Genomes and Genes
Gene Symbol: PLCB1
Description: phospholipase C beta 1
Alias: EIEE12, PI-PLC, PLC-154, PLC-I, PLC-beta-1, PLC154, PLCB1A, PLCB1B, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1, 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate, inositoltrisphosphohydrolase, monophosphatidylinositol phosphodiesterase, phosphoinositidase C, phospholipase C, beta 1 (phosphoinositide-specific), phospholipase C-I, triphosphoinositide phosphodiesterase
Publications252 found, 100 shown here
- Nuclear inositide signaling: an appraisal of phospholipase C beta 1 behavior in myelodysplastic and leukemia cellsLucio Cocco
Cellular Signalling Laboratory, Department of Anatomical Sciences, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
Adv Enzyme Regul 47:2-9. 2007
- Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathwayD Cefai
Laboratoire d Immunologie Cellulaire et Tissulaire, Group Hospitalier GH Pitié Salpétrière, Paris, France
J Clin Invest 86:2117-24. 1990....
- Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tatN J Haughey
Department of Pharmacology and Therapeutics, University of Manitoba Faculty of Medicine, Winnipeg, Canada
J Neurochem 73:1363-74. 1999....
- Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1)A Caricasole
Biology Department, GlaxoWellcome Medicines Research Centre, Verona, Italy
Biochim Biophys Acta 1517:63-72. 2000..Four mammalian isozymes are known (PLC beta 1-4), which differ in their function and expression patterns in vivo...
- Phosphatidylcholine-specific phospholipase C activation is required for CCR5-dependent, NF-kB-driven CCL2 secretion elicited in response to HIV-1 gp120 in human primary macrophagesLaura Fantuzzi
Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
Blood 111:3355-63. 2008....
- Protein kinase C phosphorylation of PLCβ1 regulates its cellular localizationOmozuanvbo Aisiku
Department of Physiology and Biophysics, Stony Brook University, Stony Brook, NY 11794 8661, USA
Arch Biochem Biophys 509:186-90. 2011..Our studies suggest that PKC phosphorylation regulates the level of PLCβ1 cytosolic and nuclear activity by regulating its cellular compartmentalization...
- Homozygous PLCB1 deletion associated with malignant migrating partial seizures in infancyAnnapurna Poduri
Department of Neurology, Children s Hospital Boston, Boston, Massachusetts 02115, USA
Epilepsia 53:e146-50. 2012..homozygous deletion of chromosome 20p13, disrupting the promoter region and first three coding exons of the gene PLCB1. Additional MMPEI cases were screened for similar deletions or mutations in PLCB1 but did not harbor mutations...
- PLCβ isoforms differ in their subcellular location and their CT-domain dependent interaction with GαqMerel J W Adjobo-Hermans
Swammerdam Institute for Life Sciences, Section of Molecular Cytology, van Leeuwenhoek Centre for Advanced Microscopy, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands
Cell Signal 25:255-63. 2013..These findings suggest that under physiological circumstances, PLCβ3 and Gαq interact in a kiss-and-run fashion, likely due to the GTPase-activating activity of PLCβ towards Gαq...
- Phospholipase C-beta 1 is a GTPase-activating protein for Gq/11, its physiologic regulatorG Berstein
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas 75235 9041
Cell 70:411-8. 1992..Such GAP activity by an effector coupled to a trimeric G protein can reconcile slow GTP hydrolysis by pure G proteins in vitro with fast physiologic deactivation of G protein-mediated signaling...
- Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell lineG Zauli
Institute of Human Anatomy, University of Ferrara, Italy
Eur J Immunol 25:2695-700. 1995..The relevance of these findings for a better understanding of the biological functions of extracellular Tat is discussed...
- Identification and chromosomal localisation by fluorescence in situ hybridisation of human gene of phosphoinositide-specific phospholipase C beta(1)D Peruzzi
Cellular Signalling Laboratory, Institute of Anatomy at the University of Bologna, Via Irnerio 48, I 40126, Bologna, Italy
Biochim Biophys Acta 1484:175-82. 2000....
- Determination of the contact energies between a regulator of G protein signaling and G protein subunits and phospholipase C beta 1L Dowal
Department of Physiology and Biophysics, State University of New York at Stony Brook, Stony Brook, New York 11794 8661, USA
Biochemistry 40:414-21. 2001..Comparison of the relative affinities between these interacting proteins will ultimately allow us to determine whether certain complexes can form and where signals will be directed...
- Interleukin 2 activates nuclear phospholipase Cbeta by mitogen-activated protein kinase-dependent phosphorylation in human natural killer cellsM Vitale
Institute of Human Anatomy, University of Parma, Ospedale Maggiore, 14 43100 Parma, Italy
FASEB J 15:1789-91. 2001
- Induction of the Galpha(q) signaling cascade by the human immunodeficiency virus envelope is required for virus entryBrooke Harmon
Division of Molecular Oncology, Washington University School of Medicine, St Louis, Missouri, USA
J Virol 82:9191-205. 2008..These results could provide a new focus for therapeutic intervention with drugs targeting host signaling mediators rather than viral molecules, a strategy which is less likely to result in resistance...
- Phosphatidic acid regulates signal output by G protein coupled receptors through direct interaction with phospholipase C-beta(1)Irene Litosch
Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, Florida 33101, USA
Cell Signal 21:1379-84. 2009..Galpha(q) and PA may co-ordinate to regulate signaling. Regulation by PA may constitute part of a mechanism that routes receptor signaling to specific PLC isoforms...
- Activation of host phospholipases C and D in macrophages after infection with Listeria monocytogenesH Goldfine
Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6076, USA
Infect Immun 68:5735-41. 2000..Pretreatment of J774 cells with the PLD inhibitor, 2, 3-diphosphoglycerate partially inhibited escape of the bacteria from the primary phagocytic vacuole...
- Activation of phosphatidylinositol-specific phospholipase C by HDL-associated lysosphingolipid. Involvement in mitogenesis but not in cholesterol effluxJ R Nofer
Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat, Munster, Germany
Biochemistry 39:15199-207. 2000..Apo A-I stimulates phosphatidylcholine breakdown and thereby facilitates cholesterol efflux, whereas LSF and SPC trigger PI-PLC activation and thereby stimulate cell proliferation...
