PPARGC1A

Summary

Gene Symbol: PPARGC1A
Description: PPARG coactivator 1 alpha
Alias: LEM6, PGC-1(alpha), PGC-1alpha, PGC-1v, PGC1, PGC1A, PPARGC1, peroxisome proliferator-activated receptor gamma coactivator 1-alpha, L-PGC-1alpha, PGC-1-alpha, PPAR gamma coactivator variant form, PPARGC-1-alpha, PPARgamma coactivator 1alpha, ligand effect modulator-6, peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-3ext, peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-8a, peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5-NT
Species: human

Top Publications

  1. ncbi Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres
    Jiandie Lin
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 418:797-801. 2002
  2. ncbi Peroxisome proliferator-activated receptor gamma coactivator 1 alpha promoter polymorphisms are associated with early-onset type 2 diabetes mellitus in the Korean population
    J H Kim
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, 110 744, South Korea
    Diabetologia 48:1323-30. 2005
  3. ncbi A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
    P Puigserver
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 92:829-39. 1998
  4. doi Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1alpha in human skeletal muscle
    Martin J Gibala
    Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada
    J Appl Physiol (1985) 106:929-34. 2009
  5. ncbi The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (ERRalpha)
    Sylvia N Schreiber
    Division of Biochemistry, Biozentrum of the University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    J Biol Chem 278:9013-8. 2003
  6. ncbi Analysis of PGC-1alpha variants Gly482Ser and Thr612Met concerning their PPARgamma2-coactivation function
    Inke Nitz
    Molecular Nutrition, Christian Albrechts University of Kiel, Kiel, Germany
    Biochem Biophys Res Commun 353:481-6. 2007
  7. pmc PGC1α promotes tumor growth by inducing gene expression programs supporting lipogenesis
    Kavita Bhalla
    Department of Biochemistry and Molecular Biology, University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, Maryland, USA
    Cancer Res 71:6888-98. 2011
  8. pmc DNA sequence variants in PPARGC1A, a gene encoding a coactivator of the ω-3 LCPUFA sensing PPAR-RXR transcription complex, are associated with NV AMD and AMD-associated loci in genes of complement and VEGF signaling pathways
    John Paul SanGiovanni
    Clinical Trials Branch, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 8:e53155. 2013
  9. doi PGC-1α is a male-specific disease modifier of human and experimental amyotrophic lateral sclerosis
    Judith Eschbach
    Neurology, Ulm University, 89081 Ulm, Germany
    Hum Mol Genet 22:3477-84. 2013
  10. ncbi PGC-1alpha: a key regulator of energy metabolism
    Huiyun Liang
    Department of Cellular and Structural Biology, Audie Murphy Veterans Administration Medical Center and University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Adv Physiol Educ 30:145-51. 2006

Research Grants

  1. Activity Dependent Signaling in Adult Skeletal Muscle Fiber Plasticity
    Martin F Schneider; Fiscal Year: 2012
  2. Min You; Fiscal Year: 2016
  3. Regulation and Function of the Rhox5 Homeobox Gene
    MILES FROME WILKINSON; Fiscal Year: 2013
  4. Bruce M Spiegelman; Fiscal Year: 2016
  5. S Russ Price; Fiscal Year: 2015
  6. Pere Puigserver; Fiscal Year: 2016
  7. Regulation of Skeletal Muscle Angiogenesis by PGC-1 alpha
    Srilatha Raghuram; Fiscal Year: 2012
  8. Satyanarayana Ande; Fiscal Year: 2015
  9. Hei Sook Sul; Fiscal Year: 2016
  10. Rev-ERBa Regulates Mitochondrial Biogenesis, Adiposity, and Insulin Action
    Thomas H Reynolds; Fiscal Year: 2010

Detail Information

Publications227 found, 100 shown here

  1. ncbi Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres
    Jiandie Lin
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 418:797-801. 2002
    ..These data indicate that PGC-1 alpha is a principal factor regulating muscle fibre type determination...
  2. ncbi Peroxisome proliferator-activated receptor gamma coactivator 1 alpha promoter polymorphisms are associated with early-onset type 2 diabetes mellitus in the Korean population
    J H Kim
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, 110 744, South Korea
    Diabetologia 48:1323-30. 2005
    ..Therefore, genetic variation of PPARGC1A could be implicated in the onset of type 2 diabetes...
  3. ncbi A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
    P Puigserver
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 92:829-39. 1998
    ..These results indicate that PGC-1 plays a key role in linking nuclear receptors to the transcriptional program of adaptive thermogenesis...
  4. doi Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1alpha in human skeletal muscle
    Martin J Gibala
    Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada
    J Appl Physiol (1985) 106:929-34. 2009
    ....
  5. ncbi The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (ERRalpha)
    Sylvia N Schreiber
    Division of Biochemistry, Biozentrum of the University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    J Biol Chem 278:9013-8. 2003
    ....
  6. ncbi Analysis of PGC-1alpha variants Gly482Ser and Thr612Met concerning their PPARgamma2-coactivation function
    Inke Nitz
    Molecular Nutrition, Christian Albrechts University of Kiel, Kiel, Germany
    Biochem Biophys Res Commun 353:481-6. 2007
    ..This is the first study implicating that the Gly482Ser and Thr612Met polymorphisms in PGC-1alpha and Pro12Ala polymorphism in PPARgamma2 do not affect the functional integrity of these proteins...
  7. pmc PGC1α promotes tumor growth by inducing gene expression programs supporting lipogenesis
    Kavita Bhalla
    Department of Biochemistry and Molecular Biology, University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, Maryland, USA
    Cancer Res 71:6888-98. 2011
    ..PPARγ coactivator 1α (PGC1α) is a key transcriptional regulator of several metabolic pathways including oxidative metabolism and lipogenesis...
  8. pmc DNA sequence variants in PPARGC1A, a gene encoding a coactivator of the ω-3 LCPUFA sensing PPAR-RXR transcription complex, are associated with NV AMD and AMD-associated loci in genes of complement and VEGF signaling pathways
    John Paul SanGiovanni
    Clinical Trials Branch, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 8:e53155. 2013
    ..We postulated that DNA sequence variation in PPAR gamma (PPARG) co-activator 1 alpha (PPARGC1A), a gene encoding a co-activator of the LCPUFA-sensing PPARG-retinoid X receptor (RXR) transcription complex, may ..
  9. doi PGC-1α is a male-specific disease modifier of human and experimental amyotrophic lateral sclerosis
    Judith Eschbach
    Neurology, Ulm University, 89081 Ulm, Germany
    Hum Mol Genet 22:3477-84. 2013
    ..In summary, we indentify PGC-1α as a novel and clinically relevant disease modifier of human and experimental ALS and report a sex-dependent effect of PGC-1α in this neurodegenerative disorder. ..
  10. ncbi PGC-1alpha: a key regulator of energy metabolism
    Huiyun Liang
    Department of Cellular and Structural Biology, Audie Murphy Veterans Administration Medical Center and University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Adv Physiol Educ 30:145-51. 2006
    ..In particular, its regulatory function in lipid metabolism makes it an inviting target for pharmacological intervention in the treatment of obesity and Type 2 diabetes...
  11. ncbi PGC-1alpha: a potent transcriptional cofactor involved in the pathogenesis of type 2 diabetes
    S Soyal
    Department of Internal Medicine, Krankenhaus Hallein, 5400, Hallein, Austria
    Diabetologia 49:1477-88. 2006
    ....
  12. doi Matched work high-intensity interval and continuous running induce similar increases in PGC-1α mRNA, AMPK, p38, and p53 phosphorylation in human skeletal muscle
    Jonathan D Bartlett
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom
    J Appl Physiol (1985) 112:1135-43. 2012
    ..Furthermore, this is the first report of contraction-induced p53 phosphorylation in human skeletal muscle, thus highlighting an additional pathway by which exercise may initiate mitochondrial biogenesis...
