PNKD

Summary

Gene Symbol: PNKD
Description: paroxysmal nonkinesigenic dyskinesia
Alias: BRP17, DYT8, FKSG19, FPD1, KIPP1184, MR-1, MR1, PDC, PKND1, TAHCCP2, brain protein 17, myofibrillogenesis regulator 1, trans-activated by hepatitis C virus core protein 2
Species: human

Top Publications

  1. ncbi Presence of alanine-to-valine substitutions in myofibrillogenesis regulator 1 in paroxysmal nonkinesigenic dyskinesia: confirmation in 2 kindreds
    Dong Hui Chen
    Department of Neurology, University of Washington, Seattle, 98195 7720, USA
    Arch Neurol 62:597-600. 2005
  2. ncbi Characterization of MR-1, a novel myofibrillogenesis regulator in human muscle
    Tian Bo Li
    Institute of Medicinal Biotechnology, CAMS and PUMC, Beijing 100050, China
    Acta Biochim Biophys Sin (Shanghai) 36:412-8. 2004
  3. ncbi The gene for paroxysmal non-kinesigenic dyskinesia encodes an enzyme in a stress response pathway
    Hsien Yang Lee
    Department of Neurology, UCSF, San Francisco, CA, USA
    Hum Mol Genet 13:3161-70. 2004
  4. doi Paroxysmal non-kinesigenic dyskinesia is caused by mutations of the MR-1 mitochondrial targeting sequence
    Daniele Ghezzi
    Pierfranco and Luisa Mariani Center for the Study of Children s Mitochondrial Disorders, National Neurological Institute Carlo Besta, Milan, Italy
    Hum Mol Genet 18:1058-64. 2009
  5. ncbi Lipoyl domain-based mechanism for the integrated feedback control of the pyruvate dehydrogenase complex by enhancement of pyruvate dehydrogenase kinase activity
    S Ravindran
    Department of Biochemistry, Kansas State University, Manhattan 66506, USA
    J Biol Chem 271:653-62. 1996
  6. ncbi Parkinsonism, dementia and vertical gaze palsy in a Guamanian with atypical neuroglial degeneration
    K Oyanagi
    Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Japan
    Acta Neuropathol 99:73-80. 2000
  7. ncbi Combination chemotherapy employing bispecific antisense oligonucleotides having binding sites directed against an autocrine regulated growth pathway and bcl-2 for the treatment of prostate tumors
    Marvin Rubenstein
    Division of Cellular Biology, Hektoen Institute for Medical Research, 2100 W Harrison Street, Chicago, IL 60612, USA
    Med Oncol 24:372-8. 2007
  8. doi Comparative study of the activity and kinetic properties of malate dehydrogenase and pyruvate decarboxylase from Candida albicans, Malassezia pachydermatis, and Saccharomyces cerevisiae
    Adam Tylicki
    Institute of Biology, University of Białystok, Swierkowa 20B, 15 950 Białystok, Poland
    Can J Microbiol 54:734-41. 2008
  9. pmc Sera from patients with tuberculosis recognize the M2a-epitope (E2-subunit of pyruvate dehydrogenase) specific for primary biliary cirrhosis
    R Klein
    Medizinische Klinik, University of Tubingen, Germany
    Clin Exp Immunol 92:308-16. 1993
  10. pmc The temporal relationship between glycogen phosphorylase and activation of the pyruvate dehydrogenase complex during adrenaline infusion in resting canine skeletal muscle
    Paul A Roberts
    School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    J Physiol 545:297-304. 2002

Research Grants

  1. MERRILL E GERSHWIN; Fiscal Year: 2015
  2. STUART MICHAEL LEVITZ; Fiscal Year: 2016
  3. Pathways regulating plasmacytoid dendritic cells in Peyers Patches
    Stephanie S Watowich; Fiscal Year: 2013
  4. HIV and Plasmacytoid dendritic cells in the thymus
    Christel Uittenbogaart; Fiscal Year: 2007
  5. Pedram Hamrah; Fiscal Year: 2016
  6. Human Beta-Defensin-1 in HSV-1 Innate Immunity
    LISA KATHLEEN RYAN; Fiscal Year: 2010
  7. Melissa Swiecki; Fiscal Year: 2014
  8. Patricia Fitzgerald-Bocarsly; Fiscal Year: 2014
  9. Boris Reizis; Fiscal Year: 2016
  10. Miriam Merad; Fiscal Year: 2016

Detail Information

Publications260 found, 100 shown here

  1. ncbi Presence of alanine-to-valine substitutions in myofibrillogenesis regulator 1 in paroxysmal nonkinesigenic dyskinesia: confirmation in 2 kindreds
    Dong Hui Chen
    Department of Neurology, University of Washington, Seattle, 98195 7720, USA
    Arch Neurol 62:597-600. 2005
    ..An autosomal dominant form of this disorder was mapped to chromosome 2q33-36, and different missense mutations in exon 1 of the myofibrillogenesis regulator 1 (MR1) gene were identified recently in 2 kindreds.
  2. ncbi Characterization of MR-1, a novel myofibrillogenesis regulator in human muscle
    Tian Bo Li
    Institute of Medicinal Biotechnology, CAMS and PUMC, Beijing 100050, China
    Acta Biochim Biophys Sin (Shanghai) 36:412-8. 2004
    ..These studies suggested that MR-1 might play a regulatory role in the muscle cell and it was worth investigating further...
  3. ncbi The gene for paroxysmal non-kinesigenic dyskinesia encodes an enzyme in a stress response pathway
    Hsien Yang Lee
    Department of Neurology, UCSF, San Francisco, CA, USA
    Hum Mol Genet 13:3161-70. 2004
    ..We report mutations in the myofibrillogenesis regulator 1 (MR-1) gene causing PNKD in 50 individuals from eight families...
  4. doi Paroxysmal non-kinesigenic dyskinesia is caused by mutations of the MR-1 mitochondrial targeting sequence
    Daniele Ghezzi
    Pierfranco and Luisa Mariani Center for the Study of Children s Mitochondrial Disorders, National Neurological Institute Carlo Besta, Milan, Italy
    Hum Mol Genet 18:1058-64. 2009
    Paroxysmal non-kinesigenic dyskinesia (PNKD) is an autosomal-dominant movement disorder characterized by attacks of dystonia, chorea and athetosis...
  5. ncbi Lipoyl domain-based mechanism for the integrated feedback control of the pyruvate dehydrogenase complex by enhancement of pyruvate dehydrogenase kinase activity
    S Ravindran
    Department of Biochemistry, Kansas State University, Manhattan 66506, USA
    J Biol Chem 271:653-62. 1996
    To conserve carbohydrate reserves, the reaction of the pyruvate dehydrogenase complex (PDC) must be down-regulated when the citric acid cycle is provided sufficient acetyl-CoA...
  6. ncbi Parkinsonism, dementia and vertical gaze palsy in a Guamanian with atypical neuroglial degeneration
    K Oyanagi
    Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Japan
    Acta Neuropathol 99:73-80. 2000
    ..The clinical diagnosis was parkinsonism-dementia complex (PDC) with vertical gaze palsy...
  7. ncbi Combination chemotherapy employing bispecific antisense oligonucleotides having binding sites directed against an autocrine regulated growth pathway and bcl-2 for the treatment of prostate tumors
    Marvin Rubenstein
    Division of Cellular Biology, Hektoen Institute for Medical Research, 2100 W Harrison Street, Chicago, IL 60612, USA
    Med Oncol 24:372-8. 2007
    ..we demonstrated that antisense oligonucleotides (oligos) against transforming growth factor-alpha (TGF-alpha [MR1]), its binding site the epidermal growth factor receptor (EGFR [MR2]), and the anti-apoptosis protein bcl-2 (MR4) ..
  8. doi Comparative study of the activity and kinetic properties of malate dehydrogenase and pyruvate decarboxylase from Candida albicans, Malassezia pachydermatis, and Saccharomyces cerevisiae
    Adam Tylicki
    Institute of Biology, University of Białystok, Swierkowa 20B, 15 950 Białystok, Poland
    Can J Microbiol 54:734-41. 2008
    ..We compare the properties of two enzymes, pyruvate decarboxylase (PDC) and malate dehydrogenase (MDH), from these species and from Saccharomyces cerevisiae cultivated under aerobic and ..
  9. pmc Sera from patients with tuberculosis recognize the M2a-epitope (E2-subunit of pyruvate dehydrogenase) specific for primary biliary cirrhosis
    R Klein
    Medizinische Klinik, University of Tubingen, Germany
    Clin Exp Immunol 92:308-16. 1993
    ..of the inner mitochondrial membrane consisting of six epitopes (E2 subunit of the pyruvate dehydrogenase complex (PDC), 70 kD; protein X of the PDC, 56 kD; alpha-ketoglutarate dehydrogenase complex, 52 kD; branched-chain alpha-..
