Genomes and Genes
Gene Symbol: PPP1R1B
Description: protein phosphatase 1 regulatory inhibitor subunit 1B
Alias: DARPP-32, DARPP32, protein phosphatase 1 regulatory subunit 1B, dopamine and cAMP-regulated neuronal phosphoprotein 32
Publications195 found, 100 shown here
- Identification of a dopamine- and 3'5'-cyclic adenosine monophosphate-regulated phosphoprotein of 32 kD (DARPP-32) in parathyroid hormone-producing cells of the human parathyroid glandB Meister
Department of Histology and Neurobiology, Karolinska Institute, Stockholm, Sweden
J Endocrinol Invest 14:655-61. 1991..The present results suggest that DARPP-32 may play a role in the cellular mechanisms leading to dopamine-induced PTH secretion...
- The significance of L-amino acid decarboxylase and DARPP-32 in the kidneyA Aperia
Department of Pediatrics, , Stockholm, Sweden
Am J Hypertens 3:11S-13S. 1990..The effect involves activation of cAMP protein kinase. It is likely that this effect is potentiated by DARPP-32...
- Gastric cancers overexpress DARPP-32 and a novel isoform, t-DARPPWa el El-Rifai
Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908 0708, USA
Cancer Res 62:4061-4. 2002..Our results reveal for the first time the presence of these signaling molecules in human cancer and suggest that they may be important for gastric tumorigenesis...
- Darpp-32: a novel antiapoptotic gene in upper gastrointestinal carcinomasAbbes Belkhiri
Digestive Health Center of Excellence and Department of Pathology, University of Virginia Health System, Charlottesville, Virginia 22908 0708, USA
Cancer Res 65:6583-92. 2005..The expression of Darpp-32 and t-Darpp is associated with a potent antiapoptotic advantage for cancer cells through a p53-independent mechanism that involves preservation of mitochondrial potential and increased Bcl2 levels...
- Dopamine D1 receptor-dependent modifications in the dopamine and cAMP-regulated phosphoprotein of Mr 32 kDa phosphorylation pattern in striatal areas of morphine-sensitized ratsS Scheggi
Department of Neuroscience, Pharmacology Unit, University of Siena, Italy
Neuroscience 163:627-39. 2009..Since DARPP-32 phosphorylated in Thr75 inhibits cAMP-dependent protein kinase (PKA) activity, the final result is a decrease in the dopamine D(1) receptor-dependent phosphorylation events...
- Characterization of the interaction between DARPP-32 and protein phosphatase 1 (PP-1): DARPP-32 peptides antagonize the interaction of PP-1 with binding proteinsY G Kwon
Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
Proc Natl Acad Sci U S A 94:3536-41. 1997....
- Functional dopamine-1 receptors and DARPP-32 are expressed in human ovary and granulosa luteal cells in vitroA Mayerhofer
Anatomisches Institut der Technischen Universität München, Germany
J Clin Endocrinol Metab 84:257-64. 1999..Taken together, the presence of DA and a functional DA receptor and DARPP-32 indicate that a novel, physiological regulatory pathway involving DA exists in the human ovary...
- D1-Receptor, DARPP-32, and PP-1 in the primate corpus luteum and luteinized granulosa cells: evidence for phosphorylation of DARPP-32 by dopamine and human chorionic gonadotropinA Mayerhofer
Anatomisches Institut, Universitat Munchen, D 80802 München, Germany
J Clin Endocrinol Metab 85:4750-7. 2000..The PP-1 inhibitor DARPP-32 may, thus, be a third messenger used by both DA and hCG/LH to exert common regulatory influences on the cells of the CL...
- Proteomic characterization of protein phosphatase 1 complexes in ischemia-reperfusion and ischemic toleranceCristina Cid
Department of Investigation, Hospital Ramon y Cajal, Madrid, Spain
Proteomics 7:3207-18. 2007..of heat shock cognate 71 kDa-protein, creatine kinase B, and dopamine- and cAMP-regulated phosphoprotein 32 kDa (DARPP32) with both PP1alpha and PP1gamma, and the interaction of phosphodiesterase-6B, transitional ER ATPase, lamin-A, ..
- Detailed structural characterization of unbound protein phosphatase 1 inhibitorsBarbara Dancheck
Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, Rhode Island 02912, USA
Biochemistry 47:12346-56. 2008..Together, these interactions enable potent and selective inhibition of PP1...
- DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1H C Hemmings
Nature 310:503-5. 1984..Thus, the basal ganglia of mammalian brain contain a region-specific neuronal phosphoprotein that is a protein phosphatase inhibitor...
- DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. I. Regional and cellular distribution in the rat brainS I Walaas
J Neurosci 4:84-98. 1984..W. Aswad, and P. Greengard (1984) J. Neurosci. 4: 99-110) and the immunocytochemical localization of this phosphoprotein (Ouimet, C.C., P. Miller, H.C. Hemmings, Jr., S.I. Walaas, and P. Greengard (1984) J. Neurosci. 4: 111-124)...
- Expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in human brain tissueS Brene
Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
J Neurosci 14:985-98. 1994....
- Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neuronsJ A Bibb
Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021, USA
Nature 402:669-71. 1999..Thus DARPP-32 is a bifunctional signal transduction molecule which, by distinct mechanisms, controls a serine/threonine kinase and a serine/threonine phosphatase...
- Overexpression of the 32-kilodalton dopamine and cyclic adenosine 3',5'-monophosphate-regulated phosphoprotein in common adenocarcinomasAndy Beckler
Department of Medicine, Division of Gastroenterology, University of Virginia Health System, Charlottesville, Virginia 22908 0708, USA
Cancer 98:1547-51. 2003..Recently, DARPP-32 and a truncated isoform, t-DARPP, have been cloned in gastric carcinoma. The extent of DARPP-32 and t-DARPP expression in human epithelial tissues and carcinomas remained unknown...
- Coamplified and overexpressed genes at ERBB2 locus in gastric cancerAsta Varis
Departments of Pathology and Medical Genetics, Haartman Institute, University of Helsinki and Helsinki University Central Hospital Laboratory Diagnostics, Helsinki, Finland
Int J Cancer 109:548-53. 2004..amplicon formation because this region harbors the ERBB2 oncogene and several other targets, such as TOP2A and DARPP32. In our study, we characterized the amplification (52 cases) and expression (29 cases) levels of ERBB2, TOP2A and ..
