Genomes and Genes
Gene Symbol: PLAC1
Description: placenta-specific 1
Alias: CT92, OOSP2L, cancer/testis antigen 92, placenta-specific protein 1
- PLAC1, a trophoblast-specific gene, is expressed throughout pregnancy in the human placenta and modulated by keratinocyte growth factorMichael Fant
Department of Pediatrics, University of Texas, Houston Medical School, Houston, Texas 77030, USA
Mol Reprod Dev 63:430-6. 2002b>Plac1, a placenta-specific gene, is expressed exclusively by cells of trophoblastic lineage in the mouse, and maps to a region of the X chromosome known to be important in placental growth...
- A placenta-specific gene ectopically activated in many human cancers is essentially involved in malignant cell processesMichael Koslowski
Department of Internal Medicine III, Division of Experimental and Translational Oncology, Johannes Gutenberg University, Mainz, Germany
Cancer Res 67:9528-34. 2007..experimental validation approach for the discovery of new targets for antibody therapy of cancer, we identified PLAC1. PLAC1 is a placenta-specific gene with no detectable expression in any other normal human tissue...
- Plac1 is a tumor-specific antigen capable of eliciting spontaneous antibody responses in human cancer patientsXue Yuan Dong
Department of Immunology, Peking University Health Science Center, Beijing, China
Int J Cancer 122:2038-43. 2008..b>PLAC1 (PLACenta-specific 1) was one of the genes identified highly expressed in HCC tissues but not in paired ..
- PLAC1 (Placenta-specific 1): a novel, X-linked gene with roles in reproductive and cancer biologyMichael Fant
Department of Pediatrics, University of South Florida College of Medicine, Tampa, FL 33606 350, USA
Prenat Diagn 30:497-502. 2010Placenta-specific 1 (PLAC1) is a recently described X-linked gene with expression restricted primarily to cells derived from trophoblast lineage during embryonic development...
- Lower maternal PLAC1 mRNA in pregnancies complicated with vaginal bleeding (threatened abortion <20 weeks) and a surviving fetusAntonio Farina
Department of Histology, Embryology and Applied Biology, University of Bologna, Bologna, Italy
Clin Chem 51:224-7. 2005
- MicroRNA-191, an estrogen-responsive microRNA, functions as an oncogenic regulator in human breast cancerNeha Nagpal
Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology, New Delhi, India
Carcinogenesis 34:1889-99. 2013..thereby contributing to estrogen-specific gene signature to regulate genes like ANXA1, PIWIL2, CASP4, ESR1/ESR2, PLAC1 and SOCS2 involved in breast cancer progression and migration...
- PPARδ induces estrogen receptor-positive mammary neoplasia through an inflammatory and metabolic phenotype linked to mTOR activationHongyan Yuan
Department of Oncology and Lombardi Comprehensive Cancer Center, Lombardi Comprehensive Cancer Center, Washington, DC 20007, USA
Cancer Res 73:4349-61. 2013..inflammatory, invasive, metabolic, and proliferative gene signature, including expression of the trophoblast gene, Plac1, beginning 1 week after GW501516 treatment, and remained elevated throughout tumorigenesis...
- T antigen transformation reveals Tp53/RB-dependent route to PLAC1 transcription activation in primary fibroblastsY Chen
Laboratory of Genetics, National Institute on Aging, Baltimore, MD, USA
Oncogenesis 2:e67. 2013b>PLAC1 (placenta-specific 1) is a gene that is placenta specific and transcribed very little, if at all, in any somatic tissue. It is nevertheless expressed in many cancer cell lines...
- NCOA3 is a selective co-activator of estrogen receptor α-mediated transactivation of PLAC1 in MCF-7 breast cancer cellsMeike Wagner
Department of Internal Medicine III, Division of Translational and Experimental Oncology, University Medical Center, Johannes Gutenberg University, 55131 Mainz, Germany
BMC Cancer 13:570. 2013The placenta-specific 1 (PLAC1) gene encodes a membrane-associated protein which is selectively expressed in the placental syncytiotrophoblast and in murine fetal tissues during embryonic development...
