PPARgamma

Summary

Gene Symbol: PPARgamma
Description: peroxisome proliferator activated receptor gamma
Alias: CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma, peroxisome proliferator-activated receptor gamma, PPAR-gamma, nuclear receptor subfamily 1 group C member 3, peroxisome proliferator-activated nuclear receptor gamma variant 1
Species: human

Top Publications

  1. ncbi Isolation of the human peroxisome proliferator activated receptor gamma cDNA: expression in hematopoietic cells and chromosomal mapping
    M E Greene
    UCLA School of Medicine, Department of Medicine 90024, USA
    Gene Expr 4:281-99. 1995
  2. pmc Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
    Eleftheria Zeggini
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Genet 40:638-45. 2008
  3. doi Reduced beta-catenin and peroxisome proliferator-activated receptor-gamma expression levels are associated with colorectal cancer metastatic progression: correlation with tumor-associated macrophages, cyclooxygenase 2, and patient outcome
    Massimo Pancione
    Department of Biological and Environmental Sciences, University of Sannio, 82100 Benevento, Italy
    Hum Pathol 40:714-25. 2009
  4. ncbi T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities
    Gary Lee
    Tularik Inc, South San Francisco, California 94080, USA
    J Biol Chem 277:19649-57. 2002
  5. ncbi Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor
    P Tontonoz
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115
    Cell 79:1147-56. 1994
  6. ncbi PPARgamma activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties
    M Amine Bouhlel
    Institut Pasteur de Lille, F 59019 Lille, France INSERM, U545, F 59019 Lille, France
    Cell Metab 6:137-43. 2007
  7. ncbi The effects of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 gene on insulin sensitivity and insulin metabolism interact with size at birth
    Johan G Eriksson
    Department of Epidemiology and Health Promotion, Diabetes and Genetic Epidemiology Unit, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Diabetes 51:2321-4. 2002
  8. pmc Pro12Ala polymorphism in the PPARG gene contributes to the development of diabetic nephropathy in Chinese type 2 diabetic patients
    Limei Liu
    Department of Endocrinology and Metabolism, Shanghai JiaoTong University Affiliated Sixth People s Hospital, Shanghai Diabetes Institute, Shanghai, China
    Diabetes Care 33:144-9. 2010
  9. doi Regulation of the human endogenous retroviral Syncytin-1 and cell-cell fusion by the nuclear hormone receptors PPARγ/RXRα in placentogenesis
    Matthias Ruebner
    Department of Gynaecology and Obstetrics, University Clinic Erlangen, Erlangen, Germany
    J Cell Biochem 113:2383-96. 2012
  10. pmc A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
    Laura J Scott
    Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    Science 316:1341-5. 2007

Research Grants

  1. The function(s) and regulation of PPARs in the ovary
    Carolyn Komar; Fiscal Year: 2003
  2. TRANSCRIPTIONAL CONTROL OF COLON CANCER THROUGH PPARY
    Bruce Spiegelman; Fiscal Year: 2004
  3. Association of PPAR gamma ligands & colonic neoplasia
    James Lewis; Fiscal Year: 2006
  4. Mechanisms Regulating Reversal of Malignancy
    Priscilla Furth; Fiscal Year: 2009
  5. The effects of allelic variation in Pparg on skeletal metabolism
    Cheryl Ackert Bicknell; Fiscal Year: 2007
  6. Sean Hartig; Fiscal Year: 2015
  7. Synergistic Roles of Adiponectin & PPARgamma in Beta-Cell Survival/Proliferation
    William L Holland; Fiscal Year: 2010
  8. Mechanisms of Brd2 immunoprotection from insulin resistance
    Gerald V Denis; Fiscal Year: 2011
  9. Virtual Screening Development to Complement Experimental Screening for PPAR Modul
    Stephanie N Lewis; Fiscal Year: 2012
  10. Yuqing Eugene Chen; Fiscal Year: 2016

Detail Information

Publications374 found, 100 shown here

  1. ncbi Isolation of the human peroxisome proliferator activated receptor gamma cDNA: expression in hematopoietic cells and chromosomal mapping
    M E Greene
    UCLA School of Medicine, Department of Medicine 90024, USA
    Gene Expr 4:281-99. 1995
    ..85-kb full-length cDNA encoding a new human member of this superfamily, the peroxisome proliferator activated receptor gamma (hPPAR gamma)...
  2. pmc Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
    Eleftheria Zeggini
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Genet 40:638-45. 2008
    ..1 x 10(-9)), ADAMTS9 (P = 1.2 x 10(-8)) and NOTCH2 (P = 4.1 x 10(-8)) gene regions. Our results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D...
  3. doi Reduced beta-catenin and peroxisome proliferator-activated receptor-gamma expression levels are associated with colorectal cancer metastatic progression: correlation with tumor-associated macrophages, cyclooxygenase 2, and patient outcome
    Massimo Pancione
    Department of Biological and Environmental Sciences, University of Sannio, 82100 Benevento, Italy
    Hum Pathol 40:714-25. 2009
    ..This finding may provide a relevant prognostic tool and contribute to early identification of patients at high risk of mortality...
  4. ncbi T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities
    Gary Lee
    Tularik Inc, South San Francisco, California 94080, USA
    J Biol Chem 277:19649-57. 2002
    The nuclear hormone receptor peroxisome proliferator-activated receptor gamma (PPARgamma (NR1C3)) plays a central role in adipogenesis and is the molecular target for the thiazolidinedione (TZD) class of antidiabetic drugs...
  5. ncbi Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor
    P Tontonoz
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115
    Cell 79:1147-56. 1994
    Peroxisome proliferator-activated receptor gamma 2 (PPAR gamma 2) is an adipocyte-specific nuclear hormone receptor that has recently been identified as a key regulator of two fat cell enhancers...
  6. ncbi PPARgamma activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties
    M Amine Bouhlel
    Institut Pasteur de Lille, F 59019 Lille, France INSERM, U545, F 59019 Lille, France
    Cell Metab 6:137-43. 2007
    ..Here we show that in human atherosclerotic lesions, the expression of M2 markers and PPARgamma, a nuclear receptor controlling macrophage inflammation, correlate positively...
  7. ncbi The effects of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 gene on insulin sensitivity and insulin metabolism interact with size at birth
    Johan G Eriksson
    Department of Epidemiology and Health Promotion, Diabetes and Genetic Epidemiology Unit, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Diabetes 51:2321-4. 2002
    ..We suggest that these findings reflect gene-environment interaction...
  8. pmc Pro12Ala polymorphism in the PPARG gene contributes to the development of diabetic nephropathy in Chinese type 2 diabetic patients
    Limei Liu
    Department of Endocrinology and Metabolism, Shanghai JiaoTong University Affiliated Sixth People s Hospital, Shanghai Diabetes Institute, Shanghai, China
    Diabetes Care 33:144-9. 2010
    ..To determine whether the Pro12Ala polymorphism, alone or in combination with smoking, contributes to the development of diabetic nephropathy, a case-control study was performed in 760 Chinese patients with type 2 diabetes...
  9. doi Regulation of the human endogenous retroviral Syncytin-1 and cell-cell fusion by the nuclear hormone receptors PPARγ/RXRα in placentogenesis
    Matthias Ruebner
    Department of Gynaecology and Obstetrics, University Clinic Erlangen, Erlangen, Germany
    J Cell Biochem 113:2383-96. 2012
    ..Our study characterized PPARγ/RXRα signaling in human CT and cell fusions identifying Syncytin-1 as a new target gene. Based on these results, a disturbed PPARγ/RXRα pathway could contribute to pathological human pregnancies...
  10. pmc A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
    Laura J Scott
    Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    Science 316:1341-5. 2007
    ..This brings the number of T2D loci now confidently identified to at least 10...
  11. ncbi Role of genetic polymorphism peroxisome proliferator-activated receptor-gamma2 Pro12Ala on ethnic susceptibility to diabetes in South-Asian and Caucasian subjects: Evidence for heterogeneity
    Venkatesan Radha
    Department of Molecular Genetics, Madras Diabetes Research Foundation, Dr Mohan s Diabetes Specialties Centre, No 4, Conran Smith Road, Gopalapuram, Chennai 86, India
    Diabetes Care 29:1046-51. 2006
    ..To determine whether the peroxisome proliferator-activated receptor (PPAR)-gamma Pro12ala polymorphism modulates susceptibility to diabetes in South Asians...