  13. ncbi A novel heterozygous mutation in peroxisome proliferator-activated receptor-gamma gene in a patient with familial partial lipodystrophy
    Anil K Agarwal
    Department of Internal Medicine, Division of Nutrition and Metabolic Diseases and Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Clin Endocrinol Metab 87:408-11. 2002
    ..None of the four unaffected family members harbored the mutation. We conclude that heterozygous, R425C, mutation in PPARG could be the molecular basis for one of the familial partial lipodystrophy phenotypes...
  14. ncbi Peroxisome proliferator-activated receptors (PPARs) and associated transcription factors in colon cancer: reduced expression of PPARgamma-coactivator 1 (PGC-1)
    Jonas Feilchenfeldt
    Division of Endocrinology and Diabetes, Department of Medicine, University Hospital Geneva, 24 Rue Micheli du Crest, CH 1211 Geneva 14, Switzerland
    Cancer Lett 203:25-33. 2004
    ..Taken together our data suggest that the transcriptional activity of PPARgamma may not only be decreased by mutation but also by downregulation of the coactivator PGC-1 of PPARgamma...
  15. ncbi Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration
    Libin Cui
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, MassGeneral Institute for Neurodegeneration, Charlestown, MA 02129 USA
    Cell 127:59-69. 2006
    ..These studies suggest a key role for PGC-1alpha in the control of energy metabolism in the early stages of HD pathogenesis...
  16. pmc Distinct regulation of hepatitis B virus biosynthesis by peroxisome proliferator-activated receptor gamma coactivator 1alpha and small heterodimer partner in human hepatoma cell lines
    Caitlin R Ondracek
    Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Virol 83:12545-51. 2009
    ..Therefore, this approach indicates that the transcriptional regulation of HBV biosynthesis in HepG2 and Huh7 cells is primarily controlled by different transcription factors...
  17. ncbi Activation of PPARgamma coactivator-1 through transcription factor docking
    P Puigserver
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Science 286:1368-71. 1999
    ..Thus, transcription factor docking switches on the activity of a coactivator protein...
  18. pmc The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes
    R B Vega
    Center for Cardiovascular Research, Departments of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Cell Biol 20:1868-76. 2000
    ....
  19. ncbi CREB regulates hepatic gluconeogenesis through the coactivator PGC-1
    S Herzig
    Peptide Biology Laboratories, Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, California 92037 1002, USA
    Nature 413:179-83. 2001
    ..Fasting hyperglycaemia is strongly correlated with type II diabetes, so our results suggest that the activation of PGC-1 by CREB in liver contributes importantly to the pathogenesis of this disease...
  20. doi The biology of PGC-1α and its therapeutic potential
    Christoph Handschin
    Biozentrum, University of Basel, Klingelbergstrasse 50 70, CH 4056 Basel, Switzerland
    Trends Pharmacol Sci 30:322-9. 2009
    ..In addition, perspectives regarding the therapeutic importance of PGC-1alpha-controlled cellular and systemic metabolism are outlined...
  21. ncbi PGC-1alpha Gly482Ser polymorphism is associated with the plasma adiponectin level in type 2 diabetic men
    Yukiyoshi Okauchi
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Endocr J 55:991-7. 2008
    ..Therefore the observed gender-specific association between PGC-1alpha and the plasma adiponectin level may reflect linkage disequilibrium of Gly482Ser polymorphism with other causative variations...
  22. pmc Peroxisome proliferator-activated receptor gamma co-activator 1alpha (PGC-1alpha) and sirtuin 1 (SIRT1) reside in mitochondria: possible direct function in mitochondrial biogenesis
    Katia Aquilano
    Department of Biology, University of Rome Tor Vergata, 00133 Rome, Italy
    J Biol Chem 285:21590-9. 2010
    ..Finally, this work adds new knowledge on the function of SIRT1 and PGC-1alpha and highlights the direct involvement of such proteins in regulation of mitochondrial biogenesis...
  23. ncbi The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha
    Dieter Kressler
    Division of Biochemistry, Biozentrum of the University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    J Biol Chem 277:13918-25. 2002
    ..Finally, PERC enhances the ERalpha-mediated response to the partial agonist tamoxifen, while PGC-1 modestly represses it. The two coactivators are likely to mediate distinct, tissue-specific responses to estrogens...
  24. pmc Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator
    Sailesh Surapureddi
    Department of Pathology, Northwestern University, The Feinberg School of Medicine, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 99:11836-41. 2002
    ..The composition of this complex may provide insight into the basis of tissue and species sensitivity to peroxisome proliferators...
  25. pmc Potentiation of liver X receptor transcriptional activity by peroxisome-proliferator-activated receptor gamma co-activator 1 alpha
    Hannes Oberkofler
    Department of Laboratory Medicine, Landeskliniken Salzburg, A 5020 Salzburg, Austria
    Biochem J 371:89-96. 2003
    Peroxisome-proliferator-activated receptor (PPAR) gamma co-activator 1 alpha (PGC-1 alpha/PPARGC1) plays an important role in energy metabolism by co-ordinating transcriptional programmes of mitochondrial biogenesis, adaptive ..
  26. ncbi Gly482Ser polymorphism of the peroxisome proliferator-activated receptor-gamma coactivator-1 gene might be a risk factor for diabetic retinopathy in Slovene population (Caucasians) with type 2 diabetes and the Pro12Ala polymorphism of the PPARgamma gene i
    Mojca Globocnik Petrovic
    Eye Clinic, University Medical Centre Ljubljana, Slovenia
    Diabetes Metab Res Rev 21:470-4. 2005
    ..The PPARgamma gene and its coactivator, the peroxisome proliferator-activated receptor-gamma coactivator-1 (PPARGC1) gene, have been implicated to be involved in glucose uptake and altered lipid oxidation...
  27. doi Acute endurance exercise increases the nuclear abundance of PGC-1alpha in trained human skeletal muscle
    Jonathan P Little
    Department of Kinesiology, McMaster University, Ivor Wynne Centre, Hamilton, ON L8S 4K1
    Am J Physiol Regul Integr Comp Physiol 298:R912-7. 2010
    ....
  28. ncbi No association between the G482S polymorphism of the proliferator-activated receptor-gamma coactivator-1 (PGC-1) gene and Type II diabetes in French Caucasians
    C Lacquemant
    Diabetologia 45:602-3; author reply 604. 2002
  29. ncbi Single nucleotide polymorphisms of PPARD in combination with the Gly482Ser substitution of PGC-1A and the Pro12Ala substitution of PPARG2 predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial
    Laura Andrulionyte
    Department of Medicine, University of Kuopio, 70210 Kuopio, Finland
    Diabetes 55:2148-52. 2006
    ..We conclude that SNPs in PPARD modify the conversion from IGT to type 2 diabetes, particularly in combination with the SNPs of PGC-1A and PPARG2...
  30. pmc PPARGC1A coding variation may initiate impaired NEFA clearance during glucose challenge
    P W Franks
    Genetic Epidemiology and Clinical Research Group, Department of Public Health and Clinical Medicine, Section for Medicine, Umea University Hospital, Umea, Sweden
    Diabetologia 50:569-73. 2007
    The peroxisome proliferator-activated receptor gamma coactivator 1-alpha protein, encoded by the PPARGC1A gene, transcriptionally activates a complex pathway of lipid and glucose metabolism and is expressed primarily in tissues of high ..
