PNPLA3

Summary

Gene Symbol: PNPLA3
Description: patatin like phospholipase domain containing 3
Alias: ADPN, C22orf20, iPLA(2)epsilon, patatin-like phospholipase domain-containing protein 3, acylglycerol O-acyltransferase, adiponutrin, calcium-independent phospholipase A2-epsilon, iPLA2-epsilon, iPLA2epsilon
Species: human

Top Publications

  1. pmc PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease
    Elizabeth K Speliotes
    Department of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA
    Hepatology 52:904-12. 2010
  2. doi Variant in PNPLA3 is associated with alcoholic liver disease
    Chao Tian
    Perlegen Sciences, Mountain View, California, USA
    Nat Genet 42:21-3. 2010
  3. pmc Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes
    Xin Yuan
    Genetics Division, GlaxoSmithKline, King of Prussia, PA 19406, USA
    Am J Hum Genet 83:520-8. 2008
  4. doi Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent
    S Romeo
    Institute of Metabolic Science, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 0QQ, UK
    Int J Obes (Lond) 34:190-4. 2010
  5. pmc A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents
    Nicola Santoro
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    Hepatology 52:1281-90. 2010
  6. doi Distinct regulation of adiponutrin/PNPLA3 gene expression by the transcription factors ChREBP and SREBP1c in mouse and human hepatocytes
    Céline Dubuquoy
    INSERM, U1016, Institut Cochin, Paris, France
    J Hepatol 55:145-53. 2011
  7. doi A common variant in the PNPLA3 gene is a risk factor for non-alcoholic fatty liver disease in obese Taiwanese children
    Yu Cheng Lin
    Department of Pediatrics, Far Eastern Memorial Hospital, Banqiao City, Taipei County, Taiwan
    J Pediatr 158:740-4. 2011
  8. pmc PNPLA3 polymorphisms and liver aminotransferase levels in a Mexican American population
    Quan Li
    The University of Texas School of Public Health, Brownsville, TX 78520, USA
    Clin Invest Med 35:E237-45. 2012
  9. ncbi Variation in the adiponutrin gene influences its expression and associates with obesity
    Lovisa E Johansson
    Department of Clinical Sciences Malmo, Clinical Obesity, Lund University, University Hospital MAS, S 205 02 Malmo, Sweden
    Diabetes 55:826-33. 2006
  10. ncbi Adiponutrin: A new gene regulated by energy balance in human adipose tissue
    Yong Ming Liu
    Equipe d Accueil 3502 and Institut National de la Santé et de la Recherche Médicale INSERM Avenir and Department de Nutrition, Paris VI University, Paris, France
    J Clin Endocrinol Metab 89:2684-9. 2004

Research Grants

  1. HELEN HASKELL HOBBS; Fiscal Year: 2016
  2. MATTHEW ALVIN MITSCHE; Fiscal Year: 2016
  3. John B Whitfield; Fiscal Year: 2015
  4. Autologus adipose tissue grafts to inhibit hemodialysis access stenosis
    CHRISTI MARIE TERRY; Fiscal Year: 2012
  5. GENCAC - North Carolina Field Center
    Lynne Wagenknecht; Fiscal Year: 2004
  6. ETHANOL METABOLISM IN PREGNANCY--ROLE OF DIET
    Martin Ronis; Fiscal Year: 2005
  7. ETHANOL EFFECTS ON BONE FORMATION IN PREGNANCY
    Martin Ronis; Fiscal Year: 2006
  8. Analysis of Fatty Liver in the Framingham Heart Study Cohort
    ELIZABETH SPELIOTES; Fiscal Year: 2007
  9. Mitochondiral Injury and Anemia in Elderly Patients with Chronic Kidney Disease
    Madhumathi Rao; Fiscal Year: 2008
  10. Contribution of ATGL in skeletal muscle to lipid metabolism and insulin action
    ERIN KERSHAW; Fiscal Year: 2008

Detail Information

Publications151 found, 100 shown here

  1. pmc PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease
    Elizabeth K Speliotes
    Department of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA
    Hepatology 52:904-12. 2010
    ..The G allele of rs738409 in PNPLA3 was associated with increased odds of histologic NAFLD (odds ratio [OR] = 3.26, 95% confidence intervals [CI] = 2...
  2. doi Variant in PNPLA3 is associated with alcoholic liver disease
    Chao Tian
    Perlegen Sciences, Mountain View, California, USA
    Nat Genet 42:21-3. 2010
    Two genome-wide association studies (GWAS) have described associations of variants in PNPLA3 with nonalcoholic fatty liver and plasma liver enzyme levels...
  3. pmc Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes
    Xin Yuan
    Genetics Division, GlaxoSmithKline, King of Prussia, PA 19406, USA
    Am J Hum Genet 83:520-8. 2008
    ..two loci influencing plasma levels of alanine-aminotransferase (ALT) (CPN1-ERLIN1-CHUK on chromosome 10 and PNPLA3-SAMM50 on chromosome 22), one locus influencing gamma-glutamyl transferase (GGT) levels (HNF1A on chromosome 12), ..
  4. doi Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent
    S Romeo
    Institute of Metabolic Science, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 0QQ, UK
    Int J Obes (Lond) 34:190-4. 2010
    The PNPLA3 I148M variant (rs738409) is robustly associated with hepatic steatosis...
  5. pmc A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents
    Nicola Santoro
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    Hepatology 52:1281-90. 2010
    ..Recently, a nonsynonymous single-nucleotide polymorphism (rs738409), in the patatin-like phospholipase 3 gene (PNPLA3) has been associated with hepatic steatosis in adults...
  6. doi Distinct regulation of adiponutrin/PNPLA3 gene expression by the transcription factors ChREBP and SREBP1c in mouse and human hepatocytes
    Céline Dubuquoy
    INSERM, U1016, Institut Cochin, Paris, France
    J Hepatol 55:145-53. 2011
    The adiponutrin/PNPLA3 (patatin-like phospholipase domain-containing protein 3) variant I148M has recently emerged as an important marker of human fatty liver disease...
  7. doi A common variant in the PNPLA3 gene is a risk factor for non-alcoholic fatty liver disease in obese Taiwanese children
    Yu Cheng Lin
    Department of Pediatrics, Far Eastern Memorial Hospital, Banqiao City, Taipei County, Taiwan
    J Pediatr 158:740-4. 2011
    To test the hypothesis that the presence of the PNPLA3 rs738409 G allele would increase the susceptibility of non-alcoholic fatty liver disease (NAFLD) in obese Taiwanese children.