  12. pmc Ala/Ala genotype of Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-γ2 gene is associated with obesity and insulin resistance in Asian Indians
    Surya Prakash Bhatt
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    Diabetes Technol Ther 14:828-34. 2012
    ..We determined the association of the Pro12Ala polymorphism of the peroxisome proliferator activated receptor (PPAR)-γ2 gene with obesity, insulin resistance (IR), and lipids in Asian Indians without diabetes in north India...
  13. ncbi PPARG F388L, a transactivation-deficient mutant, in familial partial lipodystrophy
    Robert A Hegele
    Blackburn Cardiovascular Genetics Laboratory, Robarts Research Institute, 406 100 Perth Drive, London, Ontario, Canada N6A 5K8
    Diabetes 51:3586-90. 2002
    ..Our findings are consistent with the idea that mutant PPARG can underlie the partial lipodystrophy phenotype...
  14. pmc Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes
    Hong Ping Guan
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, The Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 19:453-61. 2005
    Peroxisome proliferator-activated receptor gamma (PPARgamma) is the master regulator of adipogenesis as well as the target of thiazolidinedione (TZD) antidiabetic drugs...
  15. pmc Xanthine oxidoreductase promotes the inflammatory state of mononuclear phagocytes through effects on chemokine expression, peroxisome proliferator-activated receptor-{gamma} sumoylation, and HIF-1{alpha}
    Sophie Gibbings
    Division of Pulmonary Sciences, Division of Pulmonary Sciences, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Biol Chem 286:961-75. 2011
    ....
  16. doi Associations of receptor for advanced glycation end products -374 T/A and Gly82 Ser and peroxisome proliferator-activated receptor gamma Pro12Ala polymorphisms in Turkish coronary artery disease patients
    Hulya Yilmaz Aydogan
    Department of Molecular Medicine, The Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey
    Genet Test Mol Biomarkers 16:134-7. 2012
    ....
  17. pmc Peroxisome proliferator-activated receptor γ polymorphism Pro12Ala Is associated with nephropathy in type 2 diabetes: evidence from meta-analysis of 18 studies
    Hui Zhang
    Division of Geriatric Nephrology, Medical and Health Care Center, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing, China
    Diabetes Care 35:1388-93. 2012
    ..The association between the polymorphism and DN risk has also been widely studied recently, but no consensus was available up to now...
  18. doi Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score--the CoLaus Study
    X Lin
    Discovery Analytics, GlaxoSmithKline, Collegeville, PA, USA
    Diabetologia 52:600-8. 2009
    ....
  19. ncbi Cyclooxygenase-independent induction of apoptosis by sulindac sulfone is mediated by polyamines in colon cancer
    Naveen Babbar
    Arizona Cancer Center, and Biochemistry, Molecular and Cellular Biology Graduate Program, The University of Arizona, Tucson, 85724, USA
    J Biol Chem 278:47762-75. 2003
    ..transcription start site, is required for the induction of SSAT by sulindac sulfone and is specifically bound by PPAR gamma in the Caco-2 cells as shown by transfection and gel shift experiments...
  20. doi Deletion of PPAR gamma in alveolar macrophages is associated with a Th-1 pulmonary inflammatory response
    Anagha Malur
    Department of Internal Medicine, Division of Pulmonary and Critical Care and Sleep Medicine, East Carolina University, Greenville, NC 27834, USA
    J Immunol 182:5816-22. 2009
    Peroxisome proliferator-activated receptor gamma (PPARgamma) is constitutively expressed at high levels in healthy alveolar macrophages, in contrast to other tissue macrophages and blood monocytes...
  21. ncbi Role of interaction between variants in the PPARG and interleukin-6 genes on obesity related metabolic risk factors
    M Barbieri
    Department of Geriatric Medicine and Metabolic Diseases II, University of Naples, VI Divisione di Medicina Interna, Napoli, Italy
    Exp Gerontol 40:599-604. 2005
    ..13 +/- 0.92; f = 4.342; p = 0.038) and triglyceride levels (79.15 +/- 32.9 vs 98 +/- 6.73 mg/dl; f = 3.120; p < 0.005). These findings suggest that the effect of the two genetic variants on 'obesity related' factors is additive...
  22. doi Gender-specific effect of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma-2 gene on obesity risk and leptin levels in a Tunisian population
    Samir Ben Ali
    Research Laboratory LR99ES11, Biochemistry Department, Rabta University Hospital, Tunis, Tunisia
    Clin Biochem 42:1642-7. 2009
    ..the impact of the Pro12Ala (rs1801282) polymorphism of the peroxisome proliferator-activated receptor gamma-2 (PPARgamma-2) gene on obesity or body mass index (BMI) and plasma leptin, insulin, adiponectin and lipid levels in a sample ..
  23. ncbi Single-nucleotide polymorphisms in peroxisome proliferator-activated receptor gamma and their association with plasma levels of resistin and the metabolic syndrome in a South Indian population
    Abdul Haseeb
    Molecular Biology Unit, National Institute of Nutrition, Jamai Osmania, Hyderabad 500 604, India
    J Biosci 34:405-14. 2009
    ..1% to 75.4%, P=0.037). Plasma resistin levels were not found to be associated with MS and type 2 diabetes. These results point to a likely association of plasma resistin levels with PPAR? polymorphisms in the Indian population...
  24. pmc Relationship of APOA5, PPARγ and HL gene variants with serial changes in childhood body mass index and coronary artery disease risk factors in young adulthood
    Lakshmy Ramakrishnan
    Department of Cardiac Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    Lipids Health Dis 10:68. 2011
    ..We analysed polymorphisms in APOA5, hepatic lipase and PPARγ genes and investigated their association with birth weight and serial changes in BMI...
  25. doi Association of PPAR-γ gene polymorphisms with obesity and obesity-associated phenotypes in North Indian population
    Jai Prakash
    Chatrapati Shahuji Maharaj Medical University, Lucknow, U P, India
    Am J Hum Biol 24:454-9. 2012
    ..In this study, we investigated the association of PPAR-γ gene Pro12Ala (rs1801282) and C1431T (rs3856806) polymorphisms with morbid obesity and related phenotypes, in north Indian population...
  26. pmc PPAR-γ2 and PTPRD gene polymorphisms influence type 2 diabetes patients' response to pioglitazone in China
    Qi Pei
    Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha, China
    Acta Pharmacol Sin 34:255-61. 2013
    ....
  27. doi The C161T polymorphism in the peroxisome proliferator-activated receptor gamma gene (PPARγ) is associated with risk of coronary artery disease: a meta-analysis
    Zhijun Wu
    Department of Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, Ruijin Second Road 197, Shanghai 200025, China
    Mol Biol Rep 40:3101-12. 2013
    ..11, P = 0.913). Taken together, our results revealed the PPARγ C161T polymorphism might play a moderate protective effect on developing CAD among Chinese, but not among Caucasians...
  28. pmc The Pro12Ala polymorphism in the peroxisome proliferator-activated receptor gamma-2 gene (PPARγ2) is associated with increased risk of coronary artery disease: a meta-analysis
    Zhijun Wu
    Department of Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    PLoS ONE 7:e53105. 2012
    ..Contradictory results have been reported regarding the association between Pro12Ala polymorphism of PPARγ2 and coronary artery disease (CAD). We sought to estimate the inconsistent results by performing a comprehensive meta-analysis...
  29. pmc Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR alpha
    P Tontonoz
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115
    Nucleic Acids Res 22:5628-34. 1994
    ..the ARF6 complex as a heterodimer of the retinoid X receptor alpha (RXR alpha) and the murine peroxisome proliferator activated receptor gamma (PPAR gamma)...
  30. ncbi Cardiovascular risk in type 2 diabetes is associated with variation at the PPARG locus: a Go-DARTS study
    Alex S F Doney
    Institute for Cardiovascular Research, Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee, Scotland
    Arterioscler Thromb Vasc Biol 24:2403-7. 2004
    ..We therefore investigated the association of these 2 variants with cardiovascular events in people with type 2 diabetes...