  31. doi PPAR-alpha L162V and PGC-1 G482S gene polymorphisms, but not PPAR-gamma P12A, are associated with alcohol consumption in a Spanish Mediterranean population
    F Frances
    Department of Preventive and Legal Medicine, School of Medicine, University of Valencia, Valencia, Spain
    Clin Chim Acta 398:70-4. 2008
    ..However, no studies in humans exist. Our aim is to estimate the possible association between polymorphisms in the PPAR-alpha, PPAR-gamma and PPAR-gamma co-activator 1A (PGC-1A) genes and alcohol consumption in humans...
  32. pmc The PPARGC1A Gly482Ser polymorphism is associated with left ventricular diastolic dysfunction in men
    Erik Ingelsson
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    BMC Cardiovasc Disord 8:37. 2008
    The Gly482Ser polymorphism in peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PPARGC1A) has been demonstrated to be associated with diabetes, obesity and hypertension, all of which are important risk factors for left ..
  33. doi PPARGC1A sequence variation and cardiovascular risk-factor levels: a study of the main genetic effects and gene x environment interactions in children from the European Youth Heart Study
    E C Brito
    Genetic Epidemiology and Clinical Research Group, Department of Public Health and Clinical Medicine, Umea University Hospital, Medicine Clinic, Level 4, Stair B, Umea, 901 87, Sweden
    Diabetologia 52:609-13. 2009
    The PPARGC1A gene coactivates multiple nuclear transcription factors involved in cellular energy metabolism and vascular stasis...
  34. ncbi Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression
    H Esterbauer
    Department of Laboratory Medicine, Landeskliniken Salzburg, Salzburg, Austria
    Genomics 62:98-102. 1999
    ..1998, Cell 92, 829-839). We report here the characterization of the human PPARGC1 gene...
  35. pmc A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen
    D Knutti
    Division of Biochemistry, Biozentrum of the University of Basel, CH 4056 Basel, Switzerland
    Mol Cell Biol 20:2411-22. 2000
    ..One of the identified cDNAs, isolated in the screen as ligand effect modulator 6, showed no homology to yeast or Caenorhabditis elegans proteins but high similarity to the recently ..
  36. ncbi Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus
    J Ek
    Steno Diabetes Center and Hagedorn Research Institute, Niels Steensens Vej 2, DK 2820 Gentofte, Copenhagen, Denmark
    Diabetologia 44:2220-6. 2001
    ..This study aimed to investigate if variability in the peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) gene is associated with Type II (non-insulin-dependent) diabetes mellitus...
  37. ncbi Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and -gamma. Identification of novel leucine-rich interaction motif within PGC-1alpha
    Janice M Huss
    Department of Medicine, Center for Cardiovascular Research, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    J Biol Chem 277:40265-74. 2002
    ....
  38. ncbi Reduced expression of PGC-1 and insulin-signaling molecules in adipose tissue is associated with insulin resistance
    A Hammarstedt
    The Lundberg Laboratory for Diabetes Research, Department of Internal Medicine, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
    Biochem Biophys Res Commun 301:578-82. 2003
    ..The combined reduction of PGC-1 and insulin signaling molecules in adipose tissue implicates adipose tissue dysfunction which, in turn, can impair the systemic insulin response in the insulin-resistant subjects...
  39. ncbi Complex haplotypes of the PGC-1alpha gene are associated with carbohydrate metabolism and type 2 diabetes
    Hannes Oberkofler
    Department of Laboratory Medicine, Landeskliniken and Paracelsus Private Medical University Salzburg, Mullner Hauptstrasse 48, A 5020 Salzburg, Austria
    Diabetes 53:1385-93. 2004
    ..01). Thus, the PGC-1alpha gene locus influences carbohydrate metabolism and contributes to type 2 diabetes in the population studied...
  40. ncbi Common polymorphisms of the PPAR-gamma2 (Pro12Ala) and PGC-1alpha (Gly482Ser) genes are associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trial
    L Andrulionyte
    Department of Medicine, University of Kuopio, 70210, Kuopio, Finland
    Diabetologia 47:2176-84. 2004
    ..This trial aimed to study the effect of acarbose in the prevention of type 2 diabetes...
  41. ncbi The Gly482Ser polymorphism in the peroxisome proliferator-activated receptor-gamma coactivator-1 gene is associated with hypertension in type 2 diabetic men
    N Cheurfa
    INSERM Research Unit 561, Hopital Saint Vincent de Paul, 82 avenue Denfert Rochereau, 75014 Paris, France
    Diabetologia 47:1980-3. 2004
    Peroxisome proliferator-activated receptor-gamma coactivator-1 (PPARGC1) acts as a cofactor for several nuclear hormone receptors in many tissues and organs implicated in blood pressure regulation...
  42. ncbi Peroxisome proliferator-activated receptor-gamma coactivator-1alpha polymorphism is not associated with essential hypertension and type 2 diabetes mellitus in Chinese population
    Shufeng Chen
    Division of Population Genetics and Prevention, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
    Hypertens Res 27:813-20. 2004
    ..In conclusion, these results indicated that these two variations in the PGC-1alpha gene might not contribute to the risk of hypertension and type 2 diabetes in the Chinese population studied here...
  43. ncbi Haplotypes of PPARGC1A are associated with glucose tolerance, body mass index and insulin sensitivity in offspring of patients with type 2 diabetes
    J Pihlajamaki
    Department of Medicine, University of Kuopio, P O Box 1627, 70210, Kuopio, Finland
    Diabetologia 48:1331-4. 2005
    Decreased expression of the peroxisomal proliferator activated receptor gamma coactivator 1 alpha gene (PPARGC1A) is found in patients with type 2 diabetes, and variants in this gene have been linked with type 2 diabetes...
  44. ncbi Peroxisome proliferator-activated receptor gamma and its coactivator-1 alpha may be associated with features of the metabolic syndrome in adolescents
    S Sookoian
    Cardiologia Molecular, Instituto de Investigaciones Medicas A Lanari, Universidad de Buenos Aires, Buenos Aires, Argentina
    J Mol Endocrinol 35:373-80. 2005
    ..In conclusion, the Gly482 Ser variant of the PGC-1alpha gene may be an independent genetic risk factor for young-onset hypertension...
  45. ncbi Meta-analysis of the Gly482Ser variant in PPARGC1A in type 2 diabetes and related phenotypes
    I Barroso
    The Wellcome Trust Sanger Institute, Metabolic Disease Group, The Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
    Diabetologia 49:501-5. 2006
    Peroxisome proliferator-activated receptor-gamma co-activator-1alpha (PPARGC1A) is a transcriptional co-activator with a central role in energy expenditure and glucose metabolism...
  46. ncbi Increased risk of obesity associated with the variant allele of the PPARGC1A Gly482Ser polymorphism in physically inactive elderly men
    M Ridderstrale
    Department of Clinical Sciences Clinical Obesity, Malmo University Hospital, Lund University, S 205 02 Malmo, Sweden
    Diabetologia 49:496-500. 2006
    ..allele of the Gly482Ser polymorphism in peroxisome proliferator-activated receptor-gamma co-activator-1alpha (PPARGC1A or PGC1alpha), a critical determinant of skeletal muscle metabolism, has been associated with obesity and type 2 ..
  47. ncbi Identification of a candidate genetic variant for the high prevalence of type II diabetes in Polynesians
    Sean Myles
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Eur J Hum Genet 15:584-9. 2007
    ..The susceptibility allele in the PPARGC1A gene is at a frequency of 0.717 in Polynesians, 0.368 in Chinese but is absent in the New Guineans...
  48. ncbi Association between peroxisome proliferator-activated receptor-gamma coactivator-1alpha gene polymorphisms and type 2 diabetes in southern Chinese population: role of altered interaction with myocyte enhancer factor 2C
    Shao Ling Zhang
    Department of Endocrinology, Second Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    Chin Med J (Engl) 120:1878-85. 2007
    ....