- Detection of multiple virulence-associated genes in Listeria monocytogenes isolated from bovine mastitis casesD B Rawool
Division of Veterinary Public Health, Indian Veterinary Research Institute, Izatnagar 243 122, India
Int J Food Microbiol 113:201-7. 2007..monocytogenes and plcA, prfA and actA genes for L. ivanovii) hold a good promise as rapid and reliable in vitro alternatives to in vivo pathogenicity tests...
- Evaluation and interlaboratory validation of a selective agar for phosphatidylinositol-specific phospholipase C activity using a chromogenic substrate to detect Listeria monocytogenes from foodsKaren C Jinneman
Food and Drug Administration, Office of Regulatory Affairs, Pacific Regional Laboratory Northwest, 22201 23rd Drive S E, Bothell, Washington 98021, USA
J Food Prot 66:441-5. 2003..3, 99.2, and 90.2%, respectively. In statistical analyses of the different combinations of agars, the OXF-BCM and BCM-PAL combinations were found to be superior to the OXF-PAL combination for the detection of L. monocytogenes...
- Gangliosides and Nogo receptors independently mediate myelin-associated glycoprotein inhibition of neurite outgrowth in different nerve cellsNiraj R Mehta
Department of Pharmacology, The Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
J Biol Chem 282:27875-86. 2007..Our data indicate that MAG inhibits axon outgrowth via two independent receptors, gangliosides and NgRs...
- Genetic and biochemical characterization of a phosphatidylinositol-specific phospholipase C in Saccharomyces cerevisiaeJ S Flick
Department of Molecular and Cell Biology, University of California, Berkeley 94720
Mol Cell Biol 13:5861-76. 1993..The findings reported here suggest that hydrolysis of PIP2 in S. cerevisiae is required for a number of nutritional and stress-related responses...
- Crystal structure of phosphatidylinositol-specific phospholipase C from Bacillus cereus in complex with glucosaminyl(alpha 1-->6)-D-myo-inositol, an essential fragment of GPI anchorsD W Heinz
Institut fur Organische Chemie und Biochemie, Universitat Freiburg, Germany
Biochemistry 35:9496-504. 1996..cereus PI-PLC. This explains why B. cereus PI-PLC can cleave GPI anchors having variable glycan structures...
- The biological significance of phospholipase C beta 1 gene mutation in mouse sperm in the acrosome reaction, fertilization, and embryo developmentD Choi
Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, IVF Clinic, Samsung Medical Center, Seoul, Korea
J Assist Reprod Genet 18:305-10. 2001..We carried out this study to evaluate the biological significance of phospholipase C beta 1 gene mutation in mouse sperm in the acrosome reaction, fertilization, and embryo development...
- G beta gamma mediates the interplay between tubulin dimers and microtubules in the modulation of Gq signalingJuliana S Popova
Department of Physiology and Biophysics, College of Medicine, University of Illinois, Chicago, Illinois 60612 7342, USA
J Biol Chem 278:34299-308. 2003Agonist stimulation causes tubulin association with the plasma membrane and activation of PLC beta 1 through direct interaction with, and transactivation of, G alpha q...
- Characterization of G protein-coupled receptors expressed by ECV304 human endothelial cellsJ Howl
University of Wolverhampton, School of Health Sciences, UK
Endothelium 6:23-32. 1998..receptors, P2U-purinoceptors and lysophosphatidic acid receptors which are functionally coupled to phosphoinositidase C. G protein-coupled receptors which bind adenosine (A2 receptor), calcitonin, and adrenaline (beta-..
- Allosteric activation of the extracellular Ca2+-sensing receptor by L-amino acids enhances ERK1/2 phosphorylationHeather J Lee
School of Molecular and Microbial Biosciences, University of Sydney, Sydney, NSW 2006, Australia
Biochem J 404:141-9. 2007....
- Phosphatidic acid is the prominent product of endogenous neuronal nuclear lipid phosphorylation, an activity enhanced by sphingosine, linked to phospholipase C and associated with the nuclear envelopeR R Baker
Department of Biochemistry, Room 5202, Medical Sciences Bldg, University of Toronto, Toronto, ON M5S 1A8, Canada
Biochim Biophys Acta 1534:110-20. 2001..b>Phosphoinositidase C was present in the nuclei and inhibitors of this enzyme did decrease PA formation, indicating ..
- Phosphorothiolate analogues of phosphatidylinositols as assay substrates for phospholipase CYinghui Liu
Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago IL 60612, USA
Chembiochem 8:1430-9. 2007..In addition, the binding affinities of all four substrate types were found to be quite similar; this indicates that the energy of enzyme interaction with the 4-phosphate group is directed almost entirely to catalysis...
- Incorporation of ethanolamine into insulin-sensitive glycosylated phosphatidylinositol of chick embryo fibroblastsM Kajiyoshi
Department of Pathological Biochemistry, Medical Research Institute, Medical and Dental University, Kandasurugadai, Chiyoda ku, 2 3 10, Tokyo 101 0062, Japan
Biochim Biophys Acta 1488:255-67. 2000..The results indicate that peak I lipid contains primary ethanolamine as a glycan component and is insulin-sensitive free GPI...
- Conversion of raft associated prion protein to the protease-resistant state requires insertion of PrP-res (PrP(Sc)) into contiguous membranesGerald S Baron
Laboratory of Persistent Viral Diseases, NIAID, NIH, Rocky Mountain Laboratories, 903 South 4th Street, Hamilton, MT 59840, USA
EMBO J 21:1031-40. 2002....
- Activation of human neutrophils by soluble immune complexes: role of Fc gamma RII and Fc gamma RIIIb in stimulation of the respiratory burst and elevation of intracellular Ca2+S W Edwards
School of Biological Sciences, University of Liverpool, United Kingdom
Ann N Y Acad Sci 832:341-57. 1997....
- Chlorpromazine inhibits the glucocorticoid receptor-mediated gene transcription in a calcium-dependent mannerA Basta-Kaim
Department of Endocrinology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343 Krakow, Poland
Neuropharmacology 43:1035-43. 2002..The inhibitory effect of chlorpromazine on the corticosterone-induced gene transcription seems to depend on the inhibition of Ca(2+) influx and/or the inhibition of some calcium-dependent enzymes, e.g. phospholipase beta(1)...
- Regulation of phospholipase C-beta activity by phosphatidic acid: isoform dependence, role of protein kinase C, and G protein subunitsIrene Litosch
Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Florida 33101, USA
Biochemistry 42:1618-23. 2003..PA may be an important component of a receptor mediated signaling mechanism that determines PLC-beta(1) activation...