- Plac1 (placenta-specific 1) is widely expressed during fetal development and is associated with a lethal form of hydrocephalusXiaoyuan Kong
Department of Pediatrics, University of South Florida Morsani College of Medicine, Tampa, Florida
Birth Defects Res A Clin Mol Teratol 97:571-7. 2013b>Plac1 is an X-linked gene essential for normal placental development. Plac1 ablation is associated with placentomegaly and intrauterine growth retardation. Additionally, Plac1-null mice exhibit reduced postnatal viability...
- MAGE-A3 is highly expressed in a subset of colorectal cancer patientsH M C Shantha Kumara
Division of Colon and Rectal Surgery, Department of Surgery, St Luke s Roosevelt Hospital Center, New York, NY 10019, USA
Cancer Immun 12:16. 2012..We evaluated the expression of MAGE-A3, PLAC1, GAGE, and CTAG2 in a series of colorectal cancers (CRC)...
- Plac1 (placenta-specific 1) is essential for normal placental and embryonic developmentSuzanne M Jackman
Department of Pediatrics, University of South Florida Morsani College of Medicine, Tampa, FL, USA
Mol Reprod Dev 79:564-72. 2012b>Plac1 is a recently identified, X-linked gene whose expression is restricted primarily to cells of the trophoblast lineage. It localizes to a chromosomal locus previously implicated in placental growth...
- Preliminary evidence for high anti-PLAC1 antibody levels in infertile patients with repeated unexplained implantation failureM Matteo
Institute of Obstetrics and Gynecology, Department of Medical and Surgical Sciences, University of Foggia, Viale Pinto, 71100 Foggia, Italy
Placenta 34:335-9. 2013Placenta-specific1 (PLAC1) is a trophoblast-specific gene encoding for a protein that is highly expressed in human placenta, on the surface of the syncytiotrophoblast...
- Identification of a novel HLA-A2-restricted cytotoxic T lymphocyte epitope from cancer-testis antigen PLAC1 in breast cancerWei Liu
Department of Bioengineering, Zhengzhou University, 100 Science Road, Zhengzhou, 450001, China
Amino Acids 42:2257-65. 2012..Among all the tumor antigens, the caner-testis (CT) antigens are the most widely studied and promising targets. PLAC1 (placenta-specific 1, CT92) was considered as a novel member of caner-testis antigen, which expressed in a wide ..
- Selective activation of trophoblast-specific PLAC1 in breast cancer by CCAAT/enhancer-binding protein beta (C/EBPbeta) isoform 2Michael Koslowski
Department of Internal Medicine III, Experimental and Translational Oncology, Johannes Gutenberg University, 55131 Mainz, Germany
J Biol Chem 284:28607-15. 2009The trophoblast-specific gene PLAC1 (placenta-specific 1) is ectopically expressed in a wide range of human malignancies, most frequently in breast cancer, and is essentially involved in cancer cell proliferation, migration, and invasion...
- Expression and serum immunoreactivity of developmentally restricted differentiation antigens in epithelial ovarian cancerNana E Tchabo
Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Cancer Immun 9:6. 2009Cancer-embryo antigens or developmentally restricted differentiation antigens (DRDAGs), such as PLAC1 (CT92) and developmental pluripotency associated-2 (DPPA2/CT100), are expressed in pluripotent embryonic cells...
- Placenta-derived fetal specific mRNA is more readily detectable in maternal plasma than in whole bloodMacy M S Heung
Centre for Research into Circulating Fetal Nucleic Acids, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region, China
PLoS ONE 4:e5858. 2009..We investigated fetal mRNA detection in maternal whole blood and determined if it offered advantages over maternal plasma analysis...
- Characterization of pLAC1, a cryptic plasmid isolated from Lactobacillus acidipiscis and comparative analysis with its related plasmidsIoanna Areti Asteri
Department of Food Science and Technology, Agricultural University of Athens, Greece
Int J Food Microbiol 141:222-8. 2010The pLAC1 plasmid of Lactobacillus acidipiscis ACA-DC 1533, a strain isolated from traditional Kopanisti cheese, was characterised. Nucleotide sequence analysis revealed a circular molecule of 3478bp with a G+C content of 37.2%...
- [Expression of PLAC1/CP1 genes in primary colorectal carcinoma and its clinical significance]Fang Fang Liu
Department of Pathology, Peking University People s Hospital, Beijing 100044, China
Zhonghua Bing Li Xue Za Zhi 39:810-3. 2010To study the expression and significance of PLAC1/CP1 genes in patients with primary colorectal carcinoma.