- DARPP-32 expression arises after a phase of dysplasia in oesophageal squamous cell carcinomaY Ebihara
Surgical Oncology, Cancer Medicine, Division of Cancer Medicine, Hokkaido University Graduate School of Medicine, N15W7 Kita ku, Sapporo, Hokkaido 060 8638, Japan
Br J Cancer 91:119-23. 2004..These observations suggest that DARPP-32 (rather than t-DARPP) expression arises after a phase of dysplasia in OSCC, and that tumours expressing DARPP-32 progress less rapidly than DARPP-32-negative tumours...
- Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognitionAndreas Meyer-Lindenberg
Unit for Systems Neuroscience in Psychiatry, Neuroimaging Core Facility, and Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute for Mental Health NIMH, NIH, Bethesda, MD 20892, USA
J Clin Invest 117:672-82. 2007Dopamine- and cAMP-regulated phosphoprotein of molecular weight 32 kDa (DARPP-32), encoded by PPP1R1B, is a pivotal integrator of information in dopaminoceptive neurons, regulating the response to neuroleptics, psychotomimetics, and ..
- Immunohistochemical and immunoblot analysis of Dopamine and cyclic AMP-regulated phosphoprotein, relative molecular mass 32,000 (DARPP-32) in the prefrontal cortex of subjects with schizophrenia and bipolar disorderMasanori Ishikawa
Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba City, Ibaraki 305 8575, Japan
Prog Neuropsychopharmacol Biol Psychiatry 31:1177-81. 2007....
- t-Darpp promotes cancer cell survival by up-regulation of Bcl2 through Akt-dependent mechanismAbbes Belkhiri
Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
Cancer Res 68:395-403. 2008..In conclusion, the t-Darpp/Akt axis underscores a novel oncogenic potential of t-Darpp in gastric carcinogenesis and resistance to drug-induced apoptosis...
- Expression of t-DARPP mediates trastuzumab resistance in breast cancer cellsAbbes Belkhiri
Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
Clin Cancer Res 14:4564-71. 2008..We have investigated the role of t-DARPP in trastuzumab resistance in ERBB2-amplified and overexpressed breast cancer cell lines...
- Anti-DARPP32 antibody-immunopositive inclusions in the brain of patients with multiple system atrophyY Honjo
Department of Neurology, Faculty of Medicine, Kyoto University, Kyoto, Japan
Clin Neuropathol 27:309-16. 2008..Among these substrates, tau and MAP 1B are immunopositive in GCIs. DARPP32 has been identified as a target for dopamine and PKA in the striatum...
- Replication study of candidate genes for cognitive abilities: the Lothian Birth Cohort 1936L M Houlihan
Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK
Genes Brain Behav 8:238-47. 2009..The genes include BDNF, COMT, DISC1, KL, NCSTN, PPP1R1B, PRNP, SHANK3, SORL1 and WRN...
- Both t-Darpp and DARPP-32 can cause resistance to trastuzumab in breast cancer cells and are frequently expressed in primary breast cancersSophie Hamel
Department of Oncology and Surgery, Segal Cancer Center, Sir Mortimer B Davis Jewish General Hospital, 3755 Cote Ste Catherine, Montreal, QC, H3T 1E2, Canada
Breast Cancer Res Treat 120:47-57. 2010..The most overexpressed gene in these subclones was PPP1R1B, encoding the DARPP-32 phosphatase inhibitor...
- Wnt-5a-induced phosphorylation of DARPP-32 inhibits breast cancer cell migration in a CREB-dependent mannerChristian Hansen
Experimental Pathology, Department of Laboratory Medicine, Lund University, CRC, 205 02 Malmo, Sweden
J Biol Chem 284:27533-43. 2009....
- t-DARPP regulates phosphatidylinositol-3-kinase-dependent cell growth in breast cancerBhavatarini Vangamudi
Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Mol Cancer 9:240. 2010..In this study, we evaluated expression of t-DARPP in human primary breast tumors, and investigated the role of t-DARPP in regulating growth and proliferation in breast cancer cells...
- Infusions of anti-sense oligonucleotides for DARPP-32 to the ventral tegmental area reduce effects of progesterone- and a dopamine type 1-like receptor agonist to facilitate lordosisCheryl A Frye
Department of Psychology, The University at Albany State University of New York, Albany, NY 12222, United States
Behav Brain Res 206:286-92. 2010..Together, these findings suggest that, in the midbrain VTA, P4's actions to facilitate sexual behavior of female rodents, involving D1 receptors, may require DARPP-32...
- Histone H3 phosphorylation is under the opposite tonic control of dopamine D2 and adenosine A2A receptors in striatopallidal neuronsJesus Bertran-Gonzalez
INSERM, UMR S 839, Paris, France
Neuropsychopharmacology 34:1710-20. 2009..Thus, blockade of D2Rs promotes histone H3 phosphorylation through the A2AR-mediated activation of Galpha(olf) and inhibition of protein phosphatase-1 (PP-1) through the PKA-dependent phosphorylation of DARPP-32...
- Expression of D1 but not D2 dopamine receptors in striatal neurons producing neurokinin B in ratsTakahiro Sonomura
Department of Anatomy for Oral Sciences, Graduate School of Medical and Dental Sciences, Advanced Therapeutic Course, Field of Neurology, Kagoshima University, Kagoshima 890 8544, Japan
Eur J Neurosci 26:3093-103. 2007....
- Evaluation of neuronal phosphoproteins as effectors of caffeine and mediators of striatal adenosine A2A receptor signalingBogachan Sahin
Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Brain Res 1129:1-14. 2007..Finally, the phosphorylation state of these proteins was further assessed in vivo by systemic administration of caffeine...
- Nerve agent exposure elicits site-specific changes in protein phosphorylation in mouse brainHongwen Zhu
Department of Molecular Neuropharmacology, Intra Cellular Therapies, Inc ITI, Audubon Business and Technology Center, 3960 Broadway, New York, NY 10032, USA
Brain Res 1342:11-23. 2010..This approach identifies specific targets for nerve agents, including substrates for Cdk5 kinase, which may be the basis for new anti-convulsant therapies...
- Dopamine receptor modulation of hypoxic-ischemic neuronal injury in striatum of newborn pigletsZeng Jin Yang
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Cereb Blood Flow Metab 27:1339-51. 2007..Furthermore, mechanisms of D1 receptor toxicity may involve DARPP-32-dependent phosphorylation of NMDA receptor NR1 and Na(+),K(+)-ATPase...
