewish General Hospital, 3755 Cote Ste Catherine, Montreal, QC, H3T 1E2, Canada
    Breast Cancer Res Treat 120:47-57. 2010
    ..The most overexpressed gene in these subclones was PPP1R1B, encoding the DARPP-32 phosphatase inhibitor...
  25. pmc Wnt-5a-induced phosphorylation of DARPP-32 inhibits breast cancer cell migration in a CREB-dependent manner
    Christian Hansen
    Experimental Pathology, Department of Laboratory Medicine, Lund University, CRC, 205 02 Malmo, Sweden
    J Biol Chem 284:27533-43. 2009
    ....
  26. pmc t-DARPP regulates phosphatidylinositol-3-kinase-dependent cell growth in breast cancer
    Bhavatarini Vangamudi
    Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Mol Cancer 9:240. 2010
    ..In this study, we evaluated expression of t-DARPP in human primary breast tumors, and investigated the role of t-DARPP in regulating growth and proliferation in breast cancer cells...
  27. pmc Infusions of anti-sense oligonucleotides for DARPP-32 to the ventral tegmental area reduce effects of progesterone- and a dopamine type 1-like receptor agonist to facilitate lordosis
    Cheryl A Frye
    Department of Psychology, The University at Albany State University of New York, Albany, NY 12222, United States
    Behav Brain Res 206:286-92. 2010
    ..Together, these findings suggest that, in the midbrain VTA, P4's actions to facilitate sexual behavior of female rodents, involving D1 receptors, may require DARPP-32...
  28. pmc Histone H3 phosphorylation is under the opposite tonic control of dopamine D2 and adenosine A2A receptors in striatopallidal neurons
    Jesus Bertran-Gonzalez
    INSERM, UMR S 839, Paris, France
    Neuropsychopharmacology 34:1710-20. 2009
    ..Thus, blockade of D2Rs promotes histone H3 phosphorylation through the A2AR-mediated activation of Galpha(olf) and inhibition of protein phosphatase-1 (PP-1) through the PKA-dependent phosphorylation of DARPP-32...
  29. ncbi Expression of D1 but not D2 dopamine receptors in striatal neurons producing neurokinin B in rats
    Takahiro Sonomura
    Department of Anatomy for Oral Sciences, Graduate School of Medical and Dental Sciences, Advanced Therapeutic Course, Field of Neurology, Kagoshima University, Kagoshima 890 8544, Japan
    Eur J Neurosci 26:3093-103. 2007
    ....
  30. pmc Evaluation of neuronal phosphoproteins as effectors of caffeine and mediators of striatal adenosine A2A receptor signaling
    Bogachan Sahin
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Brain Res 1129:1-14. 2007
    ..Finally, the phosphorylation state of these proteins was further assessed in vivo by systemic administration of caffeine...
  31. pmc Nerve agent exposure elicits site-specific changes in protein phosphorylation in mouse brain
    Hongwen Zhu
    Department of Molecular Neuropharmacology, Intra Cellular Therapies, Inc ITI, Audubon Business and Technology Center, 3960 Broadway, New York, NY 10032, USA
    Brain Res 1342:11-23. 2010
    ..This approach identifies specific targets for nerve agents, including substrates for Cdk5 kinase, which may be the basis for new anti-convulsant therapies...
  32. pmc Dopamine receptor modulation of hypoxic-ischemic neuronal injury in striatum of newborn piglets
    Zeng Jin Yang
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Cereb Blood Flow Metab 27:1339-51. 2007
    ..Furthermore, mechanisms of D1 receptor toxicity may involve DARPP-32-dependent phosphorylation of NMDA receptor NR1 and Na(+),K(+)-ATPase...
  33. doi Synergistic interactions of dopamine D1 and glutamate NMDA receptors in rat hippocampus and prefrontal cortex: involvement of ERK1/2 signaling
    K Sarantis
    Physiology Department, Medical School, University of Patras, Rio, Patras, Greece
    Neuroscience 163:1135-45. 2009
    ....
  34. ncbi Organization of the avian basal forebrain: chemical anatomy in the parrot (Melopsittacus undulatus)
    Todd Freeman Roberts
    Department of Psychology, University of Maryland, College Park, Maryland 20742, USA
    J Comp Neurol 454:383-408. 2002
    ..The budgerigar septal region is theorized to be homologous as a field to the mammalian septum. Our results are discussed with regard to both the evolution of the basal forebrain and its role in vocal learning processes...
  35. ncbi Anatomical markers for the subdivisions of the barn owl's inferior-collicular complex and adjacent peri- and subventricular structures
    Hermann Wagner
    Institut fur Biologie II, Rheinisch Westfaelishe Technische Hochschule Aachen, D 52074 Aachen, Germany
    J Comp Neurol 465:145-59. 2003
    ..None of the markers delineated the border between the medial and lateral shell of ICC...
  36. pmc A role for casein kinase 1 epsilon in the locomotor stimulant response to methamphetamine
    Camron D Bryant
    Department of Human Genetics, University of Chicago, 920 E 58th St CLSC 507D, Chicago, IL 60637, USA
    Psychopharmacology (Berl) 203:703-11. 2009
    ..Based on these results, we hypothesized that differential expression of Csnk1-epsilon causes differential sensitivity to MA-induced locomotor activity in mice...
  37. ncbi Neuropathological and behavioral changes induced by various treatment paradigms with MPTP and 3-nitropropionic acid in mice: towards a model of striatonigral degeneration (multiple system atrophy)
    Nadia Stefanova
    Department of Neurology, University Hospital of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Acta Neuropathol 106:157-66. 2003
    ..This suggests that complex integrative mechanisms are likely to regulate the vulnerability of the striatum and SNc to cell death in SND/MSA-P...
