PLCB2

Summary

Gene Symbol: PLCB2
Description: phospholipase C beta 2
Alias: PLC-beta-2, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2, phosphoinositide phospholipase C-beta-2
Species: human

Top Publications

  1. ncbi Mechanosensitivity of human osteosarcoma cells and phospholipase C beta2 expression
    M Hoberg
    Department of Orthopaedics, University of Tuebingen, Germany
    Biochem Biophys Res Commun 333:142-9. 2005
  2. ncbi Phospholipase C-beta 2 promotes mitosis and migration of human breast cancer-derived cells
    Valeria Bertagnolo
    Signal Transduction Unit, Laboratory of Cell Biology, Section of Human Anatomy, Department of Morphology and Embryology, University G D Annunzio Chieti Pescara, Chieti, Italy
    Carcinogenesis 28:1638-45. 2007
  3. ncbi PLC-beta2 is highly expressed in breast cancer and is associated with a poor outcome: a study on tissue microarrays
    Valeria Bertagnolo
    Signal Transduction Unit, Laboratory of Cell Biology, Section of Human Anatomy, Department of Morphology and Embryology, University of Ferrara, Ferrara, Italy
    Int J Oncol 28:863-72. 2006
  4. ncbi Fluorescence studies suggest a role for alpha-synuclein in the phosphatidylinositol lipid signaling pathway
    Vijaya Narayanan
    Department of Physiology and Biophysics, State University of New York, Stony Brook, New York 11794 8661, USA
    Biochemistry 44:462-70. 2005
  5. ncbi Phospholipase C-beta 1 is a GTPase-activating protein for Gq/11, its physiologic regulator
    G Berstein
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas 75235 9041
    Cell 70:411-8. 1992
  6. doi Identifying prognostic biomarkers based on aberrant DNA methylation in kidney renal clear cell carcinoma
    Guang Chen
    Department of Urology, the 4th affiliated hospital of Harbin Medical University, Harbin 150001, China
    Oncotarget . 2016
  7. ncbi Nuclear factor-κB regulates expression of platelet phospholipase C-β2 (PLCB2)
    Guangfen Mao
    A Koneti Rao, MD, Sol Sherry Thrombosis Research Center, Temple University School of Medicine, 3400 North Broad Street, MRB 204, Philadelphia, PA 19140, USA, Tel 1 215 707 4684, Fax 1 215 707 2783, E mail
    Thromb Haemost 116:931-940. 2016
  8. pmc Gnb isoforms control a signaling pathway comprising Rac1, Plcβ2, and Plcβ3 leading to LFA-1 activation and neutrophil arrest in vivo
    Helena Block
    Department of Anaesthesiology, Intensive Care and Pain Medicine, University of Muenster, Muenster, Germany
    Blood 127:314-24. 2016
  9. doi Protective effects of endothelin receptor A and B inhibitors against doxorubicin-induced cardiomyopathy
    Matthias Schwebe
    Center of Drug Absorption and Transport C_DAT, Institute of Pharmacology, University Medicine, Greifswald, Germany
    Biochem Pharmacol 94:109-29. 2015
  10. doi Profiling of concanavalin A-binding glycoproteins in human hepatic stellate cells activated with transforming growth factor-β1
    Yannan Qin
    Department of Genetics and Molecular Biology, Xi an Jiaotong University College of Medicine, Xi an 710061, Shaanxi, China
    Molecules 19:19845-67. 2014

Scientific Experts

  • ANGARA KONETI RAO
  • Vincenza Rita Lo Vasco
  • Valeria Bertagnolo
  • Merel Jw Adjobo-Hermans
  • SUZANNE F SCARLATA
  • S H Park
  • M Hoberg
  • Yuanjian Guo
  • Samuel Joseph Leibovich
  • Federica Brugnoli
  • Guangfen Mao
  • Urszula Golebiewska
  • Guang Chen
  • Helena Block
  • Matthias Schwebe
  • Yannan Qin
  • Auke P Verhaar
  • Zhizeng Sun
  • Denny Schanze
  • Sabine Suire
  • Satya P Kunapuli
  • Andréane Cartier
  • Orit Gutman
  • Alexey A Fushan
  • Jennifer A Juno
  • Alberto Bavelloni
  • Silvano Capitani