  10. pmc The temporal relationship between glycogen phosphorylase and activation of the pyruvate dehydrogenase complex during adrenaline infusion in resting canine skeletal muscle
    Paul A Roberts
    School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    J Physiol 545:297-304. 2002
    ..of adrenaline infusion on the activation status of glycogen phosphorylase and the pyruvate dehydrogenase complex (PDC) and on the accumulation of glucose-6-phosphate (G-6-P) and acetylcarnitine in resting canine skeletal muscle...
  11. pmc Genetic and biochemical characterization of a 2-pyrone-4, 6-dicarboxylic acid hydrolase involved in the protocatechuate 4, 5-cleavage pathway of Sphingomonas paucimobilis SYK-6
    E Masai
    Department of Bioengineering, Nagaoka University of Technology, Nagaoka, Niigata 940 2188, Japan
    J Bacteriol 181:55-62. 1999
    ..Yamasaki. J. Bacteriol. 172:2704-2709, 1990), we found the ligI gene encoding 2-pyrone-4, 6-dicarboxylic acid (PDC) hydrolase...
  12. pmc The role of residues glutamate-50 and phenylalanine-496 in Zymomonas mobilis pyruvate decarboxylase
    J M Candy
    Department of Biochemistry, University of Queensland, Brisbane, Australia
    Biochem J 315:745-51. 1996
    ..thiamine diphosphate (ThDP) as an essential cofactor, and we have used one of these, pyruvate decarboxylase (PDC; EC 4.1.1.1) from Zymomonas mobilis, as a model for this group of enzymes...
  13. ncbi Serum IgG to heat shock proteins and Porphyromonas gingivalis antigens in diabetic patients with periodontitis
    Tom J Sims
    Department of Oral Medicine, University of Washington, Seattle WA 98195, USA
    J Clin Periodontol 29:551-62. 2002
    ..decarboxylase autoantibody (GAD65 Ab) levels were significantly associated with periodontal pocket depth change (PDC) and 2. serum IgG titers to P...
  14. ncbi Tau-positive fine granules in the cerebral white matter: a novel finding among the tauopathies exclusive to parkinsonism-dementia complex of Guam
    Mineo Yamazaki
    Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Fuchu shi, Tokyo, Japan
    J Neuropathol Exp Neurol 64:839-46. 2005
    We examined the autopsied brains of cases of 6 types of tauopathy: parkinsonism-dementia complex of Guam (PDC), corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), Pick disease, Alzheimer disease (AD), and myotonic ..
  15. doi Dendritic cells--at the front-line of pathogen attack
    Kenneth C McCullough
    Institute of Virology and Immunoprophylaxis, Research Department, Sensemattstrasse 293, CH 3147 Mittelhäusern, Switzerland
    Vet Immunol Immunopathol 128:7-15. 2009
    ..played by dendritic cells (DCs), particularly the interaction between conventional DC (cDC) and plasmacytoid DC (pDC), together with other monocytic cells...
  16. ncbi [Lessons from Guam ALS/PDC study]
    Hirano Asao
    Division of Neuropathology, Montefiore Medical Center, Bronx, New York 10467 2490, USA
    Rinsho Shinkeigaku 47:717-21. 2007
    An extraordinarily high incidence of amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia complex (PDC) affecting the native population was discovered on the island of Guam a half century ago...
  17. ncbi Bispecific antisense oligonucleotides having binding sites directed against an autocrine regulated growth pathway and bcl-2 for the treatment of prostate tumors
    Marvin Rubenstein
    Division of Cellular Biology, Hektoen Institute of Medicine, 2100 W Harrison Street, Chicago, IL, 60612, USA
    Med Oncol 24:189-96. 2007
    Antisense oligonucleotides (oligos) against transforming growth factor-alpha (TGF-alpha) (MR1) and its binding site, the epidermal growth factor receptor (EGFR) (MR2), are efficacious against PC-3 and LNCaP prostate tumors...
  18. ncbi Human plasmacytoid dendritic cells express receptors for anaphylatoxins C3a and C5a and are chemoattracted to C3a and C5a
    Ralf Gutzmer
    Department of Dermatology and Allergology, Hannover Medical School, Hannover, Germany
    J Invest Dermatol 126:2422-9. 2006
    The presence of plasmacytoid dendritic cells (pDC) was recently demonstrated in lesions of inflammatory skin diseases...
  19. pmc Overproduction of threonine aldolase circumvents the biosynthetic role of pyruvate decarboxylase in glucose-limited chemostat cultures of Saccharomyces cerevisiae
    Antonius J A van Maris
    Kluyver Laboratory of Biotechnology, Delft University of Technology, The Netherlands
    Appl Environ Microbiol 69:2094-9. 2003
    Pyruvate decarboxylase-negative (Pdc(-)) mutants of Saccharomyces cerevisiae require small amounts of ethanol or acetate to sustain aerobic, glucose-limited growth...
  20. pmc Characterization of a lipoyl domain-independent B-cell autoepitope on the human branched-chain acyltransferase in primary biliary cirrhosis and overlap syndrome with autoimmune hepatitis
    Antal Csepregi
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Street 1, 30625 Hannover, Germany
    Clin Dev Immunol 10:173-81. 2003
    Antimitochondrial antibodies (AMA) which recognize pyruvate acetyltransferase (PDC-E2) represent a highly diagnostic feature of primary biliary cirrhosis (PBC)...
  21. ncbi Systemic administration of anti-urokinase plasminogen activator receptor monoclonal antibodies induces hepatic fibrin deposition in tissue-type plasminogen activator deficient mice
    A Jogi
    Finsen Laboratory, Rigshospitalet, Copenhagen Biocenter, Copenhagen, Denmark
    J Thromb Haemost 5:1936-44. 2007
    ..We have recently generated an inhibitory monoclonal antibody (mAb) against mouse u-PAR (mR1) by immunization of u-PAR-deficient mice.
  22. doi Beyond Guam: the cyanobacteria/BMAA hypothesis of the cause of ALS and other neurodegenerative diseases
    Walter G Bradley
    Department of Neurology, Miller School of Medicine, University of Miami, 1120 NW 14 Street, Miami, FL 33136, USA
    Amyotroph Lateral Scler 10:7-20. 2009
    ..Research on Guam suggested that ALS, Parkinson's disease and dementia (the ALS/PDC complex) was due to a neurotoxic non-protein amino acid, beta-methylamino-L-alanine (BMAA), in the seeds of the ..
  23. pmc Acetyl group availability influences phosphocreatine degradation even during intense muscle contraction
    James A Timmons
    Department of Physiology and Pharmacology, Berzelius väg 13, Karolinska Institutet, 171 77 Stockholm, Sweden
    J Physiol 561:851-9. 2004
    We previously established that activation of the pyruvate dehydrogenase complex (PDC) using dichloroacetate (DCA) reduced the reliance on substrate-level phosphorylation (SLP) at the onset of exercise, with normal and reduced blood flow...
  24. ncbi [Quantitation of antigen specific T lymphocytes in peripheral blood of patients with primary biliary cirrhosis using tetramer technology]
    Hai Ying Liu
    Clinical Laboratory, General Hospital of Guangzhou, Guangzhou 510010, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 22:78-81. 2006
    ..To quantitate antigen specific T lymphocytes in peripheral blood from patients with primary biliary cirrhosis(PBC) and study the role of antigen specific T lymphocytes in the development of PBC...
  25. ncbi A study on the B cell activity in protein deficient rats exposed to methyl isocyanate vapour
    A K Saxena
    Immunobiology Lab, Industrial Toxicology Research Centre, Lucknow, India
    Immunopharmacol Immunotoxicol 13:413-24. 1991
    ..01) in the protein deficient diet fed control (PDC) ones...
  26. ncbi Breakdown of tolerance to pyruvate dehydrogenase complex in experimental autoimmune cholangitis: a mouse model of primary biliary cirrhosis
    D E Jones
    Centre for Liver Research, University of Newcastle, Framlington Place, Newcastle upon Tyne, UK
    Hepatology 30:65-70. 1999
    ..is characterized by autoreactive responses to a highly conserved self-antigen, pyruvate dehydrogenase complex (PDC)...
  27. ncbi Site-specific phosphorylation of phosducin in intact retina. Dynamics of phosphorylation and effects on G protein beta gamma dimer binding
    Bruce Y Lee
    Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah 84602, USA
    J Biol Chem 279:54008-17. 2004
    Phosducin (Pdc) is a G protein beta gamma dimer (G beta gamma) binding protein, highly expressed in retinal photoreceptor and pineal cells, yet whose physiological role remains elusive...