  38. ncbi Cooperation between D1- and D2-dopamine receptors in the nucleus accumbens
    A Szmigielski
    Department of Pharmacodynamics, Medical Academy, Lodz, Poland
    Neuropharmacology 30:259-66. 1991
    ..The results suggest that D1 and D2 receptors in the nucleus accumbens could cooperate with the same adenylate cyclase and could be located on the same neurones...
  39. ncbi A Theileria parva type 1 protein phosphatase activity
    X Cayla
    Laboratoire de Physiologie de la Reproduction, INRA CNRS ESA 7080, 9 quai Saint Bernard, 75005, Paris, France
    Mol Biochem Parasitol 110:161-6. 2000
    ..Intriguingly, since type 1 OA-sensitive phosphatase activity has been recently described in Plasmodium falciparum, we can conclude that these medically important parasites produce their one PP1...
  40. ncbi General anesthetics selectively modulate glutamatergic and dopaminergic signaling via site-specific phosphorylation in vivo
    Gretchen L Snyder
    Department of Neuropharmacology, Intra Cellular Therapies, Inc ITI, Audubon Business and Technology Center, 3960 Broadway, New York, NY 10032, USA
    Neuropharmacology 53:619-30. 2007
    ..This novel approach indicates a role for phosphorylation-mediated down-regulation of glutamatergic synaptic transmission by general anesthetics and identifies specific in vivo targets for focused evaluation of anesthetic mechanisms...
  41. ncbi RARbeta isoform-specific regulation of DARPP-32 gene expression: an ectopic expression study in the developing rat telencephalon
    Wen Lin Liao
    Institute of Neuroscience, National Yang Ming University, 155 Li Rum Street, Taipei 11211, Taiwan
    Eur J Neurosci 21:3262-8. 2005
    ..The molecular diversity of RARbeta isoforms may underlie parts of the complex gene regulation by retinoids during neural development...
  42. pmc Regulation of cyclin-dependent kinase 5 and casein kinase 1 by metabotropic glutamate receptors
    F Liu
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 98:11062-8. 2001
    ..Together these results indicate that a CK1-Cdk5-DARPP-32 cascade may be involved in the regulation by mGluR agonists of Ca(2+) channels...
  43. doi Caffeine and a selective adenosine A2A receptor antagonist induce reward and sensitization behavior associated with increased phospho-Thr75-DARPP-32 in mice
    Chih W Hsu
    Department of Emergency Medicine, Tzu Chi General Hospital, Hualien 970, Taiwan
    Psychopharmacology (Berl) 204:313-25. 2009
    ....
  44. ncbi Immunohistochemical localization of DARPP-32 in the brain of the lizard, Gekko gecko: co-occurrence with tyrosine hydroxylase
    W J Smeets
    The Graduate School of Neurosciences Amsterdam, Research Institute of Neurosciences and Department of Anatomy, Vrije Universiteit, Amsterdam, The Netherlands
    J Comp Neurol 435:194-210. 2001
    ....
  45. ncbi Immunohistochemical localization of DARPP-32 in the brain of the turtle, Pseudemys scripta elegans: further assessment of its relationship with dopaminergic systems in reptiles
    Wilhelmus J A J Smeets
    Department of Anatomy, The Graduate School of Neurosciences Amsterdam, Research Institute of Neurosciences, Vrije Universiteit Medisch Centrum, Van der Boechorststraat 7, BT 1081 Amsterdam, The Netherlands
    J Chem Neuroanat 25:83-95. 2003
    ..At the same time, however, it demonstrates that substantial species differences exist, some of which may be related to differences previously observed in the dopaminergic systems...
  46. ncbi The homeobox gene Gsh2 is required for retinoid production in the embryonic mouse telencephalon
    Ronald R Waclaw
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Development 131:4013-20. 2004
    ..Thus, in addition to the previously described role for Gsh2 to maintain correct molecular identity in the LGE, our results demonstrate a novel requirement of this gene for retinoid production within the ventral telencephalon...
  47. pmc The B''/PR72 subunit mediates Ca2+-dependent dephosphorylation of DARPP-32 by protein phosphatase 2A
    Jung Hyuck Ahn
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 104:9876-81. 2007
    ..In addition, our studies reveal an alternative intracellular mechanism whereby Ca(2+) can activate serine/threonine phosphatase activity...
  48. doi Blockade of adenosine A2A receptors downregulates DARPP-32 but increases ERK1/2 activity in striatum of dopamine deficient "weaver" mouse
    Konstantinos Botsakis
    Laboratory of Human and Animal Physiology, Department of Biology, University of Patras, Patras, Greece
    Neurochem Int 56:245-9. 2010
    ..e. in "weaver" animals A(2A) receptor blockade increases the activity of ERK1/2 cascade. This could be of clinical relevance since A(2A) antagonists are already used in clinical trials for ameliorating Parkinson's disease (PD) symptoms...
  49. pmc Differential fate and functional outcome of lithium chloride primed adult neural progenitor cell transplants in a rat model of Huntington disease
    Elena M Vazey
    Department of Pharmacology and Clinical Pharmacology, Centre for Brain Research, Faculty of Medical Health Sciences, The University of Auckland, Private Bag 92019, Auckland Mail Centre, Auckland 1142, New Zealand
    Stem Cell Res Ther 1:41. 2010
    ....
  50. pmc Glutamate regulation of DARPP-32 phosphorylation in neostriatal neurons involves activation of multiple signaling cascades
    Akinori Nishi
    Department of Pharmacology, Kurume University School of Medicine, Kurume, Fukuoka 830 0011, Japan
    Proc Natl Acad Sci U S A 102:1199-204. 2005
    ....
