PLCB1

Summary

Gene Symbol: PLCB1
Description: phospholipase C beta 1
Alias: EIEE12, PI-PLC, PLC-154, PLC-I, PLC-beta-1, PLC154, PLCB1A, PLCB1B, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1, 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate, inositoltrisphosphohydrolase, monophosphatidylinositol phosphodiesterase, phosphoinositidase C, phospholipase C, beta 1 (phosphoinositide-specific), phospholipase C-I, triphosphoinositide phosphodiesterase
Species: human

Top Publications

  1. ncbi Nuclear inositide signaling: an appraisal of phospholipase C beta 1 behavior in myelodysplastic and leukemia cells
    Lucio Cocco
    Cellular Signalling Laboratory, Department of Anatomical Sciences, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Adv Enzyme Regul 47:2-9. 2007
  2. pmc Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway
    D Cefai
    Laboratoire d Immunologie Cellulaire et Tissulaire, Group Hospitalier GH Pitié Salpétrière, Paris, France
    J Clin Invest 86:2117-24. 1990
  3. ncbi Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat
    N J Haughey
    Department of Pharmacology and Therapeutics, University of Manitoba Faculty of Medicine, Winnipeg, Canada
    J Neurochem 73:1363-74. 1999
  4. ncbi Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1)
    A Caricasole
    Biology Department, GlaxoWellcome Medicines Research Centre, Verona, Italy
    Biochim Biophys Acta 1517:63-72. 2000
  5. pmc Phosphatidylcholine-specific phospholipase C activation is required for CCR5-dependent, NF-kB-driven CCL2 secretion elicited in response to HIV-1 gp120 in human primary macrophages
    Laura Fantuzzi
    Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
    Blood 111:3355-63. 2008
  6. pmc Protein kinase C phosphorylation of PLCβ1 regulates its cellular localization
    Omozuanvbo Aisiku
    Department of Physiology and Biophysics, Stony Brook University, Stony Brook, NY 11794 8661, USA
    Arch Biochem Biophys 509:186-90. 2011
  7. pmc Homozygous PLCB1 deletion associated with malignant migrating partial seizures in infancy
    Annapurna Poduri
    Department of Neurology, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Epilepsia 53:e146-50. 2012
  8. doi PLCβ isoforms differ in their subcellular location and their CT-domain dependent interaction with Gαq
    Merel J W Adjobo-Hermans
    Swammerdam Institute for Life Sciences, Section of Molecular Cytology, van Leeuwenhoek Centre for Advanced Microscopy, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands
    Cell Signal 25:255-63. 2013
  9. ncbi Phospholipase C-beta 1 is a GTPase-activating protein for Gq/11, its physiologic regulator
    G Berstein
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas 75235 9041
    Cell 70:411-8. 1992
  10. ncbi Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line
    G Zauli
    Institute of Human Anatomy, University of Ferrara, Italy
    Eur J Immunol 25:2695-700. 1995

Research Grants

  1. Steven A Lietman; Fiscal Year: 2015
  2. Molecular Mechanisms in Bone Resorption
    Steven A Lietman; Fiscal Year: 2012
  3. Activation of PI Specific Phospholipase C Enzymes
    MARY FEDARKO ROBERTS; Fiscal Year: 2013
  4. ROLE OF PHOSPHOLIPASE C IN T CELL ACTIVATION
    ROBERT GOLDFIEN; Fiscal Year: 1991
  5. IGA FC RECEPTORS
    JULIA PHILLIPS QUAGLIATA; Fiscal Year: 1993
  6. Enhancing axon regeneration by multi-inhibitor blocking
    RONALD SCHNAAR; Fiscal Year: 2005
  7. Membrane Rafts and Sertoli-Germ Cell Interactions
    SALLY NYQUIST; Fiscal Year: 2002
  8. PHOSPHOLIPASES AND THE PATHOGENESIS OF LISTERIA
    Howard Goldfine; Fiscal Year: 1993
  9. REGULATION OF PHOSPHOLIPASE C
    T Harden; Fiscal Year: 2002
  10. MECHANISTIC STUDIES OF PHOSPHOLIPID PHOSPHODIESTERASES
    Stephen Martin; Fiscal Year: 1999

Detail Information

Publications252 found, 100 shown here

  1. ncbi Nuclear inositide signaling: an appraisal of phospholipase C beta 1 behavior in myelodysplastic and leukemia cells
    Lucio Cocco
    Cellular Signalling Laboratory, Department of Anatomical Sciences, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Adv Enzyme Regul 47:2-9. 2007
  2. pmc Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway
    D Cefai
    Laboratoire d Immunologie Cellulaire et Tissulaire, Group Hospitalier GH Pitié Salpétrière, Paris, France
    J Clin Invest 86:2117-24. 1990
    ....
  3. ncbi Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat
    N J Haughey
    Department of Pharmacology and Therapeutics, University of Manitoba Faculty of Medicine, Winnipeg, Canada
    J Neurochem 73:1363-74. 1999
    ....
  4. ncbi Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1)
    A Caricasole
    Biology Department, GlaxoWellcome Medicines Research Centre, Verona, Italy
    Biochim Biophys Acta 1517:63-72. 2000
    ..Four mammalian isozymes are known (PLC beta 1-4), which differ in their function and expression patterns in vivo...
  5. pmc Phosphatidylcholine-specific phospholipase C activation is required for CCR5-dependent, NF-kB-driven CCL2 secretion elicited in response to HIV-1 gp120 in human primary macrophages
    Laura Fantuzzi
    Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
    Blood 111:3355-63. 2008
    ....
  6. pmc Protein kinase C phosphorylation of PLCβ1 regulates its cellular localization
    Omozuanvbo Aisiku
    Department of Physiology and Biophysics, Stony Brook University, Stony Brook, NY 11794 8661, USA
    Arch Biochem Biophys 509:186-90. 2011
    ..Our studies suggest that PKC phosphorylation regulates the level of PLCβ1 cytosolic and nuclear activity by regulating its cellular compartmentalization...
  7. pmc Homozygous PLCB1 deletion associated with malignant migrating partial seizures in infancy
    Annapurna Poduri
    Department of Neurology, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Epilepsia 53:e146-50. 2012
    ..homozygous deletion of chromosome 20p13, disrupting the promoter region and first three coding exons of the gene PLCB1. Additional MMPEI cases were screened for similar deletions or mutations in PLCB1 but did not harbor mutations...
  8. doi PLCβ isoforms differ in their subcellular location and their CT-domain dependent interaction with Gαq
    Merel J W Adjobo-Hermans
    Swammerdam Institute for Life Sciences, Section of Molecular Cytology, van Leeuwenhoek Centre for Advanced Microscopy, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands
    Cell Signal 25:255-63. 2013
    ..These findings suggest that under physiological circumstances, PLCβ3 and Gαq interact in a kiss-and-run fashion, likely due to the GTPase-activating activity of PLCβ towards Gαq...
  9. ncbi Phospholipase C-beta 1 is a GTPase-activating protein for Gq/11, its physiologic regulator
    G Berstein
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas 75235 9041
    Cell 70:411-8. 1992
    ..Such GAP activity by an effector coupled to a trimeric G protein can reconcile slow GTP hydrolysis by pure G proteins in vitro with fast physiologic deactivation of G protein-mediated signaling...