  28. doi Ca2+ -independent effects of spermine on pyruvate dehydrogenase complex activity in energized rat liver mitochondria incubated in the absence of exogenous Ca2+ and Mg2+
    E Pezzato
    Dipartimento di Chimica Biologica, Università di Padova e Istituto di Neuroscienze, CNR, Viale G Colombo 3, 35121 Padova, Italy
    Amino Acids 36:449-56. 2009
    ..of endogenous Ca(2+), the polyamine spermine is able to stimulate the activity of pyruvate dehydrogenase complex (PDC) of energized rat liver mitochondria (RLM)...
  29. doi Preventive dental care for young, Medicaid-insured children in Washington state
    Charlotte Lewis
    Division of General Pediatrics, Department of Pediatrics, Child Health Institute, School of Public Health, University of Washington, Seattle, Washington 98195, USA
    Pediatrics 124:e120-7. 2009
    Children from low-income families face barriers to preventive dental care (PDC) and are disproportionately affected by dental caries...
  30. ncbi Investigation of a mechanism for accelerated breakdown of immune tolerance to the primary biliary cirrhosis-associated autoantigen, pyruvate dehydrogenase complex
    David E J Jones
    Centre for Liver Research, University of Newcastle, Framlington Place, Newcastle upon Tyne, United Kingdom
    Lab Invest 82:211-9. 2002
    ..by autoreactive T- and B-cell responses to the highly conserved enzyme pyruvate dehydrogenase complex (PDC). In this study we have examined the breakdown of T-cell tolerance to self-PDC using a mouse model...
  31. doi Results of a retrospective database analysis of adherence to statin therapy and risk of nonfatal ischemic heart disease in daily clinical practice in Italy
    Giovanni Corrao
    Department of Statistics, Unit of Biostatistics and Epidemiology, University of Milano Bicocca, Milan, Italy
    Clin Ther 32:300-10. 2010
    ..However, inadequate adherence may reduce statins' protective effects...
  32. pmc Double duty for a conserved glutamate in pyruvate decarboxylase: evidence of the participation in stereoelectronically controlled decarboxylation and in protonation of the nascent carbanion/enamine intermediate
    Danilo Meyer
    Albrecht von Haller Institute for Plant Sciences and Göttingen Center for Molecular Biosciences, Georg August University Gottingen, Ernst Caspari Haus, Justus von Liebig Weg 11, D 37077 Gottingen, Germany
    Biochemistry 49:8197-212. 2010
    Pyruvate decarboxylase (PDC) catalyzes the nonoxidative decarboxylation of pyruvate into acetaldehyde and carbon dioxide and requires thiamin diphosphate (ThDP) and a divalent cation as cofactors...
  33. ncbi Experimental autoimmune cholangitis: a mouse model of immune-mediated cholangiopathy
    D E Jones
    Centre for Liver Research, The Medical School, University of Newcastle, Newcastle upon Tyne, UK
    Liver 20:351-6. 2000
    ..Although auto-reactive immune responses against pyruvate dehydrogenase complex (PDC) have been characterised in PBC, the lack of an animal model of the disease has limited study of the mechanisms of ..
  34. ncbi Bacterial motif DNA as an adjuvant for the breakdown of immune self-tolerance to pyruvate dehydrogenase complex
    David E J Jones
    Centre for Liver Research, University of Newcastle, Framlington Place, Newcastle upon Tyne, England
    Hepatology 36:679-86. 2002
    ..the effects of CpG motif-containing oligodeoxynucleotides (ODN) on responses to pyruvate dehydrogenase complex (PDC, the autoantigen in PBC) in a murine model...
  35. ncbi Magnetic resonance spectroscopic investigation of mitochondrial fuel metabolism and energetics in cultured human fibroblasts: effects of pyruvate dehydrogenase complex deficiency and dichloroacetate
    Nicholas E Simpson
    Department of Medicine, Division of Endocrinology and Metabolism, University of Florida, Gainesville, FL 32610, USA
    Mol Genet Metab 89:97-105. 2006
    The pyruvate dehydrogenase complex (PDC) is integral to metabolism and energetics. Congenital PDC deficiency leads to lactic acidosis, neurological degeneration and early death...
  36. doi Pilot study of peripheral muscle function in primary biliary cirrhosis: potential implications for fatigue pathogenesis
    Kieren G Hollingsworth
    Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, United Kingdom
    Clin Gastroenterol Hepatol 6:1041-8. 2008
    ..in 95% of patients by autoantibody responses directed against the mitochondrial antigen pyruvate dehydrogenase complex (PDC). Although anti-PDC inhibits PDC function in vitro, mitochondrial function in vivo in PBC has not been examined.
  37. ncbi Covalent modification as a mechanism for the breakdown of immune tolerance to pyruvate dehydrogenase complex in the mouse
    Jeremy M Palmer
    Centre for Liver Research, School of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne, UK
    Hepatology 39:1583-92. 2004
    ..PBC) is characterized by the breakdown of normal immune self tolerance to pyruvate dehydrogenase complex (PDC)...
  38. pmc Role of pyruvate dehydrogenase kinase isoenzyme 4 (PDHK4) in glucose homoeostasis during starvation
    Nam Ho Jeoung
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202 5122, USA
    Biochem J 397:417-25. 2006
    The PDC (pyruvate dehydrogenase complex) is strongly inhibited by phosphorylation during starvation to conserve substrates for gluconeogenesis...
  39. doi Identification of PDC-109-like protein(s) in buffalo seminal plasma
    Hiron M Harshan
    Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh 243122, India
    Anim Reprod Sci 115:306-11. 2009
    ..BSP-A1 and BSP-A2, the predominant proteins of the FN-2 family, are collectively termed as PDC-109...
  40. pmc Apotopes and the biliary specificity of primary biliary cirrhosis
    Ana Lleo
    Division of Rheumatology, University of California at Davis, Davis, CA 95616, USA
    Hepatology 49:871-9. 2009
    ..by antimitochondrial antibodies (AMAs), directed to the E2 component of the pyruvate dehydrogenase complex (PDC-E2)...
  41. ncbi Localization and regulation of plasma membrane Ca(2+)-ATPase in bovine spermatozoa
    Jörg Triphan
    Department of Anatomy and Cell Biology, Philipps University, Robert Koch Str 8, D 35037 Marburg, Germany
    Eur J Cell Biol 86:265-73. 2007
    ..We have recently shown that bovine sperm PMCA is stimulated by PDC-109, a secretory protein of bovine seminal vesicles...
  42. doi Xenobiotic incorporation into pyruvate dehydrogenase complex can occur via the exogenous lipoylation pathway
    Hannah R Walden
    Liver Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Hepatology 48:1874-84. 2008
    Lipoylated enzymes such as the E2 component of pyruvate dehydrogenase complex (PDC-E2) are targets for autoreactive immune responses in primary biliary cirrhosis, with lipoic acid itself forming a component of the dominant auto-epitopes...
  43. doi The major protein of bovine seminal plasma, PDC-109, is a molecular chaperone
    Rajeshwer Singh Sankhala
    School of Chemistry, University of Hyderabad, Hyderabad 500046, India
    Biochemistry 49:3908-18. 2010
    The major protein of bovine seminal plasma, PDC-109, binds to choline phospholipids on the sperm plasma membrane and induces the efflux of cholesterol and choline phospholipids, which is an important step in sperm capacitation...
  44. doi Characterization of the p-coumaric acid decarboxylase from Lactobacillus plantarum CECT 748(T)
    Hector Rodriguez
    Departamento de Microbiologia, Instituto de Fermentaciones Industriales, CSIC, Juan de la Cierva 3, 28006 Madrid, Spain
    J Agric Food Chem 56:3068-72. 2008
    ..The p-coumaric acid decarboxylase (PDC) from this strain has been overexpressed and purified...
  45. ncbi Regulation of pyruvate dehydrogenase complex activity in Ehrlich ascites carcinoma cells by Ca2+ and pyruvate
    G L Ermakov
    Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142292, Russia
    Biochemistry (Mosc) 64:318-25. 1999
    The dependence of pyruvate dehydrogenase complex (PDC) activity on [Ca2+] was determined in Ehrlich ascites carcinoma cells at different pyruvate concentrations...
  46. pmc Pyruvate dehydrogenase kinase-4 structures reveal a metastable open conformation fostering robust core-free basal activity
    R Max Wynn
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9038, USA
    J Biol Chem 283:25305-15. 2008
    Human pyruvate dehydrogenase complex (PDC) is down-regulated by pyruvate dehydrogenase kinase (PDK) isoforms 1-4. PDK4 is overexpressed in skeletal muscle in type 2 diabetes, resulting in impaired glucose utilization...