  51. ncbi Nucleus accumbens subregions: hodological and immunohistochemical study in the domestic chick (Gallus domesticus)
    Eszter Bálint
    Department of Anatomy, Semmelweis University, 58 Tuzolto utca, H 1450, Budapest, Hungary
    Cell Tissue Res 327:221-30. 2007
    ..6 into a putative shell and core by the methods employed in the present study. This region probably corresponds to the rostral pole of the nucleus accumbens...
  52. ncbi The importance of A9 dopaminergic neurons in mediating the functional benefits of fetal ventral mesencephalon transplants and levodopa-induced dyskinesias
    Wei Li Kuan
    Cambridge Centre for Brain Repair, Forvie Site, Robinson Way, Cambridge CB2 2PY, UK
    Neurobiol Dis 25:594-608. 2007
    ..These results suggest that an A9 dopaminergic neuron-enriched transplant may be the key to an effective PD cell replacement therapy through normalisation of the altered striatal expression of Cdk5/DARPP-32...
  53. pmc The internal state of medium spiny neurons varies in response to different input signals
    Zhen Qi
    Department of Biomedical Engineering, Georgia Institute of Technology and Emory University Medical School, Atlanta, GA 30332, USA
    BMC Syst Biol 4:26. 2010
    ..DARPP-32's unique capacity of faithfully converting distinct neurotransmitter signals into appropriate responses is achieved through a complex phosphorylation-dephosphorylation system that evades intuition and predictability...
  54. pmc Distinct changes in cAMP and extracellular signal-regulated protein kinase signalling in L-DOPA-induced dyskinesia
    Emanuela Santini
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 5:e12322. 2010
    ..However, very little is known, in non-human primates, about the regulation of these signalling cascades and their association with the induction, manifestation and/or maintenance of dyskinesia...
  55. ncbi DARPP-32 knockout mice exhibit impaired reversal learning in a discriminated operant task
    C J Heyser
    Department of Psychology, Franklin and Marshall College, P O Box 3003, Lancaster, PA 17604, USA
    Brain Res 867:122-30. 2000
    ..These results provide evidence for a functional role of DARPP-32 in the mediation of processes underlying learning and memory...
  56. ncbi In vivo magnetic resonance imaging of embryonic neural grafts in a rat model of striatonigral degeneration (multiple system atrophy)
    M F Schocke
    Department of Magnetic Resonance Imaging and Spectroscopy, Department of Neurology, Department of Anaesthesia, The Leopold Franzens University of Innsbruck, Anichstrasse 35, Innsbruck, 6020, Austria
    Neuroimage 12:209-18. 2000
    ..5 Tesla MRI scanner. Additionally, we obtained an excellent correlation between MRI and histological measurements...
  57. ncbi Phenotypic studies on dopamine receptor subtype and associated signal transduction mutants: insights and challenges from 10 years at the psychopharmacology-molecular biology interface
    John L Waddington
    Institute of Biopharmaceutical Sciences, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    Psychopharmacology (Berl) 181:611-38. 2005
    ..Furthermore, there are poorly understood methodological factors that contribute to inconsistent phenotypic findings between laboratories...
  58. ncbi Gene expression differences in mice divergently selected for methamphetamine sensitivity
    Abraham A Palmer
    Columbia Genome Center, Columbia University, 1150 St Nicholas Ave, New York, New York 10032, USA
    Mamm Genome 16:291-305. 2005
    ..The identified genes provide excellent candidates for future hypothesis-driven studies, translational genetic studies, and pharmacological interventions...
  59. ncbi Association between the casein kinase 1 epsilon gene region and subjective response to D-amphetamine
    Jeremy Veenstra-Vanderweele
    Institute of Juvenile Research, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60637, USA
    Neuropsychopharmacology 31:1056-63. 2006
    ..001), which corresponded to a leftward shift in the dose-response curve. These findings demonstrate the successful translation of pharmacogenetic results from mice to humans...
  60. doi Protein components of the blood-brain barrier (BBB) in the brainstem area postrema-nucleus tractus solitarius region
    Nasren Maolood
    Department of Neuroscience, The Retzius Laboratory, Retzius vag 8, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    J Chem Neuroanat 37:182-95. 2009
    ..Such vessels may represent a route of entry for circulating substances to neurons in the NTS that inter alia regulate energy balance...
  61. pmc D(2) dopamine receptors induce mitogen-activated protein kinase and cAMP response element-binding protein phosphorylation in neurons
    Z Yan
    Laboratory of Molecular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 96:11607-12. 1999
    ..Our results suggest that MAPK and CREB signaling cascades are involved in the regulation of gene expression and other long-term effects of D(2) receptor activation...
  62. ncbi Genetic conservation of the immunophilin-binding domains of human calcineurin A1 and A2
    I J Brogan
    Immunology Research Group, School of Biological Sciences, University of Manchester, UK
    Transpl Immunol 8:139-41. 2000
    ..These results suggest that this region is highly conserved and cannot account for individual variation in response of patients to FK506 and CsA treatment...
  63. ncbi Chronic systemic complex I inhibition induces a hypokinetic multisystem degeneration in rats
    Günter U Höglinger
    INSERM U 289, Experimental Neurology and Therapeutics, Hopital de la Salpetriere, Paris, France
    J Neurochem 84:491-502. 2003
    ....
  64. ncbi Immunohistochemical localization of DARPP32 in striatal projection neurons and striatal interneurons in pigeons
    A Reiner
    Department of Anatomy and Neurobiology, The University of Tennessee Memphis, The Health Science Center, 38163, USA
    J Chem Neuroanat 16:17-33. 1998
    b>DARPP32 is a D1-receptor associated signaling protein found in striatal projection neurons in mammals, including both substance P-containing (SP+) neurons and enkephalinergic (ENK+) projection neurons...