  31. ncbi Common polymorphisms in the PPARgamma2 and IRS-1 genes and their interaction influence serum adiponectin concentration in young Finnish men
    Firoozeh Mousavinasab
    Department of Public Health Science and General Practice, University of Oulu, Aapistie 1, P O Box 5000, Oulu 90014, Finland
    Mol Genet Metab 84:344-8. 2005
    ..We conclude that the Ala12Ala genotype of PPARgamma2 is associated with elevated adiponectin level, and that the PPARgamma2 and IRS-1 genes have a possible interaction in their effects on adiponectin concentration...
  32. ncbi Analysis of separate and combined effects of common variation in KCNJ11 and PPARG on risk of type 2 diabetes
    Sara K Hansen
    Steno Diabetes Center and Hagedorn Research Institute, Niels Steensens Vej 2, DK 2820 Gentofte, Denmark
    J Clin Endocrinol Metab 90:3629-37. 2005
    ..In conclusion, our results showed no evidence of a synergistic interaction between the KCNJ11 Glu(23)Lys and PPARG Pro(12)Ala polymorphisms, but indicated that they may act in an additive manner to increase the risk of type 2 diabetes...
  33. pmc Enterococcus faecalis from newborn babies regulate endogenous PPARgamma activity and IL-10 levels in colonic epithelial cells
    Alexandra Are
    Department of Microbiology and Tumor and Cell Biology, Karolinska Institute, S 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 105:1943-8. 2008
    ..The involvement of PPARgamma1 in a myriad of physiological processes further confirms that microflora-driven regulation might be important for a number of homeostatic strategies in the gut...
  34. pmc Hair follicle stem cell-specific PPARgamma deletion causes scarring alopecia
    Pratima Karnik
    Department of Dermatology, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Invest Dermatol 129:1243-57. 2009
    ..Specific agonists of PPARgamma are effective in inducing peroxisomal and lipid metabolic gene expression in human keratinocytes...
  35. doi Maternal pregestational BMI is associated with methylation of the PPARGC1A promoter in newborns
    Carolina Gemma
    Molecular Genetics and Biology of Complex Diseases Department, Institute of Medical Research, A Lanari, University of Buenos Aires CONICET, Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
    Obesity (Silver Spring) 17:1032-9. 2009
    ..In conclusion, our findings suggest a potential role of promoter PPARGC1A methylation in metabolic programming...
  36. doi Repression of NHE1 expression by PPARgamma activation is a potential new approach for specific inhibition of the growth of tumor cells in vitro and in vivo
    Alan Prem Kumar
    Departments of Physiology, National University Medical Institutes, Yong Loo Lin School of Medicine, Singapore
    Cancer Res 69:8636-44. 2009
    Ligand-induced activation of peroxisome proliferator-activated receptor gamma (PPARgamma) inhibits proliferation in cancer cells in vitro and in vivo; however, the downstream targets remain undefined...
  37. pmc Cross species comparison of C/EBPα and PPARγ profiles in mouse and human adipocytes reveals interdependent retention of binding sites
    Søren F Schmidt
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK 5230 Odense M, Denmark
    BMC Genomics 12:152. 2011
    ..We and others have previously shown that binding sites of these two transcription factors show a high degree of overlap and are associated with the majority of genes upregulated during differentiation of murine 3T3-L1 adipocytes...
  38. doi Association between C1431T polymorphism in peroxisome proliferator-activated receptor-γ gene and coronary artery disease in Chinese Han population
    Xiang Zhou
    Department of Cardiology, the Second Affiliated Hospital of Soochow University, NO 1055 Sanxiang Road, Suzhou, Jiangsu 215004, China
    Mol Biol Rep 39:1863-8. 2012
    ..In conclusion, the PPARγ C1431T polymorphism is associated with decreased risk of CAD in Chinese Han population...
  39. doi UHRF1 coordinates peroxisome proliferator activated receptor gamma (PPARG) epigenetic silencing and mediates colorectal cancer progression
    L Sabatino
    Department of Biological, Geological and Environmental Sciences, University of Sannio, Benevento, Italy
    Oncogene 31:5061-72. 2012
    ..These findings suggest that the relationship between UHRF1 and PPARG may have a relevant role in CRC progression...
  40. ncbi Isolation and characterization of a transcriptional cofactor and its novel isoform that bind the deoxyribonucleic acid-binding domain of peroxisome proliferator-activated receptor-gamma
    Takuya Tomaru
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi 371 8511, Japan
    Endocrinology 147:377-88. 2006
    ..identified to interact with PPARalpha and termed PPARalpha-interacting cofactor 285 (here referred to as PPARgamma-DBD-interacting protein 1 (PDIP1)-alpha). PDIP1 mRNA was expressed in 3T3-L1 adipocytes and THP-1 macrophages...
  41. ncbi The relationship of the peroxisome proliferator-activated receptor-gamma 2 exon 2 and exon 6 gene polymorphism in Turkish type 2 diabetic patients with and without nephropathy
    M Erdogan
    Ege University Medical School, Department of Endocrinology and Metabolism Disease, 35100 Izmir, Turkey
    Diabetes Res Clin Pract 78:355-9. 2007
    Peroxisome proliferator-activated receptor gamma (PPAR gamma) has recently been shown to be associated with type 2 diabetes...
  42. doi The PPAR gamma 2 Pro12Ala variant predicts ESRD and mortality in patients with type 1 diabetes and diabetic nephropathy
    A Jorsal
    Steno Diabetes Center, Niels Steensens Vej 2, 2820 Gentofte, Denmark
    Mol Genet Metab 94:347-51. 2008
    ..4 years [mean+/-SD], duration of diabetes 28.3+/-8.8 years, GFR 66+/-8.8 ml/min) and 428 patients with longstanding type 1 diabetes and persistent normoalbuminuria (230 men; age 45.4+/-11.6 years, duration of diabetes 27.8+/-10.1 years)...
  43. ncbi Polymorphism of peroxisome proliferator-activated receptor gamma is not associated to Japanese ulcerative colitis
    Fangyu Wang
    Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake, Japan
    Hepatogastroenterology 55:73-5. 2008
    Expression of peroxisome proliferator-activated receptor gamma (PPARgamma) has been reported to be impaired in patients with ulcerative colitis (UC), and activation of PPARgamma is proved to inhibit the intestinal inflammation...
  44. doi Role of PPAR-gamma in the modulation of CD36 and FcgammaRII induced by LDL with low and high degrees of oxidation during the differentiation of the monocytic THP-1 cell line
    Francisco J O Rios
    Laboratórios de Imunofisiopatologia e Imunofarmacologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Brazil
    Cell Physiol Biochem 22:549-56. 2008
    ..FcgammaRII in a human monocytic cell line (THP-1), differentiated or not to macrophage, and the involvement of PPARgamma. It was found that both forms of oxLDL are able to increase the expression of CD36 and FcgammaRII and that this ..
  45. ncbi Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma (PPARgamma) gene in inflammatory bowel disease
    Ozlen Atug
    Marmara University School of Medicine, Department of Gastroenterology, Istambul, Turkey
    J Gastrointestin Liver Dis 17:433-7. 2008
    ..In this study, we aimed to explore Pro12Ala polymorphism in PPAR-gamma gene in IBD in Turkish patients...
  46. pmc Characterization of a novel polymorphism in PPARG regulatory region associated with type 2 diabetes and diabetic retinopathy in Italy
    Valerio Costa
    Institute of Genetics and Biophysics A Buzzati Traverso IGB, National Research Council CNR, Naples, Italy
    J Biomed Biotechnol 2009:126917. 2009
    ..In the analyzed population, this variant represents a genetic risk factor for developing the diabetic retinopathy, whereas Pro12Ala and C1431T do not...
  47. doi PPAR gamma protects cardiomyocytes against oxidative stress and apoptosis via Bcl-2 upregulation
    Yusheng Ren
    Department of Cardiology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China
    Vascul Pharmacol 51:169-74. 2009
    ..Peroxisome proliferator-activated receptor gamma (PPARgamma) agonists possess potent anti-inflammatory actions and have recently emerged as potential therapeutic agents for ..