- Synergistic interactions of dopamine D1 and glutamate NMDA receptors in rat hippocampus and prefrontal cortex: involvement of ERK1/2 signalingK Sarantis
Physiology Department, Medical School, University of Patras, Rio, Patras, Greece
Neuroscience 163:1135-45. 2009....
- Organization of the avian basal forebrain: chemical anatomy in the parrot (Melopsittacus undulatus)Todd Freeman Roberts
Department of Psychology, University of Maryland, College Park, Maryland 20742, USA
J Comp Neurol 454:383-408. 2002..The budgerigar septal region is theorized to be homologous as a field to the mammalian septum. Our results are discussed with regard to both the evolution of the basal forebrain and its role in vocal learning processes...
- Anatomical markers for the subdivisions of the barn owl's inferior-collicular complex and adjacent peri- and subventricular structuresHermann Wagner
Institut fur Biologie II, Rheinisch Westfaelishe Technische Hochschule Aachen, D 52074 Aachen, Germany
J Comp Neurol 465:145-59. 2003..None of the markers delineated the border between the medial and lateral shell of ICC...
- A role for casein kinase 1 epsilon in the locomotor stimulant response to methamphetamineCamron D Bryant
Department of Human Genetics, University of Chicago, 920 E 58th St CLSC 507D, Chicago, IL 60637, USA
Psychopharmacology (Berl) 203:703-11. 2009..Based on these results, we hypothesized that differential expression of Csnk1-epsilon causes differential sensitivity to MA-induced locomotor activity in mice...
- Neuropathological and behavioral changes induced by various treatment paradigms with MPTP and 3-nitropropionic acid in mice: towards a model of striatonigral degeneration (multiple system atrophy)Nadia Stefanova
Department of Neurology, University Hospital of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
Acta Neuropathol 106:157-66. 2003..This suggests that complex integrative mechanisms are likely to regulate the vulnerability of the striatum and SNc to cell death in SND/MSA-P...
- Cooperation between D1- and D2-dopamine receptors in the nucleus accumbensA Szmigielski
Department of Pharmacodynamics, Medical Academy, Lodz, Poland
Neuropharmacology 30:259-66. 1991..The results suggest that D1 and D2 receptors in the nucleus accumbens could cooperate with the same adenylate cyclase and could be located on the same neurones...
- A Theileria parva type 1 protein phosphatase activityX Cayla
Laboratoire de Physiologie de la Reproduction, INRA CNRS ESA 7080, 9 quai Saint Bernard, 75005, Paris, France
Mol Biochem Parasitol 110:161-6. 2000..Intriguingly, since type 1 OA-sensitive phosphatase activity has been recently described in Plasmodium falciparum, we can conclude that these medically important parasites produce their one PP1...
- General anesthetics selectively modulate glutamatergic and dopaminergic signaling via site-specific phosphorylation in vivoGretchen L Snyder
Department of Neuropharmacology, Intra Cellular Therapies, Inc ITI, Audubon Business and Technology Center, 3960 Broadway, New York, NY 10032, USA
Neuropharmacology 53:619-30. 2007..This novel approach indicates a role for phosphorylation-mediated down-regulation of glutamatergic synaptic transmission by general anesthetics and identifies specific in vivo targets for focused evaluation of anesthetic mechanisms...
- RARbeta isoform-specific regulation of DARPP-32 gene expression: an ectopic expression study in the developing rat telencephalonWen Lin Liao
Institute of Neuroscience, National Yang Ming University, 155 Li Rum Street, Taipei 11211, Taiwan
Eur J Neurosci 21:3262-8. 2005..The molecular diversity of RARbeta isoforms may underlie parts of the complex gene regulation by retinoids during neural development...
- Regulation of cyclin-dependent kinase 5 and casein kinase 1 by metabotropic glutamate receptorsF Liu
Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
Proc Natl Acad Sci U S A 98:11062-8. 2001..Together these results indicate that a CK1-Cdk5-DARPP-32 cascade may be involved in the regulation by mGluR agonists of Ca(2+) channels...
- Caffeine and a selective adenosine A2A receptor antagonist induce reward and sensitization behavior associated with increased phospho-Thr75-DARPP-32 in miceChih W Hsu
Department of Emergency Medicine, Tzu Chi General Hospital, Hualien 970, Taiwan
Psychopharmacology (Berl) 204:313-25. 2009....
- Immunohistochemical localization of DARPP-32 in the brain of the lizard, Gekko gecko: co-occurrence with tyrosine hydroxylaseW J Smeets
The Graduate School of Neurosciences Amsterdam, Research Institute of Neurosciences and Department of Anatomy, Vrije Universiteit, Amsterdam, The Netherlands
J Comp Neurol 435:194-210. 2001....
- Immunohistochemical localization of DARPP-32 in the brain of the turtle, Pseudemys scripta elegans: further assessment of its relationship with dopaminergic systems in reptilesWilhelmus J A J Smeets
Department of Anatomy, The Graduate School of Neurosciences Amsterdam, Research Institute of Neurosciences, Vrije Universiteit Medisch Centrum, Van der Boechorststraat 7, BT 1081 Amsterdam, The Netherlands
J Chem Neuroanat 25:83-95. 2003..At the same time, however, it demonstrates that substantial species differences exist, some of which may be related to differences previously observed in the dopaminergic systems...
- The homeobox gene Gsh2 is required for retinoid production in the embryonic mouse telencephalonRonald R Waclaw
Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Development 131:4013-20. 2004..Thus, in addition to the previously described role for Gsh2 to maintain correct molecular identity in the LGE, our results demonstrate a novel requirement of this gene for retinoid production within the ventral telencephalon...
- The B''/PR72 subunit mediates Ca2+-dependent dephosphorylation of DARPP-32 by protein phosphatase 2AJung Hyuck Ahn
Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
Proc Natl Acad Sci U S A 104:9876-81. 2007..In addition, our studies reveal an alternative intracellular mechanism whereby Ca(2+) can activate serine/threonine phosphatase activity...
- Blockade of adenosine A2A receptors downregulates DARPP-32 but increases ERK1/2 activity in striatum of dopamine deficient "weaver" mouseKonstantinos Botsakis
Laboratory of Human and Animal Physiology, Department of Biology, University of Patras, Patras, Greece
Neurochem Int 56:245-9. 2010..e. in "weaver" animals A(2A) receptor blockade increases the activity of ERK1/2 cascade. This could be of clinical relevance since A(2A) antagonists are already used in clinical trials for ameliorating Parkinson's disease (PD) symptoms...