  65. ncbi The role of the cannabinoid type 1 receptor and down-stream cAMP/DARPP-32 signal in the nucleus accumbens of methamphetamine-sensitized rats
    Yao Chang Chiang
    Laboratory of Neuropharmacology, Department of Physiology and Pharmacology, Chang Gung University and Molecular Imaging Center, Chang Gung Hospital, Kwei Shan, Tao Yuan, Taiwan, Republic of China
    J Neurochem 103:2505-17. 2007
    ..Overall, we demonstrated that brain CB(1) receptor and its down-stream cAMP/DARPP-32/T34/PP-2B signaling are profoundly altered in methamphetamine-sensitized animals...
  66. doi PKA-mediated responses in females' estrous cycle affect cocaine-induced responses in dopamine-mediated intracellular cascades
    J Weiner
    Doctoral Subprogram in Biopsychology and Behavioral Neuroscience, City University of New York, New York, NY 10065, USA
    Neuroscience 161:865-76. 2009
    ..Taken together, these novel findings suggest that hormonal fluctuations during the estrous cycle may contribute to the previously reported sex differences in the PKA pathway and in behavioral responses to cocaine...
  67. ncbi Localization of dopamine D1 receptors and dopaminoceptive neurons in the chick forebrain
    R Schnabel
    Federal Institute for Neurobiology, Magdeburg, Germany
    J Comp Neurol 388:146-68. 1997
    ..These results indicate that DARPP-32 as well as D1 receptors in the avian forebrain reveal a distribution that is substantially similar to that of mammals...
  68. ncbi Ethologically based resolution of D2-like dopamine receptor agonist-versus antagonist-induced behavioral topography in dopamine- and adenosine 3',5'-monophosphate-regulated phosphoprotein of 32 kDa "knockout" mutants congenic on the C57BL/6 gene
    Rachel E Nally
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    J Pharmacol Exp Ther 310:1281-7. 2004
    ..Critically, the present data indicate that phenotypic effects of a given gene deletion using an agonist acting on the system disrupted cannot be generalized to a corresponding antagonist, and vice versa...
  69. ncbi Paradoxical striatal cellular signaling responses to psychostimulants in hyperactive mice
    Jean Martin Beaulieu
    Department of Cell Biology, Duke University Medical Center, Research Drive, Durham, NC 27710, USA
    J Biol Chem 281:32072-80. 2006
    ....
  70. pmc Cell type-specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugs
    Helen S Bateup
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Ave, New York, New York 10065, USA
    Nat Neurosci 11:932-9. 2008
    ..Furthermore, we found that a variety of drugs that target the striatum have cell type-specific effects that previous methods were not able to discern...
  71. doi The proline-rich N-terminal sequence of calcineurin Abeta determines substrate binding
    Susann Kilka
    Max Planck Research Unit for Enzymology of Protein Folding, Weinbergweg 22, D 06120 Halle Saale, Germany
    Biochemistry 48:1900-10. 2009
    ....
  72. pmc Abnormal social behavior, hyperactivity, impaired remote spatial memory, and increased D1-mediated dopaminergic signaling in neuronal nitric oxide synthase knockout mice
    Koichi Tanda
    Genetic Engineering and Functional Genomics Group, Horizontal Medical Research Organization, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Mol Brain 2:19. 2009
    ..We also examined the role of nNOS in dopamine/DARPP-32 signaling in striatal slices from nNOS KO mice and the effects of the administration of a dopamine D1 receptor agonist on behavior in nNOS KO mice...
  73. pmc Developmental exposure to manganese increases adult susceptibility to inflammatory activation of glia and neuronal protein nitration
    Julie A Moreno
    Center for Environmental Medicine, Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    Toxicol Sci 112:405-15. 2009
    ..These data indicate that subchronic exposure to Mn during development leads to temporally distinct patterns of glial activation that result in elevated nitrosative stress in distinct populations of basal ganglia neurons...
  74. pmc Incubation of nicotine seeking is associated with enhanced protein kinase A-regulated signaling of dopamine- and cAMP-regulated phosphoprotein of 32 kDa in the insular cortex
    Amir Abdolahi
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, 1670 Discovery Drive, Charlottesville, VA 22911, USA
    Eur J Neurosci 31:733-41. 2010
    ....
  75. doi GABAergic neurons from mouse embryonic stem cells possess functional properties of striatal neurons in vitro, and develop into striatal neurons in vivo in a mouse model of Huntington's disease
    Eunju Shin
    Institute for Science and Technology in Medicine, Keele University, Keele ST5 5BG, UK
    Stem Cell Rev 8:513-31. 2012
    ..method-derived GABAergic neurons expressed the MSN marker dopamine- and cyclic AMP-regulated phosphoprotein (DARPP32)...
  76. pmc Relation of addiction genes to hypothalamic gene changes subserving genesis and gratification of a classic instinct, sodium appetite
    WOLFGANG B LIEDTKE
    Department of Medicine, Duke University, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 108:12509-14. 2011
    ..Our findings outline a molecular logic for instinctive behavior encoded by the brain with possible important translational-medical implications...
  77. pmc Candidate gene-based association study of antipsychotic-induced movement disorders in long-stay psychiatric patients: a prospective study
    P Roberto Bakker
    Psychiatric Centre GGZ Centraal, Amersfoort, The Netherlands
    PLoS ONE 7:e36561. 2012
    ..and bradykinesia), as well as a principal-factor of the movement disorders and their subtypes, were examined for association with variation in 10 candidate genes (PPP1R1B, BDNF, DRD3, DRD2, HTR2A, HTR2C, COMT, MnSOD, CYP1A2, and RGS2).