  47. ncbi Anti-CD25 mAb, anti-IL2 mAb, and IL2 block tolerance induction through anti-CD154 mAb and rapamycin in xenogeneic islet transplantation
    H Pan
    Department of General Surgery West China Hospital, Si Chuan University, Chengdu, Sichuan, China
    Transplant Proc 39:3452-4. 2007
    We have used anti-CD154 monoclonal antibody (mAb; MR1) and rapamycin (rapa) to induce tolerance to islet xenografts...
  48. ncbi Comparing adherence and persistence across 6 chronic medication classes
    Jason Yeaw
    IMS Health, 311 Arsenal St, Watertown, MA 02472, USA
    J Manag Care Pharm 15:728-40. 2009
    The National Quality Forum recently endorsed the proportion of days covered (PDC)-a measure of medication adherence-as an indicator of quality in drug therapy management.
  49. doi Circulating myeloid dendritic cells are increased in individuals with severe aplastic anemia
    Shao Zonghong
    Department of Hematology, General Hospital, Tianjin Medical University, 154 Anshandao, Tianjin 300052, Heping, People s Republic of China
    Int J Hematol 93:156-62. 2011
    ..of the study were to investigate the number of myeloid dendritic cells (mDC) and plasmacytoid dendritic cells (pDC) present in peripheral blood mononuclear cells (PBMC) from severe aplastic anemia (SAA) patients before and after ..
  50. ncbi Peripheral blood T-cell responses to pyruvate dehydrogenase complex in primary biliary cirrhosis: role of antigen-presenting dendritic cells
    S M Akbar
    Ehime University School of Medicine, Ehime, Japan, Teikyo University Mizonokuchi Hospital, Kanagawa, Japan
    Eur J Clin Invest 31:639-46. 2001
    ..biliary cirrhosis (PBC) are usually characterized by the presence of antibody to pyruvate dehydrogenase complex (PDC) in the sera and PDC-specific T cells in the liver...
  51. ncbi Peripheral tolerance and the qualitative characteristics of autoreactive T cell clones in primary biliary cirrhosis
    Akira Kawano
    Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    J Immunol 179:3315-24. 2007
    Primary biliary cirrhosis is characterized by autoreactive T cells specific for the mitochondrial Ag PDC-E2(163-176)...
  52. ncbi Li+ protects nerve cells against destabilization of Ca2+ homeostasis and delayed death caused by removal of external Na+
    B Khodorov
    Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow
    FEBS Lett 448:173-6. 1999
    ..Li+ is also able to abolish the [Ca2+]i response induced by PDC which at high concentrations (> 200 microM) is shown to stimulate the release of endogenous Glu...
  53. ncbi Pyruvate decarboxylases from the petite-negative yeast Saccharomyces kluyveri
    K Møller
    Center for Process Biotechnology, BioCentrum DTU, Technical University of Denmark, Building 223, 2800 Lyngby, Denmark
    Mol Genet Genomics 270:558-68. 2004
    ..The regulation of pyruvate decarboxylase in S. kluyveri was studied by measuring the total level of Sk- PDC mRNA and the overall enzyme activity under various growth conditions...
  54. ncbi Transcriptional regulation of pyruvate dehydrogenase kinase 4 in skeletal muscle during and after exercise
    Henriette Pilegaard
    Copenhagen Muscle Research Centre, August Krogh Institute, University of Copenhagen, Universitetsparken 13, 2100 Copenhagen Ø, Denmark
    Proc Nutr Soc 63:221-6. 2004
    The pyruvate dehydrogenase complex (PDC) has a key position in skeletal muscle metabolism as it represents the entry of carbohydrate-derived fuel into the mitochondria for oxidation...
  55. ncbi Decreased frequency and function of circulating plasmocytoid dendritic cells (pDC) in hepatitis B virus infected humans
    Xue Zhang Duan
    Research Centre of Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, Beijing, People s Republic of China
    J Clin Immunol 24:637-46. 2004
    The Type 2 precursor plasmacytoid dendritic cells (pDC) represent the most important cell type in antiviral innate immunity...
  56. ncbi The effects of renal transplantation on circulating precursor dendritic cells
    K L Womer
    Department of Medicine, Gainesville, Florida, USA
    Transplant Proc 37:3-6. 2005
    ..Recent advances allow accurate quantification of peripheral blood (PB) myeloid and plasmacytoid DC populations (mDC and pDC, respectively), although the response to renal transplantation (RT) remains unknown.
  57. ncbi The long-term but not the short-term antiviral effect of IFN-alpha depends on Flt3 ligand and pDC
    Sabine Vollstedt
    Institute for Virology, University of Zurich, Zurich, Switzerland
    Eur J Immunol 36:1231-40. 2006
    ..In C57BL/6 mice, treatment with rIFN-alpha at birth induced both FL and plasmacytoid DC (pDC), resulting in enhanced resistance against HSV-1 at day 7...
  58. ncbi Demonstration of PDC-E1 subunits as major antigens in the complement-fixing fraction M4 and re-evaluation of PDC-E1-specific antibodies in PBC patients
    Christoph P Berg
    Department of Internal Medicine I, Medical Clinic, University of Tubingen, Tubingen, Germany
    Liver Int 26:846-55. 2006
    ..Autoantibodies specific for the mitochondrial M4 antigen can be detected by a complement fixation test (CFT) but not by immunoblotting. The aim of this study was to elucidate the identity of the M4 antigen...
  59. ncbi Use of porcine dermal collagen graft (Permacol) for hernia repair in contaminated fields
    F Catena
    General, Emergency and Transplant Surgery DPT, St Orsola Malpighi University Hospital, Via Massarenti 9, 40138, Bologna, Italy
    Hernia 11:57-60. 2007
    ..Prostheses made of porcine dermal collagen (PDC) have recently been proposed as a means to offset the disadvantages of polypropylene meshes and have since been ..
  60. ncbi Overexpression of myofibrillogenesis regulator-1 aggravates cardiac hypertrophy induced by angiotensin II in mice
    Hong Liang Li
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People s Republic of China
    Hypertension 49:1399-408. 2007
    ..In conclusion, our results suggest that MR-1 plays an aggravative role in the development of cardiac hypertrophy via activation of the nuclear factor kappaB signaling pathway...
  61. ncbi Brain volumes in Guam dementia vs Parkinson dementia complex vs aging Chamorro adults
    J A Kaye
    Departments of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    Neurology 69:196-9. 2007
    ..to determine if Chamorro individuals with a family history of Guam dementia (GD) or Parkinson dementia complex (PDC) exhibit presymptomatic brain MRI changes...
  62. ncbi Exploration of the relationship between phlegm-dampness constitution and polymorphism of low density lipoprotein receptor genes Pvu II and Ava II
    Jing Zhou
    Department of Internal Cardiology, Yueyang Hospital of Integrative Chinese and Western Medicine, Shanghai University of TCM, Shanghai, 200437, China
    Chin J Integr Med 13:170-4. 2007
    To explore the polymorphism of low density lipoprotein receptor (LDL-R) genes Pvu II and Ava II in a population with phlegm-dampness constitution (PDC).
  63. pmc HIV turns plasmacytoid dendritic cells (pDC) into TRAIL-expressing killer pDC and down-regulates HIV coreceptors by Toll-like receptor 7-induced IFN-alpha
    Andrew W Hardy
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:17453-8. 2007
    Plasmacytoid dendritic cells (pDC) are key players in viral immunity and produce IFN-alpha after HIV-1 exposure, which in turn regulates TNF-related apoptosis-inducing ligand (TRAIL) expression by CD4(+) T cells...
  64. ncbi Persistent regional downregulation in mitochondrial enzymes and upregulation of stress proteins in swine with chronic hibernating myocardium
    Brian Page
    VA WNY Health Care System, University at Buffalo, Buffalo, NY, USA
    Circ Res 102:103-12. 2008
    ..downregulation in abundance leading to an amplification of their cumulative effects on activity (eg, "total" LAD PDC activity was 21.9+/-3.1 versus 42.8+/-1.9 mU, P<0.05)...
  65. ncbi Broadband frequency mode entanglement in waveguided parametric downconversion
    Andreas Eckstein
    Max Planck Research Group, Erlangen, Germany
    Opt Lett 33:1825-7. 2008
    ..rate in a Hong-Ou-Mandel interference (HOMI) between signal and idler photons from a parametric downconversion (PDC) process inside a multimode KTP waveguide...
  66. doi Characterisation of myeloid receptor expression and interferon alpha/beta production in murine plasmacytoid dendritic cells by flow cytomtery
    Rosalind E Seeds
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK
    J Immunol Methods 350:106-17. 2009
    ..report also details a flow cytometry-based protocol to measure the production of murine IFNalpha/beta by splenic pDC. Briefly, splenocytes can be stimulated with virus or a TLR9 agonist and IFNalpha/beta production by pDCs is ..
