PLAGL1

Summary

Gene Symbol: PLAGL1
Description: PLAG1 like zinc finger 1
Alias: LOT1, ZAC, ZAC1, zinc finger protein PLAGL1, PLAG-like 1, lost on transformation 1, pleiomorphic adenoma gene-like 1, tumor suppressor ZAC
Species: human

Top Publications

  1. ncbi Identification of a zinc-finger gene at 6q25: a chromosomal region implicated in development of many solid tumors
    A Abdollahi
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Oncogene 14:1973-9. 1997
  2. ncbi Identification of a gene containing zinc-finger motifs based on lost expression in malignantly transformed rat ovarian surface epithelial cells
    A Abdollahi
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Res 57:2029-34. 1997
  3. pmc Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain
    D Spengler
    Max Planck Institute of Psychiatry, Molecular Neurobiology, Munich, Germany
    EMBO J 16:2814-25. 1997
  4. pmc hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer
    A Varrault
    Centre National de la Recherche Scientifique, UPR 9023, 141 rue de la Cardonille, F 34094 Montpellier Cedex 5, France
    Proc Natl Acad Sci U S A 95:8835-40. 1998
  5. ncbi Transcriptional activation capacity of the novel PLAG family of zinc finger proteins
    K Kas
    Laboratory for Molecular Oncology, Center for Human Genetics, University of Leuven and Flanders Interuniversity Institute for Biotechnology, Herestraat 49, B 3000 Leuven, Belgium
    J Biol Chem 273:23026-32. 1998
  6. ncbi Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1
    S M Huang
    Department of Pathology, University of Southern California, Los Angeles, California, CA 90089, USA
    Oncogene 20:2134-43. 2001
  7. ncbi A conserved imprinting control region at the HYMAI/ZAC domain is implicated in transient neonatal diabetes mellitus
    T Arima
    Wellcome CRC Institute of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QR, UK
    Hum Mol Genet 10:1475-83. 2001
  8. pmc Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDM
    Dan Ma
    Developmental Genetics Programme, The Babraham Institute, Cambridge, United Kingdom
    J Clin Invest 114:339-48. 2004
  9. ncbi Altered expression and loss of heterozygosity of the LOT1 gene in ovarian cancer
    Dusica Cvetkovic
    Ovarian Cancer Program, Department of Medical Oncology, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA, USA
    Gynecol Oncol 95:449-55. 2004
  10. pmc ZAC, LIT1 (KCNQ1OT1) and p57KIP2 (CDKN1C) are in an imprinted gene network that may play a role in Beckwith-Wiedemann syndrome
    Takahiro Arima
    Department of Reproductive Physiology and Endocrinology, Medical Institute of Bioregulation, Kyusyu University 4546, Tsurumihara, Beppu, Oita 874 0838, Japan
    Nucleic Acids Res 33:2650-60. 2005

Research Grants

  1. Masahiro Iwamoto; Fiscal Year: 2016
  2. Ethanol Modulation of Zinc-Activated Channels
    PAUL ANDREW DAVIES; Fiscal Year: 2010
  3. Hyperphosphorylated tau as drug target
    Min Hao Kuo; Fiscal Year: 2012
  4. Ca Handling & Arrhythmias Associated with LQT Syndrome
    KENNETH LAURITA; Fiscal Year: 2005
  5. MOLECULAR GENETICS OF OVARIAN SURFACE NEOPLASIA
    Thomas Hamilton; Fiscal Year: 2003
  6. Zinc Finger Protein Zac1 and Chondrogenesis
    Mon Li Chu; Fiscal Year: 2004