  49. ncbi [Association study between PPARGC1A Thr394Thr/ Gly482Ser polymorphisms and type 2 diabetes]
    Yan Su
    College of Life Sciences, Central China Normal University, Wuhan 430079, China
    Yi Chuan 30:304-8. 2008
    ..rs2970847(Thr394Thr) and rs8192678(Gly482Ser) of peroxisome proliferators activated receptor gamma coactivator-1(PPARGC1A)gene and type 2 diabetes in Chinese Han population in Hubei...
  50. ncbi Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1
    Z Wu
    Dana Farber Cancer Institute, and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 98:115-24. 1999
    ..These data elucidate a pathway that directly links external physiological stimuli to the regulation of mitochondrial biogenesis and function...
  51. ncbi Modulation of estrogen receptor-alpha transcriptional activity by the coactivator PGC-1
    I Tcherepanova
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 275:16302-8. 2000
    ..It is concluded from these studies that PGC-1 is a bona fide ERalpha coactivator, which may serve as a convergence point between PPARgamma and ERalpha signaling...
  52. ncbi PGC-1, a versatile coactivator
    D Knutti
    Division of Biochemistry, Biozentrum of the University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Trends Endocrinol Metab 12:360-5. 2001
    ..PGC-1 could therefore allow coordinated regulation of transcription and splicing in response to signals relaying metabolic needs. These novel findings are discussed in the context of the proposed physiological functions of PGC-1...
  53. ncbi Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1
    P Puigserver
    Dana Farber Cancer Institute, Department of Cell Biology, Boston, MA 02115, USA
    Mol Cell 8:971-82. 2001
    ..These data illustrate a direct thermogenic action of cytokines and p38 MAP kinase through the transcriptional coactivator PGC-1...
  54. ncbi Peroxisome proliferator-activated receptor-gamma coactivator-1 gene locus: associations with obesity indices in middle-aged women
    Harald Esterbauer
    Department of Laboratory Medicine, Landeskliniken Salzburg, Austria
    Diabetes 51:1281-6. 2002
    Peroxisome proliferator-activated receptor-gamma coactivator-1 (PPARGC1) is a transcriptional coactivator that has been implicated in the regulation of genes involved in energy metabolism...
  55. ncbi A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes
    K Hara
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Japan
    Diabetologia 45:740-3. 2002
    ..Thus, PGC-1 can be viewed as a functional and positional candidate for the susceptibility gene for Type II (non-insulin-dependent) diabetes mellitus...
  56. ncbi Identification of a specific molecular repressor of the peroxisome proliferator-activated receptor gamma Coactivator-1 alpha (PGC-1alpha)
    Masaru Ichida
    Laboratory of Molecular Biology, Cardiovascular Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Biol Chem 277:50991-5. 2002
    ..In addition, our results suggest that other co-activators might also have specific repressors, thereby identifying another layer of combinatorial complexity in transcriptional regulation...
  57. ncbi Ligand and coactivator identity determines the requirement of the charge clamp for coactivation of the peroxisome proliferator-activated receptor gamma
    Yifei Wu
    Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    J Biol Chem 278:8637-44. 2003
    ....
  58. pmc Exercise induces transient transcriptional activation of the PGC-1alpha gene in human skeletal muscle
    Henriette Pilegaard
    Copenhagen Muscle Research Centre and The August Krogh Institute, University of Copenhagen, Denmark
    J Physiol 546:851-8. 2003
    ..Consistent with its role as a transcriptional coactivator, these findings suggest that PGC-1alpha may coordinate the activation of metabolic genes in human muscle in response to exercise...
  59. ncbi Peroxisome proliferator-activated receptor-gamma coactivator-1 gene locus: associations with hypertension in middle-aged men
    Hannes Oberkofler
    Department of Laboratory Medicine, Landeskliniken, Salzburg, Austria
    Hypertension 41:368-72. 2003
    Peroxisome proliferator-activated receptor-gamma coactivator-1 (PPARGC1/PGC-1) is a transcriptional coactivator of nuclear hormone receptors implicated in blood pressure regulation...
  60. ncbi Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator
    Pere Puigserver
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115
    Endocr Rev 24:78-90. 2003
    ..Finally, PGC-1 alpha's control of energy homeostasis suggests that it could be a target for anti-obesity or diabetes drugs...
  61. ncbi Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription factor FKHR
    Hiroaki Daitoku
    Center for Tsukuba Advanced Research Alliance, Institute of Applied Biochemistry, University of Tsukuba, Tennoudai 1 1 1, Tsukuba, Ibaraki 305 8577, Japan
    Diabetes 52:642-9. 2003
    ..These results indicate that signaling via PKB to FKHR can partly account for the effect of insulin to regulate the PGC-1 promoter activity via the IRSs...
  62. ncbi A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor gamma coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians
    Yunhua Li Muller
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease NIH, 4212 N 16th Street, Phoenix, AZ 85016, USA
    Diabetes 52:895-8. 2003
    ..These data indicate that the Gly482Ser missense polymorphism in PGC-1 has metabolic consequences on lipid metabolism that could influence insulin secretion...
  63. pmc Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1
    Mary Elizabeth Patti
    Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 100:8466-71. 2003
    ..is decreased only in diabetic subjects, expression of both PPAR gamma coactivator 1-alpha and-beta (PGC1-alpha/PPARGC1 and PGC1-beta/PERC), coactivators of NRF-1 and PPAR gamma-dependent transcription, is decreased in both diabetic ..
  64. ncbi PGC-1alpha mRNA expression is influenced by metabolic perturbation in exercising human skeletal muscle
    Jessica Norrbom
    Department of Physiology and Pharmacology, Section of Molecular Exercise Physiology, Karolinska Institutet, 171 77 Stockholm, Sweden
    J Appl Physiol (1985) 96:189-94. 2004
    ..This suggests that calcineurin may be activated by exercise in humans and does not exclude that calcineurin could play a role in PGC-1 transcription activation in human skeletal muscle...
  65. ncbi PGC-1alpha activates CYP7A1 and bile acid biosynthesis
    Dong Ju Shin
    Department of Molecular Biology and Biochemistry, University of California, Irvine California 92697 3900, USA
    J Biol Chem 278:50047-52. 2003
    ..Our studies provide further evidence of the fundamental role played by PGC-1alpha in oxidative metabolism and define PGC-1alpha as a link between diabetes and bile acid metabolism...
  66. ncbi Endurance training in humans leads to fiber type-specific increases in levels of peroxisome proliferator-activated receptor-gamma coactivator-1 and peroxisome proliferator-activated receptor-alpha in skeletal muscle
    Aaron P Russell
    Clinique romande de réadaptation, Suva, Sion, Switzerland Endocrine Unit, University Hospital Geneva, Geneva, Switzerland
    Diabetes 52:2874-81. 2003
    ..001). The increases in PGC-1 and PPAR-alpha levels reported in this study may play an important role in the changes in muscle mitochondria content, oxidative phenotype, and sensitivity to insulin known to be induced by endurance training...
  67. pmc Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK
    Melina Fan
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 18:278-89. 2004
    ..The discovery of p160MBP as a PGC-1alpha regulator has important implications for the understanding of energy balance and diabetes...
  68. ncbi Studies of the Gly482Ser polymorphism of the peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) gene in Danish subjects with the metabolic syndrome
    Louise Ambye
    Department of Clinical Biochemistry, Hvidovre University Hospital, Kettegaards Alle 30, DK 2650 Hvidovre, Copenhagen, Denmark
    Diabetes Res Clin Pract 67:175-9. 2005
    ..In conclusion, the Gly482Ser polymorphism of the PGC-1alpha gene is not associated with the metabolic syndrome, related quantitative traits or cardiac hypertrophy among Danish Caucasian subjects...
