PLA2G2D

Summary

Gene Symbol: PLA2G2D
Description: phospholipase A2 group IID
Alias: PLA2IID, SPLASH, sPLA2-IID, sPLA2S, group IID secretory phospholipase A2, GIID sPLA2, phosphatidylcholine 2-acylhydrolase 2D, secretory phospholipase A2s, secretory-type PLA, stroma-associated homolog
Species: human

Top Publications

  1. ncbi Camphor Poisoning: an evidence-based practice guideline for out-of-hospital management
    Anthony S Manoguerra
    American Association of Poison Control Centers, Washington, District of Columbia 20016, USA
    Clin Toxicol (Phila) 44:357-70. 2006
  2. ncbi Heavy metals in bark of Pinus massoniana (Lamb.) as an indicator of atmospheric deposition near a smeltery at Qujiang, China
    Yuan Wen Kuang
    South China Botanical Garden, The Chinese Academy of Sciences, Guangzhou 510650, China
    Environ Sci Pollut Res Int 14:270-5. 2007
  3. ncbi Bactericidal properties of human and murine groups I, II, V, X, and XII secreted phospholipases A(2)
    Rao S Koduri
    Department of Chemistry, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 277:5849-57. 2002
  4. ncbi An envelope-determined endocytic route of viral entry allows HIV-1 to escape from secreted phospholipase A2 entry blockade
    Thomas Maurin
    INSERM U526, Laboratoire de Virologie, Faculte de Medecine, Avenue de Valombrose, 06107 Nice Cedex 2, France
    J Mol Biol 367:702-14. 2007
  5. ncbi Secretory low-molecular-weight phospholipases A2 and their specific receptor in bile ducts of patients with intrahepatic calculi: factors of chronic proliferative cholangitis
    J Shoda
    Department of Gastroenterology, Institute of Clinical Medicine, The University of Tsukuba, Ibaraki, Japan
    Hepatology 29:1026-36. 1999
  6. pmc Occupational exposure to the risk of HIV infection among health care workers in Mwanza Region, United Republic of Tanzania
    B Gumodoka
    Bugando Medical Centre, Mwanza, United Republic of Tanzania
    Bull World Health Organ 75:133-40. 1997
  7. ncbi Effect of crotapotin and heparin on the rat paw oedema induced by different secretory phospholipases A2
    E C Landucci
    Department of Pharmacology, Faculty of Medical Sciences, UNICAMP, Campinas, SP, Brazil
    Toxicon 38:199-208. 2000
  8. pmc Patient characteristics, diagnosis, and treatment of non-contact lens related Acanthamoeba keratitis
    S Sharma
    Jhaveri Microbiology Centre, LV Prasad Eye Institute, LV Prasad Marg, Banjara Hills, Hyderabad 500 034, India
    Br J Ophthalmol 84:1103-8. 2000
  9. ncbi Risk for eye splash injury during administration of intraocular injections: a study of retina specialists and fellows
    Dan H Bourla
    Jules Stein Eye Institute, Department of Ophthalmology, David Geffen School of Medicine, University of California Los Angeles, 200 Stein Plaza, Los Angeles, CA 90095, USA
    Retina 27:609-12. 2007
  10. ncbi [Lightning injuries: case report of a 17-year-old man and a brief review of the literature]
    N Stutz
    Abteilung für Plastische, Hand und Wiederherstellungschirurgie, Zentrum für Schwerbrandverletzte, Klinikum Nürnberg Süd, Breslauerstrasse 201, 90471 Nürnberg
    Unfallchirurg 109:495-8. 2006

Research Grants

  1. Regulation and Function of Cytosolic Phospholipase A2
    Michael H Gelb; Fiscal Year: 2012
  2. Mechanisms of abdominal aortic aneurysm formation
    Alan Daugherty; Fiscal Year: 2010
  3. Teal S Hallstrand; Fiscal Year: 2016
  4. Scott J Russo; Fiscal Year: 2014
  5. Michael H Gelb; Fiscal Year: 2016
  6. BIOCHEMICAL STUDIES OF 14 KDA PHOSPHOLIPASES A2
    Michael Gelb; Fiscal Year: 2006
  7. Multimedia Motivational Interviewing Training for Physical Therapists
    ROBIN INLANDER; Fiscal Year: 2007
  8. SPLA2 AND SURFACTANT IN ASTHMA
    David Bass; Fiscal Year: 2003
  9. MECHANISMS OF AIRWAY HYPERRESPONSIVENESS
    Alan Leff; Fiscal Year: 2005
  10. Role of Vimentin, sPLA2 and LysoPC in Autoimmune Disease
    SUZANNE BARBOUR; Fiscal Year: 2005

Detail Information

Publications188 found, 100 shown here

  1. ncbi Camphor Poisoning: an evidence-based practice guideline for out-of-hospital management
    Anthony S Manoguerra
    American Association of Poison Control Centers, Washington, District of Columbia 20016, USA
    Clin Toxicol (Phila) 44:357-70. 2006
    ..8) For patients with topical splash exposures of camphor to the eye(s), the eye(s) should be irrigated in accordance with usual poison center ..