Patents

  1. T cell activating gene

Scientific Experts

Detail Information

Publications145 found, 100 shown here

  1. ncbi Identification of a zinc-finger gene at 6q25: a chromosomal region implicated in development of many solid tumors
    A Abdollahi
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Oncogene 14:1973-9. 1997
    ..Hence, we refer to this gene as Lot-1 (Lost on transformation 1, GenBank accession no. U72620)...
  2. ncbi Identification of a gene containing zinc-finger motifs based on lost expression in malignantly transformed rat ovarian surface epithelial cells
    A Abdollahi
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Res 57:2029-34. 1997
    ..Hence, we refer to this gene as Lot1 (lost on transformation 1; GenBank accession no. U72620). The most abundant transcript of the gene is approximately 6 kb...
  3. pmc Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain
    D Spengler
    Max Planck Institute of Psychiatry, Molecular Neurobiology, Munich, Germany
    EMBO J 16:2814-25. 1997
    ..cloning of a novel zinc finger protein which regulates apoptosis and cell cycle arrest and was accordingly named Zac1. In vitro Zac1 inhibited proliferation of tumor cells, as evidenced by measuring colony formation, growth rate and ..
  4. pmc hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer
    A Varrault
    Centre National de la Recherche Scientifique, UPR 9023, 141 rue de la Cardonille, F 34094 Montpellier Cedex 5, France
    Proc Natl Acad Sci U S A 95:8835-40. 1998
    ..C., Tagushi, T., Testa, J. R. & Hamilton, T. C. (1997) Cancer Res. 57, 2029-2034] recently isolated ZAC through its loss of expression in a surface epithelial ovary tumor model and accordingly named it Lot for "lost on ..
  5. ncbi Transcriptional activation capacity of the novel PLAG family of zinc finger proteins
    K Kas
    Laboratory for Molecular Oncology, Center for Human Genetics, University of Leuven and Flanders Interuniversity Institute for Biotechnology, Herestraat 49, B 3000 Leuven, Belgium
    J Biol Chem 273:23026-32. 1998
    ..PLAG1 and the two new PLAG1 family members (PLAGL1 and PLAGL2) constitute a novel subfamily of zinc finger proteins that recognize DNA and/or RNA...
  6. ncbi Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1
    S M Huang
    Department of Pathology, University of Southern California, Los Angeles, California, CA 90089, USA
    Oncogene 20:2134-43. 2001
    A recently discovered potential tumor suppressor protein, Zac1, was previously shown to promote cell cycle arrest and apoptosis, and to act as a positive or negative transcriptional cofactor for nuclear receptors...
  7. ncbi A conserved imprinting control region at the HYMAI/ZAC domain is implicated in transient neonatal diabetes mellitus
    T Arima
    Wellcome CRC Institute of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QR, UK
    Hum Mol Genet 10:1475-83. 2001
    ..exhibit paternal uniparental disomy (UPD) of chromosome 6q24, where at least two imprinted genes, HYMAI and ZAC, have so far been characterized...
  8. pmc Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDM
    Dan Ma
    Developmental Genetics Programme, The Babraham Institute, Cambridge, United Kingdom
    J Clin Invest 114:339-48. 2004
    ..pattern of this imprinted disorder implicates overexpression of one or both genes within the TNDM locus: ZAC, which encodes a proapoptotic zinc finger protein, and HYMAI, which encodes an untranslated mRNA...
  9. ncbi Altered expression and loss of heterozygosity of the LOT1 gene in ovarian cancer
    Dusica Cvetkovic
    Ovarian Cancer Program, Department of Medical Oncology, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA, USA
    Gynecol Oncol 95:449-55. 2004
    Previously, we demonstrated that the LOT1 (PLAGL1/ZAC1) gene encodes a zinc-finger transcription factor and has growth suppressive effects in carcinoma cell lines...
  10. pmc ZAC, LIT1 (KCNQ1OT1) and p57KIP2 (CDKN1C) are in an imprinted gene network that may play a role in Beckwith-Wiedemann syndrome
    Takahiro Arima
    Department of Reproductive Physiology and Endocrinology, Medical Institute of Bioregulation, Kyusyu University 4546, Tsurumihara, Beppu, Oita 874 0838, Japan
    Nucleic Acids Res 33:2650-60. 2005
    ..Patients with these diseases share many characteristics. Here we show that mouse Zac1 and p57Kip2 have a strikingly similar expression pattern...
  11. ncbi The candidate tumor suppressor gene ZAC is involved in keratinocyte differentiation and its expression is lost in basal cell carcinomas
    Eugenia Basyuk
    Institut de Genomique Fonctionnelle, 141, rue de la Cardonille, F 34094 Montpellier Cedex 5, France
    Mol Cancer Res 3:483-92. 2005
    b>ZAC is a zinc finger transcription factor that induces apoptosis and cell cycle arrest in various cell lines...
  12. ncbi Frequent loss of heterozygosity at 6q in pheochromocytoma
    Sebsebe Lemeta
    Department of Pathology, University of Helsinki and HUSLAB, Helsinki, Finland
    Hum Pathol 37:749-54. 2006
    ..We further focused the search using markers specific for the ZAC1 gene region located at 6q24-25...
  13. ncbi LOT1 (ZAC1/PLAGL1) and its family members: mechanisms and functions
    Abbas Abdollahi
    Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    J Cell Physiol 210:16-25. 2007
    Lost-on-transformation 1 (LOT1) (PLAGL1/ZAC1) is a member of the novel subfamily of zinc-finger transcription factors, designated as PLAG family...
  14. ncbi Zac1 regulates an imprinted gene network critically involved in the control of embryonic growth
    Annie Varrault
    Institut de Genomique Fonctionnelle, CNRS UMR5203, INSERM U661, Universite Montpellier 1, Universite Montpellier 2, Montpellier, F 34094, France
    Dev Cell 11:711-22. 2006
    ..We show that inactivation of the maternally repressed Zac1 transcription factor results in intrauterine growth restriction, altered bone formation, and neonatal lethality...
  15. ncbi Tissue-specific imprinting of the ZAC/PLAGL1 tumour suppressor gene results from variable utilization of monoallelic and biallelic promoters
    Elizabeth M Valleley
    Section of Genetics, Leeds Institute of Molecular Medicine, University of Leeds, St James s University Hospital, Leeds LS9 7TF, UK
    Hum Mol Genet 16:972-81. 2007
    The tumour suppressor gene ZAC/PLAGL1 is widely expressed in many human tissues during fetal development and throughout life...
  16. ncbi Preferential loss of the nonimprinted allele for the ZAC1 tumor suppressor gene in human capillary hemangioblastoma
    Sebsebe Lemeta
    Biological Mechanisms and Prevention of Work related Diseases, Finnish Institute of Occupational Health, Helsinki, Finland
    J Neuropathol Exp Neurol 66:860-7. 2007
    ..We previously identified a minimal deleted area at 6q23-24 in CHB, and the present study focused on the ZAC1 gene (6q24-25). ZAC1 is a maternally imprinted tumor suppressor gene with antiproliferative properties...
  17. pmc Hypomethylation at multiple maternally methylated imprinted regions including PLAGL1 and GNAS loci in Beckwith-Wiedemann syndrome
    Jet Bliek
    Department of Clinical Genetics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Eur J Hum Genet 17:611-9. 2009
    ..Some ICRs, including the PLAGL1 and GNAS/NESPAS ICRs implicated in the aetiology of transient neonatal diabetes and pseudohypoparathyroidism type ..
  18. doi Tumor ZAC1 expression is associated with the response to somatostatin analog therapy in patients with acromegaly
    Marily Theodoropoulou
    Department of Endocrinology, Max Planck Institute of Psychiatry, 80804 Munich, Germany
    Int J Cancer 125:2122-6. 2009