- Differential fate and functional outcome of lithium chloride primed adult neural progenitor cell transplants in a rat model of Huntington diseaseElena M Vazey
Department of Pharmacology and Clinical Pharmacology, Centre for Brain Research, Faculty of Medical Health Sciences, The University of Auckland, Private Bag 92019, Auckland Mail Centre, Auckland 1142, New Zealand
Stem Cell Res Ther 1:41. 2010....
- Glutamate regulation of DARPP-32 phosphorylation in neostriatal neurons involves activation of multiple signaling cascadesAkinori Nishi
Department of Pharmacology, Kurume University School of Medicine, Kurume, Fukuoka 830 0011, Japan
Proc Natl Acad Sci U S A 102:1199-204. 2005....
- Nucleus accumbens subregions: hodological and immunohistochemical study in the domestic chick (Gallus domesticus)Eszter Bálint
Department of Anatomy, Semmelweis University, 58 Tuzolto utca, H 1450, Budapest, Hungary
Cell Tissue Res 327:221-30. 2007..6 into a putative shell and core by the methods employed in the present study. This region probably corresponds to the rostral pole of the nucleus accumbens...
- The importance of A9 dopaminergic neurons in mediating the functional benefits of fetal ventral mesencephalon transplants and levodopa-induced dyskinesiasWei Li Kuan
Cambridge Centre for Brain Repair, Forvie Site, Robinson Way, Cambridge CB2 2PY, UK
Neurobiol Dis 25:594-608. 2007..These results suggest that an A9 dopaminergic neuron-enriched transplant may be the key to an effective PD cell replacement therapy through normalisation of the altered striatal expression of Cdk5/DARPP-32...
- The internal state of medium spiny neurons varies in response to different input signalsZhen Qi
Department of Biomedical Engineering, Georgia Institute of Technology and Emory University Medical School, Atlanta, GA 30332, USA
BMC Syst Biol 4:26. 2010..DARPP-32's unique capacity of faithfully converting distinct neurotransmitter signals into appropriate responses is achieved through a complex phosphorylation-dephosphorylation system that evades intuition and predictability...
- Distinct changes in cAMP and extracellular signal-regulated protein kinase signalling in L-DOPA-induced dyskinesiaEmanuela Santini
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
PLoS ONE 5:e12322. 2010..However, very little is known, in non-human primates, about the regulation of these signalling cascades and their association with the induction, manifestation and/or maintenance of dyskinesia...
- DARPP-32 knockout mice exhibit impaired reversal learning in a discriminated operant taskC J Heyser
Department of Psychology, Franklin and Marshall College, P O Box 3003, Lancaster, PA 17604, USA
Brain Res 867:122-30. 2000..These results provide evidence for a functional role of DARPP-32 in the mediation of processes underlying learning and memory...
- In vivo magnetic resonance imaging of embryonic neural grafts in a rat model of striatonigral degeneration (multiple system atrophy)M F Schocke
Department of Magnetic Resonance Imaging and Spectroscopy, Department of Neurology, Department of Anaesthesia, The Leopold Franzens University of Innsbruck, Anichstrasse 35, Innsbruck, 6020, Austria
Neuroimage 12:209-18. 2000..5 Tesla MRI scanner. Additionally, we obtained an excellent correlation between MRI and histological measurements...
- Phenotypic studies on dopamine receptor subtype and associated signal transduction mutants: insights and challenges from 10 years at the psychopharmacology-molecular biology interfaceJohn L Waddington
Institute of Biopharmaceutical Sciences, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
Psychopharmacology (Berl) 181:611-38. 2005..Furthermore, there are poorly understood methodological factors that contribute to inconsistent phenotypic findings between laboratories...
- Gene expression differences in mice divergently selected for methamphetamine sensitivityAbraham A Palmer
Columbia Genome Center, Columbia University, 1150 St Nicholas Ave, New York, New York 10032, USA
Mamm Genome 16:291-305. 2005..The identified genes provide excellent candidates for future hypothesis-driven studies, translational genetic studies, and pharmacological interventions...
- Association between the casein kinase 1 epsilon gene region and subjective response to D-amphetamineJeremy Veenstra-Vanderweele
Institute of Juvenile Research, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60637, USA
Neuropsychopharmacology 31:1056-63. 2006..001), which corresponded to a leftward shift in the dose-response curve. These findings demonstrate the successful translation of pharmacogenetic results from mice to humans...
- Protein components of the blood-brain barrier (BBB) in the brainstem area postrema-nucleus tractus solitarius regionNasren Maolood
Department of Neuroscience, The Retzius Laboratory, Retzius vag 8, Karolinska Institutet, SE 171 77 Stockholm, Sweden
J Chem Neuroanat 37:182-95. 2009..Such vessels may represent a route of entry for circulating substances to neurons in the NTS that inter alia regulate energy balance...
- D(2) dopamine receptors induce mitogen-activated protein kinase and cAMP response element-binding protein phosphorylation in neuronsZ Yan
Laboratory of Molecular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Proc Natl Acad Sci U S A 96:11607-12. 1999..Our results suggest that MAPK and CREB signaling cascades are involved in the regulation of gene expression and other long-term effects of D(2) receptor activation...
- Genetic conservation of the immunophilin-binding domains of human calcineurin A1 and A2I J Brogan
Immunology Research Group, School of Biological Sciences, University of Manchester, UK
Transpl Immunol 8:139-41. 2000..These results suggest that this region is highly conserved and cannot account for individual variation in response of patients to FK506 and CsA treatment...
- Chronic systemic complex I inhibition induces a hypokinetic multisystem degeneration in ratsGünter U Höglinger
INSERM U 289, Experimental Neurology and Therapeutics, Hopital de la Salpetriere, Paris, France
J Neurochem 84:491-502. 2003....
- Immunohistochemical localization of DARPP32 in striatal projection neurons and striatal interneurons in pigeonsA Reiner
Department of Anatomy and Neurobiology, The University of Tennessee Memphis, The Health Science Center, 38163, USA
J Chem Neuroanat 16:17-33. 1998b>DARPP32 is a D1-receptor associated signaling protein found in striatal projection neurons in mammals, including both substance P-containing (SP+) neurons and enkephalinergic (ENK+) projection neurons...
- The role of the cannabinoid type 1 receptor and down-stream cAMP/DARPP-32 signal in the nucleus accumbens of methamphetamine-sensitized ratsYao Chang Chiang
Laboratory of Neuropharmacology, Department of Physiology and Pharmacology, Chang Gung University and Molecular Imaging Center, Chang Gung Hospital, Kwei Shan, Tao Yuan, Taiwan, Republic of China
J Neurochem 103:2505-17. 2007..Overall, we demonstrated that brain CB(1) receptor and its down-stream cAMP/DARPP-32/T34/PP-2B signaling are profoundly altered in methamphetamine-sensitized animals...