  69. ncbi PPARGC1A genotype (Gly482Ser) predicts exceptional endurance capacity in European men
    Alejandro Lucia
    European University of Madrid, Spain
    J Appl Physiol (1985) 99:344-8. 2005
    Animal and human data indicate a role for the peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PPARGC1A) gene product in the development of maximal oxygen uptake (V(O2 max)), a determinant of endurance capacity, ..
  70. ncbi PGC-1alpha Gly482Ser polymorphism associates with hypertension among Danish whites
    Gitte Andersen
    Steno Diabetes Center, Niels Steensens Vej 2, NSH2 16, DK 2820 Gentofte, Denmark
    Hypertension 45:565-70. 2005
    ..001). In conclusion, the Ser allele of PGC-1alpha Gly482Ser confers a significantly reduced risk of hypertension in whites. Further studies are needed to elucidate the differential role of this polymorphism in men and women...
  71. ncbi Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
    Joseph T Rodgers
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 434:113-8. 2005
    ..Thus, we have identified a molecular mechanism whereby SIRT1 functions in glucose homeostasis as a modulator of PGC-1alpha. These findings have strong implications for the basic pathways of energy homeostasis, diabetes and lifespan...
  72. ncbi Effects of the peroxisome proliferator-activated receptor-gamma co-activator-1 Gly482Ser variant on features of the metabolic syndrome
    Marie Claude Vohl
    Lipid Research Center, CHUL Research Center, Quebec City, Que, Canada
    Mol Genet Metab 86:300-6. 2005
    ..Peroxisome proliferator-activated receptor-gamma co-activator-1 (PPARGC1) is a transcriptional co-activator of many nuclear receptors including PPAR-gamma, involved in the regulation of ..
  73. ncbi Peroxisome proliferator-activated receptor-gamma co-activator-1alpha (PGC-1alpha) gene polymorphisms and their relationship to Type 2 diabetes in Asian Indians
    K S Vimaleswaran
    Madras Diabetes Research Foundation, Gopalapuram and Dr Mohans M V Diabetes Specialities Centre, 4 Conran Smith Road, Gopalapuram, Chennai 600 086, India
    Diabet Med 22:1516-21. 2005
    ....
  74. pmc The Gly482Ser missense mutation of the peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1 alpha) gene associates with reduced insulin sensitivity in normal and glucose-intolerant obese subjects
    Marzia Fanelli
    Department of Clinical Sciences, Division of Endocrinology, University of Rome La Sapienza, Rome, Italy
    Dis Markers 21:175-80. 2005
    ..This association resulted independent from all other known modulators of insulin resistance, and suggests a primary role for the PGC-1alpha gene on the genetic susceptibility to insulin resistance in obesity...
  75. ncbi Effect of polymorphisms in the PPARGC1A gene on body fat in Asian Indians
    K S Vimaleswaran
    Madras Diabetes Research Foundation, Gopalapuram and Dr Mohan s Diabetes Specialities Centre, Chennai, India
    Int J Obes (Lond) 30:884-91. 2006
    To evaluate whether polymorphisms in the peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PPARGC1A) gene were related to body fat in Asian Indians.
  76. ncbi Impaired coactivator activity of the Gly482 variant of peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) on mitochondrial transcription factor A (Tfam) promoter
    Yon Sik Choi
    Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, Republic of Korea
    Biochem Biophys Res Commun 344:708-12. 2006
    ..These results suggest that PGC-1alpha variants with Gly/Gly at 482nd amino acid may impair the Tfam transcription, a regulatory function of mitochondrial biogenesis, resulting in dysfunctional mtDNA replication...
  77. ncbi Associations of PPARGC1A haplotypes with plaque score but not with intima-media thickness of carotid arteries in middle-aged subjects
    Bernhard Iglseder
    Paracelsus Private Medical University, Salzburg
    Stroke 37:2260-5. 2006
    Peroxisome proliferator activated receptor gamma coactivator 1alpha (PGC-1alpha, PPARGC1A) integrates the transcriptional program of mitochondrial biogenesis...
  78. ncbi Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism
    Christophe Handschin
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Endocr Rev 27:728-35. 2006
    ..Recent studies have elucidated the function of the PGC-1 coactivators in different tissues and have highlighted the implications of PGC-1 dysregulation in diseases such as diabetes, obesity, cardiomyopathy, or neurodegeneration...
  79. ncbi PGC-1alpha induces apoptosis in human epithelial ovarian cancer cells through a PPARgamma-dependent pathway
    Yan Zhang
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China
    Cell Res 17:363-73. 2007
    ..Our findings indicated that PGC-1alpha was involved in the apoptotic signal transduction pathways and downregulation of PGC-1alpha may be a key point in promoting epithelial ovarian cancer growth and progression...
  80. ncbi PGC-1alpha Thr394Thr and Gly482Ser variants are significantly associated with T2DM in two North Indian populations: a replicate case-control study
    Audesh Bhat
    National Centre of Applied Human Genetics, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India
    Hum Genet 121:609-14. 2007
    The recent observations that Peroxisome proliferator activated receptor gamma coactivator 1 alpha (PGC1A) is responsible for the induction of reactive oxygen species (ROS) detoxifying agents and that ROS triggers insulin resistance, ..
  81. ncbi The peroxisome proliferator-activated receptor gamma coactivator-1 alpha gene (PGC-1alpha) is not associated with type 2 diabetes mellitus or body mass index among Hispanic and non Hispanic Whites from Colorado
    T L Nelson
    Department of Health and Exercise Science, Colorado State University, Fort Collins, CO 80523, USA
    Exp Clin Endocrinol Diabetes 115:268-75. 2007
    ..In conclusion, we did not find an association between the PGC-1alpha gene and T2DM or BMI and there were no consistent interactions with diet, physical activity or the Pro12Ala polymorphism of the PPAR-gamma gene...
  82. ncbi Polymorphisms of the peroxisome proliferator-activated receptor-gamma coactivator-1alpha gene are associated with hypertrophic cardiomyopathy and not with hypertension hypertrophy
    Shuxia Wang
    Sino German Laboratory for Molecular Medicine, Key Laboratory for Clinical Cardiovascular Genetics of the Ministry of Education, Beijing, PR China
    Clin Chem Lab Med 45:962-7. 2007
    ..The aim of our study was to identify the association between PGC-1alpha gene polymorphisms and cardiac hypertrophy...
  83. ncbi Interaction between the UCP2-866G/A, mtDNA 10398G/A and PGC1alpha p.Thr394Thr and p.Gly482Ser polymorphisms in type 2 diabetes susceptibility in North Indian population
    E Rai
    National Centre of Applied Human Genetics, School of Life Sciences, Jawaharlal Nehru University, New Delhi, 110067, India
    Hum Genet 122:535-40. 2007
    ..59, 5.53-13.35 at 95% CI), showed a highly significant difference and increased ORs. In a complex disease, it is always encouraging to find an additive interaction of multiple small effects of the studied candidate gene variations...
  84. pmc PPARGC1A variation associated with DNA damage, diabetes, and cardiovascular diseases: the Boston Puerto Rican Health Study
    Chao Qiang Lai
    Nutrition and Genomics Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, USA
    Diabetes 57:809-16. 2008
    ..We sought to link peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PPARGC1A), a master transcriptional regulator of mitochondrial oxidative phosphorylation and cellular energy metabolism, ..
