PP1

Summary

Gene Symbol: PP1
Description: protein phosphatase 1 catalytic subunit alpha
Alias: PP-1A, PP1A, PP1alpha, PPP1A, serine/threonine-protein phosphatase PP1-alpha catalytic subunit, protein phosphatase 1, catalytic subunit, alpha isoform, protein phosphatase 1, catalytic subunit, alpha isozyme, serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit, testicular tissue protein Li 155
Species: human

Top Publications

  1. ncbi Nuclear protein phosphatase-1 regulates HIV-1 transcription
    Tatyana Ammosova
    Center for Sickle Cell Disease and Department of Biochemistry and Molecular Biology, Howard University, Washington, D C 20059, USA
    J Biol Chem 278:32189-94. 2003
  2. ncbi The protein phosphatase-1 (PP1) regulator, nuclear inhibitor of PP1 (NIPP1), interacts with the polycomb group protein, embryonic ectoderm development (EED), and functions as a transcriptional repressor
    Qiming Jin
    Division of Biochemistry, Faculty of Medicine, University of Leuven, B 3000 Leuven, Belgium
    J Biol Chem 278:30677-85. 2003
  3. pmc Caveolin-1 maintains activated Akt in prostate cancer cells through scaffolding domain binding site interactions with and inhibition of serine/threonine protein phosphatases PP1 and PP2A
    Likun Li
    Scott Department of Urology, Baylor College of Medicine, 6560 Fannin, Suite 2100, Houston, TX 77030, USA
    Mol Cell Biol 23:9389-404. 2003
  4. ncbi Suppression of IP3-mediated calcium release and apoptosis by Bcl-2 involves the participation of protein phosphatase 1
    Liping Xu
    Department of Pathology, Wayne State University School of Medicine, 540 E Canfield, Detroit, MI 48201, USA
    Mol Cell Biochem 295:153-65. 2007
  5. doi Cell polarity-determining proteins Par-3 and PP-1 are involved in epithelial tight junction defects in coeliac disease
    Michael Schumann
    Department of Gastroenterology, Infectious Diseases and Rheumatology, Campus Benjamin Franklin, Charite Berlin, Berlin, Germany
    Gut 61:220-8. 2012
  6. doi Protein phosphatase 1-dependent dephosphorylation of Akt is the prime signaling event in sphingosine-induced apoptosis in Jurkat cells
    Faisal Thayyullathil
    Cell Signaling Laboratory, Department of Biochemistry, Faculty of Medicine and Health Sciences, UAE University P O Box 17666, Al Ain, UAE
    J Cell Biochem 112:1138-53. 2011
  7. ncbi Interaction of inhibitor-2 with the catalytic subunit of type 1 protein phosphatase. Identification of a sequence analogous to the consensus type 1 protein phosphatase-binding motif
    J Yang
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202 5122, USA
    J Biol Chem 275:22635-44. 2000
  8. pmc Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1
    J H Connor
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell Biol 21:6841-50. 2001
  9. doi CCDC6 represses CREB1 activity by recruiting histone deacetylase 1 and protein phosphatase 1
    V Leone
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia di Napoli, Universita degli Studi di Napoli Federico II, Naples, Italy
    Oncogene 29:4341-51. 2010
  10. ncbi Identification and characterization of a novel protein inhibitor of type 1 protein phosphatase
    H Shirato
    Division of Biochemical Oncology and Immunology, Institute for Genetic Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo 060 0815, Japan
    Biochemistry 39:13848-55. 2000

Research Grants

Scientific Experts

Detail Information

Publications120 found, 100 shown here

  1. ncbi Nuclear protein phosphatase-1 regulates HIV-1 transcription
    Tatyana Ammosova
    Center for Sickle Cell Disease and Department of Biochemistry and Molecular Biology, Howard University, Washington, D C 20059, USA
    J Biol Chem 278:32189-94. 2003
    We recently reported that protein phosphatase 1 (PP1) dephosphorylates RNA polymerase II C-terminal repeats and regulates HIV-1 transcription in vitro...
  2. ncbi The protein phosphatase-1 (PP1) regulator, nuclear inhibitor of PP1 (NIPP1), interacts with the polycomb group protein, embryonic ectoderm development (EED), and functions as a transcriptional repressor
    Qiming Jin
    Division of Biochemistry, Faculty of Medicine, University of Leuven, B 3000 Leuven, Belgium
    J Biol Chem 278:30677-85. 2003
    ..Nucleic acids also decreased the potency of NIPP1 as an inhibitor of PP1, but they did not prevent the formation of a ternary NIPP1.EED.PP1 complex...
  3. pmc Caveolin-1 maintains activated Akt in prostate cancer cells through scaffolding domain binding site interactions with and inhibition of serine/threonine protein phosphatases PP1 and PP2A
    Likun Li
    Scott Department of Urology, Baylor College of Medicine, 6560 Fannin, Suite 2100, Houston, TX 77030, USA
    Mol Cell Biol 23:9389-404. 2003
    ..We subsequently found that cav-1 interacts with and inhibits serine/threonine protein phosphatases PP1 and PP2A through scaffolding domain binding site interactions...
  4. ncbi Suppression of IP3-mediated calcium release and apoptosis by Bcl-2 involves the participation of protein phosphatase 1
    Liping Xu
    Department of Pathology, Wayne State University School of Medicine, 540 E Canfield, Detroit, MI 48201, USA
    Mol Cell Biochem 295:153-65. 2007
    ..suppresses the IP3-sensitive Ca2+ release in MCF-7 cells focusing on the possible role of protein phosphatase 1 (PP1)...
  5. doi Cell polarity-determining proteins Par-3 and PP-1 are involved in epithelial tight junction defects in coeliac disease
    Michael Schumann
    Department of Gastroenterology, Infectious Diseases and Rheumatology, Campus Benjamin Franklin, Charite Berlin, Berlin, Germany
    Gut 61:220-8. 2012
    ..Epithelial barrier defects are well known in coeliac disease, but the mechanisms are only poorly defined. It is unclear, whether barrier disturbance reflects upregulated epithelial transcytosis or paracellular leakage...
