PPP1R13L

Summary

Gene Symbol: PPP1R13L
Description: protein phosphatase 1 regulatory subunit 13 like
Alias: IASPP, NKIP1, RAI, RAI4, relA-associated inhibitor, NFkB interacting protein 1, PPP1R13B-like protein, inhibitor of ASPP protein, inhibitor of apoptosis stimulating protein of p53, protein iASPP, protein phosphatase 1, regulatory (inhibitor) subunit 13 like, retinoic acid induced 4
Species: human

Top Publications

  1. ncbi Prognostic value of autoantibodies against erythrocytes and platelets in chronic lymphocytic leukemia (CLL)
    G De Rossi
    Human Biopathology Dept, University La Sapienza, Rome, Italy
    Tumori 77:100-4. 1991
  2. ncbi Staging and prognosis of chronic lymphocytic leukemia: the Manitoba experience
    B K MacDougall
    Department of Internal Medicine, St. Boniface General Hospital, University of Manitoba, Winnipeg, Canada
    J Gen Intern Med 3:139-43. 1988
  3. ncbi Identification of a novel isoform of iASPP and its interaction with p53
    Xinwei Zhang
    State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin 300020, China
    J Mol Biol 368:1162-71. 2007
  4. doi RNA interference-mediated silencing of iASPP induces cell proliferation inhibition and G0/G1 cell cycle arrest in U251 human glioblastoma cells
    Guilin Li
    Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, People s Republic of China
    Mol Cell Biochem 350:193-200. 2011
  5. doi Abnormal expression pattern of the ASPP family of proteins in human non-small cell lung cancer and regulatory functions on apoptosis through p53 by iASPP
    Shijun Li
    Department of Clinical Laboratory, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, PR China
    Oncol Rep 28:133-40. 2012
  6. ncbi Identification of a novel inhibitor of nuclear factor-kappaB, RelA-associated inhibitor
    J P Yang
    Department of Molecular Genetics, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    J Biol Chem 274:15662-70. 1999
  7. ncbi iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human
    Daniele Bergamaschi
    Ludwig Institute for Cancer Research, Imperial College School of Medicine, St Mary s Campus, Norfolk Place, London, W2 1PG, UK
    Nat Genet 33:162-7. 2003
  8. ncbi The N-terminus of a novel isoform of human iASPP is required for its cytoplasmic localization
    Elizabeth A Slee
    Ludwig Institute for Cancer Research, Imperial College School of Medicine, Norfolk Place, London W2 1PG, UK
    Oncogene 23:9007-16. 2004
  9. ncbi A mutation in NFkB interacting protein 1 results in cardiomyopathy and abnormal skin development in wa3 mice
    Bruce J Herron
    Genetics Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Hum Mol Genet 14:667-77. 2005
  10. ncbi Polymorphisms in RAI and in genes of nucleotide and base excision repair are not associated with risk of testicular cancer
    Magdalena J Laska
    Institute of Human Genetics, University of Aarhus, Bartholin Building, DK 8000 Aarhus C, Denmark
    Cancer Lett 225:245-51. 2005

Research Grants

  1. Topical Microbicide Acceptability
    Alex Carballo Dieguez; Fiscal Year: 2006
  2. ASISH KUMAR GHOSH; Fiscal Year: 2016
  3. An Evaluation of Vaccination Practices of Nursing Home Residents and Staff
    David H Howard; Fiscal Year: 2011
  4. Towards Measures of Lupus Nephritis Activity &Damage for Children
    Hermine I Brunner; Fiscal Year: 2012
  5. HEALTH, QUALITY OF CARE AND NURSING HOME CHOICE
    Andrew Foster; Fiscal Year: 1999
  6. Cyclic nucleotide phosphodiesterases isoforms as novel biomarkers in CLL
    Lingzhi Zhang; Fiscal Year: 2010
  7. A noninvasive optical imaging of retinal amyloid beta deposits in AD patients
    Maya Koronyo-Hamaoui; Fiscal Year: 2013
  8. BEHAVIORAL RESEARCH FOR AIDS PREVENTION IN THAILAND
    Maria Wawer; Fiscal Year: 1993
  9. James A Fagin; Fiscal Year: 2014
  10. Family-to-Family: Psychoeducation to Improve Children's Outcomes in HIV+ Families
    Li Li; Fiscal Year: 2009

Detail Information

Publications194 found, 100 shown here

  1. ncbi Prognostic value of autoantibodies against erythrocytes and platelets in chronic lymphocytic leukemia (CLL)
    G De Rossi
    Human Biopathology Dept, University La Sapienza, Rome, Italy
    Tumori 77:100-4. 1991
    Antiglobulin test (AT) and Dixon tests were performed in 100 patients with CLL. Thirty-five of them had Rai stages 0 or 1, 19 stage 2, 13 stage 3, and 33 stage 4...
  2. ncbi Staging and prognosis of chronic lymphocytic leukemia: the Manitoba experience
    B K MacDougall
    Department of Internal Medicine, St. Boniface General Hospital, University of Manitoba, Winnipeg, Canada
    J Gen Intern Med 3:139-43. 1988
    ..Survival curves were developed using the staging systems of Rai and Binet. A clear separation in survival was found utilizing the system of Binet...
  3. ncbi Identification of a novel isoform of iASPP and its interaction with p53
    Xinwei Zhang
    State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin 300020, China
    J Mol Biol 368:1162-71. 2007
    b>iASPP is an inhibitory member of ASPP (apoptosis stimulating protein of p53, or Ankyrin repeats, SH3 domain and proline-rich region contain Protein) family...
  4. doi RNA interference-mediated silencing of iASPP induces cell proliferation inhibition and G0/G1 cell cycle arrest in U251 human glioblastoma cells
    Guilin Li
    Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, People s Republic of China
    Mol Cell Biochem 350:193-200. 2011
    b>iASPP is an evolutionally conserved inhibitory member of the ASPP (apoptosis-stimulating protein of p53) protein family...
  5. doi Abnormal expression pattern of the ASPP family of proteins in human non-small cell lung cancer and regulatory functions on apoptosis through p53 by iASPP
    Shijun Li
    Department of Clinical Laboratory, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, PR China
    Oncol Rep 28:133-40. 2012
    ..Recently discovered ASPP1 and ASPP2 are specific activators and iASPP is an inhibitor of p53...
  6. ncbi Identification of a novel inhibitor of nuclear factor-kappaB, RelA-associated inhibitor
    J P Yang
    Department of Molecular Genetics, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    J Biol Chem 274:15662-70. 1999
    Here we report the identification and characterization of a novel protein, RelA-associated inhibitor (RAI), that binds to the NF-kappaB subunit p65 (RelA) and inhibits its transcriptional activity...
  7. ncbi iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human
    Daniele Bergamaschi
    Ludwig Institute for Cancer Research, Imperial College School of Medicine, St Mary s Campus, Norfolk Place, London, W2 1PG, UK
    Nat Genet 33:162-7. 2003
    ..Here, we characterize such a protein, iASPP (inhibitory member of the ASPP family), encoded by PPP1R13L in humans and ape-1 in Caenorhabditis elegans...
  8. ncbi The N-terminus of a novel isoform of human iASPP is required for its cytoplasmic localization
    Elizabeth A Slee
    Ludwig Institute for Cancer Research, Imperial College School of Medicine, Norfolk Place, London W2 1PG, UK
    Oncogene 23:9007-16. 2004
    ..b>iASPP(RAI) is a third member of the family that is the most conserved inhibitor of p53-mediated apoptosis...
  9. ncbi A mutation in NFkB interacting protein 1 results in cardiomyopathy and abnormal skin development in wa3 mice
    Bruce J Herron
    Genetics Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Hum Mol Genet 14:667-77. 2005
    ..A C-terminal fragment of this protein was previously identified as the RelA associated inhibitor (RAI)...
