PLCE1

Summary

Gene Symbol: PLCE1
Description: phospholipase C epsilon 1
Alias: NPHS3, PLCE, PPLC, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1, PLC-epsilon-1, pancreas-enriched phospholipase C, phosphoinositide phospholipase C, phosphoinositide phospholipase C-epsilon-1, phosphoinositide-specific phospholipase C epsilon-1
Species: human

Top Publications

  1. ncbi Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line
    G Zauli
    Institute of Human Anatomy, University of Ferrara, Italy
    Eur J Immunol 25:2695-700. 1995
  2. doi Mutations in phospholipase C epsilon 1 are not sufficient to cause diffuse mesangial sclerosis
    Rodney D Gilbert
    Wessex Regional Paediatric Nephro Urology Service, Southampton General Hospital, Southampton, UK
    Kidney Int 75:415-9. 2009
  3. pmc Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway
    D Cefai
    Laboratoire d Immunologie Cellulaire et Tissulaire, Group Hospitalier GH Pitié Salpétrière, Paris, France
    J Clin Invest 86:2117-24. 1990
  4. ncbi Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat
    N J Haughey
    Department of Pharmacology and Therapeutics, University of Manitoba Faculty of Medicine, Winnipeg, Canada
    J Neurochem 73:1363-74. 1999
  5. doi Replication study of PLCE1 and C20orf54 polymorphism and risk of esophageal cancer in a Chinese population
    Haiyong Gu
    Department of Cardiothorac Surgery, Affiliated People s Hospital of Jiangsu University, Zhenjiang 212000, China
    Mol Biol Rep 39:9105-11. 2012
  6. doi Phospholipase C epsilon plays a suppressive role in incidence of colorectal cancer
    Xiaoliang Wang
    Department of General Surgery, Shanghai First People s Hospital, School of Medicine, Shanghai Jiao Tong University, 100, Haining Road, Shanghai 200080, China
    Med Oncol 29:1051-8. 2012
  7. ncbi Screening of new tumor suppressor genes in sporadic colorectal cancer patients
    Xiaoliang Wang
    Department of General Surgery, Shanghai Jiao Tong University Affiliated First People s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China
    Hepatogastroenterology 55:2039-44. 2008
  8. doi RNA interference suppressing PLCE1 gene expression decreases invasive power of human bladder cancer T24 cell line
    Liping Ou
    Department of Laboratory Diagnosis, Chongqing Medical University, Chongqing, CQ, China
    Cancer Genet Cytogenet 200:110-9. 2010
  9. pmc A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma
    Christian C Abnet
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Nat Genet 42:764-7. 2010
  10. doi Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54
    Li Dong Wang
    Cancer Research Center, Xinxiang Medical University, Xinxiang, Henan, China
    Nat Genet 42:759-63. 2010

Research Grants

  1. Exon capture and large-scale sequencing for disease-cause identification, early d
    Friedhelm Hildebrandt; Fiscal Year: 2010
  2. Friedhelm Hildebrandt; Fiscal Year: 2016
  3. Chung Owyang; Fiscal Year: 2016
  4. Chung Owyang; Fiscal Year: 2015
  5. Alan V Smrcka; Fiscal Year: 2016
  6. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    ANASTACIA BERZAT; Fiscal Year: 2005

Scientific Experts

Detail Information

Publications92

  1. ncbi Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line
    G Zauli
    Institute of Human Anatomy, University of Ferrara, Italy
    Eur J Immunol 25:2695-700. 1995
    ..The relevance of these findings for a better understanding of the biological functions of extracellular Tat is discussed...
  2. doi Mutations in phospholipase C epsilon 1 are not sufficient to cause diffuse mesangial sclerosis
    Rodney D Gilbert
    Wessex Regional Paediatric Nephro Urology Service, Southampton General Hospital, Southampton, UK
    Kidney Int 75:415-9. 2009
    ..Recently, mutations in phospholipase C epsilon 1 (PLCE1) were found to cause a nonsyndromic, autosomal recessive form of this disease...
  3. pmc Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway
    D Cefai
    Laboratoire d Immunologie Cellulaire et Tissulaire, Group Hospitalier GH Pitié Salpétrière, Paris, France
    J Clin Invest 86:2117-24. 1990
    ....
  4. ncbi Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat
    N J Haughey
    Department of Pharmacology and Therapeutics, University of Manitoba Faculty of Medicine, Winnipeg, Canada
    J Neurochem 73:1363-74. 1999
    ....
  5. doi Replication study of PLCE1 and C20orf54 polymorphism and risk of esophageal cancer in a Chinese population
    Haiyong Gu
    Department of Cardiothorac Surgery, Affiliated People s Hospital of Jiangsu University, Zhenjiang 212000, China
    Mol Biol Rep 39:9105-11. 2012
    ..association studies (GWAS) reported that functional genetic variations in the phospholipase C epsilon gene (PLCE1) were strongly associated with risk of esophageal squamous cell carcinoma (ESCC) and gastric cardia adenocarcinoma ..
  6. doi Phospholipase C epsilon plays a suppressive role in incidence of colorectal cancer
    Xiaoliang Wang
    Department of General Surgery, Shanghai First People s Hospital, School of Medicine, Shanghai Jiao Tong University, 100, Haining Road, Shanghai 200080, China
    Med Oncol 29:1051-8. 2012
    In our previous study, we have found that PLCE1 was down-regulated in sporadic colorectal cancer. But the role of PLCE1 in the incidence of colorectal cancer is still not definite...
  7. ncbi Screening of new tumor suppressor genes in sporadic colorectal cancer patients
    Xiaoliang Wang
    Department of General Surgery, Shanghai Jiao Tong University Affiliated First People s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China
    Hepatogastroenterology 55:2039-44. 2008
    ..The purpose of this study was to screen for unknown tumor suppressor genes (TSGs) in patients with sporadic CRC...