  8. pmc PNPLA3 polymorphisms and liver aminotransferase levels in a Mexican American population
    Quan Li
    The University of Texas School of Public Health, Brownsville, TX 78520, USA
    Clin Invest Med 35:E237-45. 2012
    This study examined genetic associations of patatin-like phospholipase domain containing 3 gene (PNPLA3) polymorphisms and liver aminotransferases in an extensively documented, randomly recruited Mexican American population at high risk ..
  9. ncbi Variation in the adiponutrin gene influences its expression and associates with obesity
    Lovisa E Johansson
    Department of Clinical Sciences Malmo, Clinical Obesity, Lund University, University Hospital MAS, S 205 02 Malmo, Sweden
    Diabetes 55:826-33. 2006
    b>Adiponutrin is one of three recently identified adipocyte lipases. Surprisingly, these proteins also retain transacylase activity, a hitherto unknown pathway of triacylglycerol synthesis in the adipocytes...
  10. ncbi Adiponutrin: A new gene regulated by energy balance in human adipose tissue
    Yong Ming Liu
    Equipe d Accueil 3502 and Institut National de la Santé et de la Recherche Médicale INSERM Avenir and Department de Nutrition, Paris VI University, Paris, France
    J Clin Endocrinol Metab 89:2684-9. 2004
    b>Adiponutrin is a newly identified nonsecreted adipocyte protein regulated by changes in energy balance in rodents. We documented the influence of energy balance modification on adiponutrin gene expression in humans...
  11. ncbi Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities
    Christopher M Jenkins
    Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 279:48968-75. 2004
    ..consensus sequence motifs identified a novel subfamily of three putative iPLA2/lipase family members designated iPLA2epsilon, iPLA2zeta, and iPLA2eta (previously named adiponutrin, TTS-2...
  12. ncbi Expression, regulation, and triglyceride hydrolase activity of Adiponutrin family members
    Andrew C Lake
    Biological Technologies, Wyeth Research, Cambridge, MA 02140, USA
    J Lipid Res 46:2477-87. 2005
    b>Adiponutrin and a related protein, adipocyte triglyceride lipase (ATGL; also known as Desnutrin), were recently described as adipocyte-specific proteins with lipid hydrolase activity...
  13. ncbi Characterization of the human patatin-like phospholipase family
    Paul A Wilson
    Bioinformatics Discovery and Analysis, GlaxoSmithKline Research and Development, Stevenage, England SG1 2NY, UK
    J Lipid Res 47:1940-9. 2006
    ..Given the observed conservation of the patatin fold and lipase motif in all human PNPLAs, a single nomenclature to describe the PNPLA family is proposed...
  14. doi Polymorphisms in the adiponutrin gene are associated with increased insulin secretion and obesity
    Lovisa E Johansson
    Department of Clinical Sciences Malmo, Malmö University Hospital MAS, Lund University, Malmo, Sweden
    Eur J Endocrinol 159:577-83. 2008
    The insulin responsive adiponutrin or patatin-like phospholipase 3 (PNPLA3, previously ADPN) gene shows association with obesity and in vitro adipocyte lipolysis...
  15. pmc Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
    Stefano Romeo
    Donald W Reynolds Cardiovascular Clinical Research Center, Eugene McDermott Center for Human Growth and Development, Dallas, TX 75390, USA
    Nat Genet 40:1461-5. 2008
    ..An allele in PNPLA3 (rs738409[G], encoding I148M) was strongly associated with increased hepatic fat levels (P = 5...
  16. pmc Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions
    Petra C Kienesberger
    Institute of Molecular Biosciences, University of Graz, 8010 Graz, Austria
    J Lipid Res 50:S63-8. 2009
    ..This review aims to summarize current knowledge of PNPLA proteins and to document their emerging importance in lipid and energy homeostasis...
  17. doi A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans
    A Kotronen
    Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland
    Diabetologia 52:1056-60. 2009
    It has recently been suggested that the rs738409 G allele in PNPLA3, which encodes adiponutrin, is strongly associated with increased liver fat content in three different ethnic groups...
  18. doi Prediction of non-alcoholic fatty liver disease and liver fat using metabolic and genetic factors
    Anna Kotronen
    Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland
    Gastroenterology 137:865-72. 2009
    ..disease (NAFLD) and liver fat content based on routinely available clinical and laboratory data and to test whether knowledge of the recently discovered genetic variant in the PNPLA3 gene (rs738409) increases accuracy of the prediction.
  19. doi Tri-iodothyronine upregulates adiponutrin mRNA expression in rat and human adipocytes
    R M Calvo
    Instituto de Investigaciones Biomédicas Madrid, CSIC, Arturo Duperier, 4, 28029 Madrid, Spain
    Mol Cell Endocrinol 311:39-46. 2009
    b>Adiponutrin (PNPLA3) is expressed in adipose tissue. Although its precise function is unknown, some data suggest a dual role in lipid homeostasis...
  20. pmc Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene
    Konstantinos Kantartzis
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tubingen, Tubingen, Germany
    Diabetes 58:2616-23. 2009
    ..scan, the rs738409 C>G single nucleotide polymorphism (SNP) in the patatin-like phospholipase 3 gene (PNPLA3) was strongly associated with increased liver fat but not with insulin resistance estimated from fasting values...
  21. pmc Genetic evidence for a role of adiponutrin in the metabolism of apolipoprotein B-containing lipoproteins
    Barbara Kollerits
    Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck, Austria
    Hum Mol Genet 18:4669-76. 2009
    b>Adiponutrin (PNPLA3) is a predominantly liver-expressed transmembrane protein with phospholipase activity that is regulated by fasting and feeding...
  22. pmc A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity
    Silvia Sookoian
    Laboratory of Clinical and Molecular Hepatology, Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research, University of Buenos Aires CONICET, Ciudad Autonoma de Buenos Aires, Argentina
    J Lipid Res 50:2111-6. 2009
    We explored the role of the adiponutrin (PNPLA3) nonsynonymous-rs738409 single nucleotide polymorphism (SNP) in genetic susceptibility to nonalcoholic fatty liver disease (NAFLD) and whether this SNP contributes to the severity of ..
  23. pmc A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis
    Shaoqing He
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 285:6706-15. 2010
    ..Previously, we showed that a missense mutation (I148M) in PNPLA3 (patatin-like phospholipase domain-containing 3 protein) is associated with increased hepatic triglyceride content ..
  24. doi Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease
    Luca Valenti
    Department of Internal Medicine, Università degli Studi Milano, UO Medicina Interna 1B, Fondazione Ospedale Policlinico MaRE Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy
    Hepatology 51:1209-17. 2010
    ..predisposition to nonalcoholic fatty liver disease (NAFLD), and the rs738409 C-->G polymorphism of PNPLA3/adiponutrin, encoding for the isoleucine-to-methionine substitution at residue 148 (I148M) protein variant, has recently ..