  10. ncbi Polymorphisms in RAI and in genes of nucleotide and base excision repair are not associated with risk of testicular cancer
    Magdalena J Laska
    Institute of Human Genetics, University of Aarhus, Bartholin Building, DK 8000 Aarhus C, Denmark
    Cancer Lett 225:245-51. 2005
    ..2-3, encompassing the genes ASE, ERCC1, RAI and XPD, were associated with risk of testicular cancer in Danish patients...
  11. ncbi Gene-environment interactions between smoking and a haplotype of RAI, ASE-1 and ERCC1 polymorphisms among women in relation to risk of lung cancer in a population-based study
    Ulla Vogel
    National Institute of Occupational Health, Lersø Parkallé 105, DK 2100 Copenhagen, Denmark
    Cancer Lett 247:159-65. 2007
    Homozygous carriers of a haplotype consisting of ERCC1 Asn118Asn(A), ASE-1 G-21A(G), RAI IVS1 A4364G(A) are at increased risk of lung cancer especially among women...
  12. pmc Effects of polymorphisms in ERCC1, ASE-1 and RAI on the risk of colorectal carcinomas and adenomas: a case control study
    Camilla F Skjelbred
    Department of Laboratory Medicine, Section of Medical Genetics, Telemark Hospital, N 3710 Skien, Norway
    BMC Cancer 6:175. 2006
    ..In this study, we aimed to evaluate whether the recently identified haplotype encompassing genes of DNA repair and apoptosis, is associated with increased risk of colorectal adenomas and carcinomas...
  13. ncbi iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53
    Daniele Bergamaschi
    Ludwig Institute for Cancer Research, University College London, 91 Riding House Street, London W1W 7BS, UK
    Nat Genet 38:1133-41. 2006
    b>iASPP is one of the most evolutionarily conserved inhibitors of p53, whereas ASPP1 and ASPP2 are activators of p53...
  14. ncbi Polymorphisms in the genes ERCC2, XRCC3 and CD3EAP influence treatment outcome in multiple myeloma patients undergoing autologous bone marrow transplantation
    Annette Vangsted
    Department of Haematology, Herlev University Hospital of Copenhagen, DK 2730 Herlev, Denmark
    Int J Cancer 120:1036-45. 2007
    ..overall survival (OS) of polymorphism in the DNA repair genes ERCC1, ERCC2 and XRCC3, and in the apoptotic genes PPP1R13L and CD3EAP in 348 patients with multiple myeloma undergoing autologous bone marrow transplantation...
  15. ncbi Genetic polymorphisms and treatment response in advanced non-small cell lung cancer
    Dan Su
    Department of Epidemiology and Public Health, Yale Cancer Center, Yale University School of Medicine, 60 College Street, New Haven, CT 06520 8034, USA
    Lung Cancer 56:281-8. 2007
    ..we genotyped four single nucleotide polymorphisms (SNPs) in ATM (A60G), ERCC1 (Asn118Asn), APE1 (Asn148Glu), and iASPP (A67T), and examined their associations with treatment response among patients with advanced non-small cell lung ..
  16. ncbi Expression of the RAI gene is conducive to apoptosis: studies of induction and interference
    Magdalena J Laska
    Institute of Human Genetics, Bartholin Building, University of Aarhus, DK 8000 Aarhus C, Denmark
    Exp Cell Res 313:2611-21. 2007
    The RAI gene is also known as iASPP and PPP1R13L. Recent investigations have shown that the region encompassing RAI is important for the development of cancer in young and middle-aged persons...
  17. doi Biochemical and structural studies of ASPP proteins reveal differential binding to p53, p63, and p73
    Ross Alexander Robinson
    Cancer Research UK Receptor Structure Research Group, Division of Structural Biology, Henry Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom
    Structure 16:259-68. 2008
    ASPP1 and ASPP2 are activators of p53-dependent apoptosis, whereas iASPP is an inhibitor of p53...
  18. pmc A haplotype of polymorphisms in ASE-1, RAI and ERCC1 and the effects of tobacco smoking and alcohol consumption on risk of colorectal cancer: a Danish prospective case-cohort study
    Rikke D Hansen
    National Research Centre for the Working Environment, Lersø Parkallé 105, 2100 Copenhagen, Denmark
    BMC Cancer 8:54. 2008
    ..The haplotype at chromosome 19q13.2-3 encompassing the three SNPs ASE-1 G-21A, RAI IVS1 A4364G and ERCC1 Asn118Asn have been associated with risk of breast cancer and lung cancer...
  19. doi Effect of RNA interference of iASPP on the apoptosis in MCF-7 breast cancer cells
    Ze Jun Liu
    Laboratory of International Cooperation, Southwest Hospital, Third Military Medical University, Chongqing, PRC
    Cancer Invest 26:878-82. 2008
    ASPP family is proved to be apoptotic specific regulators of p53. Among them, iASPP acts as an inhibitor of p53...
  20. pmc Insight into the structural basis of pro- and antiapoptotic p53 modulation by ASPP proteins
    Jinwoo Ahn
    Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA
    J Biol Chem 284:13812-22. 2009
    ..Its three known members, ASPP1, ASPP2, and iASPP, were previously found to interact with p53, influencing the apoptotic response of cells without affecting p53-..
  21. ncbi Down-regulation of iASPP in human hepatocellular carcinoma cells inhibits cell proliferation and tumor growth
    B L Lin
    Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yet sen University, Tianhe Area, 600 Tianhe, Guangzhou 510060, Guangdong Province, China
    Neoplasma 58:205-10. 2011
    The oncoprotein inhibitory member of the ASPP family (iASPP) is a key inhibitor of the p53 tumor suppressor and is upregulated in patients with acute leukemia and breast carcinoma...
  22. doi Inhibitory member of the apoptosis-stimulating protein of p53 (ASPP) family promotes growth and tumorigenesis in human p53-deficient prostate cancer cells
    B Zhang
    Department of Infertility and Sexual Medicine, The Third Affiliated Hospital of Sun Yat Sen University, Guangzhou, China
    Prostate Cancer Prostatic Dis 14:219-24. 2011
    b>iASPP is a member of the apoptosis-stimulating protein of p53 (ASPP) family and an evolutionarily conserved inhibitor of p53...
  23. doi Molecular mechanisms underlying the interaction of protein phosphatase-1c with ASPP proteins
    Tamara D Skene-Arnold
    Department of Biochemistry, 3 37 Medical Sciences Building, School of Translational Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada, T6G 2H7
    Biochem J 449:649-59. 2013
    ..Human ASPPs (apoptosis-stimulating proteins of p53) comprise three family members: ASPP1, ASPP2 and iASPP (inhibitory ASPP), which is uniquely overexpressed in many cancers...
  24. pmc RelA-associated inhibitor blocks transcription of human immunodeficiency virus type 1 by inhibiting NF-kappaB and Sp1 actions
    Norio Takada
    Department of Molecular Genetics, Nagoya City University Medical School, Japan
    J Virol 76:8019-30. 2002
    RelA-associated inhibitor (RAI) is an inhibitor of nuclear factor kappaB (NF-kappaB) newly identified by yeast two-hybrid screen as an interacting protein of the p65 (RelA) subunit...
  25. ncbi The expression of iASPP in acute leukemias
    Xinwei Zhang
    Department of Clinical Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 288 Nanjing Road, Tianjin 300020, P R China
    Leuk Res 29:179-83. 2005
    Inhibitory member of the ASPP family (iASPP) is an evolutionarily conserved inhibitor of p53, and its expression is upregulated in human breast carcinomas expressing wild-type p53...
  26. pmc Linkage disequilibrium mapping of a breast cancer susceptibility locus near RAI/PPP1R13L/iASPP
    Bjørn A Nexø
    Institute of Human Genetics, University of Aarhus, DK 8000 Aarhus C, Denmark
    BMC Med Genet 9:56. 2008
    ..The study groups included 434 postmenopausal breast cancer cases and an identical number of individually matched controls...