  10. ncbi Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line
    G Zauli
    Institute of Human Anatomy, University of Ferrara, Italy
    Eur J Immunol 25:2695-700. 1995
    ..The relevance of these findings for a better understanding of the biological functions of extracellular Tat is discussed...
  11. ncbi Identification and chromosomal localisation by fluorescence in situ hybridisation of human gene of phosphoinositide-specific phospholipase C beta(1)
    D Peruzzi
    Cellular Signalling Laboratory, Institute of Anatomy at the University of Bologna, Via Irnerio 48, I 40126, Bologna, Italy
    Biochim Biophys Acta 1484:175-82. 2000
    ....
  12. ncbi Determination of the contact energies between a regulator of G protein signaling and G protein subunits and phospholipase C beta 1
    L Dowal
    Department of Physiology and Biophysics, State University of New York at Stony Brook, Stony Brook, New York 11794 8661, USA
    Biochemistry 40:414-21. 2001
    ..Comparison of the relative affinities between these interacting proteins will ultimately allow us to determine whether certain complexes can form and where signals will be directed...
  13. ncbi Interleukin 2 activates nuclear phospholipase Cbeta by mitogen-activated protein kinase-dependent phosphorylation in human natural killer cells
    M Vitale
    Institute of Human Anatomy, University of Parma, Ospedale Maggiore, 14 43100 Parma, Italy
    FASEB J 15:1789-91. 2001
  14. pmc Induction of the Galpha(q) signaling cascade by the human immunodeficiency virus envelope is required for virus entry
    Brooke Harmon
    Division of Molecular Oncology, Washington University School of Medicine, St Louis, Missouri, USA
    J Virol 82:9191-205. 2008
    ..These results could provide a new focus for therapeutic intervention with drugs targeting host signaling mediators rather than viral molecules, a strategy which is less likely to result in resistance...
  15. doi Phosphatidic acid regulates signal output by G protein coupled receptors through direct interaction with phospholipase C-beta(1)
    Irene Litosch
    Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, Florida 33101, USA
    Cell Signal 21:1379-84. 2009
    ..Galpha(q) and PA may co-ordinate to regulate signaling. Regulation by PA may constitute part of a mechanism that routes receptor signaling to specific PLC isoforms...
  16. pmc Activation of host phospholipases C and D in macrophages after infection with Listeria monocytogenes
    H Goldfine
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6076, USA
    Infect Immun 68:5735-41. 2000
    ..Pretreatment of J774 cells with the PLD inhibitor, 2, 3-diphosphoglycerate partially inhibited escape of the bacteria from the primary phagocytic vacuole...
  17. ncbi Activation of phosphatidylinositol-specific phospholipase C by HDL-associated lysosphingolipid. Involvement in mitogenesis but not in cholesterol efflux
    J R Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat, Munster, Germany
    Biochemistry 39:15199-207. 2000
    ..Apo A-I stimulates phosphatidylcholine breakdown and thereby facilitates cholesterol efflux, whereas LSF and SPC trigger PI-PLC activation and thereby stimulate cell proliferation...
  18. ncbi Detection of multiple virulence-associated genes in Listeria monocytogenes isolated from bovine mastitis cases
    D B Rawool
    Division of Veterinary Public Health, Indian Veterinary Research Institute, Izatnagar 243 122, India
    Int J Food Microbiol 113:201-7. 2007
    ..monocytogenes and plcA, prfA and actA genes for L. ivanovii) hold a good promise as rapid and reliable in vitro alternatives to in vivo pathogenicity tests...
  19. ncbi Evaluation and interlaboratory validation of a selective agar for phosphatidylinositol-specific phospholipase C activity using a chromogenic substrate to detect Listeria monocytogenes from foods
    Karen C Jinneman
    Food and Drug Administration, Office of Regulatory Affairs, Pacific Regional Laboratory Northwest, 22201 23rd Drive S E, Bothell, Washington 98021, USA
    J Food Prot 66:441-5. 2003
    ..3, 99.2, and 90.2%, respectively. In statistical analyses of the different combinations of agars, the OXF-BCM and BCM-PAL combinations were found to be superior to the OXF-PAL combination for the detection of L. monocytogenes...
  20. pmc Gangliosides and Nogo receptors independently mediate myelin-associated glycoprotein inhibition of neurite outgrowth in different nerve cells
    Niraj R Mehta
    Department of Pharmacology, The Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 282:27875-86. 2007
    ..Our data indicate that MAG inhibits axon outgrowth via two independent receptors, gangliosides and NgRs...
  21. pmc Genetic and biochemical characterization of a phosphatidylinositol-specific phospholipase C in Saccharomyces cerevisiae
    J S Flick
    Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Mol Cell Biol 13:5861-76. 1993
    ..The findings reported here suggest that hydrolysis of PIP2 in S. cerevisiae is required for a number of nutritional and stress-related responses...
  22. ncbi Crystal structure of phosphatidylinositol-specific phospholipase C from Bacillus cereus in complex with glucosaminyl(alpha 1-->6)-D-myo-inositol, an essential fragment of GPI anchors
    D W Heinz
    Institut fur Organische Chemie und Biochemie, Universitat Freiburg, Germany
    Biochemistry 35:9496-504. 1996
    ..cereus PI-PLC. This explains why B. cereus PI-PLC can cleave GPI anchors having variable glycan structures...
  23. pmc The biological significance of phospholipase C beta 1 gene mutation in mouse sperm in the acrosome reaction, fertilization, and embryo development
    D Choi
    Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, IVF Clinic, Samsung Medical Center, Seoul, Korea
    J Assist Reprod Genet 18:305-10. 2001
    ..We carried out this study to evaluate the biological significance of phospholipase C beta 1 gene mutation in mouse sperm in the acrosome reaction, fertilization, and embryo development...
  24. ncbi G beta gamma mediates the interplay between tubulin dimers and microtubules in the modulation of Gq signaling
    Juliana S Popova
    Department of Physiology and Biophysics, College of Medicine, University of Illinois, Chicago, Illinois 60612 7342, USA
    J Biol Chem 278:34299-308. 2003
    Agonist stimulation causes tubulin association with the plasma membrane and activation of PLC beta 1 through direct interaction with, and transactivation of, G alpha q...
  25. ncbi Characterization of G protein-coupled receptors expressed by ECV304 human endothelial cells
    J Howl
    University of Wolverhampton, School of Health Sciences, UK
    Endothelium 6:23-32. 1998
    ..receptors, P2U-purinoceptors and lysophosphatidic acid receptors which are functionally coupled to phosphoinositidase C. G protein-coupled receptors which bind adenosine (A2 receptor), calcitonin, and adrenaline (beta-..
  26. pmc Allosteric activation of the extracellular Ca2+-sensing receptor by L-amino acids enhances ERK1/2 phosphorylation
    Heather J Lee
    School of Molecular and Microbial Biosciences, University of Sydney, Sydney, NSW 2006, Australia
    Biochem J 404:141-9. 2007
    ....
  27. ncbi Phosphatidic acid is the prominent product of endogenous neuronal nuclear lipid phosphorylation, an activity enhanced by sphingosine, linked to phospholipase C and associated with the nuclear envelope
    R R Baker
    Department of Biochemistry, Room 5202, Medical Sciences Bldg, University of Toronto, Toronto, ON M5S 1A8, Canada
    Biochim Biophys Acta 1534:110-20. 2001
    ..b>Phosphoinositidase C was present in the nuclei and inhibitors of this enzyme did decrease PA formation, indicating ..