  25. doi The 148M allele of the PNPLA3 gene is associated with indices of liver damage early in life
    Stefano Romeo
    Endocrinology and Diabetes, Department of Medical Sciences, University of Cagliari, Cagliari, Italy
    J Hepatol 53:335-8. 2010
    ..Non-alcoholic fatty liver disease (NAFLD) is frequently associated with obesity in children. Recently, the PNPLA3 gene I148M (rs738409) variant was demonstrated to be strongly associated with hepatic steatosis in obese adults...
  26. pmc On the use of variance per genotype as a tool to identify quantitative trait interaction effects: a report from the Women's Genome Health Study
    Guillaume Pare
    Department of Pathology and Molecular Medicine, Population Genomics Program, McMaster University, Hamilton, Canada
    PLoS Genet 6:e1000981. 2010
    ..levels, between the ICAM1 SNP rs1799969 and smoking in the prediction of soluble ICAM-1 levels, and between the PNPLA3 SNP rs738409 and body mass index in the prediction of soluble ICAM-1 levels...
  27. doi I148M patatin-like phospholipase domain-containing 3 gene variant and severity of pediatric nonalcoholic fatty liver disease
    Luca Valenti
    Department of Internal Medicine, Universita degli Studi, Ospedale Maggiore Policlinico Ca Granda Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy
    Hepatology 52:1274-80. 2010
    ..Recently, the rs738409 C>G adiponutrin/patatin-like phospholipase domain-containing 3 (PNPLA3) polymorphism, which encodes the I148M protein variant ..
  28. pmc The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease
    Yaron Rotman
    Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1800, USA
    Hepatology 52:894-903. 2010
    ..C/G, a nonsynonymous coding SNP in the patatin-like phospholipase domain-containing protein 3 (PNPLA3) (adiponutrin) gene encoding an Ile148Met change, was associated with steatosis (P = 0.03), portal inflammation (P = 2...
  29. doi Specifically PNPLA3-mediated accumulation of liver fat in obese patients with type 2 diabetes
    Jean Michel Petit
    Universite de Bourgogne, Centre de Recherche Institute National de la Santé, Dijon Cedex, France
    J Clin Endocrinol Metab 95:E430-6. 2010
    Recently, it has been shown in the general population that an allele in the adiponutrin (PNPLA3) gene was strongly associated with increased liver fat content (LFC), independently of visceral adiposity and insulin resistance.
  30. pmc Effects of PNPLA3 on liver fat and metabolic profile in Hispanic children and adolescents
    Michael I Goran
    Department of Preventive Medicine, Childhood Obesity Research Center, University of Southern California, Los Angeles, California, USA
    Diabetes 59:3127-30. 2010
    A genome-wide study of adults identified a variant of PNPLA3 (rs738409) associated with ∼twofold higher liver fat...
  31. pmc Increased hepatic fat in overweight Hispanic youth influenced by interaction between genetic variation in PNPLA3 and high dietary carbohydrate and sugar consumption
    Jaimie N Davis
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Am J Clin Nutr 92:1522-7. 2010
    Recently, a genetic variant (rs738409; C→G) of the PNPLA3 gene was identified to be associated with increased hepatic fat deposition, and the effect was more pronounced in Hispanics...
  32. doi Regulation of the promoter region of the human adiponutrin/PNPLA3 gene by glucose and insulin
    Sharleen M Rae-Whitcombe
    Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Biochem Biophys Res Commun 402:767-72. 2010
    The adiponutrin/PNPLA3 gene is highly expressed in adipose tissue and liver. Its expression is down-regulated by fasting and rapidly induced by refeeding a high carbohydrate diet...
  33. doi Variant adiponutrin (PNPLA3) represents a common fibrosis risk gene: non-invasive elastography-based study in chronic liver disease
    Marcin Krawczyk
    Department of Medicine II, Saarland University Hospital, Homburg, Germany
    J Hepatol 55:299-306. 2011
    Recent genome-wide association studies have identified the variant p.I148M of the adiponutrin gene PNPLA3 as a risk factor for developing severe forms of non-alcoholic and alcoholic liver diseases...
  34. pmc Association of the rs738409 polymorphism in PNPLA3 with liver damage and the development of nonalcoholic fatty liver disease
    Kikuko Hotta
    EBM Research Center, Kyoto University Graduate School of Medicine, Japan
    BMC Med Genet 11:172. 2010
    ..association scan, the single-nucleotide polymorphism (SNP) rs738409 in the patatin-like phospholipase 3 gene (PNPLA3) was strongly associated with increased liver fat content...
  35. doi Viral genotype-specific role of PNPLA3, PPARG, MTTP, and IL28B in hepatitis C virus-associated steatosis
    Tao Cai
    Infectious Diseases Service, Department of Medicine, University Hospital and University of Lausanne, Switzerland
    J Hepatol 55:529-35. 2011
    ..steatosis in chronic hepatitis C has been limited by the studies' small sample size, and important single nucleotide polymorphisms (SNPs), such as those in the patatin-like phospholipase family 3 protein (PNPLA3), were never evaluated.
  36. doi Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians
    Felix Stickel
    Institute of Clinical Pharmacology and Visceral Research, University of Bern, Bern, Switzerland
    Hepatology 53:86-95. 2011
    A recent genome-wide study revealed an association between variation in the PNPLA3 gene and liver fat content...
  37. pmc Association of PNPLA3 with non-alcoholic fatty liver disease in a minority cohort: the Insulin Resistance Atherosclerosis Family Study
    Lynne E Wagenknecht
    Division of Public Health Sciences, Wake Forest University Baptist Medical Center, Winston Salem, NC 27157, USA
    Liver Int 31:412-6. 2011
    Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent condition, particularly among Hispanic Americans. A genetic variant in PNPLA3 (rs738409) has been identified as a strong predictor of hepatic fat content.
  38. doi Patatin-like phospholipase domain-containing 3 I148M polymorphism, steatosis, and liver damage in chronic hepatitis C
    Luca Valenti
    Department of Internal Medicine, Universita degli Studi, Fondazione IRCCS Ospedale Maggiore Policlinico Ca Granda IRCCS, Milan, Italy
    Hepatology 53:791-9. 2011
    ..The rs738409 C>G patatin-like phospholipase domain-containing 3 (PNPLA3) single nucleotide polymorphism (SNP), encoding for the I148M protein variant, influences liver fat without ..