  27. ncbi Fluorescence in situ hybridization detection of cytogenetic abnormalities in B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma
    Patricia Aoun
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 3135, USA
    Leuk Lymphoma 45:1595-603. 2004
    ..Clinical staging of B-CLL patients showed that 70% of the patients were Rai stage 0, 1, or 2, and 30% stage 3 or 4...
  28. ncbi [Changes in adrenal cortex function and protective effect of dexamethasone in septic rats during early phases]
    Zhen jie Hu
    Intensive Care Unit, Forth Hospital Affiliated to Hebei Medical University, Shijiazhuang 050011, Hebei, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 21:40-3. 2009
    To affirm the presence of relative adrenal insufficiency (RAI) in the early phases of sepsis and its probable mechanisms, and to study the optimal time for glucocorticoid replacement therapy.
  29. ncbi Treatment with lithium prevents serum thyroid hormone increase after thionamide withdrawal and radioiodine therapy in patients with Graves' disease
    Fausto Bogazzi
    Department of Endocrinology and Metabolism, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 87:4490-5. 2002
    Serum thyroid hormone concentrations increase after radioiodine (RAI) therapy for Graves' disease...
  30. ncbi Altered arterial homeostasis and cerebral aneurysms: a molecular epidemiology study
    Amin B Kassam
    Department of Neurosurgery, University of Pittsburgh, Pennsylvania, USA
    Neurosurgery 54:1450-60; discussion 1460-2. 2004
    ..In this study, we undertook a preliminary assessment of differential expression of key molecules involved with each phase of homeostasis: arterial flow modulation, arterial tear and repair, and the ensuing extracellular matrix...
  31. ncbi Septic shock and sepsis: a comparison of total and free plasma cortisol levels
    J T Ho
    Hanson Institute, The University of Adelaide, Adelaide, Australia
    J Clin Endocrinol Metab 91:105-14. 2006
    ..after tetracosactrin have been associated with increased mortality and hemodynamic responsiveness to exogenous hydrocortisone in septic shock (SS), a phenomenon termed by some investigators as relative adrenal insufficiency (RAI).
  32. ncbi Insecticide susceptible/resistance status in Aedes (Stegomyia) aegypti and Aedes (Stegomyia) albopictus (Diptera: Culicidae) in Thailand during 2003-2005
    Nuananong Jirakanjanakit
    Center for Vaccine Development, Institute of Science and Technology for Research and Development, Mahidol University, Salaya, Puttamonthon, Nakhonpathom, Thailand
    J Econ Entomol 100:545-50. 2007
    ..to deltamethrin and permethrin, except those from some areas of Songkhla (southern) and Phan district of Chiang Rai (northern) province...
  33. ncbi Risk adjustment of quality indicators in French long term care facilities for elderly people. A preliminary study
    C Moty
    Centre Hospitalier Universitaire de Bordeaux, Unité INSERM 593 ex 330, Institut de Santé Publique, d Épidémiologie et de Développement, Universite Victor Segalen Bordeaux 2, rue Leo Saignat, 33076 Bordeaux Cedex, France
    Rev Epidemiol Sante Publique 51:327-38. 2003
    ..The objective of this preliminary study was to propose risk adjustments on the CHSRA indicators for future use in France...
  34. ncbi Radioiodine treatment of hyperthyroidism: prognostic factors affecting outcome
    Cihangir Erem
    Department of Internal Medicine, Division of Endocrinology and Metabolism, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey
    Endocrine 25:55-60. 2004
    To assess the effectiveness of radioactive iodine (RAI) treatment in patients with hyperthyroidism and to evaluate prognostic factors affecting outcome.
  35. pmc Clinicoprognostic implications of increased serum levels of vascular endothelial growth factor and basic fibroblastic growth factor in early B-cell chronic lymphocytic leukaemia
    S Molica
    Department of Hematology, Azienda Ospedaliera Pugliese Ciaccio, Catanzaro, Italy
    Br J Cancer 86:31-5. 2002
    ..Serum levels of vascular endothelial growth factor positively correlated with Rai sub-stages (P=0.03), peripheral blood lymphocytosis (P=0.03), bone marrow histology (P=0...
  36. ncbi Adaptive servoventilation versus noninvasive positive pressure ventilation for central, mixed, and complex sleep apnea syndromes
    Timothy I Morgenthaler
    Mayo Clinic Sleep Disorders Center, 200 First Street SW, Rochester, MN 55905, USA
    Sleep 30:468-75. 2007
    ....
  37. doi Long-term outcome of twin atrioventricular node and supraventricular tachycardia in patients with right isomerism of the atrial appendage
    Mei Hwan Wu
    Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    Heart Rhythm 5:224-9. 2008
    Twin AV nodes and resulting supraventricular tachycardia (SVT) have been described in right atrial isomerism (RAI).
  38. ncbi The Rheumatology Attitudes Index and its helplessness subscale are valid and reliable measures of learned helplessness in Asian patients with systemic lupus erythematosus
    J Thumboo
    Department of Rheumatology and Immunology, Tan Tock Seng Hospital, Singapore, Singapore
    J Rheumatol 26:1512-7. 1999
    To assess the internal consistency, reliability, and construct validity of the Rheumatology Attitudes Index (RAI) and its subscales in a cohort of Asian patients with systemic lupus erythematosus (SLE).
  39. ncbi Characterization of thyroid-stimulating blocking antibodies that appeared during transient hypothyroidism after radioactive iodine therapy
    A W Kung
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Thyroid 10:909-17. 2000
    Hypothyroidism after radioactive iodine (RAI) therapy for Graves' disease can be transient or permanent. The cause for early transient hypothyroidism is unknown...
  40. ncbi Use of antipsychotics in older home care patients in Finland
    Hanna Mari Alanen
    Medical School, University of Tampere, Tampere, Finland
    Drugs Aging 25:335-42. 2008
    ..To investigate the use of antipsychotic medications, and factors associated with such use, in elderly patients in home care in Finland...
  41. ncbi A phase II study of DT fusion protein denileukin diftitox in patients with fludarabine-refractory chronic lymphocytic leukemia
    Arthur E Frankel
    Wake Forest University Baptist Medical Center, Winston Salem, North Carolina 27157, USA
    Clin Cancer Res 9:3555-61. 2003
    ..We tested the safety and efficacy in these patients of a diphtheria fusion protein DAB(389)IL2 (denileukin diftitox) directed against the interleukin 2 receptor that is expressed by CLL cells...
  42. ncbi Evaluation of the surgical completeness after total thyroidectomy for differentiated thyroid carcinoma
    M Salvatori
    Institute of Nuclear Medicine, Universita Cattolica del S Cuore, Rome, Italy
    Eur J Surg Oncol 33:648-54. 2007
    ....
  43. ncbi The comparative effects of gene modulators on thyroid-specific genes and radioiodine uptake
    Murat Tuncel
    Department of Nuclear Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Cancer Biother Radiopharm 22:281-8. 2007
    ..thyroglobulin (Tg), thyroid peroxidase (TPO), and thyroid stimulating hormone receptor (TSH-R), and radioiodine (RAI) uptake in cancer (B-CPAP) and normal (Nthy-ori 3-1) thyroid cell lines...
  44. ncbi The comparative effects of gene modulators on thyroid-specific genes and radioiodine uptake
    Murat Tuncel
    Department of Nuclear Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Cancer Biother Radiopharm 22:443-9. 2007
    ..Tg), thyroid peroxidase (TPO), and the thyroid-stimulating hormone receptor (TSH-R), as well as radioiodine (RAI) uptake in cancer (B-CPAP) and normal (Nthy-ori 3-1) thyroid cell lines...