  6. doi Protein phosphatase 1-dependent dephosphorylation of Akt is the prime signaling event in sphingosine-induced apoptosis in Jurkat cells
    Faisal Thayyullathil
    Cell Signaling Laboratory, Department of Biochemistry, Faculty of Medicine and Health Sciences, UAE University P O Box 17666, Al Ain, UAE
    J Cell Biochem 112:1138-53. 2011
    ..A, phosphatidic acid, tautomycin, and okadaic acid) indicates an important role for protein phosphatase 1 (PP1) in this process...
  7. ncbi Interaction of inhibitor-2 with the catalytic subunit of type 1 protein phosphatase. Identification of a sequence analogous to the consensus type 1 protein phosphatase-binding motif
    J Yang
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202 5122, USA
    J Biol Chem 275:22635-44. 2000
    Inhibitor-2 (I-2) is the regulatory subunit of a cytosolic type 1 Ser/Thr protein phosphatase (PP1) and potently inhibits the activity of the free catalytic subunit (CS1)...
  8. pmc Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1
    J H Connor
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell Biol 21:6841-50. 2001
    ..inhibitor 1 (I-1), a protein kinase A (PKA)-activated inhibitor of type 1 protein serine/threonine phosphatase (PP1), in a yeast two-hybrid screen of a human brain cDNA library...
  9. doi CCDC6 represses CREB1 activity by recruiting histone deacetylase 1 and protein phosphatase 1
    V Leone
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia di Napoli, Universita degli Studi di Napoli Federico II, Naples, Italy
    Oncogene 29:4341-51. 2010
    ..Therefore, the repression of CREB1 activity by CCDC6 has a critical function in the development of human thyroid papillary carcinomas carrying RET/PTC1 activation...
  10. ncbi Identification and characterization of a novel protein inhibitor of type 1 protein phosphatase
    H Shirato
    Division of Biochemical Oncology and Immunology, Institute for Genetic Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo 060 0815, Japan
    Biochemistry 39:13848-55. 2000
    We have isolated human cDNA for a novel type 1 protein phosphatase (PP1) inhibitory protein, named inhibitor-4 (I-4), from a cDNA library of germ cell tumors...
  11. ncbi Bcl-2 targets protein phosphatase 1 alpha to Bad
    V Ayllon
    Department of Immunology and Oncology, Centro Nacional de Biotecnologia, Campus de Cantoblanco, Madrid, Spain
    J Immunol 166:7345-52. 2001
    ..We recently have described that PP1alpha is a Ras-activated Bad phosphatase that regulates IL-2 deprivation-induced apoptosis...
  12. ncbi The RNA-binding protein Staufen from rat brain interacts with protein phosphatase-1
    Michaela Monshausen
    Institute for Cell Biochemistry and Clinical Neurobiology, University of Hamburg, Germany
    J Neurochem 81:557-64. 2002
    ..Cellular functions of Staufen may be regulated via phosphorylation or Staufen may recruite the phosphatase into specific ribonucleoprotein complexes...
  13. ncbi PNUTS, a protein phosphatase 1 (PP1) nuclear targeting subunit. Characterization of its PP1- and RNA-binding domains and regulation by phosphorylation
    Young Mi Kim
    Department of Biochemistry, College of Natural Sciences, Kangwon National University, Chunchon, Kangwon Do 200 701, Korea
    J Biol Chem 278:13819-28. 2003
    PNUTS, Phosphatase 1 NUclear Targeting Subunit, is a recently described protein that targets protein phosphatase 1 (PP1) to the nucleus. In the present study, we characterized the biochemical properties of PNUTS...
  14. doi Protein phosphatase 1 (PP-1)-dependent inhibition of insulin secretion by leptin in INS-1 pancreatic β-cells and human pancreatic islets
    Peter Kuehnen
    Institute of Experimental Pediatric Endocrinology, Charite Children s Hospital, Universitatsmedizin Berlin, Berlin, Germany
    Endocrinology 152:1800-8. 2011
    ....
  15. ncbi Dynamic targeting of protein phosphatase 1 within the nuclei of living mammalian cells
    L Trinkle-Mulcahy
    MSI WTB complex, University of Dundee, Dundee DD1 5EH, Scotland
    J Cell Sci 114:4219-28. 2001
    ..b>PP1alpha and PP1gamma fluorescent protein fusions show largely complimentary localization patterns, particularly within ..
  16. ncbi DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1
    H C Hemmings
    Nature 310:503-5. 1984
    ..Thus, the basal ganglia of mammalian brain contain a region-specific neuronal phosphoprotein that is a protein phosphatase inhibitor...
  17. ncbi Identification and characterization of the human HCG V gene product as a novel inhibitor of protein phosphatase-1
    J Zhang
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla 10595, USA
    Biochemistry 37:16728-34. 1998
    The catalytic subunit of mammalian protein phosphatase-1 (PP1) is known to bind to a number of regulatory subunits, whose functions include the targeting of the catalytic subunit to the molecular proximity of its substrate proteins...
  18. pmc Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complex
    P M Ajuh
    Department of Biochemistry, The University of Dundee, MSI WTB complex, Dow Street, Dundee DD1 5EH, UK
    Nucleic Acids Res 28:678-86. 2000
    We have screened a human cDNA expression library with a digoxygenin-labelled protein phosphatase 1 (PP1) probe to identify novel PP1 interacting proteins...
  19. pmc NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1
    N R Helps
    Medical Research Council Protein Phosphorylation Unit, Department of Biochemistry, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
    Biochem J 349:509-18. 2000
    ..a predominant localization at centrosomes, is identified as a protein which interacts with protein phosphatase 1 (PP1) using the yeast two-hybrid system...