  48. pmc The multiple endocrine neoplasia type 1 (MEN1) tumor suppressor regulates peroxisome proliferator-activated receptor gamma-dependent adipocyte differentiation
    Koen M A Dreijerink
    University Medical Center Utrecht, Department of Physiological Chemistry, Utrecht, The Netherlands
    Mol Cell Biol 29:5060-9. 2009
    ..As MEN1 patients frequently develop lipomas and peroxisome proliferator-activated receptor gamma (PPARgamma) is expressed in several MEN1-related tumor types, we investigated regulation of PPARgamma activity by menin...
  49. doi Distribution of peroxisome proliferator-activated receptor-gamma polymorphisms in Chinese and Dutch patients with inflammatory bowel disease
    Umid Kumar Shrestha
    Department of Gastroenterology, Wuhan University, Zhongnan Hospital, Wuhan, People s Republic of China
    Inflamm Bowel Dis 16:312-9. 2010
    ..The aims of the present study were to determine the distribution of PPAR-gamma polymorphisms Pro12Ala and C161T and to explore the association between the PPAR-gamma genotypes and phenotypes of IBD patients...
  50. pmc Impact of the PPAR-gamma2 Pro12Ala polymorphism and ACE inhibitor therapy on new-onset microalbuminuria in type 2 diabetes: evidence from BENEDICT
    Salvatore De Cosmo
    Unit of Endocrinology, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    Diabetes 58:2920-9. 2009
    ..We prospectively evaluated the association between Pro12Ala polymorphism (rs1801282) and new-onset microalbuminuria...
  51. pmc Computational identification and experimental validation of PPRE motifs in NHE1 and MnSOD genes of human
    Gireedhar Venkatachalam
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    BMC Genomics 10:S5. 2009
    ..Here we computationally identified PPAR binding regions in NHE1 and MnSOD. We further validated the predictions in vitro...
  52. pmc Proline cis/trans-isomerase Pin1 regulates peroxisome proliferator-activated receptor gamma activity through the direct binding to the activation function-1 domain
    Yoshito Fujimoto
    The Takara Bio Endowed Division, Department of Biomolecular Recognition, Institute for Protein Research, Osaka University, Open Laboratories of Advanced Bioscience and Biotechnology, 6 2 3 Furuedai, Suita, Osaka 565 0874, Japan
    J Biol Chem 285:3126-32. 2010
    The important roles of a nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) are widely accepted in various biological processes as well as metabolic diseases...
  53. pmc The association between the peroxisome proliferator-activated receptor-gamma2 (PPARG2) Pro12Ala gene variant and type 2 diabetes mellitus: a HuGE review and meta-analysis
    Hebe N Gouda
    Department of Public Health and Primary Care, University ofCambridge, Cambridge CB2 0SR, UK
    Am J Epidemiol 171:645-55. 2010
    ..Work on PPARG Pro12Ala should now focus on the observed heterogeneity in the magnitude of the association between populations. Further investigations into gene-gene and gene-environment interactions may prove enlightening...
  54. pmc Peroxisome proliferator-activated receptor gamma activation is required for maintenance of innate antimicrobial immunity in the colon
    Laurent Peyrin-Biroulet
    Institut National de la Sante et de la Recherche Medicale, U795, F 59037 Lille, France
    Proc Natl Acad Sci U S A 107:8772-7. 2010
    ..The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) is essential for intestinal homeostasis in response to both dietary- and microbiota-derived signals...
  55. pmc Honokiol inhibits gastric tumourigenesis by activation of 15-lipoxygenase-1 and consequent inhibition of peroxisome proliferator-activated receptor-gamma and COX-2-dependent signals
    Shing Hwa Liu
    Institute of Toxicology, Taipei, Taiwan
    Br J Pharmacol 160:1963-72. 2010
    ..Here, we investigate the role of 15-LOX-1 induction by honokiol, a small-molecular weight natural product, in PPAR-gamma and COX-2 signalling during gastric tumourigenesis...
  56. doi PPARγ2 P12A polymorphism and albuminuria in patients with type 2 diabetes: a meta-analysis of case-control studies
    Salvatore De Cosmo
    Department of Cardiovascular, Endocrine and Metabolic Diseases, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    Nephrol Dial Transplant 26:4011-6. 2011
    ..This study investigated whether the PPARγ2 P12A polymorphism modulates the risk of albuminuria in these patients...
  57. pmc The Ras inhibitors caveolin-1 and docking protein 1 activate peroxisome proliferator-activated receptor γ through spatial relocalization at helix 7 of its ligand-binding domain
    Elke Burgermeister
    Department of Medicine II, Universitatsklinikum Mannheim, Universitat Heidelberg, Mannheim, Germany
    Mol Cell Biol 31:3497-510. 2011
    ..These results suggest a novel mechanism of PPARγ regulation by which Ras/MAPK inhibitors act as scaffold proteins that sequester and sensitize PPARγ to ligands, limiting proliferation of gastric epithelial cells...
  58. doi Lycium barbarum (Goji Berry) extracts and its taurine component inhibit PPAR-γ-dependent gene transcription in human retinal pigment epithelial cells: Possible implications for diabetic retinopathy treatment
    M K Song
    Faculty of Pharmacy, The University of Sydney, NSW 2006, Australia
    Biochem Pharmacol 82:1209-18. 2011
    ..We conclude that PPAR-γ activation by L. barbarum extract is associated with its taurine content and may explain at least in part its use in diabetic retinopathy progression...
  59. pmc PPARγ Pro12Ala and ACE ID polymorphisms are associated with BMI and fat distribution, but not metabolic syndrome
    Angela Passaro
    Department of Clinical and Experimental Medicine, Section of Internal Medicine, Gerontology and Clinical Nutrition, University of Ferrara, Ferrara, Italy
    Cardiovasc Diabetol 10:112. 2011
    ..We investigated the possible association of peroxisome proliferator-activated receptor-γ2 (PPARγ2) Pro12Ala and Angiotensin Converting Enzyme (ACE) I/D polymorphisms with MetS and interaction between these genetic variants...
  60. pmc Combining information from common type 2 diabetes risk polymorphisms improves disease prediction
    Michael N Weedon
    Department of Diabetes Research and Vascular Medicine, Peninsula Medical School, Exeter, United Kingdom
    PLoS Med 3:e374. 2006
    ..The value of analyzing multiple alleles simultaneously is not well studied. This is often because, for any given disease, very few common risk alleles have been confirmed...
  61. ncbi The adipogenic acetyltransferase Tip60 targets activation function 1 of peroxisome proliferator-activated receptor gamma
    Olivier Van Beekum
    Department of Metabolic and Endocrine Diseases, University Medical Center Utrecht, Lundlaan 6, Utrecht, The Netherlands
    Endocrinology 149:1840-9. 2008
    The transcription factor peroxisome proliferator-activated receptor gamma (PPARgamma) plays a key role in the regulation of lipid and glucose metabolism in adipocytes, by regulating their differentiation, maintenance, and function...
  62. doi Lycopene prevention of oxysterol-induced proinflammatory cytokine cascade in human macrophages: inhibition of NF-κB nuclear binding and increase in PPARγ expression
    Paola Palozza
    Institute of General Pathology, Catholic University School of Medicine, 00168 Rome, Italy
    J Nutr Biochem 22:259-68. 2011
    ..Taken all together, these data bring new information on the anti-atherogenic properties of lycopene, and on its mechanisms of action in atherosclerosis prevention...
  63. ncbi Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma
    L Nagy
    The Salk Institute of Biological Studies, Howard Hughes Medical Institute, La Jolla, California 92037, USA
    Cell 93:229-40. 1998
    ..We demonstrate here that oxLDL activates PPARgamma-dependent transcription through a novel signaling pathway involving scavenger receptor-mediated particle uptake...
  64. pmc A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma
    Gabriel Pascual
    Department of Cellular and Molecular Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Nature 437:759-63. 2005
    ..This mechanism provides an explanation for how an agonist-bound nuclear receptor can be converted from an activator of transcription to a promoter-specific repressor of NF-kappaB target genes that regulate immunity and homeostasis...