- Thromboxane-insensitive dog platelets have impaired activation of phospholipase C due to receptor-linked G protein dysfunctionG J Johnson
Department of Medicine, Veterans Administration Medical Center, Minneapolis, Minnesota 55417
J Clin Invest 92:2469-79. 1993..Thus, TXA2- dog platelets have impaired PI-PLC activation in response to TXA2/PGH2 receptor agonists secondary to G protein dysfunction, presumably involving a member of the Gq class...
- Application of capillary electrophoresis to determination of enzyme activity and other properties of phosphatidylinositol-specific phospholipase CM J Suh
Doping Control Center, Korea Institute of Science and Technology, Seoul, South Korea
J Chromatogr A 781:263-70. 1997....
- Fuel and hormone regulation of phospholipase C beta 1 and delta 1 overexpressed in RINm5F pancreatic beta cellsG G Kelley
Department of Medicine, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
Mol Cell Endocrinol 177:107-15. 2001..Previous studies have suggested that glucose may couple to PLC beta 1 and PLC delta 1...
- Ecto-5'-nucleotidase and intestinal ion secretion by enteropathogenic Escherichia coliJohn K Crane
Department of Medicine, Division of Infectious Diseases, University at Buffalo, Room 317 Biomedical Research Bldg, 3435 Main St, Buffalo, NY, 14214, USA
Purinergic Signal 3:233-46. 2007....
- Bradykinin- and thrombin-induced increases in endothelial permeability occur independently of phospholipase C but require protein kinase C activationJ L Aschner
Department of Pediatrics, Bowman Gray School of Medicine of Wake Forest University, Winston Salem, North Carolina 27157 1081, USA
J Cell Physiol 173:387-96. 1997....
- Functional demonstration of surface carbonic anhydrase IV activity on rat astrocytesNataliya Svichar
Department of Neurosurgery, New York University School of Medicine, New York, New York 10016, USA
Glia 53:241-7. 2006..Thus, our data collectively document the presence of CAIV on the surface of brain astrocytes, and suggest that this is the predominant CA isoform on these cells...
- Bile acid reflux contributes to development of esophageal adenocarcinoma via activation of phosphatidylinositol-specific phospholipase Cgamma2 and NADPH oxidase NOX5-SJie Hong
Department of Medicine, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
Cancer Res 70:1247-55. 2010....
- Phospholipase C beta 1 deficiency is associated with early-onset epileptic encephalopathyManju A Kurian
Department of Medical and Molecular Genetics, University of Birmingham School of Medicine, Institute of Biomedical Research, Birmingham, UK
Brain 133:2964-70. 2010..Although phospholipase C-β 1 deficiency has not previously been reported in humans, the Plcb1 homozygote knockout mouse displays early-onset severe tonic seizures and growth retardation, thus recapitulating ..
- Effects of scalaradial, a novel inhibitor of 14 kDa phospholipase A2, on human neutrophil functionM S Barnette
Department of Inflammation and Respiratory Pharmacology, SmithKline Beecham Laboratories, King of Prussia, PA 19406
Biochem Pharmacol 47:1661-7. 1994....
- Probing the roles of active site residues in phosphatidylinositol-specific phospholipase C from Bacillus cereus by site-directed mutagenesisC S Gassler
Institut fur Organische Chemie und Biochemie, Universitat Freiburg, D 79104 Freiburg, Germany
Biochemistry 36:12802-13. 1997....
- Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2D Park
Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
J Biol Chem 267:16048-55. 1992..see also accompanying article (Lee, C. H., Park, D., Wu, D., Rhee, S. G., and Simon, M. I. (1992) J. Biol. Chem. 267, 16044-16047)...
- Mechanisms of leukotriene D4-induced constriction in human small bronchiolesV A Snetkov
Department of Respiratory Medicine and Allergy, Guy s, King s and St Thomas School of Medicine, King s College London, Guy s Campus, London SE1 9RT
Br J Pharmacol 133:243-52. 2001..We conclude that LTD4 causes constriction of these small bronchioles primarily by activating Ca2+ entry via non-voltage gated channels, possibly by a PC-PLC mediated pathway...
- Antidepressants reduce phosphoinositide-specific phospholipase C (PI-PLC) activity and the mRNA and protein expression of selective PLC beta 1 isozyme in rat brainY Dwivedi
Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 W Taylor St, Chicago, IL 60612, USA
Neuropharmacology 43:1269-79. 2002..Our results thus suggest that modulation of PI-PLC may be common to all classes of antidepressants, which in turn, may be associated with their mechanisms of action...
- The role of phospholipase C and phosphatidylinositol 3-kinase in vascular smooth muscle cell migration and proliferationBo Liu
Department of Surgery, Division of Vascular Surgery, New York Presbyterian Hospital and Weill Medical College of Cornell University, 525 East 68th Street, Payson 707, New York, NY 1002, USA
J Surg Res 120:256-65. 2004..In this study, we investigate the role of PLC and PI3-K in platelet-derived growth factor (PDGF) and extracellular matrix protein (ECM) induced SMC proliferation and migration...
- Phospholipase C beta3 is a key component in the Gbetagamma/PKCeta/PKD-mediated regulation of trans-Golgi network to plasma membrane transportAlberto M Díaz Añel
Center for Molecular Genetics, University of California at San Diego, San Diego, CA, USA
Biochem J 406:157-65. 2007..In conclusion, we demonstrate that fission of transport carriers at the TGN is dependent on PI-PLCs, specifically PLCbeta3, which is necessary to activate PKCeta and PKD in that Golgi compartment, via DAG production...
- Expression of glycophosphatidylinositol-anchored and -non-anchored isoforms of vascular cell adhesion molecule 1 in murine stromal and endothelial cellsT Kinashi
Center for Blood Research, Harvard Medical School, Boston, Massachusetts 02115
J Leukoc Biol 57:168-73. 1995..The GPI-anchored isoform is functionally important, because on a cell on which it was expressed almost as well as the 100 kDa isoform, treatment with PI-PLC reduced VLA-4-dependent conjugate formation...
- Effects of pertussis toxin on extracellular signal-regulated kinase activation in hepatocytes by hormones and receptor-independent agents: evidence suggesting a stimulatory role of G(i) proteins at a level distal to receptor couplingO Melien
Department of Pharmacology, Faculty of Medicine, University of Oslo, Blindern, Oslo, Norway
J Cell Physiol 184:27-36. 2000....