  20. pmc Targeting protein phosphatase 1 (PP1) to the actin cytoskeleton: the neurabin I/PP1 complex regulates cell morphology
    Carey J Oliver
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell Biol 22:4690-701. 2002
    Neurabin I, a neuronal actin-binding protein, binds protein phosphatase 1 (PP1) and p70 ribosomal S6 protein kinase (p70S6K), both proteins implicated in cytoskeletal dynamics...
  21. ncbi Inhibitor-2 regulates protein phosphatase-1 complexed with NimA-related kinase to induce centrosome separation
    Masumi Eto
    Center for Cell Signaling, University of Virginia School of Medicine, Charlottesville 22908, USA
    J Biol Chem 277:44013-20. 2002
    ..PP1C complex. Thus, Inh2 can enhance the kinase activity of the Nek2.PP1C complex via inhibition of phosphatase activity to initiate centrosome separation...
  22. ncbi Initiation factor 2B activity is regulated by protein phosphatase 1, which is activated by the mitogen-activated protein kinase-dependent pathway in insulin-like growth factor 1-stimulated neuronal cells
    Celia Quevedo
    Servicio de Bioquímica Investigación, Hospital Ramon y Cajal, 28034 Madrid, Spain
    J Biol Chem 278:16579-86. 2003
    ..with ERK1 and -2, and the association of ERK with PP1C was stimulated by IGF1 treatment, resulting in increased PP1 activity...
  23. ncbi Scapinin, a putative protein phosphatase-1 regulatory subunit associated with the nuclear nonchromatin structure
    Junji Sagara
    Department of Molecular Oncology, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    J Biol Chem 278:45611-9. 2003
    ..A yeast two-hybrid assay revealed that this protein bound to the catalytic subunit of protein phosphatase-1 (PP1). Furthermore, it inhibited PP1 activity in vitro...
  24. pmc Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteins
    Patrick B Allen
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA
    Proc Natl Acad Sci U S A 101:7187-92. 2004
    Protein phosphatase 1 (PP1) is a multifunctional enzyme with diverse roles in the nervous system, including regulation of synaptic activity and dendritic morphology...
  25. ncbi Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK
    Kazuyuki Kitatani
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 281:36793-802. 2006
    ..serine/threonine protein phosphatases was performed, and it was observed that knock-down of protein phosphatase 1 (PP1) catalytic subunits significantly increased p38 phosphorylation, suggesting activation of PP1 results in an ..
  26. ncbi Regulation of HIV-1 transcription by protein phosphatase 1
    Sergei Nekhai
    Center for Sickle Cell Disease, Howard University, Washington, DC 20059, USA
    Curr HIV Res 5:3-9. 2007
    ..Our recent studies identified protein phosphatase-1 (PP1) as an important regulator of HIV-1 transcription...
  27. pmc Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex
    Wen Luo
    Department of Oncological Sciences, University of Utah, Salt Lake City, UT 84112 5550, USA
    EMBO J 26:1511-21. 2007
    ..Using a directed RNAi screen we find that protein phosphatase 1 (PP1), a ubiquitous serine/threonine phosphatase, is a novel potent positive physiologic regulator of the Wnt/beta-..
  28. ncbi Proteomic characterization of protein phosphatase 1 complexes in ischemia-reperfusion and ischemic tolerance
    Cristina Cid
    Department of Investigation, Hospital Ramon y Cajal, Madrid, Spain
    Proteomics 7:3207-18. 2007
    ..b>PP1alpha and PP1gamma were immunoprecipitated and resolved by 2-D...
  29. ncbi Phosphorylation of protein phosphatase 1 by cyclin-dependent protein kinase 5 during nerve growth factor-induced PC12 cell differentiation
    Tong Li
    Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Canada
    J Biol Chem 282:6619-28. 2007
    ..In this study, we observed that phosphorylation of protein phosphatase 1 (PP1) on Thr(320) is reduced in brain extracts from Egr-1(-/-) mice, indicating that a kinase downstream of Egr-1 ..
  30. ncbi The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit
    T Durfee
    Center for Molecular Medicine Institute of Biotechnology, University of Texas Health Science Center, San Antonio 78245
    Genes Dev 7:555-69. 1993
    ..Cell cycle synchrony experiments revealed that this association occurs from mitosis to early G1. The implications of these findings on the regulation of both proteins are discussed...
  31. ncbi Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1
    L C Hsieh-Wilson
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York 10021, USA
    Biochemistry 38:4365-73. 1999
    Protein phosphatase-1 (PP1) plays an important role in a variety of cellular processes, including muscle contraction, cell-cycle progression, and neurotransmission...
  32. ncbi Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220
    R V Schillace
    Howard Hughes Medical Institute, L 474 Vollum Institute, Oregon Health Sciences University, 3181 S W Sam Jackson Park Road, Portland, Oregon 97201 3098, USA
    Curr Biol 9:321-4. 1999
    The cyclic AMP (cAMP)-dependent protein kinase (PKA) and the type 1 protein phosphatase (PP1) are broad-specificity signaling enzymes with opposing actions that catalyze changes in the phosphorylation state of cellular proteins...
  33. ncbi Characterization of a novel giant scaffolding protein, CG-NAP, that anchors multiple signaling enzymes to centrosome and the golgi apparatus
    M Takahashi
    Department of Biology, Faculty of Science, Kobe University, Kobe 657 8501, Japan
    J Biol Chem 274:17267-74. 1999
    ....
  34. ncbi NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry
    A Boudrez
    Afdeling Biochemie and Center for Human Genetics VIB, Faculteit Geneeskunde, Katholieke Universiteit Leuven, Belgium
    J Biol Chem 275:25411-7. 2000
    NIPP1 is a regulatory subunit of a species of protein phosphatase-1 (PP1) that co-localizes with splicing factors in nuclear speckles...