    ..We have found that the tumor suppressor ZAC1 (LOT1/PLAGL1) is essential for the antiproliferative effect of SSA in pituitary tumor cells...
  19. doi ZAC1 target genes and pituitary tumorigenesis
    Marily Theodoropoulou
    Max Planck Institute of Psychiatry, Department of Endocrinology, Kraepelinstrasse 10, 80804 Munich, Germany
    Mol Cell Endocrinol 326:60-5. 2010
    The zinc-finger protein Zac1 has a role as transcription factor and coregulator and plays an important role in pituitary development, maturation and tumorigenesis. Zac1 target genes control cell proliferation and hormone synthesis...
  20. doi Loss of expression of ZAC/PLAGL1 in diffuse large B-cell lymphoma is independent of promoter hypermethylation
    Elizabeth M A Valleley
    Section of Genetics, Leeds Institute of Molecular Medicine, University of Leeds, St James s University Hospital, Leeds, UK
    Genes Chromosomes Cancer 49:480-6. 2010
    ZAC/PLAGL1 is a ubiquitously expressed, imprinted tumor suppressor gene located on 6q24, a chromosomal region that is frequently deleted in diffuse large B-cell lymphoma (DLBCL)...
  21. doi Somatostatin analogs modulate AIP in somatotroph adenomas: the role of the ZAC1 pathway
    Harvinder S Chahal
    Centre for Endocrinology, Barts and the London School of Medicine, Queen Mary University of London, London EC1M 6BQ, United Kingdom
    J Clin Endocrinol Metab 97:E1411-20. 2012
    ..Somatotroph adenomas harboring aryl hydrocarbon receptor interacting protein (AIP) mutations respond less well to somatostatin analogs, suggesting that the effects of somatostatin analogs may be mediated by AIP...
  22. ncbi The cell cycle control gene ZAC/PLAGL1 is imprinted--a strong candidate gene for transient neonatal diabetes
    M Kamiya
    CREST, Japan Science and Technology Corporation JST, Genome Exploration Research Group, Genomic Sciences Center GSC, Genome Science Laboratory and Biogenetic Research Center, RIKEN Tsukuba Life Science Center, Ibaraki, Japan
    Hum Mol Genet 9:453-60. 2000
    ..and the identification in this way of ZAC (zinc finger protein which regulates apoptosis and cell cycle arrest)/ PLAGL1 (pleomorphicadenoma of the salivary gland gene like 1) as a strong candidate gene for transient neonatal diabetes ..
  23. doi Epigenetics, genomic imprinting and assisted reproductive technology
    Y Le Bouc
    Explorations Fonctionnelles Endocriniennes, Hopital d Enfants Armand Trousseau, AP HP, 75571 Paris, France
    Ann Endocrinol (Paris) 71:237-8. 2010
    ..and IGF2 DMRs, KCNQ1OT1 [ICR2], SNRPN [chromosome 15 q11-13], PEG/MEST1 [chromosome 7q31], IGF type2 receptor and ZAC1 [chromosome 6q26 et 6q24 respectively], DLK1/GTL2-IG-DMR [chromosome 14q32] and GNAS locus [chromosome 20q13.3])...
  24. pmc Zac1 functions through TGFbetaII to negatively regulate cell number in the developing retina
    Lin Ma
    IMCH, HBI, University of Calgary, T2N 4N1, Canada
    Neural Dev 2:11. 2007
    ..Here we report a similar role for two tumor suppressor genes, the Zac1 zinc finger transcription factor and that encoding the cytokine TGFbetaII, in the developing retina.
  25. ncbi Promiscuous and specific phospholipid binding by domains in ZAC, a membrane-associated Arabidopsis protein with an ARF GAP zinc finger and a C2 domain
    R B Jensen
    Institute of Molecular Biology, University of Copenhagen, Denmark
    Plant Mol Biol 44:799-814. 2000
    ..One of these is a 37 kDa protein, designated ZAC, which has a novel domain structure in which the N-terminal ARF GAP domain and a C-terminal C2 domain are separated ..
  26. pmc Characterization of a novel protective monoclonal antibody that recognizes an epitope common to Vibrio cholerae Ogawa and Inaba serotypes
    Madushini N Dharmasena
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, USA
    Microbiology 155:2353-64. 2009
    ..The cDNA-derived amino acid sequence of mAb 72.1 is closely related to the previously characterized mAb ZAC-3, which is thought to recognize an epitope in the lipid A core region of O1 LPS...
  27. pmc High-throughput analysis of candidate imprinted genes and allele-specific gene expression in the human term placenta
    Caroline Daelemans
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1 SA, UK
    BMC Genet 11:25. 2010
    ..Using two allele-specific high-throughput technologies alongside bioinformatics predictions, normal term human placenta was screened to find new imprinted genes and to ascertain the extent of ASE in this tissue...
  28. ncbi Aberrant DNA methylation of imprinted loci in superovulated oocytes
    A Sato
    St Luke Clinic, Tsumori, Oita, Japan
    Hum Reprod 22:26-35. 2007
    ..The most likely candidate for the gametic mark is DNA methylation. However, the timing of DNA methylation acquisition in adult oocytogenesis and the effects of superovulation are unknown...
  29. pmc Transcriptome analysis identifies pathways associated with enhanced maternal performance in QSi5 mice
    Palaniappan Ramanathan
    Centre for Advanced Technologies in Animal Genetics and Reproduction, Faculty of Veterinary Science, University of Sydney, NSW 2006, Australia
    BMC Genomics 9:197. 2008
    ..The QSi5 inbred strain of mice was selected for high fecundity and low inter-litter interval, and is very successful at weaning large numbers of offspring when compared to other inbred strains...
  30. doi Gene expression profile of primary prostate epithelial and stromal cells in response to sulforaphane or iberin exposure
    Karen F Chambers
    Natural Products and Health Programme, Institute of Food Research, Norwich, UK
    Prostate 69:1411-21. 2009
    ..While there are many studies regarding the biological activity of SF, mainly undertaken with cancerous cells, there are few studies associated with IB...
  31. doi A phylogenetic approach to test for evidence of parental conflict or gene duplications associated with protein-encoding imprinted orthologous genes in placental mammals
    Mary J O'Connell
    Genetics and Biotechnology Lab, Department of Biochemistry and Biosciences Institute, University College Cork UCC, Lee Maltings 2 10, Cork, Ireland
    Mamm Genome 21:486-98. 2010
    ..selection for 14 imprinted genes where it is known that the gene is imprinted in a specific lineage, namely for: PLAGL1, IGF2, SLC22A18, OSBPL5, DCN, DLK1, RASGRF1, IGF2R, IMPACT, GRB10, NAPIL4, UBE3A, GATM and GABRG3...
  32. pmc Detection of differentially expressed genes between Erhualian and Large White placentas on day 75 and 90 of gestation
    Quan Yong Zhou
    Key Laboratory of Agricultural Animal Genetics, Breeding, and Reproduction of Ministry of Education and Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture, Huazhong Agricultural University, Wuhan, 430070, PR China
    BMC Genomics 10:337. 2009
    ..Two female placentas from one sow were used to extract RNA and then pooled in equal volumes. Twelve pooled samples were hybridized to the porcine Affymetrix GeneChip...
  33. pmc An imprinted gene network that controls mammalian somatic growth is down-regulated during postnatal growth deceleration in multiple organs
    Julian C Lui
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
    Am J Physiol Regul Integr Comp Physiol 295:R189-96. 2008
    ..For these genes, Igf2, H19, Plagl1, Mest, Peg3, Dlk1, Gtl2, Grb10, Ndn, Cdkn1c, and SLC38a4, the declines show a temporal pattern similar to the ..
  34. doi Pharmacokinetic interaction between ϵ-acetamidocaproic acid (AACA) and cimetidine in indomethacin-induced acute gastric ulcer and control rats: inhibition of active renal secretion of AACA by cimetidine
    Y H Choi
    College of Pharmacy, Dongguk University Seoul, Seoul, South Korea
    Xenobiotica 41:409-15. 2011