  85. pmc Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion
    C Ling
    Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, CRC, 205 02 Malmo, Sweden
    Diabetologia 51:615-22. 2008
    ..coactivator peroxisome proliferator activated receptor gamma coactivator-1 alpha (protein PGC-1alpha; gene PPARGC1A) is a master regulator of mitochondrial genes and its expression is decreased and related to impaired oxidative ..
  86. doi Genetic study between SIRT1, PPARD, PGC-1alpha genes and Alzheimer's disease
    S Helisalmi
    Institute of Clinical Medicine, Unit of Neurology and Brain Research Unit, Clinical Research Center, Mediteknia, Kuopio University, PL 1627, 70211 Kuopio, Finland
    J Neurol 255:668-73. 2008
    ..We conclude that there is no real association with SNPs available in the present study between SIRT1, PPARD or PGC-1alpha genes and AD risk in the Finnish population...
  87. pmc The Gly482Ser genotype at the PPARGC1A gene and elevated blood pressure: a meta-analysis involving 13,949 individuals
    Karani Santhanakrishnan Vimaleswaran
    Department of Public Health and Clinical Medicine, Umea University Hospital, Umea, Sweden
    J Appl Physiol (1985) 105:1352-8. 2008
    The protein encoded by the PPARGC1A gene is expressed at high levels in metabolically active tissues and is involved in the control of oxidative stress via reactive oxygen species detoxification...
  88. doi Association between PPARGC1A gene polymorphisms and coronary artery disease in a Chinese population
    Yan Zhang
    Atherosclerosis Research Center, Jiangsu Province, Nanging Medical University, Nanjing, China
    Clin Exp Pharmacol Physiol 35:1172-7. 2008
    Peroxisome proliferrator-activated receptor gamma coactivator-1alpha (PGC-1alpha; PPARGC1A) is a coactivator of the nuclear hormone receptor family that participates in the transcriptional programme of lipid metabolism and oxidative ..
  89. doi Rapid exercise-induced changes in PGC-1alpha mRNA and protein in human skeletal muscle
    Anila S Mathai
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    J Appl Physiol (1985) 105:1098-105. 2008
    ..The beta-isoform declined rather than increasing, and this was greater when glycogen was not resynthesized to rest levels...
  90. pmc AMPK and PPARdelta agonists are exercise mimetics
    Vihang A Narkar
    Gene Expression Laboratory, Salk Institute, La Jolla, CA 92037, USA
    Cell 134:405-15. 2008
    ..These results demonstrate that AMPK-PPARdelta pathway can be targeted by orally active drugs to enhance training adaptation or even to increase endurance without exercise...
  91. pmc AMP-activated protein kinase-regulated activation of the PGC-1alpha promoter in skeletal muscle cells
    Isabella Irrcher
    Department of Biology, York University, Toronto, Ontario, Canada
    PLoS ONE 3:e3614. 2008
    ..Our data identify a novel AMPK-mediated regulatory pathway that regulates PGC-1alpha gene expression. This could represent a potential therapeutic target to control PGC-1alpha expression in skeletal muscle...
  92. pmc PGC-1alpha is a key regulator of glucose-induced proliferation and migration in vascular smooth muscle cells
    Lingyun Zhu
    Jiangsu Diabetes Center, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, People s Republic of China
    PLoS ONE 4:e4182. 2009
    ..This study was performed to investigate whether PGC-1alpha, a PPARgamma coactivator and metabolic master regulator, plays a role in regulating VSMC proliferation and migration induced by high glucose...
  93. pmc PGC-1alpha as modifier of onset age in Huntington disease
    Elahe Taherzadeh-Fard
    Department of Human Genetics, Ruhr University, 44780 Bochum, Germany
    Mol Neurodegener 4:10. 2009
    ..Our data suggest that PGC-1alpha has modifying effects on the pathogenic process in HD...
  94. pmc PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia
    Weiping Qin
    Department of Psychiatry, Mount Sinai School of Medicine, Bronx, NY, USA
    Arch Neurol 66:352-61. 2009
    ....
  95. doi Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density
    Romain Barres
    Department of Molecular Medicine and Surgery, Section for Integrative Physiology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    Cell Metab 10:189-98. 2009
    ..We provide evidence for PGC-1alpha hypermethylation, concomitant with reduced mitochondrial content in type 2 diabetic patients, and link DNMT3B to the acute fatty-acid-induced non-CpG methylation of PGC-1alpha promoter...
  96. pmc Peroxisome proliferator-activated receptor gamma Coactivator 1alpha and small heterodimer partner differentially regulate nuclear receptor-dependent hepatitis B virus biosynthesis
    Caitlin R Ondracek
    Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, 909 South Wolcott Avenue, Chicago, Illinois 60612, USA
    J Virol 83:12535-44. 2009
    ..Additionally, this functional approach may help to distinguish the transcription factors in various liver cells governing viral biosynthesis under a variety of physiologically relevant conditions...
  97. doi Peroxisome proliferator-activated receptor-gamma coactivator 1-alpha overexpression prevents endothelial apoptosis by increasing ATP/ADP translocase activity
    Jong Chul Won
    Department of Internal Medicine, University of Ulsan College of Medicine, Seoul, Korea
    Arterioscler Thromb Vasc Biol 30:290-7. 2010
    ..This study was undertaken to investigate the possible preventive effect of PGC-1alpha on endothelial apoptosis and its molecular mechanism...
  98. doi Relative workload determines exercise-induced increases in PGC-1alpha mRNA
    Nikolai Baastrup Nordsborg
    Copenhagen Muscle Research Centre, University of Copenhagen, Denmark
    Med Sci Sports Exerc 42:1477-84. 2010
    ..The hypothesis that brief intermittent exercise-induced increases in human skeletal muscle metabolic mRNA is dependent on relative workload was investigated...
  99. doi The p65 subunit of NF-kappaB binds to PGC-1alpha, linking inflammation and metabolic disturbances in cardiac cells
    David Alvarez-Guardia
    Department of Pharmacology and Therapeutic Chemistry, IBUB Institut de Biomedicina de Universitat de Barcelona Instituto de Salud Carlos III, Faculty of Pharmacy, University of Barcelona, Diagonal 643, Barcelona E 08028, Spain
    Cardiovasc Res 87:449-58. 2010
    ....
  100. pmc Exercise intensity-dependent regulation of peroxisome proliferator-activated receptor coactivator-1 mRNA abundance is associated with differential activation of upstream signalling kinases in human skeletal muscle
    Brendan Egan
    School of Health and Human Performance, Dublin City University, Dublin 9, Ireland
    J Physiol 588:1779-90. 2010
    ..This effect is mediated by differential activation of multiple signalling pathways, with ATF-2 and HDAC phosphorylation proposed as key intensity-dependent mediators...
  101. pmc PGC-1alpha down-regulation affects the antioxidant response in Friedreich's ataxia
    Daniele Marmolino
    Laboratoire de Neurologie Expérimentale, Universite Libre de Bruxelles, Brussels, Belgium
    PLoS ONE 5:e10025. 2010
    ....

Research Grants71

  1. Activity Dependent Signaling in Adult Skeletal Muscle Fiber Plasticity
    Martin F Schneider; Fiscal Year: 2012
    ....
  2. Min You; Fiscal Year: 2016
    ....
  3. Regulation and Function of the Rhox5 Homeobox Gene
    MILES FROME WILKINSON; Fiscal Year: 2013
    ..Other Rhox5-regulated genes include those encoding the key metabolic regulators PPAR?, PGC1?, resistin, and adiponectin, as well other members of the X-linked Rhox homeobox gene cluster...
  4. Bruce M Spiegelman; Fiscal Year: 2016
    ..Previous work on this grant has shown that the transcriptional coactivator PGC1[unreadable] is induced with exercise in muscle and gives muscle many of the attributes seen in this tissue with ..
