PPFIA2

Summary

Gene Symbol: PPFIA2
Description: PTPRF interacting protein alpha 2
Alias: liprin-alpha-2, protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
Species: human

Top Publications

  1. ncbi Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting
    Michael Wyszynski
    Department of Neurobiology and Howard Hughes Medical Institute, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Neuron 34:39-52. 2002
  2. ncbi Genome-wide association study of multiplex schizophrenia pedigrees
    Douglas F Levinson
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif, USA
    Am J Psychiatry 169:963-73. 2012
  3. pmc Novel HIV-1 knockdown targets identified by an enriched kinases/phosphatases shRNA library using a long-term iterative screen in Jurkat T-cells
    Sylvie Rato
    URIA Centro de Patogénese Molecular, Faculdade de Farmacia, Universidade de Lisboa, Lisboa, Portugal
    PLoS ONE 5:e9276. 2010
  4. pmc Electronic medical records and genomics (eMERGE) network exploration in cataract: several new potential susceptibility loci
    Marylyn D Ritchie
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA
    Mol Vis 20:1281-95. 2014
  5. doi SNP array screening of cryptic genomic imbalances in 450 Japanese subjects with intellectual disability and multiple congenital anomalies previously negative for large rearrangements
    Daniela Tiaki Uehara
    Department of Molecular Cytogenetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    J Hum Genet 61:335-43. 2016
  6. pmc Association mapping of the high-grade myopia MYP3 locus reveals novel candidates UHRF1BP1L, PTPRR, and PPFIA2
    Felicia Hawthorne
    Duke Center for Human Genetics, Duke University, Durham, NC 27710, USA
    Invest Ophthalmol Vis Sci 54:2076-86. 2013
  7. ncbi Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins
    C Serra-Pages
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Biol Chem 273:15611-20. 1998
  8. ncbi Liprin-alpha2 gene, protein tyrosine phosphatase LAR interacting protein related gene, is downregulated by androgens in the human prostate cancer cell line LNCaP
    Kiyoshi Fujinami
    Department of Urology, Yokohama City University, Yokohama, Japan
    Int J Mol Med 10:173-6. 2002
  9. ncbi Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting
    Jaewon Ko
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    J Neurosci 23:1667-77. 2003
  10. ncbi Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins
    Jaewon Ko
    National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    J Biol Chem 278:42377-85. 2003

Research Grants

  1. GENETIC LINKAGE OF SCHIZOPHRENIA AND RELATED STUDIES
    Douglas Levinson; Fiscal Year: 2005
  2. MOLECULAR GENETICS OF SCHIZOPHRENIA
    Douglas Levinson; Fiscal Year: 2007
  3. Genetics of Early-Onset Depression
    Douglas Levinson; Fiscal Year: 2008
  4. Multicenter Genetics Studies of Schizophrenia
    Douglas Levinson; Fiscal Year: 2008

Scientific Experts

  • DOUGLAS FREDERICK LEVINSON
  • Jaewon Ko
  • Daniela Tiaki Uehara
  • Marylyn D Ritchie
  • Felicia Hawthorne
  • Zhiyi Wei
  • Sylvie Rato
  • Eunjoon Kim
  • Hiroshi Mitsubuchi
  • Jae Ran Lee
  • Kenji Kurosawa
  • Nobuhiko Okamoto
  • Seiji Mizuno
  • Akira Hata
  • Masuko Katoh
  • Yoshio Makita
  • Shinji Saitoh
  • Shin Hayashi
  • Hironao Numabe
  • Johji Inazawa
  • Hiroshi Matsumoto
  • Rika Kosaki
  • Seho Kim
  • Yasutsugu Chinen
  • Issei Imoto
  • Tomoki Kosho
  • Richard J Weinberg
  • Morgan Sheng
  • Juli G Valtschanoff
  • Rongling Li
  • Joshua C Denny
  • Lin Chen
  • Catherine A McCarty
  • James G Linneman
  • Robert J Goodloe
  • Russell A Wilke
  • Stephen D Turner
  • Molly A Hall
  • Richard L Berg
  • Andrea H Ramirez
  • Luke V Rasmussen
  • Jyoti Pathak
  • Kiyoshi Fujinami
  • Eric S Torstenson
  • David R Crosslin
  • Christopher S Carlson
  • Xiaoming Wang
  • Shefali S Verma
  • Wendy A Wolf
  • Peggy Peissig
  • Michael Wyszynski
  • Dave S Carrell
  • GAIL JARVIK
  • David A Mackey
  • Jeremy A Guggenheim
  • Cristina Venturini
  • Pirro G Hysi
  • Francois Malecaze
  • Patrick Calvas
  • Sheng Feng
  • Yi Ju Li
  • Thomas Rosenberg
  • Christopher J Hammond
  • Ravikanth Metlapally
  • Terri L Young
  • Khanh Nhat Tran-Viet
  • Cong Yu
  • Mingjie Zhang
  • Samantha A Spangler
  • Casper C Hoogenraad
  • Suilan Zheng
  • Carina F Pereira
  • Luis Ferreira Moita
  • Jose Moniz-Pereira
  • Sara Maia
  • Paula M Brito
  • Nir Hacohen
  • Rui P Freitas
  • Joao Goncalves
  • Catarina Moita
  • Leonor Resende
  • C Serra-Pages
  • Hyewon Shin
  • Masaru Katoh
  • Moonseok Na
  • Richard T Premont
  • Maria Passafaro
  • Michel Streuli
  • Hiroji Uemura
  • Yoshinobu Kubota