    After both the intravenous and oral administration of zinc acexamate [ZAC; ion-pairing between zinc and ϵ-acetamidocaproic acid (AACA)] and cimetidine together, the areas under the curve (AUCs) of AACA were significantly greater [by 28...
  35. pmc Zac1 (Lot1), a potential tumor suppressor gene, and the gene for epsilon-sarcoglycan are maternally imprinted genes: identification by a subtractive screen of novel uniparental fibroblast lines
    G Piras
    Cancer and Developmental Biology Laboratory, ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
    Mol Cell Biol 20:3308-15. 2000
    ..Here we show that the epsilon-sarcoglycan gene (Sgce) and Zac1 (Lot1) are both paternally expressed imprinted genes...
  36. ncbi Imprinted status of pleomorphic adenoma gene-like I and paternal expression gene 10 genes in pigs
    F W Zhang
    Key Laboratory of Agricultural Animal Genetics, Breeding, and Reproduction, Ministry of Education, Huazhong Agricultural University, Wuhan 430070, China
    J Anim Sci 85:886-90. 2007
    ..approach was used to detect the expression patterns of the porcine pleomorphic adenoma gene-like I (PLAGL1) and paternal expression gene 10 (PEG10) genes...
  37. pmc Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse
    Julie A Williams
    Department of Orthopaedic Surgery, Thomas Jefferson University College of Medicine, Philadelphia, PA 19107, USA
    Dev Biol 328:315-27. 2009
    ..in chondrocytes under retinoid-free culture conditions; production is further boosted by co-repressor Zac1 or pharmacologic agents that enhance RAR repressor function; and RAR/Zac1 function on aggrecan expression may ..
  38. doi Molecularly genetic analysis of von Hippel-Lindau associated central nervous system hemangioblastoma
    Jing Zhou
    Department of Pathology, Nanjing Jinling Hospital, Clinical School of Medical College of Nanjing University, Nanjing, Jiangsu, China
    Pathol Int 60:452-8. 2010
    ..In addition, expression of the ZAC1 tumor suppressor gene protein was studied using immunohistochemistry staining in CHB tissues with a specific ..
  39. pmc Heterogeneous and complex rearrangements of chromosome arm 6q in chondromyxoid fibroma: delineation of breakpoints and analysis of candidate target genes
    Salvatore Romeo
    Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Pathol 177:1365-76. 2010
    ..Two known tumor suppressor genes map to the latter region: PLAGL1 and UTRN. However, neither of these two genes nor BCLAF1 and COL12A1, respectively located in 6q23...
  40. doi Isolation of substances with antiproliferative and apoptosis-inducing activities against leukemia cells from the leaves of Zanthoxylum ailanthoides Sieb. & Zucc
    Su Tze Chou
    Department of Food and Nutrition, Providence University, Taichung, Taiwan, ROC
    Phytomedicine 18:344-8. 2011
    ..The chloroform-soluble fraction (ZAC) of the crude extract of this plant showed cytotoxic activity against human promyelocytic leukemia (HL-60) and ..
  41. ncbi The tumorigenic diversity of the three PLAG family members is associated with different DNA binding capacities
    Karen Hensen
    Laboratory for Molecular Oncology, Center for Human Genetics, University of Leuven KUL and Flanders Interuniversity Institute for Biotechnology VIB, Herestraat 49 B 3000 Leuven, Belgium
    Cancer Res 62:1510-7. 2002
    ..of zinc finger proteins comprising the tumor suppressor candidate PLAG-like1 (also called ZAC1 or lost on transformation 1) and PLAGL2...
  42. doi Investigation of 90 patients referred for molecular cytogenetic analysis using aCGH uncovers previously unsuspected anomalies of imprinting
    Rebecca L Poole
    Division of Human Genetics, University of Southampton School of Medicine, Southampton SO16 6YD, UK
    Am J Med Genet A 152:1990-3. 2010
    ..Methylation analysis was performed at 13 imprinted loci [PLAGL1, IGF2R, MEST, GRB10, H19, IGF2 DMR2 (IGF2P0), KCNQ1OT1 (KvDMR), MEG3, SNRPN, PEG3, GNAS (GNAS exon 1a and NESP55) ..
  43. doi Haploinsufficiency of the murine polycomb gene Suz12 results in diverse malformations of the brain and neural tube
    Xavier Miro
    Max Planck Institute of Biophysical Chemistry, Department of Molecular Cell Biology, Gottingen D 37077, Germany
    Dis Model Mech 2:412-8. 2009
    ..Here, we show that a pathway that involves Zac1 (also known as Plagl1 or Lot1) and controls neuronal proliferation is altered in mice that are heterozygous for the polycomb gene Suz12, ..
  44. ncbi DNA demethylation reactivates a subset of imprinted genes in uniparental mouse embryonic fibroblasts
    A El Kharroubi
    Cancer and Developmental Biology Laboratory, Division of Basic Sciences, NCI FCRDC, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 276:8674-80. 2001
    ..of imprinted genes including H19 (H19 fetal liver mRNA), p57(Kip2), Peg3/Pw1 (paternally expressed gene 3), and Zac1 (zinc finger-binding protein regulating apoptosis and cell cycle arrest)...
  45. pmc Pancreatic islet expression profiling in diabetes-prone C57BLKS/J mice reveals transcriptional differences contributed by DBA loci, including Plagl1 and Nnt
    Abraham A Anderson
    Department of Computational Biology, Amgen Inc, One Amgen Center Dr, Thousand Oaks, CA 91320, USA
    Pathogenetics 2:1. 2009
    ..Furthermore, DBA2/J (DBA) mice are also susceptible to beta-cell failure and share 25% of their genome with BLKS; thus the DBA genome may contribute to beta-cell dysfunction in BLKS mice...
  46. ncbi The mouse Zac1 locus: basis for imprinting and comparison with human ZAC
    Rachel J Smith
    Developmental Genetics Programme, The Babraham Institute, Cambridge CB2 4AT, UK
    Gene 292:101-12. 2002
    ..10 in a screen for imprinted genes. The homologous human gene ZAC (also known as LOT1 and PLAGLI) is a candidate gene for transient neonatal diabetes (TNDM), an imprinted disorder associated with ..
  47. ncbi Cyclic AMP-mediated regulation of transcription factor Lot1 expression in cerebellar granule cells
    Andrea Contestabile
    Department of Human and General Physiology, University of Bologna, 40126 Bologna, Italy
    J Biol Chem 280:33541-51. 2005
    b>Lot1, a zinc finger transcription factor acting as a tumor suppressor gene on tumoral cells, is highly expressed during brain development...
  48. pmc Regulation of cardiomyocyte Glut4 expression by ZAC1
    Michael P Czubryt
    Department of Physiology, University of Manitoba, Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre, Winnipeg, Manitoba R2H 2A6, Canada
    J Biol Chem 285:16942-50. 2010
    The transcription factor ZAC1 is expressed in a variety of tissues including the developing heart, but its physiological role is unclear...
  49. pmc Importin alpha1 is involved in the nuclear localization of Zac1 and the induction of p21WAF1/CIP1 by Zac1
    Shih Ming Huang
    Department of Biochemistry and Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan 114, Republic of China
    Biochem J 402:359-66. 2007
    b>Zac1, a novel seven-zinc-finger transcription factor, preferentially binds GC-rich DNA elements and has intrinsic transactivation activity. To date, the NLS (nuclear localization signal) of Zac1 has not been empirically determined...
  50. pmc Promoter hypermethylation of CDH1, FHIT, MTAP and PLAGL1 in gastric adenocarcinoma in individuals from Northern Brazil
    Mariana Ferreira Leal
    Genetics Division, Department of Morphology, Federal University of Sao Paulo, Sao Paulo, SP, Brazil
    World J Gastroenterol 13:2568-74. 2007
    To evaluate the methylation status of CDH1, FHIT, MTAP and PLAGL1 promoters and the association of these findings with clinico-pathological characteristics.