  • Yong Sun Maeng
  • Jolanta Idkowiak-Baldys
  • Jennifer L Lee
  • Alan V Smrcka
  • Alex U Singer
  • Brooke Harmon
  • Tomoko Kawai
  • Liansheng Sun
  • Tabetha M Bonacci
  • Vijaya Narayanan
  • Bidhan C Bandyopadhyay
  • D W Morris
  • Daniel Riad
  • Jianguo Jin
  • Wanhai Xu
  • Giulia Germena
  • Jason T Snyder
  • Charlotte Sohlbach
  • Alexander Zarbock
  • Jan Rossaint
  • Yihan Wang
  • Scott I Simon
  • Anika Stadtmann
  • Lu Wang
  • Klaus Ley
  • Dianqing Wu
  • Axel Poesch
  • Eberhard Scheuch
  • Karina Bonitz
  • Heyo K Kroemer
  • Elke Hammer
  • Henry W S Schroeder
  • Judith V Monzel
  • John Sondek
  • Thomas Budde
  • T Kendall Harden
  • Sabine Ameling
  • Markus Grube
  • Susanne Budde
  • Kathleen Schult
  • Ralf Ewert
  • Sandra Bien-Möller
  • Stefan Oswald
  • Alastair J Barr
  • Loren W Runnels
  • Chen Huang
  • Zheng Li
  • Ganglong Yang
  • Elizabeth Buck
  • Liyuan Jia
  • Yaogang Zhong
  • Tianran Ma
  • Mark Lowenberg
  • Gijs R van den Brink
  • Songhai Chen
  • Maikel P Peppelenbosch
  • Daniel W Hommes
  • Silvia Grassilli
  • Maria Palomba
  • Manuela Piazzi
  • Manon E Wildenberg
  • Anne Christine W Vos
  • Ervin Nika

Detail Information

Publications55

  1. ncbi Mechanosensitivity of human osteosarcoma cells and phospholipase C beta2 expression
    M Hoberg
    Department of Orthopaedics, University of Tuebingen, Germany
    Biochem Biophys Res Commun 333:142-9. 2005
    ..Fluid shear flow experiments with MG-63 lacking PLC beta2 revealed a significantly higher level of cells losing attachment to coverslips and a significantly lower number of cells increasing intracellular free calcium...
  2. ncbi Phospholipase C-beta 2 promotes mitosis and migration of human breast cancer-derived cells
    Valeria Bertagnolo
    Signal Transduction Unit, Laboratory of Cell Biology, Section of Human Anatomy, Department of Morphology and Embryology, University G D Annunzio Chieti Pescara, Chieti, Italy
    Carcinogenesis 28:1638-45. 2007
    ..On the basis of these data, PLC-beta2 may constitute a molecular marker of breast tumor cells able to monitor the progression to invasive cancers and a target for novel therapeutic breast cancer strategies...
  3. ncbi PLC-beta2 is highly expressed in breast cancer and is associated with a poor outcome: a study on tissue microarrays
    Valeria Bertagnolo
    Signal Transduction Unit, Laboratory of Cell Biology, Section of Human Anatomy, Department of Morphology and Embryology, University of Ferrara, Ferrara, Italy
    Int J Oncol 28:863-72. 2006
    ..Our data indicate that PLC-beta2 expression correlates highly with breast cancer malignancy and suggest that it can be included, as an independent marker, among the prognostic indicators in current use...
  4. ncbi Fluorescence studies suggest a role for alpha-synuclein in the phosphatidylinositol lipid signaling pathway
    Vijaya Narayanan
    Department of Physiology and Biophysics, State University of New York, Stony Brook, New York 11794 8661, USA
    Biochemistry 44:462-70. 2005
    ..Given that Ca(2+) and dopamine regulation are mediated through PLCbeta and G protein signals, our results suggest that alpha-synuclein may play a role in inositol phospholipid signaling...
  5. ncbi Phospholipase C-beta 1 is a GTPase-activating protein for Gq/11, its physiologic regulator
    G Berstein
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas 75235 9041
    Cell 70:411-8. 1992
    ..Such GAP activity by an effector coupled to a trimeric G protein can reconcile slow GTP hydrolysis by pure G proteins in vitro with fast physiologic deactivation of G protein-mediated signaling...