  65. ncbi Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
    Richa Saxena
    Broad Institute of Harvard and Massachusetts Institute of Technology MIT, Cambridge, MA 02142, USA
    Science 316:1331-6. 2007
    ..The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues to the pathogenesis of common diseases...
  66. ncbi Prospective study of interaction between alcohol, NSAID use and polymorphisms in genes involved in the inflammatory response in relation to risk of colorectal cancer
    Ulla Vogel
    National Research Centre for the Working Environment, Copenhagen, Denmark
    Mutat Res 624:88-100. 2007
    ..02). Moreover, an interaction between DLG5 R30Q and NSAID use was found (P for interaction=0.02). Our results do not suggest that inborn variations in the inflammatory response play any major role in risk of colorectal cancer...
  67. pmc Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA
    Vikas Chandra
    Department of Pharmacology, and Center for Molecular Design, University of Virginia Health System, 1300 Jefferson Park Avenue, Charlottesville, Virginia 22908 0735, USA
    Nature 456:350-6. 2008
    ..The PPAR-gamma LBD cooperates with both DNA-binding domains (DBDs) to enhance response-element binding. The A/B segments are highly dynamic, lacking folded substructures despite their gene-activation properties...
  68. ncbi Impaired expression of peroxisome proliferator-activated receptor gamma in ulcerative colitis
    Laurent Dubuquoy
    Equipe Propre INSERM 0114 sur la Physiopathologie des Maladies Inflammatoires Intestinales, Lille, France
    Gastroenterology 124:1265-76. 2003
    The peroxisome proliferator-activated receptor gamma (PPAR gamma) has been proposed as a key inhibitor of colitis through attenuation of nuclear factor kappa B (NF-kappa B) activity...
  69. ncbi Lack of association between the Pro12Ala polymorphism in PPAR-gamma2 gene and body weight changes, insulin resistance and chronic diabetic complications in obese patients with type 2 diabetes
    Adam Stefanski
    Department of Endocrinology, Hypertension and Metabolic Diseases, Pomeranian Medical University, Szczecin, Poland
    Arch Med Res 37:736-43. 2006
    ....
  70. pmc Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor gamma activity
    Carole Berruyer
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, 13288 Marseille Cedex 9, France
    J Exp Med 203:2817-27. 2006
    ..We further demonstrate that Vanin-1, by antagonizing PPARgamma, licenses the production of inflammatory mediators by intestinal epithelial cells...
  71. ncbi Alanine variant of the Pro12Ala polymorphism of the PPARgamma gene might be associated with decreased risk of diabetic retinopathy in type 2 diabetes
    Maciej T Malecki
    Department of Metabolic Diseases, Jagiellonian University Medical College, 15 Kopernika Street, 31 501 Krakow, Poland
    Diabetes Res Clin Pract 80:139-45. 2008
    ..Molecular background of diabetic retinopathy (DR) remains unknown. An interesting group of candidate genes encode proteins involved in insulin resistance...
  72. doi Genetic polymorphisms differently influencing the emergence of atrophy and fat accumulation in HIV-related lipodystrophy
    Barbara Zanone Poma
    Department of Clinical Sciences, Luigi Sacco Hospital, University of Milan, Milan, Italy
    AIDS 22:1769-78. 2008
    ..of Fas -670 AG polymorphism, ApoC3 -455 CT and -482 CT polymorphisms, C161T silent substitution in the PPAR gamma gene, the Adrenergic beta3 Receptor (ARbeta3) codon 64 TC variant, and two polymorphisms in the Adrenergic beta2 ..
  73. pmc Peroxisome proliferator-activated receptor-gamma abrogates Smad-dependent collagen stimulation by targeting the p300 transcriptional coactivator
    Asish K Ghosh
    Feinberg Cardiovascular Research Institute, Chicago, IL 60611, USA
    FASEB J 23:2968-77. 2009
    ..Pharmacological activation of PPAR-gamma thus may represent a novel therapeutic approach to target p300-dependent TGF-beta profibrotic responses such as stimulation of collagen gene expression...
  74. ncbi Expression of PAX8-PPAR gamma 1 rearrangements in both follicular thyroid carcinomas and adenomas
    Ana Rita Marques
    Centro de Investigação de Patobiologia Molecular, Instituto Portugues de Oncologia Francisco Gentil, 1099 023 Lisboa Codex, Portugal
    J Clin Endocrinol Metab 87:3947-52. 2002
    ..In this study, we have combined RT-PCR with primers in exons 4-8 of PAX8 and in exon 1 of PPAR gamma 1 with PPAR gamma immunohistochemistry to study PAX8-PPAR gamma 1 oncogene activation in FTC (n = 9), FTA (n = ..
  75. pmc Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk
    Hana Lango
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
    Diabetes 57:3129-35. 2008
    ..Here, we assess the ability of 18 confirmed type 2 diabetes variants to differentiate between type 2 diabetic case and control subjects...
  76. ncbi PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL
    P Tontonoz
    The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Cell 93:241-52. 1998
    ..We demonstrate here that the nuclear receptor PPARgamma is induced in human monocytes following exposure to oxLDL and is expressed at high levels in the foam cells of ..
  77. ncbi The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes
    D Altshuler
    Whitehead Institute MIT Center for Genome Research, Cambridge, Massachusetts, USA
    Nat Genet 26:76-80. 2000
    ..one association, that of the common Pro12Ala polymorphism in peroxisome proliferator-activated receptor-gamma(PPARgamma) with type 2 diabetes. By analysing over 3,000 individuals, we found a modest (1.25-fold) but significant (P=0...
  78. ncbi Peroxisome proliferator-activated receptor gamma induces a phenotypic switch from activated to quiescent hepatic stellate cells
    Saswati Hazra
    Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033, USA
    J Biol Chem 279:11392-401. 2004
    Depletion of peroxisome proliferator-activated receptor gamma (PPARgamma) accompanies myofibroblastic transdifferentiation of hepatic stellate cells (HSC), the primary cellular event underlying liver fibrogenesis...
  79. pmc Joint effects of common genetic variants on the risk for type 2 diabetes in U.S. men and women of European ancestry
    Marilyn C Cornelis
    Harvard School of Public Health, Channing Laboratory, Boston, MA 02115, USA
    Ann Intern Med 150:541-50. 2009
    ..Genome-wide association studies have identified novel type 2 diabetes loci, each of which has a modest impact on risk...
  80. ncbi Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism
    Carole Brendel
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre Nationale de la Recherche Scientifique INSERM Université Louis Pasteur, BP 163, 67404 Illkirch, France
    Mol Endocrinol 16:1367-77. 2002
    ..e. the liver receptor homolog 1, the liver X receptor alpha, and PPARgamma. MBF-1 interacts with distinct domains in these receptors, depending on whether the receptor binds DNA as a ..
  81. ncbi Peroxisome proliferator-activated receptor gamma gene polymorphism is associated with serum triglyceride levels and body mass index in Japanese type 2 diabetic patients
    Atsuko Maeda
    Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine, Hongo 2 1 1, Bunkyo ku, Tokyo 113 8421, Japan
    J Clin Lab Anal 18:317-21. 2004
    Peroxisome proliferator-activated receptor gamma (PPARgamma) controls adipocyte differentiation and regulates lipid and glucose homeostasis. Therefore, the PPARgamma gene may affect insulin sensitivity and resistance...
  82. ncbi Ajulemic acid, a synthetic nonpsychoactive cannabinoid acid, bound to the ligand binding domain of the human peroxisome proliferator-activated receptor gamma
    Andre L B Ambrosio
    Centro de Biotecnologia Molecular Estrutural, Instituto de Fisica de Sao Carlos, Universidade de Sao Paulo, São Carlos SP CEP 13560 970, Brazil
    J Biol Chem 282:18625-33. 2007
    ..that AJA binds directly and selectively to the isotype gamma of the peroxisome proliferator-activated receptor (PPARgamma) suggesting that this may be a pharmacologically relevant receptor for this compound and a potential target for ..