  28. ncbi Phosphorothiolate analogues of phosphatidylinositols as assay substrates for phospholipase C
    Yinghui Liu
    Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago IL 60612, USA
    Chembiochem 8:1430-9. 2007
    ..In addition, the binding affinities of all four substrate types were found to be quite similar; this indicates that the energy of enzyme interaction with the 4-phosphate group is directed almost entirely to catalysis...
  29. ncbi Incorporation of ethanolamine into insulin-sensitive glycosylated phosphatidylinositol of chick embryo fibroblasts
    M Kajiyoshi
    Department of Pathological Biochemistry, Medical Research Institute, Medical and Dental University, Kandasurugadai, Chiyoda ku, 2 3 10, Tokyo 101 0062, Japan
    Biochim Biophys Acta 1488:255-67. 2000
    ..The results indicate that peak I lipid contains primary ethanolamine as a glycan component and is insulin-sensitive free GPI...
  30. pmc Conversion of raft associated prion protein to the protease-resistant state requires insertion of PrP-res (PrP(Sc)) into contiguous membranes
    Gerald S Baron
    Laboratory of Persistent Viral Diseases, NIAID, NIH, Rocky Mountain Laboratories, 903 South 4th Street, Hamilton, MT 59840, USA
    EMBO J 21:1031-40. 2002
    ....
  31. ncbi Activation of human neutrophils by soluble immune complexes: role of Fc gamma RII and Fc gamma RIIIb in stimulation of the respiratory burst and elevation of intracellular Ca2+
    S W Edwards
    School of Biological Sciences, University of Liverpool, United Kingdom
    Ann N Y Acad Sci 832:341-57. 1997
    ....
  32. ncbi Chlorpromazine inhibits the glucocorticoid receptor-mediated gene transcription in a calcium-dependent manner
    A Basta-Kaim
    Department of Endocrinology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343 Krakow, Poland
    Neuropharmacology 43:1035-43. 2002
    ..The inhibitory effect of chlorpromazine on the corticosterone-induced gene transcription seems to depend on the inhibition of Ca(2+) influx and/or the inhibition of some calcium-dependent enzymes, e.g. phospholipase beta(1)...
  33. ncbi Regulation of phospholipase C-beta activity by phosphatidic acid: isoform dependence, role of protein kinase C, and G protein subunits
    Irene Litosch
    Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Florida 33101, USA
    Biochemistry 42:1618-23. 2003
    ..PA may be an important component of a receptor mediated signaling mechanism that determines PLC-beta(1) activation...
  34. pmc Thromboxane-insensitive dog platelets have impaired activation of phospholipase C due to receptor-linked G protein dysfunction
    G J Johnson
    Department of Medicine, Veterans Administration Medical Center, Minneapolis, Minnesota 55417
    J Clin Invest 92:2469-79. 1993
    ..Thus, TXA2- dog platelets have impaired PI-PLC activation in response to TXA2/PGH2 receptor agonists secondary to G protein dysfunction, presumably involving a member of the Gq class...
  35. ncbi Application of capillary electrophoresis to determination of enzyme activity and other properties of phosphatidylinositol-specific phospholipase C
    M J Suh
    Doping Control Center, Korea Institute of Science and Technology, Seoul, South Korea
    J Chromatogr A 781:263-70. 1997
    ....
  36. ncbi Fuel and hormone regulation of phospholipase C beta 1 and delta 1 overexpressed in RINm5F pancreatic beta cells
    G G Kelley
    Department of Medicine, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    Mol Cell Endocrinol 177:107-15. 2001
    ..Previous studies have suggested that glucose may couple to PLC beta 1 and PLC delta 1...
  37. pmc Ecto-5'-nucleotidase and intestinal ion secretion by enteropathogenic Escherichia coli
    John K Crane
    Department of Medicine, Division of Infectious Diseases, University at Buffalo, Room 317 Biomedical Research Bldg, 3435 Main St, Buffalo, NY, 14214, USA
    Purinergic Signal 3:233-46. 2007
    ....
  38. ncbi Bradykinin- and thrombin-induced increases in endothelial permeability occur independently of phospholipase C but require protein kinase C activation
    J L Aschner
    Department of Pediatrics, Bowman Gray School of Medicine of Wake Forest University, Winston Salem, North Carolina 27157 1081, USA
    J Cell Physiol 173:387-96. 1997
    ....
  39. ncbi Functional demonstration of surface carbonic anhydrase IV activity on rat astrocytes
    Nataliya Svichar
    Department of Neurosurgery, New York University School of Medicine, New York, New York 10016, USA
    Glia 53:241-7. 2006
    ..Thus, our data collectively document the presence of CAIV on the surface of brain astrocytes, and suggest that this is the predominant CA isoform on these cells...
  40. pmc Bile acid reflux contributes to development of esophageal adenocarcinoma via activation of phosphatidylinositol-specific phospholipase Cgamma2 and NADPH oxidase NOX5-S
    Jie Hong
    Department of Medicine, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
    Cancer Res 70:1247-55. 2010
    ....
  41. doi Phospholipase C beta 1 deficiency is associated with early-onset epileptic encephalopathy
    Manju A Kurian
    Department of Medical and Molecular Genetics, University of Birmingham School of Medicine, Institute of Biomedical Research, Birmingham, UK
    Brain 133:2964-70. 2010
    ..Although phospholipase C-β 1 deficiency has not previously been reported in humans, the Plcb1 homozygote knockout mouse displays early-onset severe tonic seizures and growth retardation, thus recapitulating ..
  42. ncbi Effects of scalaradial, a novel inhibitor of 14 kDa phospholipase A2, on human neutrophil function
    M S Barnette
    Department of Inflammation and Respiratory Pharmacology, SmithKline Beecham Laboratories, King of Prussia, PA 19406
    Biochem Pharmacol 47:1661-7. 1994
    ....
  43. ncbi Probing the roles of active site residues in phosphatidylinositol-specific phospholipase C from Bacillus cereus by site-directed mutagenesis
    C S Gassler
    Institut fur Organische Chemie und Biochemie, Universitat Freiburg, D 79104 Freiburg, Germany
    Biochemistry 36:12802-13. 1997
    ....
  44. ncbi Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2
    D Park
    Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 267:16048-55. 1992
    ..see also accompanying article (Lee, C. H., Park, D., Wu, D., Rhee, S. G., and Simon, M. I. (1992) J. Biol. Chem. 267, 16044-16047)...
  45. pmc Mechanisms of leukotriene D4-induced constriction in human small bronchioles
    V A Snetkov
    Department of Respiratory Medicine and Allergy, Guy s, King s and St Thomas School of Medicine, King s College London, Guy s Campus, London SE1 9RT
    Br J Pharmacol 133:243-52. 2001
    ..We conclude that LTD4 causes constriction of these small bronchioles primarily by activating Ca2+ entry via non-voltage gated channels, possibly by a PC-PLC mediated pathway...