  5. S Russ Price; Fiscal Year: 2015
    ..To accomplish this goal, we must first understand the biochemical basis for dysregulation of PGC1a during CKD-induced wasting...
  6. Pere Puigserver; Fiscal Year: 2016
    ..Among the transcriptional regulators of these mitochondrial processes are the PGC1 family of coactivators and transcription factors including Nuclear Respiratory Factors, Hormone Nuclear Receptors ..
  7. Regulation of Skeletal Muscle Angiogenesis by PGC-1 alpha
    Srilatha Raghuram; Fiscal Year: 2012
    ..I propose to investigate if this pathway can form functional blood vessels, protect against muscle damage from blocked blood vessels and henceforth provide a new therapeutic approach to this debilitating disease. ..
  8. Satyanarayana Ande; Fiscal Year: 2015
    ..adipose tissue (BAT), and Id1-deficiency in mice resulted in enhanced thermogenesis due to induced expression of PGC1[unreadable] and UCP1, critical regulators of thermogenesis...
  9. Hei Sook Sul; Fiscal Year: 2016
    ..element is found in the promoter regions of other BAT-enriched genes, and we detected binding and activation of PGC1[unreadable] promoter by B2. B2 expression is increased during brown adipocyte differentiation...
  10. Rev-ERBa Regulates Mitochondrial Biogenesis, Adiposity, and Insulin Action
    Thomas H Reynolds; Fiscal Year: 2010
    ..Rev-ERBa represses the expression of peroxisome proliferator-activated receptor-gamma (PPAR?) coactivator 1 alpha (PGC1a), a master regulator of mitochondrial biogenesis...
  11. Effects of Dietary Fat on Contractile and Mitochondrial Function in Heart Failure
    Margaret P Chandler; Fiscal Year: 2010
    ....
  12. Mitoenergetic Failure in Brain Aging
    Gregory J Brewer; Fiscal Year: 2013
    ..in insulin signaling and decrease in transcriptional activators in the peroxisome proliferator family, especially PGC1a, PPAR? and NRF, also known to stimulate mitochondrial biogenesis...
  13. FINR: A Novel Modulator of Insulin Signaling
    Marc R Montminy; Fiscal Year: 2010
    ..fibers, focusing on the potential involvement of the nuclear hormone receptor PPAR delta and the coactivator PGC1a in this process...
  14. Ryan M Whitaker; Fiscal Year: 2015
    ..Additionally, mRNA expression of PGC1- [unreadable], as well as complex I proteins ND6 and NDUFB8 was increased...
  15. The Regulation of Mitochondrial Function by SIRT3
    Qiang Tong; Fiscal Year: 2010
    ..3) To characterize the effect of SIRT3 on mitochondrial superoxide production and hyperglycemia-induced oxidative stress. 4) To investigate the effect of SIRT3 on adipose oxidative stress during obesity and diabetes in vivo. ..
  16. Bruce M Spiegelman; Fiscal Year: 2016
    ..b>PGC1a regulates mitochondrial biogenesis and oxidative metabolism in many tissues, and links these genetic programs to ..
  17. Interactions for Pesticides, mitochondria and genetics in Parkinson's disease.
    M Flint Beal; Fiscal Year: 2010
    ..The study will enrich and refine our understanding of pesticide-induced cell damage pathways observed in sporadic and familial PD and identify new target(s) for intervention in PD pathogenesis. ..
  18. Raj M Lakshman; Fiscal Year: 2015
    ..down regulations of silence regulator gene 1 (SIRT1) and peroxisome proliferator receptor coactivator 1 (PGC1) 1 and up-regulation of PGC1beta affect hepatic lipid oxidation and lipogenesis leading to fatty liver and ..
  19. Oxaloacetate's Brain Effects
    Russell H Swerdlow; Fiscal Year: 2013
    ..In mice, we found systemically administered OAA increased brain PGC1a levels...
  20. Zoltan P Arany; Fiscal Year: 2016
    ..Integral to this pathway are two transcriptional coactivators, PGC-1a (ppargc1a) and its close relative PGC-1[unreadable] (ppargc1b)...
  21. Sara E Pinney; Fiscal Year: 2015
    ..Expression of PPARGC1A (PGC1[unreadable]), a transcriptional coactivator that regulates mitochondrial function, is decreased in both ..
  22. Structural and functional studies of the nuclear receptor PPARgamma
    H Eric Xu; Fiscal Year: 2010
    ..provide the first view of PPAR? bound to a natural ligand;2) the PPAR? LBD in complex with the PPAR? coactivator PGC1a;and 3) a PPAR? DBD-hinge-LBD fragment bound to RXR and a DNA of the PPAR response element (PPRE)...
  23. Novel Paradigms in Diabetic Complications
    Kumar Sharma; Fiscal Year: 2011
    ..We will also identify if epigenetic modification of the PGC1a promoter may underlie the reduction in mitochondrial function in patients and in animal models...
  24. Jonathan Sebat; Fiscal Year: 2015
    ..of our aims is supported by the track record of the first iteration of the Psychiatric GWAS Consortium ("PGC1") where we united nearly all major groups in the field into a harmonious and functional entity and completed our ..
  25. Peter A Calabresi; Fiscal Year: 2016
    ..PPAR[unreadable] in OPCs, and this occurs in association with increased pSTAT6 and expression of the coactivator PGC1a in a heteromeric complex with TRb1. IFN[unreadable] suppresses this pathway...
  26. Douglas G Mashek; Fiscal Year: 2015
    ..base this hypothesis on Preliminary Studies from our laboratory showing that ATGL induces Sirt1 activity to control PGC1-A/PPAR-a signaling, mediates the effects of B-adrenergic signaling on Sirt1/PGC1- a/PPAR-a signaling, and induces ..
  27. Sophia Y Tsai; Fiscal Year: 2016
    ..Interestingly, we also showed reduced expression of PGC1/ and ERR/, thus strongly implicating COUP-TFII as a regulator for controlling the PGC/ERR axis to alter fuel usage ..
  28. Geoffrey D Girnun; Fiscal Year: 2016
    ..We recently showed that loss of the transcriptional coactivator PGC1 greatly reduced chemically induced hepatocellular carcinogenesis...
  29. DGAT1 Mediated Cardiac Steatosis
    DENIS J GLENN; Fiscal Year: 2013
    ..a reduction in expression of the deacetylase SIRT1 and the second aim will explore the role of SIRT1 and PGC1 alpha in mediating the effects of lipid deposition and cardiac myocyte dysfunction...
  30. Junichi Sadoshima; Fiscal Year: 2016
    ..This project has significant implications for Public Health because knowledge obtained from this study should be useful for the development of a novel treatment for HF in patients. ..
  31. Expression reporter mice for non-invasive imaging: PGC-1a and Huntington's Diseas
    Peter J Detloff; Fiscal Year: 2012
    ..We have designed a strategy applicable to any gene which will first be tested on the mouse PGC1? locus given the many known means of regulating its gene expression...
  32. GENETIC AND PHYSIOLOGICAL REGULATION IN BROWN ADIPOCYTES
    Michael Sitrin; Fiscal Year: 2004
    ..Specific aim 2 will examine the regulation of a novel BAT coactivator PGC1. Specific aim 3 examines the role of cAMP and retinoic acid response elements in mediating the response to cold ..
  33. Anti-aging effects of PGC-1 alpha expression
    Walter Ward; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  34. Mechanisms for Fetal Hepatic Programming during Intrauterine Growth Restriction
    Stephanie Thorn; Fiscal Year: 2009
    ..Our preliminary data also show that the SIRT1 deacetylase and its gluconeogenic target PGC1-alpha are up-regulated in the IUGR fetal liver...
