PLC-gamma1

Summary

Gene Symbol: PLC-gamma1
Description: phospholipase C gamma 1
Alias: NCKAP3, PLC-II, PLC1, PLC148, PLCgamma1, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate, PLC-148, PLC-gamma-1, inositoltrisphosphohydrolase, monophosphatidylinositol phosphodiesterase, phosphatidylinositol phospholipase C, phosphoinositidase C, phosphoinositide phospholipase C, phosphoinositide phospholipase C-gamma-1, phospholipase C, gamma 1 (formerly subtype 148), phospholipase C-148, phospholipase C-II, triphosphoinositide phosphodiesterase
Species: human

Top Publications

  1. pmc Characterization and cDNA cloning of phospholipase C-gamma, a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase
    W H Burgess
    American Red Cross, Rockville, Maryland 20855
    Mol Cell Biol 10:4770-7. 1990
  2. pmc Recruitment and activation of phospholipase Cgamma1 by vascular endothelial growth factor receptor-2 are required for tubulogenesis and differentiation of endothelial cells
    Rosana D Meyer
    Departments of Ophthalmology and Biochemistry, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    J Biol Chem 278:16347-55. 2003
  3. pmc Calcium-induced human keratinocyte differentiation requires src- and fyn-mediated phosphatidylinositol 3-kinase-dependent activation of phospholipase C-gamma1
    Zhongjian Xie
    Endocrine Unit, Veterans Affairs Medical Center, Northern California Institute for Research and Education and University of California San Francisco, San Francisco, CA 94121, USA
    Mol Biol Cell 16:3236-46. 2005
  4. doi Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinases
    C Hugh Reynolds
    The MRC Centre for Neurodegeneration Research, King s College London, Institute of Psychiatry, London, UK
    J Biol Chem 283:18177-86. 2008
  5. doi Phospholipid scramblase 1 modulates a selected set of IgE receptor-mediated mast cell responses through LAT-dependent pathway
    Omid Amir-Moazami
    INSERM U699, and Faculté de Médecine Xavier Bichat, Universite Paris 7, 16 rue Henri Huchard, Paris, France
    J Biol Chem 283:25514-23. 2008
  6. ncbi CAIR-1/BAG-3 forms an EGF-regulated ternary complex with phospholipase C-gamma and Hsp70/Hsc70
    H Doong
    Molecular Signaling Section, Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland, MD 20892, USA
    Oncogene 19:4385-95. 2000
  7. ncbi The phosphorylated 1169-tyrosine containing region of flt-1 kinase (VEGFR-1) is a major binding site for PLCgamma
    A Sawano
    Institute of Medical Science, University of Tokyo, Minato ku, Tokyo, 108, Japan
    Biochem Biophys Res Commun 238:487-91. 1997
  8. ncbi Discoidin domain receptor 1 (DDR1) signaling in PC12 cells: activation of juxtamembrane domains in PDGFR/DDR/TrkA chimeric receptors
    E D Foehr
    Departments of Physiology and Biophysics, College of Medicine, University of California, Irvine, California 92697 4560, USA
    FASEB J 14:973-81. 2000
  9. pmc A phospholipase Cγ1-activated pathway regulates transcription in human vascular smooth muscle cells
    Irene Hunter
    School of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Cardiovasc Res 90:557-64. 2011
  10. doi Downregulation of erythropoietin receptor by overexpression of phospholipase C-gamma 1 is critical for decrease on focal adhesion in transformed cells
    Jin Ku Kang
    Department of Life Science, College of Natural Science, Daejin University, Pochen, Gyeonggido, South Korea
    Cell Oncol (Dordr) 34:11-21. 2011

Detail Information

Publications248 found, 100 shown here

  1. pmc Characterization and cDNA cloning of phospholipase C-gamma, a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase
    W H Burgess
    American Red Cross, Rockville, Maryland 20855
    Mol Cell Biol 10:4770-7. 1990
    ..Thus, HBGF-1 joins epidermal growth factor and platelet-derived growth factor, whose receptor activation leads to tyrosine phosphorylation and probable activation of phospholipase C-gamma...
  2. pmc Recruitment and activation of phospholipase Cgamma1 by vascular endothelial growth factor receptor-2 are required for tubulogenesis and differentiation of endothelial cells
    Rosana D Meyer
    Departments of Ophthalmology and Biochemistry, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    J Biol Chem 278:16347-55. 2003
    ..Further analysis showed that tyrosine 1006 is responsible for phospholipase Cgamma1 (PLCgamma1) activation and intracellular calcium release in endothelial cells...
  3. pmc Calcium-induced human keratinocyte differentiation requires src- and fyn-mediated phosphatidylinositol 3-kinase-dependent activation of phospholipase C-gamma1
    Zhongjian Xie
    Endocrine Unit, Veterans Affairs Medical Center, Northern California Institute for Research and Education and University of California San Francisco, San Francisco, CA 94121, USA
    Mol Biol Cell 16:3236-46. 2005
    ..These data indicate that calcium activates PLC-gamma1 via increased PIP3 formation mediated by c-src- and fyn-activated PI3K. This activation is required for calcium-induced human keratinocyte differentiation...
  4. doi Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinases
    C Hugh Reynolds
    The MRC Centre for Neurodegeneration Research, King s College London, Institute of Psychiatry, London, UK
    J Biol Chem 283:18177-86. 2008
    ....
  5. doi Phospholipid scramblase 1 modulates a selected set of IgE receptor-mediated mast cell responses through LAT-dependent pathway
    Omid Amir-Moazami
    INSERM U699, and Faculté de Médecine Xavier Bichat, Universite Paris 7, 16 rue Henri Huchard, Paris, France
    J Biol Chem 283:25514-23. 2008
    ..Altogether, these data identify PLSCR1 as a novel amplifier of FcepsilonRI signaling that acts selectively on the Lyn-initiated LAT/phospholipase Cgamma1/calcium axis, resulting in potentiation of a selected set of mast cell responses...
  6. ncbi CAIR-1/BAG-3 forms an EGF-regulated ternary complex with phospholipase C-gamma and Hsp70/Hsc70
    H Doong
    Molecular Signaling Section, Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland, MD 20892, USA
    Oncogene 19:4385-95. 2000
    ..We propose that CAIR-1/BAG-3 may act as a multifunctional signaling protein linking the Hsp70/Hsc70 pathway with those necessary for activation of the EGF receptor tyrosine kinase signaling pathways...
  7. ncbi The phosphorylated 1169-tyrosine containing region of flt-1 kinase (VEGFR-1) is a major binding site for PLCgamma
    A Sawano
    Institute of Medical Science, University of Tokyo, Minato ku, Tokyo, 108, Japan
    Biochem Biophys Res Commun 238:487-91. 1997
    ..These results strongly suggest that Tyr-1169 on Flt-1 is a major binding site for PLCgamma and important for Flt-1 signal transduction within the cell...
  8. ncbi Discoidin domain receptor 1 (DDR1) signaling in PC12 cells: activation of juxtamembrane domains in PDGFR/DDR/TrkA chimeric receptors
    E D Foehr
    Departments of Physiology and Biophysics, College of Medicine, University of California, Irvine, California 92697 4560, USA
    FASEB J 14:973-81. 2000
    ..These findings suggest that the DDR1 receptors do have signaling capacity but may require additional components or altered conditions to fully activate their kinase domains and/or sustain the activation of the JM sites...