  78. doi Proteomic analysis of alterations induced by perinatal hypoxic-ischemic brain injury
    Katja Rosenkranz
    Department of Functional Proteomics, Ruhr University Bochum, Germany
    J Proteome Res 11:5794-803. 2012
    ..Active forms of Calcineurin are associated with the dephosphorylation of Darpp-32, an effect that was also demonstrated in lesioned hemispheres after perinatal brain injury...
  79. pmc ERK regulation of phosphodiesterase 4 enhances dopamine-stimulated AMPA receptor membrane insertion
    Roy S Song
    Departments of Pharmacology and Systems Therapeutics, Friedman Brain Institute, and System Biology Center NY, Icahn School of Medicine at Mount Sinai, New York, NY 10029
    Proc Natl Acad Sci U S A 110:15437-42. 2013
    ..The combination of dynamical models and experiments has helped us unravel the complex interactions between two protein kinase pathways in regulating a fundamental molecular process underlying synaptic plasticity. ..
  80. ncbi Rat DARPP-32: cloning, sequencing, and characterization of the cDNA
    M E Ehrlich
    Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, New York 10021
    J Mol Neurosci 2:1-10. 1990
    ..Unilateral destruction of the nigrostriatal dopaminergic pathway by injection of 6-hydroxydopamine (6-OHDA) into the substantia nigra did not alter the striatal steady state levels of DARPP-32 mRNA...
  81. ncbi Phosphodiesterase 1B knock-out mice exhibit exaggerated locomotor hyperactivity and DARPP-32 phosphorylation in response to dopamine agonists and display impaired spatial learning
    Tracy M Reed
    Division of Developmental Biology, Children s Hospital Research Foundation, Cincinnati, Ohio 45229 3039, USA
    J Neurosci 22:5188-97. 2002
    ....
  82. ncbi Identification and characterization of mouse Erbb2 gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 23:831-5. 2003
    The PPP1R1B-STARD3-TCAP-PNMT-MGC9753-ERBB2-MGC14832-GRB7 locus on human chromosome 17q12 is frequently amplified in human gastric and breast cancer...
  83. ncbi Transplanted hNT cells ("LBS neurons") in a rat model of huntington's disease: good survival, incomplete differentiation, and limited functional recovery
    Rosemary A Fricker-Gates
    School of Biosciences, Cardiff University, Cardiff, Wales, UK
    Cell Transplant 13:123-36. 2004
    ....
  84. ncbi Recent advances in cyclic-adenosine monophosphate/protein kinase A signaling in ethanol-induced synaptic and behavioral alterations
    L Judson Chandler
    Alcohol Research Center and Department of Physiology Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Alcohol Clin Exp Res 28:1129-36. 2004
    ..Morrisett; (4) and The cAMP/PKA signal transduction pathway modulates ethanol consumption and sedative effects of ethanol, by Gary S. Wand...
  85. pmc Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum
    Emmanuel Valjent
    Institut National de la Santé et de la Recherche Médicale and Université Pierre et Marie Curie U536, Signal Transduction and Plasticity in the Nervous System, Institut du Fer a Moulin, 17 Rue du Fer a Moulin, 75005 Paris, France
    Proc Natl Acad Sci U S A 102:491-6. 2005
    ....
  86. ncbi Adeno-associated virus-mediated gene transfer of human aromatic L-amino acid decarboxylase protects mixed striatal primary cultures from L-DOPA toxicity
    Mohammad M Doroudchi
    Avigen Inc, Alameda, California 94502, USA
    J Neurochem 93:634-40. 2005
    ..These results suggest a neuroprotective role for AADC gene transfer against L-DOPA toxicity...
  87. ncbi Effect of cocaine self-administration on striatal PKA-regulated signaling in male and female rats
    Wendy J Lynch
    Division of Molecular Psychiatry and Center for Genes and Behavior, Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, 34 Park Street, New Haven, CT 06508, USA
    Psychopharmacology (Berl) 191:263-71. 2007
    ..Chronic cocaine produces changes in the dopamine (DA)/D1/cAMP/protein kinase A (PKA)-regulated signaling pathway that may underlie the development of addiction...
  88. ncbi Dopamine modulation of prefrontal cortex interneurons occurs independently of DARPP-32
    Heather Trantham-Davidson
    Medical University of South Carolina, Department of Neuroscience, BSB 403, 173 Ashley Avenue, Charleston, SC 29425, USA
    Cereb Cortex 18:951-8. 2008
    ....
  89. ncbi Mechanism of over-activation in direct pathway mediated by dopamine D₁ receptor in rats with levodopa-induced dyskinesia
    Xue Bing Cao
    Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    Neurosci Bull 22:159-64. 2006
    ....
  90. pmc Induction of neostriatal neurogenesis slows disease progression in a transgenic murine model of Huntington disease
    Sung Rae Cho
    Department of Neurology, University of Rochester Medical Center, Rochester, New York, USA
    J Clin Invest 117:2889-902. 2007
    ..Thus, BDNF and Noggin induced striatal neuronal regeneration, delayed motor impairment, and extended survival in R6/2 mice, suggesting a new therapeutic strategy in Huntington disease...
  91. doi Preparation of a novel monoclonal antibody specific to DARPP-32
    Jianjun Yang
    Department of Digestive Surgery, Xijing Hospital of Digestive Diseases, Fourth Military Medical University of China, Xi an, Shaanxi Province, China
    Hybridoma (Larchmt) 29:351-4. 2010
    ..The results showed that DARPP-32 might play an important role in carcinogenesis and multidrug resistance of gastric cancer...