  6. doi Identifying prognostic biomarkers based on aberrant DNA methylation in kidney renal clear cell carcinoma
    Guang Chen
    Department of Urology, the 4th affiliated hospital of Harbin Medical University, Harbin 150001, China
    Oncotarget . 2016
    ..We validated four DNA methylation signatures (RAC2, PLCB2, VAV1, and PARVG) as being highly correlated with prognosis in KIRC...
  7. ncbi Nuclear factor-κB regulates expression of platelet phospholipase C-β2 (PLCB2)
    Guangfen Mao
    A Koneti Rao, MD, Sol Sherry Thrombosis Research Center, Temple University School of Medicine, 3400 North Broad Street, MRB 204, Philadelphia, PA 19140, USA, Tel 1 215 707 4684, Fax 1 215 707 2783, E mail
    Thromb Haemost 116:931-940. 2016
    Phospholipase C (PLC)-β2 (gene PLCB2) is a critical regulator of platelet responses upon activation. Mechanisms regulating of PLC-β2 expression in platelets/MKs are unknown...
  8. pmc Gnb isoforms control a signaling pathway comprising Rac1, Plcβ2, and Plcβ3 leading to LFA-1 activation and neutrophil arrest in vivo
    Helena Block
    Department of Anaesthesiology, Intensive Care and Pain Medicine, University of Muenster, Muenster, Germany
    Blood 127:314-24. 2016
    ..Taken together, we demonstrated that all Gnb isoforms are required for chemokine-induced downstream signaling, and Rac1, Plcβ2, and Plcβ3 are critically involved in integrin activation and leukocyte arrest. ..
  9. doi Protective effects of endothelin receptor A and B inhibitors against doxorubicin-induced cardiomyopathy
    Matthias Schwebe
    Center of Drug Absorption and Transport C_DAT, Institute of Pharmacology, University Medicine, Greifswald, Germany
    Biochem Pharmacol 94:109-29. 2015
    ..g. Stat3, Pim1, Akt1, Plcb2), fibrosis (e.g. Myl4), energy production (e.g. Ant1) or oxidative stress (e.g. Aox1)...
  10. doi Profiling of concanavalin A-binding glycoproteins in human hepatic stellate cells activated with transforming growth factor-β1
    Yannan Qin
    Department of Genetics and Molecular Biology, Xi an Jiaotong University College of Medicine, Xi an 710061, Shaanxi, China
    Molecules 19:19845-67. 2014
    ..g., calreticulin) and calcium signaling (e.g., 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase β-2 [PLCB2]) were specifically identified in activated LX-2 cells...
  11. doi Neuropeptide Y reduces the expression of PLCB2, PLCD1 and selected PLC genes in cultured human endothelial cells
    V R Lo Vasco
    Department Organi di Senso, Policlinico Umberto I, Faculty of Medicina e Odontoiatria, Sapienza University of Rome, Viale del Policlinico 155, 00185, Rome, Italy
    Mol Cell Biochem 394:43-52. 2014
    ..The most significant effects were observed for PLCB2 and PLCD1, both isoforms recruited by means of G-proteins and G-protein-coupled receptors...
  12. pmc In triple negative breast tumor cells, PLC-β2 promotes the conversion of CD133high to CD133low phenotype and reduces the CD133-related invasiveness
    Federica Brugnoli
    Signal Transduction Unit, Section of Anatomy and Histology, Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Via Fossato di Mortara 70, 44121 Ferrara, Italy
    Mol Cancer 12:165. 2013
    ....
  13. ncbi Concentration of enzyme-dependent activation of PLC-beta 1 and PLC-beta 2 by G alpha 11 and beta gamma-subunits
    A Paterson
    Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill 27599 7365, USA
    Cell Signal 7:709-20. 1995
    ....
  14. ncbi Regulation of phospholipase C-beta 3 activity by Na+/H+ exchanger regulatory factor 2
    J I Hwang
    Department of Life Science, National Creative Research Initiative Center for Calcium and Learning, Division of Molecular and Life Science and School of Environmental Engineering, Pohang University of Science and Technology, Pohang 790 784, South Korea
    J Biol Chem 275:16632-7. 2000
    ..Taken together, the data suggest that NHERF2 may act as a modulator underlying the process of PLC-beta3-mediated signaling...