  67. pmc Cathepsin G: roles in antigen presentation and beyond
    Timo Burster
    Division of Endocrinology and Diabetes, Department of Internal Medicine I, Ulm University, Ulm, Germany
    Mol Immunol 47:658-65. 2010
    ..CatG is found in primary human monocytes, B cells, myeloid dendritic cells 1 (mDC1), mDC2, plasmacytoid DC (pDC), and murine microglia, but is not expressed in B cell lines or monocyte-derived DC...
  68. doi Free HTLV-1 induces TLR7-dependent innate immune response and TRAIL relocalization in killer plasmacytoid dendritic cells
    Renaud Colisson
    Centre Nationale de la Recherche Scientifique CNRS Unite Mixte de Recherche UMR 8147, Universite Paris Descartes, Paris, France
    Blood 115:2177-85. 2010
    ..We demonstrate here that cell-free HTLV-1 generated a pDC innate immune response by producing massive levels of IFN-alpha that were inhibited by anti-HTLV-1 antibodies...
  69. pmc Solution structure and characterisation of the human pyruvate dehydrogenase complex core assembly
    S Vijayakrishnan
    Division of Molecular and Cell Biology, Faculty of Biomedical and Life Sciences, Davidson Building, University of Glasgow, Glasgow G12 8QQ, UK
    J Mol Biol 399:71-93. 2010
    Mammalian pyruvate dehydrogenase complex (PDC) is a key multi-enzyme assembly that is responsible for glucose homeostasis maintenance and conversion of pyruvate into acetyl-CoA...
  70. pmc A systems immunology approach to plasmacytoid dendritic cell function in cytopathic virus infections
    Gennady Bocharov
    Institute of Numerical Mathematics, Russian Academy of Sciences, Moscow, Russia
    PLoS Pathog 6:e1001017. 2010
    Plasmacytoid dendritic cell (pDC)-mediated protection against cytopathic virus infection involves various molecular, cellular, tissue-scale, and organism-scale events...
  71. doi The ALS/PDC syndrome of Guam: potential biomarkers for an enigmatic disorder
    Patrick L McGeer
    Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, BC, Canada
    Prog Neurobiol 95:663-9. 2011
    ..There are as yet no identified pathological features that will clearly distinguish the Guam or Kii ALS/PDC syndrome from other degenerative neurological disorders...
  72. doi FLT3 ligand enhances the cancer therapeutic potency of naked RNA vaccines
    Sebastian Kreiter
    Institute for Translational Oncology and Immunology, Mainz, Germany
    Cancer Res 71:6132-42. 2011
    ..Unexpectedly, plasmacytoid DCs (pDC) were found to be essential for the adjuvant effect of FLT3 ligand and they were systemically expanded together ..
  73. doi Association of pyruvate dehydrogenase kinase 4 gene polymorphisms with type 2 diabetes and metabolic syndrome
    Seong Su Moon
    Department of Internal Medicine, Dongguk University School of Medicine, Gyeongju, South Korea
    Diabetes Res Clin Pract 95:230-6. 2012
    ..plays a crucial role in glucose utilization and lipid metabolism by regulating the pyruvate dehydrogenase complex (PDC) and is an emerging therapeutic target for type 2 diabetes...
  74. doi Noncollagenous 16A domain of type XVII collagen-reactive CD4+ T cells play a pivotal role in the development of active disease in experimental bullous pemphigoid model
    Hideyuki Ujiie
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Clin Immunol 142:167-75. 2012
    ..the immune responses against COL17 in active BP model by using anti-CD40 ligand (CD40L) monoclonal antibody MR1, an inhibitor of the CD40-CD40L interaction, in various ways...
  75. doi Optical mapping and sequencing of the Escherichia coli KO11 genome reveal extensive chromosomal rearrangements, and multiple tandem copies of the Zymomonas mobilis pdc and adhB genes
    Peter C Turner
    Department of Microbiology and Cell Biology, University of Florida, Box 110700, Gainesville, FL 32611, USA
    J Ind Microbiol Biotechnol 39:629-39. 2012
    ..was engineered in 1990 to produce ethanol by chromosomal insertion of the Zymomonas mobilis pdc and adhB genes into E. coli W (ATCC 9637). KO11FL, our current laboratory version of KO11, and its parent E...
  76. pmc Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism
    Taro Hitosugi
    Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mol Cell 44:864-77. 2011
    ..1 (PDHK1), which phosphorylates and inactivates mitochondrial PDH and consequently pyruvate dehydrogenase complex (PDC). Here we report that tyrosine phosphorylation enhances PDHK1 kinase activity by promoting ATP and PDC binding...
  77. pmc A STATus report on DC development
    Haiyan S Li
    Department of Immunology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Leukoc Biol 92:445-59. 2012
    ..DCs constitute a heterogeneous population including plasmacytoid (pDC) and classic (cDC) subsets; however, the majority of DCs residing in lymphoid organs and peripheral tissues in ..
  78. pmc Pharmacological activation of the pyruvate dehydrogenase complex reduces statin-mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents
    Joanne E Mallinson
    MRC Arthritis Research UK Centre for Musculoskeletal Ageing Research, School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    J Physiol 590:6389-402. 2012
    ..We hypothesised that increasing CHO oxidation in vivo, using the pyruvate dehydrogenase complex (PDC) activator, dichloroacetate (DCA), would blunt activation of FOXO gene targets and reduce statin myopathy...
  79. pmc Activation, exhaustion, and persistent decline of the antimicrobial MR1-restricted MAIT-cell population in chronic HIV-1 infection
    Edwin Leeansyah
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Blood 121:1124-35. 2013
    Mucosal-associated invariant T (MAIT) cells are an evolutionarily conserved antimicrobial MR1-restricted T-cell subset. MAIT cells are CD161(+), express a V7.2 TCR, are primarily CD8(+) and numerous in blood and mucosal tissues...
  80. pmc miR-22 controls Irf8 mRNA abundance and murine dendritic cell development
    Haiyan S Li
    Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    PLoS ONE 7:e52341. 2012
    ..cells (DCs), an important immune cell type that is divided into conventional DC (cDC) and plasmacytoid DC (pDC) subsets...
  81. pmc Short-term effects of overnight orthokeratology on corneal epithelial permeability and biomechanical properties
    Thao N Yeh
    Clinical Research Center, School of Optometry, University of California Berkeley, Berkeley, CA, USA
    Invest Ophthalmol Vis Sci 54:3902-11. 2013
    To investigate the effects of 30 nights of overnight orthokeratology (OOK) on corneal epithelial permeability (Pdc) and corneal biomechanical properties.
  82. doi "Replica-extraction-transfer" nanostructure-initiator mass spectrometry imaging of acoustically printed bacteria
    Katherine B Louie
    Lawrence Berkeley National Laboratory, Berkeley, CA 94720, U S A
    Anal Chem 85:10856-62. 2013
    ..This approach is then used to analyze the metabolite composition of streaked Shewanella oneidensis MR1 and Pseudomonas stutzeri RCH2 colonies and further resolve complex patterns produced by acoustic printing of liquid ..
  83. doi Seminal PDC-109 protein vis-à-vis cholesterol content and freezability of buffalo spermatozoa
    Mahak Singh
    Division of Animal Reproduction, Indian Veterinary Research Institute, Izatnagar 243122, India
    Anim Reprod Sci 144:22-9. 2014
    ..One such protein, viz. PDC-109 is reported to influence freezability of spermatozoa in cattle...
  84. doi A novel regulatory mechanism based upon a dynamic core structure for the mitochondrial pyruvate dehydrogenase complex?
    Amanda K Broz
    Department of Biochemistry, University of Missouri, Columbia, MO, USA Electronic address
    Mitochondrion 19:144-53. 2014
    ..dihydrolipoamide acetyltransferase, the E2-component of the mitochondrial pyruvate dehydrogenase complex (PDC). Two genes encode E2-proteins with a single lipoyl domain, while the third has a two-lipoyl domain structure...
  85. pmc Analysis of gene expression and proteomic profiles of clonal genotypes from Theobroma cacao subjected to soil flooding
    Fabiana Z Bertolde
    Instituto Federal de Educação Ciência e Tecnologia, Campus Eunápolis, Eunápolis, Bahia, Brazil
    PLoS ONE 9:e108705. 2014
    ..pattern of genes associated with the biosynthesis of alcohol dehydrogenase (ADH), pyruvate decarboxylase (PDC) and lactate dehydrogenase (LDH) in leaves and roots of the two evaluated genotypes...
  86. pmc IL22 regulates human urothelial cell sensory and innate functions through modulation of the acetylcholine response, immunoregulatory cytokines and antimicrobial peptides: assessment of an in vitro model
    Phong T Le
    Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, United States of America
    PLoS ONE 9:e111375. 2014
    ..The cultured HUCs expressed muscarinic receptors (MR1 and MR2), carnitine acetyltransferase (CarAT), immunoregulatory cytokines IL7, IL15, and IL23, as well as the ..