  8. doi RNA interference suppressing PLCE1 gene expression decreases invasive power of human bladder cancer T24 cell line
    Liping Ou
    Department of Laboratory Diagnosis, Chongqing Medical University, Chongqing, CQ, China
    Cancer Genet Cytogenet 200:110-9. 2010
    Mutational activation of the ras proto-oncogenes is frequently found in cancers. The phospholipase C epsilon gene (PLCE1) encodes a novel ras-related protein (R-Ras) effector mediating the effects of R-Ras on the actin cytoskeleton and ..
  9. pmc A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma
    Christian C Abnet
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Nat Genet 42:764-7. 2010
    ..A notable signal was rs2274223, a nonsynonymous SNP located in PLCE1, for gastric cancer (P = 8.40 x 10(-9); per-allele odds ratio (OR) = 1.31) and ESCC (P = 3.85 x 10(-9); OR = 1.34)...
  10. doi Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54
    Li Dong Wang
    Cancer Research Center, Xinxiang Medical University, Xinxiang, Henan, China
    Nat Genet 42:759-63. 2010
    ..We identified two previously unknown susceptibility loci for ESCC: PLCE1 at 10q23 (P(Han combined for ESCC) = 7.46 x 10(-56), odds ratio (OR) = 1.43; P(Uygur-Kazakh for ESCC) = 5...
  11. doi Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations
    Chen Wu
    State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Nat Genet 43:679-84. 2011
    ..92 × 10(-56)). These findings highlight the involvement of multiple genetic loci and gene-environment interaction in the development of esophageal cancer...
  12. pmc Association between novel PLCE1 variants identified in published esophageal cancer genome-wide association studies and risk of squamous cell carcinoma of the head and neck
    Hongxia Ma
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    BMC Cancer 11:258. 2011
    Phospholipase C epsilon 1 (PLCE1) (an effector of Ras) belonging to the phospholipase family plays crucial roles in carcinogenesis and progression of several cancers, including squamous cell carcinoma of the head and neck (SCCHN)...
  13. doi Genetic variation in PLCE1 is associated with gastric cancer survival in a Chinese population
    Dewei Luo
    Department of Molecular and Genetic Toxicology, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, School of Public Health, Nanjing Medical University, Nanjing 210029, China
    J Gastroenterol 46:1260-6. 2011
    ..genome-wide association studies on gastric cancer showed a previously unknown gastric cancer susceptible locus in PLCE1 at 10q23...
  14. pmc Phospholipase C isozymes are deregulated in colorectal cancer--insights gained from gene set enrichment analysis of the transcriptome
    Stine A Danielsen
    Department of Cancer Prevention, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway
    PLoS ONE 6:e24419. 2011
    ..several members of the Phospholipase C protein family, and the reduced expression of two of these, PLCD1 and PLCE1, were successfully validated in CRC biopsies (n = 70) and cell lines (n = 19) by quantitative analyses...
  15. pmc Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1
    Chiea Chuen Khor
    Infectious Diseases, Genome Institute of Singapore, Singapore
    Nat Genet 43:1139-41. 2011
    ..34 (95% confidence interval: 1.23-1.46)). We identified associated variants within PLCE1 (phospholipase C, epsilon 1) on chromosome 10 (rs3765524, P(meta) = 3.08 × 10(-10), per-allele OR = 0...
  16. doi Putatively functional PLCE1 variants and susceptibility to esophageal squamous cell carcinoma (ESCC): a case-control study in eastern Chinese populations
    Haichuan Hu
    Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China
    Ann Surg Oncol 19:2403-10. 2012
    A novel variant rs2274223 located in the phospholipase C epsilon 1 (PLCE1) gene was found to be associated with risk of esophageal squamous cell carcinoma (ESCC) by 2 large-scale genome-wide association studies (GWASs) in Chinese ..
  17. pmc Potentially functional variants of PLCE1 identified by GWASs contribute to gastric adenocarcinoma susceptibility in an eastern Chinese population
    Mengyun Wang
    Cancer Research Laboratory, Fudan University Shanghai Cancer Center, Shanghai, China
    PLoS ONE 7:e31932. 2012
    ..Recent genome-wide association studies (GWAS) have found a single nucleotide polymorphism (SNP, rs2274223 A>G) in PLCE1 to be associated with risk of gastric adenocarcinoma...
  18. ncbi Phospholipase C epsilon 1 (PLCE1 rs2274223A>G, rs3765524C>T and rs7922612C>T) polymorphisms and esophageal cancer risk in the Kashmir Valley
    Manzoor Ahmad Malik
    Department of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India E mail
    Asian Pac J Cancer Prev 15:4319-23. 2014
    Phospholipase C epsilon 1 (PLCE1) encodes a member of the phospholipase family of proteins that play crucial roles in carcinogenesis and progression of several cancers including esophageal cancer (EC)...
  19. pmc Genetic variation in C20orf54, PLCE1 and MUC1 and the risk of upper gastrointestinal cancers in Caucasian populations
    Andrew J Palmer
    GI Reseach Group, University of Aberdeen, Aberdeen, Scotland
    Eur J Cancer Prev 21:541-4. 2012
    ..associations between upper gastrointestinal cancer and the rs2274223, rs13042395 and rs4072037 polymorphisms in PLCE1, C20orf54 and MUC1, respectively...
  20. pmc Distinct genetic association at the PLCE1 locus with oesophageal squamous cell carcinoma in the South African population
    Hannah Bye
    Department of Medical and Molecular Genetics, King s College London, King s Health Partners, Guy s Hospital, London, United Kingdom
    Carcinogenesis 33:2155-61. 2012
    ..association studies in Chinese populations identified five new OSCC susceptibility loci, including variants at PLCE1, C20orf54, PDE4D, RUNX1 and UNC5CL, but their contribution to disease risk in other populations is unknown...