  39. doi Common polymorphism in the PNPLA3/adiponutrin gene confers higher risk of cirrhosis and liver damage in alcoholic liver disease
    Eric Trépo
    Department of Gastroenterology, Hepatopancreatology and Digestive Oncology, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    J Hepatol 55:906-12. 2011
    A recent genome-wide association study identified genetic polymorphism (rs738409 C>G) in the PNPLA3/adiponutrin gene associated with liver steatosis...
  40. doi Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease
    Silvia Sookoian
    Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari IDIM, University of Buenos Aires National Council of Scientific and Technological Research CONICET, Ciudad Autonoma de Buenos Aires, Argentina
    Hepatology 53:1883-94. 2011
    ..to estimate the strength of the effect of the I148M (rs738409 C/G) patatin-like phospholipase domain containing 3 (PNPLA3) variant on nonalcoholic fatty liver (NAFLD) and disease severity across different populations...
  41. pmc Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits
    Elizabeth K Speliotes
    Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS Genet 7:e1001324. 2011
    ..liver disease (NAFLD) clusters in families, but the only known common genetic variants influencing risk are near PNPLA3. We sought to identify additional genetic variants influencing NAFLD using genome-wide association (GWA) analysis ..
  42. doi Impact of patatin-like phospholipase-3 (rs738409 C>G) polymorphism on fibrosis progression and steatosis in chronic hepatitis C
    Eric Trépo
    Department of Gastroenterology, Hepatopancreatology, and Digestive Oncology, Erasme Hospital, Brussels, Belgium
    Hepatology 54:60-9. 2011
    ..A recent genome-wide association study identified a genetic variant in the patatin-like phospholipase-3 (PNPLA3) gene (rs738409 C>G) associated with steatosis that was further demonstrated to influence severity of fibrosis ..
  43. doi Genetic variation in PNPLA3 (adiponutrin) confers sensitivity to weight loss-induced decrease in liver fat in humans
    Ksenia Sevastianova
    Minerva Foundation Institute for Medical Research, Helsinki, Finland
    Am J Clin Nutr 94:104-11. 2011
    The rs738409 C→G single nucleotide polymorphism in the patatin-like phospholipase domain-containing 3 (PNPLA3; adiponutrin) leads to a missense mutation (I148M), which is associated with increased liver fat but not insulin resistance...
  44. pmc Association of PNPLA3 SNP rs738409 with liver density in African Americans with type 2 diabetes mellitus
    A J Cox
    Center for Human Genomics, Wake Forest School of Medicine, Winston Salem, NC, USA
    Diabetes Metab 37:452-5. 2011
    ..2 diabetes mellitus (T2DM), and has been associated with the single nucleotide polymorphism (SNP) rs738409 in the PNPLA3 gene...
  45. doi The PNPLA3 I148M polymorphism is associated with insulin resistance and nonalcoholic fatty liver disease in a normoglycaemic population
    Chih Wen Wang
    Graduate Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan
    Liver Int 31:1326-31. 2011
    The adiponutrin/patatin-like phospholipase-3 (PNPLA3) I148M polymorphism has recently been found to contribute to differences in hepatic lipid content...
  46. doi PNPLA3 rs738409C/G polymorphism in cirrhosis: relationship with the aetiology of liver disease and hepatocellular carcinoma occurrence
    Edmondo Falleti
    Department of Medical Sciences Experimental and Clinical, University of Udine, Udine, Italy
    Liver Int 31:1137-43. 2011
    The PNPLA3 rs738409 C>G polymorphism has been found to be strongly associated with non-alcoholic fatty liver disease and with alcoholic liver disease...
  47. doi PNPLA3 polymorphism influences liver fibrosis in unselected patients with type 2 diabetes
    Jean M Petit
    Centre de Recherche, INSERM Unité 866, Universite de Bourgogne, CHU du Bocage, Dijon, France
    Liver Int 31:1332-6. 2011
    Recently, it has been shown that an allele in the adiponutrin (PNPLA3) gene was strongly associated with increased liver fat content (LFC) and liver fibrosis independent of visceral adiposity and insulin resistance.
  48. doi The APOC3 T-455C and C-482T promoter region polymorphisms are not associated with the severity of liver damage independently of PNPLA3 I148M genotype in patients with nonalcoholic fatty liver
    Luca Valenti
    Department of Internal Medicine, Università degli Studi Milano, UO Medicina Interna 1B, Ospedale Maggiore Ca Granda Fondazione Policlinico IRCCS, Milan, Italy
    J Hepatol 55:1409-14. 2011
    ..The aim was to assess the association between APOC3 SNPs and liver damage in Caucasian patients...
  49. ncbi The common adiponutrin variant p.I148M does not confer gallstone risk but affects fasting glucose and triglyceride levels
    M Krawczyk
    Department of Medicine II, Saarland University Hospital, Saarland University, Homburg, Germany
    J Physiol Pharmacol 62:369-75. 2011
    Recently the common adiponutrin (PNPLA3) polymorphism p.I148M has been identified as a genetic determinant of severe forms of non-alcoholic fatty liver disease and alcoholic liver disease...
  50. pmc The PNPLA3 rs738409 148M/M genotype is a risk factor for liver cancer in alcoholic cirrhosis but shows no or weak association in hepatitis C cirrhosis
    Hans Dieter Nischalke
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    PLoS ONE 6:e27087. 2011
    An isoleucine>methionine mutation at position 148 in the PNPLA3 gene (p.I148M, rs738409) has recently been identified as a susceptibility factor for liver damage in steatohepatitis...
  51. pmc Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents
    Nicola Santoro
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    Hepatology 55:781-9. 2012
    ..Moreover, because recently rs738409 in the PNPLA3 and rs2854116 in the APOC3 were associated with fatty liver, we explored how the GCKR SNP and these two variants ..
  52. pmc The association of PNPLA3 variants with liver enzymes in childhood obesity is driven by the interaction with abdominal fat
    Emanuele Miraglia del Giudice
    Department of Pediatrics, Seconda Universita degli Studi di Napoli, Napoli, Italy
    PLoS ONE 6:e27933. 2011
    A polymorphism in adiponutrin/patatin-like phospholipase-3 gene (PNPLA3), rs738409 C->G, encoding for the I148M variant, is the strongest genetic determinant of liver fat and ALT levels in adulthood and childhood obesity...
  53. doi Genetic variation in PNPLA3 but not APOC3 influences liver fat in non-alcoholic fatty liver disease
    Jenni Hyysalo
    Department of Medicine, Division of Diabetes, Helsinki University Central Hospital, Finland
    J Gastroenterol Hepatol 27:951-6. 2012
    ..Our aim was to determine the contribution of genetic variation in APOC3 on liver fat content and plasma triglyceride and apoC3 concentrations in a larger European cohort...