  9. pmc A phospholipase Cγ1-activated pathway regulates transcription in human vascular smooth muscle cells
    Irene Hunter
    School of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Cardiovasc Res 90:557-64. 2011
    ..The mediators involved in ERK1/2 nuclear translocation in VSM cells are unknown. The aim of this study is to examine the mechanisms which regulate growth factor-induced nuclear translocation of ERK1/2 and gene expression in VSM cells...
  10. doi Downregulation of erythropoietin receptor by overexpression of phospholipase C-gamma 1 is critical for decrease on focal adhesion in transformed cells
    Jin Ku Kang
    Department of Life Science, College of Natural Science, Daejin University, Pochen, Gyeonggido, South Korea
    Cell Oncol (Dordr) 34:11-21. 2011
    ..Here, we assessed the role of EpoR-dependent signaling pathways in PLC-γl-dependent regulation of cell adhesion and migration...
  11. pmc ESCRT machinery potentiates HIV-1 utilization of the PI(4,5)P(2)-PLC-IP3R-Ca(2+) signaling cascade
    Lorna S Ehrlich
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794 5222, USA
    J Mol Biol 413:347-58. 2011
    ..The results suggest that L domain function, ESCRT machinery and Ca(2+) signaling are linked events in Gag release...
  12. pmc A novel regulatory mechanism links PLCγ1 to PDK1
    Claudio Raimondi
    Centre for Diabetes, Blizard Institute, Queen Mary University of London, Barts and the London School of Medicine and Dentistry, London, UK
    J Cell Sci 125:3153-63. 2012
    ..This is likely to have profound consequences for our understanding of several cellular functions that are dependent on phosphoinositides and controlled by PDK1 and PLCγ1...
  13. pmc Vav1 oncogenic mutation inhibits T cell receptor-induced calcium mobilization through inhibition of phospholipase Cγ1 activation
    Mira Knyazhitsky
    Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    J Biol Chem 287:19725-35. 2012
    ..The oncogenic truncation of this region elicits conformational changes that interfere with the Vav1-mediated activation of PLCγ1 and that inhibit calcium mobilization...
  14. doi Overexpression of activated phospholipase Cγ1 is a risk factor for distant metastases in T1-T2, N0 breast cancer patients undergoing adjuvant chemotherapy
    Rossano Lattanzio
    Department of Biomedical Sciences, University G D Annunzio, Chieti, Italy
    Int J Cancer 132:1022-31. 2013
    ..Thus, targeting PLCγ1 pathways might represent a potential therapeutic approach for the prevention of metastatic disease in breast cancer...
  15. doi Competition between Grb2 and Plcγ1 for FGFR2 regulates basal phospholipase activity and invasion
    Zahra Timsah
    Department of Biochemistry and Molecular Biology, University of Texas, M D Anderson Cancer Center, Houston, Texas, USA
    Nat Struct Mol Biol 21:180-8. 2014
    ..Therefore, metastatic outcome can be dictated by the constitutive competition between Grb2 and Plcγ1 for the phosphorylation-independent binding site on FGFR2. ..
  16. pmc A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway regulates fibroblast growth factor-induced capillary tube formation
    Tania Maffucci
    Queen Mary University of London, Barts and the London School of Medicine and Dentistry, Blizard Institute of Cell and Molecular Science, Centre for Diabetes, Inositide Signalling Group, London, United Kingdom
    PLoS ONE 4:e8285. 2009
    ..Here we investigated the basic FGF (FGF-2)-mediated activation of these enzymes in human umbilical vein endothelial cells (HUVECs) and defined their role in FGF-2-dependent cellular functions...
  17. pmc A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1
    M Mohammadi
    Department of Pharmacology, New York University Medical Center, New York 10016
    Mol Cell Biol 11:5068-78. 1991
    ..We propose that homologous tyrosine-phosphorylated regions in other FGFRs also function as binding sites for PLC-gamma and therefore are involved in coupling to phosphatidylinositol breakdown...
  18. ncbi Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses
    R M Stephens
    ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Maryland 21702
    Neuron 12:691-705. 1994
    ..These results suggest a model whereby Trk receptors utilize at least partially redundant signal transduction pathways to mediate NGF responses...
  19. ncbi Differential association of cytoplasmic signalling molecules SHP-1, SHP-2, SHIP and phospholipase C-gamma1 with PECAM-1/CD31
    N J Pumphrey
    Division of Immunity and Infection, University of Birmingham, UK
    FEBS Lett 450:77-83. 1999
    ....
  20. ncbi Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1
    C Zhao
    Department of Biochemistry and Molecular Biology, and Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana 46202 5254, USA
    J Biol Chem 274:19649-54. 1999
    ..This is the first evidence that an intracellular molecule with a PH domain operates as a negative effector in signal relay to the regulation of gene expression...
  21. ncbi Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat
    N J Haughey
    Department of Pharmacology and Therapeutics, University of Manitoba Faculty of Medicine, Winnipeg, Canada
    J Neurochem 73:1363-74. 1999
    ....
  22. ncbi Differential role of Janus family kinases (JAKs) in interferon-gamma-induced lung epithelial ICAM-1 expression: involving protein interactions between JAKs, phospholipase Cgamma, c-Src, and STAT1
    Ya Jen Chang
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Mol Pharmacol 65:589-98. 2004
    ..One is the JAK1/2-dependent PLC-gamma pathway inducing the activations of PKCalpha, c-Src, and STAT1, and the other is the direct activation of STAT1 by JAK1/2...
  23. ncbi Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia
    Chang Gyu Hahn
    Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Med 12:824-8. 2006
    ..Therefore, these findings suggest that enhanced NRG1 signaling may contribute to NMDA hypofunction in schizophrenia...
  24. ncbi On/off-regulation of phospholipase C-gamma 1-mediated signal transduction
    Jang Hyun Choi
    National Research Laboratory of Signaling Network, Department of Life Science, Pohang University of Science and Technology, Pohang, Kyungbuk 790 784, Republic of Korea
    Adv Enzyme Regul 47:104-16. 2007
  25. pmc Combined inhibition of PLC{gamma}-1 and c-Src abrogates epidermal growth factor receptor-mediated head and neck squamous cell carcinoma invasion
    Hiroshi Nozawa
    Department of Oral and Maxillofacial Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan
    Clin Cancer Res 14:4336-44. 2008
    ..The purpose of this study was to investigate the efficacy of combined inhibition of c-Src and PLCgamma-1 in the abrogation of HNSCC invasion...
  26. pmc Phosphorylation of Nephrin Triggers Ca2+ Signaling by Recruitment and Activation of Phospholipase C-{gamma}1
    Yutaka Harita
    Division of Cellular Proteomics BML and Department of Oncology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Biol Chem 284:8951-62. 2009
    ..Given the profound effect of PLC-gamma in diverse cellular functions, regulation of the Ca(2+) signaling by Nephrin may be important in modulating the glomerular filtration barrier function...
  27. pmc Human immunodeficiency virus type 1 envelope gp120-induced partial T-cell receptor signaling creates an F-actin-depleted zone in the virological synapse
    Gaia Vasiliver-Shamis
    Program in Molecular Pathogenesis, Marty and Helen Kimmel Center for Biology and Medicine, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    J Virol 83:11341-55. 2009
    ..We propose a model in which the F-actin-depleted zone formed within the target CD4 T cell enhances the reception of virions by releasing the physical barrier for HIV-1 entry and facilitating postentry events...