  46. ncbi Antidepressants reduce phosphoinositide-specific phospholipase C (PI-PLC) activity and the mRNA and protein expression of selective PLC beta 1 isozyme in rat brain
    Y Dwivedi
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 W Taylor St, Chicago, IL 60612, USA
    Neuropharmacology 43:1269-79. 2002
    ..Our results thus suggest that modulation of PI-PLC may be common to all classes of antidepressants, which in turn, may be associated with their mechanisms of action...
  47. ncbi The role of phospholipase C and phosphatidylinositol 3-kinase in vascular smooth muscle cell migration and proliferation
    Bo Liu
    Department of Surgery, Division of Vascular Surgery, New York Presbyterian Hospital and Weill Medical College of Cornell University, 525 East 68th Street, Payson 707, New York, NY 1002, USA
    J Surg Res 120:256-65. 2004
    ..In this study, we investigate the role of PLC and PI3-K in platelet-derived growth factor (PDGF) and extracellular matrix protein (ECM) induced SMC proliferation and migration...
  48. pmc Phospholipase C beta3 is a key component in the Gbetagamma/PKCeta/PKD-mediated regulation of trans-Golgi network to plasma membrane transport
    Alberto M Díaz Añel
    Center for Molecular Genetics, University of California at San Diego, San Diego, CA, USA
    Biochem J 406:157-65. 2007
    ..In conclusion, we demonstrate that fission of transport carriers at the TGN is dependent on PI-PLCs, specifically PLCbeta3, which is necessary to activate PKCeta and PKD in that Golgi compartment, via DAG production...
  49. ncbi Expression of glycophosphatidylinositol-anchored and -non-anchored isoforms of vascular cell adhesion molecule 1 in murine stromal and endothelial cells
    T Kinashi
    Center for Blood Research, Harvard Medical School, Boston, Massachusetts 02115
    J Leukoc Biol 57:168-73. 1995
    ..The GPI-anchored isoform is functionally important, because on a cell on which it was expressed almost as well as the 100 kDa isoform, treatment with PI-PLC reduced VLA-4-dependent conjugate formation...
  50. ncbi Effects of pertussis toxin on extracellular signal-regulated kinase activation in hepatocytes by hormones and receptor-independent agents: evidence suggesting a stimulatory role of G(i) proteins at a level distal to receptor coupling
    O Melien
    Department of Pharmacology, Faculty of Medicine, University of Oslo, Blindern, Oslo, Norway
    J Cell Physiol 184:27-36. 2000
    ....
  51. pmc Activation of phospholipase D by metabotropic glutamate receptor agonists in rat cerebrocortical synaptosomes
    T Shinomura
    Department of Pharmacology and Neuroscience, Ninewells Hospital Medical School, University of Dundee, Dundee, DD1 9SY
    Br J Pharmacol 131:1011-8. 2000
    ..These data suggest that, in rat cerebrocortical synaptosomes, the 1S,3R-ACPD-sensitive mGluR is coupled to PLD through a mechanism that is independent of both PKC and PI-PLC...
  52. ncbi Phospholipase C expression and activity in smooth muscle cells of renal arterioles and aorta of young, spontaneously hypertensive rats during culture
    Zhangping Peng
    Department of Cell and Molecular Physiology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7545, USA
    Am J Hypertens 20:520-6. 2007
    ..We assessed the stability of variables over passages 3 to 11...
  53. ncbi The phosphoinositide-phospholipase C (PI-PLC) pathway in the mouse oocyte
    Brigitte Lefevre
    INSERM U566 CEA DRR LGAG Univ Paris 7, Batiment 05, Route du Panorama, F 92260, Fontenay aux Roses, France
    Crit Rev Eukaryot Gene Expr 17:259-69. 2007
    ..Phospholipase C beta1 (PLC beta 1) is first exclusively localized to the nucleus and then migrates to the cytoplasm when the oocyte is fully grown...
  54. pmc Correlation of vesicle binding and phospholipid dynamics with phospholipase C activity: insights into phosphatidylcholine activation and surface dilution inhibition
    Mingming Pu
    Boston College, Chestnut Hill, Massachusetts 02467, USA
    J Biol Chem 284:16099-107. 2009
    ..Both methodologies provide a detailed view of protein-lipid interactions and can be readily adapted for other peripheral membrane proteins...
  55. pmc Cyclic GMP regulates activation of phosphoinositidase C by bradykinin in sensory neurons
    J S Harvey
    Sandoz Institute for Medical Research, London, U K
    Biochem J 316:539-44. 1996
    ..ganglion (DRG) neurons to bradykinin resulted in marked attenuation of bradykinin-induced activation of phosphoinositidase C (PIC)...
  56. ncbi The human muscarinic M1 acetylcholine receptor, when express in CHO cells, activates and downregulates both Gq alpha and G11 alpha equally and non-selectively
    I Mullaney
    Department of Biochemistry, University of Glasgow, Scotland, UK
    FEBS Lett 324:241-5. 1993
    CHO cells express both of the phosphoinositidase C-linked G-proteins Gq and G11. G11 alpha is some 2.5-fold more highly expressed than Gq alpha in membranes of these cells...
  57. ncbi Osmotic stress activates phosphatidylinositol-3,5-bisphosphate synthesis
    S K Dove
    Centre for Clinical Research in Immunology and Signalling, University of Birmingham, UK
    Nature 390:187-92. 1997
    ..Two widespread eukaryotic phosphoinositide-based signal transduction mechanisms, phosphoinositidase C-catalysed phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) hydrolysis and 3-OH kinase-catalysed PtdIns(..
  58. ncbi Crystal structure of the phosphatidylinositol-specific phospholipase C from the human pathogen Listeria monocytogenes
    J Moser
    Institut fur Organische Chemie und Biochemie, Universitat Freiburg, Germany
    J Mol Biol 273:269-82. 1997
    ..The active site pocket is also well conserved with only two amino acid replacements directly implicated in inositol binding...
  59. ncbi Glycosylphosphatidylinositol-anchored proteins play an important role in the biogenesis of the Alzheimer's amyloid beta-protein
    K Sambamurti
    Mayo Clinic, Jacksonville, Florida 32224, USA
    J Biol Chem 274:26810-4. 1999
    ..The cell-surface GPI-anchored protein(s) involved in Abeta biogenesis may be excellent therapeutic target(s) in Alzheimer's disease...
  60. ncbi Alteration of phosphoinositide degradation by cytosolic and membrane-bound phospholipases after forebrain ischemia-reperfusion in gerbil: effects of amyloid beta peptide
    J Strosznajder
    Department of Cellular Signalling, Medical Research Centre, Polish Academy of Sciences, Warszawa
    Neurochem Res 24:1277-84. 1999
    ..Ischemia-reperfusion injury had no effect on Abeta-evoked alterations of synaptic plasma membrane-bound PI-PLC...
  61. ncbi Mechanism of radiation-induced diacylglycerol production in primary cultured rat hepatocytes
    T Nakajima
    Division of Biology and Oncology, National Institute of Radiological Sciences, Chiba shi, Japan
    J Radiat Res 40:135-44. 1999
    ..These results suggest that radiation exerts PI-PLC activation through hydroxyl radical generation, followed by diacylglycerol production and PKC activation...
  62. ncbi Tri-dimensional prostate cell cultures in simulated microgravity and induced changes in lipid second messengers and signal transduction
    S Clejan
    Department of Pathology and Laboratory Medicine, Tulane University Health Science Center, 1430 Tulane Ave, SL 79, New Orleans, LA 70112 2699, USA
    J Cell Mol Med 5:60-73. 2001
    ....