  54. pmc A multi-ethnic study of a PNPLA3 gene variant and its association with disease severity in non-alcoholic fatty liver disease
    Shamsul Mohd Zain
    The Pharmacogenomics Laboratory, Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Hum Genet 131:1145-52. 2012
    The adiponutrin (PNPLA3) rs738409 polymorphism has been found to be associated with susceptibility to non-alcoholic fatty liver disease (NAFLD) in various cohorts...
  55. doi IL28B and PNPLA3 polymorphisms affect histological liver damage in patients with non-alcoholic fatty liver disease
    Salvatore Petta
    Sezione di Gastroenterologia, DiBiMIS, University of Palermo, Italy
    J Hepatol 56:1356-62. 2012
    ..The main outcomes of the study were to assess whether IL28B rs12979860 and rs8099917 polymorphisms, together with PNPLA3 rs738409 C>G polymorphism, are associated with lobular inflammation and fibrosis, in NAFLD patients.
  56. doi PNPLA3 I148M (rs738409) genetic variant is associated with hepatocellular carcinoma in obese individuals
    Maria Antonella Burza
    Department of Molecular and Clinical Medicine and Center for Cardiovascular and Metabolic Research, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Dig Liver Dis 44:1037-41. 2012
    ..Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) genetic variant has been associated with hepatocellular carcinoma (HCC) in individuals with ..
  57. pmc Patatin-like phospholipase domain containing-3 gene I148M polymorphism, steatosis, and liver damage in hereditary hemochromatosis
    Luca Valenti
    Universita degli Studi di Milano, Fondazione Cà Granda IRCCS Ospedale Maggiore Policlinico, 20122 Milano, Italy
    World J Gastroenterol 18:2813-20. 2012
    To investigate whether the patatin-like phospholipase domain containing-3 gene (PNPLA3) I148M polymorphism is associated with steatosis, fibrosis stage, and cirrhosis in hereditary hemochromatosis (HH).
  58. pmc Genetic polymorphisms of the human PNPLA3 gene are strongly associated with severity of non-alcoholic fatty liver disease in Japanese
    Takahisa Kawaguchi
    Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    PLoS ONE 7:e38322. 2012
    ....
  59. pmc Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant
    Colin N A Palmer
    Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, United Kingdom
    PLoS ONE 7:e39362. 2012
    ..The I148M (rs738409) genetic variant of patatin-like phospholipase domain-containing 3 gene (PNPLA3) is known to modulate hepatic triglyceride accumulation, leading to steatosis...
  60. doi Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) affects hepatic VLDL secretion in humans and in vitro
    Carlo Pirazzi
    Sahlgrenska Center for Cardiovascular and Metabolic Research Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Sweden
    J Hepatol 57:1276-82. 2012
    ..The robust association between non-alcoholic fatty liver disease (NAFLD) and the genetic variant I148M (rs738409) in PNPLA3 has been widely replicated...
  61. pmc The I148M PNPLA3 polymorphism influences serum adiponectin in patients with fatty liver and healthy controls
    Luca Valenti
    Department of Internal Medicine, Università degli Studi Milano, UO Medicina Interna 1B, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
    BMC Gastroenterol 12:111. 2012
    ..liver disease (NAFLD) and steatohepatitis (NASH), and the I148M Patatin-like phospholipase domain-containing 3 (PNPLA3) polymorphism predisposes to NAFLD and liver damage progression in NASH and chronic hepatitis C (CHC) by still ..
  62. pmc Genetic variant I148M in PNPLA3 is associated with the ultrasonography-determined steatosis degree in a Chinese population
    Yiling Li
    Department of Gastroenterology, First Affiliated Hospital of China Medical University, Shenyang, China
    BMC Med Genet 13:113. 2012
    ..single nucleotide polymorphism rs738409 (I148M) in patatin-like phospholipase domain-containing protein 3 (PNPLA3) predisposes susceptibility to NAFLD; however, its association with steatosis grade is inconsistent in the ..
  63. doi PNPLA3 I148M variant and hepatocellular carcinoma: a common genetic variant for a rare disease
    Luca Valenti
    Department of Pathophysiology and Transplantation, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, Section of Internal Medicine, Italy
    Dig Liver Dis 45:619-24. 2013
    ..The rs738409 genetic variant in the patatin-like phospholipase domain-containing 3 (PNPLA3, adiponutrin) gene has been implicated as a genetic determinant of the entire spectrum of liver diseases, ranging from ..
  64. doi A gene variant of PNPLA3, but not of APOC3, is associated with histological parameters of NAFLD in an obese population
    A Verrijken
    Department of Endocrinology, Diabetology and Metabolism, Antwerp University Hospital, University of Antwerp, Belgium
    Obesity (Silver Spring) 21:2138-45. 2013
    ..We studied the association between the genes patatin-like phospholipase domain-containing protein 3 (PNPLA3) and apolipoprotein C3 (APOC3) and metabolic and histological parameters of NAFLD in obese patients.
  65. doi Genome-wide scan revealed that polymorphisms in the PNPLA3, SAMM50, and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan
    Takuya Kitamoto
    EBM Research Center, Kyoto University Graduate School of Medicine, Yoshida Konoecho, Sakyo ku, Kyoto 606 8501, Japan
    Hum Genet 132:783-92. 2013
    ..Rs738409 in the PNPLA3 gene was most strongly associated with NAFLD after adjustment (P = 6.8 × 10(-14), OR = 2.05)...
  66. doi Circulating triacylglycerol signatures in nonalcoholic fatty liver disease associated with the I148M variant in PNPLA3 and with obesity
    Jenni Hyysalo
    Department of Medicine, University of Helsinki, Helsinki, Finland
    Diabetes 63:312-22. 2014
    ..relative concentrations of circulating triacylglycerols (TAGs) between carriers compared with noncarriers of PNPLA3(I148M) gene variant display deficiency of TAGs, which accumulate in the liver because of defective lipase activity...
  67. doi PNPLA3-associated steatohepatitis: toward a gene-based classification of fatty liver disease
    Marcin Krawczyk
    Department of Medicine II, Saarland University Medical Center, Homburg, Germany
    Semin Liver Dis 33:369-79. 2013
    ..Recently, the common variant p.I148M of the enzyme adiponutrin (PNPLA3) has emerged as a major genetic determinant of hepatic steatosis and nonalcoholic steatohepatitis as ..