  2. ncbi Heavy metals in bark of Pinus massoniana (Lamb.) as an indicator of atmospheric deposition near a smeltery at Qujiang, China
    Yuan Wen Kuang
    South China Botanical Garden, The Chinese Academy of Sciences, Guangzhou 510650, China
    Environ Sci Pollut Res Int 14:270-5. 2007
    ..The impact of the emission from smeltery on the soils beneath the trees and the relationships of the concentrations between the soils and the barks were also analyzed...
  3. ncbi Bactericidal properties of human and murine groups I, II, V, X, and XII secreted phospholipases A(2)
    Rao S Koduri
    Department of Chemistry, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 277:5849-57. 2002
    ..analyzed the bactericidal activity of the full set of recombinant murine and human groups I, II, V, X, and XII sPLA2s on Listeria monocytogenes, Staphylococcus aureus, and Escherichia coli...
  4. ncbi An envelope-determined endocytic route of viral entry allows HIV-1 to escape from secreted phospholipase A2 entry blockade
    Thomas Maurin
    INSERM U526, Laboratoire de Virologie, Faculte de Medecine, Avenue de Valombrose, 06107 Nice Cedex 2, France
    J Mol Biol 367:702-14. 2007
    ..Taken together, we conclude that HIV-1 may escape from entry inhibitors, such as sPLA2s, through the selection of a particular HIV-1 envelope glycoprotein that allows HIV to infect cells via an ..
  5. ncbi Secretory low-molecular-weight phospholipases A2 and their specific receptor in bile ducts of patients with intrahepatic calculi: factors of chronic proliferative cholangitis
    J Shoda
    Department of Gastroenterology, Institute of Clinical Medicine, The University of Tsukuba, Ibaraki, Japan
    Hepatology 29:1026-36. 1999
    ..of the pathophysiology, interest has been focused on the role of secretory low-molecular-weight phospholipases A2 (sPLA2s) as inflammatory mediators or factors modulating cell functions via their specific sPLA2-receptor, and also on the ..
  6. pmc Occupational exposure to the risk of HIV infection among health care workers in Mwanza Region, United Republic of Tanzania
    B Gumodoka
    Bugando Medical Centre, Mwanza, United Republic of Tanzania
    Bull World Health Organ 75:133-40. 1997
    ..virus (HIV) transmission, availability of equipment, protective practices and the occurrence of prick and splash incidents in nine hospitals in the Mwanza Region in the north-west of the United Republic of Tanzania...
  7. ncbi Effect of crotapotin and heparin on the rat paw oedema induced by different secretory phospholipases A2
    E C Landucci
    Department of Pharmacology, Faculty of Medical Sciences, UNICAMP, Campinas, SP, Brazil
    Toxicon 38:199-208. 2000
    ..Rat paw oedema was induced by a single subplantar injection of the sPLA2s (5-30 microg/paw) in absence and presence of either crotapotin (10-100 microg/paw) or heparin (50 U/paw)...
  8. pmc Patient characteristics, diagnosis, and treatment of non-contact lens related Acanthamoeba keratitis
    S Sharma
    Jhaveri Microbiology Centre, LV Prasad Eye Institute, LV Prasad Marg, Banjara Hills, Hyderabad 500 034, India
    Br J Ophthalmol 84:1103-8. 2000
    ..To review the clinical characteristics, diagnosis, and visual outcome in patients with non-contact lens related Acanthamoeba keratitis and compare the findings with reported series of contact lens associated Acanthamoeba keratitis...