  63. ncbi Effect of glycosylphosphatidylinositol anchor-dependent and -independent prion protein association with model raft membranes on conversion to the protease-resistant isoform
    Gerald S Baron
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, NIAID, National Institutes of Health, Hamilton, Montana 59840, USA
    J Biol Chem 278:14883-92. 2003
    ..Thus, of the two forms of raft membrane association by PrP-sen, only the GPI anchor-directed form resists conversion induced by exogenous PrP-res...
  64. ncbi New aspects of formation of 1,2-cyclic phosphates by phospholipase C-delta1
    Yinghui Liu
    Department of Medicinal Chemistry and Pharmacognosy MC 781, University of Illinois at Chicago, Chicago, IL 60612, USA
    Bioorg Med Chem 11:2471-5. 2003
    ..The potential significance of the cyclic products in the signaling pathways is also discussed...
  65. ncbi 1alpha,25(OH)2D3 causes a rapid increase in phosphatidylinositol-specific PLC-beta activity via phospholipase A2-dependent production of lysophospholipid
    Z Schwartz
    Department of Biomedical Engineering, Georgia Institute of Technology, 315 Ferst Drive, Atlanta, GA 30332, USA
    Steroids 68:423-37. 2003
    ..Antibodies to PLC-beta1 and PLC-beta3 blocked the 1alpha,25(OH)(2)D(3) effect; antibodies to PLC-delta and PLC-gamma did not. Thus, 1alpha,25(OH)(2)D(3) regulates PLC-beta through PLA(2)-dependent production of lysophospholipid...
  66. ncbi Water-miscible organic cosolvents enhance phosphatidylinositol-specific phospholipase C phosphotransferase as well as phosphodiesterase activity
    Hania Wehbi
    Department of Chemistry, E F Merkert Chemistry Center, Boston College, 2609 Beacon Street, Chestnut Hill, MA 02167, USA
    Biochim Biophys Acta 1613:15-27. 2003
    ....
  67. ncbi Involvement of nuclear phosphatidylinositol-dependent phospholipases C in cell cycle progression during rat liver regeneration
    Elisabetta Albi
    Department of Biochemical Sciences and Molecular Biotechnology, Physiopathology, Policlinico Monteluce, Perugia, Italy
    J Cell Physiol 197:181-8. 2003
    ..The increased activity of PI-PLC beta(1) constitutively present within the hepatocyte nucleus, should trigger DNA replication, whereas PI-PLC gamma(1) should be involved in G2/M phase transition through lamin phosphorylation...
  68. ncbi The Vr-PLC3 gene encodes a putative plasma membrane-localized phosphoinositide-specific phospholipase C whose expression is induced by abiotic stress in mung bean (Vigna radiata L.)
    Yun Ju Kim
    Department of Biology, College of Science, Yonsei University, 120 749, Seoul, South Korea
    FEBS Lett 556:127-36. 2004
    ..The C2 domain was essential for Vr-PLC3 to be targeted to the plasma membrane. The possible biological functions of stress-responsive Vr-PLC3 in mung bean plants are discussed...
  69. ncbi Isolation of cDNAs encoding typical and novel types of phosphoinositide-specific phospholipase C from the moss Physcomitrella patens
    Koji Mikami
    National Institute for Basic Biology, 38 Nishigonaka, Myodaiji, Okazaki 444 8585, Japan
    J Exp Bot 55:1437-9. 2004
    ..Furthermore, at millimolar Ca2+, phosphatidylinositol was hydrolysed by PpPLC2, but not by PpPLC1. Thus, PpPLC1 and PpPLC2 are typical and novel types of plant PI-PLC, respectively...
  70. ncbi Epidermal growth factor modulates prostate cancer cell invasiveness regulating urokinase-type plasminogen activator activity. EGF-receptor inhibition may prevent tumor cell dissemination
    Claudio Festuccia
    Department of Experimental Medicine, L Aquila, Italy
    Thromb Haemost 93:964-75. 2005
    ....
  71. pmc Targeting of protein kinase C-epsilon during Fcgamma receptor-dependent phagocytosis requires the epsilonC1B domain and phospholipase C-gamma1
    Keylon L Cheeseman
    Center for Cell Biology and Cancer Research, Albany Medical College, Albany, NY 12208, USA
    Mol Biol Cell 17:799-813. 2006
    ..Together, these results support a model in which PI-PLC-gamma1 provides DAG that binds to epsilonC1B, facilitating PKC-epsilon localization to phagosomes for efficient IgG-mediated phagocytosis...
  72. ncbi Phosphoinositide-specific phospholipase C (PI-PLC) beta1 and nuclear lipid-dependent signaling
    Lucio Cocco
    Cellular Signalling Laboratory, Department of Human Anatomical Sciences, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Biochim Biophys Acta 1761:509-21. 2006
    ..This review aims at highlighting the most significant and up-dated findings about phosphoinositide-specific phospholipase C beta(1) in the nucleus...
  73. pmc The complement regulatory proteins CD55 (decay accelerating factor) and CD59 are expressed on the inner acrosomal membrane of human spermatozoa as well as CD46 (membrane cofactor protein)
    J A Cummerson
    Division of Immunology, School of Infection and Host Defence, University of Liverpool, Liverpool, UK
    Immunology 118:333-42. 2006
    ..Antibody-induced membrane rafting and release of CD55 & CD59 in vitro may have influenced previous results. Significant coexpression of CD55 & CD46 on the IAM suggests some functional cooperation at this site...
  74. ncbi Molecular defects in the ABCA1 pathway affect platelet function
    Gerd Schmitz
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Germany
    Pathophysiol Haemost Thromb 35:166-74. 2006
    ..It is concluded that the presence of ABCA1 and ABCG1 in the AP-3 pathway will have major impact for membrane phospholipid processing and HDL metabolism and their relation to disorders of lysosome-related organelles...
  75. ncbi Modulation of ERK 1/2 and p38 MAPK signaling pathways by ATP in osteoblasts: involvement of mechanical stress-activated calcium influx, PKC and Src activation
    S Katz
    Departamento de Biologia, Bioquimica y Farmacia, Universidad Nacional del Sur, San Juan 670, B8000ICN Bahia Blanca, Argentina
    Int J Biochem Cell Biol 38:2082-91. 2006
    ..This effect also involves upstream mediators such as PI-PLC, PKC and Src family kinases...
  76. ncbi Structural determinants for phosphatidic acid regulation of phospholipase C-beta1
    Elliott M Ross
    Department of Molecular and Cellular Pharmacology, University of Miami, Miller School of Medicine, Miami, Florida 33101, USA
    J Biol Chem 281:33087-94. 2006
    ..PA regulation of PLC-beta(1) requires unique residues that are not required for Galpha(q) stimulation or GTPase-activating protein activity...
  77. ncbi Expression of phosphoinositide-specific phospholipase C isoenzymes in cultured astrocytes
    Vincenza Rita Lo Vasco
    Department of Fisiologia e Farmacologia V Erspamer, Respiratorie e Morfologiche, University of Rome La Sapienza, Rome, Italy
    J Cell Biochem 100:952-9. 2007
    ..In particular while some isoenzymes (namely isoforms beta3 and beta4) resulted mainly nuclear, others (isoforms delta4 and epsilon) were preferentially localized at cytoplasmic and plasma membrane level...