- Plasma mRNA concentrations of placenta-specific 1 (PLAC1) and pregnancy associated plasma protein A (PAPP-A) are higher in early-onset than late-onset pre-eclampsiaMiho Kodama
Department of Obstetrics and Gynecology, Hiroshima Prefectural Hospital, Hiroshima, Japan
J Obstet Gynaecol Res 37:313-8. 2011..observed to increase in the maternal circulation in association with pre-eclampsia, including placenta-specific 1 (PLAC1) and pregnancy associated plasma protein A (PAPP-A), which were previously proposed as predictive markers for pre-..
- RXRα and LXR activate two promoters in placenta- and tumor-specific expression of PLAC1Y Chen
Laboratory of Genetics, National Institute on Aging, Bayview Research Center, 251 Bayview Blvd, RM 10B117, Baltimore, MD 21224, USA
Placenta 32:877-84. 2011b>PLAC1 expression, first characterized as restricted to developing placenta among normal tissues, is also found in a wide range of tumors and transformed cell lines...
- The evolution, regulation, and function of placenta-specific genesSaara M Rawn
Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, and the Graduate Program in Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta T2N 4N1, Canada
Annu Rev Cell Dev Biol 24:159-81. 2008A number of placenta-specific genes (e.g., Tpbp, Plac1, Syncytin, and retrotransposon-associated genes such as Peg10, Rtl1, Endothelin B receptor, Insl4, Leptin, Midline1, and Pleiotrophin), enhancer elements (e.g...
- Staphylococcus aureus chromosomal mutation plaC1 amplifies plasmid pT181 by depressing synthesis of its negative-effector countertranscriptsS Iordanescu
Department of Plasmid Biology, Public Health Research Institute, New York, New York 10016
J Bacteriol 171:4831-5. 1989A Staphylococcus aureus chromosomal mutation, plaC1, which leads specifically to the amplification of plasmid pT181 has previously been described (S. Iordanescu, Plasmid 10:130-137, 1983)...
- PLAC1, an Xq26 gene with placenta-specific expressionM Cocchia
Laboratory of Genetics, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, Maryland 21224, USA
Genomics 68:305-12. 2000A novel human X-linked gene shows placenta-specific expression and has been named PLAC1. The gene maps 65 kb telomeric to HPRT at Xq26 and has been completely sequenced at the cDNA and genomic levels...
- Oosp1 encodes a novel mouse oocyte-secreted proteinC Yan
Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
Genesis 31:105-10. 2001..OOSP1 shares amino acid identity with placental-specific protein 1 (PLAC1), a secreted protein expressed in the placenta and the ectoplacental cone. The Oosp1 mRNA is approximately 1...
- Expression profiling of placentomegaly associated with nuclear transplantation of mouse ES cellsHiroshi Suemizu
Developmental Genomics and Aging Section, Laboratory of Genetics, National Institute on Aging, NIH, Baltimore, Maryland 21224, USA
Dev Biol 253:36-53. 2003..of oncogenes and growth promoting genes; (4) overexpression of genes involved in placental growth, such as Plac1; and (5) identification of many novel genes overexpressed in ES-derived NT mouse placentas, including Pitrm1, a ..
- Plac8 and Plac9, novel placental-enriched genes identified through microarray analysisCarlos Galaviz-Hernandez
Laboratory of Genetics, National Institute on Aging, NIH, Suite 3000, 333 Cassell Drive, Baltimore, MD 21224, USA
Gene 309:81-9. 2003..One, Plac1, strongly expressed in all trophoblast-derived cells in the placenta, has been described earlier (Genomics 68 (..
- Rapid clearance of mRNA for PLAC1 gene in maternal blood after deliveryManuela Concu
Institute of Histology and Human Embryology, University of Bologna, Bologna, Italy
Fetal Diagn Ther 20:27-30. 2005To evaluate (1) whether the presence of mRNA for the specific trophoblast gene PLAC1 in maternal whole blood is pregnancy-specific, and (2) whether delivery would result in the clearance of mRNA from maternal blood.
- PLAC1 expression increases during trophoblast differentiation: evidence for regulatory interactions with the fibroblast growth factor-7 (FGF-7) axisEltayab Massabbal
Department of Pediatrics, University of Texas Houston Medical School, Houston, Texas 77030, USA
Mol Reprod Dev 71:299-304. 2005b>PLAC1 is a recently described, trophoblast-specific gene that localizes to a region of the X-chromosome important in placental development...