  83. ncbi Association of PPARG2 Pro12Ala variant with larger body mass index in Mestizo and Amerindian populations of Mexico
    S Canizales-Quinteros
    Unidad de Biología Molecular y Medicina Genómica, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico
    Hum Biol 79:111-9. 2007
    ..studies have sought to associate the Pro12Ala variant of the peroxisome proliferator-activated receptor gamma2 (PPARG2) gene with type 2 diabetes, insulin resistance, and obesity, with controversial results...
  84. doi Human scavenger receptor class B type 1 is regulated by activators of peroxisome proliferators-activated receptor-gamma in hepatocytes
    Rania Abdel Muneem Ahmed
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe Miki cho, Kita gun, Kagawa 761 0793, Japan
    Endocrine 35:233-42. 2009
    ....
  85. pmc PPARgamma Pro12Ala polymorphism and risk of acute coronary syndrome in a prospective study of Danes
    Ulla Vogel
    National Food Institute, Technical University of Denmark, Søborg, Denmark
    BMC Med Genet 10:52. 2009
    ..Peroxisome proliferator-activated receptor gamma (PPARgamma) plays a key role in the regulation of the energy balance, adipocyte differentiation and lipid biosynthesis...
  86. pmc No association of multiple type 2 diabetes loci with type 1 diabetes
    S M Raj
    Cambridge Institute for Medical Research, University of Cambridge, UK
    Diabetologia 52:2109-16. 2009
    ..11 at a false-positive rate of 0.003...
  87. ncbi Peroxisome proliferator-activated receptor gamma C161T polymorphisms and survival of Japanese patients with immunoglobulin A nephropathy
    J Song
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi Dori, Niigata, Japan
    Clin Genet 64:398-403. 2003
    Peroxisome proliferator-activated receptor gamma (PPAR gamma) plays an important role in lipid metabolism, insulin sensitivity, atherogenesis, and immune regulation...
  88. doi The PPAR-gamma Pro12Ala polymorphism associates with weight gain during GH-treatment in short children born small for gestational age
    Sandra W K de Kort
    Division of Endocrinology, Department of Paediatrics, Erasmus University Medical Center, Sophia Children s Hospital, Rotterdam, The Netherlands
    Eur J Endocrinol 162:49-52. 2010
    ..The Pro12Ala polymorphism of the peroxisome proliferator-activated receptor (PPAR-gamma) gene is inversely associated with body mass index (BMI), changes in BMI and the risk to develop type 2 diabetes mellitus...
  89. doi Association of serum lipid/lipoprotein with Pro12Ala polymorphism in PPAR-γ2 among Chinese nonagenarians/centenarians
    Huang Chang-Quan
    Department of Geriatrics, The Third Hospital of Mianyang, Mianyang, China
    Arch Med Res 42:613-9. 2011
    ..We examined whether the polymorphism continued to be associated with abnormal levels of serum lipid/lipoprotein among elderly subjects (≥90 years)...
  90. doi Association between the Pro12Ala polymorphism of PPAR-γ gene and the polycystic ovary syndrome: a meta-analysis of case-control studies
    Hong Zhang
    Department of Endocrinology, Drum Tower Clinical Medical College of Nanjing Medical University, Nanjing, China
    Gene 503:12-7. 2012
    ..29; 95%CI, -0.82-0.24; p=0.29). This meta-analysis supported that PPAR-γ2 Pro12Ala polymorphism was capable of reducing polycystic ovary syndrome risk in Europeans, but not in Asians...
  91. ncbi Evidence for genetic epistasis in human insulin resistance: the combined effect of PC-1 (K121Q) and PPARgamma2 (P12A) polymorphisms
    R Baratta
    Department of Internal and Specialist Medicine, University of Catania, Garibaldi Hospital, P zza S M di Gesù, 95123 Catania, Italy
    J Mol Med (Berl) 81:718-23. 2003
    ..e., insulin sensitivity index and M value) and insulin secretion (i.e., HOMA-B%) indexes...
  92. ncbi Pro12Ala sequence variant of the PPARG gene is associated with postprandial hypertriglyceridemia in non-E3/E3 patients with the metabolic syndrome
    Fernando Cardona
    Servicio de Endocrinología y Nutrición Hospital Clínico Virgen de la Victoria de Málaga, Malaga, Spain
    Clin Chem 52:1920-5. 2006
    ..Variations in these genes may affect postprandial hypertriglyceridemia in the context of the metabolic syndrome...
  93. ncbi PPARgamma2 Pro12Ala polymorphism in relation to free fatty acids concentration and composition in lean healthy Czech individuals with and without family history of diabetes type 2
    B Bendlova
    Institute of Endocrinology, Prague, Czech Republic
    Physiol Res 57:S77-90. 2008
    ....
  94. pmc Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk
    Dharambir K Sanghera
    Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    BMC Med Genet 9:59. 2008
    ..the role of 9 most significant SNPs reported in GWA studies: [peroxisome proliferator-activated receptor gamma 2 (PPARG2; rs 1801282); insulin-like growth factor two binding protein 2 (IGF2BP2; rs 4402960); cyclin-dependent kinase 5, a ..
  95. doi Interaction between PPARG Pro12Ala and ADIPOQ G276T concerning cholesterol levels in childhood obesity
    Lovisa E Johansson
    Department of Clinical Sciences Malmo, Clinical Obesity, Lund University, CRC, UMAS, Ing 72, Hus 91, Plan 12, Malmo S 205 02, Sweden
    Int J Pediatr Obes 4:119-25. 2009
    ..The aim of this study was to investigate the role of two candidate gene polymorphisms for insulin resistance and lipid levels in obese children and adolescents...
  96. pmc Lack of association between peroxisome proliferator-activated receptors alpha and gamma2 polymorphisms and progressive liver damage in patients with non-alcoholic fatty liver disease: a case control study
    Paola Dongiovanni
    Department of Internal Medicine, Metabolic Liver Diseases Research Center, Universita degli Studi di Milano, Fondazione Ospedale Policlinico Ca Granda IRCCS, Milano, Italy
    BMC Gastroenterol 10:102. 2010
    ..Peroxisome proliferator-activated receptors (PPARs) play key roles in the pathogenesis of nonalcoholic fatty liver disease (NAFLD)...
  97. ncbi Analysis of two sequence variants in peroxisome proliferator-activated receptor gamma gene in a Tibetan population at high altitude and a Han population at low altitude in China
    Xiao Ling Liu
    Chinese Academy of Medical Sciences, Beijing, China
    Med Sci Monit 16:CR458-63. 2010
    ..In this study we analyzed the Pro12Ala (C>G) polymorphism in exon 2 and the 161C>T polymorphism in exon 6 of peroxisome proliferator-activated receptor gamma gene (PPARγ) in a Tibetan population and a Han population...
  98. doi Amerindians show no association of PPAR-γ2 gene Ala12 allele and obesity: an "unthrifty" variant population genetics
    Antonio Arnaiz-Villena
    Departamento de Inmunologia, Facultad de Medicina, The Madrid Regional Blood Center, University Complutense, Pabellon 5, planta 4 Avda Complutense s n, 28040, Madrid, Spain
    Mol Biol Rep 40:1767-74. 2013
    ..This may suggest that appearance of Ala12 allele occurred after populations adapted to an agricultural feeding...
  99. doi Elevated levels of PPAR-gamma in the cerebrospinal fluid of patients with multiple sclerosis
    Levente Szalárdy
    Department of Neurology, University of Szeged, Semmelweis u 6, H 6725 Szeged, Hungary
    Neurosci Lett 554:131-4. 2013
    ..Corroborating with prior experimental findings, these results may contribute to our understanding about the role of PPARγ in MS, and may implicate this protein as a potential CSF biomarker of the disease. ..
  100. doi Effect of interaction between PPARG, PPARA and ADIPOQ gene variants and dietary fatty acids on plasma lipid profile and adiponectin concentration in a large intervention study
    Aseel AlSaleh
    Diabetes and Nutritional Sciences Division, School of Medicine, King s College London, 150 Stamford Street, London SE1 9NH, UK
    Proc Nutr Soc 71:141-53. 2012
    ..In conclusion, in Whites, high dietary PUFA:SFA would help to reduce plasma cholesterol and TAG in PPARG Ala12 carriers. In ADIPOQ -10066 GG homozygotes, a high-MUFA diet may help to increase adiponectin with advancing age...