  78. ncbi Nuclear phospholipase C beta1 and cellular differentiation
    Irene Faenza
    Cellular Signaling Laboratory, Department of Anatomical Sciences, University of Bologna, 40126 Bologna, Italy
    Front Biosci 13:2452-63. 2008
    ..In this report we will focus on the signal transduction-related metabolism of nuclear PI and review the most convincing evidence that the PI cycle is involved in differentiation programs in several cell systems...
  79. pmc The alpha2delta subunits of voltage-gated calcium channels form GPI-anchored proteins, a posttranslational modification essential for function
    Anthony Davies
    Department of Neuroscience, Physiology and Pharmacology, University College, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 107:1654-9. 2010
    ..In conclusion, this study redefines our understanding of alpha(2)delta subunits, both in terms of their role in calcium-channel function and other roles in synaptogenesis...
  80. pmc Developmental expression of a Trypanosoma cruzi phosphoinositide-specific phospholipase C in amastigotes and stimulation of host phosphoinositide hydrolysis
    Vicente de Paulo Martins
    Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602 2607, USA
    Infect Immun 78:4206-12. 2010
    ..The presence of TcPI-PLC on the outer surface of the plasma membrane of the parasite and the capacity to be secreted and to alter host phospholipids are novel mechanisms of the host-parasite interaction...
  81. pmc SH3BP2 mutations potentiate osteoclastogenesis via PLCγ
    Steven A Lietman
    Department of Orthopaedic Surgery, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio 44195, USA
    J Orthop Res 28:1425-30. 2010
    ..The consequent activation of calcineurin and NFAT proteins induces the excessive osteoclastic phenotype of cherubism...
  82. doi Role of phosphoinositide-specific phospholipase C η2 in isolated and syndromic mental retardation
    Vincenza Rita Lo Vasco
    Department of Organi di Senso, University of Rome Sapienza, Italy
    Eur Neurol 65:264-9. 2011
    ..For its role in the nervous system, PI-PLC η2 might be a putative candidate gene for the neurodevelopmental delay observed in patients bearing 1p36.3 deletions...
  83. doi Vasopressin, ATP and catecholamines differentially control potassium secretion in inner ear cell line
    Jérôme Nevoux
    UMR S 867, INSERM, UFR de Médecine Paris Diderot, Paris, France
    FEBS Lett 585:2703-8. 2011
    ..the presence of vasopressin, catecholamine and purinergic signaling pathways, coupled to adenylate cyclase, phosphoinositidase C and Ca(2+) activation...
  84. doi Glycosyl-phosphatidylinositol (GPI)-anchored membrane association of the porcine reproductive and respiratory syndrome virus GP4 glycoprotein and its co-localization with CD163 in lipid rafts
    Yijun Du
    Department of Pathobiology, University of Illinois at Urbana Champaign, Urbana, IL 61802, USA
    Virology 424:18-32. 2012
    ..Since CD163 has been reported as a cellular receptor for PRRSV and GP4 has been shown to interact with this receptor, our data implicates an important role of lipid rafts during entry of the virus...
  85. doi Medicago truncatula DNF2 is a PI-PLC-XD-containing protein required for bacteroid persistence and prevention of nodule early senescence and defense-like reactions
    Marie Bourcy
    Institut des Sciences du Vegetal, CNRS, Gif sur Yvette, France
    New Phytol 197:1250-61. 2013
    ..Furthermore, mutant nodules senesce rapidly and exhibit defense-like reactions. This atypical phenotype amongst Fix(-) mutants unravels dnf2 as a new actor of bacteroid persistence inside symbiotic plant cells...
  86. doi Expression changes and bioinformatic analysis of Wallerian degeneration after sciatic nerve injury in rat
    Dengbing Yao
    Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, 226019, China
    Neurosci Bull 29:321-32. 2013
    ..Some key factors were NGF, MAG, CNTF, CTNNA2, p53, JAK2, PLCB1, STAT3, BDNF, PRKC, collagen II, FGF, THBS4, TNC and c-Src, which were further validated by real-time quantitative ..
  87. doi Lack of pathogenic mutations in six patients with MMPSI
    Maria Rosaria De Filippo
    Laboratory of Molecular Medicine and Genomics, Department of Medicine and Surgery, University of Salerno, Baronissi, Italy Fondazione IRCCS SDN, 80143 Napoli, Italy
    Epilepsy Res 108:340-4. 2014
    Sequencing of the KCNT1, PLCB1, SCN1A and TBC1D24 loci was performed in six children with typical features of malignant migrating partial seizures of infancy (MMPSI), to verify the presence of potential disease-causing mutations, ..
  88. pmc PLC-beta 1 regulates the expression of miR-210 during mithramycin-mediated erythroid differentiation in K562 cells
    Alberto Bavelloni
    SC Laboratory of Musculoskeletal Cell Biology, Rizzoli Orthopedic Institute, Bologna, Italy Laboratory RAMSES, Rizzoli Orthopedic Institute, Bologna, Italy
    Oncotarget 5:4222-31. 2014
    ....
  89. doi PLCβ1a and PLCβ1b selective regulation and cyclin D3 modulation reduced by kinamycin F during k562 cell differentiation
    Alberto Bavelloni
    SC Laboratory of Musculoskeletal Cell Biology, Rizzoli Orthopedic Institute, Bologna, Italy Laboratory RAMSES, Rizzoli Orthopedic Institute, Bologna, Italy
    J Cell Physiol 230:587-94. 2015
    ..Our data indicate that the amplification of PLCβ1a expression, following treatment with kinamycin F, confers a real advantage to K562 cells viability and protects cells themselves from apoptosis...
  90. doi Orexin-A differentially modulates AMPA-preferring responses of ganglion cells and amacrine cells in rat retina
    Chao Zheng
    Institute of Neurobiology, Institutes of Brain Science, State Key Laboratory of Medical Neurobiology and Collaborative Innovation Center for Brain Science, Fudan University, 138 Yixueyuan Road, Shanghai 200032, China Cell Electrophysiology Laboratory, Wannan Medical College, 22 West Wenchang Road, Wuhu, Anhui 241002, China
    Neuropharmacology 93:80-93. 2015
    ..These two actions of orexin-A, while working in concert, provide a characteristic way for modulating information processing in the inner retina. ..
  91. doi Participation of PLA2 and PLC in DhL-induced activation of Rhinella arenarum oocytes
    J Zapata-Martínez
    Departamento de Biología del Desarrollo INSIBIO, Chacabuco 461, 4000 San Miguel de Tucuman, Argentina
    Zygote 24:495-501. 2016
    ..Results would indicate that DhL induces activation of in vitro matured oocytes of Rhinella arenarum by activation of IP-PLC, which in turn may induce IP3 formation which produces Ca2+ release. ..
  92. doi PLCB1 epileptic encephalopathies; Review and expansion of the phenotypic spectrum
    An Sofie Schoonjans
    Department of Neurology Pediatric Neurology, University and University Hospital Antwerp, Antwerp, Belgium Electronic address
    Eur J Paediatr Neurol 20:474-9. 2016
    Biallelic loss-of-function mutations of phospholipase C-β1 (PLCB1) have been described in three children with an early onset epileptic encephalopathy (EE)...