  21. doi PLC-ε1 gene polymorphisms significantly enhance the risk of esophageal squamous cell carcinoma in individuals with a family history of upper gastrointestinal cancers
    Rong Miao Zhou
    Department of Molecular Biology, the Fourth Affiliated Hospital of Hebei Medical University, Hebei Province, China
    Arch Med Res 43:578-84. 2012
    ....
  22. doi GWAS-uncovered SNPs in PLCE1 and RFT2 genes are not implicated in Dutch esophageal adenocarcinoma and squamous cell carcinoma etiology
    Polat Dura
    Department of Gastroenterology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Eur J Cancer Prev 22:417-9. 2013
    ..The total EC group included 86 patients with ESCC and 258 patients with EAC. The distribution of PLCE1 and RFT2 genotypes did not differ between patients with EAC or ESSC, and the controls...
  23. pmc Genetic variants of MICB and PLCE1 and associations with non-severe dengue
    James Whitehorn
    Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 8:e59067. 2013
    ..association study (GWAS) identified susceptibility loci for dengue shock syndrome (DSS) at MICB rs3132468 and PLCE1 rs3740360...
  24. doi Novel functional variants locus in PLCE1 and susceptibility to esophageal squamous cell carcinoma: based on published genome-wide association studies in a central Chinese population
    Fujiao Duan
    Department of Epidemiology and Statistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, PR China
    Cancer Epidemiol 37:647-52. 2013
    A novel functional single nucleotide polymorphism (SNP) rs2274223 located in the phospholipase C epsilon 1 (PLCE1) gene was found to be associated with the risk of esophageal squamous cell carcinoma (ESCC) by three large-scale genome-..
  25. pmc PLCE1 polymorphism and upper gastrointestinal cancer risk: a meta-analysis
    Ning Bo Hao
    Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing, China
    PLoS ONE 8:e67229. 2013
    In recent years, the PLCE1 rs2274223 polymorphism has been extensively investigated as a potential risk factor for upper gastrointestinal cancers, including squamous cell carcinoma (ESCC) and gastric cancer...
  26. pmc Esophageal squamous cell carcinoma and gastric cardia adenocarcinoma shared susceptibility locus in PLCE1: a meta-analysis
    Ruiqin Mai
    Department of Laboratory Medicine, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China
    PLoS ONE 8:e69214. 2013
    Two recent genome-wide association studies have identified a shared susceptibility variation PLCE1 rs2274223 for esophageal squamous cell carcinoma (ESCC) and gastric cardia adenocarcinomas (GCA)...
  27. doi Association of potentially functional genetic variants of PLCE1 with gallbladder cancer susceptibility in north Indian population
    Kiran Lata Sharma
    Department of Genetics, SGPGIMS, Lucknow, 226014, Uttar Pradesh, India
    J Gastrointest Cancer 44:436-43. 2013
    Phospholipase C epsilon 1 (PLCE1) plays crucial roles in carcinogenesis and progression of esophageal and gastric cancers. In the present study, we investigated association of GWAS identified rs2274223 A>G and...
  28. pmc Increased risk of developing digestive tract cancer in subjects carrying the PLCE1 rs2274223 A>G polymorphism: evidence from a meta-analysis
    Xunlei Zhang
    Department of Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China
    PLoS ONE 8:e76425. 2013
    To date, the association between phospholipase C epsilon 1 (PLCE1) rs2274223 A>G and risk of digestive tract cancer (DTC) remains inconclusive...
  29. doi Common genetic variants at 1q22 and 10q23 and gastric cancer susceptibility in a Korean population
    Hye Rim Song
    Department of Preventive Medicine, Chonnam National University Medical School, 5, Hak 1 dong, Dong Gu, Gwangju, 501 746, South Korea
    Tumour Biol 35:3133-7. 2014
    ..The aim of this study was to determine whether rs4072037A > G in MUC1 at 1q22 and rs2274223A > G in PLCE1 at 10q23 are associated with a risk of gastric cancer in a Korean population...
  30. doi Association between phospholipase C epsilon gene (PLCE1) polymorphism and colorectal cancer risk in a Chinese population
    Qi Wang
    Sir Run Run Shaw Institute of Clinical Medicine of Zhejiang University, Hangzhou, Zhejiang Province, China
    J Int Med Res 42:270-81. 2014
    To investigate the association between a single nucleotide polymorphism rs2274223 (adenine [A] to guanine [G]) in the phospholipase C epsilon 1 (PLCE1) gene and susceptibility to colorectal cancer (CRC).
  31. doi Meta-analysis of phospholipase C epsilon 1 polymorphism and cancer risk
    Yu Zhang
    Institute of Stomatology, Nanjing Medical University, Nanjing, China
    Cancer Biomark 13:483-9. 2013
    Phospholipase C epsilon 1 (PLCE1) plays crucial roles in carcinogenesis and progression of several cancers. A single nucleotide polymorphism (SNP, rs2274223) in PLCE1 has been identified as a novel susceptibility locus.
  32. ncbi Structural and mechanistic insights into ras association domains of phospholipase C epsilon
    Tom D Bunney
    Cancer Research UK Centre for Cell and Molecular Biology, Chester Beatty Laboratories, The Institute of Cancer Research, Fulham Road, London SW3 6JB, United Kingdom
    Mol Cell 21:495-507. 2006
    ..Studies of PLCepsilon regulation suggest that, in a cellular context, the RA2 domain, in a mode specific to PLCepsilon, has a role in membrane targeting with further regulatory impact on PLC activity...