  51. ncbi Characterization of the methylation-sensitive promoter of the imprinted ZAC gene supports its role in transient neonatal diabetes mellitus
    A Varrault
    UPR 9023 CNRS Centre CNRS INSERM de Pharmacologie Endocrinologie 141, rue de la Cardonille, 34094 Montpellier Cedex 05, France
    J Biol Chem 276:18653-6. 2001
    b>ZAC is a recently isolated zinc finger protein that induces apoptosis and cell cycle arrest...
  52. ncbi A positive feedback mechanism in the transcriptional activation of Apaf-1 by p53 and the coactivator Zac-1
    Galit Rozenfeld-Granot
    Department of Pediatric Hemato Oncology, The Chaim Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Israel
    Oncogene 21:1469-76. 2002
    ..p53 activation of the Apaf-1 luciferase construct can be enhanced by the putative tumor suppressor gene product, Zac-1, a transcription factor that has previously been shown to inhibit cell proliferation...
  53. ncbi Identification of epidermal growth factor-responsive genes in normal rat ovarian surface epithelial cells
    Abbas Abdollahi
    Ovarian Cancer Program, Department of Medical Oncology, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111 2497, USA
    Biochem Biophys Res Commun 307:188-97. 2003
    ..of downstream effectors of the EGFR pathway, as exemplified by aberrant expression of p66Shc, c-Jun, c-Myc, c-Fos, Lot1, p21Cip/Waf, and cdc25A...
  54. ncbi Alterations in cell cycle genes in early stage lung adenocarcinoma identified by expression profiling
    Sunil Singhal
    Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cancer Biol Ther 2:291-8. 2003
    ..e., cdc2, cullin 4A, ZAC, p57, DP-1, GADD45, PISSLRE, cdc20) nor in any other tumors (i.e., cyclin F, cullin 5, p34)...
  55. ncbi Loss of expression of ZAC/LOT1 in squamous cell carcinomas of head and neck
    Susanne Koy
    Department of Oral and Maxillofacial Surgery, University Hospital Carl Gustav Carus, Technical University Dresden, Fetscherst 74, 01307 Dresden, Germany
    Head Neck 26:338-44. 2004
    ZAC/Lot1 is a previously identified candidate tumor suppressor gene. The gene maps to the human chromosome 6q24-q25, a region frequently deleted in squamous cell carcinomas of the head and neck and other solid tumors.
  56. ncbi Epigenetic silencing of the imprinted gene ZAC by DNA methylation is an early event in the progression of human ovarian cancer
    Tetsuya Kamikihara
    Department of Molecular Genetics, Division of Molecular and Cell Therapeutics, Medical Institute of Bioregulation, Kyusyu University, Oita, Japan
    Int J Cancer 115:690-700. 2005
    b>ZAC is a paternally expressed, imprinted gene located on chromosome 6q24, within a region known to harbor a tumor suppressor gene for several types of neoplasia, including human ovarian cancer (HOC)...
  57. ncbi Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray
    Satoshi Yamashita
    Carcinogenesis Division, National Cancer Center Research Institute, 1 1 Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Sci 97:64-71. 2006
    ..F2R, FADS1, FSD1, FST, FYN, GPR54, GREM1, IGFBP3, IGFBP7, IRS2, KISS1, MARK1, MLF1, MSX1, MTSS1, NT5E, PAX6, PLAGL1, PLAU, PPIC, RBP4, RORA, SCRN1, TBX3, TFAP2C, TNFSF9, ULBP2, WIF1, ZNF177 and ZNF559) were methylated in at least ..
  58. ncbi PLAG1, the prototype of the PLAG gene family: versatility in tumour development (review)
    Frederik Van Dyck
    Laboratory for Molecular Oncology and Flanders Interuniversity Institute for Biotechnology, Department of Human Genetics, K U Leuven, B 3000 Leuven, Belgium
    Int J Oncol 30:765-74. 2007
    ..e. the PLAGL1 and PLAGL2 gene...
  59. ncbi Robo1 and robo2 control the development of the lateral olfactory tract
    Coralie Fouquet
    Centre National de la Recherche Scientifique and Université Pierre et Marie Curie Paris 6, Unite Mixte de Recherche 7102, Paris, 75005 France
    J Neurosci 27:3037-45. 2007
    ..Finally, the position of lot1-expressing cells, which have been proposed to be the LOT guidepost cells, appears unaffected in Slit1-/-;Slit2-/- ..
  60. doi Clinical characterisation of the multiple maternal hypomethylation syndrome in siblings
    Susanne E Boonen
    Genetic Counselling Clinic, Kennedy Center, Glostrup, Denmark
    Eur J Hum Genet 16:453-61. 2008
    ..DNA, we found a mosaic spectrum of hypomethylation at the following maternally methylated loci in both sibs: ZAC (6q24), KCNQ1OT1 (11p15.5), GRB10 (7p11.2-12), PEG3 (19q13), PEG1/MEST (7q32), and NESPAS (20q13)...
  61. doi Modulation of the cyclin-dependent kinase inhibitor p21(WAF1/Cip1) gene by Zac1 through the antagonistic regulators p53 and histone deacetylase 1 in HeLa Cells
    Pei Yao Liu
    Department of Biochemistry, National Defense Medical Center, Taipei 114, Taiwan, Republic of China
    Mol Cancer Res 6:1204-14. 2008
    b>Zac1 is a novel seven-zinc finger protein which possesses the ability to bind specifically to GC-rich DNA elements...
  62. doi Pharmacokinetics and first-pass effects of epsilon-acetamidocaproic acid after administration of zinc acexamate in rats
    Y H Choi
    College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Shinlim Dong, Kwanak gu, Seoul, South Korea
    Xenobiotica 40:485-98. 2010
    1. Zinc acexamate (ZAC) is ionized to zinc and epsilon-acetamidocaproic acid (AACA)...
  63. doi Viral induction of Zac1b through TLR3- and IRF3-dependent pathways
    Barbara Warzée
    Laboratory of Cellular and Molecular Physiology, GIGA Research, University of Liege, Liege, Belgium
    Mol Immunol 48:119-27. 2010
    Zinc finger protein regulator of apoptosis and cell cycle arrest (Zac1) is a transcription factor able to induce apoptosis or cell cycle arrest through independent pathways...
  64. doi Zac1, an Sp1-like protein, regulates human p21(WAF1/Cip1) gene expression in HeLa cells
    Pei Yao Liu
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 114, Taiwan, ROC
    Exp Cell Res 317:2925-37. 2011
    b>Zac1 functions as both a transcription factor and a transcriptional cofactor for p53, nuclear receptors (NRs) and NR coactivators. Zac1 might also act as a transcriptional repressor via the recruitment of histone deacetylase 1 (HDAC1)...
  65. doi Filamin C plays an essential role in the maintenance of the structural integrity of cardiac and skeletal muscles, revealed by the medaka mutant zacro
    Misato Fujita
    Department of Biological Information, Tokyo Institute of Technology, 4259 B 33 Nagatsuta, Yokohama 226 8501, Japan
    Dev Biol 361:79-89. 2012
    ..Here we report a medaka mutant, zacro (zac), that displayed an enlarged heart, caused by rupture of the myocardiac wall, and progressive skeletal muscle ..
  66. doi Down-regulation of the transcription factor ZAC1 upon pre- and postconditioning protects against I/R injury in the mouse myocardium
    Anne Vincent
    Institut de Genomique Fonctionnelle, F 34000 Montpellier, France
    Cardiovasc Res 94:351-8. 2012
    ..Ischaemic preconditioning (PreC) and postconditioning (PostC) reduce infarct size in animal models and human. Zac1 was identified as the only gene related to apoptosis and jointly down-regulated upon PreC and PostC...
  67. pmc A set of imprinted genes required for normal body growth also promotes growth of rhabdomyosarcoma cells
    Geoffrey Rezvani
    Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
    Pediatr Res 71:32-8. 2012
    ..this decline is due, in part, to decline in the expression of growth-promoting imprinted genes including Mest, Plagl1, Peg3, Dlk1, and Igf2...
  68. pmc Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elements
    Ying Liu
    School of Medicine, Duke University, Durham, NC, USA
    Epigenetics 7:735-46. 2012