  45. doi Rosiglitazone effect on radioiodine uptake in thyroid carcinoma patients with high thyroglobulin but negative total body scan: a correlation with the expression of peroxisome proliferator-activated receptor-gamma
    Supatporn Tepmongkol
    Division of Nuclear Medicine, Department of Radiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    Thyroid 18:697-704. 2008
    ..with high thyroglobulin (Tg) level but negative total body scan (TBS) are difficult to treat with radioiodine (RAI)...
  46. doi High prevalence of side effects after recombinant human thyrotropin-stimulated radioiodine treatment with 30 mCi in patients with multinodular goiter and subclinical/clinical hyperthyroidism
    Rossana Romão
    Thyroid Unit LIM 25, Division of Endocrinology, University of Sao Paulo Medical School, Hospital das Clinicas, Sao Paulo, Brazil
    Thyroid 19:945-51. 2009
    Treatment of multinodular goiters (MNGs) is highly controversial. Radioiodine (RAI) therapy is a nonsurgical alternative for the elderly who decline surgery...
  47. ncbi The yeast RNA1 protein, necessary for RNA processing, is homologous to the human ribonuclease/angiogenin inhibitor (RAI)
    R Schneider
    , , Austria
    Mol Gen Genet 233:315-8. 1992
    ..Within this superfamily RNA1 is most closely related to the ribonuclease/angiogenin inhibitor (RAI), which is a tightly binding inhibitor of ribonucleolytic activities in mammals...
  48. ncbi Review of nursing documentation in nursing home wards - changes after intervention for individualized care
    G Hansebo
    Department of Clinical Neuroscience and Family Medicine, Division of Geriatric Medicine, Karolinska Institute, Stockholm, Sweden
    J Adv Nurs 29:1462-73. 1999
    ..The Resident Assessment Instrument/Minimum Data Set (RAI/MDS) especially developed for the care of elderly people, was used as a basis for individualized and documented ..
  49. pmc Circulating proangiogenic cytokines and angiogenesis inhibitor endostatin in untreated patients with chronic lymphocytic leukemia
    Joanna Gora-Tybor
    Department of Hematology, Medical University of Lodz, ul Pabianicka 62 93 513 Lódz, Poland
    Mediators Inflamm 12:167-71. 2003
    ..5 pg/ml and 40.5 pg/ml respectively) (p<0.001). Patients in Rai stage III and IV also had significantly higher levels of bFGF than patients in Rai stage 0-II (median 100...
  50. ncbi Direct nasopharyngeal reflux of gastric acid is a contributing factor in refractory chronic rhinosinusitis
    John M DelGaudio
    Department of Otolaryngology Head and Neck Surgery, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Laryngoscope 115:946-57. 2005
    ..It is hypothesized that refractory CRS patients have a greater incidence of laryngopharyngeal reflux and NPR events and that NPR is a significant etiologic factor for CRS in these patients...
  51. ncbi Molecular basis of aggressive disease in chronic lymphocytic leukemia patients with 11q deletion and trisomy 12 chromosomal abnormalities
    Amit K Mittal
    Department of Genetics, University of Nebraska Medical Center, Omaha, NE 68198 6395, USA
    Int J Mol Med 20:461-9. 2007
    In B-cell chronic lymphocytic leukemia (CLL), Rai stage, immunoglobulin gene mutational status, chromosomal abnormalities, CD38 and ZAP-70 expression were used as prognostic markers...
  52. doi The ecological complexity of the Thai-Laos Mekong River: III. Health status of Mekong catfish and cyprinids, evidence of bioaccumulative effects
    Kantimanee Phanwichien
    Faculty of Science, Kasetsart University, Chatujak, Bangkok, Thailand
    J Environ Sci Health A Tox Hazard Subst Environ Eng 45:1681-8. 2010
    ..comprising of 52 cyprinids and 65 catfishes were randomly collected from the Mekong River from 5 stations: Chiang Rai, Loei, Nongkhai, Nakhon Phanom and Ubonratchathani...
  53. ncbi Elevated serum levels of soluble CD44 can identify a subgroup of patients with early B-cell chronic lymphocytic leukemia who are at high risk of disease progression
    S Molica
    Divisione Ematologia e Oncologia Clinica, Azienda Ospedaliera Pugliese Ciaccio, Via Pio X, 88100 Catanzaro, Italy
    Cancer 92:713-9. 2001
    ....
  54. ncbi Evaluation of methods of resynchronization for insemination in cows of unknown pregnancy status
    K N Galvao
    Veterinary Medicine Teaching and Research Center, University of California Davis, Tulare 93274, USA
    J Dairy Sci 90:4240-52. 2007
    ..treatment until diagnosed as pregnant, which resulted in a total of 1,148 AI (495 PAI and 653 resynchronized AI; RAI)...
  55. ncbi Genes of Rhodobacter sphaeroides 2.4.1 regulated by innate quorum-sensing signal, 7,8-cis-N-(tetradecenoyl) homoserine lactone
    Won Hwang
    Department of Life Science and Interdisciplinary Program of Integrated Biotechnology, Sogang University, Seoul 121 742, Korea
    J Microbiol Biotechnol 18:219-27. 2008
    ..different level of beta- gal activities upon the addition of synthetic 7,8-cis-Ntetradecenoyl- homoserine lactone (RAI)...
  56. ncbi Relative adrenal insufficiency among trauma patients in a community hospital
    Brian R Beeman
    Department of Surgery, Synergy Medical Education Alliance, 1000 Houghton Avenue, Saginaw, MI 48603, USA
    Curr Surg 62:633-7. 2005
    ..Recent studies have proven that low doses of hydrocortisone and fludrocortisone can significantly reduce mortality in patients with relative adrenal insufficiency (RAI) without increasing adverse events.
  57. ncbi Cinedefecographic findings in patients with obstructed defecation sindrome. A study in 420 cases
    A Renzi
    Colorectal Surgery Unit, S Stefano Hospital, and Division of General Surgery, Federico II University, Naples, Italy
    Minerva Chir 61:493-9. 2006
    ..Obstructed defecation syndrome (ODS) represents a very common clinical problem. The aim of this study was to analyze the cinedefecographic findings in a group of patients with ODS...
  58. pmc The cin and rai quorum-sensing regulatory systems in Rhizobium leguminosarum are coordinated by ExpR and CinS, a small regulatory protein coexpressed with CinI
    Anne Edwards
    John Innes Centre, Norwich Research Park, Colney, Norwich NR47UH, United Kingdom
    J Bacteriol 191:3059-67. 2009
    ..We conclude that CinS mediates quorum-sensing regulation because it is coregulated with an AHL synthase and demonstrate that its regulatory effects can occur in the absence of AHLs...
  59. doi Serum level of CD26 predicts time to first treatment in early B-chronic lymphocytic leukemia
    Stefano Molica
    Medical Oncology Unit, Hematology Oncology Department, Azienda Ospedaliera Pugliese Ciaccio, Viale Pio X 88100 Catanzaro, Italy
    Eur J Haematol 83:208-14. 2009
    ..07) and CD38 (P = 0.08), circulating levels of CD26 did not correlate with either Rai substages (P = 0.520) or other biomarker [beta2-microglobulin (P = 0.933), LDH (P = 0...
  60. ncbi Patient misconceptions and ethical challenges in radioactive iodine scanning and therapy
    M Sara Rosenthal
    Program for Bioethics and Patients Rights, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0086, USA
    J Nucl Med Technol 34:143-50; quiz 151-2. 2006
    The use and nature of radioactive iodine (RAI) are complex topics for patients with thyroid conditions to understand...
  61. ncbi A single unit lymphoma experience: outcome in a Cape Town academic centre
    Lucille Wood
    The Department of Haematology and Bone Marrow Transplant Unit, Incorporating The Searll Research Laboratory for Cellular and Molecular Biology, Constantiaberg Medi Clinic, Plumstead, Cape Town, South Africa
    Transfus Apher Sci 37:93-102. 2007
    ..or high-grade histopathology, risk factors defined by the International Prognostic Index as well as late Rai stages...