Detail Information

Publications12

  1. ncbi Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting
    Michael Wyszynski
    Department of Neurobiology and Howard Hughes Medical Institute, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Neuron 34:39-52. 2002
    ..Thus, by mediating the targeting of liprin/GRIP-associated proteins, liprin-alpha is important for postsynaptic as well as presynaptic maturation...
  2. ncbi Genome-wide association study of multiplex schizophrenia pedigrees
    Douglas F Levinson
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif, USA
    Am J Psychiatry 169:963-73. 2012
    ..The authors used a genome-wide association study (GWAS) of multiply affected families to investigate the association of schizophrenia to common single-nucleotide polymorphisms (SNPs) and rare copy number variants (CNVs)...
  3. pmc Novel HIV-1 knockdown targets identified by an enriched kinases/phosphatases shRNA library using a long-term iterative screen in Jurkat T-cells
    Sylvie Rato
    URIA Centro de Patogénese Molecular, Faculdade de Farmacia, Universidade de Lisboa, Lisboa, Portugal
    PLoS ONE 5:e9276. 2010
    ..This study brings new insights for the complex interplay of HIV-1/host cell and opens new possibilities for antiviral strategies...
  4. pmc Electronic medical records and genomics (eMERGE) network exploration in cataract: several new potential susceptibility loci
    Marylyn D Ritchie
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA
    Mol Vis 20:1281-95. 2014
    ..The purpose of this study was to identify genetic markers for age-related cataract through a genome-wide association study (GWAS)...
  5. doi SNP array screening of cryptic genomic imbalances in 450 Japanese subjects with intellectual disability and multiple congenital anomalies previously negative for large rearrangements
    Daniela Tiaki Uehara
    Department of Molecular Cytogenetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    J Hum Genet 61:335-43. 2016
    ..Among the 22 cases, we identified PPFIA2 as a novel candidate gene for ID...
  6. pmc Association mapping of the high-grade myopia MYP3 locus reveals novel candidates UHRF1BP1L, PTPRR, and PPFIA2
    Felicia Hawthorne
    Duke Center for Human Genetics, Duke University, Durham, NC 27710, USA
    Invest Ophthalmol Vis Sci 54:2076-86. 2013
    ..Myopia, or nearsightedness, is a common ocular genetic disease for which over 20 candidate genomic loci have been identified. The high-grade myopia locus, MYP3, has been reported on chromosome 12q21-23 by four independent linkage studies...
  7. ncbi Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins
    C Serra-Pages
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Biol Chem 273:15611-20. 1998
    ..We propose that liprins function to localize LAR family tyrosine phosphatases at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates...
  8. ncbi Liprin-alpha2 gene, protein tyrosine phosphatase LAR interacting protein related gene, is downregulated by androgens in the human prostate cancer cell line LNCaP
    Kiyoshi Fujinami
    Department of Urology, Yokohama City University, Yokohama, Japan
    Int J Mol Med 10:173-6. 2002
    ....
  9. ncbi Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting
    Jaewon Ko
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    J Neurosci 23:1667-77. 2003
    ..These results suggest that the GIT1-liprin-alpha interaction is required for AMPA receptor targeting and that GIT1 may play an important role in the organization of presynaptic and postsynaptic multiprotein complexes...
  10. ncbi Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins
    Jaewon Ko
    National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    J Biol Chem 278:42377-85. 2003
    ..These results suggest that the interaction between ERC2 and liprin-alpha may be involved in the presynaptic localization of liprin-alpha and the molecular organization of presynaptic active zones...
  11. ncbi Identification and characterization of human PPFIA4 gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 12:1009-14. 2003
    ..3, while exons 11-29 within AL451082.6. PPFIA4-MYOG locus (human chromosome 1q32.1) was paralogous to PPFIA2-LIN7A-MYF5-MYF6 locus (12q21.31), which was also paralogous to PPFIA3-LIN7B locus (19q13.41)...
  12. doi Liprin-mediated large signaling complex organization revealed by the liprin-α/CASK and liprin-α/liprin-β complex structures
    Zhiyi Wei
    Division of Life Science, State Key Laboratory of Molecular Neuroscience, Molecular Neuroscience Center, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
    Mol Cell 43:586-98. 2011
    ..Finally, formation of the CASK/liprin-α/liprin-β ternary complex suggests that liprins can mediate assembly of target proteins into large protein complexes capable of regulating numerous cellular activities...

Research Grants4

  1. GENETIC LINKAGE OF SCHIZOPHRENIA AND RELATED STUDIES
    Douglas Levinson; Fiscal Year: 2005
    ..abstract_text> ..
  2. MOLECULAR GENETICS OF SCHIZOPHRENIA
    Douglas Levinson; Fiscal Year: 2007
    ..The goal of the study is to identify one or more SZ susceptibility genes whose subsequent characterization inmolecular and functional studies will elucidate the pathophysiology and treatment of SZ. ..
  3. Genetics of Early-Onset Depression
    Douglas Levinson; Fiscal Year: 2008
    ..abstract_text> ..
  4. Multicenter Genetics Studies of Schizophrenia
    Douglas Levinson; Fiscal Year: 2008
    ..unreadable] [unreadable]..