- Activation of phospholipase D by metabotropic glutamate receptor agonists in rat cerebrocortical synaptosomesT Shinomura
Department of Pharmacology and Neuroscience, Ninewells Hospital Medical School, University of Dundee, Dundee, DD1 9SY
Br J Pharmacol 131:1011-8. 2000..These data suggest that, in rat cerebrocortical synaptosomes, the 1S,3R-ACPD-sensitive mGluR is coupled to PLD through a mechanism that is independent of both PKC and PI-PLC...
- Phospholipase C expression and activity in smooth muscle cells of renal arterioles and aorta of young, spontaneously hypertensive rats during cultureZhangping Peng
Department of Cell and Molecular Physiology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7545, USA
Am J Hypertens 20:520-6. 2007..We assessed the stability of variables over passages 3 to 11...
- The phosphoinositide-phospholipase C (PI-PLC) pathway in the mouse oocyteBrigitte Lefevre
INSERM U566 CEA DRR LGAG Univ Paris 7, Batiment 05, Route du Panorama, F 92260, Fontenay aux Roses, France
Crit Rev Eukaryot Gene Expr 17:259-69. 2007..Phospholipase C beta1 (PLC beta 1) is first exclusively localized to the nucleus and then migrates to the cytoplasm when the oocyte is fully grown...
- Correlation of vesicle binding and phospholipid dynamics with phospholipase C activity: insights into phosphatidylcholine activation and surface dilution inhibitionMingming Pu
Boston College, Chestnut Hill, Massachusetts 02467, USA
J Biol Chem 284:16099-107. 2009..Both methodologies provide a detailed view of protein-lipid interactions and can be readily adapted for other peripheral membrane proteins...
- Cyclic GMP regulates activation of phosphoinositidase C by bradykinin in sensory neuronsJ S Harvey
Sandoz Institute for Medical Research, London, U K
Biochem J 316:539-44. 1996..ganglion (DRG) neurons to bradykinin resulted in marked attenuation of bradykinin-induced activation of phosphoinositidase C (PIC)...
- The human muscarinic M1 acetylcholine receptor, when express in CHO cells, activates and downregulates both Gq alpha and G11 alpha equally and non-selectivelyI Mullaney
Department of Biochemistry, University of Glasgow, Scotland, UK
FEBS Lett 324:241-5. 1993CHO cells express both of the phosphoinositidase C-linked G-proteins Gq and G11. G11 alpha is some 2.5-fold more highly expressed than Gq alpha in membranes of these cells...
- Osmotic stress activates phosphatidylinositol-3,5-bisphosphate synthesisS K Dove
Centre for Clinical Research in Immunology and Signalling, University of Birmingham, UK
Nature 390:187-92. 1997..Two widespread eukaryotic phosphoinositide-based signal transduction mechanisms, phosphoinositidase C-catalysed phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) hydrolysis and 3-OH kinase-catalysed PtdIns(..
- Crystal structure of the phosphatidylinositol-specific phospholipase C from the human pathogen Listeria monocytogenesJ Moser
Institut fur Organische Chemie und Biochemie, Universitat Freiburg, Germany
J Mol Biol 273:269-82. 1997..The active site pocket is also well conserved with only two amino acid replacements directly implicated in inositol binding...
- Glycosylphosphatidylinositol-anchored proteins play an important role in the biogenesis of the Alzheimer's amyloid beta-proteinK Sambamurti
Mayo Clinic, Jacksonville, Florida 32224, USA
J Biol Chem 274:26810-4. 1999..The cell-surface GPI-anchored protein(s) involved in Abeta biogenesis may be excellent therapeutic target(s) in Alzheimer's disease...
- Alteration of phosphoinositide degradation by cytosolic and membrane-bound phospholipases after forebrain ischemia-reperfusion in gerbil: effects of amyloid beta peptideJ Strosznajder
Department of Cellular Signalling, Medical Research Centre, Polish Academy of Sciences, Warszawa
Neurochem Res 24:1277-84. 1999..Ischemia-reperfusion injury had no effect on Abeta-evoked alterations of synaptic plasma membrane-bound PI-PLC...
- Mechanism of radiation-induced diacylglycerol production in primary cultured rat hepatocytesT Nakajima
Division of Biology and Oncology, National Institute of Radiological Sciences, Chiba shi, Japan
J Radiat Res 40:135-44. 1999..These results suggest that radiation exerts PI-PLC activation through hydroxyl radical generation, followed by diacylglycerol production and PKC activation...
- Tri-dimensional prostate cell cultures in simulated microgravity and induced changes in lipid second messengers and signal transductionS Clejan
Department of Pathology and Laboratory Medicine, Tulane University Health Science Center, 1430 Tulane Ave, SL 79, New Orleans, LA 70112 2699, USA
J Cell Mol Med 5:60-73. 2001....
- Effect of glycosylphosphatidylinositol anchor-dependent and -independent prion protein association with model raft membranes on conversion to the protease-resistant isoformGerald S Baron
Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, NIAID, National Institutes of Health, Hamilton, Montana 59840, USA
J Biol Chem 278:14883-92. 2003..Thus, of the two forms of raft membrane association by PrP-sen, only the GPI anchor-directed form resists conversion induced by exogenous PrP-res...
- New aspects of formation of 1,2-cyclic phosphates by phospholipase C-delta1Yinghui Liu
Department of Medicinal Chemistry and Pharmacognosy MC 781, University of Illinois at Chicago, Chicago, IL 60612, USA
Bioorg Med Chem 11:2471-5. 2003..The potential significance of the cyclic products in the signaling pathways is also discussed...
- 1alpha,25(OH)2D3 causes a rapid increase in phosphatidylinositol-specific PLC-beta activity via phospholipase A2-dependent production of lysophospholipidZ Schwartz
Department of Biomedical Engineering, Georgia Institute of Technology, 315 Ferst Drive, Atlanta, GA 30332, USA
Steroids 68:423-37. 2003..Antibodies to PLC-beta1 and PLC-beta3 blocked the 1alpha,25(OH)(2)D(3) effect; antibodies to PLC-delta and PLC-gamma did not. Thus, 1alpha,25(OH)(2)D(3) regulates PLC-beta through PLA(2)-dependent production of lysophospholipid...
- Water-miscible organic cosolvents enhance phosphatidylinositol-specific phospholipase C phosphotransferase as well as phosphodiesterase activityHania Wehbi
Department of Chemistry, E F Merkert Chemistry Center, Boston College, 2609 Beacon Street, Chestnut Hill, MA 02167, USA
Biochim Biophys Acta 1613:15-27. 2003....