  35. pmc Recruitment of protein phosphatase 1 to the nuclear envelope by A-kinase anchoring protein AKAP149 is a prerequisite for nuclear lamina assembly
    R L Steen
    Institute of Medical Biochemistry, University of Oslo, 0317 Oslo, Norway
    J Cell Biol 150:1251-62. 2000
    Subcellular targeting of cAMP-dependent protein kinase (protein kinase A [PKA]) and of type 1 protein phosphatase (PP1) is believed to enhance the specificity of these enzymes...
  36. ncbi Protein phosphatase 1--targeted in many directions
    Patricia T W Cohen
    Medical Research Council Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD15EH, Scotland, UK
    J Cell Sci 115:241-56. 2002
    Protein phosphatase 1 (PP1) is a major eukaryotic protein serine/threonine phosphatase that regulates an enormous variety of cellular functions through the interaction of its catalytic subunit (PP1c) with over fifty different established ..
  37. ncbi A protein phosphatase from human T cells augments tat transactivation of the human immunodeficiency virus type 1 long-terminal repeat
    Diana C Bharucha
    Department of Biochemistry and Molecular Biology, The George Washington University Medical Center, Washington, DC 20037, USA
    Virology 296:6-16. 2002
    ..The Tat-associated protein phosphatase (TAPP) is related to the serine/threonine, type 1, protein phosphatase (PP1) family...
  38. pmc Phosphorylation of the RNA polymerase II carboxyl-terminal domain by CDK9 is directly responsible for human immunodeficiency virus type 1 Tat-activated transcriptional elongation
    Young Kyeung Kim
    Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 2QH, United Kingdom
    Mol Cell Biol 22:4622-37. 2002
    ..We conclude that phosphorylation of the RNA polymerase II CTD by CDK9 enhances transcription elongation directly...
  39. ncbi The anti-apoptotic molecules Bcl-xL and Bcl-w target protein phosphatase 1alpha to Bad
    Veronica Ayllon
    Centro Nacional de Biotenología, Department of Immunology and Oncology, Campus de Cantoblanco, UAM, Madrid, Spain
    Eur J Immunol 32:1847-55. 2002
    Bcl-xL and Bcl-w specifically interact with PP1alpha and Bad. A phosphatase activity sensitive to okadaic acid was detected in Bcl-xL, Bcl-w and Bad immunoprecipitates...
  40. ncbi Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1
    Hugo Ceulemans
    Afdeling Biochemie, Faculteit Geneeskunde, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    J Biol Chem 277:47331-7. 2002
    Functional studies of the protein phosphatase-1 (PP1) regulator Sds22 suggest that it is indirectly and/or directly involved in one of the most ancient functions of PP1, i.e...
  41. pmc Dephosphorylation of CDK9 by protein phosphatase 2A and protein phosphatase-1 in Tat-activated HIV-1 transcription
    Tatyana Ammosova
    Center for Sickle Cell Disease, Howard University, 2121 Georgia Ave, N W Washington, DC 20059, USA
    Retrovirology 2:47. 2005
    ..In the present study we analyze relative contribution of PP2A and PP1 to dephosphorylation of CDK9 and to HIV-1 transcription in vitro and in vivo.
  42. ncbi Nuclear targeting of protein phosphatase-1 by HIV-1 Tat protein
    Tatyana Ammosova
    Center for Sickle Cell Disease, Howard University, Washington, DC 20059, USA
    J Biol Chem 280:36364-71. 2005
    ..We previously showed that Tat-induced HIV-1 transcription is regulated by protein phosphatase-1 (PP1)...
  43. pmc The interaction of PP1 with BRCA1 and analysis of their expression in breast tumors
    Sherry L Winter
    Fred A, Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    BMC Cancer 7:85. 2007
    ..Additionally, detection of changes in the expression levels of BRCA1 and its interacting proteins in primary human breast tumors may further illuminate their role in the development of breast cancer...
  44. ncbi A complex of catalytically inactive protein phosphatase-1 sandwiched between Sds22 and inhibitor-3
    Bart Lesage
    Laboratory of Biosignaling and Therapeutics, Department of Molecular Cell Biology, Faculty of Medicine, Catholic University of Leuven, B 3000 Leuven, Belgium
    Biochemistry 46:8909-19. 2007
    Protein Ser/Thr phosphatase-1 (PP1) associates with a host of proteins to form substrate-specific holoenzymes. Sds22 and Inhibitor-3 (I3) are two independently described ancient interactors of PP1...
  45. ncbi A novel Akt/PKB-interacting protein promotes cell adhesion and inhibits familial amyotrophic lateral sclerosis-linked mutant SOD1-induced neuronal death via inhibition of PP2A-mediated dephosphorylation of Akt/PKB
    Mikiro Nawa
    Department of Anatomy, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Cell Signal 20:493-505. 2008
    ..Given its ubiquitous expression, BTBD10 appears to behave as a suppressor of cell death including neuronal cell death related to ALS and an enhancer of cell growth via its positive regulation of Akt phosphorylation...
  46. pmc PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling
    Ruichuan Chen
    Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, Fujian, China
    Genes Dev 22:1356-68. 2008
    ..alone is insufficient, and PP2B must act sequentially and cooperatively with protein phosphatase 1alpha (PP1alpha) to disrupt 7SK snRNP...
  47. pmc Phosphatase inhibitor-2 balances protein phosphatase 1 and aurora B kinase for chromosome segregation and cytokinesis in human retinal epithelial cells
    Weiping Wang
    Center for Cell Signaling, Departments of Microbiology and Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Mol Biol Cell 19:4852-62. 2008
    ..These defects did not involve changes in levels of protein phosphatase-1 (PP1), and the multinuclear phenotype was rescued by overexpression of I-2...