  9. ncbi Risk for eye splash injury during administration of intraocular injections: a study of retina specialists and fellows
    Dan H Bourla
    Jules Stein Eye Institute, Department of Ophthalmology, David Geffen School of Medicine, University of California Los Angeles, 200 Stein Plaza, Los Angeles, CA 90095, USA
    Retina 27:609-12. 2007
    To evaluate the use of eye protection and frequency of eye splash events during intraocular injections as well as infection risk awareness among retina specialists and fellows in training.
  10. ncbi [Lightning injuries: case report of a 17-year-old man and a brief review of the literature]
    N Stutz
    Abteilung für Plastische, Hand und Wiederherstellungschirurgie, Zentrum für Schwerbrandverletzte, Klinikum Nürnberg Süd, Breslauerstrasse 201, 90471 Nürnberg
    Unfallchirurg 109:495-8. 2006
    ..We postulate that the mechanism by which lightning caused injury to this patient was a flash discharge (side splash)...
  11. doi Effect of umbelliferone (7-hydroxycoumarin, 7-HOC) on the enzymatic, edematogenic and necrotic activities of secretory phospholipase A2 (sPLA2) isolated from Crotalus durissus collilineatus venom
    D O Toyama
    Centro de Cidncias Biológicas e da Saúde, Univesidade Mackenzie, Sao Paulo, Brazil
    Toxicon 53:417-26. 2009
    ..two-dimensional electrophoresis indicated an evident difference between HPLC-purified native and 7-HOC-treated sPLA2s, which were used in pharmacological experiments to compare their biological activities...
  12. ncbi Variations of well water radon in Virginia and Maryland
    D G Mose
    Department of Chemistry, George Mason University, VA 22030, USA
    J Environ Sci Health A Tox Hazard Subst Environ Eng 36:1647-60. 2001
    ..Aeration experiments on well water in storage tanks indicated that about 60-70% can be removed using a splash box with an exhaust fan on the storage tank, and about 60-70% can be removed using bubble aeration...
  13. ncbi Human neutrophil migration in vitro induced by secretory phospholipases A2: a role for cell surface glycosaminoglycans
    Alessandra Gambero
    Department of Pharmacology, Faculty of Medical Sciences, UNICAMP, PO Box 6111, 13081 970, Campinas, SP, Brazil
    Biochem Pharmacol 63:65-72. 2002
    ..bothropstoxin-II, and piratoxin-I), and type III- (Apis mellifera venom) secretory phospholipases A2 (sPLA2s) to induce human neutrophil chemotaxis, and the role of the cell surface proteoglycans, leukotriene B4 (LTB4), and ..
  14. ncbi Cross-talk between cytosolic phospholipase A2 alpha (cPLA2 alpha) and secretory phospholipase A2 (sPLA2) in hydrogen peroxide-induced arachidonic acid release in murine mesangial cells: sPLA2 regulates cPLA2 alpha activity that is responsible for arachido
    Won K Han
    Medical Services, Massachusetts General Hospital, Department of Medicine and Anesthesia, Harvard Medical School, Massachusetts, USA
    J Biol Chem 278:24153-63. 2003
    ..We investigated the cross-talk between group IValpha cytosolic PLA2 (cPLA2alpha) and secretory PLA2s (sPLA2s) during H2O2-induced arachidonic acid (AA) release using two types of murine MC: (i)...
  15. ncbi Use of terminal tap water filter systems for prevention of nosocomial legionellosis
    R P Vonberg
    Division of Hospital Epidemiology and Infection Control, Institute for Medical Microbiology and Hospital Epidemiology, Medical School Hannover, Carl Neuberg Str 1, D 30625 Hannover, Germany
    J Hosp Infect 60:159-62. 2005
    ..Therefore, pathogen-free water should be provided for such high-risk patients. Surveillance of splash water was performed in high-risk patient care areas at Berlin Charité-University Medicine (506 samples) and ..
  16. ncbi Mouse group X secretory phospholipase A2 induces a potent release of arachidonic acid from spleen cells and acts as a ligand for the phospholipase A2 receptor
    Y Morioka
    Shionogi Research Laboratories, Shionogi and Co, Ltd, Osaka, Japan
    Arch Biochem Biophys 381:31-42. 2000
    ..release of arachidonic acid with significant production of prostaglandin E2 more efficiently than group IB and IIA sPLA2s. In addition, sPLA2-X was identified as a high-affinity ligand for both native and recombinant form of mouse PLA2 ..