  28. pmc Chemokine coreceptor signaling in HIV-1 infection and pathogenesis
    Yuntao Wu
    Department of Molecular and Microbiology, George Mason University, Manassas, Virginia, USA
    PLoS Pathog 5:e1000520. 2009
    ..In this review, we summarize past and present studies on HIV coreceptor signaling. We also discuss possible roles of coreceptor signaling in facilitating viral infection and pathogenesis...
  29. doi The HIV-1 Nef protein has a dual role in T cell receptor signaling in infected CD4+ T lymphocytes
    Francesca Neri
    Laboratory of Immunoinfectivology, Children s Hospital Bambino Gesu, 00165 Rome, Italy
    Virology 410:316-26. 2011
    ..Our data indicate that Nef has a dual role in the modulation of TCR signaling aimed at favoring HIV-1 replication and spread in both quiescent and metabolically active CD4(+) T lymphocytes...
  30. doi The interplay of HER2/HER3/PI3K and EGFR/HER2/PLC-γ1 signalling in breast cancer cell migration and dissemination
    Lydia M Balz
    Institute of Immunology, Witten Herdecke University, Germany
    J Pathol 227:234-44. 2012
    ..Moreover, our data further show that primary tumour cells and DTCs can vary in their HER activation status, which is important to know in the context of cancer therapy...
  31. ncbi Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors
    T G Boulton
    Regeneron Pharmaceuticals, Inc, Tarrytown, New York 10591
    J Biol Chem 269:11648-55. 1994
    ..Our data suggest the beta receptor components can form complexes with some of the signaling proteins identified and may play some role in their recruitment...
  32. ncbi Cytoskeletal association of epidermal growth factor receptor and associated signaling proteins is regulated by cell density in IEC-6 intestinal cells
    M S Bedrin
    Department of Pediatrics, University of Miami School of Medicine, Florida, USA
    J Cell Physiol 172:126-36. 1997
    ..Thus, cell density regulates the CSK association of the EGFR and its ability to associate and activate signaling pathways in intestinal cells...
  33. ncbi Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells
    T B van Dijk
    Institute of Hematology, Erasmus University Rotterdam, Rotterdam, The Netherlands
    Blood 96:3406-13. 2000
    ..These findings suggest that p62Dok-1 may function as an important scaffold molecule in cKit-mediated signaling...
  34. ncbi Tec kinases mediate sustained calcium influx via site-specific tyrosine phosphorylation of the phospholipase Cgamma Src homology 2-Src homology 3 linker
    Lisa A Humphries
    Molecular Biology Institute and Department of Microbiology and Immunology, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 279:37651-61. 2004
    ..Together, these data support a model whereby Btk/Tec kinases control sustained calcium signaling via site-specific phosphorylation of key residues within the PLCgamma2 SH2-SH3 linker...
  35. pmc Elevated content of the tyrosine kinase substrate phospholipase C-gamma 1 in primary human breast carcinomas
    C L Arteaga
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232
    Proc Natl Acad Sci U S A 88:10435-9. 1991
    ....
  36. ncbi A single point mutation switches the specificity of group III Src homology (SH) 2 domains to that of group I SH2 domains
    Z Songyang
    Division of Signal Transduction, Beth Israel Hospital, Boston, Massachusetts, USA
    J Biol Chem 270:26029-32. 1995
    ..These results establish the importance of the beta D5 residue in determining specificities of SH2 domains...
  37. pmc Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk
    C L Law
    Department of Microbiology, University of Washington, Seattle, USA
    Mol Cell Biol 16:1305-15. 1996
    ..Thus, an optimal kinase activity of Syk and an interaction between the linker region of Syk with PLC-gamma1 are required for the tyrosyl phosphorylation of PLC-gamma1...
  38. ncbi A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs
    K Matuoka
    Department of Biosignal Research, Tokyo Metropolitan Institute of Gerontology, Japan
    Biochem Biophys Res Commun 239:488-92. 1997
    ..In addition, NAP4 bore a putative nuclear localization signal and a Q-run/P-run composite, both characteristic of nuclear proteins, and might therefore relate to the presence of Nck in the cellular nucleus...
  39. ncbi BLNK: a central linker protein in B cell activation
    C Fu
    Center for Immunology, Program in Molecular Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Immunity 9:93-103. 1998
    ..Hence, BLNK represents a central linker protein that bridges the B cell receptor-associated kinases with a multitude of signaling pathways and may regulate the biologic outcomes of B cell function and development...
  40. ncbi Sequences surrounding the Src-homology 3 domain of phospholipase Cgamma-1 increase the domain's association with Cbl
    L J Graham
    Division of Monoclonal Antibodies, US Food and Drug Administration, Bethesda, Maryland, 20852, USA
    Biochem Biophys Res Commun 249:537-41. 1998
    ..Cbl is an adapter-like protein known to interact with several SH3 domains, including the PLCgamma1 SH3 domain and the Grb2 amino terminal SH3 domain...
  41. ncbi LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation
    W Zhang
    Section on Lymphocyte Signaling, Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 5430, USA
    Immunity 9:239-46. 1998
    ..LAT is central to T cell activation and is a novel linker molecule shown to require targeting to membrane microdomains for signaling...
  42. ncbi A role for phospholipase C-gamma-mediated signaling in tumor cell invasion
    J Kassis
    Birmingham Veterans Administration Medical Center, Department of Pathology, University of Alabama at Birmingham, 35294 0007, USA
    Clin Cancer Res 5:2251-60. 1999
    ..In all situations, the inhibition of PLCgamma signaling did not decrease mitogenic signaling. Thus, the motility-associated PLCgamma signaling pathway is a generalizable rate-limiting step for tumor cell progression...
  43. ncbi Tyrosine 766 in the fibroblast growth factor receptor-1 is required for FGF-stimulation of phospholipase C, phospholipase D, phospholipase A(2), phosphoinositide 3-kinase and cytoskeletal reorganisation in porcine aortic endothelial cells
    M J Cross
    Department of Genetics, Rudbeck Laboratory, S 75185 Uppsala, Sweden
    J Cell Sci 113:643-51. 2000
    ..Furthermore, whilst tyrosine 766 was not required for a proliferative response, it was required for fibroblast growth factor receptor-1 mediated cytoskeletal reorganisation...
  44. ncbi Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling
    W Zhang
    Laboratory of Cellular and Molecular Biology, Division of Basic Sciences, NCI, National Institutes of Health, Bethesda, Maryland 20892 4255, USA
    J Biol Chem 275:23355-61. 2000
    ..Mutation of individual Grb2 binding sites had no functional effect, but mutation of two or three of these sites, in combination, also affected Erk and NF-AT activation...
  45. ncbi PLC-gamma1 enzyme activity is required for insulin-induced DNA synthesis
    Jens Eichhorn
    Medical Research Service, San Diego Veterans Affairs Healthcare System, San Diego, California 92161, USA
    Endocrinology 143:655-64. 2002
    ..These experimental data point to a requirement for PLC-gamma1 in insulin-stimulated mitogenesis in hIRcB cells...
  46. ncbi Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE
    Keqiang Ye
    Johns Hopkins University School of Medicine, Department of Neuroscience, 725 N Wolfe Street, Baltimore, Maryland 21205, USA
    Nature 415:541-4. 2002
    ..This enzymatic activity accounts for the mitogenic properties of PLC-gamma 1...