  62. doi [Developing and testing quality indicators of home care in Switzerland]
    L Burla
    Fachstelle Gesundheitswissenschaften, Departement Gesundheit, ZHAW Zürcher Hochschule für Angewandte Wissenschaften, Winterthur, Schweiz
    Gesundheitswesen 72:106-13. 2010
    ..this study was to develop and examine quality indicators of home care in Switzerland using the Swiss version of the RAI-HC (Resident Assessment Instrument Home Care)...
  63. doi Impact of lithium on efficacy of radioactive iodine therapy for Graves' disease: a cohort study on cure rate, time to cure, and frequency of increased serum thyroxine after antithyroid drug withdrawal
    Fausto Bogazzi
    Department of Endocrinology and Metabolism, and Epidemiology and Biostatistics Unit G R, Institute of Clinical Physiology, National Research Council, 56124 Pisa, Italy
    J Clin Endocrinol Metab 95:201-8. 2010
    Radioactive iodine (RAI) is a common therapy for hyperthyroidism due to Graves' disease. A small but significant proportion of patients have recurrence of hyperthyroidism after RAI therapy...
  64. ncbi Normalization of serum thyrotrophin by means of radioiodine treatment in subclinical hyperthyroidism: effect on bone loss in postmenopausal women
    J Faber
    Department of Endocrinology E, Frederiksberg Hospital, Denmark
    Clin Endocrinol (Oxf) 48:285-90. 1998
    ....
  65. ncbi [Telomere length and telomerase expression activity in mononuclear cells of patients with chronic lymphocytic leukemia]
    Lan Ma
    Department of Hematology, Peking University Third Hospital, Beijing 100191, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 17:1409-12. 2009
    ..There was statistical significant difference between Rai stages III-IV and stage 0, Rai stages III-IV and stages I-II, Binet stage C and stage A, Binet stage C and stage B; ..
  66. ncbi Radioiodine treatment of hyperthyroidism. Success rate and influence of thyrostatic medication
    Wisam K Ghadban
    Department of Endocrinology Metabolism and Internal Medicine, Hamad Medical Corporation, PO Box 3050, Doha, Qatar
    Saudi Med J 24:347-51. 2003
    The aim of this study is to evaluate the response rate of hyperthyroidism to radioactive iodine (RAI) treatment, optimum effective dose, effect of pretreatment with thyrostatic medications, etiology, ophthalmopathy, mortality and cancer ..
  67. ncbi Long-term course and predictive factors of elevated serum thyroglobulin and negative diagnostic radioiodine whole body scan in differentiated thyroid cancer
    A S Alzahrani
    Department of Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    J Endocrinol Invest 28:540-6. 2005
    ..thyroid cancer (DTC) develop a state of high thyroglobulin (Tg) and negative diagnostic radioactive iodine (RAI) whole body scan (DxWBS). The predisposing factors and outcome of this condition are unclear...
  68. ncbi Radioactive iodine therapy for goitrous Hashimoto's thyroiditis
    Junichi Tajiri
    Tajiri Thyroid Clinic, 2 6 20 Suizenji, Kumamoto 862 0950, Japan
    J Clin Endocrinol Metab 91:4497-500. 2006
    ..Hashimoto's thyroiditis is an autoimmune disease that can produce marked clinical symptoms when patients have large diffuse goiters...
  69. ncbi Induction of stimulating thyrotropin receptor antibodies after radioiodine therapy for toxic multinodular goitre and Graves' disease measured with a novel bioassay
    Guido C Hovens
    Department of Endocrinology, Leiden University Medical Center, Leiden, Netherlands
    Nucl Med Commun 28:123-7. 2007
    Radioactive iodine therapy (RaI) in toxic multinodular goitre (TMNG) has been associated with the occurrence of Graves'-like hyperthyroidism. It has been postulated that pre-existing autoimmunity may contribute to this phenomenon.
  70. doi Radioiodine therapy (RAI) for Graves' disease (GD) and the effect on ophthalmopathy: a systematic review
    Shamasunder H Acharya
    Department of Endocrinology, Wards 27 28, Aberdeen Royal Infirmary, Aberdeen, Scotland, UK
    Clin Endocrinol (Oxf) 69:943-50. 2008
    An association between radioiodine therapy (RAI) for Graves' disease (GD) and the development or worsening of Graves' ophthalmopathy (GO) is widely quoted but there has been no systematic review of the evidence.
  71. doi Influence of methimazole and radioactive iodine treatment in the serum levels of the chemokine CXCL10 in hyperthyroid patients with Graves' disease
    A C Leite
    Endocrinology Division, Hospital do Servidor Publico Estadual de São Paulo IAMSPE, Sao Paulo, SP, Brazil
    Horm Metab Res 43:194-9. 2011
    ..diagnosed GD patients received methimazole (MMI), 15 relapsed GD patients were treated with radioactive iodine (RAI), and 18 healthy subjects served as a control group...
  72. ncbi Defining malnutrition risk for older home care clients
    Mary Ann Bocock
    Department of Family Relations and Applied Human Nutrition, University of Guelph, Guelph, Ontario, Canada
    Can J Diet Pract Res 69:171-6. 2008
    The Resident Assessment Instrument-Home Care (RAI-HC) is widely used to assess needs of home care clients and includes five items used to screen for malnutrition...
  73. ncbi Nursing working conditions in relation to restraint practices in long-term care units
    Laura Pekkarinen
    National Research and Development Centre for Welfare and Health STAKES, Helsinki, Finland
    Med Care 44:1114-20. 2006
    ..This study examined the effects of nursing working conditions on the use of physical restraints and antipsychotics as restraints in long-term care units for elderly residents...
  74. ncbi [The effect of propylthiouracil on the efficacy of radioiodine (I-131) therapy in graves hyperthyroidism]
    Marcus V L de Souza
    Servico de Endocrinologia, Departamento de Ciencias Médicas, Universidade Federal do Rio de Janeiro
    Arq Bras Endocrinol Metabol 50:1088-95. 2006
    Aiming at evaluating the effect of antithyroid drugs on the efficacy of radioiodine treatment (RAI) we retrospectively analyzed 226 patients with Graves disease hyperthyroidism submitted to RAI between 1990 and 2001: 58 patients without ..
  75. ncbi Clinical progression and outcome of patients with monoclonal B-cell lymphocytosis
    Sarah S Fung
    Faculty of Medicine, University of British Columbia, BC, Canada
    Leuk Lymphoma 48:1087-91. 2007
    ..We performed a retrospective analysis of patients with MBL (n = 46), Rai stage 0 CLL (n = 112) and Rai stage > or =1 CLL (n = 54). Median follow-up and range was 30 (0...
  76. ncbi Use of antipsychotic medications in older home-care patients. Report from nine European countries
    Hanna Mari Alanen
    University of Tampere, Medical School, FIN 33014 Tampere, Finland
    Aging Clin Exp Res 20:260-5. 2008
    ..Data on the use of antipsychotics among older people in need of regular home care services are rare. The aim of this study was to ascertain the differences in the use and type of antipsychotic medications between European home-care sites...
  77. doi Improved current era outcomes in patients with heterotaxy syndromes
    Petros V Anagnostopoulos
    Pediatric Heart Center, The Phoenix Children s Hospital, Phoenix, AZ 85006, USA
    Eur J Cardiothorac Surg 35:871-7; discussion 877-8. 2009
    ..We sought to assess whether current era management strategies have improved outcomes in patients with visceral heterotaxy...
  78. doi HLA-G expression in B chronic lymphocytic leukemia: a new prognostic marker?
    Alev Akyol Erikci
    Department of Hematology, Gulhane Military Hospital, Istanbul Ankara, Turkey
    Hematology 14:101-5. 2009
    ..Classical Rai and Binet staging of CLL is being superseded by new prognostic markers...