- PKA-mediated responses in females' estrous cycle affect cocaine-induced responses in dopamine-mediated intracellular cascadesJ Weiner
Doctoral Subprogram in Biopsychology and Behavioral Neuroscience, City University of New York, New York, NY 10065, USA
Neuroscience 161:865-76. 2009..Taken together, these novel findings suggest that hormonal fluctuations during the estrous cycle may contribute to the previously reported sex differences in the PKA pathway and in behavioral responses to cocaine...
- Localization of dopamine D1 receptors and dopaminoceptive neurons in the chick forebrainR Schnabel
Federal Institute for Neurobiology, Magdeburg, Germany
J Comp Neurol 388:146-68. 1997..These results indicate that DARPP-32 as well as D1 receptors in the avian forebrain reveal a distribution that is substantially similar to that of mammals...
- Ethologically based resolution of D2-like dopamine receptor agonist-versus antagonist-induced behavioral topography in dopamine- and adenosine 3',5'-monophosphate-regulated phosphoprotein of 32 kDa "knockout" mutants congenic on the C57BL/6 geneRachel E Nally
Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
J Pharmacol Exp Ther 310:1281-7. 2004..Critically, the present data indicate that phenotypic effects of a given gene deletion using an agonist acting on the system disrupted cannot be generalized to a corresponding antagonist, and vice versa...
- Paradoxical striatal cellular signaling responses to psychostimulants in hyperactive miceJean Martin Beaulieu
Department of Cell Biology, Duke University Medical Center, Research Drive, Durham, NC 27710, USA
J Biol Chem 281:32072-80. 2006....
- Cell type-specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugsHelen S Bateup
Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Ave, New York, New York 10065, USA
Nat Neurosci 11:932-9. 2008..Furthermore, we found that a variety of drugs that target the striatum have cell type-specific effects that previous methods were not able to discern...
- The proline-rich N-terminal sequence of calcineurin Abeta determines substrate bindingSusann Kilka
Max Planck Research Unit for Enzymology of Protein Folding, Weinbergweg 22, D 06120 Halle Saale, Germany
Biochemistry 48:1900-10. 2009....
- Abnormal social behavior, hyperactivity, impaired remote spatial memory, and increased D1-mediated dopaminergic signaling in neuronal nitric oxide synthase knockout miceKoichi Tanda
Genetic Engineering and Functional Genomics Group, Horizontal Medical Research Organization, Kyoto University Graduate School of Medicine, Kyoto, Japan
Mol Brain 2:19. 2009..We also examined the role of nNOS in dopamine/DARPP-32 signaling in striatal slices from nNOS KO mice and the effects of the administration of a dopamine D1 receptor agonist on behavior in nNOS KO mice...
- Developmental exposure to manganese increases adult susceptibility to inflammatory activation of glia and neuronal protein nitrationJulie A Moreno
Center for Environmental Medicine, Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
Toxicol Sci 112:405-15. 2009..These data indicate that subchronic exposure to Mn during development leads to temporally distinct patterns of glial activation that result in elevated nitrosative stress in distinct populations of basal ganglia neurons...
- Incubation of nicotine seeking is associated with enhanced protein kinase A-regulated signaling of dopamine- and cAMP-regulated phosphoprotein of 32 kDa in the insular cortexAmir Abdolahi
Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, 1670 Discovery Drive, Charlottesville, VA 22911, USA
Eur J Neurosci 31:733-41. 2010....
- GABAergic neurons from mouse embryonic stem cells possess functional properties of striatal neurons in vitro, and develop into striatal neurons in vivo in a mouse model of Huntington's diseaseEunju Shin
Institute for Science and Technology in Medicine, Keele University, Keele ST5 5BG, UK
Stem Cell Rev 8:513-31. 2012..method-derived GABAergic neurons expressed the MSN marker dopamine- and cyclic AMP-regulated phosphoprotein (DARPP32)...
- Relation of addiction genes to hypothalamic gene changes subserving genesis and gratification of a classic instinct, sodium appetiteWOLFGANG B LIEDTKE
Department of Medicine, Duke University, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 108:12509-14. 2011..Our findings outline a molecular logic for instinctive behavior encoded by the brain with possible important translational-medical implications...
- Candidate gene-based association study of antipsychotic-induced movement disorders in long-stay psychiatric patients: a prospective studyP Roberto Bakker
Psychiatric Centre GGZ Centraal, Amersfoort, The Netherlands
PLoS ONE 7:e36561. 2012..and bradykinesia), as well as a principal-factor of the movement disorders and their subtypes, were examined for association with variation in 10 candidate genes (PPP1R1B, BDNF, DRD3, DRD2, HTR2A, HTR2C, COMT, MnSOD, CYP1A2, and RGS2).
- Proteomic analysis of alterations induced by perinatal hypoxic-ischemic brain injuryKatja Rosenkranz
Department of Functional Proteomics, Ruhr University Bochum, Germany
J Proteome Res 11:5794-803. 2012..Active forms of Calcineurin are associated with the dephosphorylation of Darpp-32, an effect that was also demonstrated in lesioned hemispheres after perinatal brain injury...
- ERK regulation of phosphodiesterase 4 enhances dopamine-stimulated AMPA receptor membrane insertionRoy S Song
Departments of Pharmacology and Systems Therapeutics, Friedman Brain Institute, and System Biology Center NY, Icahn School of Medicine at Mount Sinai, New York, NY 10029
Proc Natl Acad Sci U S A 110:15437-42. 2013..The combination of dynamical models and experiments has helped us unravel the complex interactions between two protein kinase pathways in regulating a fundamental molecular process underlying synaptic plasticity. ..
- Rat DARPP-32: cloning, sequencing, and characterization of the cDNAM E Ehrlich
Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, New York 10021
J Mol Neurosci 2:1-10. 1990..Unilateral destruction of the nigrostriatal dopaminergic pathway by injection of 6-hydroxydopamine (6-OHDA) into the substantia nigra did not alter the striatal steady state levels of DARPP-32 mRNA...
- Phosphodiesterase 1B knock-out mice exhibit exaggerated locomotor hyperactivity and DARPP-32 phosphorylation in response to dopamine agonists and display impaired spatial learningTracy M Reed
Division of Developmental Biology, Children s Hospital Research Foundation, Cincinnati, Ohio 45229 3039, USA
J Neurosci 22:5188-97. 2002....