  47. ncbi Interaction of elongation factor-1alpha and pleckstrin homology domain of phospholipase C-gamma 1 with activating its activity
    Jong Soo Chang
    Department of Life Science, College of Natural Science, Daejin University, Kyeonggido 487 711, Korea
    J Biol Chem 277:19697-702. 2002
    ..Taken together, our data show that EF-1alpha plays a direct role in phosphoinositide metabolism of cellular signaling by regulating PLC-gamma1 activity via a split PH domain...
  48. ncbi Mechanism of tyrosine phosphorylation and activation of phospholipase C-gamma 1. Tyrosine 783 phosphorylation is not sufficient for lipase activation
    Fujio Sekiya
    Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:32181-90. 2004
    ..Finally, concurrent production of phosphatidylinositol 3,4,5-trisphosphate was found to contribute to the activation of phosphorylated PLC-gamma 1...
  49. ncbi PLCgamma1 is essential for early events in integrin signalling required for cell motility
    Neil P Jones
    Cancer Research UK Centre for Cell and Molecular Biology, Chester Beatty Laboratories, The Institute of Cancer Research, London, UK
    J Cell Sci 118:2695-706. 2005
    ..One potential signalling intermediate, PLCgamma1, has previously been implicated in growth-factor-mediated chemotaxis but its position and roles in more-complex ..
  50. ncbi The isoforms of phospholipase C-gamma are differentially used by distinct human NK activating receptors
    Jadee L Upshaw
    Department of Immunology, and Division of Oncology Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Immunol 175:213-8. 2005
    ..More broadly, these observations reveal a basis for selectively targeting the functions initiated by distinct immune recognition receptors...
  51. ncbi Stromal-cell-derived factor-1/CXCL12-induced chemotaxis of a T cell line involves intracellular signaling through Cbl and Cbl-b and their regulation by Src kinases and CD45
    Seiichi Okabe
    Department of Microbiology Immunology and Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Blood Cells Mol Dis 36:308-14. 2006
    ..Our results implicate CD45, Cbl, Cbl-b, src kinases and potentially other associated proteins as mediators of SDF-1alpha/CXCL12-induced cell migration of Jurkat T cells...
  52. pmc A critical role for the E3-ligase activity of c-Cbl in VEGFR-2-mediated PLCgamma1 activation and angiogenesis
    Amrik J Singh
    Department of Periodontology, Boston University Medical School, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 104:5413-8. 2007
    Activation of phospholipase Cgamma1 (PLCgamma1) by vascular endothelial growth factor receptor-2 (VEGFR-2) in endothelial cells in part is responsible for angiogenesis in vivo...
  53. ncbi Role of phospholipase Cgamma-induced activation of protein kinase Cepsilon (PKCepsilon) and PKCbetaI in epidermal growth factor-mediated protection of tight junctions from acetaldehyde in Caco-2 cell monolayers
    Takuya Suzuki
    Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 283:3574-83. 2008
    ..inulin permeability, and subcellular redistribution of occludin and ZO-1 was attenuated by reduced expression of PLCgamma1 by short hairpin RNA...
  54. doi Phospholipase Cgamma1 is required for metastasis development and progression
    Gianluca Sala
    Inositide Signalling Group, Centre for Diabetes and Metabolic Medicine, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, London, United Kingdom
    Cancer Res 68:10187-96. 2008
    ..Evidence suggests that the enzyme phospholipase Cgamma1 (PLCgamma1) may be involved in tumor progression and possibly development of metastasis...
  55. doi PLC-gamma1 and Rac1 coregulate EGF-induced cytoskeleton remodeling and cell migration
    Siwei Li
    Department of Cell Biology, University of Alberta, Edmonton, Canada
    Mol Endocrinol 23:901-13. 2009
    ..We conclude that PLC-gamma1 and Rac1 coregulate EGF-induced cell cytoskeleton remodeling and cell migration by a direct functional interaction...
  56. pmc Inhibition and activation by CD244 depends on CD2 and phospholipase C-gamma1
    Nicholas G Clarkson
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
    J Biol Chem 284:24725-34. 2009
    ..We identify a novel signaling mechanism for CD244 through its potential to recruit phospholipase C-gamma1 via the conserved phosphorylated tyrosine motif in the tail of the adaptor protein EAT-2, which we show is important for function...
  57. pmc Structural and functional integration of the PLCγ interaction domains critical for regulatory mechanisms and signaling deregulation
    Tom D Bunney
    Institute of Structural and Molecular Biology, Division of Biosciences, University College London, Gower Street, London WC1E 6BT, UK
    Structure 20:2062-75. 2012
    ....
  58. ncbi Tyrosine residues in bovine phospholipase C-gamma phosphorylated by the epidermal growth factor receptor in vitro
    J W Kim
    Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 265:3940-3. 1990
    ..We propose, therefore, that the phosphorylation of PLC-gamma by EGF receptor kinase alters its interaction with putative inhibitory proteins and leads to its activation...
  59. ncbi Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line
    G Zauli
    Institute of Human Anatomy, University of Ferrara, Italy
    Eur J Immunol 25:2695-700. 1995
    ..The relevance of these findings for a better understanding of the biological functions of extracellular Tat is discussed...
  60. ncbi HIV-1 glycoprotein gp120 disrupts CD4-p56lck/CD3-T cell receptor interactions and inhibits CD3 signaling
    P Hubert
    Laboratoire d Immunologie Cellulaire et Tissulaire, CNRS URA 625, Paris, France
    Eur J Immunol 25:1417-25. 1995
    ..Supporting this hypothesis, gp120 inhibits CD3-linked kinase activity as shown by the inhibition of the phosphorylation of CD3 chains, leading to the inhibition of subsequent signal transduction...
  61. pmc Association of p62, a multifunctional SH2- and SH3-domain-binding protein, with src family tyrosine kinases, Grb2, and phospholipase C gamma-1
    S Richard
    Center for Immunology, Washington University School of Medicine, St Louis, Missouri 63110
    Mol Cell Biol 15:186-97. 1995
    ....
  62. pmc Tyrosine phosphorylation of Grb2-associated proteins correlates with phospholipase C gamma 1 activation in T cells
    D G Motto
    Department of Physiology and Biophysics, University of Iowa College of Medicine, Iowa City 52242, USA
    Mol Cell Biol 16:2823-9. 1996
    ....
  63. ncbi IL-13 induces tyrosine phosphorylation of phospholipase C gamma-1 following IRS-2 association in human monocytes: relationship with the inhibitory effect of IL-13 on ROI production
    P Sozzani
    Laboratoire de l Université P Sabatier, CHU Rangueil, Toulouse, France
    Biochem Biophys Res Commun 244:665-70. 1998
    ..We demonstrate for the first time that IL-13 induces the association of IRS-2 with PLC-gamma 1. We proposed here that PLC-gamma 1 is a new candidate recruited by IRS-2...
  64. ncbi Association of the insulin receptor with phospholipase C-gamma (PLCgamma) in 3T3-L1 adipocytes suggests a role for PLCgamma in metabolic signaling by insulin
    A G Kayali
    UCSD Whittier Diabetes Program, University of California San Diego, La Jolla, California 92093 and the Medical Research Service, Department of Veterans Affairs, Medical Center, San Diego, California 92161, USA
    J Biol Chem 273:13808-18. 1998
    ..We conclude that PLCgamma is an active participant in metabolic and perhaps mitogenic signaling by the insulin receptor in 3T3-L1 adipocytes...