  33. ncbi Phospholipase C epsilon modulates beta-adrenergic receptor-dependent cardiac contraction and inhibits cardiac hypertrophy
    Huan Wang
    Department of Pharmacology and Physiology, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Circ Res 97:1305-13. 2005
    ....
  34. ncbi Signaling properties and expression in normal and tumor tissues of two phospholipase C epsilon splice variants
    Sonia Caroline Sorli
    Cancer Research UK Centre for Cell and Molecular Biology, Chester Beatty Laboratories, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK
    Oncogene 24:90-100. 2005
    ..Taken together, our findings suggest that regulatory mechanisms controlling expression of PLCepsilon, broadened by diversity introduced by splice variants, could play important role in PLCepsilon regulation in normal and tumor cells...
  35. ncbi Hyaluronan-CD44 interaction with leukemia-associated RhoGEF and epidermal growth factor receptor promotes Rho/Ras co-activation, phospholipase C epsilon-Ca2+ signaling, and cytoskeleton modification in head and neck squamous cell carcinoma cells
    Lilly Y W Bourguignon
    Department of Medicine, University of California at San Francisco and Endocrine Unit 111N, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Biol Chem 281:14026-40. 2006
    ....
  36. ncbi Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible
    Bernward Hinkes
    Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Genet 38:1397-405. 2006
    ..Using positional cloning, we identified mutations in the phospholipase C epsilon gene (PLCE1) as causing early-onset nephrotic syndrome with end-stage kidney disease...
  37. ncbi Familial nephrotic syndrome: PLCE1 enters the fray
    Jonathan Ashley Jefferson
    Division of Nephrology, University of Washington, 1959 NE Pacific Street, Box 356521, Seattle, Washington 98195, USA
    Nephrol Dial Transplant 22:1849-52. 2007
  38. ncbi Mutations in PLCE1 are a major cause of isolated diffuse mesangial sclerosis (IDMS)
    Rasheed Gbadegesin
    Departments of Pediatrics and of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    Nephrol Dial Transplant 23:1291-7. 2008
    ..We recently identified by positional cloning recessive mutations in the gene PLCE1/NPHS3 as a novel cause of IDMS. We demonstrated a role of PLCE1 in glomerulogenesis...
  39. ncbi Role of the CDC25 homology domain of phospholipase Cepsilon in amplification of Rap1-dependent signaling
    T G Jin
    Division of Molecular Biology, Department of Molecular and Cellular Biology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Biol Chem 276:30301-7. 2001
    ..These results suggest a pivotal role of the CDC25 homology domain in amplifying Rap1-dependent signal transduction, including the activation of PLCepsilon itself, at specific subcellular locations such as the Golgi apparatus...
  40. ncbi A novel bifunctional phospholipase c that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway
    I Lopez
    Department of Pathology and Feinberg Cardiovascular Research Institute, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Biol Chem 276:2758-65. 2001
    ..Our findings demonstrate that PLCepsilon is a novel bifunctional enzyme that is regulated by the heterotrimeric G protein Galpha(12) and activates the small G protein Ras/mitogen-activated protein kinase signaling pathway...
  41. ncbi Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras
    C Song
    Department of Physiology II, Kobe University School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Biol Chem 276:2752-7. 2001
    ..These results indicate that Ras directly regulates phosphoinositide breakdown through membrane targeting of PLCepsilon...
  42. pmc PLCE1 Promotes Esophageal Cancer Cell Progression by Maintaining the Transcriptional Activity of Snail
    Shicong Zhai
    Center for Cancer Research, Xinxiang Medical University, Xinxiang, Henan, China Department of Gastroenterology, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, China
    Neoplasia 19:154-164. 2017
    ..Multiple studies with large clinic-based cohorts revealed that variations of the phospholipase C epsilon (PLCE1) gene were associated with esophageal cancer susceptibility...
  43. doi Genetic association of PLCE1, C11orf92-C11orf93, and NOC3L with colorectal cancer risk in the Han population
    Xianglong Duan
    School of Life Sciences, Northwest University, Xi an, 710069, China
    Tumour Biol 35:1813-7. 2014
    ..Based on χ(2) tests, PLCE1 -rs2077218, rs11187877 (p = 0.049) and C11orf92-C11orf93-rs3802842 (p = 0.023) correlate with CRC risk...
  44. doi Replication of results of genome-wide association studies on esophageal squamous cell carcinoma susceptibility loci in a Korean population
    J M Piao
    Department of Public Health, Qingdao University Medical College, Qingdao, China
    Dis Esophagus 27:798-801. 2014
    ..87-1.62). We observed that the rs2274223 polymorphism was associated with an increased risk of ESCC in this Korean case-control study and that age may modify the association between the rs13042395 polymorphism and the risk of ESCC...
  45. ncbi [Relationship between rs2274223 and rs3765524 polymorphisms of PLCE1 and risk of esophageal squamous cell carcinoma in a Kazakh Chinese population]
    Yun zhao Chen
    Department of Pathology, Shihezi University School of Medicine Key Laboratories for Xinjiang Endemic and Ethnic Diseases, Shihezi 832002, China
    Zhonghua Bing Li Xue Za Zhi 42:795-800. 2013
    To investigate the association between the rs2274223 and rs3765524 polymorphism of phospholipase C epsilon 1 (PLCE1) gene and the susceptibility to develop esophageal squamous cell carcinoma (ESCC) in a pure Kazakh Chinese population.
  46. doi PLCε1: a potential target of RNA interference therapy for gastric cancer
    Fang Yan
    Department of Oncology, Changhai Hospital, Secondary Military Medical University, Shanghai 200240, PR China
    Biochem Biophys Res Commun 448:409-13. 2014
    ..It is implied that PLCε1 may inhibit the growth of gastric cancer cells via CCL-2 protein mediated pathway. These results suggest that PLCε1 might be an alternative molecular target for gastric cancer gene therapy...