    ..methylated regions (DMRs) regulating imprinted genes IGF2/H19, DLK1/MEG3, MEST, PEG3, PEG10/SGCE, NNAT and PLAGL1. Multiple regression models were used to examine the relationship between depressed mood, birth weight and DMR ..
  69. doi Gene network analyses of first service conception in Brangus heifers: use of genome and trait associations, hypothalamic-transcriptome information, and transcription factors
    M R S Fortes
    School of Veterinary Science, The University of Queensland, Gatton Campus, QLD 4343, Australia
    J Anim Sci 90:2894-906. 2012
    ..There were 5 transcription factors with 21 or more connections: ZMAT3, STAT6, RFX4, PLAGL1, and NR6A1 for FSC. The SNP that identified these genes were intragenic and were on chromosomes 1, 5, 9, and 11...
  70. pmc Mid-gestational gene expression profile in placenta and link to pregnancy complications
    Liis Uusküla
    Human Molecular Genetics Group, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia
    PLoS ONE 7:e49248. 2012
    ..05) mid-gestational peak of placental gene expression for BMP5, CCNG2, CDH11, FST, GATM, GPR183, ITGBL1, PLAGL1, SLC16A10 and STC1, followed by sharp decrease in mRNA levels at term (t-test, FDR P<0.05)...
  71. ncbi The influence of etiological factors in the occurence of diastema mediana
    Biljana Kapusevska
    Faculty of Dentistry, St Panteleimon P H O Dental Clinical Centre, Department of Prosthodontics, Ss Cyril and Methodius University, Skopje, R Macedonia
    Pril (Makedon Akad Nauk Umet Odd Med Nauki) 35:169-77. 2014
    ..or "lucky teeth" and is encountered even among world famous figures including Brigitte Bardot, Eliah Wood, Madonna, Zac Efron, Amy Winehouse and Elton John...
  72. pmc Gene co-expression network analysis provides novel insights into myostatin regulation at three different mouse developmental timepoints
    Xuerong Yang
    Animal Nutrition Institute, Sichuan Agricultural University, Ya an, Sichuan, China Department of Animal Science, Iowa State University, Ames, Iowa, United States of America
    PLoS ONE 10:e0117607. 2015
    ..transcription factor binding sites in differentially expressed genes included SMAD3, SP1, ZFP187, and PLAGL1. The use of regulatory (RIF) and phenotypic (PIF) impact factor and differential hubbing co-expression analyses ..
  73. pmc Germline and somatic imprinting in the nonhuman primate highlights species differences in oocyte methylation
    Clara Y Cheong
    Growth, Development and Metabolism Program, Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research A STAR, Singapore 117609
    Genome Res 25:611-23. 2015
    ..For example, like mouse and unlike human, macaque IGF2R is consistently imprinted, and the PLAGL1, INPP5F transcript variant 2, and PEG3 imprinting control regions are not methylated in the macaque germline but ..
  74. pmc Beckwith-Wiedemann syndrome prenatal diagnosis by methylation analysis in chorionic villi
    Leda Paganini
    a Division of Pathology Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico Department of Pathophysiology and Transplantation Università degli Studi di Milano Milano, Italy
    Epigenetics 10:643-9. 2015
    ..methylated regions (DMRs) at several imprinted loci (ICR1, ICR2, H19, PWS/AS-ICR, GNASXL, GNAS1A, ZAC/PLAGL1, and MEST) and at non-imprinted MGMT and RASSF1A promoters...
  75. doi Interplay between polymer chain conformation and nanoparticle assembly in model industrial silica/rubber nanocomposites
    Adrien Bouty
    Laboratoire Leon Brillouin, CEA Saclay, 91191 Gif sur Yvette Cedex, France and Manufacture Française des Pneumatiques MICHELIN, Site de Ladoux, 23 Place des Carmes Déchaux, F 63 040 Clermont Ferrand, Cedex 9, France
    Faraday Discuss 186:325-43. 2016
    ..We associated specific chain (d) labeling, and the so-called zero average contrast (ZAC) method, with SANS, in situ SANS and SAXS/TEM experiments to extract the polymer chain scattering signal at rest ..
  76. pmc Genome-wide DNA methylation analysis of transient neonatal diabetes type 1 patients with mutations in ZFP57
    Mads Bak
    Wilhelm Johannsen Center for Functional Genome Research, Institute of Cellular and Molecular Medicine, Panum Institute, University of Copenhagen, DK 2200, Copenhagen N, Denmark
    BMC Med Genet 17:29. 2016
    ..Transient neonatal diabetes mellitus 1 is caused by overexpression of the maternally imprinted genes PLAGL1 and HYMAI on chromosome 6q24...
  77. pmc A monoclonal antibody that targets the conserved core/lipid A region of lipopolysaccharide affects motility and reduces intestinal colonization of both classical and El Tor Vibrio cholerae biotypes
    Kara J Levinson
    Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, NY 12208, United States Department of Biomedical Sciences, University at Albany, Albany, NY 12208, United States
    Vaccine 34:5833-5836. 2016
    ..Here we report that ZAC-3, a monoclonal antibody against the core/lipid A region of V. cholerae LPS is a potent inhibitor of V...
  78. ncbi Gonadotropin-induced gene regulation in human granulosa cells obtained from IVF patients: modulation of genes coding for growth factors and their receptors and genes involved in cancer and other diseases
    E Rimon
    Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 64239, Israel
    Int J Oncol 24:1325-38. 2004
    ..Gene transcripts for oncogenes and tumor markers such as pleiomorphic adenoma gene-like 1 (Plagl1) tumor antigen (L6) and claudin 3 were markedly elevated following LH and FSH stimulation...
  79. ncbi Molecular analyses of the candidate tumor suppressor gene, PLAGL1, in benign and malignant salivary gland tumors
    Fredrik Enlund
    Lundberg Laboratory for Cancer Research, Department of Pathology, Goteborg University, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
    Eur J Oral Sci 112:545-7. 2004
    ..Here we have examined the possible involvement of the candidate tumor suppressor gene, PLAGL1, in these deletions and translocations...
  80. pmc Genomic imprinting is variably lost during reprogramming of mouse iPS cells
    Sachiko Takikawa
    Black Family Stem Cell Institute, Department of Developmental and Regenerative Biology, Graduate School of Biological Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, NY 10029, USA
    Stem Cell Res 11:861-73. 2013
    ..Intriguingly, one to several paternal chromosomes appeared to have acquired de novo methylation at the Snrpn and Zac1 imprinted regions in a high percentage of iPS clones...
  81. pmc DNA methylation differences at growth related genes correlate with birth weight: a molecular signature linked to developmental origins of adult disease?
    Nahid Turan
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    BMC Med Genomics 5:10. 2012
    ..Numerous studies have been published in which candidate genes (IGF1, IGF2, IGF2R, IGF binding proteins, PHLDA2 and PLAGL1) have been associated with birth weight, but these studies are difficult to reproduce in man and large cohort ..
  82. doi Analysis of active chromatin modifications in early mammalian embryos reveals uncoupling of H2A.Z acetylation and H3K36 trimethylation from embryonic genome activation
    Ana Boskovic
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM U964, Strasbourg, France
    Epigenetics 7:747-57. 2012
    ..b>Zac in transcriptional activation. Interestingly, however, H2A...
  83. doi Canine cutaneous peripheral nerve sheath tumours versus fibrosarcomas can be differentiated by neuroectodermal marker genes in their transcriptome
    R Klopfleisch
    Institute of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Straße 15, Berlin, Germany
    J Comp Pathol 148:197-205. 2013
    ..Conversely, eight genes associated with carcinogenesis had higher expression in fibrosarcomas: FHL2, PLAGL1, FNBP1L, BAG2, HK1, CSK and Cox5A...