  65. ncbi Signaling properties of VEGF receptor-1 and -2 homo- and heterodimers
    K Huang
    Rudbeck Laboratory, Department of Genetics and Pathology, Uppsala University, S 751 85, Uppsala, Sweden
    Int J Biochem Cell Biol 33:315-24. 2001
    ..The pattern of Ca2+ fluxes was unique for each type of VEGF receptor dimer. Our data show that signal transduction induced by VEGF-A is transduced in distinct manners by homo- and heterodimers of VEGF receptors...
  66. ncbi EGF-dependent association of phospholipase C-gamma1 with c-Cbl
    Denis Tvorogov
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Exp Cell Res 277:86-94. 2002
    ..The data, therefore, show an EGF-inducible direct association of PLC-gamma1 with c-Cbl in vivo that is mediated by the SH3 domain of PLC-gamma1...
  67. ncbi Munc-18-1 inhibits phospholipase D activity by direct interaction in an epidermal growth factor-reversible manner
    Hye Young Lee
    Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, 790 784 Republic of Korea
    J Biol Chem 279:16339-48. 2004
    ..These results suggest that Munc-18-1 is a potent negative regulator of basal PLD activity and that EGF stimulation abolishes this interaction...
  68. ncbi Phospholipase C-gamma1 is a guanine nucleotide exchange factor for dynamin-1 and enhances dynamin-1-dependent epidermal growth factor receptor endocytosis
    Jang Hyun Choi
    Division of Molecular and Life Science, Pohang University of Science and Technology, San 31, Hyojadong, Pohang, Kyungbuk 790 784, Republic of Korea
    J Cell Sci 117:3785-95. 2004
    ..These results establish a new role for PLC-gamma1 in the regulation of endocytosis and suggest that endocytosis of activated EGF receptors may mediate PLC-gamma1-dependent proliferation...
  69. ncbi Atypical mechanism of regulation of the Wrch-1 Rho family small GTPase
    Adam Shutes
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Curr Biol 14:2052-6. 2004
    ..We propose that Grb2 overcomes N-terminal negative regulation to promote Wrch-1 effector interaction. Thus, Wrch-1 exhibits an atypical model of regulation not seen in other Rho family GTPases...
  70. ncbi Phospholipase C gamma 1 regulates the Rap GEF1-Rap1 signalling axis in the control of human prostate carcinoma cell adhesion
    J C Peak
    Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, Sutton, UK
    Oncogene 27:2823-32. 2008
    Phospholipase Cgamma1 (PLCgamma1) is activated downstream of a variety of extracellular stimuli and has previously been implicated in the regulation of motility responses central to tumour cell invasion...
  71. pmc c-Cbl inhibits angiogenesis and tumor growth by suppressing activation of PLCγ1
    R D Meyer
    Department of Pathology, Boston University Medical Campus, Boston, MA 02118, USA
    Oncogene 30:2198-206. 2011
    ..Hence, we propose c-Cbl as an angiogenic suppressor protein where upon activation it uniquely modulates PLCγ1 activation by ubiquitination and subsequently inhibits VEGF-driven angiogenesis...
  72. pmc Stromal cell-derived factor-1 signaling via the CXCR4-TCR heterodimer requires phospholipase C-β3 and phospholipase C-γ1 for distinct cellular responses
    Kimberly N Kremer
    Department of Immunology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 187:1440-7. 2011
    ....
  73. pmc Akt and phospholipase Cγ are involved in the regulation of growth and migration of MDA-MB-468 breast cancer and SW480 colon cancer cells when cultured with diabetogenic levels of glucose and insulin
    Nicola M Tomas
    Institute of Immunology and Experimental Oncology, Witten Herdecke University, Stockumer Str, 10, D 58448, Witten, Germany
    BMC Res Notes 5:214. 2012
    ..Therefore, we examined regulatory functions and expression of Akt and PLCγ in a simplified in vitro diabetogenic model...
  74. ncbi Identification of two tyrosine phosphoproteins, pp70 and pp68, which interact with phospholipase Cgamma, Grb2, and Vav after B cell antigen receptor activation
    C Fu
    Program in Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 272:27362-8. 1997
    ..tyrosine-phosphorylated proteins with Mr values of 70,000 and 68,000 that interact with Grb2, phospholipase C (PLCgamma1 and PLCgamma2), and Vav after B cell receptor cross-linking...
  75. ncbi Identification of regions of the Wiskott-Aldrich syndrome protein responsible for association with selected Src homology 3 domains
    P M Finan
    Yamanouchi Research Institute, Littlemore Hospital, Oxford OX4 4XN, United Kingdom
    J Biol Chem 271:26291-5. 1996
    ....
  76. ncbi A new function for phospholipase C-gamma1: coupling to the adaptor protein GRB2
    Z Pei
    School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Arch Biochem Biophys 345:103-10. 1997
    ....
  77. ncbi Specificity of the binding of synapsin I to Src homology 3 domains
    F Onofri
    Department of Experimental Medicine, Section of Physiology, University of Genova, Via Benedetto XV 3, I 16132 Genova, Italy
    J Biol Chem 275:29857-67. 2000
    ..The ability to bind multiple SH3 domains further implicates the synapsins in signal transduction and protein-protein interactions at the nerve terminal level...
  78. ncbi Direct interaction of SOS1 Ras exchange protein with the SH3 domain of phospholipase C-gamma1
    M J Kim
    Department of Life Science and School of Environmental Engineering, Pohang University of Science and Technology, Republic of Korea
    Biochemistry 39:8674-82. 2000
    ..This study is the first to demonstrate that the PLC-gamma1 SH3 domain enhances p21Ras activity, and that the SH3 domain of PLC-gamma1 may be involved in the SOS1-mediated signaling pathway...
  79. ncbi Regulation of B-cell activation and differentiation by the phosphatidylinositol 3-kinase and phospholipase Cgamma pathway
    A J Marshall
    Department of Microbiology, University of Washington, Seattle, USA
    Immunol Rev 176:30-46. 2000
    ..Taken together, the present data clearly indicate that PI3K and PLCgamma play critical and indispensable roles in the signal transduction cascades leading to multiple biological responses downstream of the BCR...
  80. ncbi The recruitment of phosphatidylinositol 3-kinase to the E-cadherin-catenin complex at the plasma membrane is required for calcium-induced phospholipase C-gamma1 activation and human keratinocyte differentiation
    Zhongjian Xie
    Endocrine Unit, Veterans Affairs Medical Center, Northern California Institute for Research and Education and University of California, San Francisco, California 94121, USA
    J Biol Chem 282:8695-703. 2007
    ....
  81. ncbi The role of intranuclear lipids
    E Albi
    Department of Biochemical Sciences and Molecular Biotechnology, Physiopathology, Policlinico Monteluce, 06100 Perugia, Italy
    Biol Cell 96:657-67. 2004
    ..last effect is due to the action of two enzymes: PI-PLCss1 having a role in the onset of DNA synthesis and PC-PLCgamma1 acting in G2 transit...
  82. ncbi Potent SHC tyrosine phosphorylation by epidermal growth factor at low receptor density or in the absence of receptor autophosphorylation sites
    C Soler
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146
    Oncogene 9:2207-15. 1994
    ....