  47. doi Novel functional variants locus in PLCE1 and susceptibility to digestive tract cancer in the Chinese population: a meta-analysis
    Fujiao Duan
    1 Department of Hospital Infection Management, Affiliated Tumor Hospital of Zhengzhou University, Henan Tumor Hospital, Zhengzhou, Henan P R China
    Int J Biol Markers 29:e301-9. 2014
    ..association studies (GWAS) have identified a shared susceptibility variation phospholipase C epsilon 1 (PLCE1) rs2274223 for esophageal squamous cell carcinoma (ESCC) and/or gastric cardia adenocarcinomas (GCA) in the ..
  48. ncbi Effects of PLCE1 gene silencing by RNA interference on cell cycling and apoptosis in esophageal carcinoma cells
    Li Zhao
    Department of Endoscopy, Peace Hospital Attached to Changzhi Medical College, Changzhi, China E mail
    Asian Pac J Cancer Prev 15:5437-42. 2014
    ..The phospholipase C? gene (PLCE1) encodes a novel ras-related protein effector mediating the effects of R-Ras on the actin cytoskeleton and ..
  49. pmc A single-gene cause in 29.5% of cases of steroid-resistant nephrotic syndrome
    Carolin E Sadowski
    Division of Nephrology, Department of Medicine, Boston Children s Hospital, Harvard Medical School, Boston, Massachusetts
    J Am Soc Nephrol 26:1279-89. 2015
    ..3%), between 7 and 12 years old (17.8%), and between 13 and 18 years old (10.8%). For PLCE1, specific mutations correlated with age of onset...
  50. ncbi PLCE1 rs2274223 polymorphism and susceptibility to esophageal cancer: a meta-analysis
    Li Yan Guo
    Department of Public Health, Jining Medical University, Jining, China E mail
    Asian Pac J Cancer Prev 15:9107-12. 2014
    To investigate and study the relationship between the PLCE1 rs2274223 gene polymorphism and susceptibility to esophageal cancer by meta-analysis.
  51. pmc Targeting oncogenic PLCE1 by miR-145 impairs tumor proliferation and metastasis of esophageal squamous cell carcinoma
    Xiao Bin Cui
    Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, Shihezi, China
    Oncotarget 7:1777-95. 2016
    Phospholipase C epsilon 1 (PLCE1) is a susceptibility gene in esophageal squamous cell carcinoma (ESCC). Nevertheless, the role of PLCE1 in ESCC tumorigenesis has not been elucidated...
  52. ncbi Genetic Variations in Phospholipase C-epsilon 1 (PLCE1) and Susceptibility to Colorectal Cancer Risk
    Oztas Ezgi
    Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Istanbul University, Beyazit, 34116, Istanbul, Turkey
    Biochem Genet 54:826-829. 2016
    ..Phosholipase C-epsilon 1 PLCE1 is one of the phospholipase family of enzymes and controls cellular responses leading to cell growth, ..
  53. ncbi WT1 and NPHS2 gene mutation analysis and clinical management of steroid-resistant nephrotic syndrome
    Aravind Selvin Kumar Ramanathan
    Department of Pediatric Nephrology, Institute of Child Health and Hospital for Children, Madras Medical College, Halls road, Egmore, Chennai, Tamil Nadu, 600 008, India
    Mol Cell Biochem . 2016
    ..of these children would be a risk with the possibility of mutational changes in podocyte genes (NPHS1, NPHS2, WT1, PLCE1). The mutation in podocyte genes is associated with SRNS...
  54. doi Elevated expression patterns and tight correlation of the PLCE1 and NF-κB signaling in Kazakh patients with esophageal carcinoma
    Xiao Bin Cui
    Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, North 4th Road, Shihezi, 832002, Xinjiang, People s Republic of China
    Med Oncol 31:791. 2014
    This study investigated the expression of the phospholipase C epsilon 1 (PLCE1) and nuclear factor-kappaB (NF-κB)-related proteins in Kazakh patients with esophageal squamous cell carcinoma (ESCC)...
  55. pmc Gastric cancer-molecular and clinical dimensions
    Roopma Wadhwa
    Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard FC10 3022, Houston, TX 77030, USA
    Nat Rev Clin Oncol 10:643-55. 2013
    ..A few germline (PLCE1) and somatic (ERBB2, ERBB3, PTEN, PI3K/AKT/mTOR, FGF, TP53, CDH1 and MET) alterations are emerging and some are ..
  56. doi Gastric cancer: epidemiologic aspects
    Carlos A Gonzalez
    Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology IDIBELL, Barcelona, Spain
    Helicobacter 18:34-8. 2013
    ..the association between IL8, IL10, TNF-b, TP53 and PSCA, while genetic variation at different genes such as XPG, PLCE1, HFE, ERCC5, EZH2, DOC2, CYP19A1, ALDH2, and CDH1 have been reported to be associated with GC risk...
  57. doi Multiple polymorphisms within the PLCE1 are associated with esophageal cancer via promoting the gene expression in a Chinese Kazakh population
    Xiao Bin Cui
    Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, China Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, Shihezi 832002, China
    Gene 530:315-22. 2013
    ..of esophageal squamous cell carcinoma (ESCC) identified a susceptibility locus in phospholipase C epsilon 1 (PLCE1) in Chinese Han populations, few studies further confirmed these findings in pure Kazakh population in which there ..
  58. doi Overexpression of PLCE1 in Kazakh esophageal squamous cell carcinoma: implications in cancer metastasis and aggressiveness
    Yun zhao Chen
    Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, Shihezi
    APMIS 121:908-18. 2013
    ..identified an esophageal squamous cell carcinoma (ESCC) susceptibility locus within phospholipase C epsilon 1 (PLCE1) gene, which encodes a phospholipase involved in intracellular signaling...