- Involvement of nuclear phosphatidylinositol-dependent phospholipases C in cell cycle progression during rat liver regenerationElisabetta Albi
Department of Biochemical Sciences and Molecular Biotechnology, Physiopathology, Policlinico Monteluce, Perugia, Italy
J Cell Physiol 197:181-8. 2003..The increased activity of PI-PLC beta(1) constitutively present within the hepatocyte nucleus, should trigger DNA replication, whereas PI-PLC gamma(1) should be involved in G2/M phase transition through lamin phosphorylation...
- The Vr-PLC3 gene encodes a putative plasma membrane-localized phosphoinositide-specific phospholipase C whose expression is induced by abiotic stress in mung bean (Vigna radiata L.)Yun Ju Kim
Department of Biology, College of Science, Yonsei University, 120 749, Seoul, South Korea
FEBS Lett 556:127-36. 2004..The C2 domain was essential for Vr-PLC3 to be targeted to the plasma membrane. The possible biological functions of stress-responsive Vr-PLC3 in mung bean plants are discussed...
- Isolation of cDNAs encoding typical and novel types of phosphoinositide-specific phospholipase C from the moss Physcomitrella patensKoji Mikami
National Institute for Basic Biology, 38 Nishigonaka, Myodaiji, Okazaki 444 8585, Japan
J Exp Bot 55:1437-9. 2004..Furthermore, at millimolar Ca2+, phosphatidylinositol was hydrolysed by PpPLC2, but not by PpPLC1. Thus, PpPLC1 and PpPLC2 are typical and novel types of plant PI-PLC, respectively...
- Epidermal growth factor modulates prostate cancer cell invasiveness regulating urokinase-type plasminogen activator activity. EGF-receptor inhibition may prevent tumor cell disseminationClaudio Festuccia
Department of Experimental Medicine, L Aquila, Italy
Thromb Haemost 93:964-75. 2005....
- Targeting of protein kinase C-epsilon during Fcgamma receptor-dependent phagocytosis requires the epsilonC1B domain and phospholipase C-gamma1Keylon L Cheeseman
Center for Cell Biology and Cancer Research, Albany Medical College, Albany, NY 12208, USA
Mol Biol Cell 17:799-813. 2006..Together, these results support a model in which PI-PLC-gamma1 provides DAG that binds to epsilonC1B, facilitating PKC-epsilon localization to phagosomes for efficient IgG-mediated phagocytosis...
- Phosphoinositide-specific phospholipase C (PI-PLC) beta1 and nuclear lipid-dependent signalingLucio Cocco
Cellular Signalling Laboratory, Department of Human Anatomical Sciences, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
Biochim Biophys Acta 1761:509-21. 2006..This review aims at highlighting the most significant and up-dated findings about phosphoinositide-specific phospholipase C beta(1) in the nucleus...
- The complement regulatory proteins CD55 (decay accelerating factor) and CD59 are expressed on the inner acrosomal membrane of human spermatozoa as well as CD46 (membrane cofactor protein)J A Cummerson
Division of Immunology, School of Infection and Host Defence, University of Liverpool, Liverpool, UK
Immunology 118:333-42. 2006..Antibody-induced membrane rafting and release of CD55 & CD59 in vitro may have influenced previous results. Significant coexpression of CD55 & CD46 on the IAM suggests some functional cooperation at this site...
- Molecular defects in the ABCA1 pathway affect platelet functionGerd Schmitz
Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Germany
Pathophysiol Haemost Thromb 35:166-74. 2006..It is concluded that the presence of ABCA1 and ABCG1 in the AP-3 pathway will have major impact for membrane phospholipid processing and HDL metabolism and their relation to disorders of lysosome-related organelles...
- Modulation of ERK 1/2 and p38 MAPK signaling pathways by ATP in osteoblasts: involvement of mechanical stress-activated calcium influx, PKC and Src activationS Katz
Departamento de Biologia, Bioquimica y Farmacia, Universidad Nacional del Sur, San Juan 670, B8000ICN Bahia Blanca, Argentina
Int J Biochem Cell Biol 38:2082-91. 2006..This effect also involves upstream mediators such as PI-PLC, PKC and Src family kinases...
- Structural determinants for phosphatidic acid regulation of phospholipase C-beta1Elliott M Ross
Department of Molecular and Cellular Pharmacology, University of Miami, Miller School of Medicine, Miami, Florida 33101, USA
J Biol Chem 281:33087-94. 2006..PA regulation of PLC-beta(1) requires unique residues that are not required for Galpha(q) stimulation or GTPase-activating protein activity...
- Expression of phosphoinositide-specific phospholipase C isoenzymes in cultured astrocytesVincenza Rita Lo Vasco
Department of Fisiologia e Farmacologia V Erspamer, Respiratorie e Morfologiche, University of Rome La Sapienza, Rome, Italy
J Cell Biochem 100:952-9. 2007..In particular while some isoenzymes (namely isoforms beta3 and beta4) resulted mainly nuclear, others (isoforms delta4 and epsilon) were preferentially localized at cytoplasmic and plasma membrane level...
- Nuclear phospholipase C beta1 and cellular differentiationIrene Faenza
Cellular Signaling Laboratory, Department of Anatomical Sciences, University of Bologna, 40126 Bologna, Italy
Front Biosci 13:2452-63. 2008..In this report we will focus on the signal transduction-related metabolism of nuclear PI and review the most convincing evidence that the PI cycle is involved in differentiation programs in several cell systems...
- The alpha2delta subunits of voltage-gated calcium channels form GPI-anchored proteins, a posttranslational modification essential for functionAnthony Davies
Department of Neuroscience, Physiology and Pharmacology, University College, London WC1E 6BT, United Kingdom
Proc Natl Acad Sci U S A 107:1654-9. 2010..In conclusion, this study redefines our understanding of alpha(2)delta subunits, both in terms of their role in calcium-channel function and other roles in synaptogenesis...
- Developmental expression of a Trypanosoma cruzi phosphoinositide-specific phospholipase C in amastigotes and stimulation of host phosphoinositide hydrolysisVicente de Paulo Martins
Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602 2607, USA
Infect Immun 78:4206-12. 2010..The presence of TcPI-PLC on the outer surface of the plasma membrane of the parasite and the capacity to be secreted and to alter host phospholipids are novel mechanisms of the host-parasite interaction...