- Increased plasma mRNAs of placenta-specific 1 (PLAC1) and glial cells-missing 1 (GCM1) in mothers with pre-eclampsiaNaoya Fujito
Department of Obstetrics and Gynecology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
Hiroshima J Med Sci 55:9-15. 2006..hPL) mRNAs as previously reported mRNAs and pregnancy associated plasma protein A (PAPP-A), placenta-specific 1 (PLAC1) and glial cells-missing 1 (GCM1) mRNAs, which have not been measured during the course of normal pregnancy...
- The PLAC1-homology region of the ZP domain is sufficient for protein polymerisationLuca Jovine
Brookdale Department of Molecular, Cell and Developmental Biology, Mount Sinai School of Medicine, One Gustave L, Levy Place, New York, NY 10029 6574, USA
BMC Biochem 7:11. 2006..Recently, PLAC1, Oosp1-3, Papillote and CG16798 proteins were identified that share sequence homology with the N-terminal half of ..
- PLAC1 mRNA levels in maternal blood at induction of labor correlate negatively with induction-delivery intervalNicola Rizzo
Prenatal Medicine Unit, Embryology and Applied Biology, University of Bologna, Bologna, Italy
Eur J Obstet Gynecol Reprod Biol 132:177-81. 2007..using prostaglandin gel (dinoprostone gel), there is a relationship between the concentration of mRNA for the PLAC1 gene (a trophoblast-specific gene) in maternal blood and the time elapsed between the first gel administration and ..
- PLAC1 mRNA in maternal blood correlates with Doppler waveform in uterine arteries in normal pregnancies at the second and third trimesterAntonio Farina
Department of Histology and Medical Embryology, Division of Prenatal Medicine, University of Bologna, Bologna, Italy
Ann N Y Acad Sci 1075:130-6. 2006Doppler analysis of the uterine arteries is currently used for pre-eclampsia (PE) screening. PLAC1 is a trophoblast-specific gene, and it is known that in normal pregnancies, trophoblastic cells are released into the maternal circulation,..
- The PLAC1 protein localizes to membranous compartments in the apical region of the syncytiotrophoblastMichael Fant
Department of Pediatrics, University of Texas Health Science Center, Houston, Texas 77030, USA
Mol Reprod Dev 74:922-9. 2007b>PLAC1 is a trophoblast-specific gene that maps to a locus on the X-chromosome important to placental development. We have previously shown that PLAC1 gene expression is linked to trophoblast differentiation...
- Cell-free mRNA concentrations of CRH, PLAC1, and selectin-P are increased in the plasma of pregnant women with preeclampsiaYuditiya Purwosunu
Department of Obstetrics and Gynecology, Showa University School of Medicine, Tokyo, Japan
Prenat Diagn 27:772-7. 2007To compare mRNA concentrations of corticotrophin-releasing hormone (CRH), placenta specific-1 (PLAC1), and selectin-P in preeclamptic and normal pregnancies.
- PLAC1, a trophoblast-specific cell surface protein, is expressed in a range of human tumors and elicits spontaneous antibody responsesWilson A Silva
Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Cancer Immun 7:18. 2007..The gene with the most distinctive expression pattern was found to be PLAC1, which encodes a putative cell surface protein that is highly expressed in placenta, testis, cancer cell lines and ..
- The Staphylococcus aureus chromosomal gene plaC, identified by mutations amplifying plasmid pT181, encodes a sigma factorR Basheer
Public Health Research Institute, New York, NY 10016
Nucleic Acids Res 19:4921-4. 1991The Staphylococcus aureus chromosomal gene plaC, identified by mutations such as plaC1 that lead to the amplification of plasmid pT181, has been cloned and sequenced...
- The Role of PLAC1 in Placental GrowthMichael Fant; Fiscal Year: 2003..strengthened by a fetal growth retardation phenotype associated with X chromosome deletions in the region to which PLAC1 maps...
- PLAC1 in Placental DevelopmentMichael Fant; Fiscal Year: 2007..DESCRIPTION (provided by applicant): The objective of this proposal is to determine the functional role of PLAC1, a novel trophoblast-specific and X-linked gene, in placental and fetal development...