  83. doi Tumor necrosis factor-alpha enhances neutrophil adhesiveness: induction of vascular cell adhesion molecule-1 via activation of Akt and CaM kinase II and modifications of histone acetyltransferase and histone deacetylase 4 in human tracheal smooth muscle c
    Chiang Wen Lee
    Department of Physiology and Pharmacology, Chang Gung University, 259 Wen Hwa 1st Road, Kwei San, Tao Yuan, Taiwan
    Mol Pharmacol 73:1454-64. 2008
    ..Blockade of these pathways may be selectively targeted to reduce neutrophil adhesion via VCAM-1 suppression and attenuation of the inflammatory responses in airway diseases...
  84. ncbi Analysis of platelet-derived growth factor-induced phospholipase D activation in mouse embryo fibroblasts lacking phospholipase C-gamma1
    J A Hess
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0295, USA
    J Biol Chem 273:20517-24. 1998
    ..In summary, these data indicate that PLC-gamma is required for growth factor-induced activation of PLD in MEFs...
  85. ncbi A cyclic adenosine 3',5'-monophosphate stimulates phospholipase Cgamma1-calcium signaling via the activation of tyrosine kinase in boar spermatozoa
    Hiroshi Harayama
    Graduate School of Science and Technology, Kobe University, Nada, Kobe 657 8501, Japan
    J Androl 26:732-40. 2005
    ..1 mM). Moreover, the cAMP-dependent tyrosine phosphorylation was also induced at the key regulatory residue of PLCgamma1 in the same segments of spermatozoa, but it was inhibited by the addition of herbimycin A (a tyrosine kinase ..
  86. pmc Genetic and biochemical characterization of a phosphatidylinositol-specific phospholipase C in Saccharomyces cerevisiae
    J S Flick
    Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Mol Cell Biol 13:5861-76. 1993
    ..The polymerase chain reaction was used to isolate a Saccharomyces cerevisiae gene (PLC1) that encodes a protein of 869 amino acids (designated Plc1p) that bears greatest resemblance to the delta isoforms ..
  87. ncbi Cloning and characterization of a gene encoding phosphatidyl inositol-specific phospholipase C from Trypanosoma cruzi
    T Nozaki
    Department of Parasitology, National Institute of Infectious Diseases, Tokyo, Japan
    Mol Biochem Parasitol 102:283-95. 1999
    ..The tetrad analysis of the segregants of the Saccharomyces cerevisiae PLC1/plc1::HIS3 diploid strain transformed with the T. cruzi PLC-expressing plasmid showed that expression of T...
  88. doi Phosphoinositide-phospholipase C beta1 mono-allelic deletion is associated with myelodysplastic syndromes evolution into acute myeloid leukemia
    Matilde Y Follo
    Department of Human Anatomical Sciences, Cellular Signalling Laboratory, University of Bologna, Bologna, Italy
    J Clin Oncol 27:782-90. 2009
    ..To evaluate the association between the presence of phosphoinositide-phospholipase C beta1 (PI-PLCbeta1) mono-allelic deletion with the clinical outcome of myelodysplastic syndromes (MDS) patients...
  89. pmc Saccharomyces cerevisiae phospholipase C regulates transcription of Msn2p-dependent stress-responsive genes
    Agnieszka Demczuk
    Department of Biological Sciences, St John s University, 8000 Utopia Parkway, Queens, NY 11439, USA
    Eukaryot Cell 7:967-79. 2008
    ..Most of these genes are induced by nutrient limitation and other environmental stresses and are derepressed in plc1 Delta cells...
  90. pmc Bile acid reflux contributes to development of esophageal adenocarcinoma via activation of phosphatidylinositol-specific phospholipase Cgamma2 and NADPH oxidase NOX5-S
    Jie Hong
    Department of Medicine, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
    Cancer Res 70:1247-55. 2010
    ..PI-PLCbeta1, PI-PLCbeta3, PI-PLCbeta4, PI-PLCgamma1, and PI-PLCgamma2, but not PI-PLCbeta2 and PI-PLCdelta1, were detectable in FLO cells by Western blot analysis...
  91. ncbi Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2
    D Park
    Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 267:16048-55. 1992
    ..see also accompanying article (Lee, C. H., Park, D., Wu, D., Rhee, S. G., and Simon, M. I. (1992) J. Biol. Chem. 267, 16044-16047)...
  92. ncbi Association of p72syk with the src homology-2 (SH2) domains of PLC gamma 1 in B lymphocytes
    A L Sillman
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    J Biol Chem 270:11806-11. 1995
    ..We have used a fusion protein containing the tandem src homology-2 (SH2) domains of phospholipase C gamma 1 (PLC gamma 1) to identify B cell kinases which associate with PLC gamma 1...
  93. ncbi Impaired antigen receptor induced calcium mobilization in a phospholipase C-gamma1 deficient B cell line
    Natarajan Muthusamy
    Center for Molecular and Human Genetics, The Department of Pediatrics, Columbus Children s Research Institute, The Ohio State University Columbus, OH 43205, USA
    Immunol Lett 90:203-7. 2003
    ..The possible use for L1.2 cells in testing the regulation of PLC-gamma(1) and PLC-gamma(2) dependent calcium mobilization in B lymphocytes is discussed...
  94. ncbi The role of phospholipase C gamma 1 in primitive hematopoiesis during zebrafish development
    Alvin C H Ma
    Division of Hematology and Bone Marrow Transplantation, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China
    Exp Hematol 35:368-73. 2007
    ..However, its role in hematopoiesis during embryonic development is currently unclear. In this study, we examined this issue using morpholino (MO) gene knockdown in zebrafish embryos..
  95. ncbi The phosphoinositide-phospholipase C (PI-PLC) pathway in the mouse oocyte
    Brigitte Lefevre
    INSERM U566 CEA DRR LGAG Univ Paris 7, Batiment 05, Route du Panorama, F 92260, Fontenay aux Roses, France
    Crit Rev Eukaryot Gene Expr 17:259-69. 2007
    ..Such anomalies can prevent the production of competent oocytes and lead to fertility problems...
  96. pmc The SH2/SH3 domain-containing protein Nck is recognized by certain anti-phospholipase C-gamma 1 monoclonal antibodies, and its phosphorylation on tyrosine is stimulated by platelet-derived growth factor and epidermal growth factor treatment
    J Meisenhelder
    Molecular Biology and Virology Laboratory, Salk Institute, San Diego, California 92186
    Mol Cell Biol 12:5843-56. 1992
    ....
  97. ncbi Prostaglandin E2 stimulates fibronectin expression through EP1 receptor, phospholipase C, protein kinase Calpha, and c-Src pathway in primary cultured rat osteoblasts
    Chih Hsin Tang
    Departments of Pharmacology and Orthopaedics, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Biol Chem 280:22907-16. 2005
    ..Taken together, our results provided evidence that PGE(2) increased Fn and promoted bone formation in rat osteoblasts via the EP(1)/phospholipase C/PKCalpha/c-Src signaling pathway...
  98. ncbi Phospholipase C expression and activity in smooth muscle cells of renal arterioles and aorta of young, spontaneously hypertensive rats during culture
    Zhangping Peng
    Department of Cell and Molecular Physiology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7545, USA
    Am J Hypertens 20:520-6. 2007
    ..We assessed the stability of variables over passages 3 to 11...
  99. pmc Characterization of phospholipase C gamma enzymes with gain-of-function mutations
    Katy L Everett
    Section of Cell and Molecular Biology, Chester Beatty Laboratories, The Institute of Cancer Research, London SW3 6JB, United Kingdom
    J Biol Chem 284:23083-93. 2009
    Phospholipase C gamma isozymes (PLC gamma 1 and PLC gamma 2) have a crucial role in the regulation of a variety of cellular functions. Both enzymes have also been implicated in signaling events underlying aberrant cellular responses...