  15. pmc Induction of the Galpha(q) signaling cascade by the human immunodeficiency virus envelope is required for virus entry
    Brooke Harmon
    Division of Molecular Oncology, Washington University School of Medicine, St Louis, Missouri, USA
    J Virol 82:9191-205. 2008
    ..These results could provide a new focus for therapeutic intervention with drugs targeting host signaling mediators rather than viral molecules, a strategy which is less likely to result in resistance...
  16. ncbi Clarifying the role of G protein signaling in HIV infection: new approaches to an old question
    Jennifer A Juno
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada
    AIDS Rev 12:164-76. 2010
    ....
  17. doi Superantigen-induced steroid resistance depends on activation of phospholipase Cβ2
    Auke P Verhaar
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, 2300RC Leiden, The Netherlands
    J Immunol 190:6589-95. 2013
    ..In conclusion, we find that effects of glucocorticoids on TCR-induced T cell proliferation are mainly nongenomic and can be bypassed by the activation of an Lck-independent signaling pathway...
  18. pmc WDR26 functions as a scaffolding protein to promote Gβγ-mediated phospholipase C β2 (PLCβ2) activation in leukocytes
    Zhizeng Sun
    Department of Pharmacology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 288:16715-25. 2013
    ..These findings have identified a novel mechanism of regulating Gβγ signaling through a scaffolding protein...
  19. doi PLCβ isoforms differ in their subcellular location and their CT-domain dependent interaction with Gαq
    Merel J W Adjobo-Hermans
    Swammerdam Institute for Life Sciences, Section of Molecular Cytology, van Leeuwenhoek Centre for Advanced Microscopy, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands
    Cell Signal 25:255-63. 2013
    ..These findings suggest that under physiological circumstances, PLCβ3 and Gαq interact in a kiss-and-run fashion, likely due to the GTPase-activating activity of PLCβ towards Gαq...
  20. pmc γ-Synuclein interacts with phospholipase Cβ2 to modulate G protein activation
    Urszula Golebiewska
    Department of Physiology and Biophysics, Stony Brook University, Stony Brook, New York, United States of America
    PLoS ONE 7:e41067. 2012
    ..We also find that Gβγ can reverse γ-synuclein inhibition without dissociating the γ-synuclein- PLCβ2- complex. These studies point to a role of γ-synuclein in promoting a more robust G protein activation of PLCβ2...
  21. pmc GPCR activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4
    Sabine Suire
    The Inositide Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge, UK
    EMBO J 31:3118-29. 2012
    ..We provide evidence that G protein-coupled receptors (GPCRs) can stimulate PLCb2/b3 and diacylglycerol- dependent activation of the RasGEF, RasGRP4 in neutrophils...
  22. doi WDR36 acts as a scaffold protein tethering a G-protein-coupled receptor, Gαq and phospholipase Cβ in a signalling complex
    Andréane Cartier
    Service de Rhumatologie, Departement de Medecine, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, Institut de Pharmacologie de Sherbrooke and Centre de Recherche Clinique Etienne Lebel, Sherbrooke, QC J1H 5N4, Canada
    J Cell Sci 124:3292-304. 2011
    ..We report that WDR36 acts as a new scaffold protein tethering a G-protein-coupled receptor, Gαq and PLCβ in a signalling complex...
  23. pmc Sustained receptor stimulation leads to sequestration of recycling endosomes in a classical protein kinase C- and phospholipase D-dependent manner
    Jolanta Idkowiak-Baldys
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Biol Chem 284:22322-31. 2009
    ..Taken together, these results demonstrate a novel role for sustained receptor stimulation in regulation of intracellular trafficking, and this process requires sustained stimulation of PKC and PLD...
  24. doi Endothelial progenitor cell homing: prominent role of the IGF2-IGF2R-PLCbeta2 axis
    Yong Sun Maeng
    Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea
    Blood 113:233-43. 2009
    ..The utilization of the IGF2/IGF2R system may therefore be useful for the development of novel means to treat angiogenesis-dependent diseases...