  79. ncbi Natural history of early chronic lymphocytic leukemia. A single institution study with emphasis on the impact of disease-progression on overall survival
    S Molica
    Divisione Ematologia, Azienda Ospedaliera Pugliese Ciaccio, Viale Pio X, 88100 Catanzaro, Italy
    Haematologica 84:1094-9. 1999
    ..Is not clear whether these same criteria apply to patients followed-up in the setting of clinical practice. With the aim of addressing this issue we investigated the clinical outcome of a series of patients with Binet stage A CLL...
  80. pmc Serum levels of IL-6 type cytokines and soluble IL-6 receptors in active B-cell chronic lymphocytic leukemia and in cladribine induced remission
    T Robak
    Department of Hematology, Medical University of Lodz, Copernicus Hospital, Poland
    Mediators Inflamm 8:277-86. 1999
    ..We have correlated the serum levels of these proteins with Rai's clinical stage of the disease, the response to 2-CdA treatment and some hematological parameters...
  81. ncbi Potential for Anopheles campestris (Diptera: Culicidae) to transmit malaria parasites in Pa Rai subdistrict (Aranyaprathet, Sa Kaeo Province), Thailand
    Chamnarn Apiwathnasor
    Department of Medical Entomology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    J Med Entomol 39:583-6. 2002
    ..Anopheles barbirostris and Anopheles campestris Reid are the suspected vectors of Plasmodium vivax in Pa Rai (Aranyaprathet, Sa Kaeo province). To determine if An. barbirostris, An...
  82. ncbi [Chronic lymphocytic leukemia--the old and the new]
    W Korte
    Institut für klinische Chemie und Hämatologie, Kantonsspital, St Gallen
    Ther Umsch 61:151-6. 2004
    ..Prognostic features comprise the stage of the disease according to the Rai or Binet systems, laboratory markers such as LDH, beta-2-microglobulin, lymphocyte doubling time and CD38 ..
  83. ncbi Gemcitabine does not prevent acute rejection of the transplanted liver in rats
    Hynek Mergental
    Department of Transplant Surgery, Institute for Clinical and Experimental Medicine, Videnska 1958 9, 140 21, Prague, Czech Republic
    Transpl Int 17:687-91. 2005
    ..On day 7, blood samples and liver graft tissue specimens were harvested. Group A showed severe rejection changes (RAI 8/9); in group B no rejection changes were present (RAI 0/9), and in group C moderate rejection changes were ..
  84. ncbi Human recombinant TSH preceding a therapeutic dose of radioiodine for multinodular goiters has no significant effect in the surge of TSH-receptor and TPO antibodies
    Ileana G S Rubio
    Thyroid Unit, Division of Endocrinology, Department of Medicine, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Thyroid 15:134-9. 2005
    Radioiodine (RAI) treatment has increasingly been used mostly in elderly patients with multinodular goiter (MNG) as an alternative for surgery...
  85. ncbi Effectiveness of radioiodine (131-I) as definitive therapy in patients with autoimmune and non-autoimmune hyperthyroidism
    B Tarantini
    Section of Endocrinology and Metabolism, Department of Internal Medicine, Endocrinology and Metabolism and Biochemistry, University of Siena, 53100 Siena, Italy
    J Endocrinol Invest 29:594-8. 2006
    We evaluated the outcome of radioiodine (RAI) therapy in 100 consecutive patients treated in the period 2000-2001 for hyperthyroidism due to Graves' disease (GD), toxic adenoma (TA) and toxic multinodular goiter (TMG)...
  86. ncbi Using smudge cells on routine blood smears to predict clinical outcome in chronic lymphocytic leukemia: a universally available prognostic test
    Grzegorz S Nowakowski
    Division of Hematology, College of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Mayo Clin Proc 82:449-53. 2007
    Recently developed prognostic tests in early Rai and Binet stage chronic lymphocytic leukemia (CLL) require considerable technologic expertise and are not available worldwide. Smudge cells are CLL cells ruptured during smear preparation...
  87. ncbi Peripheral blood levels of thyroglobulin mRNA and serum thyroglobulin concentrations after radioiodine ablation of multinodular goiter with or without pre-treatment with recombinant human thyrotropin
    I G S Rubio
    Thyroid Unit LIM 25, Division of Endocrinology, Department of Medicine, University of Sao Paulo Medical School, Sao Paulo, Brazil
    J Endocrinol Invest 30:535-40. 2007
    We investigated the effect of therapeutic doses of radioiodine (RAI) on peripheral serum messenger thyroglobulin RNA (Tg mRNA) and serum thyroglobulin (sTg) in patients with multinodular goiter (MNG) preceded or not by treatment with ..
  88. ncbi Using the Resident Assessment Instrument-Mental Health (RAI-MH) to determine levels of care for individuals with serious mental illness
    Carrie Gibbons
    Lakehead Psychiatric Hospital, St Joseph s Care Group, 580 North Algoma Street, Thunder Bay, Ontario, Canada
    J Behav Health Serv Res 35:60-70. 2008
    ..The algorithm, drew on several domains of the Resident Assessment Instrument-Mental Health (RAI-MH) to support a statistical model that would explain a maximum of variance with the gold standard, a consensus-..
  89. pmc De novo deletion 17p13.1 chronic lymphocytic leukemia shows significant clinical heterogeneity: the M. D. Anderson and Mayo Clinic experience
    Constantine S Tam
    Leukemia Department, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Blood 114:957-64. 2009
    ..Risk factors for progressive disease were Rai stage of 1 or higher and unmutated immunoglobulin variable region heavy chain (IgVH)...
  90. doi Survival impact of treatment options for papillary microcarcinoma of the thyroid
    Harrison W Lin
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, U S A
    Laryngoscope 119:1983-7. 2009
    ..Evaluate the impact of medical and surgical interventions on the survival of patients with papillary microcarcinoma (PMC) of the thyroid, a common tumor with an increasing worldwide incidence...
  91. doi Spatial and sex differences in AIDS mortality in Chiang Rai, Thailand
    Annitra Jongsthapongpanth
    Department of Geography, State University of New York at Buffalo, Wilkeson Quad, Buffalo, NY 14261, USA
    Health Place 16:1084-93. 2010
    ..A total of 2432 male and 1864 female deaths (2000-2004) from AIDS in Chiang Rai are used to detect mortality clusters...
  92. doi The alteration of asymmetric dimetilarginine (ADMA) levels in cardiac and gastrocnemius muscles following radioactive iodine application in guinea pigs and the effect of L-carnitine on this alteration
    Selma Arzu Vardar
    Department of Physiology, Trakya University Faculty of Medicine, Edirne, Turkey
    Int J Radiat Biol 87:2-7. 2011
    ..asymmetric dimetilarginine (ADMA) and symmetric dimetilarginine (SDMA) were investigated in cardiac ventricle and gastrocnemius muscles of guinea pigs treated with radioactive iodine (RAI) alone or in combination with L-carnitine (LC).
  93. doi A specific diplotype defined by PPP1R13L rs1970764, CD3EAP rs967591 and ERCC1 rs11615 and lung cancer risk in a Chinese population
    Jiaoyang Yin
    Key Laboratory of Environment and Population Health of Liaoning Education Ministry Shenyang Medical College, Shenyang 110034, Liaoning Province, People s Republic of China
    Lung Cancer 76:286-91. 2012
    ..370 cases and 388 controls was conducted to evaluate the effects of the high-risk diplotype predefined as PPP1R13L rs1970764(AA)-CD3EAP rs967591(GG)-ERCC1 rs11615(AA) among Caucasians and three SNPs alone or other haplotypes ..