  87. pmc Genetic analysis of the Warburg effect in yeast
    Bola Olayanju
    Department of Biochemistry and Molecular Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA
    Adv Biol Regul 57:185-92. 2015
    ..Specifically, mutations in the E1 subunit of either of two respiratory enzymes, pyruvate dehydrogenase (PDC) or α-ketoglutarate dehydrogenase (KGDC), change substrate specificity from the 3-carbon α-ketoacid pyruvate, or ..
  88. pmc Self-reactive IgE exacerbates interferon responses associated with autoimmunity
    Jill Henault
    Research Department, MedImmune, Gaithersburg, Maryland, USA
    Nat Immunol 17:196-203. 2016
    ..concentration of dsDNA-specific IgE found in patient serum correlated with disease severity and greatly potentiated pDC function by triggering phagocytosis via the high-affinity FcɛRI receptor for IgE, followed by Toll-like receptor 9 ..
  89. doi The immunomodulatory activities of pullulan and its derivatives in human pDC-like CAL-1 cell line
    Fang Wang
    Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Huanhuxi Road, Hexi District, Tianjin 300060, PR China Research Center of Basic Medical Science and School of Pharmacy, Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics Theranostics, Tianjin Medical University, No 22 Qixiangtai Road, Heping District, Tianjin 300070, PR China
    Int J Biol Macromol 86:764-71. 2016
    ..derivates were synthesized and their immunomodulatory activities compared to pullulan were investigated in human pDC-like CAL-1 cell line...
  90. pmc Molecular characterization of colorectal cancer patients and concomitant patient-derived tumor cell establishment
    Haa Na Song
    Department of Medicine, Division of Hematology Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Oncotarget 7:19610-9. 2016
    ..In parallel, we established collateral PDC models from the matched primary tumor tissues, which may be later used as preclinical models for genome-directed ..
  91. pmc Renoprotective Effect of Lactoferrin against Chromium-Induced Acute Kidney Injury in Rats: Involvement of IL-18 and IGF-1 Inhibition
    Rehab Hegazy
    Pharmacology Department, Medical Division, National Research Centre, Giza, Egypt
    PLoS ONE 11:e0151486. 2016
    ..present study investigated the potential renoprotective effect of lactoferrin (Lf) against potassium dichromate (PDC)-induced acute kidney injury (AKI) in rats...
  92. pmc MicroRNA-155 Mediates Augmented CD40 Expression in Bone Marrow Derived Plasmacytoid Dendritic Cells in Symptomatic Lupus-Prone NZB/W F1 Mice
    Sheng Yan
    Departments of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Int J Mol Sci 17:. 2016
    ..Overall, our results provide evidence for miR-155-mediated regulation in pDC functional abnormalities in SLE...
  93. doi Reciprocal Self-Assembly of Peptide-DNA Conjugates into a Programmable Sub-10-nm Supramolecular Deoxyribonucleoprotein
    Mahnseok Kye
    Department of Materials Science and Engineering, Yonsei University, 50 Yonsei ro, Seoul, 03722, Korea
    Angew Chem Int Ed Engl 55:12003-7. 2016
    ..Multicomponent systems, however, suffer from poor control of self-assembly behaviors. Covalently conjugated PDC building blocks are shown to assemble into well-defined and controllable nanostructures...
  94. pmc Transcriptional Repression of IFN Regulatory Factor 7 by MYC Is Critical for Type I IFN Production in Human Plasmacytoid Dendritic Cells
    Tae Whan Kim
    Baylor Institute for Immunology Research, Dallas, TX 75204 and
    J Immunol 197:3348-3359. 2016
    ..regulatory factor (IRF)7 is a critical regulator of type I IFN production when pathogens are detected by TLR 7/9 in pDC. However, hyperactivation of pDC can cause life-threatening autoimmune diseases...
  95. ncbi A gene outside the human MHC related to classical HLA class I genes
    K Hashimoto
    Institute for Comprehensive Medical Science, Fujita Health University, Aichi, Japan
    Science 269:693-5. 1995
    ..An expressed class I gene, MR1, has now been identified on human chromosome 1q25, outside the MHC...
  96. ncbi MR1-restricted Valpha19i T cells: a second population recognizing lipid antigens?
    Jens Schumann
    Experimental Immunology, Department of Research, University Hospital Basel, Basel, Switzerland
    Eur J Immunol 37:1724-6. 2007
    ..is known about the biology of another invariant T cell subset, which is restricted to the MHC class I-like molecule MR1. A beneficial role of MR1-restricted T cells has been suggested in a mouse EAE model...
  97. ncbi Magnetic resonance microscopy and immunohistochemistry of the CNS of the mutant SOD murine model of ALS reveals widespread neural deficits
    M S Petrik
    Program in Neuroscience, University of British Columbia, Vancouver, BC, Canada
    Neuromolecular Med 9:216-29. 2007
    ..over-expressing mice are similar to data previously obtained from a model of ALS-parkinsonism dementia complex (ALS-PDC), in which neural damage occurred following a diet of washed cycad flour containing various neurotoxins...
  98. doi Increased interferon alpha expression in circulating plasmacytoid dendritic cells of HIV-1-infected patients
    Clara Lehmann
    First Department of Internal Medicine, University of Cologne, Cologne, Germany
    J Acquir Immune Defic Syndr 48:522-30. 2008
    The role of plasmacytoid dendritic cells (pDC) and interferon alpha (IFN alpha) in HIV-1 infection is still unclear...
  99. doi Molecular characterization of human plasmacytoid dendritic cells
    Wei Cao
    Department of Immunology, Unit 901, 7455 Fannin, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Immunol 29:257-64. 2009
    ..It is clear now that pDC development is influenced by distinctive transcription factors that specify a unique lineage...
  100. doi Incisional hernia in action: the use of vacuum-assisted closure and porcine dermal collagen implant
    A E Canda
    Surgery Clinic, Manisa State Hospital, Manisa, Turkey
    Hernia 13:651-5. 2009
    ..we describe our experience in the successful use of vacuum-assisted closure (VAC) and porcine dermal collagen (PDC) mesh reconstruction of a complicated contaminated abdominal wall defect resulting from a strangulated incisional ..
  101. ncbi Paroxysmal dyskinesias
    Shyamal H Mehta
    Shyamal H Mehta, MD, PhD Movement Disorders Program, Department of Neurology, 1429 Harper Street, HF 1121, Augusta, GA 30912, USA
    Curr Treat Options Neurol 11:170-8. 2009
    ..been linked to the pericentromeric region of chromosome 16, PNKD is associated with mutations in the myofibrillogenesis regulator 1 (MR-1) gene on the long arm of chromosome 2 (2q32-36 locus), and PED is associated with mutations in ..

Research Grants72

  1. MERRILL E GERSHWIN; Fiscal Year: 2015
    ..AMAs), which react specifically with the lipoyl domain of the pyruvate dehydrogenase complex E2 subunit (PDC-E2)...
  2. STUART MICHAEL LEVITZ; Fiscal Year: 2016
    ..fumigatus-induced pDC death;2) following stimulation with A...
  3. Pathways regulating plasmacytoid dendritic cells in Peyers Patches
    Stephanie S Watowich; Fiscal Year: 2013
    ..The pDC developmental pathway proceeds through a common DC progenitor (CDP), which generates both pDCs and conventional DCs...
  4. HIV and Plasmacytoid dendritic cells in the thymus
    Christel Uittenbogaart; Fiscal Year: 2007
    Plasmacytoid dendritic cells (pDC) are lymphoid dendritic cells that express high levels of interleukin 3 (IL-3) receptor (CD 123) and produce type I interferons, cytokines with antiviral and immunoregulatory effects, pDC are present in ..
  5. Pedram Hamrah; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Plasmacytoid dendritic cells (pDC), a distinct type of bone marrow-derived cell, play an important role in linking innate and adaptive immune responses...
  6. Human Beta-Defensin-1 in HSV-1 Innate Immunity
    LISA KATHLEEN RYAN; Fiscal Year: 2010
    ..One type of DC, the plasmacytoid DC (PDC) is important in innate immune function through the production of interferon-? (IFN) induced by enveloped viruses ..
  7. Melissa Swiecki; Fiscal Year: 2014
    ..Plasmacytoid dendritic cells (pDC) have been identified as a major source of IFN-I in diabetic mouse models and an expansion of IFN-I-producing pDC ..
  8. Patricia Fitzgerald-Bocarsly; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Plasmacytoid dendritic cells (pDC) are the most potent type I interferon (IFN)- producing cells in the body and are considered to be the "professional IFN producing cells"...