  92. doi Subdivisions of the turtle Pseudemys scripta subpallium based on the expression of regulatory genes and neuronal markers
    Nerea Moreno
    Department of Cell Biology, University Complutense of Madrid, Spain
    J Comp Neurol 518:4877-902. 2010
    ..On the basis of GABA, Pax6, Tbr1, tyrosine hydroxylase, Darpp32, and Nkx2...
  93. doi Profiles of DARPP-32 in the insular cortex with schizophrenia: a postmortem brain study
    Keisuke Nishiura
    Department of Neuropsychiatry, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima City, Fukushima 960 1295, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 35:1901-7. 2011
    ..05) in the schizophrenia group compared with the healthy control group. Our findings could partially explain the molecular basis of the pain threshold abnormalities found in patients with schizophrenia...
  94. doi Marked differences in neurochemistry and aggregates despite similar behavioural and neuropathological features of Huntington disease in the full-length BACHD and YAC128 mice
    Mahmoud A Pouladi
    Centre for Molecular Medicine and Therapeutics, University of British Columbia, and Child and Family Research Institute, Vancouver, BC, Canada
    Hum Mol Genet 21:2219-32. 2012
    ..Our findings highlight a similar profile of HD-like behavioural and neuropathological deficits and illuminate differences that inform the use of distinct endpoints in trials of therapeutic agents in the YAC128 and BACHD mice...
  95. pmc Genetic polymorphisms regulating dopamine signaling in the frontal cortex interact to affect target detection under high working memory load
    Christopher T Smith
    University of North Carolina, Chapel Hill
    J Cogn Neurosci 26:395-407. 2014
    ..Moreover, these data support an inverted-U model with intermediate levels of DA signaling optimizing performance on tasks requiring maintenance of mental representations in working memory. ..
  96. pmc Isoaspartate accumulation in mouse brain is associated with altered patterns of protein phosphorylation and acetylation, some of which are highly sex-dependent
    Zhenxia Qin
    Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 8:e80758. 2013
    ..We also uncovered unexpected differences in how male and female mice respond to isoAsp accumulation in the brain. ..
  97. pmc Feedback regulation mediated by Bcl-2 and DARPP-32 regulates inositol 1,4,5-trisphosphate receptor phosphorylation and promotes cell survival
    Ming Jin Chang
    Department of Medicine, Division of Hematology Oncology, Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH 44106
    Proc Natl Acad Sci U S A 111:1186-91. 2014
    ..This feedback mechanism appears to be exploited by high levels of Bcl-2 in chronic lymphocytic leukemia cells, repressing B-cell receptor-induced Ca(2+) elevation and apoptosis. ..
  98. doi Serotonin2C receptors modulate dopamine transmission in the nucleus accumbens independently of dopamine release: behavioral, neurochemical and molecular studies with cocaine
    Adeline Cathala
    Neurocentre Magendie, Physiopathology of Addiction Group, INSERM U862, France Université de Bordeaux, France
    Addict Biol 20:445-57. 2015
    ..In keeping with the tight relationship between locomotor activity and NAc DA function, this interaction could participate in the inhibitory control of cocaine-induced locomotor activity. ..
  99. doi Evaluation of NCS-1, DARPP-32, and neurotrophins in hippocampus and prefrontal cortex in rats submitted to sepsis
    Clarissa M Comim
    Postgraduate Program in Health Sciences, Laboratory of Experimental Neurosciences, Infectious Diseases Unit, University of South Santa Catarina, Palhoça, Santa Catarina, Brazil
    Synapse 68:474-9. 2014
    ....
  100. pmc Early white matter abnormalities, progressive brain pathology and motor deficits in a novel knock-in mouse model of Huntington's disease
    Jing Jin
    Division of Neurobiology, Department of Psychiatry and Behavioral Sciences
    Hum Mol Genet 24:2508-27. 2015
    ..reduction in striatal and cortical volume, accumulation of mutant huntingtin aggregation, decreased levels of DARPP32 and BDNF and altered striatal metabolites...
  101. pmc Involvement of the Striatal Medium Spiny Neurons of the Direct Pathway in the Motor Stimulant Effects of Phencyclidine
    Alessandra Bonito-Oliva
    Karolinska Institutet, Department of Neuroscience, Stockholm, Sweden Drs Bonito Olivia, Madjid, Ögren, and Fisone, and Ms DuPont
    Int J Neuropsychopharmacol . 2015
    ..We examined the effects of deletion of DARPP-32 in distinct populations of striatal MSNs, on the ability of PCP to induce motor activation and memory deficit...

Research Grants53

  1. GENETIC ABBERATIONS IN HPRT DEFICIENCY
    Theodore Friedmann; Fiscal Year: 2007
    ..We also plan to determine the biochemical and neurotransmitter effects of genetic correction of these functions by gene transfer techniques. ..
  2. Laurie J Ozelius; Fiscal Year: 2016
    ..Identification of a final common pathway in different forms of EOTD will aid in directing discovery of therapeutic targets for this currently incurable disorder. ..
  3. RAYMOND CHARLES KOEHLER; Fiscal Year: 2016
    ....
  4. Dopamine Signaling Mechanisms of Traumatic Brain Injury
    C Edward Dixon; Fiscal Year: 2013
    ..In survivors, TBI results in the persistent disturbance of cognitive functioning. This project seeks to examine key neurochemical mechanisms underlying cognitive deficits and to evaluate novel therapies to maximize recovery of function. ..