  48. doi Nuclear inhibitor of protein phosphatase-1 (NIPP1) directs protein phosphatase-1 (PP1) to dephosphorylate the U2 small nuclear ribonucleoprotein particle (snRNP) component, spliceosome-associated protein 155 (Sap155)
    Nobuhiro Tanuma
    Division of Cancer Chemotherapy, Miyagi Cancer Center Research Institute, Natori 981 1293, Japan
    J Biol Chem 283:35805-14. 2008
    ..Recent work has revealed essential roles for Ser/Thr phosphatases, such as protein phosphatase-1 (PP1), in splicing, but how these phosphatases are regulated is largely unknown...
  49. pmc Crystal structures of protein phosphatase-1 bound to nodularin-R and tautomycin: a novel scaffold for structure-based drug design of serine/threonine phosphatase inhibitors
    Matthew S Kelker
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, RI 02903, USA
    J Mol Biol 385:11-21. 2009
    ..Many naturally occurring, molecular toxins modulate PP1 activity, though the exact mechanism of this differential regulation is not understood...
  50. pmc Spinophilin directs protein phosphatase 1 specificity by blocking substrate binding sites
    Michael J Ragusa
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, Rhode Island, USA
    Nat Struct Mol Biol 17:459-64. 2010
    The serine/threonine protein phosphatase 1 (PP1) dephosphorylates hundreds of key biological targets. PP1 associates with >or=200 regulatory proteins to form highly specific holoenzymes...
  51. pmc The phosphatase interactor NIPP1 regulates the occupancy of the histone methyltransferase EZH2 at Polycomb targets
    Nele Van Dessel
    Laboratory of Biosignaling and Therapeutics, Department of Molecular Cell Biology, Faculty of Medicine, KULeuven, B 3000 Leuven, Belgium
    Nucleic Acids Res 38:7500-12. 2010
    ..Here, we show that NIPP1, a regulator of protein Ser/Thr phosphatase-1 (PP1), forms a complex with PP1 and PRC2 components on chromatin...
  52. pmc Mass spectrometry and biochemical analysis of RNA polymerase II: targeting by protein phosphatase-1
    Marina Jerebtsova
    Center for Molecular Physiology, Children s National Medical Center, Washington, DC, USA
    Mol Cell Biochem 347:79-87. 2011
    ..We previously reported that protein phosphatase-1 (PP1) dephosphorylates RNAPII CTD in vitro and inhibition of nuclear PP1-blocked viral transcription...
  53. pmc PP1 cooperates with ASPP2 to dephosphorylate and activate TAZ
    Chen Ying Liu
    Key Laboratory of Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology School of Medicine, Lab, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China
    J Biol Chem 286:5558-66. 2011
    ..Here, we identified PP1 as a bona fide TAZ phosphatase. PP1A dephosphorylates TAZ at Ser-89 and Ser-311, promotes TAZ nuclear translocation, and stabilizes TAZ by disrupting ..
  54. pmc Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock
    Isabelle Schmutz
    Department of Biology, Unit of Biochemistry, University of Fribourg, Fribourg, Switzerland
    PLoS ONE 6:e21325. 2011
    ..Here, we identify protein phosphatase 1 (PP1) as regulator of period and light-induced resetting of the mammalian circadian clock...
  55. ncbi Cloning and characterization of a human protein phosphatase 1-encoding cDNA
    Q Song
    Queensland Cancer Fund Research Unit, Queensland Institute of Medical Research, Bancroft Centre, Brisbane, Australia
    Gene 129:291-5. 1993
    While sequence information is available for a number of eukaryotic protein phosphatase 1 (PP1)-encoding genes, the cloning and characterization of a complete human pp1 gene has not been reported...
  56. ncbi Platelet adhesion to collagen under flow causes dissociation of a phosphoprotein complex of heat-shock proteins and protein phosphatase 1
    R Polanowska-Grabowska
    Department of Biochemistry, University of Virginia, Charlottesville 22908, USA
    Blood 90:1516-26. 1997
    ..In addition, treatment with okadaic acid (OA), an inhibitor of serine/threonine protein phosphatases type 1 (PP1) and 2A (PP2A), caused significant inhibition of adhesion, suggesting that adhesion is regulated by OA-sensitive ..
  57. ncbi Association of brain protein phosphatase 1 with cytoskeletal targeting/regulatory subunits
    R J Colbran
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, U S A
    J Neurochem 69:920-9. 1997
    ..Size-exclusion chromatography of solubilized extracts separated two main PP1 activities (approximately 600 and approximately 100 kDa)...
  58. ncbi A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2
    Hong Wang
    Center for Cell Signaling, University of Virginia School of Medicine, Charlottesville, VA 22908 0577, USA
    J Biol Chem 277:49605-12. 2002
    ..Inh2 associated with KPI-2 C-terminal domain with and without PP1C. Thus, KPI-2 is a kinase with sites to associate with PP1C and Inh2 to form a regulatory complex that is localized to membranes...
  59. ncbi Regulation of BRCA1 phosphorylation by interaction with protein phosphatase 1alpha
    Ying Liu
    Department of Oncological Sciences, University of Utah, Salt Lake City, Utah 84112, USA
    Cancer Res 62:6357-61. 2002
    ..Data presented here show that both recombinant protein phosphatase 1 alpha (PP1alpha) catalytic subunit and endogenous PP1alpha dephosphorylate GST-BF4-P. Inhibitor 2 abolishes this activity...
  60. pmc Human BAG-1 proteins bind to the cellular stress response protein GADD34 and interfere with GADD34 functions
    Wesley J Hung
    Division of Medical Oncology, Department of Medicine, Veterans Administration Puget Sound Health Care System, Seattle Division, 1660 S Columbian Way, Seattle, WA 98108, USA
    Mol Cell Biol 23:3477-86. 2003
    ..GADD34 binds to protein phosphatase PP1 and can attenuate the translational elongation of key transcriptional factors through dephosphorylation of ..
  61. ncbi Isolation and characterization of PNUTS, a putative protein phosphatase 1 nuclear targeting subunit
    P B Allen
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021, USA
    J Biol Chem 273:4089-95. 1998
    Protein phosphatase 1 (PP1) is found in the cell nucleus and has been implicated in several aspects of nuclear function...