  84. doi Overexpression of ZAC impairs glucose-stimulated insulin translation and secretion in clonal pancreatic beta-cells
    Xiaoyu Du
    Division of Pediatric Endocrinology, McGill University Health Center Research Institute Children s Hospital, Montreal, QC, Canada
    Diabetes Metab Res Rev 28:645-53. 2012
    b>ZAC (Zinc finger protein that regulates apoptosis and cell-cycle arrest) is a candidate gene for transient neonatal diabetes mellitus (TNDM)...
  85. pmc Genome patterns of selection and introgression of haplotypes in natural populations of the house mouse (Mus musculus)
    Fabian Staubach
    Max Planck Institute for Evolutionary Biology, Plon, Germany
    PLoS Genet 8:e1002891. 2012
    ..Genes in the regions include well-studied imprinted loci (e.g. Plagl1/Zac1), homologues of human genes involved in adaptations (e.g. alpha-amylase genes) or in genetic diseases (e.g...
  86. pmc Expression of KCNQ1OT1, CDKN1C, H19, and PLAGL1 and the methylation patterns at the KvDMR1 and H19/IGF2 imprinting control regions is conserved between human and bovine
    Katherine Marie Robbins
    Division of Animal Sciences, University of Missouri, Columbia, MO, USA
    J Biomed Sci 19:95. 2012
    ..This work is intended to be the first step in a series of experiments aimed at determining if LOS will serve as an appropriate animal model to study BWS...
  87. doi Novel pathway for somatostatin analogs in patients with acromegaly
    Monica R Gadelha
    Division of Endocrinology, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Professor Rodolpho Paulo Rocco street 255, Rio de Janeiro, Brazil
    Trends Endocrinol Metab 24:238-46. 2013
    ..Previous data have suggested the involvement of the tumor-suppressor gene ZAC1 in the mechanism of action of SSAs, and more recent findings suggested that SSAs could regulate AIP, which in turn ..
  88. ncbi Delayed up-regulation of Zac1 and PACAP type I receptor after transient focal cerebral ischemia in mice
    F Gillardon
    Max Planck Institut für neurologische Forschung, Gleueler Str 50, 50931, Koln, Germany
    Brain Res Mol Brain Res 61:207-10. 1998
    The Zac1 gene encodes a zinc finger protein that regulates both apoptosis and cell cycle arrest in vitro...
  89. ncbi Inhibition of Zac1, a new gene differentially expressed in the anterior pituitary, increases cell proliferation
    U Pagotto
    Max Planck Institute of Psychiatry, Munich, Germany
    Endocrinology 140:987-96. 1999
    b>Zac1 is a new zinc finger protein that concomitantly controls apoptosis and cell cycle arrest through separate pathways. The mouse Zac1 gene is mainly expressed in the pituitary gland and in different brain areas...
  90. ncbi LOT1 is a growth suppressor gene down-regulated by the epidermal growth factor receptor ligands and encodes a nuclear zinc-finger protein
    A Abdollahi
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvannia, PA 19111, USA
    Oncogene 18:6477-87. 1999
    ..Interestingly, the LOT1 gene localized at band q25 of human chromosome 6 which is a frequent site for LOH in many solid tumors including ..
  91. pmc Mouse Zac1, a transcriptional coactivator and repressor for nuclear receptors
    S M Huang
    Departments of Pathology and of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California 90089, USA
    Mol Cell Biol 20:1855-67. 2000
    ..the C-terminal activation domain of the nuclear receptor coactivator GRIP1, we identified a new variant of mouse Zac1 which we call mZac1b...
  92. ncbi A novel imprinted gene, HYMAI, is located within an imprinted domain on human chromosome 6 containing ZAC
    T Arima
    Wellcome CRC Institute of Cancer and Developmental Biology and Physiological Laboratory, University of Cambridge, United Kingdom
    Genomics 67:248-55. 2000
    ..A previously characterized imprinted gene, ZAC/LOT1, is located 70 kb downstream of HYMAI and is also expressed only from the paternal allele...
  93. ncbi Involvement of PLAGL2 in activation of iron deficient- and hypoxia-induced gene expression in mouse cell lines
    T Furukawa
    Department of Hygiene, Kansai Medical University, Osaka 570 8506, Japan
    Oncogene 20:4718-27. 2001
    ..Transient co-transfection of PLAGL2 or ZAC1 cDNA and a reporter containing a lactate dehydrogenase A (LDHA) promoter carrying the hypoxia inducible factor-1 ..
  94. ncbi Relaxation of imprinted expression of ZAC and HYMAI in a patient with transient neonatal diabetes mellitus
    D J G Mackay
    Wessex Regional Genetics Laboratory, Salisbury District Hospital, Wiltshire, UK
    Hum Genet 110:139-44. 2002
    ..Two genes partially overlap the island: the cell-cycle-control gene ZAC and the untranslated gene HYMAI, the function of which is currently unknown...
  95. ncbi LOT1 (PLAGL1/ZAC1), the candidate tumor suppressor gene at chromosome 6q24-25, is epigenetically regulated in cancer
    Abbas Abdollahi
    Ovarian Cancer Program, Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 278:6041-9. 2003
    ..Genome mapping of LOT1 in comparison with the other splice variants, namely ZAC1 and PLAGL1, revealed that its mRNA ( approximately 4...
  96. pmc Transcriptional activities of the zinc finger protein Zac are differentially controlled by DNA binding
    Anke Hoffmann
    Molecular Neuroendocrinology, Max Planck Institute of Psychiatry, D 80804 Munich, Germany
    Mol Cell Biol 23:988-1003. 2003
    b>Zac encodes a zinc finger protein that promotes apoptosis and cell cycle arrest and is maternally imprinted...
  97. ncbi Downregulation of Cap43 gene by von Hippel-Lindau tumor suppressor protein in human renal cancer cells
    Katsuaki Masuda
    Department of Medical Biochemistry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Int J Cancer 105:803-10. 2003
    ..beta4, secreted protein acidic and rich in cysteine, Cap43, ceruloplasmin, serum amyloid A, heat shock protein 90, LOT1, osteopontin and casein kinase Igamma) that are more highly expressed in cancerous regions than in noncancerous ..
  98. ncbi Zinc finger protein Zac1 is expressed in chondrogenic sites of the mouse
    Takeshi Tsuda
    Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Dev Dyn 229:340-8. 2004
    b>Zac1 is a zinc finger transcription factor that elicits antiproliferative activity and is a potential tumor suppressor gene...
  99. ncbi Repression of the Transactivating Capacity of the Oncoprotein PLAG1 by SUMOylation
    Frederik Van Dyck
    Laboratory for Molecular Oncology, Department for Human Genetics, University of Leuven and Flanders Interuniversity Institute for Biotechnology, Herestraat 49, B 3000 Leuven, Belgium
    J Biol Chem 279:36121-31. 2004
    ..Together with PLAGL1 and PLAGL2, PLAG1 belongs to a subfamily of C(2)H(2) zinc finger transcription factors that activate transcription ..
  100. ncbi Zac1 is up-regulated in neural cells of the limbic system of mouse brain following seizures that provoke strong cell activation
    T Valente
    Departament de Biologia Cellular, Facultat de Biologia, Universitat de Barcelona, Av Diagonal 645, 1a planta, E 08028, Spain
    Neuroscience 128:323-36. 2004
    b>Zac1, a new zinc-finger protein that regulates both apoptosis and cell cycle arrest, is abundantly expressed in many proliferative/differentiation areas during brain development...
  101. ncbi Lsh controls silencing of the imprinted Cdkn1c gene
    Tao Fan
    Laboratory of Molecular Immunoregulation, Basic Research Program, SAIC Frederick, National Cancer Institute, Frederick, MD 21702 1201, USA
    Development 132:635-44. 2005
    ..Cdkn1c gene (also known as p57(Kip2)) but does not interfere with maintenance of imprints at the H19, Igf2, Igf2r, Zac1 and Meg9 genes...