  5. Regulation of striatal cannabinoid CB1 receptors by DARPP32 and deltaFosB mediate
    Matthew F Lazenka; Fiscal Year: 2012
    ..The proposed studies will determine the effects of repeated cannabinoid administration on biochemical messengers that regulate activity in these brain regions. ..
  6. COCAINE AND BRAIN DEVELOPMENT
    Pradeep G Bhide; Fiscal Year: 2010
    ..of receptor mRNA, protein, binding sites, agonist- induced cyclic AMP synthesis, phosphorylation of CREB and DARPP 32. Specific Aim 2 will determine if the deficits in GABA neuron migration produced by the cocaine exposure can be ..
  7. The Role of Tissue Plasminogen Activator in a Mouse Spinal Cord Injury Model
    Noreen Bukhari; Fiscal Year: 2012
    ..We hypothesize that these events are dependent upon DARPP-32 expression. ..
  8. Structure-function of inositol trisphosphate receptor
    Ilya Bezprozvanny; Fiscal Year: 2009
    ..Dopamine-induced responses in striatal medium spiny neurons will be studied by Ca2+ imaging. Experiments with striatal neurons from DARPP-32 and D2 receptor knockout mice will be performed. ..
  9. RECEPTORS MEDIATING DRUG DEPENDENCE
    Susan R George; Fiscal Year: 2013
    ....
  10. WENDY JEAN LYNCH; Fiscal Year: 2016
    ..These studies will provide a much needed foundation for the development of hormonal, pharmacological, and/or molecular based therapeutics for cocaine abuse, especially in women. ..
  11. Specifying Human iPSC-derived Medium spiny Neurons for Cocaine Abuse Research
    Xin Ming Ma; Fiscal Year: 2012
    ..with striatal MSNs, while the iPSC-derived MSNs will be identified by immunostaining with antibodies specific DARPP32, GABA and dopamine receptors (D1R and D2R)...
  12. Molecular Maladaptations Following Developmental Loss of D1 Receptor Signaling
    Aliya L Frederick; Fiscal Year: 2012
    ..abstract_text> ..
  13. Role of DARPP-32: Individual Responsiveness to Nicotine
    Jun Zhu; Fiscal Year: 2010
    ....
  14. Paul Greengard; Fiscal Year: 2015
    ..Results from the three Projects will complement each other. In addition, there will be a significant level of collaboration between the three Projects, as well as close interaction of the three Projects with the Scientific Core. ..
  15. Huntington's Disease and Neurogenesis
    Lisa M Ellerby; Fiscal Year: 2012
    ..We are developing a potential therapy to protect neurons or replace them in Huntington's disease. ..
  16. REGION SPECIFIC PHOSPHOPROTEINS IN THE BASAL GANGLIA
    Paul Greengard; Fiscal Year: 2004
    ..Project (Scientific Core) will produce key materials and perform routine required for the other projects. ..
  17. Cell Type Specific Control of Neuronal Signaling
    MARTILIAS STEPHEN FARRELL; Fiscal Year: 2012
    ..The completion of this proposal will provide neuroscientists a powerful new tool to exclusively modulate GPCR signaling in specific neuronal populations. ..
  18. John F Neumaier; Fiscal Year: 2014
    ..We will examine the effects of 5-HT6 receptors on cilia and dendritic morphology, cyclic AMP production, DARPP32 hosphorylation, and gene expression using PCR arrays focusing on key pathways predicted to be sensitive to 5-HT6 ..
  19. Huntington's Disease and the Striatum
    Michelle E Ehrlich; Fiscal Year: 2010
    ..Knowledge of striatal-specific transcriptional regulation will also be highly relevant to other diseases of the basal ganglia in which transcriptional dysregulation plays a role. II. ..
  20. Induction of Striatal Regeneration in Huntington's Disease
    Steven Goldman; Fiscal Year: 2009
    ..The new striatal neurons project to the globus pallidus and adopt a DARPP32/GABAergic/calbindin+ phenotype, characteristic of medium spiny projection neurons...
  21. CHARACTERIZATION OF A NEURON-SPECIFIC PHOSPHOPROTEIN
    Samuel Gandy; Fiscal Year: 1990
    ....
  22. Role of Endocannabinoids in Levodopa-Induced Dyskinesias
    Andrea Giuffrida; Fiscal Year: 2012
    ..The study will identify new and more effective therapeutic strategies for the treatment of levodopa-associated motor complications. ..
  23. Wael El-Rifai; Fiscal Year: 2016
    ..Upon completion of our studies, the results will have a significant impact on understanding the biology of gastric cancer affecting our diagnostic, prognostic, and possibly clinical management of this disease. ..
  24. D2 TANTYCYTES IN THE REGULATION OF HPT AXIS
    RONALD LECHAN; Fiscal Year: 2001
    ....
  25. Translational Genetics and Dopamine Signaling in Sensitivity to Amphetamines
    CAMRON BRYANT; Fiscal Year: 2009
    ....
  26. MESOAMYGDALOID DOPAMINE NEURONS AND ANTIPSYCHOTIC DRUGS
    Clinton Kilts; Fiscal Year: 1993
    ..The effects of chronic antipsychotic drugs administration on the density and functional state of amygdaloid NT receptors will be determined...
  27. Intrabodies as novel neurological therapeutics
    Anne Messer; Fiscal Year: 2010
    ..These approaches should also be generally applicable for other neurodegenerative diseases that result from abnormal protein folding and accumulation, including Alzheimer's, Parkinson's, and prion diseases. ..
  28. Post-Synaptic Striatal TrkB: Role in the Response to Cocaine
    Michelle Ehrlich; Fiscal Year: 2009
    ..This application is focused on the delineation of the site of action of trkB, and what other molecules regulated by trkB may be implicated in the behavioral responses to cocaine. ..