- SH3BP2 mutations potentiate osteoclastogenesis via PLCγSteven A Lietman
Department of Orthopaedic Surgery, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio 44195, USA
J Orthop Res 28:1425-30. 2010..The consequent activation of calcineurin and NFAT proteins induces the excessive osteoclastic phenotype of cherubism...
- Role of phosphoinositide-specific phospholipase C η2 in isolated and syndromic mental retardationVincenza Rita Lo Vasco
Department of Organi di Senso, University of Rome Sapienza, Italy
Eur Neurol 65:264-9. 2011..For its role in the nervous system, PI-PLC η2 might be a putative candidate gene for the neurodevelopmental delay observed in patients bearing 1p36.3 deletions...
- Vasopressin, ATP and catecholamines differentially control potassium secretion in inner ear cell lineJérôme Nevoux
UMR S 867, INSERM, UFR de Médecine Paris Diderot, Paris, France
FEBS Lett 585:2703-8. 2011..the presence of vasopressin, catecholamine and purinergic signaling pathways, coupled to adenylate cyclase, phosphoinositidase C and Ca(2+) activation...
- Glycosyl-phosphatidylinositol (GPI)-anchored membrane association of the porcine reproductive and respiratory syndrome virus GP4 glycoprotein and its co-localization with CD163 in lipid raftsYijun Du
Department of Pathobiology, University of Illinois at Urbana Champaign, Urbana, IL 61802, USA
Virology 424:18-32. 2012..Since CD163 has been reported as a cellular receptor for PRRSV and GP4 has been shown to interact with this receptor, our data implicates an important role of lipid rafts during entry of the virus...
- Medicago truncatula DNF2 is a PI-PLC-XD-containing protein required for bacteroid persistence and prevention of nodule early senescence and defense-like reactionsMarie Bourcy
Institut des Sciences du Vegetal, CNRS, Gif sur Yvette, France
New Phytol 197:1250-61. 2013..Furthermore, mutant nodules senesce rapidly and exhibit defense-like reactions. This atypical phenotype amongst Fix(-) mutants unravels dnf2 as a new actor of bacteroid persistence inside symbiotic plant cells...
- Expression changes and bioinformatic analysis of Wallerian degeneration after sciatic nerve injury in ratDengbing Yao
Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, 226019, China
Neurosci Bull 29:321-32. 2013..Some key factors were NGF, MAG, CNTF, CTNNA2, p53, JAK2, PLCB1, STAT3, BDNF, PRKC, collagen II, FGF, THBS4, TNC and c-Src, which were further validated by real-time quantitative ..
- Lack of pathogenic mutations in six patients with MMPSIMaria Rosaria De Filippo
Laboratory of Molecular Medicine and Genomics, Department of Medicine and Surgery, University of Salerno, Baronissi, Italy Fondazione IRCCS SDN, 80143 Napoli, Italy
Epilepsy Res 108:340-4. 2014Sequencing of the KCNT1, PLCB1, SCN1A and TBC1D24 loci was performed in six children with typical features of malignant migrating partial seizures of infancy (MMPSI), to verify the presence of potential disease-causing mutations, ..
- PLC-beta 1 regulates the expression of miR-210 during mithramycin-mediated erythroid differentiation in K562 cellsAlberto Bavelloni
SC Laboratory of Musculoskeletal Cell Biology, Rizzoli Orthopedic Institute, Bologna, Italy Laboratory RAMSES, Rizzoli Orthopedic Institute, Bologna, Italy
Oncotarget 5:4222-31. 2014....
- PLCβ1a and PLCβ1b selective regulation and cyclin D3 modulation reduced by kinamycin F during k562 cell differentiationAlberto Bavelloni
SC Laboratory of Musculoskeletal Cell Biology, Rizzoli Orthopedic Institute, Bologna, Italy Laboratory RAMSES, Rizzoli Orthopedic Institute, Bologna, Italy
J Cell Physiol 230:587-94. 2015..Our data indicate that the amplification of PLCβ1a expression, following treatment with kinamycin F, confers a real advantage to K562 cells viability and protects cells themselves from apoptosis...
- Orexin-A differentially modulates AMPA-preferring responses of ganglion cells and amacrine cells in rat retinaChao Zheng
Institute of Neurobiology, Institutes of Brain Science, State Key Laboratory of Medical Neurobiology and Collaborative Innovation Center for Brain Science, Fudan University, 138 Yixueyuan Road, Shanghai 200032, China Cell Electrophysiology Laboratory, Wannan Medical College, 22 West Wenchang Road, Wuhu, Anhui 241002, China
Neuropharmacology 93:80-93. 2015..These two actions of orexin-A, while working in concert, provide a characteristic way for modulating information processing in the inner retina. ..
- Participation of PLA2 and PLC in DhL-induced activation of Rhinella arenarum oocytesJ Zapata-Martínez
Departamento de Biología del Desarrollo INSIBIO, Chacabuco 461, 4000 San Miguel de Tucuman, Argentina
Zygote 24:495-501. 2016..Results would indicate that DhL induces activation of in vitro matured oocytes of Rhinella arenarum by activation of IP-PLC, which in turn may induce IP3 formation which produces Ca2+ release. ..
- PLCB1 epileptic encephalopathies; Review and expansion of the phenotypic spectrumAn Sofie Schoonjans
Department of Neurology Pediatric Neurology, University and University Hospital Antwerp, Antwerp, Belgium Electronic address
Eur J Paediatr Neurol 20:474-9. 2016Biallelic loss-of-function mutations of phospholipase C-β1 (PLCB1) have been described in three children with an early onset epileptic encephalopathy (EE)...
- Selective Activation of Nuclear PI-PLCbeta1 During Normal and Therapy-Related DifferentiationSara Mongiorgi
Cellular Signalling Laboratory, Department of Biomedical and Neuromotor Sciences, University of Bologna, Via Irnerio 48, 40126, Bologna, Italy
Curr Pharm Des 22:2345-8. 2016....
- Signaling mechanism for modulation by ATP of glycine receptors on rat retinal ganglion cellsPing Ping Zhang
Institutes of Brain Science, State Key Laboratory of Medical Neurobiology and Collaborative Innovation Center for Brain Science, Fudan University, 138 Yixueyuan Road, Shanghai 200032, China
Sci Rep 6:28938. 2016..These results suggest that ATP may modify the ON-to-OFF crossover inhibition, thus changing action potential patterns of OFF-GCs. ..