  62. doi ADAM28: a potential oncogene involved in asbestos-related lung adenocarcinomas
    Casey M Wright
    School of Medicine, The University of Queensland, QLD, Australia
    Genes Chromosomes Cancer 49:688-98. 2010
    ....
  63. pmc Expression analysis of imbalanced genes in prostate carcinoma using tissue microarrays
    I Prowatke
    Division of Molecular Genetics, German Cancer Research Center, Heidelberg, Germany
    Br J Cancer 96:82-8. 2007
    ..FASN), MYC, beta-adrenergic receptor kinase 1 (BARK1, GRK2) the catalytic subunits of protein phosphatases PP1alpha (PPP1CA) and PP2A (PPP2CB) and metastasis suppressor NM23-H1...
  64. pmc Prediction and diagnosis of bladder cancer recurrence based on urinary content of hTERT, SENP1, PPP1CA, and MCM5 transcripts
    Anne Sofie Brems-Eskildsen
    Department of Molecular Medicine, Aarhus University Hospital, Skejby, Denmark
    BMC Cancer 10:646. 2010
    ..Our objective was to determine the usability of urine content of mRNA in the detection and prediction of bladder cancer recurrence...
  65. ncbi Protein kinase C is regulated in vivo by three functionally distinct phosphorylations
    L M Keranen
    Department of Pharmacology, University of California at San Diego, La Jolla 92093 0640, USA
    Curr Biol 5:1394-1403. 1995
    ..Here, we show that protein kinase C must first be processed by three distinct phosphorylations before it is competent to respond to second messengers...
  66. pmc Androgen receptor phosphorylation and activity are regulated by an association with protein phosphatase 1
    Shaoyong Chen
    Cancer Biology Program, Hematology Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 284:25576-84. 2009
    ..More specific inhibitors of PP2A (fostriecin) and PP1 (tautomycin and siRNA against the PP1alpha catalytic subunit) demonstrated that PP1 and protein phosphatase 2A had opposite effects on AR protein and ..
  67. pmc Protein phosphatase 1α mediates ceramide-induced ERM protein dephosphorylation: a novel mechanism independent of phosphatidylinositol 4, 5-biphosphate (PIP2) and myosin/ERM phosphatase
    Daniel Canals
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 287:10145-55. 2012
    ..However, the results show that ERM dephosphorylation was blocked by treatment with protein phosphatase 1 (PP1) pharmacological inhibitors and specifically by siRNA to PP1α, whereas okadaic acid, a PP2A inhibitor, failed...
  68. pmc Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle
    Evy Lobbestael
    Laboratory for Neurobiology and Gene Therapy, Department of Neurosciences, KU Leuven, Kapucijnenvoer 33, 3000 Leuven, Belgium
    Biochem J 456:119-28. 2013
    ..Therefore we aimed to identify the phosphatase for LRRK2. Using a panel of recombinant phosphatases, we found that PP1 (protein phosphatase 1) efficiently dephosphorylates LRRK2 in vitro...
  69. doi A cell-based screening for TAZ activators identifies ethacridine, a widely used antiseptic and abortifacient, as a compound that promotes dephosphorylation of TAZ and inhibits adipogenesis in C3H10T1/2 cells
    Shodai Kawano
    Department of Medical Biochemistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    J Biochem 158:413-23. 2015
    ..Ethacridine inhibits adipogenesis in mesenchymal C3H10T1/2 cells through the activation of TAZ. This finding suggests that ethacridine is a bona fide TAZ activator and supports that our assay is useful to discover TAZ activators. ..
  70. pmc Characterization of the interaction between DARPP-32 and protein phosphatase 1 (PP-1): DARPP-32 peptides antagonize the interaction of PP-1 with binding proteins
    Y G Kwon
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 94:3536-41. 1997
    ....
  71. ncbi BH-protocadherin-c, a member of the cadherin superfamily, interacts with protein phosphatase 1 alpha through its intracellular domain
    K Yoshida
    Department of Virology, Institute of Medical Science, The University of Tokyo, Japan
    FEBS Lett 460:93-8. 1999
    ..One clone encoded protein phosphatase type I isoform alpha (PP1alpha) and another two PP1alpha2...
  72. ncbi PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts
    S O Marx
    Center for Molecular Cardiology, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Cell 101:365-76. 2000
    ..6, PKA, the protein phosphatases PP1 and PP2A, and an anchoring protein, mAKAP...
  73. ncbi Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle
    H Katayama
    Division of Pathology and Laboratory Medicine, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 276:46219-24. 2001
    ..We report that STK15 contains two functional binding sites for protein phosphatase type 1 (PP1), and the binding of these proteins is cell cycle-regulated peaking at mitosis...
  74. pmc Type 1 phosphatase, a negative regulator of cardiac function
    Andrew N Carr
    Department of Pharmacology and Cell Biophysics, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Mol Cell Biol 22:4124-35. 2002
    Increases in type 1 phosphatase (PP1) activity have been observed in end stage human heart failure, but the role of this enzyme in cardiac function is unknown...
  75. ncbi The direct binding of the catalytic subunit of protein phosphatase 1 to the PKR protein kinase is necessary but not sufficient for inactivation and disruption of enzyme dimer formation
    Seng Lai Tan
    Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, 98195, USA
    J Biol Chem 277:36109-17. 2002
    ..of counteracting the PKR-mediated growth defect in yeast led to the identification of the catalytic subunit (PP1(C)) of protein phosphatase 1alpha...
  76. ncbi Protein Phosphatase 1 binds strongly to the retinoblastoma protein but not to p107 or p130 in vitro and in vivo
    Joshua L Dunaief
    FM Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Curr Eye Res 24:392-6. 2002
    ..To identify and characterize retinoblastoma protein (pRb) binding proteins that may influence retinoblast proliferation and retinal pigment epithelial cell survival...