  17. pmc Formation of multilayered photosynthetic biofilms in an alkaline thermal spring in Yellowstone National Park, Wyoming
    Sarah M Boomer
    Western Oregon University, Department of Biology, Monmouth, Oregon 97361, USA
    Appl Environ Microbiol 75:2464-75. 2009
    ..used as a substratum to promote the development of biofilms that resembled multilayered mat communities in the splash zone at the geyser's source...
  18. doi Needlestick and other potential blood and body fluid exposures among health care workers in British Columbia, Canada
    Hasanat Alamgir
    Statistics and Evaluation Department, Occupational Health and Safety Agency for Healthcare, Vancouver, British Columbia, Canada
    Am J Infect Control 36:12-21. 2008
    ..Health care workers have high risk of exposure to human blood and body fluids (BBF) from patients in acute care and residents in nursing homes or personal homes...
  19. ncbi Should eye protection be worn during dermatological surgery: prospective observational study
    A J Birnie
    Department of Dermatology, Queen s Medical Centre, Nottingham, UK
    Br J Dermatol 156:1258-62. 2007
    There is a potential risk of infection with blood-borne viruses if a doctor receives a blood splash to a mucous membrane...
  20. ncbi Runoff and leaching of atrazine and alachlor on a sandy soil as affected by application in sprinkler irrigation
    A R Abdel Rahman
    Plant Protection Department, Desert Research Center, Mataria, Cairo, Egypt
    J Environ Sci Health B 34:381-96. 1999
    ..The design of the boxes allowed a measurement of pesticide concentrations in splash water throughout the rainfall event. Initial atrazine concentrations exceeding its' solubility were observed...
  21. pmc Group III secreted phospholipase A2 transgenic mice spontaneously develop inflammation
    Hiroyasu Sato
    Department of Biological Sciences, Graduate School of Humanities and Sciences, Ochanomizu University, 2 1 1 Ohtsuka, Bunkyo ku, Tokyo 112 8610, Japan
    Biochem J 421:17-27. 2009
    ..III is an atypical sPLA2 (secretory PLA2) that is homologous with bee venom PLA2 rather than with other mammalian sPLA2s. In the present paper, we show that endogenous group III sPLA2 (PLA2G3) is expressed in mouse skin and that Tg (..
  22. pmc Blood and body fluid splashes during surgery--the need for eye protection and masks
    C G Davies
    Department of Surgery, Salisbury District Hospital, Salisbury, UK
    Ann R Coll Surg Engl 89:770-2. 2007
    ..injury, some can pay little attention to reduce the potential route of infection occurring when body fluids splash into the eye. It has been shown that transmission of HIV, hepatitis B or C can occur across any mucous membrane...
  23. ncbi The status of occupational safety among health service providers in hospitals in Tanzania
    S V Manyele
    Department of Chemical and Process Engineering, College of Engineering and Technology, University ofDar es Salaam, PO Box 35131, Dar es Salaam, Tanzania
    Tanzan J Health Res 10:159-65. 2008
    ..Needlestick injuries accounted for the largest part of the most common accidents (52.9%); followed by splash of blood from patients (21.7%); burn injury from chemicals (10.6%); and slippery floors (5.9%)...
  24. ncbi Neuropathogenesis of herpesvirus papio 2 in mice parallels infection with Cercopithecine herpesvirus 1 (B virus) in humans
    Kristin M Rogers
    Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, 250 McElroy Hall, Stillwater, OK 74078 2007, USA
    J Gen Virol 87:267-76. 2006
    ..was consistently neurovirulent when administered by epidermal scarification, intracranial inoculation and an eye splash. Quantitative real-time PCR, histopathology and immunohistochemistry were used to follow the temporal spread of ..
  25. ncbi Blood splash from different diathermy instruments during tonsillectomy
    B C Hanna
    Department of ENT, Antrim Area Hospital, Antrim, Northern Ireland, UK
    J Laryngol Otol 120:927-31. 2006
    ..To compare the potential risk of blood contamination of the surgeon's conjunctiva during tonsillectomy using disposable bipolar diathermy and reusable monopolar diathermy...
  26. doi Blood exposure risk during procedural dermatology
    Ruth D Holzmann
    Department of Dermatology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Acad Dermatol 58:817-25. 2008
    ..Dermatologists are at risk of body-fluid contamination during procedures...