  59. doi A molecular genetic analysis of childhood nephrotic syndrome in a cohort of Saudi Arabian families
    Mohamed H Al-Hamed
    Department of Genetics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    J Hum Genet 58:480-9. 2013
    ..62 cases (representing 49 families with NS) from Saudi Arabia were screened for mutations in NPHS1, NPHS2, LAMB2, PLCE1, CD2AP, MYO1E, WT1, PTPRO and Nei endonuclease VIII-like 1 (NEIL1)...
  60. pmc Activity of PLCε contributes to chemotaxis of fibroblasts towards PDGF
    Marta Martins
    Institute of Structural and Molecular Biology, Division of Biosciences, University College London, Gower Street, London WC1E 6BT, UK
    J Cell Sci 125:5758-69. 2012
    ..Using PLCe1 null fibroblasts we show that cells deficient in PLCε have greatly reduced directionality towards PDGF-BB without ..
  61. doi Polymorphisms of tumor-related genes IL-10, PSCA, MTRR and NOC3L are associated with the risk of gastric cancer in the Chinese Han population
    Li juan Yuan
    Department of General Surgery, Tangdu Hospital of the Fourth Military Medical University, Xi an, Shaanxi 710038, China
    Cancer Epidemiol 36:e366-72. 2012
    ..In this study, 25 SNPs in genes for IL-10, IL-1B, MTRR, TNF-а, PSCA, PLCE1 and NOC3L were analyzed to further evaluate their associations with gastric cancer susceptibility in the Chinese ..
  62. pmc Progress in pathogenesis of proteinuria
    Aihua Zhang
    Department of Nephrology, Nanjing Children s Hospital, Nanjing Medical University, Nanjing 210008, China
    Int J Nephrol 2012:314251. 2012
    ..and membrane-associated guanylate kinase inverted 1 (MAGI-1), α3β1 integrin, WT1, phospholipase C epsilon-1 (PLCE1), Lmx1b, and MYH9, and mitochondrial disorders and circulating factors in the pathogenesis of glomerular ..
  63. pmc Systematic analysis of a novel human renal glomerulus-enriched gene expression dataset
    Maja T Lindenmeyer
    Division of Nephrology, University Hospital Zurich, Zurich, Switzerland
    PLoS ONE 5:e11545. 2010
    ..g. cdkn1, dag1, ddn, ehd3, myh9, nes, nphs1, nphs2, pdpn, pla2r1, plce1, podxl, ptpro, synpo, tcf21, tjp1, wt1)...
  64. ncbi Siah proteins induce the epidermal growth factor-dependent degradation of phospholipase Cepsilon
    Sanguk Yun
    Department of Life Science, Division of Molecular and Life Science, Pohang University of Science and Technology, Pohang, Kyung Buk 790 784, Republic of Korea
    J Biol Chem 283:1034-42. 2008
    ..Our results suggest that the Siah-dependent degradation of PLCepsilon plays a role in the regulation of growth factor-dependent cell growth...
  65. pmc Clinical utility of genetic testing in children and adults with steroid-resistant nephrotic syndrome
    Sheila Santin
    Molecular Biology Laboratory, Fundacio Puigvert, Universitat Autonoma de Barcelona, REDinREN, Instituto de Investigación Carlos III, Barcelona, Spain
    Clin J Am Soc Nephrol 6:1139-48. 2011
    ..Our aim was to compile the clinical and genetic data of eight podocyte genes analyzed in 110 cases (125 patients) with SRNS (ranging from congenital to adult onset) to provide a genetic testing approach...
  66. pmc Genome-wide association study of personality traits in bipolar patients
    Ney Alliey-Rodriguez
    Department of Psychiatry, The University of Chicago, Chicago, Illinois 60637, USA
    Psychiatr Genet 21:190-4. 2011
    ..Genome-wide association study was carried out on personality traits among bipolar patients as possible endophenotypes for gene discovery in bipolar disorder...
  67. pmc Respiratory-chain deficiency presenting as diffuse mesangial sclerosis with NPHS3 mutation
    Esra Baskin
    Department of Pediatric Nephrology, Baskent University, Ankara, Turkey
    Pediatr Nephrol 26:1157-61. 2011
    ..Percutaneous renal biopsy revealed diffuse mesangial sclerosis, and mutational analysis was compatible with PLCE1 mutation...
  68. doi Novel mutations in steroid-resistant nephrotic syndrome diagnosed in Tunisian children
    Ibtihel Benhaj Mbarek
    Biochemistry Department, Sahloul University Hospital, 4054, Sousse, Tunisia
    Pediatr Nephrol 26:241-9. 2011
    ..Several genes have been involved including NPHS1, NPHS2, WT1, PLCE1, and LAMB2...
  69. doi NPHS3: new clues for understanding idiopathic nephrotic syndrome
    Bernward G Hinkes
    Pediatr Nephrol 23:847-50. 2008
    ..identification of autosomal recessive nephrotic syndrome type 3 (NPHS3) caused by mutations in the phospholipase PLCE1 gene has, for the first time, shown steroid responsiveness in H-CHNS...
  70. ncbi Cardiovascular responses at the onset of passive leg cycle exercise in paraplegics with spinal cord injury
    S Muraki
    Department of Nutrition and Health Sciences, Faculty of Nursing and Nutrition, Siebold University of Nagasaki, 822 Yoshimutago Nagayo cho, Nishisonogi gun Nagasaki 851 2195, Japan
    Eur J Appl Physiol 81:271-4. 2000
    The purpose of this study was to examine the cardiovascular responses at the onset of passive leg cycle exercise (PLCE) in paraplegics with spinal cord injury (PSCI) to investigate the increase in venous return from the paralyzed lower ..