  100. ncbi Drosophila phospholipase C-gamma expressed predominantly in blastoderm cells at cellularization and in endodermal cells during later embryonic stages
    Y Emori
    Department of Biophysics and Biochemistry, Faculty of Science, University of Tokyo, Japan
    J Biol Chem 269:19474-9. 1994
    ....
  101. ncbi Collagen stimulates tyrosine phosphorylation of phospholipase C-gamma 2 but not phospholipase C-gamma 1 in human platelets
    R A Blake
    Department of Pharmacology, Oxford, UK
    FEBS Lett 353:212-6. 1994
    ..In contrast, we could not detect phospholipase C-gamma 2 tyrosine phosphorylation in platelets stimulated by either thrombin or a stable thromboxane A2 analogue, U46619...

Research Grants55

  1. PHOSPHOLIPASE C GAMMA 1--BIOCHEMISTRY AND BIOLOGY
    Graham Carpenter; Fiscal Year: 2006
    The major focus of this grant application is phospholipase C-gamma1(PLCgamma1), a substrate of nearly all receptor and some non-receptor tyrosine kinases...
  2. Regulation of T Cell Signaling: Structural Studies of PLCgamma1
    Amy H Andreotti; Fiscal Year: 2012
    ..Thus, the public health relevance of the project relates to developing new ways to either limit or enhance the immune response in the face of autoimmunity, immunosuppression or immunological diseases. ..
  3. Intermediary Metabolism, Histone Acetylation, and Transcriptional Regulation
    Ales Vancura; Fiscal Year: 2013
    ..pathway, and subsequently histone acetylation, are significantly reduced in cells with mutation of phospholipase C (PLC1)...
  4. Modification of Vascular Signaling in the Brain by ROS
    DAVID RAE HARDER; Fiscal Year: 2013
    ..We hope Dr. Daniel;Beard has agreed to act as our consultant and use data obtained in this project to guide future basic and clinical investigations into models of cerebral blood flow regulation. ..
  5. Role of Phospholipase C in Transcriptional Regulation
    Ales Vancura; Fiscal Year: 2009
    ..1999), cells with deletion of PLC1 gene (plc1) are completely devoid of all InsPs and the budding yeast thus represents an ideal system in which to ..
  6. PHOSPHOLIPASE C AND KINETOCHORE FUNCTION
    Ales Vancura; Fiscal Year: 2001
    ..2000) demonstrate that PLC in Saccharomyces cerevisiae (Plc1p protein encoded by the PLC1 gene) associates with kinetochores and affects their ability to bind microtubules...
  7. Role of the Oxidative Stress Pathway in Drug Resistance
    Randy Strich; Fiscal Year: 2007
    ..This destruction requires the conserved signaling molecule phosphatidylinositol-specific phospholipase C (PLC1)...
  8. Role of Inositol Polyphosphates in Kinetochore Function and Transcription
    Ales Vancura; Fiscal Year: 2006
    ..Since Plc1p (encoded by PLC1 gene) is the only PLC enzyme in the budding yeast Saccharomyces cerevisiae and hydrolysis of Ptdlns(4,5)P2 is the ..
  9. CELL BIOLOGY OF IMMUNE INTERACTIONS
    Abraham Kupfer; Fiscal Year: 1999
    ..that are implicated in regulating T cell responses (talin, PKCtheta, P-Tyr, grb2, lck, fyn, zap-70, PI-3K, PLCgamma1, and ras-GAP) in Ag-induced T-APC conjugates in order to determine their functional involvement in physiological ..
  10. REGULATION OF INTESTINAL EPITHELIAL CELL MIGRATION
    D Polk; Fiscal Year: 2005
    ..of EGF receptor regulation of intestinal epithelial cell migration? 2) What are the roles of phosphatidylinositol phospholipase C (PLC) gamma 1, protein kinase (PK) C epsilon, and other signal transduction molecules in EGF ..
  11. RELATIONSHIP OF KERATINOCYTE FUNCTION TO DIFFERENTIATION
    Daniel Bikle; Fiscal Year: 2007
    ..This proposal, then, represents a continuation of our ongoing successful effort at building a cohesive, interdisciplinary group aimed at unraveling the regulation of keratinocyte/epidermal differentiation. ..
  12. SIGNAL TRANSDUCTION FROM THE T CELL ANTIGEN RECEPTOR
    Robert Abraham; Fiscal Year: 2003
    ..However, experiments in fibroblasts stimulated with PDGF indicate that phosphorylation at residue 783 is necessary for increased enzymatic activity, while phosphorylation at Y771 results in inhibition of activity. ..
  13. REGULATION OF FC GAMMA RECEPTOR SIGNALING BY CD81
    Tony Fleming; Fiscal Year: 2000
    ..of the same non-receptor tyrosine kinases (NRTK) (syk), and phosphorylation of common downstream substrates (PLCgamma1,cbl, shc)...
  14. REGULATION OF BRANCHING MORPHOGENESIS OF SALIVARY GLAND
    EDWARD GRESIK; Fiscal Year: 2005
    ..The best characterized pathways signal via the RAS/MEK/ERK cascade, or phospholipase Cgamma1 (PLCgamma1), or phosphoinositol-3-kinase (PI3K). The latter two enzymes activate protein kinase C (PKC)...
  15. HYPERTONIC SALINE AND IMMUNE FUNCTION
    Wolfgang Junger; Fiscal Year: 2000
    ..p38 and JNKs) and the upstream signaling events including protein tyrosine kinases (PTKs), phospholipase Cg1 (PLCgamma1), protein kinase C (PKC)...
  16. PAF-STIMULATED PHOSPHOINOSITIDE TURNOVER IN PLATELETS
    SHIVENDRA SHUKLA; Fiscal Year: 1993
    ..The project will provide novel insight(s) in PAF-stimulated PPI turnover and on the importance of PI-anchored proteins in platelets...
  17. Characterization of ISG15-Modified PLC {gamma} 1
    Chinh Dao; Fiscal Year: 2005
    ....
  18. Trophic factor-mediated signaling in learning and memory
    Sonja Blum; Fiscal Year: 2005
    ..project is to investigate the roles of immediate intracellular transducers of trophic factor signaling, Grb2 and PLCgamma1, in hippocampus-dependent learning and memory, and to investigate whether they contribute to learning induced ..
  19. Phosphoinositide 3-Kinase Function in Lymphocytes
    David Fruman; Fiscal Year: 2006
    ..Aim 3 is to determine whether p85beta is required for activation of Itk, PLCgamma1, and sustained Ca2+ flux in T cells. Biochemical assays will be used to analyze signaling in purified T cells...
  20. Thrombin-Stimulated Intrauterine Signaling Pathway
    Mark Phillippe; Fiscal Year: 2007
    ..These studies are anticipated to significantly improve our understanding of the mechanisms underlying preterm labor in the presence of intrauterine infection. ..
  21. PI/PLC FUNCTION IN PREGNANT RAT MYOMETRIUM
    Mark Phillippe; Fiscal Year: 2002
    ..s. ..
  22. Molecular Mechanisms of Ectopic Bone Formation
    STEVEN LIETMAN; Fiscal Year: 2006
    ..abstract_text> ..