  9. Boris Reizis; Fiscal Year: 2016
    ..Virus-induced IFN production by pDCs is critical for the control of viral infections, whereas aberrant pDC activation is associated with autoimmune diseases...
  10. Miriam Merad; Fiscal Year: 2016
    ..that are specialized in the cross-presentation of cell associated antigens to CD8+ T cells, and plasmacytoid DC (pDC), which help to establish an antiviral state through the rapid secretion of high amounts of interferon alpha...
  11. Yong Jun Liu; Fiscal Year: 2014
    ..The first aim will focus on the potential role of in CpG ODN trafficking by using a human pDC cell line with stable knockdown of PACSIN1 expression by shRNA and mouse pDCs derived from PACSIN-deficient mice...
  12. Plasmacytoid DC Interactions in the Generation of an Antitumor Immune Response
    Patrick Hwu; Fiscal Year: 2010
    ..In our preliminary studies, we found that activated, antigen-pulsed, pDC and mDC could individually stimulate antigen-specific CTL responses in mice...
  13. VIRIAN DAVY SEREI; Fiscal Year: 2014
    ..Plasmacytoid dendritic cells (pDC) are potent producers of type I interferons and are also known to express TRAIL during HIV infection...
  14. Effect of Atopy on Dendritic Cell Antiviral Responses
    Michelle A Gill; Fiscal Year: 2013
    ..Moreover, in vitro pDC IFN responses to virus are inhibited by IgE-dependent mechanisms...
  15. Nicholas W Lukacs; Fiscal Year: 2016
    ..To identify the differential role of chemokines for DC subset, pDC vs. cDC, trafficking to the lungs and activation leading to altered pulmonary responses...
  16. Kovit Pattanapanyasat; Fiscal Year: 2016
    ..with Fas-L expressing NK cells c) there is a marked increase in the frequencies of plamacytoid dendritic cells (pDC's) which express immature phenotype d) there is a muted memory B cell response against the heterologous dengue ..
  17. Meagan P O'Brien; Fiscal Year: 2015
    ..candidate's proposed research project centers on the idea that HIV dysregulates plasmacytoid dendritic cells (pDC) to activate deficient adaptive immune responses while stimulating persistent interferon-alpha (IFNa) production, ..
  18. Nina Bhardwaj; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Human plasmacytoid dendritic cells (pDC) constitute a rare subset of blood dendritic cells (DC), distinct from myeloid CD11c+, "conventional" DC (cDC)...
  19. The Role of Type III Interferon in Innate Immunity to Respiratory Virus Infection
    Joan E Durbin; Fiscal Year: 2010
    ..3) Characterize production of, and responsiveness to, type I and type III IFNs by polarized airway epithelial cells. 4) Determine the role of IFN-lambda in pDC maturation and function during influenza virus infection.
  20. Melissa Victoria Fernandez; Fiscal Year: 2014
    ABSTRACT Human plasmacytoid dendritic cells (pDC) constitute a rare subset of blood dendritic cells (DC), distinct from myeloid CD11c+, [unreadable]conventional[unreadable] DC (cDC)...
  21. HARRY BERNARD GREENBERG; Fiscal Year: 2014
    ..the interaction of murine plasmacytoid dendritic cells (pDCs) with RV and determine the contribution of pDC-derived interferon to restricting RV infection...
  22. Mark A Atkinson; Fiscal Year: 2016
    ..defects in type 1 IFN biology, hyperactive IFN[unreadable]/[unreadable] responses and increased plasmacytoid DC (PDC)/IFN[unreadable]/[unreadable] production in the islet microenvironment play a critical role in T1D pathogenesis...
  23. Akiko Iwasaki; Fiscal Year: 2014
    ..In professional viral sensors, the plasmacytoid dendritic cells (pDC), recognition of viruses occurs in the endosomes via Toll-like receptors (TLR) 7 and 9...
  24. Dissecting Dendritic Cell Function in Autoimmune Diabetes
    JONATHAN DAVID KATZ; Fiscal Year: 2013
    ..Conversely, depleting plasmacytoid DC (pDC) exacerbates the pathology- increasing both the number and severity of infiltrated islets, suggesting that, once ..
  25. AAV-Based Plasmacytoid Dendritic Cell Cancer Vaccine
    Pierre L Triozzi; Fiscal Year: 2010
    ..There is experimental evidence suggesting that the plasmacytoid DC subpopulation (pDC) plays an important role in regulating the T-helper (Th) polarization of the immune response...
  26. David H Munn; Fiscal Year: 2016
    ..murine models have: (i) elucidated the identity of the novel subset of plasmacytoid dendritic cell (pDC) in tumor-draining lymph nodes that express IDO;(ii) identified the downstream molecular pathway in T cells by ..
  27. Migration and Trafficking in Tolerance 10/07
    Jonathan S Bromberg; Fiscal Year: 2012
    ..now demonstrate that during tolerization there is alloantigen specific clustering of T cells and plasmacytoid DC (pDC) in the T cell areas of the lymph node (LN) near the abluminal surface of the high endothelial venules (HEV)...
  28. A Novel Tolergenic Dendritic Cell: Biology &Therapeutic Potential
    Eugene C Butcher; Fiscal Year: 2013
    ..Preliminary studies show that CCR9+ DCs are a subset of immature plasmacytoid DC (pDC), and have provided initial insights leading to the following general hypotheses: 1...
  29. Gyongyi Szabo; Fiscal Year: 2016
    ..We hypothesize that HCV-mediated signals play a role in HCV-induced alterations in dendritic cells (mDCI, mDC2, pDC) and contribute to the reduced T cell responses in HCV infection by induction of CD4+CD25+ regulatory T cells...
  30. Jonathan S Bromberg; Fiscal Year: 2016
    ..where they are stimulated in the cortical area by specific alloantigen presenting plasmacytoid dendritic cells (pDC) to generate adaptive or induced Treg (aTreg)...
  31. Qing Yi; Fiscal Year: 2016
    ..However, several recent studies have also identified pDC as critical players in oral and airway tolerance...
  32. Audrey H Lau; Fiscal Year: 2014
    ..It has been hypothesized that immature pDC are inherently tolerogenic...
  33. HEATHER WINONA STOUT-DELGADO; Fiscal Year: 2015
    ..The goal of this proposal is to examine the effects of chronic viral infection on pDC cell function and how these effects contribute to viral persistence and susceptibility to a secondary infection...
  34. Activation of Plasmacytoid Dendritic Cells (pDCs) to Induce Antitumor Activity
    Patrick Hwu; Fiscal Year: 2012
    ..In Project 2, further characterization of pDC interactions will be performed in a murine tumor model...
  35. Role of dendritic cells in resistance to Toxoplasma.
    Christopher A Hunter; Fiscal Year: 2010
    ..Unexpectedly, parallel work identified plasmacytoid DC (pDC), a newly described DC subset, as a prominent cell type involved in the development of T helper cell responses to ..
  36. Role of plasmacytoid dendritic cells in human metapneumo virus infection
    MARIA ANTONIETA GUERRERO-PLATA; Fiscal Year: 2011
    ..Based on preliminary data from our group, we will test the hypothesis that lung plasmacytoid dendritic cells (pDC), critical immune cells in mediating antiviral response, play a major role in controlling hMPV-induced lung ..
  37. Donald D Anthony; Fiscal Year: 2016
    ..Plasmacytoid dendritic cells (pDC) produce IFN-alpha during viral infection, and directly activate NK cells...
  38. Role of Peripheral Dendritic Cells in Central and Oral Tolerance
    Husein Hadeiba; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): We have identified a potent tolerogenic plasmacytoid dendritic cell (pDC) population defined by expression of the chemokine receptor CCR9, and have shown that these CCR9+ pDCs not only induce ..
  39. Role of IL28B and HIV in NK Control of HCV
    Donald D Anthony; Fiscal Year: 2013
    ..Plasmacytoid dendritic cells (pDC) produce IFN-a during viral infection, and directly activate NK cells...
  40. GREGORY MULLOKANDOV; Fiscal Year: 2016
    ..Plasmacytoid DC (pDC) is a major subset of DCs and are one of the earliest defenses of the body against specific pathogens...
  41. IFN-a and pDC in HIV infection: impact on T cell development and reconstitution
    Christel H Uittenbogaart; Fiscal Year: 2013
    ..In addition we found that in normal thymus tissue, mature thymocytes and plasmacytoid dendritic cells (pDC) constitutively express IFN-?? and its secondary response protein MxA at low levels...
  42. Cellular innate activation as a tactic to prevent HIV-1 transmission
    LUIS J contact MONTANER; Fiscal Year: 2010
    ..We will collect both direct and indirect correlative data to test the hypothesis that plasmacytoid dendritic cells (pDC) recruitment and activation into the cervicovaginal compartment by HIV-1 particles or infected cells not resulting ..