- Identification and characterization of mouse Erbb2 gene in silicoMasuko Katoh
M and M Medical BioInformatics, Narashino 275 0022, Japan
Int J Oncol 23:831-5. 2003The PPP1R1B-STARD3-TCAP-PNMT-MGC9753-ERBB2-MGC14832-GRB7 locus on human chromosome 17q12 is frequently amplified in human gastric and breast cancer...
- Transplanted hNT cells ("LBS neurons") in a rat model of huntington's disease: good survival, incomplete differentiation, and limited functional recoveryRosemary A Fricker-Gates
School of Biosciences, Cardiff University, Cardiff, Wales, UK
Cell Transplant 13:123-36. 2004....
- Recent advances in cyclic-adenosine monophosphate/protein kinase A signaling in ethanol-induced synaptic and behavioral alterationsL Judson Chandler
Alcohol Research Center and Department of Physiology Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Alcohol Clin Exp Res 28:1129-36. 2004..Morrisett; (4) and The cAMP/PKA signal transduction pathway modulates ethanol consumption and sedative effects of ethanol, by Gary S. Wand...
- Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatumEmmanuel Valjent
Institut National de la Santé et de la Recherche Médicale and Université Pierre et Marie Curie U536, Signal Transduction and Plasticity in the Nervous System, Institut du Fer a Moulin, 17 Rue du Fer a Moulin, 75005 Paris, France
Proc Natl Acad Sci U S A 102:491-6. 2005....
- Adeno-associated virus-mediated gene transfer of human aromatic L-amino acid decarboxylase protects mixed striatal primary cultures from L-DOPA toxicityMohammad M Doroudchi
Avigen Inc, Alameda, California 94502, USA
J Neurochem 93:634-40. 2005..These results suggest a neuroprotective role for AADC gene transfer against L-DOPA toxicity...
- Effect of cocaine self-administration on striatal PKA-regulated signaling in male and female ratsWendy J Lynch
Division of Molecular Psychiatry and Center for Genes and Behavior, Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, 34 Park Street, New Haven, CT 06508, USA
Psychopharmacology (Berl) 191:263-71. 2007..Chronic cocaine produces changes in the dopamine (DA)/D1/cAMP/protein kinase A (PKA)-regulated signaling pathway that may underlie the development of addiction...
- Dopamine modulation of prefrontal cortex interneurons occurs independently of DARPP-32Heather Trantham-Davidson
Medical University of South Carolina, Department of Neuroscience, BSB 403, 173 Ashley Avenue, Charleston, SC 29425, USA
Cereb Cortex 18:951-8. 2008....
- Mechanism of over-activation in direct pathway mediated by dopamine D₁ receptor in rats with levodopa-induced dyskinesiaXue Bing Cao
Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
Neurosci Bull 22:159-64. 2006....
- Induction of neostriatal neurogenesis slows disease progression in a transgenic murine model of Huntington diseaseSung Rae Cho
Department of Neurology, University of Rochester Medical Center, Rochester, New York, USA
J Clin Invest 117:2889-902. 2007..Thus, BDNF and Noggin induced striatal neuronal regeneration, delayed motor impairment, and extended survival in R6/2 mice, suggesting a new therapeutic strategy in Huntington disease...
- Preparation of a novel monoclonal antibody specific to DARPP-32Jianjun Yang
Department of Digestive Surgery, Xijing Hospital of Digestive Diseases, Fourth Military Medical University of China, Xi an, Shaanxi Province, China
Hybridoma (Larchmt) 29:351-4. 2010..The results showed that DARPP-32 might play an important role in carcinogenesis and multidrug resistance of gastric cancer...
- Subdivisions of the turtle Pseudemys scripta subpallium based on the expression of regulatory genes and neuronal markersNerea Moreno
Department of Cell Biology, University Complutense of Madrid, Spain
J Comp Neurol 518:4877-902. 2010..On the basis of GABA, Pax6, Tbr1, tyrosine hydroxylase, Darpp32, and Nkx2...
- Profiles of DARPP-32 in the insular cortex with schizophrenia: a postmortem brain studyKeisuke Nishiura
Department of Neuropsychiatry, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima City, Fukushima 960 1295, Japan
Prog Neuropsychopharmacol Biol Psychiatry 35:1901-7. 2011..05) in the schizophrenia group compared with the healthy control group. Our findings could partially explain the molecular basis of the pain threshold abnormalities found in patients with schizophrenia...
- Marked differences in neurochemistry and aggregates despite similar behavioural and neuropathological features of Huntington disease in the full-length BACHD and YAC128 miceMahmoud A Pouladi
Centre for Molecular Medicine and Therapeutics, University of British Columbia, and Child and Family Research Institute, Vancouver, BC, Canada
Hum Mol Genet 21:2219-32. 2012..Our findings highlight a similar profile of HD-like behavioural and neuropathological deficits and illuminate differences that inform the use of distinct endpoints in trials of therapeutic agents in the YAC128 and BACHD mice...
- Genetic polymorphisms regulating dopamine signaling in the frontal cortex interact to affect target detection under high working memory loadChristopher T Smith
University of North Carolina, Chapel Hill
J Cogn Neurosci 26:395-407. 2014..Moreover, these data support an inverted-U model with intermediate levels of DA signaling optimizing performance on tasks requiring maintenance of mental representations in working memory. ..
- Isoaspartate accumulation in mouse brain is associated with altered patterns of protein phosphorylation and acetylation, some of which are highly sex-dependentZhenxia Qin
Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, California, United States of America
PLoS ONE 8:e80758. 2013..We also uncovered unexpected differences in how male and female mice respond to isoAsp accumulation in the brain. ..
- Feedback regulation mediated by Bcl-2 and DARPP-32 regulates inositol 1,4,5-trisphosphate receptor phosphorylation and promotes cell survivalMing Jin Chang
Department of Medicine, Division of Hematology Oncology, Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH 44106
Proc Natl Acad Sci U S A 111:1186-91. 2014..This feedback mechanism appears to be exploited by high levels of Bcl-2 in chronic lymphocytic leukemia cells, repressing B-cell receptor-induced Ca(2+) elevation and apoptosis. ..