  25. pmc Differential regulation of phospholipase C-beta2 activity and membrane interaction by Galphaq, Gbeta1gamma2, and Rac2
    Orit Gutman
    Department of Neurobiology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    J Biol Chem 285:3905-15. 2010
    ..Finally, activation by betagamma recruits PLCbeta(2) to the membrane by transient interactions, leading to fast "surfing" diffusion along the membrane, sampling large regions for dispersed PtdInsP(2) populations...
  26. pmc The small G protein Rac1 activates phospholipase Cdelta1 through phospholipase Cbeta2
    Yuanjian Guo
    Department of Physiology and Biophysics, Stony Brook University, Stony Brook, New York 11794 8661, USA
    J Biol Chem 285:24999-5008. 2010
    ..Through PLCbeta2, PLCdelta1 activation is linked to surface receptors as well as signals that mediate cytoskeletal pathways...
  27. pmc Association between common variation in genes encoding sweet taste signaling components and human sucrose perception
    Alexey A Fushan
    National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD 20850, USA
    Chem Senses 35:579-92. 2010
    ..Collectively, GNAT3 polymorphisms explain 13% of the variation in sucrose perception. Our findings underscore the importance of common genetic variants influencing human taste perception...
  28. doi Evaluation of conserved and ultra-conserved non-genic sequences in chromosome 15q15-linked periodic catatonia
    Denny Schanze
    Institute of Human Genetics, University of Erlangen Nuremberg, Erlangen, Germany
    Am J Med Genet B Neuropsychiatr Genet 159:77-86. 2012
    ..Further CNGs were identified at the PLCB2 and DLL4 locus or located intergenic between TYRO3 and MAPKBP1...
  29. ncbi Characterization of the phosphatidylinositol-specific phospholipase C isozymes present in the bovine parathyroid and in human kidney HEK293 cells stably transfected with the human parathyroid Ca2+-sensing receptor
    E Dare
    Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden
    J Mol Endocrinol 21:7-17. 1998
    ..PLCdelta2, showing predominantly nuclear localization in the parathyroid, was the sole PI-PLC isozyme with higher levels of expression in CaR-transfected HEK cells...
  30. ncbi Mitogen-activated protein kinase activation requires two signal inputs from the human anaphylatoxin C5a receptor
    A M Buhl
    Department of Chemistry, Aarhus University, Denmark
    J Biol Chem 270:19828-32. 1995
    ..These results demonstrate that two independent signals are required for the maximal activation of MAP kinase by G protein-coupled receptors...
  31. ncbi Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line
    G Zauli
    Institute of Human Anatomy, University of Ferrara, Italy
    Eur J Immunol 25:2695-700. 1995
    ..The relevance of these findings for a better understanding of the biological functions of extracellular Tat is discussed...
  32. ncbi Purification and characterization of membrane-bound phospholipase C specific for phosphoinositides from human platelets
    Y Banno
    Department of Biochemistry, Gifu University School of Medicine, Japan
    J Biol Chem 263:11459-65. 1988
    ..The mPLC-I and mPLC-II activities were increased by Ca2+, but not by Mg2+, while Hg2+, Fe2+, Cu2+, and La3+ were inhibitory. GTP-binding proteins (Gi, Go, and Ki-ras protein) had no significant effects on the mPLC-II activity...
  33. pmc Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway
    D Cefai
    Laboratoire d Immunologie Cellulaire et Tissulaire, Group Hospitalier GH Pitié Salpétrière, Paris, France
    J Clin Invest 86:2117-24. 1990
    ....
  34. ncbi Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2
    D Park
    Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 267:16048-55. 1992
    ..see also accompanying article (Lee, C. H., Park, D., Wu, D., Rhee, S. G., and Simon, M. I. (1992) J. Biol. Chem. 267, 16044-16047)...
  35. ncbi Phospholipase Cbeta2 binds to and inhibits phospholipase Cdelta1
    Yuanjian Guo
    Department of Physiology and Biophysics, State University of New York, Stony Brook, New York 11794 8661, USA
    J Biol Chem 280:1438-47. 2005
    ..These results support a model in which PLCbeta2 suppresses the basal catalytic activity of PLCdelta1, which is relieved by binding of Gbetagamma subunits to PLCbeta2 allowing for amplified calcium signals...