  27. doi Geographic variation of persistent organic pollutant levels in humpback whale (Megaptera novaeangliae) feeding areas of the North Pacific and North Atlantic
    Cristiane T Elfes
    Washington Cooperative Fish and Wildlife Research Unit, School of Aquatic and Fishery Sciences, University of Washington, 1122 NE Boat Street, Box 355020, Seattle, Washington 98195, USA
    Environ Toxicol Chem 29:824-34. 2010
    ..Biopsy blubber samples from male individuals (n = 67) were collected through SPLASH, a multinational research project, in eight North Pacific feeding grounds...
  28. ncbi Methods for determining the barrier efficacy of surgical gowns
    E A McCullough
    Institute for Environmental Research, Kansas State University, Manhattan 66506
    Am J Infect Control 21:368-74. 1993
    ..of laundering and sterilizing on the barrier efficacy of reusable gowns by means of the Impact Penetration (splash) Test, the Synthetic Blood Resistance Test, the Viral Resistance Test, and the Elbow Lean (demonstration) Test...
  29. ncbi Occupational exposures to blood in a dental teaching environment: results of a ten-year surveillance study
    F S Younai
    Section of Oral Biology and Medicine, University of California, Los Angeles School of Dentistry, 90095 1668, USA
    J Dent Educ 65:436-48. 2001
    ..Of these, 494 (98 percent) were percutaneous, and 10 (2 percent) were mucosal, each involving a splash to the eye of the dental care worker (DCW). Among the 504 exposures, 414 (82...
  30. doi Effects of Marapuama in the chronic mild stress model: further indication of antidepressant properties
    Angelo L Piato
    Laboratorio de Etnofarmacologia, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Avenida Sarmento Leite 500 202, Porto Alegre, RS 90050 170, Brazil
    J Ethnopharmacol 118:300-4. 2008
    ..Suggestive of antidepressant activity, we have established that a specific PO ethanol extract (POEE) significantly decreases immobility in the tail suspension and forced swimming tests...
  31. ncbi [Procedure in case of exposure of hospital's workers to HBV, HCV and HIV]
    Maciej Dancewicz
    Katedra i Klinika Chirurgii Klatki Piersiowej i Nowotworów Collegium Medicum im L Rydygiera w Bydgoszczy Uniwersytetu Mikołaja Kopernika w Toruniu
    Przegl Epidemiol 59:671-7. 2005
    ..blood collection or injections (34 cases), as a result of a scalpel or other surgical instrument cut (2 cases), a splash of infectious material on the skin and conjunctivae (4 cases) and in the singular cases as a result of a bite by a ..
  32. pmc Do modern spectacles endanger surgeons? The Waikato Eye Protection Study
    Simon J Chong
    Department of Plastic and Reconstructive Surgery, Waikato Hospital, Hamilton, New Zealand
    Ann Surg 245:495-501. 2007
    ..Modern fashion spectacles, being of increasingly slim design, may no longer be adequate in this role...
  33. ncbi The functions of five distinct mammalian phospholipase A2S in regulating arachidonic acid release. Type IIa and type V secretory phospholipase A2S are functionally redundant and act in concert with cytosolic phospholipase A2
    M Murakami
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142, Japan
    J Biol Chem 273:14411-23. 1998
    ..of five distinct mammalian phospholipase A2 (PLA2) enzymes (cytosolic PLA2 (cPLA2; type IV), secretory PLA2s (sPLA2s; types IIA, V, and IIC), and Ca2+-independent PLA2 (iPLA2; type VI)) to arachidonic acid (AA) metabolism by ..
  34. ncbi [Safety issues of chemo drug administration handling by nurses from an occupational exposure viewpoint-through visualization with contrast media for ophthalmic vasculature]
    Kentaro Terui
    Department of Nursing, Iwamizawa Municipal General Hospital
    Gan To Kagaku Ryoho 37:1931-5. 2010
    ..The result showed spills all over in the procedures by nurses in the study: specifically splash to environment around the drug preparation area, contamination of needles which were used for drug preparations, ..
  35. ncbi Potentiation of tumor necrosis factor alpha-induced secreted phospholipase A2 (sPLA2)-IIA expression in mesangial cells by an autocrine loop involving sPLA2 and peroxisome proliferator-activated receptor alpha activation
    Sabine Beck
    Center of Pharmacology, University Hospital Frankfurt, 60590 Frankfurt, Germany
    J Biol Chem 278:29799-812. 2003
    In rat mesangial cells, exogenously added secreted phospholipases A2 (sPLA2s) potentiate the expression of pro-inflammatory sPLA2-IIA first induced by cytokines like tumor necrosis factor-alpha (TNFalpha) and interleukin-1 beta...