- Serotonin2C receptors modulate dopamine transmission in the nucleus accumbens independently of dopamine release: behavioral, neurochemical and molecular studies with cocaineAdeline Cathala
Neurocentre Magendie, Physiopathology of Addiction Group, INSERM U862, France Université de Bordeaux, France
Addict Biol 20:445-57. 2015..In keeping with the tight relationship between locomotor activity and NAc DA function, this interaction could participate in the inhibitory control of cocaine-induced locomotor activity. ..
- Evaluation of NCS-1, DARPP-32, and neurotrophins in hippocampus and prefrontal cortex in rats submitted to sepsisClarissa M Comim
Postgraduate Program in Health Sciences, Laboratory of Experimental Neurosciences, Infectious Diseases Unit, University of South Santa Catarina, Palhoça, Santa Catarina, Brazil
Synapse 68:474-9. 2014....
- Early white matter abnormalities, progressive brain pathology and motor deficits in a novel knock-in mouse model of Huntington's diseaseJing Jin
Division of Neurobiology, Department of Psychiatry and Behavioral Sciences
Hum Mol Genet 24:2508-27. 2015..reduction in striatal and cortical volume, accumulation of mutant huntingtin aggregation, decreased levels of DARPP32 and BDNF and altered striatal metabolites...
- Involvement of the Striatal Medium Spiny Neurons of the Direct Pathway in the Motor Stimulant Effects of PhencyclidineAlessandra Bonito-Oliva
Karolinska Institutet, Department of Neuroscience, Stockholm, Sweden Drs Bonito Olivia, Madjid, Ögren, and Fisone, and Ms DuPont
Int J Neuropsychopharmacol . 2015..We examined the effects of deletion of DARPP-32 in distinct populations of striatal MSNs, on the ability of PCP to induce motor activation and memory deficit...
- GENETIC ABBERATIONS IN HPRT DEFICIENCYTheodore Friedmann; Fiscal Year: 2007..We also plan to determine the biochemical and neurotransmitter effects of genetic correction of these functions by gene transfer techniques. ..
- Laurie J Ozelius; Fiscal Year: 2016..Identification of a final common pathway in different forms of EOTD will aid in directing discovery of therapeutic targets for this currently incurable disorder. ..
- RAYMOND CHARLES KOEHLER; Fiscal Year: 2016....
- Dopamine Signaling Mechanisms of Traumatic Brain InjuryC Edward Dixon; Fiscal Year: 2013..In survivors, TBI results in the persistent disturbance of cognitive functioning. This project seeks to examine key neurochemical mechanisms underlying cognitive deficits and to evaluate novel therapies to maximize recovery of function. ..
- Regulation of striatal cannabinoid CB1 receptors by DARPP32 and deltaFosB mediateMatthew F Lazenka; Fiscal Year: 2012..The proposed studies will determine the effects of repeated cannabinoid administration on biochemical messengers that regulate activity in these brain regions. ..
- COCAINE AND BRAIN DEVELOPMENTPradeep G Bhide; Fiscal Year: 2010..of receptor mRNA, protein, binding sites, agonist- induced cyclic AMP synthesis, phosphorylation of CREB and DARPP 32. Specific Aim 2 will determine if the deficits in GABA neuron migration produced by the cocaine exposure can be ..
- The Role of Tissue Plasminogen Activator in a Mouse Spinal Cord Injury ModelNoreen Bukhari; Fiscal Year: 2012..We hypothesize that these events are dependent upon DARPP-32 expression. ..
- Structure-function of inositol trisphosphate receptorIlya Bezprozvanny; Fiscal Year: 2009..Dopamine-induced responses in striatal medium spiny neurons will be studied by Ca2+ imaging. Experiments with striatal neurons from DARPP-32 and D2 receptor knockout mice will be performed. ..
- RECEPTORS MEDIATING DRUG DEPENDENCESusan R George; Fiscal Year: 2013....
- WENDY JEAN LYNCH; Fiscal Year: 2016..These studies will provide a much needed foundation for the development of hormonal, pharmacological, and/or molecular based therapeutics for cocaine abuse, especially in women. ..
- Specifying Human iPSC-derived Medium spiny Neurons for Cocaine Abuse ResearchXin Ming Ma; Fiscal Year: 2012..with striatal MSNs, while the iPSC-derived MSNs will be identified by immunostaining with antibodies specific DARPP32, GABA and dopamine receptors (D1R and D2R)...
- Molecular Maladaptations Following Developmental Loss of D1 Receptor SignalingAliya L Frederick; Fiscal Year: 2012..abstract_text> ..
- Role of DARPP-32: Individual Responsiveness to NicotineJun Zhu; Fiscal Year: 2010....
- Paul Greengard; Fiscal Year: 2015..Results from the three Projects will complement each other. In addition, there will be a significant level of collaboration between the three Projects, as well as close interaction of the three Projects with the Scientific Core. ..
- Huntington's Disease and NeurogenesisLisa M Ellerby; Fiscal Year: 2012..We are developing a potential therapy to protect neurons or replace them in Huntington's disease. ..
- REGION SPECIFIC PHOSPHOPROTEINS IN THE BASAL GANGLIAPaul Greengard; Fiscal Year: 2004..Project (Scientific Core) will produce key materials and perform routine required for the other projects. ..
- Cell Type Specific Control of Neuronal SignalingMARTILIAS STEPHEN FARRELL; Fiscal Year: 2012..The completion of this proposal will provide neuroscientists a powerful new tool to exclusively modulate GPCR signaling in specific neuronal populations. ..
- John F Neumaier; Fiscal Year: 2014..We will examine the effects of 5-HT6 receptors on cilia and dendritic morphology, cyclic AMP production, DARPP32 hosphorylation, and gene expression using PCR arrays focusing on key pathways predicted to be sensitive to 5-HT6 ..
- Huntington's Disease and the StriatumMichelle E Ehrlich; Fiscal Year: 2010..Knowledge of striatal-specific transcriptional regulation will also be highly relevant to other diseases of the basal ganglia in which transcriptional dysregulation plays a role. II. ..
- Induction of Striatal Regeneration in Huntington's DiseaseSteven Goldman; Fiscal Year: 2009..The new striatal neurons project to the globus pallidus and adopt a DARPP32/GABAergic/calbindin+ phenotype, characteristic of medium spiny projection neurons...
- CHARACTERIZATION OF A NEURON-SPECIFIC PHOSPHOPROTEINSamuel Gandy; Fiscal Year: 1990....
- Role of Endocannabinoids in Levodopa-Induced DyskinesiasAndrea Giuffrida; Fiscal Year: 2012..The study will identify new and more effective therapeutic strategies for the treatment of levodopa-associated motor complications. ..