- Purification and cDNA cloning of bovine liver 5'-nucleotidase, a GPI-anchored protein, and its expression in COS cellsK Suzuki
Department of Microbial Chemistry, Faculty of Pharmaceutical Sciences, Nagoya City University
J Biochem 113:607-13. 1993..PI-PLC released 45% of the transiently expressed 5'-nucleotidase activity, indicating that the cDNA isolated here encodes this enzyme expressed as a GPI-anchored protein...
- Purification of a novel phospholipase C isozyme from bovine cerebellumD S Min
Department of Life Science, Pohang Institute of Science and Technology, Hyoja Dong, Korea
J Biol Chem 268:12207-12. 1993..Thus, we have designated this enzyme PLC-beta 4...
- Molecular characterization of a glycosylphosphatidylinositol-linked ADP-ribosyltransferase from lymphocytesI J Okazaki
Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1434, USA
Blood 88:915-21. 1996..Thus, we have cloned a novel gene that has properties identical to the transferase detected in CTL, and may be involved in the NAD-dependent regulation of proliferation and cytotoxicity...
- Phospholipases involved in lysophosphatidylinositol metabolism in rat brainT Kobayashi
Department of Biological Chemistry, Faculty of Pharmaceutical Sciences, Nagoya City University, Japan
J Lipid Mediat Cell Signal 14:33-7. 1996..These findings suggest possible pathways for PI metabolism through lysoPI to yield monoacylglycerol (mainly 2-arachidonoyl glycerol) and inositolphosphates in the brain, which are different from the well-characterized PI-PLC pathway...
- AtPLC2, a gene encoding phosphoinositide-specific phospholipase C, is constitutively expressed in vegetative and floral tissues in Arabidopsis thalianaT Hirayama
Laboratory of Plant Molecular Biology, The Institute of Physical and Chemical Research RIKEN, Tsukuba, Ibaraki, Japan
Plant Mol Biol 34:175-80. 1997..The AtPLC2 mRNA was detected in vegetative and floral tissues. We determined the positions of these two PI-PLCs genes on Arabidopsis chromosomes by RFLP mapping using P1 genomic clones...
- Efficacy of fluvoxamine in preventing relapse in alcohol dependence: a one-year, double-blind, placebo-controlled multicentre study with analysis by typologyJonathan Chick
Department of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh EH10 5HF, Scotland, UK
Drug Alcohol Depend 74:61-70. 2004..Tridimensional Personality Questionnaire, Types I and II had similar rates of survival without relapse on placebo (PLC I: 19.3%, n = 135; PLC II: 18.2%, n = 110), but on fluvoxamine Type II did worse than Type I (FLU I: 13...
- Phosphatidylinositol-specific phospholipase C of Bacillus anthracis down-modulates the immune responseLauren A Zenewicz
Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104
J Immunol 174:8011-6. 2005..These data indicate that B. anthracis PI-PLC down-modulates DC function and T cell responses, possibly by cleaving GPI-anchored proteins important for TLR-mediated DC activation...
- Steven A Lietman; Fiscal Year: 2015..K02 funding for this project will help the candidate develop significantly as an independent scientist by protecting his time in the lab. ..
- Molecular Mechanisms in Bone ResorptionSteven A Lietman; Fiscal Year: 2012..New information about mechanisms of bone resorption may facilitate the development of novel strategies to decrease bone resorption and may lead to new treatments for osteoporosis. ..
- Activation of PI Specific Phospholipase C EnzymesMARY FEDARKO ROBERTS; Fiscal Year: 2013..The studies of the bacterial enzymes may provide new treatments for slowing/inhibiting infections. ..
- ROLE OF PHOSPHOLIPASE C IN T CELL ACTIVATIONROBERT GOLDFIEN; Fiscal Year: 1991....
- IGA FC RECEPTORSJULIA PHILLIPS QUAGLIATA; Fiscal Year: 1993..5) To establish whether the receptor plays a physiological role in the function of the cells...
- Enhancing axon regeneration by multi-inhibitor blockingRONALD SCHNAAR; Fiscal Year: 2005..The resulting data may provide insight on the relative contributions of the different ARI's in an in vivo model, and may support evaluation of new approaches to enhance axon regeneration after CNS injury. ..
- Membrane Rafts and Sertoli-Germ Cell InteractionsSALLY NYQUIST; Fiscal Year: 2002....
- PHOSPHOLIPASES AND THE PATHOGENESIS OF LISTERIAHoward Goldfine; Fiscal Year: 1993..This research poses novel questions concerning the role of bacterial PLCs in a significant intracellular pathogen...
- REGULATION OF PHOSPHOLIPASE CT Harden; Fiscal Year: 2002..Completion of the work described in this proposal should considerably extend knowledge of the identify, specificity, and mechanism of interaction of the component proteins of the receptor-regulated inositol lipid signalling pathway. ..
- MECHANISTIC STUDIES OF PHOSPHOLIPID PHOSPHODIESTERASESStephen Martin; Fiscal Year: 1999..E. Hough (Univ. of Tromso) and Prof. Robertus, whereas those with PI-PLC will be executed with Prof. Griffith and Dr. Dirk Heinz (Universitat Freiburg). ..
- Respiratory syncytial virus targets rafts for penetration and immunomodulationHOMERO GABRIEL SAN JUAN VERGARA; Fiscal Year: 2010..8% of the new cases of lower tract respiratory illness in infants. Understanding the mechanistic process of the RSV infection will help in the development of the vaccines and therapies. ..
- CYCLIC AMP/ADENOSINE PATHWAYEdwin Jackson; Fiscal Year: 2002..abstract_text> ..
- PI/PLC FUNCTION IN PREGNANT RAT MYOMETRIUMMark Phillippe; Fiscal Year: 2002..s. ..
- Novel phospholipases C in trypanosomatidsSilvia Moreno; Fiscal Year: 2009..abstract_text> ..
- MODULATION OF THE PI-PATHWAY IN PREGNANT MYOMETRIUMMark Phillippe; Fiscal Year: 1999..These proposed studies can be anticipated to clarify the effects of estradiol and progesterone on the PI -signaling pathway in pregnant myometrium; thereby further elucidating the hormonal regulation of the onset of parturition. ..
- REGULATION OF ION CHANNELS BY SPECIFIC G PROTEINSMALGORZATA WILK BLASZCZAK; Fiscal Year: 1999..Thus this project is relevant for understanding and treating diseases of both the central nervous system and the peripheral tissues. ..