  94. doi Management of thyroid carcinoma in children and young adults
    Louis Rapkin
    Aflac Cancer Center and Blood Disorders Service, Emory University School of Medicine, Atlanta, GA 30342, USA
    J Pediatr Hematol Oncol 34:S39-46. 2012
    ..Surgery remains the primary method of curing these patients, although radioactive iodine (RAI) may offer some benefit in WDTC for selected patients...
  95. doi Treating the thyroid in the presence of Graves' ophthalmopathy
    Laszlo Hegedus
    University of Southern Denmark, Odense, Denmark
    Best Pract Res Clin Endocrinol Metab 26:313-24. 2012
    ..Whether antithyroid drugs (ATDs), radioiodine (RAI), or thyroidectomy should be favored in such patients remains debated...
  96. doi Undetectable thyroglobulin after total thyroidectomy in patients with low- and intermediate-risk papillary thyroid cancer--is there a need for radioactive iodine therapy?
    Tihana Ibrahimpasić
    Head and Neck Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Surgery 152:1096-105. 2012
    The efficacy of radioactive iodine therapy (RAI) in patients who have an undetectable thyroglobulin (Tg) level after total thyroidectomy in well-differentiated papillary thyroid cancer (PTC) is questionable...
  97. doi Clinical, safety, and economic evidence in radioactive iodine-refractory differentiated thyroid cancer: a systematic literature review
    Roger T Anderson
    Department of Public Health Sciences, Penn State College of Medicine, Pennsylvania State University, Hershey, Pennsylvania, USA
    Thyroid 23:392-407. 2013
    ..While most cases of DTC are curable with the use of surgery and radioactive iodine (RAI) ablation of the remaining thyroid remnant, prognosis is dire and treatment options limited when DTC becomes RAI-..
  98. doi A promoter polymorphism in human interleukin-32 modulates its expression and influences the risk and the outcome of epithelial cell-derived thyroid carcinoma
    Theo S Plantinga
    Department of Medicine, Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, Nijmegen, 6525 GA, The Netherlands
    Carcinogenesis 34:1529-35. 2013
    ..71 (1.06-2.75). In addition, the cumulative radioactive iodine (RAI) dose received after total thyroidectomy was significantly higher in TC patients bearing the ancient T allele...
  99. doi Immediate, non-submerged, root-analogue direct laser metal sintering (DLMS) implants: a 1-year prospective study on 15 patients
    Francesco Guido Mangano
    Department of Surgical and Morphological Science, Dental School, University of Varese, Varese, Italy
    Lasers Med Sci 29:1321-8. 2014
    ..7 mm (±0.2). The possibility of fabricating custom-made, RAI DLMS implants opens new interesting horizons for immediate placement of dental implants.
  100. doi Should patients with remnants from thyroid microcarcinoma really not be treated with iodine-131 ablation?
    Rosj Gallicchio
    Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, Centro di Riferimento Oncologico di Basilicata CROB, Via P Pio 1, 85028, Rionero in Vulture, Italy
    Endocrine 44:426-33. 2013
    ..We retrospectively studied low-risk patients (pts) with differentiated thyroid cancer (DTC) less than 1 cm recruited for radioiodine therapy (RAI).
  101. doi Effects of PPP1R13L and CD3EAP variants on lung cancer susceptibility among nonsmoking Chinese women
    Jiaoyang Yin
    Key Laboratory of Environment and Population Health of Liaoning Education Ministry Shenyang Medical College, Shenyang 110034, Liaoning Province, People s Republic of China
    Gene 524:228-31. 2013
    The pathogenesis of lung cancer in the never-smokers could possibly be different from the one in smokers. PPP1R13L and CD3EAP on chromosome 19q13.3 are mainly involved in apoptosis and transcription...

Research Grants48

  1. Topical Microbicide Acceptability
    Alex Carballo Dieguez; Fiscal Year: 2006
    ..Focusing on HIV-negative men who have receptive anal intercourse (RAI) using condoms inconsistently or not at all, the primary aims of this study are to (1) determine, through a rectal ..
  2. ASISH KUMAR GHOSH; Fiscal Year: 2016
    ..that CLL B-cells can spontaneously or with stimulation produce LD MV in vitro irrespective of disease stages (Rai stage)...
  3. An Evaluation of Vaccination Practices of Nursing Home Residents and Staff
    David H Howard; Fiscal Year: 2011
    ..is to assess the validity of reported influenza vaccination status and race on the resident assessment instrument (RAI) by comparing RAI data to patient vaccination and medical records...
  4. Towards Measures of Lupus Nephritis Activity &Damage for Children
    Hermine I Brunner; Fiscal Year: 2012
    ..Aim #1b: To develop and initially validate for Children a Renal Activity Index (C-RAI) to non-invasively monitor LN activity...
  5. HEALTH, QUALITY OF CARE AND NURSING HOME CHOICE
    Andrew Foster; Fiscal Year: 1999
    ..Information on residents and new entrants is contained in the Resident Assessment Instrument (RAI) and Minimum Data Set (MDS)...
  6. Cyclic nucleotide phosphodiesterases isoforms as novel biomarkers in CLL
    Lingzhi Zhang; Fiscal Year: 2010
    ..Currently, clinical staging by the Rai and Binet criteria remains the foundation for determining prognosis and indication for treatment...
  7. A noninvasive optical imaging of retinal amyloid beta deposits in AD patients
    Maya Koronyo-Hamaoui; Fiscal Year: 2013
    ..perform an initial clinical imaging study and use the data to automate the calculation of a Retinal Amyloid Index (RAI), a quantitative measure of amyloid in the retina...
  8. BEHAVIORAL RESEARCH FOR AIDS PREVENTION IN THAILAND
    Maria Wawer; Fiscal Year: 1993
    ..The project, to be conducted in Bangkok in central Thailand, Chiang Rai in the north, and Hadyai in the south, will collect quantitative and qualitative behavioral data in brothels (..
  9. James A Fagin; Fiscal Year: 2014
    ..with BRAF mutation have lower expression of NIS, which likely explains why BRAF mutant PTCs are often resistant to RAI therapy...
  10. Family-to-Family: Psychoeducation to Improve Children's Outcomes in HIV+ Families
    Li Li; Fiscal Year: 2009
    ..In Phase 2, families with HIV+ parents (400 HIV+ parents, 600 family caregivers) from 4 district hospitals in Chang Rai &Nakhon Ratchasima Provinces will be recruited to an intervention to benefit their 960 school-aged children ..
  11. Genetic Models of Anterior Segment Development
    D J Sidjanin; Fiscal Year: 2012
    ..The woe mice carry a hypomorphic mutation in the Adam17 gene whereas the woe2 mice carry a deletion in the Ppp1r13l gene. The goal of this proposal is to understand the role of Adam17 and Ppp1r13l during the eye development...
  12. The Role of Oxidative Stress in CLL B-cell Apoptosis
    Tait D Shanafelt; Fiscal Year: 2010
    ..Conduct a clinical trial evaluating the efficacy of one ROS generating agent, EGCG, for treatment of patients with Rai state 0-II CLL...
  13. Rasa Zarnegar; Fiscal Year: 2016
    ....
  14. RAI CONDOM: Feasibility & Acceptability Study, Phase 1 Pilot Clinical Research
    DANIEL RESNIC; Fiscal Year: 2010
    ..by applicant): The purpose of this project is to research, refine and test three prototypes of the ORIGAMI RAI CONDOM, an RAI (receptive anal intercourse) condom made of a biocompatible, viral-impermeable silicone, which may ..
  15. Item Banking Across the Continuum of Care
    Craig A Velozo; Fiscal Year: 2013
    ..facilities (IRFs), and results obtained from the Minimum Data Set (MDS) of the Resident Assessment Instrument (RAI), which is collected to monitor functional status in VA Community Living Centers (CLC)...
  16. Megan Rist Haymart; Fiscal Year: 2015
    ..for well-differentiated thyroid cancer (WDTC) includes thyroid surgery often followed by radioactive iodine (RAI) and suppressive doses of thyroid hormone replacement...