  93. ncbi Selective Activation of Nuclear PI-PLCbeta1 During Normal and Therapy-Related Differentiation
    Sara Mongiorgi
    Cellular Signalling Laboratory, Department of Biomedical and Neuromotor Sciences, University of Bologna, Via Irnerio 48, 40126, Bologna, Italy
    Curr Pharm Des 22:2345-8. 2016
    ....
  94. pmc Signaling mechanism for modulation by ATP of glycine receptors on rat retinal ganglion cells
    Ping Ping Zhang
    Institutes of Brain Science, State Key Laboratory of Medical Neurobiology and Collaborative Innovation Center for Brain Science, Fudan University, 138 Yixueyuan Road, Shanghai 200032, China
    Sci Rep 6:28938. 2016
    ..These results suggest that ATP may modify the ON-to-OFF crossover inhibition, thus changing action potential patterns of OFF-GCs. ..
  95. ncbi Purification and cDNA cloning of bovine liver 5'-nucleotidase, a GPI-anchored protein, and its expression in COS cells
    K Suzuki
    Department of Microbial Chemistry, Faculty of Pharmaceutical Sciences, Nagoya City University
    J Biochem 113:607-13. 1993
    ..PI-PLC released 45% of the transiently expressed 5'-nucleotidase activity, indicating that the cDNA isolated here encodes this enzyme expressed as a GPI-anchored protein...
  96. ncbi Purification of a novel phospholipase C isozyme from bovine cerebellum
    D S Min
    Department of Life Science, Pohang Institute of Science and Technology, Hyoja Dong, Korea
    J Biol Chem 268:12207-12. 1993
    ..Thus, we have designated this enzyme PLC-beta 4...
  97. ncbi Molecular characterization of a glycosylphosphatidylinositol-linked ADP-ribosyltransferase from lymphocytes
    I J Okazaki
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1434, USA
    Blood 88:915-21. 1996
    ..Thus, we have cloned a novel gene that has properties identical to the transferase detected in CTL, and may be involved in the NAD-dependent regulation of proliferation and cytotoxicity...
  98. ncbi Phospholipases involved in lysophosphatidylinositol metabolism in rat brain
    T Kobayashi
    Department of Biological Chemistry, Faculty of Pharmaceutical Sciences, Nagoya City University, Japan
    J Lipid Mediat Cell Signal 14:33-7. 1996
    ..These findings suggest possible pathways for PI metabolism through lysoPI to yield monoacylglycerol (mainly 2-arachidonoyl glycerol) and inositolphosphates in the brain, which are different from the well-characterized PI-PLC pathway...
  99. ncbi AtPLC2, a gene encoding phosphoinositide-specific phospholipase C, is constitutively expressed in vegetative and floral tissues in Arabidopsis thaliana
    T Hirayama
    Laboratory of Plant Molecular Biology, The Institute of Physical and Chemical Research RIKEN, Tsukuba, Ibaraki, Japan
    Plant Mol Biol 34:175-80. 1997
    ..The AtPLC2 mRNA was detected in vegetative and floral tissues. We determined the positions of these two PI-PLCs genes on Arabidopsis chromosomes by RFLP mapping using P1 genomic clones...
  100. ncbi Efficacy of fluvoxamine in preventing relapse in alcohol dependence: a one-year, double-blind, placebo-controlled multicentre study with analysis by typology
    Jonathan Chick
    Department of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh EH10 5HF, Scotland, UK
    Drug Alcohol Depend 74:61-70. 2004
    ..Tridimensional Personality Questionnaire, Types I and II had similar rates of survival without relapse on placebo (PLC I: 19.3%, n = 135; PLC II: 18.2%, n = 110), but on fluvoxamine Type II did worse than Type I (FLU I: 13...
  101. ncbi Phosphatidylinositol-specific phospholipase C of Bacillus anthracis down-modulates the immune response
    Lauren A Zenewicz
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104
    J Immunol 174:8011-6. 2005
    ..These data indicate that B. anthracis PI-PLC down-modulates DC function and T cell responses, possibly by cleaving GPI-anchored proteins important for TLR-mediated DC activation...

Research Grants46

  1. Steven A Lietman; Fiscal Year: 2015
    ..K02 funding for this project will help the candidate develop significantly as an independent scientist by protecting his time in the lab. ..
  2. Molecular Mechanisms in Bone Resorption
    Steven A Lietman; Fiscal Year: 2012
    ..New information about mechanisms of bone resorption may facilitate the development of novel strategies to decrease bone resorption and may lead to new treatments for osteoporosis. ..
  3. Activation of PI Specific Phospholipase C Enzymes
    MARY FEDARKO ROBERTS; Fiscal Year: 2013
    ..The studies of the bacterial enzymes may provide new treatments for slowing/inhibiting infections. ..
  4. ROLE OF PHOSPHOLIPASE C IN T CELL ACTIVATION
    ROBERT GOLDFIEN; Fiscal Year: 1991
    ....
  5. IGA FC RECEPTORS
    JULIA PHILLIPS QUAGLIATA; Fiscal Year: 1993
    ..5) To establish whether the receptor plays a physiological role in the function of the cells...
  6. Enhancing axon regeneration by multi-inhibitor blocking
    RONALD SCHNAAR; Fiscal Year: 2005
    ..The resulting data may provide insight on the relative contributions of the different ARI's in an in vivo model, and may support evaluation of new approaches to enhance axon regeneration after CNS injury. ..
  7. Membrane Rafts and Sertoli-Germ Cell Interactions
    SALLY NYQUIST; Fiscal Year: 2002
    ....
  8. PHOSPHOLIPASES AND THE PATHOGENESIS OF LISTERIA
    Howard Goldfine; Fiscal Year: 1993
    ..This research poses novel questions concerning the role of bacterial PLCs in a significant intracellular pathogen...
  9. REGULATION OF PHOSPHOLIPASE C
    T Harden; Fiscal Year: 2002
    ..Completion of the work described in this proposal should considerably extend knowledge of the identify, specificity, and mechanism of interaction of the component proteins of the receptor-regulated inositol lipid signalling pathway. ..
  10. MECHANISTIC STUDIES OF PHOSPHOLIPID PHOSPHODIESTERASES
    Stephen Martin; Fiscal Year: 1999
    ..E. Hough (Univ. of Tromso) and Prof. Robertus, whereas those with PI-PLC will be executed with Prof. Griffith and Dr. Dirk Heinz (Universitat Freiburg). ..
  11. Respiratory syncytial virus targets rafts for penetration and immunomodulation
    HOMERO GABRIEL SAN JUAN VERGARA; Fiscal Year: 2010
    ..8% of the new cases of lower tract respiratory illness in infants. Understanding the mechanistic process of the RSV infection will help in the development of the vaccines and therapies. ..
  12. CYCLIC AMP/ADENOSINE PATHWAY
    Edwin Jackson; Fiscal Year: 2002
    ..abstract_text> ..
  13. PI/PLC FUNCTION IN PREGNANT RAT MYOMETRIUM
    Mark Phillippe; Fiscal Year: 2002
    ..s. ..
  14. Novel phospholipases C in trypanosomatids
    Silvia Moreno; Fiscal Year: 2009
    ..abstract_text> ..
