PLA2G2E

Summary

Gene Symbol: PLA2G2E
Description: phospholipase A2 group IIE
Alias: GIIE sPLA2, sPLA2-IIE, group IIE secretory phospholipase A2, phosphatidylcholine 2-acylhydrolase 2E
Species: human

Top Publications

  1. ncbi Structures, enzymatic properties, and expression of novel human and mouse secretory phospholipase A(2)s
    N Suzuki
    Shionogi Research Laboratories, Shionogi and Company, Limited, Sagisu 5 12 4, Fukushima ku, Osaka 553 0002, Japan
    J Biol Chem 275:5785-93. 2000
  2. ncbi Arachidonate release and eicosanoid generation by group IIE phospholipase A(2)
    Makoto Murakami
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Biochem Biophys Res Commun 292:689-96. 2002
  3. pmc The adipocyte-inducible secreted phospholipases PLA2G5 and PLA2G2E play distinct roles in obesity
    Hiroyasu Sato
    Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science, 2 1 6 Kamikitazawa, Setagaya Ku, Tokyo 156 8506, Japan Department of Health Chemistry, Showa University, School of Pharmacy, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Cell Metab 20:119-32. 2014
  4. ncbi The expression of groups IIE and V phospholipase A2 is associated with an increased expression of osteogenic molecules in human calcified aortic valves
    Koji Suzuki
    Department of Internal Medicine II, University of Yamanashi, Faculty of Medicine
    J Atheroscler Thromb 21:1308-25. 2014
  5. doi Group IIE secretory phospholipase A2 regulates lipolysis in adipocytes
    Hui Zhi
    Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China Correspondence Ling Chen State Key Laboratory of Respiratory Diseases, Institute of Respiratory Diseases, Guangzhou College of Medicine, Guangzhou, China
    Obesity (Silver Spring) 23:760-8. 2015
  6. pmc Genome-wide association identifies multiple ulcerative colitis susceptibility loci
    Dermot P B McGovern
    Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    Nat Genet 42:332-7. 2010
  7. doi Genome-wide association study of ulcerative colitis in Koreans suggests extensive overlapping of genetic susceptibility with Caucasians
    Suk Kyun Yang
    Department of Gastroenterology, Asan Medical Center, Seoul, South Korea
    Inflamm Bowel Dis 19:954-66. 2013
  8. ncbi HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes
    E Mavoungou
    Department of Immunology and Immunogenetics, International Center for Medical Research, Franceville, Gabon
    J Acquir Immune Defic Syndr Hum Retrovirol 16:1-9. 1997
  9. pmc Analyses of group III secreted phospholipase A2 transgenic mice reveal potential participation of this enzyme in plasma lipoprotein modification, macrophage foam cell formation, and atherosclerosis
    Hiroyasu Sato
    Biomembrane Signaling Project, Tokyo Metropolitan Institute of Medical Science, 3 18 22 Honkomagome, Tokyo 113 8613, Japan
    J Biol Chem 283:33483-97. 2008
  10. pmc Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study
    Mark S Silverberg
    Mount Sinai Hospital Inflammatory Bowel Disease Group, University of Toronto, 600 University Avenue, Toronto, ON M5G1X5, Canada
    Nat Genet 41:216-20. 2009

Scientific Experts

  • Dermot P B McGovern
  • Ling Chen
  • Makoto Murakami
  • E Mavoungou
  • Hiroyasu Sato
  • Hui Zhi
  • Koji Suzuki
  • Suk Kyun Yang
  • Tetsuyuki Kobayashi
  • Yoshitaka Taketomi
  • Kei Yamamoto
  • Yuki Isogai
  • Ryo Taguchi
  • Kazutaka Ikeda
  • Shuntaro Hara
  • Mark S Silverberg
  • Linbing Qu
  • Jun Tao
  • Fang Wu
  • Takamitsu Nakamura
  • Soichiro Takahashi
  • Yuji Miyamoto
  • Yasumasa Nishito
  • Yoshimi Miki
  • Satoshi Ida
  • Ryohei Katoh
  • Yuichi Oike
  • Kiyotaka Kugiyama
  • Ayako Ushida
  • Masayuki Watanabe
  • Tetsuya Hirabayashi
  • Ken Ichi Kawabata
  • Masahiko Matsumoto
  • Keishi Miyata
  • Takumi Kojima
  • Jun ei Obata
  • Hideo Baba
  • Kazuhiro Watanabe
  • Michael H Gelb
  • Daisuke Fujioka
  • Wanting Zhao
  • Yusun Jung
  • Lyoung Hyo Kim
  • Jianjun Liu
  • Hee Shang Youn
  • Myunghee Hong
  • Byong Duk Ye
  • Sang Hyoung Park
  • Daehee Kang
  • Hyun Sub Cheong
  • Hyoung Doo Shin
  • Kyuyoung Song
  • Naeimeh Tayebi
  • Hyo Jong Kim
  • Sung Ae Jung
  • Inchul Lee
  • Kyung Jo Kim
  • N Suzuki
  • Richard H Duerr
  • Emily O Kistner
  • Regan Scott
  • Raymond G Lahaie
  • L Philip Schumm
  • Jean Paul Achkar
  • Anna Latiano
  • A Hillary Steinhart
  • Philippe Goyette
  • Miguel D Regueiro
  • Vito Annese
  • Stephan R Targan
  • M Michael Barmada
  • Pierre Pare
  • Jing Wu
  • Jerome I Rotter
  • Judy H Cho
  • Andrew F Ippoliti
  • Kathryn Roeder
  • Fabrizio Bossa
  • Theodore M Bayless
  • Annette T Lee
  • Mark J Daly
  • Peter K Gregersen
  • John D Rioux
  • Lambertus Klei
  • Steven R Brant
  • Kent D Taylor
  • Deborah D Proctor
  • Clara Abraham
  • Wei Xu
  • Anne M Griffiths