  71. pmc Genome-wide association study of smoking behaviours in patients with COPD
    Mateusz Siedlinski
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Thorax 66:894-902. 2011
    ..Associations of CHRNA3/CHRNA5 and CYP2A6 loci with CPD and DBH with smoking cessation are also likely of importance in the smoking behaviours of patients with COPD...
  72. doi Bigenic heterozygosity and the development of steroid-resistant focal segmental glomerulosclerosis
    Marije Löwik
    Department of Paediatric Nephrology, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Nephrol Dial Transplant 23:3146-51. 2008
    ..Mutated proteins expressed in podocytes cause proteinuria. The role of combined gene defects in the development of FSGS is less clear...
  73. doi Mutational analysis of the PLCE1 gene in steroid resistant nephrotic syndrome
    Olivia Boyer
    INSERM U983, Hopital Necker Enfants Malades, 149 rue de Sevres, Paris, France
    J Med Genet 47:445-52. 2010
    Mutations in the PLCE1 gene encoding phospholipase C epsilon 1 (PLCepsilon1) have been recently described in patients with early onset nephrotic syndrome (NS) and diffuse mesangial sclerosis (DMS)...
  74. pmc Genotype-phenotype correlations in non-Finnish congenital nephrotic syndrome
    Eduardo Machuca
    INSERM, U983, Hopital Necker Enfants Malades, Paris, France
    J Am Soc Nephrol 21:1209-17. 2010
    ..cases by mutational screening in 107 families (117 cases) by sequencing the entire coding regions of NPHS1, NPHS2, PLCE1, WT1, LAMB2, PDSS2, COQ2, and NEPH1...
  75. doi Analysis of recessive CD2AP and ACTN4 mutations in steroid-resistant nephrotic syndrome
    Genevieve Benoit
    INSERM, U574, Hopital Necker Enfants Malades, Paris, France
    Pediatr Nephrol 25:445-51. 2010
    ..the role of recessive CD2AP and ACTN4 mutations in a cohort of children with SRNS for which NPHS1, NPHS2, and PLCE1 mutations had been previously excluded...
  76. doi Molecular cloning and expression of phospholipase C epsilon 1 in zebrafish
    Weibin Zhou
    Departments of Pediatrics and Human Genetics, University of Michigan, 8220 MSRB3, 1150 W Medical Center Drive, Ann Arbor, MI 48109 5646, USA
    Gene Expr Patterns 9:282-8. 2009
    ..Phospholipase Cepsilon (PLCE1) is a unique member of the PLC family in that it carries both RasGEF and Ras-associating (RA) domains and may ..
  77. doi Genetic forms of nephrotic syndrome: a single-center experience in Brussels
    Khalid Ismaili
    Department of Pediatric Nephrology, Hopital Universitaire des Enfants Reine Fabiola, Universite Libre de Bruxelles ULB, Brussels, Belgium
    Pediatr Nephrol 24:287-94. 2009
    ..mutation analyses were positive in 4/20 (20%), NPHS2 mutations in 4/20 (20%), WT1 mutations in 4/20 (20%), and PLCE1 mutations in 3/20 (15%) families. NPHS1 and PLCE1 mutations were solely found in patients with the earliest onset...
  78. ncbi Identification of BRAF as a new interactor of PLCepsilon1, the protein mutated in nephrotic syndrome type 3
    Hassan Chaib
    Department of Pediatrics, University of Michigan Drive, Ann Arbor, MI 48109 5646, USA
    Am J Physiol Renal Physiol 294:F93-9. 2008
    ..Recently, we identified recessive mutations in the phospholipase C epsilon 1 gene (PLCE1) as a new cause of early-onset nephrotic syndrome and demonstrated interaction of PLCepsilon1 with IQGAP1...
  79. ncbi Piper longum Linn. Extract inhibits TNF-alpha-induced expression of cell adhesion molecules by inhibiting NF-kappaB activation and microsomal lipid peroxidation
    Naresh Singh
    Molecular Immunogenetics Laboratory, Institute of Genomics and Integrative Biology, University of Delhi Campus North, Mall Road, Delhi 110 007, India
    Phytomedicine 15:284-91. 2008
    ..Here, we have evaluated the effect of Piper longum chloroform extract (PlCE) on TNF-alpha-induced expression of ICAM-1 on endothelial cells and on NADPH-catalyzed rat liver microsomal lipid ..
  80. ncbi A new phospholipase-C-calcium signalling pathway mediated by cyclic AMP and a Rap GTPase
    M Schmidt
    Institut fur Pharmakologie, Universitatsklinikum Essen, 45122 Essen, Germany
    Nat Cell Biol 3:1020-4. 2001
    ..We provide evidence that these receptor responses are mediated by a Rap GTPase, specifically Rap2B, activated by a guanine-nucleotide-exchange factor (Epac) regulated by cAMP, and involve the recently identified PLC-epsilon isoform...
  81. doi shRNA targeting PLCε inhibits bladder cancer cell growth in vitro and in vivo
    Honglin Cheng
    Department of Urological Surgery, First Affiliated Hospital, Chongqing Medical University, Chongqing, People s Republic of China
    Urology 78:474.e7-11. 2011
    ..To investigate the role of phospholipase Cε (PLCε) by silencing PLCε with short hairpin RNA (shRNA) in human bladder cancer cells BIU-87 in vitro and in vivo...
  82. ncbi Renin-angiotensin axis blockade reduces proteinuria in presymptomatic patients with familial FSGS
    Lawrence Copelovitch
    Department of Pediatrics, Division of Nephrology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Pediatr Nephrol 22:1779-84. 2007
    ..are associated with six different mutations in genes affecting the podocyte (NPHS2, ACTN4, CD2AP, WT1, TRPC6, and PLCE1). Immunosuppressive agents are often unsuccessful in treating this condition...