  43. Yong Jun Liu; Fiscal Year: 2014
    ..Knocking down DHX36 expression by siRNA in a pDC cell line was associated with over 50% reduction in type 1 IFN responses and abolished IRF7 nuclear translocation ..
  44. Hans Christian Reinecker; Fiscal Year: 2016
    ..We have identified a mucosal plasmacytoid dendritic cell (pDC) subset that has a critical role in limiting intestinal inflammation thereby promoting tissue reconstruction and ..
  45. Pyruvate Dehydrogenase kinase as Therapeutic Target for Hepatic Steatosis, Obesit
    Robert A Harris; Fiscal Year: 2012
    ..The activity of the pyruvate dehydrogenase complex (PDC) is tightly regulated by phosphorylation by the PDKs...
  46. William M Ridgway; Fiscal Year: 2015
    ..ABD" mice) that develop spontaneous, autoimmune biliary disease (ABD) and anti-pyruvate dehydrogenase complex (PDC) autoantibodies, and serve as a model of human primary biliary cirrhosis (PBC)...
  47. Retrovirus Isolation from Primary Biliary Cirrhosis
    Andrew Mason; Fiscal Year: 2004
    ..of patients develop anti-mitochondrial antibodies (AMA) reactive to pyruvate dehydrogenase complex E2 component (PDC-E2), which is aberrantly expressed on cell surface of biliary epithelial cells of patients with PBC...
  48. CHARACTERIZATION OF A NEW FAMILY OF PROTEIN KINASES
    Kirill M Popov; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The reaction catalyzed by mitochondrial pyruvate dehydrogenase complex (PDC) links glycolysis and Citric Acid Cycle...
  49. DAVID BENNER LOMBARD; Fiscal Year: 2016
    ..plays a hitherto undescribed role in deacetylating and suppressing activity of Pyruvate Dehydrogenase Complex (PDC), a mitochondrial holoenzyme with a major role in regulating glucose oxidation in mammalian cells...
  50. Diabetic Cardiomyopathy
    Wolfgang H Dillmann; Fiscal Year: 2011
    ..Studies of Aim III are directed at increasing the activity of the pyruvate dehydrogenase complex (PDC) of the D heart and enhancing glucose oxidation (ox)...
  51. Regulation of Energy Metabolism by PDP1 and PDP2
    Kirill M Popov; Fiscal Year: 2012
    ..understand the molecular mechanisms responsible for the regulation of mitochondrial pyruvate dehydrogenase complex (PDC)...
  52. INBORN ERRORS OF METABOLISM IN CELL CULTURE
    David T Chuang; Fiscal Year: 2010
    ..comprises the branched-chain alpha-ketoacid dehydrogenase complex (BCKDC), the pyruvate dehydrogenase complex (PDC) and the alpha-ketoglutarate dehydrogenase complex (KGDC)...
  53. INBORN ERRORS OF PYRUVATE METABOLISM
    Mulchand Patel; Fiscal Year: 1999
    The pyruvate dehydrogenase complex (PDC) plays a pivotal role in the metabolism of pyruvate for energy production and for biosynthetic processes...
  54. VOLATILE ACID FORMATION IN PARASITIC HELMINTHS
    Richard Komuniecki; Fiscal Year: 2004
    ..novel anaerobic mitochondria present in the parasitic nematode, Ascaris suum: The pyruvate dehydrogenase complex (PDC) plays a key role in regulating these anaerobic mitochondrial pathways and its regulation and subunit composition ..
  55. INBORN ERRORS OF THE PYRUVATE DEHYDROGENASE COMPLEX
    Isaiah Wexler; Fiscal Year: 1993
    The aim of the proposed project is to identify and analyze mutations responsible for pyruvate dehydrogenase complex (PDC) deficiency, an inherited disorder of energy metabolism which causes lactic acidosis and neurologic disability...
  56. Immune response to Pneumocystis and bone marrow failure
    Nicole Meissner; Fiscal Year: 2013
    ..occurs due to the loss of CD4 T cells and type I interferon (type-I-IFN) producing plasmacytoid dendritic cell (pDC). These infections contribute greatly to morbidity and mortality...
  57. Argyrios N Theofilopoulos; Fiscal Year: 2014
    ..Among the innate immune cells implicated in the pathogenesis of lupus is the plasmacytoid dendritic cell (pDC) which constitute a small (<1%), but distinct population of cells that is thought to be activated by nucleic ..
  58. DANIEL ROBERT GOLDSTEIN; Fiscal Year: 2016
    ..by using murine models to determine 1) if exaggerated inflammatory responses by NKT cells coupled to defective pDC responses are critical for the generation of IL-17 anti-viral CD4+ T cells during systemic herpes viral infections ..
  59. Eugene C Butcher; Fiscal Year: 2016
    ..progenitors of intestinal DC populations including CD103+ cDC;and they can also give rise to CCR9+ plasmacytoid DC (pDC)...
  60. MERRILL E GERSHWIN; Fiscal Year: 2016
    ..by breach of tolerance to the major mitochondrial autoantigen, the E2 component of pyruvate dehydrogenase (PDC-E2)...
  61. David W Speicher; Fiscal Year: 2014
    ..The effects of drug use on NK or PDC activation programs, even in the absence of repeated HIV exposure, are also unknown...
  62. MECHANISMS AND PATHOGENESIS OF PRIMARY BILIARY CIRRHOSIS
    MERRILL E GERSHWIN; Fiscal Year: 2010
    ..at the apical surface of BECs, which reacts with autoantibodies specific for the major mitochondrial autoantigens, PDC-E2, BCOADC-E2, and OGDC-E2. Such localization prompts us to propose three specific issues...
  63. HIV and Plasmacytoid dendritic cells in the thymus
    Christel Uittenbogaart; Fiscal Year: 2002
    Plasmacytoid dendritic cells (pDC) or natural interferon type I producing cells play an important role in linking innate and acquired immunity...
  64. REGULATION OF MAMMALIAN PYRUVATE DEHYDROGENASE
    THOMAS ROCHE; Fiscal Year: 2004
    The mammalian pyruvate dehydrogenase complex (PDC) connects glycolysis to oxidative metabolism and fatty acid synthesis with the irretrievable loss of glucose carbons...
  65. REGULATION OF MAMMALIAN DIHYDROLIPOAMIDE DEHYDROGENASE
    Mulchand Patel; Fiscal Year: 2002
    ..In eukaryotic pyruvate dehydrogenase complex (PDC), E3 binds to an E3-binding protein (E3BP)...
  66. 3D ELECTRON MICROSCOPY OF PYRUVATE DEHYDROGENASE
    JAMES STOOPS; Fiscal Year: 2002
    ..Mammalian pyruvate dehydrogenase complex (PDC) plays a critical role in regulating cellular fuel utilization in the heart and, therefore, studies of the ..
  67. 3D ELECTRON MICROSCOPY OF PYRUVATE DEHYDROGENASE
    JAMES STOOPS; Fiscal Year: 2001
    ..Mammalian pyruvate dehydrogenase complex (PDC) plays a critical role in regulating cellular fuel utilization in the heart and, therefore, studies of the ..
  68. GENETIC ANALYSIS OF PAROXYSMAL DYSTONIC CHOREOATHETOSIS
    John Fink; Fiscal Year: 2000
    ..The principal investigator proposes to study paroxysmal dystonic choreoathetosis (PDC), an inherited disorder characterized by attacks of involuntary movements that occur spontaneously at rest and ..
  69. Targeting pDCs for the Generation of Effective Anti-HCV CD8+ T-Cell Immunity
    John Connolly; Fiscal Year: 2009
    ..Furthermore we have demonstrated that targeting antigens to this compartment in an activated pDC is sufficient to initiate potent CD8+ T-cell responses...
  70. XENOBIOTICS AND PRIMARY BILIARY CIRRHOSIS
    MERRILL GERSHWIN; Fiscal Year: 2001
    ..AMAs are directed at the E2 components of the 2-oxo acid dehydrogenase pathway, particularly PDC-E2; 95 percent of patients with PBC have a positive AMA...
  71. A Revolutionary Therapy for Atherosclerosis: Liquid Cast Arterial Stents
    Guillermo A Ameer; Fiscal Year: 2010
    ..We will use a biocompatible elastomeric citric acid-based polymer, polydiolcitrate (PDC) that will be diazeniumdiolated to spontaneously release nitric oxide (NO) when placed in the circulation...
  72. Phytoestrogen and Antioxidant Regulation of Prostate Cancer
    Dennis Lubahn; Fiscal Year: 2009
    ..Exciting data from our model clearly show that ERalphaKO mice are highly protected against PDC (poorly differentiated carcinoma) of the prostate and ERbetaKO mice are highly susceptible to PDC...