  68. pmc PNPLA3 I148M polymorphism and progressive liver disease
    Paola Dongiovanni
    Paola Dongiovanni, Benedetta Donati, Roberta Fares, Rosa Lombardi, Luca Valenti, Internal Medicine, Fondazione IRCCS Ca Granda Ospedale Policlinico Milano, Department of Pathophysiology and Transplantation, Universita degli Studi di Milano, 20122 Milano, Italy
    World J Gastroenterol 19:6969-78. 2013
    The 148 Isoleucine to Methionine protein variant (I148M) of patatin-like phospholipase domain-containing 3 (PNPLA3), a protein is expressed in the liver and is involved in lipid metabolism, has recently been identified as a major ..
  69. doi Recombinant PNPLA3 protein shows triglyceride hydrolase activity and its I148M mutation results in loss of function
    Piero Pingitore
    Department BEST Biologia, Ecologia, Scienze della Terra, Unit of Biochemistry and Molecular Biotechnology, University of Calabria, Via P Bucci 4c, 87036 Arcavacata di Rende, Italy Department of Chemistry and Molecular Biology, University of Gothenburg, PO Box 462, SE 405 30 Goteborg, Sweden
    Biochim Biophys Acta 1841:574-80. 2014
    The patatin-like phospholipase domain containing 3 (PNPLA3, also called adiponutrin, ADPN) is a membrane-bound protein highly expressed in the liver...
  70. doi Genetic variants in GCKR and PNPLA3 confer susceptibility to nonalcoholic fatty liver disease in obese individuals
    Yu Cheng Lin
    Department of Pediatrics, Far Eastern Memorial Hospital, Taipei, Taiwan Y CL and P FC the Departments of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan M HC and Y HN and the Oriental Institute of Technology, New Taipei City, Taiwan Y CL
    Am J Clin Nutr 99:869-74. 2014
    A genome-wide association study identified variants in or near patatin-like phospholipase domain-containing-3 (PNPLA3), neurocan (NCAN), lysophospholipase-like 1 (LYPLAL1), glucokinase regulatory protein (GCKR), and protein phosphatase 1 ..
  71. doi Role of the PNPLA3 I148M polymorphism in nonalcoholic fatty liver disease and fibrosis in Korea
    Sang Soo Lee
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 82 Gumi ro, 173 Beon gil, Bundang gu, Seongnam si, 463 707, Gyeonggi Do, Republic of Korea
    Dig Dis Sci 59:2967-74. 2014
    The role of the patatin-like phospholipase domain-containing 3 (PNPLA3) single-nucleotide polymorphism (SNP), rs738409, in the development and progression of nonalcoholic fatty liver disease (NAFLD) has not been studied in the Korean ..
  72. pmc Effects of rosiglitazone and high fat diet on lipase/esterase expression in adipose tissue
    Wen Jun Shen
    Division of Endocrinology, Stanford University and VA Palo Alto Health Care System, Palo Alto, CA 94304, USA
    Biochim Biophys Acta 1771:177-84. 2007
    ..We found that the relative mRNA levels of ATGL and HSL are the most abundant, being 2-3 fold greater than TGH or ADPN; whereas other intracellular neutral lipase/esterases were expressed at substantially lower levels...
  73. ncbi Adipokine gene expression in brain and pituitary gland
    Michael Wilkinson
    Department of Obstetrics and Gynaecology, Dalhousie University, Halifax, N S, Canada
    Neuroendocrinology 86:191-209. 2007
    ..others, confirmed that the genes for leptin, resistin, adiponectin, FIAF (fasting-induced adipose factor) and adiponutrin are expressed and regulated in these tissues...
  74. ncbi [Analysis of metabolic syndrome and pulse wave velocity in hemodialysis patients: diagnosis of obesity by bioelectrical impedance analysis and a novel risk factor for atherosclerosis]
    Nobuhiro Sasaki
    Kawashima Medical Clinic, Ibaraki, Japan
    Nihon Jinzo Gakkai Shi 51:476-83. 2009
    ..Therefore, we evaluated atherosclerosis and Met S in HD patients using various markers of obesity by means of bioelectrical impedance analysis (BIA) and brachial-ankle PWV(baPWV)...
  75. ncbi Insulin regulation of gene expression and concentrations of white adipose tissue-derived proteins in vivo in healthy men: relation to adiponutrin
    May Faraj
    Laboratoire des dysfonctions Métabolique, Departement de Nutrition, Faculte de Medicine, Universite de Montreal, 2405 Chemin Cote Ste Catherine, Montreal, Quebec, Canada H3T 1A8
    J Endocrinol 191:427-35. 2006
    b>Adiponutrin is a newly described white adipose tissue (WAT)-derived protein whose function and regulation remain widely unclear in humans though it is suggested to be related to insulin sensitivity...
  76. ncbi High serum adiponectin levels during steroid-responsive nephrotic syndrome relapse
    Sevcan A Bakkaloglu
    Department of Pediatric Nephrology, Gazi University, Besevler, 06540 Ankara, Turkey
    Pediatr Nephrol 20:474-7. 2005
    Adiponectin (ADPN), exclusively expressed and secreted from adipocytes, is a recently discovered protein hormone with anti-atherogenic and anti-inflammatory properties in contrast to other well-known adipocytokines...
  77. ncbi Hyperleptinaemia and chronic inflammation after peritonitis predicts poor nutritional status and mortality in patients on peritoneal dialysis
    Man Fai Lam
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, NO 102, Pokfulam Road, Hong Kong
    Nephrol Dial Transplant 22:1445-50. 2007
    ..The nutritional status of PD patients may further be worsened following peritonitis. We investigated the association between hyperleptinaemia, inflammation and malnourishment in PD-related peritonitis...
  78. ncbi Accessory deep peroneal nerve - a clinically significant anomaly?
    Szymon Owsiak
    Department of Neurology, Medical University of Warsaw, Warsaw, Poland
    Neurol Neurochir Pol 42:112-5. 2008
    The accessory deep peroneal nerve (ADPN), a variant of the peroneal nerve, may give motor branches to the extensor digitorum brevis muscle (EDB) in 19-28% of the general population and in up to 78% of subjects in familial cases...
  79. doi The expression level of non-alcoholic fatty liver disease-related gene PNPLA3 in hepatocytes is highly influenced by hepatic lipid status
    Menno Hoekstra
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, Leiden, The Netherlands
    J Hepatol 52:244-51. 2010
    Recent studies have suggested that variations in PNPLA3 are associated with non-alcoholic fatty liver disease (NAFLD)...