  77. ncbi Analysis of isoform specific function of PP1 catalytic subunits in mammalian cells using siRNA
    Tadashi Okada
    Division of Biochemical Oncology and Immunology, Institute for Genetic Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo 060 0815, Japan
    Int J Oncol 25:1383-8. 2004
    Protein phosphatase type 1 (PP1) is involved in the regulation of numerous cell functions in mammalian cells...
  78. ncbi Histone acetylation-independent effect of histone deacetylase inhibitors on Akt through the reshuffling of protein phosphatase 1 complexes
    Chang Shi Chen
    Division of Medicinal Chemistry, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 280:38879-87. 2005
    ..dephosphorylation in U87MG glioblastoma and PC-3 prostate cancer cells by disrupting HDAC-protein phosphatase 1 (PP1) complexes...
  79. ncbi Downregulation of Fer induces PP1 activation and cell-cycle arrest in malignant cells
    O Pasder
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    Oncogene 25:4194-206. 2006
    ..1 (PP1) binding motifs in the kinase domain of Fer and the association of Fer with the pRB phosphatase PP1alpha was verified using co-immunoprecipitation analysis...
  80. doi Deactivation of the kinase IKK by CUEDC2 through recruitment of the phosphatase PP1
    Hui Yan Li
    State Key Laboratory of Proteomics, Institute of Basic Medical Sciences, National Center of Biomedical Analysis, Beijing 100850, China
    Nat Immunol 9:533-41. 2008
    ..Notably, CUEDC2 also interacted with GADD34, a regulatory subunit of protein phosphatase 1 (PP1)...
  81. pmc Tensin1 requires protein phosphatase-1alpha in addition to RhoGAP DLC-1 to control cell polarization, migration, and invasion
    Emily H Hall
    Center for Cell Signaling and Department of Microbiology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    J Biol Chem 284:34713-22. 2009
    ..The N-terminal domain of tensin1 associates with protein phosphatase-1alpha (PP1alpha) and mediates PP1alpha localization to adhesions...
  82. doi Protein phosphatase-1 regulates Akt1 signal transduction pathway to control gene expression, cell survival and differentiation
    L Xiao
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, 68198 5870, USA
    Cell Death Differ 17:1448-62. 2010
    ..These results show that PP-1 acts as a major phosphatase to dephosphorylate AKT at Thr-450 and thus modulate its functions...
  83. pmc SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1
    Xu Li
    Department of Molecular Pharmacology, City of Hope Beckman Research Institute, Duarte, CA 91010, USA
    Sci Signal 3:ra32. 2010
    ..Here, we found that, whereas the protein phosphatase 1alpha isoform (PP1alpha) directly interacted with KAP1 under basal conditions, PP1beta interacted with KAP1 only in response to genotoxic ..
  84. pmc Association with endoplasmic reticulum promotes proteasomal degradation of GADD34 protein
    Wei Zhou
    Signature Research Program in Cardiovascular and Metabolic Disorders, Duke NUS Graduate Medical School, Singapore 169857
    J Biol Chem 286:21687-96. 2011
    ..Both WT GADD34 and the mutant, V25R, effectively scaffolded the α-isoform of protein phosphatase-1 (PP1α) and enabled eIF2α dephosphorylation...
  85. doi Consensus PP1 binding motifs regulate transcriptional corepression and alternative RNA splicing activities of the steroid receptor coregulators, p54nrb and PSF
    Liangliang Liu
    Vancouver Prostate Center, Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada
    Mol Endocrinol 25:1197-210. 2011
    ..Both p54nrb and PSF contain protein phosphatase 1 (PP1) consensus binding RVxF motifs, suggesting that PP1 may regulate phosphorylation status of p54nrb and PSF and thus ..
  86. doi Down-regulation of spinophilin in lung tumours contributes to tumourigenesis
    Sonia Molina-Pinelo
    Instituto de Biomedicina de Sevilla, IBIS HUVR Sevilla, Spain
    J Pathol 225:73-82. 2011
    The scaffold protein spinophilin (Spn, PPP1R9B) is one of the regulatory subunits of phosphatase-1a (PP1), targeting it to distinct subcellular locations and to its target...
  87. pmc Inhibitory member of the apoptosis-stimulating proteins of the p53 family (iASPP) interacts with protein phosphatase 1 via a noncanonical binding motif
    Susana Llanos
    Ludwig Institute for Cancer Research Ltd, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7DQ, United Kingdom
    J Biol Chem 286:43039-44. 2011
    ..Here, we show that all apoptosis-stimulating proteins of p53 (ASPP) family members can bind protein phosphatase 1 (PP1) via two distinct interacting motifs...
  88. pmc Sds22 and Repo-Man stabilize chromosome segregation by counteracting Aurora B on anaphase kinetochores
    Claudia Wurzenberger
    Institute of Biochemistry, Swiss Federal Institute of Technology Zurich, CH 8093 Zurich, Switzerland
    J Cell Biol 198:173-83. 2012
    ..By ribonucleic acid interference screening using a phosphorylation biosensor, we identified two PP1-targeting subunits, Sds22 and Repo-Man, which counteracted Aurora B-dependent phosphorylation of the outer ..
  89. pmc A role for PP1/NIPP1 in steering migration of human cancer cells
    Cristina Martin-Granados
    Institute of Medical Sciences, University of Aberdeen, Aberdeen, Scotland, United Kingdom
    PLoS ONE 7:e40769. 2012
    ..Notably, genetic disruption of protein serine/threonine phosphatase-1 (PP1) and its regulator NIPP1 decrease directional migration in these cell lines...
  90. pmc The molecular basis for substrate specificity of the nuclear NIPP1:PP1 holoenzyme
    Nichole O'Connell
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, RI 02912, USA
    Structure 20:1746-56. 2012
    Regulation of protein phosphatase 1 (PP1) is controlled by a diverse array of regulatory proteins. However, how these proteins direct PP1 specificity is not well understood...