  101. doi Quantitative evaluation of common polymorphism (rs1801282) in the PPARγ2 gene and hypertension susceptibility
    Yujun Wang
    Department of Clinical Laboratory, The First Hospital of Jiaxing, Jiaxing 314001, China
    Gene 502:159-62. 2012
    ..63, 95%CI 0.46-0.86) but not among Caucasians (Ala/Ala+Pro/Ala vs. Pro/Pro: OR=0.72, 95%CI 0.38-1.38). The results indicated the significant association of PPARγ2 rs1801282 polymorphism with hypertension susceptibility among East Asians...

Research Grants68

  1. The function(s) and regulation of PPARs in the ovary
    Carolyn Komar; Fiscal Year: 2003
    ..b>PPAR gamma has been shown to play a role in angiogenesis, inflammation, cell differentiation, and steroidogenesis...
  2. TRANSCRIPTIONAL CONTROL OF COLON CANCER THROUGH PPARY
    Bruce Spiegelman; Fiscal Year: 2004
    ..Since PPAR-gamma ligands are clinically available now, this work may provide a framework in which to contemplate new therapeutic approaches to colon cancer. ..
  3. Association of PPAR gamma ligands & colonic neoplasia
    James Lewis; Fiscal Year: 2006
    ..Colonic epithelial cells express high levels of PPARgamma, protein...
  4. Mechanisms Regulating Reversal of Malignancy
    Priscilla Furth; Fiscal Year: 2009
    ..nuclear receptors Retinoid X Receptor alpha (RXRalpha) and Peroxisome proliferator-activated receptor gamma (PPARgamma). Reversal of premalignant disease is one goal of cancer prevention treatment programs...
  5. The effects of allelic variation in Pparg on skeletal metabolism
    Cheryl Ackert Bicknell; Fiscal Year: 2007
    ..term objective of this proposal is to characterize the impact of allelic variation in the Peroxisome Proliferator Activated Receptor Gamma (Pparg) gene on skeletal metabolism during activation of this nuclear receptor by dietary or ..
  6. Sean Hartig; Fiscal Year: 2015
    ..function, including fat metabolism and adipokine expression, are tightly regulated by peroxisome proliferator activated receptor gamma (PPAR?)...
  7. Synergistic Roles of Adiponectin & PPARgamma in Beta-Cell Survival/Proliferation
    William L Holland; Fiscal Year: 2010
    ..which improves insulin sensitivity through activation of peroxisome proliferator-activated receptor-gamma (PPAR gamma), a critical transcriptional mediator of adipocyte differentiation...
  8. Mechanisms of Brd2 immunoprotection from insulin resistance
    Gerald V Denis; Fiscal Year: 2011
    ..abstract_text> ..
  9. Virtual Screening Development to Complement Experimental Screening for PPAR Modul
    Stephanie N Lewis; Fiscal Year: 2012
    ....
  10. Yuqing Eugene Chen; Fiscal Year: 2016
    ....
  11. Pharmacogenomics of Thiazolidinedione Response
    Soren Snitker; Fiscal Year: 2012
    ..Insulin resistance is a central element of the metabolic syndrome, a constellation of adverse health factors that affects one in five adult Americans. ..
  12. PPAR gamma regulates vascular endothelial reactive species production in diabetes
    C Michael Hart; Fiscal Year: 2012
    ..abstract_text> ..
  13. Raphael A Nemenoff; Fiscal Year: 2015
    ....
  14. PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR EXPRESSION
    NICOLAS GUZMAN; Fiscal Year: 2001
    ..abstract_text> ..
  15. SAGAR PRADEEP BAPAT; Fiscal Year: 2014
    ..Taken together, these studies will systematically characterize the role of PPAR! in fTregs and illuminate the role of fTregs in the pathogenesis of obesity-related type-2 diabetes. ..
  16. Yihong Wan; Fiscal Year: 2015
    ..Therefore, this investigation will significantly impact the broader scientific, clinical, and patient community. ..
  17. ALEXANDER BANKS; Fiscal Year: 2014
    ....
  18. Olivier Thibault; Fiscal Year: 2016
    ..Therefore, even if the central hypothesis is rejected, the studies proposed will provide more definitive evidence for the impact o metabolic syndrome, as well as the actions of TZDs, on the brain. ..
  19. Mechanistic studies of a PPAR-g mutation that causes lipodystrophy &diabetes
    OLGA IGOR ASTAPOVA; Fiscal Year: 2013
    ..This knowledge may advance possibilities for screening, treatment and prevention of diabetes and other metabolic diseases. ..
  20. Nuclear receptor mechanisms controlling macrophage function in health and disease
    Ajay Chawla; Fiscal Year: 2013
    ..molecular, cellular, and genetic approaches, including tissue-specific knockouts, to further investigate how PPAR gamma and delta orchestrate macrophage gene expression during injury and repair...
  21. Unique Roles of p160 Coactivators during Human Adipogenesis
    Sean Hartig; Fiscal Year: 2010
    ..The findings will provide new intervention strategies to prevent the onset of obesity and the associated clinical outcomes. ..
  22. Nuclear Receptor Interactions on DNA
    Fraydoon Rastinejad; Fiscal Year: 2010
    ..The second emphasis area is directed at characterizing the ligands, structures and functions of the orphan nuclear receptors: rev-erb alpha/beta which play important roles in psychiatric and metabolic diseases. ..
  23. Validation of PPARgamma agonists as anti-dyskinetic drugs
    Alex Anthony Martinez; Fiscal Year: 2013
    ..work carried out in our laboratory on dyskinetic 6-OHDA rats indicated that activation of peroxisome proliferator activated receptor gamma (PPAR3), a member of the super family of nuclear receptors, ameliorates LID once they are ..
  24. Mitochondrial Protection Within Chronically Ischemic Myocardium
    Edward O McFalls; Fiscal Year: 2010
    ..Using this model, we propose that a class of drugs used in diabetic patients that has been associated with heart failure exacerbations, alters the mitochondrial energy production in a similar way. ..
  25. Effects of fish oil on inflammation and metabolic syndrome
    Philip A Kern; Fiscal Year: 2012
    ..Before and after treatment with fish oils, insulin sensitivity will be measured, along with intramyocellular lipid and genes or proteins involved in insulin action and muscle lipid oxidation ..
  26. PPAR gamma in pediatric sepsis and the inflammatory response in obesity
    JENNIFER MELISSA KAPLAN; Fiscal Year: 2013
    ..The proposed research is significant because it can lead to novel therapies for patients with sepsis, including the potential use of FDA-approved PPARg ligands, thiazolidinediones, which can augment the PPARg pathway. ..
  27. Regulation of Prostate Cancer Growth by PPARg Ligands
    LAMONICA VANETTE STEWART; Fiscal Year: 2010
    ..goal of this project is to define how thiazolidinediones (TZDs) and other ligands for the peroxisome proliferator activated receptor gamma (PPARg) could be used clinically to treat patients with prostate cancer...
  28. ROLE OF PPAR GAMMA IN LUPUS NEPHRITIS
    Gary Gilkeson; Fiscal Year: 2005
    ..Activators of the nuclear receptor PPAR gamma inhibit macrophage and mesangial cell activation...
  29. PPAR- GAMMA LIGANDS IN ULCERATIVE COLITIS
    James Lewis; Fiscal Year: 2001
    ..Colonic epithelial cells express high levels of PPARgamma protein and have the ability to produce inflammatory cytokines that may contribute to the inflammatory process ..
  30. BENJAMIN DOUGLAS KORMAN; Fiscal Year: 2014
    ..This work will help me to develop the knowledge and skills necessary to become an independent investigator and ultimately a future leader in rheumatology and the field of SSc research. ..
  31. Ajay Chawla; Fiscal Year: 2014
    ..dependent on the transcriptional activity of Peroxisome Proliferator Activated Receptors gamma and delta (PPAR gamma and delta), providing a mechanistic basis for the protective functions of these receptors in obesity-induced ..
  32. Role of T cells and PPARgamma in Graves' orbital fibroblast adipogenesis
    Richard P Phipps; Fiscal Year: 2010
    ..differentiation is believed to be mainly controlled by a transcription factor called peroxisome proliferator activated receptor gamma (PPARgamma)...