Detail Information

Publications11

  1. ncbi Structures, enzymatic properties, and expression of novel human and mouse secretory phospholipase A(2)s
    N Suzuki
    Shionogi Research Laboratories, Shionogi and Company, Limited, Sagisu 5 12 4, Fukushima ku, Osaka 553 0002, Japan
    J Biol Chem 275:5785-93. 2000
    ..These findings suggest a distinct functional role of novel sPLA(2)-IIE in the progression of inflammatory processes...
  2. ncbi Arachidonate release and eicosanoid generation by group IIE phospholipase A(2)
    Makoto Murakami
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Biochem Biophys Res Commun 292:689-96. 2002
    ..These observations suggest that this enzyme plays a role in the inflammatory process, as proposed for other group II subfamily sPLA(2)s...
  3. pmc The adipocyte-inducible secreted phospholipases PLA2G5 and PLA2G2E play distinct roles in obesity
    Hiroyasu Sato
    Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science, 2 1 6 Kamikitazawa, Setagaya Ku, Tokyo 156 8506, Japan Department of Health Chemistry, Showa University, School of Pharmacy, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Cell Metab 20:119-32. 2014
    ..whose expressions are associated with obesity, we found that two secreted phospholipase A2s (sPLA2s), PLA2G5 and PLA2G2E, were robustly induced in adipocytes of obese mice...
  4. ncbi The expression of groups IIE and V phospholipase A2 is associated with an increased expression of osteogenic molecules in human calcified aortic valves
    Koji Suzuki
    Department of Internal Medicine II, University of Yamanashi, Faculty of Medicine
    J Atheroscler Thromb 21:1308-25. 2014
    ..We therefore sought to determine whether PLA2s are expressed in human aortic valves and, if so, whether the expression of PLA2s is related to the expression of osteogenic molecules in these tissues...
  5. doi Group IIE secretory phospholipase A2 regulates lipolysis in adipocytes
    Hui Zhi
    Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China Correspondence Ling Chen State Key Laboratory of Respiratory Diseases, Institute of Respiratory Diseases, Guangzhou College of Medicine, Guangzhou, China
    Obesity (Silver Spring) 23:760-8. 2015
    ..To examine the function of group IIE secretory phospholipase A(2) (sPLA(2) -IIE) in adipocytes and to explore the possible signaling mechanism involved...
  6. pmc Genome-wide association identifies multiple ulcerative colitis susceptibility loci
    Dermot P B McGovern
    Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    Nat Genet 42:332-7. 2010
    ..These data implicate approximately 30 loci in ulcerative colitis, thereby providing insight into disease pathogenesis...
  7. doi Genome-wide association study of ulcerative colitis in Koreans suggests extensive overlapping of genetic susceptibility with Caucasians
    Suk Kyun Yang
    Department of Gastroenterology, Asan Medical Center, Seoul, South Korea
    Inflamm Bowel Dis 19:954-66. 2013
    ..We performed a genome-wide association studies to identify UC susceptibility loci in a Korean population and further comparative study...
  8. ncbi HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes
    E Mavoungou
    Department of Immunology and Immunogenetics, International Center for Medical Research, Franceville, Gabon
    J Acquir Immune Defic Syndr Hum Retrovirol 16:1-9. 1997
    ..However, this effect is not sufficient to accomplish fusion. These data indicate that the specific step of fusion may be downstream from PLA2 activation...
  9. pmc Analyses of group III secreted phospholipase A2 transgenic mice reveal potential participation of this enzyme in plasma lipoprotein modification, macrophage foam cell formation, and atherosclerosis
    Hiroyasu Sato
    Biomembrane Signaling Project, Tokyo Metropolitan Institute of Medical Science, 3 18 22 Honkomagome, Tokyo 113 8613, Japan
    J Biol Chem 283:33483-97. 2008
    ..by PLA2G3 as well as by PLA2G5 and PLA2G10, to a lesser extent by PLA2G2F, and only minimally by PLA2G2A and PLA2G2E. PLA2G3-modified LDL, like PLA2G5- or PLA2G10-treated LDL, facilitated the formation of foam cells from ..
  10. pmc Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study
    Mark S Silverberg
    Mount Sinai Hospital Inflammatory Bowel Disease Group, University of Toronto, 600 University Avenue, Toronto, ON M5G1X5, Canada
    Nat Genet 41:216-20. 2009
    ..0 x 10(-16), combined OR = 0.66) and at the IL23R locus on chromosome 1p31 (rs11209026, combined P = 1.3 x 10(-8), combined OR = 0.56; rs10889677, combined P = 1.3 x 10(-8), combined OR = 1.29)...