  29. CHEMICAL NEUROANATOMY OF DOPAMINOCEPTIVE NEURONS
    Charles Ouimet; Fiscal Year: 1991
    ....
  30. INTRACELLULAR MOLECULES OF NICOTINE ADDICTION
    Noboru Hiroi; Fiscal Year: 2004
    ..If these molecules turn out to be important for vulnerability to nicotine addiction, this mouse study will provide a solid basis for genetic analysis of human addiction vulnerability. ..
  31. ONTOGENY OF NEUROADAPTIVE RESPONSES TO PSYCHOSTIMULANTS
    Michelle Ehrlich; Fiscal Year: 2002
    ..abstract_text> ..
  32. MECHANISMS OF DOPA-DYSKINESIAS IN PARKINSONIAN MODELS
    J Langston; Fiscal Year: 2004
    ..The results of this work will advance our understanding of the molecular mechanism responsible for the debilitating dyskinetic movements which occur as a consequence of long-term L-dopa treatment in Parkinson's disease. ..
  33. Basal Ganglia Expression of TorsinA in Transgenic Mice
    Michelle Ehrlich; Fiscal Year: 2005
    ..e. a dopamine agonist. ..
  34. DOPAMINE/GLUTAMATE AND HYPOXIC INJURY IN NEWBORN BRAIN
    David Wilson; Fiscal Year: 2009
    ..This understanding will be the basis for more effective treatment of patients who have been subjected to a period(s) of insufficient oxygen delivery to the brain. ..
  35. Signaling Mechanisms Underlying Neuroleptic Drug Actions
    Paul Greengard; Fiscal Year: 2009
    ..Thus, the proposed studies should provide a detailed knowledge on how neuroleptics affect protein phosphorylation pathways in defined neuronal circuitries. ..
  36. Huntington's Disease and the Striatum
    Diane Merry; Fiscal Year: 2006
    ..This will be accomplished by crossing of the already established D9/LacZ mouse with the R6/2 HD mouse model, in which endogenous DARPP-32 is down-regulated. ..
  37. Molecular Regulation of a Striatal DARPP-32 Phenotype
    Michelle Ehrlich; Fiscal Year: 2008
    ....
  38. PREFRONTAL CORTEX NEUROPHYSIOLOGY AFTER CHRONIC COCAINE
    Francis White; Fiscal Year: 2003
    ....
  39. Structural MR Analyses of Drug Exposed Brains
    Barry Kosofsky; Fiscal Year: 2008
    ..By developing and applying such tools we will not only address a clinically important problem, but we will develop methods that will be of general value to others pursuing pediatric neuroimaging studies. ..
  40. ZEISS LSM 510 NLO CONFOCAL/MULTIPHOTON SYSTEM WITH TI
    L Chandler; Fiscal Year: 2002
    ..A detailed organizational plan, substantial institutional support, and a long-term maintenance plan will ensure sustained viability and maximal use of the instrument. ..
  41. DOPAMINE AND RETINAL ADAPTATION
    Paul Witkovsky; Fiscal Year: 2001
    ....
  42. DOPAMINE 2002
    Kim Neve; Fiscal Year: 2002
    ..The banquet will feature informal talks by 2000 Nobel Prize Laureates, Arvid Carlsson and Paul Greengard, and the opening lecture will be given by Marc Caron, the organizer of Dopamine '94 in Quebec City. ..
  43. Neuropathology and Pathogenesis of Huntington's Disease
    Anton Reiner; Fiscal Year: 2008
    ..abstract_text> ..
  44. Characterization of Human Trace Amine Receptors
    Kim Neve; Fiscal Year: 2006
    ..TARs encoding full-length receptors are expressed on the cell surface, to identify agonists and antagonists for each TAR subtype, and to identify allelic variants that alter the function or ligand binding of a TAR subtype ..
  45. Cocaine-Induced Disturbances of Mouse Brain Development
    Barry Kosofsky; Fiscal Year: 2003
    ....
  46. Mouse Behavior Models of Cocaine Addiction
    Francis White; Fiscal Year: 2003
    ..The development of these models should allow phenotypic characterization of behaviors related to drug taking and drug seeking and provide novel tests for various transgenic mice. ..
  47. A PR-Induced Autocrine/Paracrine Pathway in Female Brain
    EDE APOSTOLAKIS; Fiscal Year: 2004
    ..This will furnish insight into the underlying cellular and molecular mechanisms that produce steroid receptor-dependent disease etiologies and should contribute to the development of new therapeutic strategies. ..
  48. Hormones Neuronal Phosphoproteins and Behavior
    SHAILAJA MANI; Fiscal Year: 2008
    ..These studies will provide information on the PKA/DARPP-32/PP-1 cascade regulation by progesterone and dopamine in mediating reproductive behavior. ..
  49. Sex, hormones and cocaine self-administration
    Wendy Lynch; Fiscal Year: 2006
    ..Thus, these studies may provide a basis for the development of novel treatment strategies for cocaine abuse/dependence, particularly in women. ..
  50. DOPAMINE MODULATION OF LIMBIC CORTICO ACCUMBENS SYSTEM
    Shao Pii Onn; Fiscal Year: 2004
    ..The proposed study is of particular interest with respect to the deficit syndrome in schizophrenia and possibly other mental disorders such as drug addiction associated with negative affect and depression. ..
  51. Steroid Hormones Regulatory Mechanisms and Behavior
    SHAILAJA MANI; Fiscal Year: 2006
    ..Identification of such cross-talk signaling mechanisms will contribute to our understanding of the environmental and internal determinants of hormone-brain-behavior mechanisms. ..