  33. Role of Early B Cell Factor-1 (EBF-1) in Adipocyte Biology
    Michael J Griffin; Fiscal Year: 2010
    ....
  34. S Russ Price; Fiscal Year: 2016
    ..Use of Cn inhibitors could have a negative impact on both types of patients. Lastly, our results could be broadly applicable to Veterans suffering from many types of debilitating diseases associated with atrophy. ..
  35. Vsevolod Y Polotsky; Fiscal Year: 2014
    ..abstract_text> ..
  36. Cong Yan; Fiscal Year: 2015
    ..Accomplishment of the proposed studies will elucidate the molecular mechanism by which the LAL/hormonal ligands/PPAR? axis controls anti-tumor adaptive immunity and pave the way for novel immunotherapy of lung cancer. ..
  37. CNS PPAR gamma and energy homeostasis
    HEIDI E KOCALIS; Fiscal Year: 2011
    ..If a role for PPARy in CNS controlled energy homeostasis is indicated, this will establish the brain as yet another target of PPARy agonist drugs. ..
  38. SETH BERNAT FURGESON; Fiscal Year: 2015
    ..In Aim Three, we will determine which agent can reduce neointima size the greatest after wire injury. ..
  39. Anti-angiogenic Barriers to Tumor Development
    Susan E Crawford; Fiscal Year: 2010
    ..Moreover, a significant decrease in PEDF mRNA was evident when PPAR gamma was over-expressed in rodent livers and PEDF interacted with nuclear receptors suggesting that PEDF may be a new ..
  40. Effects of High Fat Diet and Environmental Obesogen Co-Exposure on Osteoporosis
    Jennifer J Schlezinger; Fiscal Year: 2013
    ..including organotins and phthalates, are being recognized for their ability to activate peroxisome proliferator activated receptor gamma (PPAR?), the master regulator of adipocyte differentiation...
  41. John A Katzenellenbogen; Fiscal Year: 2016
    ..Their biodistribution will then be evaluated in preclinical models of ERR?-positive breast cancers to develop ERR? as a predictive marker for novel therapies for both ER-positive and negative breast cancers. ..
  42. MOLECULAR ANALYSIS OF TRANSCRIPTIONAL REPRESSION BY TGIF
    David Wotton; Fiscal Year: 2010
    ..whether TGIF and Tiull preferentially target RXR-PPARgamma complexes via a specific interaction of Tiull with PPAR gamma. Finally, we will test whether TGIF regulates cell cycle progression by blocking TGF beta mediated growth ..
  43. LXR and PPARgamma mediated Abeta clearance mechanisms
    Gary E Landreth; Fiscal Year: 2011
    ..We will test if the actions of PPARy on A clearance are secondary to, and reliant upon, LXR function. ..
  44. Nobuyo Maeda; Fiscal Year: 2016
    ..Using mouse genetics as a tool, we aim to determine how some common human genetic differences affect atherosclerosis and how the genetic effects are influenced by being overweight and by other common gene variants. ..
  45. Ashraf Gorgey; Fiscal Year: 2016
    ..The completion of the proposed experiment will allow the candidate to compete as an independent research investigator. ..
  46. MATTHEW STEINHAUSER; Fiscal Year: 2016
    ..Stable isotope methods will be used to quantitate adipogenesis after pharmacologic stimulation of PPAR-gamma with a thiazolidinedione in obese and lean mice. ..
  47. Kezhong Zhang; Fiscal Year: 2016
    ..Understanding the stress-induced molecular mechanisms in hepatic lipid accumulation and its associated pathogenesis is a key prerequisite for the development of new diagnostics and therapeutics targeting NAFLD. ..
  48. Zivar Yousefipour; Fiscal Year: 2016
    ..b>Peroxisome proliferator activated receptor gamma (PPAR?), a nuclear transcription factor, regulates inflammatory response via modulating the ..
  49. Sex Hormones and the Innate Immune Response to Influenza Infection
    DIONNE ROBINSON; Fiscal Year: 2012
    ..pro-inflammatory cytokines/chemokines can be inhibited by peroxisome proliferator-activated receptor gamma (PPARgamma) signaling which antagonizes the activation of transcription factors (e.g. NF-kappaB)...
  50. Dysregulated Pathways in Pulmonary Fibrosis
    Keith C Olsen; Fiscal Year: 2012
    ..Recently, TG2 was shown to control the function of the transcription factor peroxisome proliferator activated receptor gamma (PPAR?)...
  51. Min You; Fiscal Year: 2016
    ....
  52. Microparticles as Messengers of Communication Between Blood and Vascular Cells
    Richard P Phipps; Fiscal Year: 2010
    ..Understanding this new way of cell to cell communication will lead to new methods and biomarkers to detect disease and to new ways of delivering therapy to reduce the consequences of diabetes and other diseases. ..
  53. DAVID EMERSON GREEN; Fiscal Year: 2016
    ....
  54. Farrah Kheradmand; Fiscal Year: 2016
    ..This application captures some of the critical initiation events in smoke-induced inflammation and applies this knowledge to explore new therapeutic options in emphysema. ..
  55. Linking partial and non-agonist induced dynamics to PPAR gamma functions
    TRAVIS SHANE HUGHES; Fiscal Year: 2013
    ..g. heart failure) from wanted effects (i.e. anti-diabetic efficacy, anti-inflammation). This will improve diabetes treatment and open up possibilities for PPAR targeted therapies for atherosclerosis and autoimmune disorders. ..
  56. Echium Oil Modulates Macrophage Inflammation by Promoting Alternative Activation
    AMANDA WIBLEY; Fiscal Year: 2010
    ..The nuclear hormone receptor PPAR gamma acts as a lipid-sensor and likely directs this modulation of macrophage activation phenotypes by omega-3 fatty ..
  57. Preclinical neuroprotective trials of a PPAR-gamma agonist in HD mouse models
    Wenzhen Duan; Fiscal Year: 2012
    ..Our proposed studies will examine the effect of a clinical approved PPAR? agonist on disease onset and progression in mouse models of HD and result in a strategy to develop therapeutics for HD. ..
  58. miRNAs and PPAR-gamma-induced neuroprotection
    Raghu Vemuganti; Fiscal Year: 2013
    ..The overall goal is to study if PPAR? is in a cyclical loop with certain miRNA and their mutual inducibility has functional significance. ..
  59. S Russ Price; Fiscal Year: 2015
    ..Given the similarities of the wasting syndromes in a broad range of debilitating diseases (e.g., cancer, diabetes, heart disease), our findings may be widely applicable to many patients. ..
  60. Frank M Faraci; Fiscal Year: 2016
    ....
  61. Audrey S Dickey; Fiscal Year: 2014
    ..By elucidating the role of the PPAR [unreadable] signaling pathway in HD, targets for treatment may be found not only for HD, but other polyglutamine diseases and neurodegenerative diseases. ..
  62. Omer Yilmaz; Fiscal Year: 2014
    ....
  63. Deborah E Sullivan; Fiscal Year: 2014
    ....
  64. PPAR-gamma as a therapeutic target after TBI
    Raghu Vemuganti; Fiscal Year: 2010
    ..The ultimate goal is to identify drugs that benefit the recovery of brain trauma patients. ..
  65. PPARY ADIPOGENIC ACTION CONTROL BY COVALENT MODIFICATION
    Evan Rosen; Fiscal Year: 2001
    ..These studies will help us define how molecular events inside the adipocyte reflect upon the nutritional status of the whole organism. ..
  66. The Role of PPAR-gamma Expression on Insulin Action
    Andrea Hevener; Fiscal Year: 2006
    ..Despite the known actions of TZDs to improve insulin sensitivity, many aspects of PPARgamma biology remain unclear...
  67. MOLECULAR BASIS OF HIV LIPODYSTROPHY: ROLE OF VPR
    Ashok Balasubramanyam; Fiscal Year: 2003
    ....
  68. Chemoprevention of Pituitary Corticotroph Tumors
    Anthony Heaney; Fiscal Year: 2006
    ..Our ultimate goal is to develop a rationale for clinical application of these PPAR-gamma ligands as a novel medical therapy in Cushing's disease. ..