- Wael El-Rifai; Fiscal Year: 2016..Upon completion of our studies, the results will have a significant impact on understanding the biology of gastric cancer affecting our diagnostic, prognostic, and possibly clinical management of this disease. ..
- D2 TANTYCYTES IN THE REGULATION OF HPT AXISRONALD LECHAN; Fiscal Year: 2001....
- Translational Genetics and Dopamine Signaling in Sensitivity to AmphetaminesCAMRON BRYANT; Fiscal Year: 2009....
- MESOAMYGDALOID DOPAMINE NEURONS AND ANTIPSYCHOTIC DRUGSClinton Kilts; Fiscal Year: 1993..The effects of chronic antipsychotic drugs administration on the density and functional state of amygdaloid NT receptors will be determined...
- Intrabodies as novel neurological therapeuticsAnne Messer; Fiscal Year: 2010..These approaches should also be generally applicable for other neurodegenerative diseases that result from abnormal protein folding and accumulation, including Alzheimer's, Parkinson's, and prion diseases. ..
- Post-Synaptic Striatal TrkB: Role in the Response to CocaineMichelle Ehrlich; Fiscal Year: 2009..This application is focused on the delineation of the site of action of trkB, and what other molecules regulated by trkB may be implicated in the behavioral responses to cocaine. ..
- CHEMICAL NEUROANATOMY OF DOPAMINOCEPTIVE NEURONSCharles Ouimet; Fiscal Year: 1991....
- INTRACELLULAR MOLECULES OF NICOTINE ADDICTIONNoboru Hiroi; Fiscal Year: 2004..If these molecules turn out to be important for vulnerability to nicotine addiction, this mouse study will provide a solid basis for genetic analysis of human addiction vulnerability. ..
- ONTOGENY OF NEUROADAPTIVE RESPONSES TO PSYCHOSTIMULANTSMichelle Ehrlich; Fiscal Year: 2002..abstract_text> ..
- MECHANISMS OF DOPA-DYSKINESIAS IN PARKINSONIAN MODELSJ Langston; Fiscal Year: 2004..The results of this work will advance our understanding of the molecular mechanism responsible for the debilitating dyskinetic movements which occur as a consequence of long-term L-dopa treatment in Parkinson's disease. ..
- Basal Ganglia Expression of TorsinA in Transgenic MiceMichelle Ehrlich; Fiscal Year: 2005..e. a dopamine agonist. ..
- DOPAMINE/GLUTAMATE AND HYPOXIC INJURY IN NEWBORN BRAINDavid Wilson; Fiscal Year: 2009..This understanding will be the basis for more effective treatment of patients who have been subjected to a period(s) of insufficient oxygen delivery to the brain. ..
- Signaling Mechanisms Underlying Neuroleptic Drug ActionsPaul Greengard; Fiscal Year: 2009..Thus, the proposed studies should provide a detailed knowledge on how neuroleptics affect protein phosphorylation pathways in defined neuronal circuitries. ..
- Huntington's Disease and the StriatumDiane Merry; Fiscal Year: 2006..This will be accomplished by crossing of the already established D9/LacZ mouse with the R6/2 HD mouse model, in which endogenous DARPP-32 is down-regulated. ..
- Molecular Regulation of a Striatal DARPP-32 PhenotypeMichelle Ehrlich; Fiscal Year: 2008....
- PREFRONTAL CORTEX NEUROPHYSIOLOGY AFTER CHRONIC COCAINEFrancis White; Fiscal Year: 2003....
- Structural MR Analyses of Drug Exposed BrainsBarry Kosofsky; Fiscal Year: 2008..By developing and applying such tools we will not only address a clinically important problem, but we will develop methods that will be of general value to others pursuing pediatric neuroimaging studies. ..
- ZEISS LSM 510 NLO CONFOCAL/MULTIPHOTON SYSTEM WITH TIL Chandler; Fiscal Year: 2002..A detailed organizational plan, substantial institutional support, and a long-term maintenance plan will ensure sustained viability and maximal use of the instrument. ..
- DOPAMINE AND RETINAL ADAPTATIONPaul Witkovsky; Fiscal Year: 2001....
- DOPAMINE 2002Kim Neve; Fiscal Year: 2002..The banquet will feature informal talks by 2000 Nobel Prize Laureates, Arvid Carlsson and Paul Greengard, and the opening lecture will be given by Marc Caron, the organizer of Dopamine '94 in Quebec City. ..
- Neuropathology and Pathogenesis of Huntington's DiseaseAnton Reiner; Fiscal Year: 2008..abstract_text> ..
- Characterization of Human Trace Amine ReceptorsKim Neve; Fiscal Year: 2006..TARs encoding full-length receptors are expressed on the cell surface, to identify agonists and antagonists for each TAR subtype, and to identify allelic variants that alter the function or ligand binding of a TAR subtype ..
- Cocaine-Induced Disturbances of Mouse Brain DevelopmentBarry Kosofsky; Fiscal Year: 2003....
- Mouse Behavior Models of Cocaine AddictionFrancis White; Fiscal Year: 2003..The development of these models should allow phenotypic characterization of behaviors related to drug taking and drug seeking and provide novel tests for various transgenic mice. ..
- A PR-Induced Autocrine/Paracrine Pathway in Female BrainEDE APOSTOLAKIS; Fiscal Year: 2004..This will furnish insight into the underlying cellular and molecular mechanisms that produce steroid receptor-dependent disease etiologies and should contribute to the development of new therapeutic strategies. ..
- Hormones Neuronal Phosphoproteins and BehaviorSHAILAJA MANI; Fiscal Year: 2008..These studies will provide information on the PKA/DARPP-32/PP-1 cascade regulation by progesterone and dopamine in mediating reproductive behavior. ..
- Sex, hormones and cocaine self-administrationWendy Lynch; Fiscal Year: 2006..Thus, these studies may provide a basis for the development of novel treatment strategies for cocaine abuse/dependence, particularly in women. ..
- DOPAMINE MODULATION OF LIMBIC CORTICO ACCUMBENS SYSTEMShao Pii Onn; Fiscal Year: 2004..The proposed study is of particular interest with respect to the deficit syndrome in schizophrenia and possibly other mental disorders such as drug addiction associated with negative affect and depression. ..
- Steroid Hormones Regulatory Mechanisms and BehaviorSHAILAJA MANI; Fiscal Year: 2006..Identification of such cross-talk signaling mechanisms will contribute to our understanding of the environmental and internal determinants of hormone-brain-behavior mechanisms. ..