  15. MODULATION OF THE PI-PATHWAY IN PREGNANT MYOMETRIUM
    Mark Phillippe; Fiscal Year: 1999
    ..These proposed studies can be anticipated to clarify the effects of estradiol and progesterone on the PI -signaling pathway in pregnant myometrium; thereby further elucidating the hormonal regulation of the onset of parturition. ..
  16. REGULATION OF ION CHANNELS BY SPECIFIC G PROTEINS
    MALGORZATA WILK BLASZCZAK; Fiscal Year: 1999
    ..Thus this project is relevant for understanding and treating diseases of both the central nervous system and the peripheral tissues. ..
  17. LIPID SIGNALLING IN THE CELL NUCLEUS
    ALAN FIELDS; Fiscal Year: 2002
    ..The second and third specific aims therefore propose to expand and confirm these preliminary results of the roles of nuclear PI3K and PKB in these cellular events. ..
  18. PROBES AND MODULATORS OF THE PI-PLC CASCADE
    RAJINDRA ANEJA; Fiscal Year: 1992
    ..These opportunities, studies on the behavior towards selected mammalian PI-PLCs, and other enzymes pertinent to the signalling cascades, and their natural occurrence as mediators in cell physiology, will be investigated during Phase II...
  19. MOLECULAR BASIS FOR PROTEIN/PHOSPHOLIPID INTERACTION
    Jon Lomasney; Fiscal Year: 2003
    ..These studies should not only increase understanding of basic cardiovascular regulation, but also have the potential to promote the development of novel post-receptor therapeutics and new diagnostic tools. ..
  20. ROLE OF PHOSPHOINOSITIDES IN HUMAN PLATELET SECRETION
    SUSAN RITTENHOUSE; Fiscal Year: 1980
    ..In conjunction with this work, we plan to examine the phosphoinositide metabolism of platelets displaying defective secretion from patients with recognized functional defects. ..
  21. MOLECULAR BASIS FOR PROTEIN/PHOSPHOLIPID INTERACTION
    Jon Lomasney; Fiscal Year: 2000
    ..These studies should not only increase understanding of basic cardiovascular regulation, but also have the potential to promote the development of novel post-receptor therapeutics and new diagnostic tools. ..
  22. Validating microRNA Analysis in Human Postmortem Brain
    Yogesh Dwivedi; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  23. PI and Wnt Signaling in Postmortem Brain of Biopolar and Schizophrenia Subjects
    Ghanshyam N Pandey; Fiscal Year: 2011
    ..This may eventually lead to i better understanding of the pathophysiology of BP or SZ illnesses and may aid in the development of more appropriate therapeutic agents for the treatment of these disorders. ..
  24. PKC and Cellular Signaling in the Suicide Brain
    Ghanshyam Pandey; Fiscal Year: 2009
    ..This knowledge may aid in developing better therapeutic strategies for the treatment of suicidal behavior. ..
  25. POSTRECEPTOR DYSREGULATION IN DEPRESSION
    Yogesh Dwivedi; Fiscal Year: 2004
    ..abstract_text> ..
  26. Signal Transduction Mechanisms in Suicide Brain
    Yogesh Dwivedi; Fiscal Year: 2008
    ..abstract_text> ..
  27. Escape of Bacillus anthracis from the phagsome
    Howard Goldfine; Fiscal Year: 2004
    ..abstract_text> ..
  28. STRUCTURE/FUNCTION OF PI-SPECIFIC PHOSPHOLIPASE C
    O Griffith; Fiscal Year: 2001
    ..Finally, the new substrate analogs and inhibitors will be used in a comparative study of the PI-PLC virulence indicators of S. aureus and L. monocytogenes. ..
  29. LONG TERM HIPPOCAMPAL MEMORY
    Pramod Dash; Fiscal Year: 2001
    ..Understanding the molecular basis of memory storage will be of value in the future development of pharmacological agents to treat amnesia associated with neurological disorders and other mental health related problems. ..
  30. Coordination of signaling during phagocytosis
    Joel A Swanson; Fiscal Year: 2010
    ..Because these studies will measure signal amplitudes as a function of particle size, they should identify size thresholds for FcR signaling and determine the relative contribution of 3'Pls to those thresholds. ..
  31. CHARACTERIZATION OF A NOVEL G PROTEIN IN PLATELETS
    Lawrence Brass; Fiscal Year: 2005
    ..All four of these aims will combine biochemical and pharmacologic approaches with studies on genetically engineered mice lacking selected receptors and G proteins, allowing us to better understand platelet activation in vivo. ..
  32. URINARY BLADDER MUSCARINIC RECEPTOR SUBTYPES
    MICHAEL RUGGIERI; Fiscal Year: 2003
    ..3. To characterize the changes in M2 M3 receptor phosphorylation that may accompany receptor desensitization and receptor up and down regulation. ..
  33. Working memory deficits following brain trauma
    Pramod Dash; Fiscal Year: 2009
    ..An understanding of the mechanisms by which TBI alters dopamine signaling is critical for the development of mechanism-based intelligent pharmacological treatments for working memory deficits for brain trauma patients. ..
  34. Prefrontal cortex and memory storage
    Pramod K Dash; Fiscal Year: 2010
    ....
  35. Myogenic tone in the urethra and its modulation
    Mark Hollywood; Fiscal Year: 2009
    ....
  36. Molecular Mechanisms of Ectopic Bone Formation
    STEVEN LIETMAN; Fiscal Year: 2006
    ..abstract_text> ..
  37. Mechanisms of Anthrax Toxin Signaling in Macrophages
    Joel Swanson; Fiscal Year: 2003
    ..In doing so, they will guide the selection and design of effective, late-stage therapeutics. ..
  38. Blood Systems Biology
    Lawrence Brass; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  39. FASEB Conf. Proteases in Hemostasis and Vascular Biology
    Lawrence Brass; Fiscal Year: 2005
    ..Tissue factor, platelets and coagulation; 8. Regulators of hemostasis; 9. Protease receptors. The keynote lecture will be on gene therapy for disorders of hemostasis delivered by Dr. Katherine High. ..
  40. Manipulation of Phagocytosis in Macrophage
    Joel Swanson; Fiscal Year: 2008
    ..Consequent effects on the efficiency of Lm escape from vacuoles will be quantified. ..
  41. MECHANISMS OF MEMORY DEFICITS FOLLOWING BRAIN INJURY
    Pramod Dash; Fiscal Year: 2006
    ..Furthermore, this project will broaden our understanding of the pathogenesis of neurodegenerative diseases such as stroke and Alzheimer's disease. ..
  42. RPE-Mphi Binding: Ca++_&O2-_Dependent AMD Responses
    Victor Elner; Fiscal Year: 2008
    ..This new knowledge is likely to lead to advances in therapy, which may stem or prevent AMD. ..
  43. 2007 Phagocytes
    Joel Swanson; Fiscal Year: 2007
    ..abstract_text> ..
  44. Proteomic studies of normal and abnormal platelet function
    Lawrence Brass; Fiscal Year: 2007
    ..This includes novel methods that permit quantitation of individual molecules so that changes in levels of expression can be measured. [unreadable] [unreadable] [unreadable]..
  45. Role of Endocannabinoid Signaling in Alcoholism
    BALAPAL BASAVARAJAPPA; Fiscal Year: 2007
    ..The better understanding of these mechanisms will yield new drug therapies with potential in treatment of alcoholism. ..