  23. Plcg1 integration of Vegf receptor signaling
    JACQUES VILLEFRANC; Fiscal Year: 2008
    ..abstract_text> ..
  24. The role of PIKE-S in mediating EGFR mitogenic signaling in OSCC cells
    Zhongjian Xie; Fiscal Year: 2008
    ..Understanding these mechanisms will bring the possibility of new molecular targets for development novel therapeutic options for the control of oral squamous cell carcinoma. [unreadable] [unreadable] [unreadable]..
  25. Role of Plcg1 in Vegf signaling
    Nathan Lawson; Fiscal Year: 2009
    ..Since these signaling mechanisms are evolutionary conserved, the molecules we identify in this proposal represent possible targets for clinical manipulation of pathological blood vessel formation. ..
  26. Steven J Siegel; Fiscal Year: 2016
    ..Aim 2 will specifically address protein protein interactions among erbB4 and other PSD proteins. Aim 3, will further characterize the impact of erbB4 dysregulation on NMDAR signaling and explore possible mechanisms. ..
  27. Determine the Transcriptional Activity of Non-integrated HIV-1 DNA
    Yuntao Wu; Fiscal Year: 2008
    ..Additionally, non-integrated viral DNA could serve as clinical markers for disease progression in certain situation. [unreadable] [unreadable] [unreadable]..
  28. The Fourth International Leukocyte Signal Transduction Workshop: Clinical Implica
    Amnon Altman; Fiscal Year: 2007
    ..abstract_text> ..
  29. The Role of Merlin Phosphorylation on its Tumor Suppressive Activity
    Keqiang Ye; Fiscal Year: 2010
    ..abstract_text> ..
  30. INTEGRATION OF STRESS AND MITOGEN SIGNALING
    Jonathan Cooper; Fiscal Year: 2001
    ..4) To map the interactions between ERK and Msk using approaches such at the two-hybrid system. 5) To clone Mapkip108 using conventional techniques. ..
  31. Mechanisms of dynamin family GTPases
    Mark A Lemmon; Fiscal Year: 2010
    ..We will also investigate the structural basis for cardiolipin recognition. Together, these studies promise to provide valuable insight into the mechanisms of action of these important large GTPases. ..
  32. Role of Protein Ubiquitination in Angiogenesis
    Nader Rahimi; Fiscal Year: 2010
    ..Identification of molecules that inhibit the angiogenic signaling of VEGFR-2 will provide new avenues for development of better and more effective agents to combat angiogenesis-associated diseases. ..
  33. Olfactory neurons from bipolar patients
    Chang Gyu Hahn; Fiscal Year: 2006
    ..2) To identify therapeutically relevant changes in ICa homeostasis following lithium treatment. 3) To characterize ORN cultures from bipolar patients using odorant induced ICa responses. ..
  34. SPECIFICITY OF DOMAIN INTERACTIONS IN CELL SIGNALING
    Mark A Lemmon; Fiscal Year: 2010
    ..In parallel, we will map orthologous interactions in mammalian cells, establishing a new paradigm for PH domains that resembles the role of SH2, and SH3 domains. ..
  35. High Resolution Digital Camera for TEM.
    Bridget Wilson; Fiscal Year: 2006
    ..The new camera will ensure the continued productivity of NIH-funded electron microscopy-based research programs in cellular and molecular biology and neurosciences at the University of New Mexico. [unreadable] [unreadable]..
  36. role of ubiquitinin in cancer progression
    Jin Ming Yang; Fiscal Year: 2005
    ..abstract_text> ..
  37. PKC Theta--A Novel Drug Target in T Cell Leukemias
    Amnon Altman; Fiscal Year: 2003
    ..abstract_text> ..
  38. PKC theta in the Immune Synapse and T Cell Anergy
    Amnon Altman; Fiscal Year: 2003
    ..They offer the potential for developing novel therapeutic strategies, which may be useful for modulating CD28 costimulation in disease. ..
  39. Anti-angiogenic signaling molecules in retinal cells
    Nader Rahimi; Fiscal Year: 2004
    ..our long-term goal is to begin to apply the information obtained from this project to the design of strategies to regulate angiogenesis in clinical settings. ..
  40. PHOSPHORYLATION IN RENAL CELL INJURY
    Goutam Ghosh Choudhury; Fiscal Year: 2004
    ..These studies will identify important signaling mechanisms involved in glomerular pathology and help to establish effective therapeutic modalities for treatment of proliferative forms of GN. ..
  41. Regulation of Meiotic Arrest in Oocytes by G-Proteins
    LISA MEHLMANN; Fiscal Year: 2004
    ..Understanding how the oocyte cell cycle is regulated within the follicle may find applications to practical problems including assisted reproductive techniques, contraception, and infertility. ..
  42. Role of the JIP-1-p190RhoGEF Complex In Neuron Function
    WILLIAM ARTHUR; Fiscal Year: 2004
    ..Furthermore, the importance of the JIP-l-p190RhoGEF association in brain development and neuronal migration will be investigated by disrupting this complex in mutant mice . ..
  43. FUNCTION AND REGULATION OF VAV IN LYMPHOCYTE ACTIVATION
    Amnon Altman; Fiscal Year: 2005
    ....
  44. Identifying Vegf target genes during artery development
    Nathan Lawson; Fiscal Year: 2005
    ....
  45. Mechanisms of ErbB2/HER2/Neu Activation
    Mark Lemmon; Fiscal Year: 2006
    ..3. To determine which portions of erbB receptors are required for interactions that cause transmodulation. ..
  46. Adolescent Antidepressant Treatment and Drug Reward
    CARLOS BOLANOS; Fiscal Year: 2005
    ..Data obtained from these experiments will improve our understanding of how psychotropics drugs affect developing brain resulting in neural adaptations to influence behavior later in life, especially vulnerability to drugs of abuse. ..
  47. Drug Sensitivity of Calcium Modulators from Brain Tumor
    Jin Ming Yang; Fiscal Year: 2006
    ..Therefore, the overall goal of this proposal is to identify new drugs for the treatment of GBM. ..
  48. Protective Mechanism of an Anti-Inflammatory Herbal Mix
    Ali Banan; Fiscal Year: 2006
    ..abstract_text> ..
  49. Targeting Brain Macrophages by a novel lentiviral vector
    Yuntao Wu; Fiscal Year: 2006
    ..abstract_text> ..
  50. VEGFR-1 and VEGFR-2 in angiogenesis
    Nader Rahimi; Fiscal Year: 2006
    ..Once we determine the mechanism by which VEGF receptors are engaged it will be possible to attenuate the angiogenic signal transduction relay by developing targeted therapeutic interventions aimed at angiogenesis suppression ..
  51. EGF, Oxidants & Intestinal Barrier Integrity
    Ali Banan; Fiscal Year: 2006
    ..abstract_text> ..
  52. MYCOPLASMA INFECTIONS AND CHILDHOOD ASTHMA
    T Atkinson; Fiscal Year: 2002
    ..Finally, I plan to investigate the effects of infection in a mouse model of asthma, which will permit the use of deletional mutant strains in the investigation of pathogenic mechanisms. ..
  53. CDP-choline: Mechanisms in Cerebral Ischemia
    RAO ADIBHATLA; Fiscal Year: 2006
    ..Arachidonic acid activates neutral sphingomyelinase, resulting in membrane disintegration. PCCT activity was stimulated by exogenous CDP-choline. Aim 2 will be tested in gerbil transient forebrain ischemia. ..