  36. ncbi The risk of eye splash injuries in surgery
    S Marasco
    Alfred Hospital, Prahran, Victoria, Australia
    Aust N Z J Surg 68:785-7. 1998
    This study arose out of a concern about the transmission of infectious diseases through eye splash injuries in surgery. The purpose of this study was to identify the extent of the risk of eye splash injuries.
  37. ncbi NEW FRONTIERS IN THE STUDY OF DISPERSAL AND SPATIAL ANALYSIS OF EPIDEMICS CAUSED BY SPECIES IN THE GENUS PHYTOPHTHORA
    Jean Beagle Ristaino
    Department of Plant Pathology, North Carolina State University, Raleigh, North Carolina 27695 E mail
    Annu Rev Phytopathol 38:541-576. 2000
    ..Species of Phytophthora can be dispersed either in soil, via surface water movement down rows, from rain splash dispersal, by air, or via movement by humans or invertebrate activity...
  38. pmc Microbial composition of near-boiling silica-depositing thermal springs throughout Yellowstone National Park
    Carrine E Blank
    Department of Plant and Microbial Biology, University of California, Berkeley, California 94720, USA
    Appl Environ Microbiol 68:5123-35. 2002
    ..Within the same spring, communities in the subaqueous environment were not appreciably different than those in the splash zone at the edge of the pool, although a greater number of phylotypes was found along the pool's edge...
  39. ncbi HIV: awareness of management of occupational exposure in health care workers
    N Wig
    Department of Medicine, AIIMS, New Delhi 110 029
    Indian J Med Sci 57:192-8. 2003
    ..The present study was conducted to know the present knowledge regarding occupational exposure to HIV amongst doctors in non-governmental hospitals and clinics across Delhi...
  40. ncbi Reusable terminal tap water filters for nosocomial legionellosis prevention
    Ralf Peter Vonberg
    Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625, Hannover, Germany
    Ann Hematol 84:403-5. 2005
    ..with reusable water filters, a surveillance of splash water samples was performed. After determining the burden of Legionella spp...
  41. ncbi Preventing sharps, splash, and needlestick injuries in dentistry: a comprehensive overview
    John S Mamoun
    Gen Dent 53:188-93. 2005
    This article presents a comprehensive collection of precautions and suggestions for preventing sharps, splash, and needlestick injuries in dentistry...
  42. ncbi Diverse cellular localizations of secretory phospholipase A2 enzymes in several human tissues
    Seiko Masuda
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Biochim Biophys Acta 1736:200-10. 2005
    ..In this study, we examined by immunohistochemistry the localization of six sPLA2s (IIA, IID, IIE, IIF, V and X) in human heart, kidney, liver and stomach...
  43. ncbi Inhibition of secreted phospholipase A2. 4-glycerol derivatives of 4,5-dihydro-3-(4-tetradecyloxybenzyl)-1,2,4-4H-oxadiazol-5-one with broad activities
    Mohamed Touaibia
    Unité de Pharmacochimie Moléculaire et Systèmes Membranaires EA2381, Université Paris7 Denis Diderot, Case 7066, 2 place Jussieu, 75251 Paris, Cedex 05, France
    J Med Chem 50:1618-26. 2007
    Secreted phospholipases A2 (sPLA2s) have been reported to play an important role in various inflammatory conditions and thus represent an attractive therapeutic target...
  44. ncbi Liquid drop splashing on smooth, rough, and textured surfaces
    Lei Xu
    The James Franck Institute and Department of Physics, The University of Chicago, Chicago, Illinois 60637, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 75:056316. 2007
    ..We report experimental studies of how the splash depends on the roughness and the texture of the surfaces as well as the viscosity of the liquid...
  45. ncbi Diphoterine chemical splash decontamination solution: skin sensitization study in the guinea pig
    Laurence Mathieu
    Laboratoire PREVOR, Moulin de Verville, Valmondois, France
    Cutan Ocul Toxicol 26:181-7. 2007
    Diphoterine is an active eye/skin chemical splash decontamination solution...
  46. ncbi [Oxidative stress in victims with heavy combined cranium-facial trauma]
    A M Zakharov
    Stomatologiia (Mosk) 86:50-2. 2007
    ..Non-adequate functioning of the system of antioxidant defense on the background of free radical activity splash can be considered as breakdown of the process of adaptive reaction forming...