  83. doi PLCε cooperates with the NF-κB pathway to augment TNFα-stimulated CCL2/MCP1 expression in human keratinocyte
    Yuko Harada
    Division of Molecular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan
    Biochem Biophys Res Commun 414:106-11. 2011
    ..This pathway can cooperate with the NF-κB pathway to achieve a synergistic TNFα-stimulated CCL2 induction in keratinocytes...
  84. ncbi Stimulation of phospholipase C-epsilon by the M3 muscarinic acetylcholine receptor mediated by cyclic AMP and the GTPase Rap2B
    Sandrine Evellin
    Institut fur Pharmakologie, Universitatsklinikum Essen, D 45122 Essen, Germany
    J Biol Chem 277:16805-13. 2002
    ....
  85. ncbi Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon
    Chunhua Song
    Division of Molecular Biology, Department of Molecular and Cellular Biology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Oncogene 21:8105-13. 2002
    ..Therefore, the phospholipase C signal is suggested to be critical for survival and growth of BaF3 cells...
  86. ncbi Injuries of the sterno-clavicular joint in backpackers
    A Shoaib
    University Hospital, Cardiff
    J R Army Med Corps 148:267-9. 2002
    ..We describe two cases, and reflect on the factors that may have led to the injuries, noting that the current PLCE (personal load carrying equipment) may also increase the risk of this condition...
  87. pmc Activation of CD4 T cells by Raf-independent effectors of Ras
    Jan Czyzyk
    Section of Immunobiology, Department of Pathology, and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 100:6003-8. 2003
    ..Hence T cell activation can be critically regulated by the Ras effector pathway independent from Raf that can be mimicked by phospholipase C epsilon...
  88. ncbi Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease
    A R Morgan
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Am J Med Genet B Neuropsychiatr Genet 144:762-70. 2007
    ..ZWINT, ANK3, UBE2D1, CDC2, SIRT1, JDP1, NET7, SUPV3L1, NEN3, SAR1, SGPL1, SEC24C, CAMK2G, PP3CB, SNCG, CH25H, PLCE1, ANXV111) in the MRC genetic resource for LOAD...
  89. ncbi Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk
    Johan Lennartsson
    Ludwig Institute for Cancer Research, Biomedical Centre, P O Box 595, SE 751 24 Uppsala, Sweden
    Exp Cell Res 288:110-8. 2003
    ..Together these data support a model where c-Src phosphorylates the receptor, thereby creating docking sites for SH2 domain containing proteins, leading to recruitment of Crk to the receptor...
  90. ncbi Inhibition of phospholipase C-epsilon by Gi-coupled receptors
    Frank vom Dorp
    Institut fur Pharmakologie, Universitatsklinikum Essen, Hufelandstrasse 55, D 45122 Essen, Germany
    Cell Signal 16:921-8. 2004
    ..In summary, our data indicate that Gi-coupled receptors can inhibit PLC-epsilon, most likely by suppressing formation of cyclic AMP required for Epac-mediated Rap2B activation...
  91. ncbi The small GTPase R-Ras regulates organization of actin and drives membrane protrusions through the activity of PLCepsilon
    Aude S Ada-Nguema
    Department of Pharmacology, University of Wisconsin Madison, Madison, WI 53706, USA
    J Cell Sci 119:1307-19. 2006
    ..Overall, these data suggest that R-Ras signaling regulates the organization of the actin cytoskeleton to sustain membrane protrusion through the activity of PLCepsilon...
  92. pmc Exclusion of homozygous PLCE1 (NPHS3) mutations in 69 families with idiopathic and hereditary FSGS
    Rasheed Gbadegesin
    Department of Pediatrics, Duke University Medical Center, Durham, NC, 27710, USA
    Pediatr Nephrol 24:281-5. 2009
    ..Mutations in PLCE1/NPHS3 have recently been reported as a cause of nephrotic syndrome characterized by diffuse mesangial sclerosis (..

Research Grants6

  1. Exon capture and large-scale sequencing for disease-cause identification, early d
    Friedhelm Hildebrandt; Fiscal Year: 2010
    ..When identifying by HM recessive PLCE1 mutations as a rare cause of SRNS (~1%), we recapitulated the disease in zebrafish, thereby generating a model for ..
  2. Friedhelm Hildebrandt; Fiscal Year: 2016
    ..More importantly, by discovering mutations in the genes PLCE1 and COQ6, we identified by genetic mapping novel rare single-gene causes of NS that may be amenable to specific ..
  3. Chung Owyang; Fiscal Year: 2016
    ..acting through the PG pathway, triggers cyclic AMP synthesis in the NG, which in turn, activates a novel Epac-Rap-PLCe pathway to stimulate the calcium-sensitive 2 pore K+ channel TRESK...
  4. Chung Owyang; Fiscal Year: 2015
    ..further postulate that high glucose triggers cyclic AMP (cAMP) synthesis, which in turn activates a novel Epac-Rap-PLCe pathway to stimulate the calcium-sensitive 2 pore potassium channel TRESK resulting in hyperpolarization and ..
  5. Alan V Smrcka; Fiscal Year: 2016
    ..We have identified a novel a cAMP-dependent pathway, involving the novel cAMP binding protein, Epac, and PLCe that increases cardiac calcium-induced calcium release (CICR) and ionotropic responses to [unreadable]-adrenergic ..
  6. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    ANASTACIA BERZAT; Fiscal Year: 2005
    ..One possible mediator of R-Ras function is the novel phospholipase C protein, PLCepsilon (PLCe). R-Ras binds and activates the phospholipase activity of PLCe in vitro...