  36. ncbi Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1)
    A Caricasole
    Biology Department, GlaxoWellcome Medicines Research Centre, Verona, Italy
    Biochim Biophys Acta 1517:63-72. 2000
    ..Finally, we characterized the structure of the PLC beta 1 locus and confirmed its mapping to human chromosome 20...
  37. ncbi A unique fold of phospholipase C-beta mediates dimerization and interaction with G alpha q
    Alex U Singer
    Department of Pharmacology, The University of North Carolina at Chapel Hill, North Carolina 27599, USA
    Nat Struct Biol 9:32-6. 2002
    ..Effector dimerization, as highlighted by PLC-betas, provides a viable mechanism for regulating signaling cascades linked to heterotrimeric G proteins...
  38. ncbi The TRPM7 channel is inactivated by PIP(2) hydrolysis
    Loren W Runnels
    Howard Hughes Medical Institute, Children s Hospital, Harvard Medical School, Enders 1309, 320 Longwood Avenue, Boston, MA 02115, USA
    Nat Cell Biol 4:329-36. 2002
    ..We conclude that receptor-mediated activation of PLC results in the hydrolysis of localized PIP(2), leading to inactivation of the TRPM7 channel...
  39. ncbi Regulation of the lateral association of phospholipase Cbeta2 and G protein subunits by lipid rafts
    Suzanne Scarlata
    Department of Physiology and Biophysics, State University of New York at Stony Brook, Stony Brook, New York 11794 8661, USA
    Biochemistry 41:7092-9. 2002
    ..These results suggest a model in which lipid rafts occlude the PLCbeta2 interaction site on Gbetagamma subunits by localizing these subunits at the domain interface...
  40. ncbi Selective up-regulation of phospholipase C-beta2 during granulocytic differentiation of normal and leukemic hematopoietic progenitors
    Valeria Bertagnolo
    Signal Transduction Unit Laboratory of Cell Biology, Section of Human Anatomy, Department of Morphology and Embryology, University of Ferrara, Italy
    J Leukoc Biol 71:957-65. 2002
    ..Moreover, PLC-beta2 levels can predict the in vivo responsiveness to ATRA of APL patients...
  41. ncbi Phospholipase C-beta 2 interacts with mitogen-activated protein kinase kinase 3
    Alastair J Barr
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Biochem Biophys Res Commun 293:647-52. 2002
    ..p38MAPK also co-immunoprecipitated with PLC-beta 2. The data suggest that PLC-beta 2 serves an unappreciated role assembling components of the p38MAPK signaling module...
  42. ncbi Role of dynamic interactions in effective signal transfer for Gbeta stimulation of phospholipase C-beta 2
    Elizabeth Buck
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    J Biol Chem 277:49707-15. 2002
    ....
  43. ncbi The pleckstrin homology domain of phospholipase C-beta2 as an effector site for Rac
    Jason T Snyder
    Department of Pharmacology, The University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 278:21099-104. 2003
    ..Together, these findings present a quantitative evaluation of the direct interactions between Rac GTPases and PLC-beta isozymes and define a novel role for the PH domain of PLC-beta2 as a putative effector site for Rac GTPases...
  44. ncbi The Pleckstrin homology domains of phospholipases C-beta and -delta confer activation through a common site
    Yuanjian Guo
    Department of Physiology and Biophysics, State University of New York, Stony Brook, New York 11794 8661, USA
    J Biol Chem 278:29995-30004. 2003
    Mammalian inositol-specific phospholipase C-beta2 (PLC beta 2) and PLC delta 1 differ in their cellular activators...
  45. ncbi Association analysis of two candidate phospholipase genes that map to the chromosome 15q15.1-15.3 region associated with reading disability
    D W Morris
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 129:97-103. 2004
    ..Both were phospholipase genes, phospholipase C beta 2 (PLCB2) and phospholipase A2, group IVB (cytosolic; PLA2G4B). D15S944 is located within PLCB2 and is 1.6 Mb from PLA2G4B...