Research Grants6

  1. Masahiro Iwamoto; Fiscal Year: 2016
    ..aggrecan expression;(b) RAR[unreadable] exerts its function in cooperation with transcriptional co-repressor Zac1;and (c) RAR action on aggrecan expression is indirect and involves Sox proteins...
  2. Ethanol Modulation of Zinc-Activated Channels
    PAUL ANDREW DAVIES; Fiscal Year: 2010
    ..The zinc activated channel (ZAC) is a novel member of the alcohol sensitive Cys-loop ligand-gated cation channel superfamily and is gated by the ..
  3. Hyperphosphorylated tau as drug target
    Min Hao Kuo; Fiscal Year: 2012
    ..In this grant, we will use a novel ZAC technique to produce hyperphosphorylated tau protein that is intimately linked to the progression of Alzheimer'..
  4. Ca Handling & Arrhythmias Associated with LQT Syndrome
    KENNETH LAURITA; Fiscal Year: 2005
    ..e. lot1, lqt2, lqt3)...
  5. MOLECULAR GENETICS OF OVARIAN SURFACE NEOPLASIA
    Thomas Hamilton; Fiscal Year: 2003
    ..of heterozygosity (LOH) (chromosome 6q25) for many solid tumors including ovarian cancer; (iii) Determining that LOT1 is a nuclear transcription factor regulated by epidermal growth factor and that constitutive over-expression is a ..
  6. Zinc Finger Protein Zac1 and Chondrogenesis
    Mon Li Chu; Fiscal Year: 2004
    ..These studies will provide a better understanding of regulatory factors important for cartilage formation and repair. ..

Patents1

  1. T cell activating gene
    Patent Number: WO2004058805-A2; Date:2004-07-15