  35. Pharmacogenetics of Diabetes Prevention
    Richard Watanabe; Fiscal Year: 2009
    ..X receptor-a (RXRA) a critical co-factor for PPARG;and peroxisome proliferator-activated receptor-g coactivatoMa (PPARGC1A) a critical regulator of the PPARG-stimulated pathway...
  36. Regulation of SNS-dependent Remodeling of Adipose Tissue by a Novel Form of PGC-1
    Thomas W Gettys; Fiscal Year: 2010
    ..Evidence has emerged to support the view that PGC1 is the critical transcriptional co-activator linking p-adrenergic receptors to transcriptional programs which have ..
  37. PGC-1 Co-Activators in Cardiac Metabolism and Function
    Zoltan Arany; Fiscal Year: 2009
    ..The nuclear receptor co-activator PPAR-Gamma Co-activator 1 (PGC1)-alpha is a well-established global regulator of energy homeostasis in numerous tissues;strong evidence suggests ..
  38. Functional Analysis of PGC1-a holo-complex in Diabetes
    Marcus Cooper; Fiscal Year: 2009
    ..of sound principles and expertise for studying the transcriptional co-activator, PPAR gamma co-activator 1 alpha (PGC1-alpha), as it pertains to metabolism. Bruce M. Spiegelman, Ph.D...
  39. Genomic Approaches to Understanding Metabolism and Aging
    ALEXANDRA CHAROS; Fiscal Year: 2009
    ..abstract_text> ..
  40. Metabolic Regulation of Reactive Oxygen Species
    Jessica Silvaggi; Fiscal Year: 2007
    ..Our findings will clarify the role of PGC-1 alpha during the transcription of several important ROS detoxifying enzymes, and help to reveal any link to ROS-related diseases. [unreadable] [unreadable] [unreadable]..
  41. Regulation of Transcription by AMPK
    Yilan Li; Fiscal Year: 2010
    ..a known AMPK target and PEPCK transcriptional regulator) and alters its interaction with the coactivator PGC1-alpha...
  42. GENCAC - Utah Field Center
    Steven Hunt; Fiscal Year: 2004
    ..abstract_text> ..
  43. Physiology of Malonyl-CoA in Muscle during Exercise
    WILLIAM WINDER; Fiscal Year: 2006
    ..The results will provide additional rationale for the use of regular exercise in preventing and treating type 2 diabetes and obesity. ..
  44. PPARs and LXR Regulate Epidermal Differentiation
    Kenneth Feingold; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  45. MYOD AND MYOGENIN IN MUSCLE HYPERTROPHY AND SARCOPENIA
    STEPHEN ALWAY; Fiscal Year: 2001
    ....
  46. Id2 REGULATION OF MUSCLE HYPERTROPHY IN AGING
    STEPHEN ALWAY; Fiscal Year: 2007
    ..abstract_text> ..
  47. ApoB-Proteoglycan Interaction and Atherosclerosis
    Zhouji Chen; Fiscal Year: 2006
    ..Such information will advance our understanding of mechanisms of atherosclerosis and, in turn, facilitate developing new therapeutic strategies to treat atherosclerotic diseases. [unreadable] [unreadable]..
  48. Ketone Dysregulation and Muscle Insulin Resistance
    DEBORAH MUOIO; Fiscal Year: 2006
    ..abstract_text> ..
  49. Genetic Architecture of Aging Skeletal Muscle
    Stephen Roth; Fiscal Year: 2005
    ..abstract_text> ..
  50. The Family Blood Pressure Program (HyperGEN Network)
    Steven Hunt; Fiscal Year: 2007
    ..unreadable] (End of Abstract) [unreadable] [unreadable]..
  51. Endocrine pancreatic cell regeneration from bone marrow
    Mehboob A Hussain; Fiscal Year: 2010
    ..4) To identify the cell type within BM that contributes to the pancreatic endocrine cell population. The long-term goal of these studies is to evaluate transplantation of BM derived cells as a potential treatment for diabetes mellitus. ..
  52. Regulation of Skeletal Muscle LKB1
    WILLIAM WINDER; Fiscal Year: 2010
    ..The proposed studies will provide additional rationale for convincing a predominantly sedentary population of the importance of regular exercise in combating inactivity-related diseases. ..
  53. ISOLATION OF A HYPERCHOLESTEROLEMIA RESISTANCE GENE
    Karen Reue; Fiscal Year: 2002
    ..In addition, we compare Bailey and J substrains for susceptibility to aortic lesion development, as a model in which similar HDL levels occur in conjunction with vastly different LDL/VLDL levels. ..
  54. MULTIPLE SEVERE OBESITY RISK GENES IN UTAH PEDIGREES
    Steven Hunt; Fiscal Year: 2009
    ..Validation will be tested in a large case/control series, Polynesian families, and, for chromosome 20, in the congenic mouse model. ..
  55. Mechanisms linking the adipogenic phenotype of aging muscle to insulin resistance
    Deborah M Muoio; Fiscal Year: 2010
    ....
  56. Genetic Aspects of Vestibular Dysfunction
    Stephen Roth; Fiscal Year: 2004
    ..The proposed project will generate important pilot data related to the genetics of vestibular dysfunction, thus fitting within the R21 grant mechanism. ..
  57. TRANSCRIPTIONAL CONTROL OF COLON CANCER THROUGH PPARY
    Bruce Spiegelman; Fiscal Year: 2004
    ..Since PPAR-gamma ligands are clinically available now, this work may provide a framework in which to contemplate new therapeutic approaches to colon cancer. ..
  58. CCCTC-binding factor (CTCF) in trinucleotide repeat instability and disease
    Albert R La Spada; Fiscal Year: 2010
    ..Finally, we will attempt to validate the function of the antisense non-coding RNA in vivo. ..
  59. Validation of C. elegans "fat genes" in the mouse
    Karen Reue; Fiscal Year: 2005
    ..This pilot study will reveal whether "fat genes" identified in the invertebrate C. elegans have a similar role in mammals, and may identify novel genes involved in fat storage and metabolism. ..
  60. Stratum Corneum Acidification in the Neonate
    Kenneth Feingold; Fiscal Year: 2007
    ..4) To determine if activators of PPAR alpha, PPAR delta, and/or LXR accelerate the formation of an acidic SC, the mechanism for this acceleration of acidification, and the functional consequences of such an acceleration. ..
  61. Mitochondrial Biogenesis and Neuroprotection
    RITA COWELL; Fiscal Year: 2005
    ..These experiments will address fundamental questions in neurobiology while revealing mechanisms of neuronal survival that could lead to new treatments for patients with neurological disorders. ..
  62. Effects of Psychological Stress on the Stratum Corneum
    Kenneth Feingold; Fiscal Year: 2008
    ..Aim 4: To determine if the abnormalities in permeability barrier homeostasis and SC integrity/ cohesion induced by GC treatment in humans, are due to the inhibition of epidermal lipid synthesis. ..
  63. Somatic support cell function in gonad development
    GERRIT BOUMA; Fiscal Year: 2006
    ..The proposed experiments will identify genes expressed in gonadal SSCs that play a role in gonadal XY sex reversal. ..
  64. GENETIC EPIDEMIOLOGY OF AGING IN UTAH PEDIGREES
    Steven Hunt; Fiscal Year: 2007
    ..This collection of longitudinally followed pedigrees provides a powerful study design to address a wide range of genetic epidemiological analyses of aging. ..
  65. Gene Expression in Prediabetes: Potential Role of PGC-1
    MARY PATTI; Fiscal Year: 2006
    ..abstract_text> ..
  66. Genetic Epidemiology of Aging Skeletal Muscle
    Stephen Roth; Fiscal Year: 2007
    ..abstract_text> ..