  17. QUALITY IMPROVEMENT IN NURSING HOMES
    Francois Sainfort; Fiscal Year: 1999
    ..and (2) gathering routinely collected resident- level information using the Resident Assessment Instrument (RAI). These data will be collected simultaneously in two different years to study changes over a period of one year...
  18. New Proteins Binding Apoptotic Stimulator of p53, ASPP2
    LARRY ROHDE; Fiscal Year: 2004
    ..An ASPP family member, iASPP, acts as an oncoprotein that inhibits p53 activity...
  19. Angiogenesis in B Chronic Lymphocytic Leukemia
    Neil Kay; Fiscal Year: 2002
    ..This latter finding would strongly suggest that maneuvers to alter the angiogenic potential in B-CLL patients would be an important and novel therapeutic approach in this disease. ..
  20. B CLL Subtypes--Correlation with Clinical Outcome
    Neil Kay; Fiscal Year: 2002
    ....
  21. VEGF Function in B-CLL
    Neil E Kay; Fiscal Year: 2010
    ..3) Does the VEGF/VEGF-R pathway(s) found in CLL B cells correlate with either clinical and/or critical biologic parameters in B-CLL? ..
  22. Internet Use and HIV Risk among Men in NYC
    Alex Carballo Dieguez; Fiscal Year: 2005
    ..abstract_text> ..
  23. Predictors of HIV Risk Behavior Among Men in Argentina
    Alex Carballo Dieguez; Fiscal Year: 2009
    ..This is a fundamental step prior to designing programs that mitigate those factors and result in decreased risk. ..
  24. Inducible NOS as a Treatment Target in CLL
    J Weinberg; Fiscal Year: 2005
    ....
  25. MOLECULAR AND BIOLOGICAL FUNCTION OF CD40 IN MYELOMA
    Diane Jelinek; Fiscal Year: 2002
    ....
  26. CLONOTYPIC PCR FOR MINIMAL RESIDUAL DISEASE IN LYMPHOMA
    Ariela Noy; Fiscal Year: 2002
    ..In addition, the extensive patient population facilitates the execution of a large number of clinical protocols in a timely manner. ..
  27. DEVELOPING CIRCADIAN RHYTHMICITY
    Scott Rivkees; Fiscal Year: 2002
    ..These studies may also lead to the development of new care practices in Neonatal Intensive Care Units and extend the field of developmental chronobiology to the bedside. ..
  28. ENDOTHELIN IN HUMANS CORONARY IN EARLY ATHEROSCLEROSIS
    Amir Lerman; Fiscal Year: 2003
    ....
  29. Adenosinergic Mechanisms of Intrauterine Growth Retardation
    Scott A Rivkees; Fiscal Year: 2010
    ..The goals of this proposal are to identify the mechanisms by which adenosine acts to protect the embryo in utero and how altered embryonic adenosine action leads to long-term adverse effects in adulthood. ..
  30. A1-ADENOSINE RECEPTOR ACTION IN HIPPOCAMPUS
    Scott Rivkees; Fiscal Year: 2003
    ..We anticipate these studies will lead to new insights into the mechanisms of A1AR action. We also anticipate that these studies will identify A1ARs as an important regulator of axon growth. ..
  31. Vaccine therapy of congenital adrenal Hyperplasia
    Scott Rivkees; Fiscal Year: 2003
    ..We also anticipate being able to extend this novel approach to the treatment of other receptor-mediated endocrine disorders, such as hyperthyroidism. ..
  32. The Role of Adenosine in Hypoglycemic Brain Injury
    Scott Rivkees; Fiscal Year: 2003
    ..We anticipate that these studies will yield new insights into the mechanisms of hypoglycemic brain injury and may lead to the development of practical strategies for reducing hypoglycemic brain injury. ..
  33. PATHOGENESIS AND THERAPY OF AUTOIMMUNE THYROID DISEASE
    LESLIE DE GROOT; Fiscal Year: 2007
    ..R .G. Phelps, who will analyze TSH-R epitopes which we elute from DR3 molecules, Dr. W. Kwok, who will provide DR3 tetramers, and with Dr. M. Ludgate on the model of Graves' disease. ..
  34. Advanced Haplotype Analyses in Coronary Artery Disease
    Andrew Allen; Fiscal Year: 2008
    ..Allen's development into an established independent quantitative research scientist with expertise in both methodology for dissecting genetic factors in complex disease and cardiovascular genetics. ..
  35. role of BLyS/April in Normal and Malignant Plasma Cells
    Diane Jelinek; Fiscal Year: 2008
    ..abstract_text> ..
  36. MINORITY BASED COMMUNITY CLINICAL ONCOLOGY PROGRAM
    Peter Wiernik; Fiscal Year: 2006
    ..Efforts in screening and prevention intervention will be facilitated through the Community Outreach program and Community Council. ..
  37. Brca1 Deletion in Murine Cells and Mammary Tissue
    MARCIA BROSE; Fiscal Year: 2007
    ..abstract_text> ..
  38. Anti-Adenosine Therapy of Neonatal Brain Injury
    Scott Rivkees; Fiscal Year: 2007
    ..It is anticipated that these studies will lead to novel and practical strategies for directly preventing brain injury. [unreadable] [unreadable]..
  39. Coronary Endothelial Function in Humans
    Amir Lerman; Fiscal Year: 2006
    ..The success of this program has the potential to further both the research and mentoring endeavors of patient-oriented investigation and mentoring the next generation of patient-oriented researchers. ..
  40. CB1 Receptor Action on the Developing Hippocampus
    Scott Rivkees; Fiscal Year: 2005
    ..We anticipate that these studies will result in new insights into the potential effects of cannabinoid action on the developing brain. ..
  41. A-1 Adenosine Receptor Action in Developing Heart
    Scott Rivkees; Fiscal Year: 2005
    ..We anticipate that these studies will identify Rho and ROCK as critical signaling molecules in heart development and reveal that cardiac GTPase activity transduces the effects of adenosine. ..
  42. Developing Prevalence Measures of Elder Abuse in Residential Long-Term Care Setti
    MARY HAWES; Fiscal Year: 2008
    ..Thus, the study addresses the CDC's Healthy People 2010 goals of assuring "Access to Quality Health Services--Long-term Care" and of "Injury and Violence Prevention." [unreadable] [unreadable] [unreadable]..
  43. DEPSIPEPTIDE: A NOVEL HISTONE DEACYTLASE INHIBITOR IN L
    John Byrd; Fiscal Year: 2003
    ..The clinical and laboratory results of this trial will provide pharmacokinetic and pharmacodynamic information for additional correlative efforts in both single agent phase II and combination phase I studies. ..
  44. Anal Dysplasia in HIV+ and HIV- men
    Timothy Wilkin; Fiscal Year: 2006
    ..This study will help provide important new information on which groups of HIV+ men may benefit from screening and how HAART may modify this risk. ..
  45. A PHASE 1 Study of HuD10 IN CLL/SLL PATIENTS
    John Byrd; Fiscal Year: 2002
    ..These laboratory studies combined with clinical data derived from this trial will form the basis for future phase II development of this agent in CLL/SLL. ..
  46. Epigenetic Targeted Therapy for Chronic Lymphocytic Leu*
    John Byrd; Fiscal Year: 2005
    ..abstract_text> ..
  47. Molecular Markers: Response to Chemo-immunotherapy in C*
    John Byrd; Fiscal Year: 2005
    ..Such therapy would potentially administer different types of chemoimmunotherapy based upon the presence or absence of IgVH mutational status and p53 dysfunction. ..
  48. QUALITY MEASUREMENT IN RESIDENTIAL CARE
    MARY HAWES; Fiscal Year: 2001
    ..In short, we propose a multi-faceted approach to developing and using quality measures to improve health care services to the vulnerable populations residing in RCFs. ..