  46. doi Revisiting Libman-Sacks endocarditis: a historical review and update
    Jennifer L Lee
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA 95616, USA
    Clin Rev Allergy Immunol 36:126-30. 2009
    ..Improvements in imaging modalities, particularly in echocardiography, have allowed better estimation of the prevalence of the disease, but further investigation is still needed into its pathogenesis, treatment, and association with APS...
  47. ncbi Regulatory interactions between the amino terminus of G-protein betagamma subunits and the catalytic domain of phospholipase Cbeta2
    Tabetha M Bonacci
    Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, New York 14642, USA
    J Biol Chem 280:10174-81. 2005
    ....
  48. ncbi Apical localization of a functional TRPC3/TRPC6-Ca2+-signaling complex in polarized epithelial cells. Role in apical Ca2+ influx
    Bidhan C Bandyopadhyay
    Secretory Physiology Section, Gene Therapy and Therapeutics Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 280:12908-16. 2005
    ..These data demonstrate functional localization of TRPC3/TRPC6 channels in the apical region of polarized epithelial cells. In salivary gland ducts this could contribute to the regulation of salivary [Ca2+] and secretion...
  49. ncbi Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat
    N J Haughey
    Department of Pharmacology and Therapeutics, University of Manitoba Faculty of Medicine, Winnipeg, Canada
    J Neurochem 73:1363-74. 1999
    ....
  50. ncbi Assignment1 of human PLCB2 encoding PLC beta2 to human chromosome 15q15 by fluorescence in situ hybridization
    S H Park
    Institute of Human Genetics, Department of Anatomy, College of Medicine, Korea University, Seoul South Korea
    Cytogenet Cell Genet 83:48-9. 1998
  51. ncbi PLC-beta2 activity on actin-associated polyphosphoinositides promotes migration of differentiating tumoral myeloid precursors
    Federica Brugnoli
    Signal Transduction Unit, Laboratory of Cell Biology, Section of Human Anatomy, Department of Morphology and Embryology, University of Ferrara, Ferrara, Italy
    Cell Signal 19:1701-12. 2007
    ....
  52. ncbi Alternative splice variants of phospholipase C-beta2 are expressed in platelets: effect on Galphaq-dependent activation and localization
    Liansheng Sun
    Sol Sherry Thrombosis Research Center, Philadelphia, PA 19140, USA
    Platelets 18:217-23. 2007
    ..In transfected CV-1 cells, PLC-beta2a is relatively more enriched in the nuclei than PLC-beta2b suggesting that the two variants may have different effects in cell proliferation and differentiation...
  53. ncbi Gene expression signature in peripheral blood cells from medical students exposed to chronic psychological stress
    Tomoko Kawai
    Department of Stress Science, Institute of Health Biosciences, University of Tokushima Graduate School, 3 18 15 Kuramoto cho, Tokushima, Japan
    Biol Psychol 76:147-55. 2007
    ..Of the 24 genes, real-time PCR validated changes in mRNA levels of 10 (PLCB2, CSF3R, ARHGEF1, DPYD, CTNNB1, PPP3CA, POLM, IRF3, TP53, and CCNI)...
  54. ncbi Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF
    Y Tang
    Neurobiotechnology Center and Department of Neuroscience, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 275:37559-64. 2000
    ..The interaction with the PDZ protein may constitute an important mechanism for distribution and regulation of store-operated channels...

Research Grants3

  1. A role for miRNAs in adenosine-dependent alternative macrophage activation
    Samuel Joseph Leibovich; Fiscal Year: 2013
    ..induction of A2AR and A2BR expression, induction of HIF-1a expression, and suppression of phospholipase-Cb2 (PLCb2) expression at the post-transcriptional level by destabilization of its mRNA...
  2. SIGNAL TRANSDUCTION DEFECTS IN HUMAN PLATELETS
    A Rao; Fiscal Year: 2006
    ..Overall, our studies will provide new important insights into the regulation of two key platelet proteins (G-alpha-q and PLC-beta2) involved in platelet signaling and into the signaling mechanisms in platelets. ..
  3. Aberrant Platelet Mechanisms in Inherited Human Platelet Function Disorders
    ANGARA KONETI RAO; Fiscal Year: 2010
    ..Our studies will provide a wealth of information on platelet mechanisms and on potential new targets for antithrombotic therapy. ..