PLA2G2F

Summary

Gene Symbol: PLA2G2F
Description: phospholipase A2 group IIF
Alias: group IIF secretory phospholipase A2, GIIF sPLA2, phosphatidylcholine 2-acylhydrolase 2F, sPLA2-IIF
Species: human

Top Publications

  1. pmc sPLA2 and the epidermal barrier
    Dusko Ilic
    Human Embryonic Stem Cell Laboratories, Guy s Assisted Conception Unit, Division of Women s Health, King s College London School of Medicine, London, UK Electronic address
    Biochim Biophys Acta 1841:416-21. 2014
  2. pmc The role of group IIF-secreted phospholipase A2 in epidermal homeostasis and hyperplasia
    Kei Yamamoto
    Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156 8506, Japan
    J Exp Med 212:1901-19. 2015
  3. ncbi HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes
    E Mavoungou
    Department of Immunology and Immunogenetics, International Center for Medical Research, Franceville, Gabon
    J Acquir Immune Defic Syndr Hum Retrovirol 16:1-9. 1997
  4. ncbi Cloning and recombinant expression of human group IIF-secreted phospholipase A(2)
    E Valentin
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UPR 411, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    Biochem Biophys Res Commun 279:223-8. 2000
  5. ncbi Cellular arachidonate-releasing function and inflammation-associated expression of group IIF secretory phospholipase A2
    Makoto Murakami
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    J Biol Chem 277:19145-55. 2002
  6. pmc Distinct expression pattern of the full set of secreted phospholipases A2 in human colorectal adenocarcinomas: sPLA2-III as a biomarker candidate
    C M Mounier
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UNSA UMR6097, Sophia Antipolis, Valbonne, France
    Br J Cancer 98:587-95. 2008
  7. pmc Analyses of group III secreted phospholipase A2 transgenic mice reveal potential participation of this enzyme in plasma lipoprotein modification, macrophage foam cell formation, and atherosclerosis
    Hiroyasu Sato
    Biomembrane Signaling Project, Tokyo Metropolitan Institute of Medical Science, 3 18 22 Honkomagome, Tokyo 113 8613, Japan
    J Biol Chem 283:33483-97. 2008

Scientific Experts

  • Dusko Ilic
  • Makoto Murakami
  • E Mavoungou
  • Kei Yamamoto
  • Yoshitaka Taketomi
  • Kazutaka Ikeda
  • Ryo Taguchi
  • C M Mounier
  • Hiroyasu Sato
  • G Lambeau
  • Kazuaki Muramatsu
  • Kenji Kabashima
  • Yasumasa Nishito
  • Gerard Lambeau
  • Mariko Sato
  • Choji Taya
  • Michael H Gelb
  • Hiroki Nakanishi
  • Naotomo Kambe
  • Yoshimi Miki
  • E Valentin
  • D W Rosenberg
  • Ichiro Kudo
  • Toshiharu Ishii
  • Mitsuhiro Ohtsuki
  • Rina Kato
  • D Wendum
  • Yuki Isogai
  • Yukio Ishikawa
  • Joe Yamada
  • Hiroyuki Itabe
  • Go ichi Saka
  • Seiko Masuda
  • E Greenspan
  • Tetsuyuki Kobayashi
  • Shuntaro Hara
  • Kae Tsutsumi
  • Shinji Hatakeyama
  • J F Flejou
  • F Ghomashchi
  • M Lazdunski
  • M H Gelb
  • A G Singer

Detail Information

Publications7

  1. pmc sPLA2 and the epidermal barrier
    Dusko Ilic
    Human Embryonic Stem Cell Laboratories, Guy s Assisted Conception Unit, Division of Women s Health, King s College London School of Medicine, London, UK Electronic address
    Biochim Biophys Acta 1841:416-21. 2014
    ..Several sPLA2 isoforms are present in the epidermis. We find that two of these isoforms, sPLA2 IIA and sPLA2 IIF, localize to the upper stratum granulosum and increase in response to experimental barrier perturbation...
  2. pmc The role of group IIF-secreted phospholipase A2 in epidermal homeostasis and hyperplasia
    Kei Yamamoto
    Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156 8506, Japan
    J Exp Med 212:1901-19. 2015
    ..Here, we report that PLA2G2F, a functionally orphan-secreted phospholipase A2 expressed in the suprabasal epidermis, regulates skin ..
  3. ncbi HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes
    E Mavoungou
    Department of Immunology and Immunogenetics, International Center for Medical Research, Franceville, Gabon
    J Acquir Immune Defic Syndr Hum Retrovirol 16:1-9. 1997
    ..However, this effect is not sufficient to accomplish fusion. These data indicate that the specific step of fusion may be downstream from PLA2 activation...
  4. ncbi Cloning and recombinant expression of human group IIF-secreted phospholipase A(2)
    E Valentin
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UPR 411, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    Biochem Biophys Res Commun 279:223-8. 2000
    ..Finally, recombinant expression of hGIIF sPLA(2) in Escherichia coli shows that the enzyme is Ca(2+)-dependent, maximally active at pH 7-8, and hydrolyzes phosphatidylglycerol versus phosphatidylcholine with a 15-fold preference...
  5. ncbi Cellular arachidonate-releasing function and inflammation-associated expression of group IIF secretory phospholipase A2
    Makoto Murakami
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    J Biol Chem 277:19145-55. 2002
    ..These results suggest that sPLA(2)-IIF is a potent regulator of AA metabolism and participates in the inflammatory process under certain conditions...
  6. pmc Distinct expression pattern of the full set of secreted phospholipases A2 in human colorectal adenocarcinomas: sPLA2-III as a biomarker candidate
    C M Mounier
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UNSA UMR6097, Sophia Antipolis, Valbonne, France
    Br J Cancer 98:587-95. 2008
    ..PLA2G12A were expressed at high levels, PLA2G2D, PLA2G5, PLA2G10 and PLA2G12B at moderate levels, and PLA2G1B, PLA2G2F and PLA2G3 at low levels...
  7. pmc Analyses of group III secreted phospholipase A2 transgenic mice reveal potential participation of this enzyme in plasma lipoprotein modification, macrophage foam cell formation, and atherosclerosis
    Hiroyasu Sato
    Biomembrane Signaling Project, Tokyo Metropolitan Institute of Medical Science, 3 18 22 Honkomagome, Tokyo 113 8613, Japan
    J Biol Chem 283:33483-97. 2008
    ..converted to lysophosphatidylcholine by PLA2G3 as well as by PLA2G5 and PLA2G10, to a lesser extent by PLA2G2F, and only minimally by PLA2G2A and PLA2G2E...