- LIPID SIGNALLING IN THE CELL NUCLEUSALAN FIELDS; Fiscal Year: 2002..The second and third specific aims therefore propose to expand and confirm these preliminary results of the roles of nuclear PI3K and PKB in these cellular events. ..
- PROBES AND MODULATORS OF THE PI-PLC CASCADERAJINDRA ANEJA; Fiscal Year: 1992..These opportunities, studies on the behavior towards selected mammalian PI-PLCs, and other enzymes pertinent to the signalling cascades, and their natural occurrence as mediators in cell physiology, will be investigated during Phase II...
- MOLECULAR BASIS FOR PROTEIN/PHOSPHOLIPID INTERACTIONJon Lomasney; Fiscal Year: 2003..These studies should not only increase understanding of basic cardiovascular regulation, but also have the potential to promote the development of novel post-receptor therapeutics and new diagnostic tools. ..
- ROLE OF PHOSPHOINOSITIDES IN HUMAN PLATELET SECRETIONSUSAN RITTENHOUSE; Fiscal Year: 1980..In conjunction with this work, we plan to examine the phosphoinositide metabolism of platelets displaying defective secretion from patients with recognized functional defects. ..
- MOLECULAR BASIS FOR PROTEIN/PHOSPHOLIPID INTERACTIONJon Lomasney; Fiscal Year: 2000..These studies should not only increase understanding of basic cardiovascular regulation, but also have the potential to promote the development of novel post-receptor therapeutics and new diagnostic tools. ..
- Validating microRNA Analysis in Human Postmortem BrainYogesh Dwivedi; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- PI and Wnt Signaling in Postmortem Brain of Biopolar and Schizophrenia SubjectsGhanshyam N Pandey; Fiscal Year: 2011..This may eventually lead to i better understanding of the pathophysiology of BP or SZ illnesses and may aid in the development of more appropriate therapeutic agents for the treatment of these disorders. ..
- PKC and Cellular Signaling in the Suicide BrainGhanshyam Pandey; Fiscal Year: 2009..This knowledge may aid in developing better therapeutic strategies for the treatment of suicidal behavior. ..
- POSTRECEPTOR DYSREGULATION IN DEPRESSIONYogesh Dwivedi; Fiscal Year: 2004..abstract_text> ..
- Signal Transduction Mechanisms in Suicide BrainYogesh Dwivedi; Fiscal Year: 2008..abstract_text> ..
- Escape of Bacillus anthracis from the phagsomeHoward Goldfine; Fiscal Year: 2004..abstract_text> ..
- STRUCTURE/FUNCTION OF PI-SPECIFIC PHOSPHOLIPASE CO Griffith; Fiscal Year: 2001..Finally, the new substrate analogs and inhibitors will be used in a comparative study of the PI-PLC virulence indicators of S. aureus and L. monocytogenes. ..
- LONG TERM HIPPOCAMPAL MEMORYPramod Dash; Fiscal Year: 2001..Understanding the molecular basis of memory storage will be of value in the future development of pharmacological agents to treat amnesia associated with neurological disorders and other mental health related problems. ..
- Coordination of signaling during phagocytosisJoel A Swanson; Fiscal Year: 2010..Because these studies will measure signal amplitudes as a function of particle size, they should identify size thresholds for FcR signaling and determine the relative contribution of 3'Pls to those thresholds. ..
- CHARACTERIZATION OF A NOVEL G PROTEIN IN PLATELETSLawrence Brass; Fiscal Year: 2005..All four of these aims will combine biochemical and pharmacologic approaches with studies on genetically engineered mice lacking selected receptors and G proteins, allowing us to better understand platelet activation in vivo. ..
- URINARY BLADDER MUSCARINIC RECEPTOR SUBTYPESMICHAEL RUGGIERI; Fiscal Year: 2003..3. To characterize the changes in M2 M3 receptor phosphorylation that may accompany receptor desensitization and receptor up and down regulation. ..
- Working memory deficits following brain traumaPramod Dash; Fiscal Year: 2009..An understanding of the mechanisms by which TBI alters dopamine signaling is critical for the development of mechanism-based intelligent pharmacological treatments for working memory deficits for brain trauma patients. ..
- Prefrontal cortex and memory storagePramod K Dash; Fiscal Year: 2010....
- Myogenic tone in the urethra and its modulationMark Hollywood; Fiscal Year: 2009....
- Molecular Mechanisms of Ectopic Bone FormationSTEVEN LIETMAN; Fiscal Year: 2006..abstract_text> ..
- Mechanisms of Anthrax Toxin Signaling in MacrophagesJoel Swanson; Fiscal Year: 2003..In doing so, they will guide the selection and design of effective, late-stage therapeutics. ..
- Blood Systems BiologyLawrence Brass; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- FASEB Conf. Proteases in Hemostasis and Vascular BiologyLawrence Brass; Fiscal Year: 2005..Tissue factor, platelets and coagulation; 8. Regulators of hemostasis; 9. Protease receptors. The keynote lecture will be on gene therapy for disorders of hemostasis delivered by Dr. Katherine High. ..
- Manipulation of Phagocytosis in MacrophageJoel Swanson; Fiscal Year: 2008..Consequent effects on the efficiency of Lm escape from vacuoles will be quantified. ..
- MECHANISMS OF MEMORY DEFICITS FOLLOWING BRAIN INJURYPramod Dash; Fiscal Year: 2006..Furthermore, this project will broaden our understanding of the pathogenesis of neurodegenerative diseases such as stroke and Alzheimer's disease. ..
- RPE-Mphi Binding: Ca++_&O2-_Dependent AMD ResponsesVictor Elner; Fiscal Year: 2008..This new knowledge is likely to lead to advances in therapy, which may stem or prevent AMD. ..
- 2007 PhagocytesJoel Swanson; Fiscal Year: 2007..abstract_text> ..
- Proteomic studies of normal and abnormal platelet functionLawrence Brass; Fiscal Year: 2007..This includes novel methods that permit quantitation of individual molecules so that changes in levels of expression can be measured. [unreadable] [unreadable] [unreadable]..
- Role of Endocannabinoid Signaling in AlcoholismBALAPAL BASAVARAJAPPA; Fiscal Year: 2007..The better understanding of these mechanisms will yield new drug therapies with potential in treatment of alcoholism. ..