  91. pmc Protein phosphatase 1alpha is a Ras-activated Bad phosphatase that regulates interleukin-2 deprivation-induced apoptosis
    V Ayllon
    Centro Nacional de Biotecnologia, Department of Immunology and Oncology, Campus de Cantoblanco, UAM, E 28049 Madrid, Spain
    EMBO J 19:2237-46. 2000
    ..proteins and co-immunoprecipitation techniques, we found that Bad interacts with protein phosphatase 1alpha (PP1alpha)...
  92. ncbi Dephosphorylation of PKCdelta by protein phosphatase 2Ac and its inhibition by nucleotides
    Jyoti Srivastava
    Protein Phosphorylation Laboratory, Cancer Research UK London Research Institute, Lincoln s Inn Fields Laboratories, 44 Lincoln s Inn Fields, WC2A 3PX, London, UK
    FEBS Lett 516:265-9. 2002
    The protein phosphatases PP1(c), PP2A(c) and PP2Calpha are shown to dephosphorylate protein kinase Cdelta (PKCdelta) in vitro; of these PP2A(c) displayed the highest specific activity towards PKCdelta...
  93. ncbi The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity
    Daniel Y Wu
    Division of Medical Oncology, Department of Medicine, Veterans Administration Puget Sound Health Care System, Seattle Division, Seattle, Washington 98108, USA
    J Biol Chem 277:27706-15. 2002
    ..GADD34 binds to protein phosphatase-1 (PP1) and can attenuate translational elongation of key transcriptional factors through dephosphorylation of eukaryotic ..
  94. ncbi A vitamin D receptor-Ser/Thr phosphatase-p70 S6 kinase complex and modulation of its enzymatic activities by the ligand
    David J Bettoun
    Gene Regulation, Bone, and Inflammation Research, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Biol Chem 277:24847-50. 2002
    ..Since p70(S6k) is essential for G(1)-S transition, our results provide a molecular basis of 1alpha,25-dihydroxyvitamin D(3)-induced G(1) block in colon cancer cells...
  95. ncbi A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta
    Chie Tanji
    Department of Biochemistry, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3, Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    J Biol Chem 277:36955-61. 2002
    ..Cyclic AMP-dependent protein kinase (PKA) and type 1 protein phosphatase (PP1) were also detected in this complex, suggesting that AKAP220, GSK-3beta, PKA, and PP1 form a quaternary complex...
  96. pmc Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution
    Jin Zhou
    Department of Pathology, University of California at San Diego, La Jolla, CA 92093, U S A
    Biochem J 369:387-98. 2003
    ..Whereas both isoforms bound polyoma virus middle tumour antigen equally well, only Aalpha bound SV40 small tumour antigen...
  97. ncbi N-CoR controls differentiation of neural stem cells into astrocytes
    Ola Hermanson
    Howard Hughes Medical Institute, Department of Molecular Medicine, University of California, San Diego, School of Medicine, 9500 Gilman Drive, Room 345, La Jolla, California 92093 0648, USA
    Nature 419:934-9. 2002
    ..We propose that repression by N-CoR, modulated by opposing enzymatic activities, is a critical mechanism in neural stem cells that underlies the inhibition of glial differentiation...
  98. pmc Inducible expression of catalytically active type 1 serine/threonine protein phosphatase in a human carcinoma cell line
    Jay E Reeder
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, New York, 14642, USA
    Cancer Cell Int 3:12. 2003
    ..a cell line for inducing protein expression of the type 1, alpha-isotype, serine/threonine protein phosphatase (PP1alpha)...
  99. ncbi Dephosphorylation of histone gamma-H2AX during repair of DNA double-strand breaks in mammalian cells and its inhibition by calyculin A
    I B Nazarov
    Department of Biological Chemistry, University of California Davis School of Medicine, Davis, California 95616, USA
    Radiat Res 160:309-17. 2003
    ..Our results confirm the tight association between DSBs and gamma-H2AX and the coupling of its in situ dephosphorylation to DSB repair...
  100. ncbi BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis
    Nika N Danial
    Howard Hughes Medical Institute, Dana Faber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 424:952-6. 2003
    ..BAD resides in a functional holoenzyme complex together with protein kinase A and protein phosphatase 1 (PP1) catalytic units, Wiskott-Aldrich family member WAVE-1 as an A kinase anchoring protein, and glucokinase (..
  101. ncbi Protein phosphatase 1alpha activity prevents oncogenic transformation
    Cathy W Y Liu
    Division of Hematology Oncology, Childrens Hospital Los Angeles, The University of Southern California Keck School of Medicine, Los Angeles, 90027, USA
    Mol Carcinog 45:648-56. 2006
    Cyclin-dependent kinase 2 (Cdk2) phosphorylates Thr320 of protein phosphatase 1alpha (PP1alpha) in late G(1), thereby inhibiting its activity...

Research Grants4

  1. mIgM and mIgD Receptor Signaling in B Lymphoma Apoptosis
    Gregory Carey; Fiscal Year: 2006
    ..Together, these studies will delineate proteins and signaling events, modules and programs initiated by the surface IgM or surface IgD receptors to effect survival, growth arrest and/or apoptosis in B-lymphoma cells. ..
  2. Regulation of BRCA1 Function by Protein Phosphatase 1
    Lih Ching Hsu; Fiscal Year: 2009
    ..BRCA1 in mitotic cells is mostly hypophosphorylated. We have demonstrated that protein phosphatase 1 alpha (PP1 alpha) interacts with BRCA1 and dephosphorylates BRCA1 phosphorylated by hCds1...
  3. Pathways of Therapy-induced Senescence in Cancer
    Daniel Y Wu; Fiscal Year: 2010
    ..These studies should yield the clinical relevance, novel markers and new mechanistic insights of accelerated cellular senescence in human cancers. ..