  80. ncbi Adiponectin levels and atherosclerotic risk factors in pediatric chronic peritoneal dialysis patients
    Sevcan A Bakkaloglu
    Department of Pediatric Nephrology, Gazi University, Ankara, Turkey
    Perit Dial Int 25:357-61. 2005
    ..Adiponectin (ADPN) is a recently discovered adipocyte-derived plasma protein having anti-atherogenic properties...
  81. doi Resistin differentially modulates neuropeptide gene expression and AMP-activated protein kinase activity in N-1 hypothalamic neurons
    Russell E Brown
    Department of Obstetrics and Gynaecology, Dalhousie University, IWK Health Centre, 5850 5980 University Avenue, PO Box 9700, Halifax, Nova Scotia B3K 6R8, Canada
    Brain Res 1294:52-60. 2009
    ..and the N-1 hypothalamic neuronal cell line, also expressed several adipokines, including resistin and adiponectin (ADPN). These data suggested that they might also impact brain function and metabolism...
  82. pmc Effects of long-term ethanol administration in a rat total enteral nutrition model of alcoholic liver disease
    Martin J J Ronis
    epartment of Pharmacology and Toxicology, 2University of Arkansas for Medical Sciences and Arkansas Children s Nutrition Center, Little Rock, Arkansas 72202, USA
    Am J Physiol Gastrointest Liver Physiol 300:G109-19. 2011
    ..5 ± 0.6 vs. 2.7 ± 1.2), associated with suppression of the triglyceride hydrolyzing protein adiponutrin, but produced no elevation in serum alanine aminotransferase (ALT)...
  83. ncbi Oleoyl-estrone treatment to late pregnant and mid-lactating rats affects the expression of lipid metabolism genes
    Beatriz García-Peláez
    Departament de Nutrició i Bromatologia, Facultat de Biologia, Universitat de Barcelona, Av Diagonal, 645, 08028, Barcelona, Spain
    Lipids 42:827-33. 2007
    ..The expression of LPL, FATP1, FABP4, HSL, ACC1, FAS, PEPCK, GLUT4, PDK4, SREBP1c, adiponutrin and leptin, were compared with their expression in virgin rats...
  84. ncbi Adiponectin, metabolic risk factors, and cardiovascular events among patients with end-stage renal disease
    Carmine Zoccali
    National Research Council Center of Clinical Physiology, Reggio Calabria, Italy
    J Am Soc Nephrol 13:134-41. 2002
    Adiponectin (ADPN), which is a secretory protein of adipose tissue, attenuates endothelial inflammatory responses in vitro...
  85. ncbi Increased serum adiponectin levels in type 1 diabetic patients with microvascular complications
    J Frystyk
    Medical Research Laboratories, Clinical Institute and Medical Department M Diabetes and Endocrinology, Aarhus University Hospital, Aarhus C, Denmark
    Diabetologia 48:1911-8. 2005
    Low serum adiponectin (ADPN) has been associated with increased risk of cardiovascular disease (CVD) and retinopathy in patients with type 2 diabetes mellitus...
  86. ncbi Adiponectin levels and arteriosclerotic risk factors in pediatric renal transplant recipients
    Sevcan A Bakkaloglu
    Department of Pediatric Nephrology, Gazi University, Ankara, Turkey
    Pediatr Transplant 10:187-92. 2006
    b>ADPN, a recently discovered adipocytokine, has attracted great attention because of its anti-atherogenic properties...
  87. ncbi Heritability of plasma adiponectin levels and body mass index in twins
    Maurizio Cesari
    Department of Clinical and Experimental Medicine, Clinica Medica 4 University Hospital, University of Padova, Italy
    J Clin Endocrinol Metab 92:3082-8. 2007
    ..Adiponectin is suspected to exert antiatherogenic, antiinflammatory, and insulin-sensitizing effects. However, the relative importance of the genetic and environmental factors in influencing plasma adiponectin levels (ADPN) remains unclear.
  88. pmc Plasma adiponectin levels and clinical outcomes among haemodialysis patients
    Madhumathi Rao
    Division of Nephrology, Department of Medicine, Tufts New England Medical Center Hospitals, Box 391, 750 Washington Street, Boston, MA 02111, USA
    Nephrol Dial Transplant 23:2619-28. 2008
    Adiponectin (ADPN) levels are consistently elevated among patients with advanced chronic kidney disease, but its relationship with cardiovascular outcomes in this population remains controversial.
  89. ncbi Paradoxical role for adiponectin in chronic renal diseases? An example of reverse epidemiology
    Joachim Beige
    Hospital St Georg, Divison of Nephrology, 2nd Department of Internal Medicine, Klinikum St Georg, Delitzscher Street 141, 04129 Leipzig, Germany
    Expert Opin Ther Targets 13:163-73. 2009
    Adiponectin (ADPN) is an adipocyte-derived protein with potential antiatherogenic properties...
  90. doi Plasma adiponectin levels in chronic kidney disease patients: relation with molecular inflammatory profile and metabolic status
    G D Norata
    Department of Pharmacological Sciences, University of Milan, Via Balzaretti, 9, 20133 Milan, Italy
    Nutr Metab Cardiovasc Dis 20:56-63. 2010
    Adiponectin (ADPN) exerts anti-inflammatory and cardio protective effects and is associated with decreased cardiovascular risk, however its role in patients with chronic kidney disease is unclear.
  91. pmc A feed-forward loop amplifies nutritional regulation of PNPLA3
    Yongcheng Huang
    Departments of Molecular Genetics and Internal Medicine, The Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 107:7892-7. 2010
    ..Previously, we identified a sequence variant (I148M) in patatin-like phospholipase domain-containing protein 3 (PNPLA3) that confers susceptibility to both hepatic triglyceride (TG) deposition and liver injury...
  92. pmc Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease
    Weiqin Chen
    Diabetes and Endocrinology Research Center, Section of Diabetes and Endocrinology, Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    Hepatology 52:1134-42. 2010
    PNPLA3 (adiponutrin), a novel patatin-like phospholipase domain-containing enzyme, is expressed at high level in fat, but also in other tissues including liver. Polymorphisms in PNPLA3 have been linked to obesity and insulin sensitivity...
  93. ncbi Adiponutrin, a transmembrane protein corresponding to a novel dietary- and obesity-linked mRNA specifically expressed in the adipose lineage
    S Baulande
    Universite Pierre et Marie Curie, UMR Physiologie et Physiopathologie, CNRS, 15 rue de l Ecole de Medecine, 75270 Paris, Cedex 06, France
    J Biol Chem 276:33336-44. 2001
    ..Based on its adipose specificity and dietary regulation, the novel gene product has been designated adiponutrin. The expression of adiponutrin mRNA is also 50-fold elevated in genetically obese fa/fa rats, indicating a link ..
  94. ncbi Association between plasma adiponectin concentration and visceral fat accumulation in hemodialysis patients
    Mari Odamaki
    Department of Clinical Nutrition, School of Food and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan
    Nephron Clin Pract 102:c8-13. 2006
    ..Adiponectin (ADPN) is a recently discovered adipocyte-derived protein that appears to have protective role against atherosclerosis...
  95. pmc Adipose triglyceride lipase: function, regulation by insulin, and comparison with adiponutrin
    Erin E Kershaw
    Division of Endocrinology and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Diabetes 55:148-57. 2006
    ..ATGL shares the greatest sequence homology with adiponutrin, a nutritionally regulated protein of unclear biological function...
  96. doi Association of high-molecular-weight to total adiponectin ratio with pulse wave velocity in hemodialysis patients
    Akihiko Kato
    Division of Blood Purification, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Nephron Clin Pract 109:c18-24. 2008
    High-molecular-weight adiponectin (HMW ADPN) plays an important role in the regulation of insulin action and atherogenic processes, but the role of HMW ADPN remains to be determined in hemodialysis (HD) patients...
  97. doi Serum adiponectin acutely after an ischemic stroke: implications for a long-lasting, suppressed anti-inflammatory role
    S Marousi
    Department of Neurology, University Hospital of Patras, Greece
    Acta Neurol Scand 121:277-84. 2010
    Past ischemic stroke (IS) patients display suppressed adiponectin (ADPN) levels a few months after disease onset...
  98. ncbi Differences in mRNA expression of adipocyte-derived factors in response to fasting, refeeding and leptin
    Fabrice Bertile
    Centre d Ecologie et Physiologie Energetiques, UPR 9010 CNRS, Associé à l Université Louis Pasteur, 23 rue Becquerel, 67087 Strasbourg Cedex 2, France
    Biochim Biophys Acta 1683:101-9. 2004
    ..Leptin, adiponectin, resistin, adiponutrin, and insulin-like growth factor-1 (IGF-1) gene expressions differentially decreased according to the fasting ..
  99. ncbi Inflammatory proteins as predictors of cardiovascular disease in patients with end-stage renal disease
    Carmine Zoccali
    CNR IBIM, Epidemiologia Clinica e Fisiopatologia delle Malattie Renali e dell Ipertensione Arteriosa, Unita Operativa di Nefrologia, Dialisi e Trapianto Renale, Ospedali Riuniti VI piano, 89125 Reggio Calabria, Italy
    Nephrol Dial Transplant 19:V67-72. 2004
    ..interleukin-6, tumour necrosis factor-alpha, as well as adipocyte-specific proteins, leptin and adiponectin (ADPN)...
  100. doi Asymmetric dimethylarginine in obesity after renal transplantation
    Vladimir Teplan
    Department of Nephrology, Transplant Center, Institute for Clinical and Experimental Medicine and Postgraduate Medical School, Prague, Czech Republic
    J Ren Nutr 18:513-20. 2008
    ..We have assessed in obese renal transplant recipients a course of selected proinflammatory factors liable to influence the long-term outcome of transplant patients and kidney grafts...
  101. ncbi [Cloning of human adiponectin gene by PCR-driven overlap extension and expression in Pichia pastoris]
    Bianling Zhang
    Key Laboratory of Resource Biology and Biotechnology in Western China, School of Life Science, Northwest University, Xi an 710069, China
    Sheng Wu Gong Cheng Xue Bao 24:1480-4. 2008
    Gene of human adiponectin (ADPN) was cloned by PCR-driven overlap extension. The ADPN gene was linked into pGEM-T vector. After the sequence was determined, the ADPN gene was subcloned into expression vector pPIC3...

Research Grants14

  1. HELEN HASKELL HOBBS; Fiscal Year: 2016
    ..Recently, we identified a missense mutation (I148M) in patatin-like phospholipase domain-containing protein, PNPLA3 that is strongly associated with both hepatic TG content and hepatic injury...
  2. MATTHEW ALVIN MITSCHE; Fiscal Year: 2016
    ..Patatin-like phospholipase domain containing 3 (PNPLA3) was first implicated in the metabolism of hepatic triacylglycerides (TAGs) when our lab found that a missense ..
  3. John B Whitfield; Fiscal Year: 2015
    ..To date, only one genetic polymorphism (in PNPLA3) has shown replicable positive result as a risk factor for ALC, although evidence from twin studies and Inter-..
  4. Autologus adipose tissue grafts to inhibit hemodialysis access stenosis
    CHRISTI MARIE TERRY; Fiscal Year: 2012
    ..Adipocytes release many peptides, including adiponectin (ADPN) which has beneficial vascular effects, such as decreasing the expression of cellular adhesion molecules and ..
  5. GENCAC - North Carolina Field Center
    Lynne Wagenknecht; Fiscal Year: 2004
    ..This application corresponds to the GENCAC clinic submitted by the Wake Forest University School of Medicine as part of the GENCAC genetic epidemiology network. ..
  6. ETHANOL METABOLISM IN PREGNANCY--ROLE OF DIET
    Martin Ronis; Fiscal Year: 2005
    ....
  7. ETHANOL EFFECTS ON BONE FORMATION IN PREGNANCY
    Martin Ronis; Fiscal Year: 2006
    ..The role of CYP2E1 and free radicals in the skeletal toxicity of ethanol during these periods will also be studied. ..
  8. Analysis of Fatty Liver in the Framingham Heart Study Cohort
    ELIZABETH SPELIOTES; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  9. Mitochondiral Injury and Anemia in Elderly Patients with Chronic Kidney Disease
    Madhumathi Rao; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  10. Contribution of ATGL in skeletal muscle to lipid metabolism and insulin action
    ERIN KERSHAW; Fiscal Year: 2008
    ..Evaluating the role of ATGL-mediated fat breakdown in skeletal muscle will provide important insights into the pathophysiology and treatment of obesity, insulin resistance, and related metabolic disorders. [unreadable] [unreadable]..
  11. INTRA-ABDOMINAL FAT AND RISK OF DISEASE IN ADOLESCENTS
    Michael Goran; Fiscal Year: 2008
    ....
  12. GENETICS OF ADIPOSITY AND GLUCOSE HOMEOSTASIS
    Lynne Wagenknecht; Fiscal Year: 2009
    ..abstract_text> ..
  13. TGF-beta1 and PAI-1 genotypes in Chronic Kidney Disease
    Madhumathi Rao; Fiscal Year: 2008
    ..The proposed training program and research project will prepare her for a career as an independent investigator. ..