  47. doi Antidepressant-like effect of asiaticoside in mice
    Xin Liang
    Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, PR China
    Pharmacol Biochem Behav 89:444-9. 2008
    ..study, the potential antidepressant properties of asiaticoside were investigated in male mice in three tests -- splash test in the unpredictable chronic mild stress (CMS) model, tail suspension test (TST), forced swimming test (FST) -..
  48. doi Biochemistry and physiology of mammalian secreted phospholipases A2
    Gerard Lambeau
    Institut de Pharmacologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Universite de Nice Sophia Antipolis, 06560 Valbonne, France
    Annu Rev Biochem 77:495-520. 2008
    ..The mammalian genome contains 10 enzymatically active secreted PLA2s (sPLA2s) and two sPLA2-related proteins devoid of lipolytic enzymatic activity...
  49. pmc Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2
    Rob C Oslund
    Departments of Chemistry and Biochemistry, University of Washington, Seattle, Washington 98195, USA
    J Med Chem 51:4708-14. 2008
    We report a series of inhibitors of secreted phospholipases A2 (sPLA2s) based on substituted indoles, 6,7-benzoindoles, and indolizines derived from LY315920, a well-known indole-based sPLA2 inhibitor...
  50. ncbi The risks of splash injury when using power tools during orthopaedic surgery: a prospective study
    Asef Alani
    Department of Trauma, Leicester Royal Infirmary, Infirmary Square, Leicester, Leicestershire, LE1 5WW, United Kingdom
    Acta Orthop Belg 74:678-82. 2008
    ..the use of power tools increases spraying of bodily fluid, hence resulting in an increased risk of infectious splash injury to the face. This prospective study involved 25 patients...
  51. ncbi Sonographic findings of superior mesenteric artery syndrome causing massive gastric dilatation in a young healthy girl
    F M Abu-Zidan
    Department of Surgery, United Arab Emirates University, Al Ain, United Arab Emirates
    Singapore Med J 51:e184-6. 2010
    ..She was nauseated but was unable to vomit. Succussion splash was positive...
  52. doi Umbelliferone induces changes in the structure and pharmacological activities of Bn IV, a phospholipase A(2) isoform isolated from Bothrops neuwiedi
    Daniela de Oliveira Toyama
    Centro de Ciencias Biologicas e da Saude, Universidade Presbiteriana Mackenzie, Sao Paulo, Brazil
    Toxicon 57:851-60. 2011
    ..The amino acid sequence of Bn IV showed high sequence similarities with other Lys49 sPLA2s from B. jararacussu (BthTx-I), B. pirajai (PrTx-I), and B. neuwiedi pauloensis (Bn SP6 and Bn SP7)...
  53. pmc Splash: a software tool for stereotactic planning of recording chamber placement and electrode trajectories
    Daniel J Sperka
    Center for Neuroscience, University of California Davis, CA, USA
    Front Neuroinform 5:1. 2011
    ..Here we present SPLASh (Stereotactic PLAnning Software), an interactive software tool for the stereotactic planning of recording chamber ..
  54. pmc Splash!: a prospective birth cohort study of the impact of environmental, social and family-level influences on child oral health and obesity related risk factors and outcomes
    Andrea M de Silva-Sanigorski
    McCaughey Centre, Melbourne School of Population Health, The University of Melbourne, Carlton Australia
    BMC Public Health 11:505. 2011
    ..This study aims to prospectively examine the impact of drink choices on child obesity risk and oral health status...
  55. doi Co-firing of eucalyptus bark and rubberwood sawdust in a swirling fluidized-bed combustor using an axial flow swirler
    Songpol Chakritthakul
    School of Manufacturing Systems and Mechanical Engineering, Sirindhorn International Institute of Technology, Thammasat University, P O Box 22, Thammasat Rangsit Post Office, Pathum Thani 12121, Thailand
    Bioresour Technol 102:8268-78. 2011
    ..80% for each fuel option via variation of primary air, while secondary air was injected tangentially into the bed splash zone at a constant flowrate...
  56. doi Study of the coalescence/splash threshold of droplet impact on liquid films and its relevance in assessing airborne particle release
    C Motzkus
    Laboratoire national de métrologie et d essais LNE National Metrology Institute and Testing Laboratory, Chemistry and Biology Division, Air Quality and Gaz Flowmetering Department, 1 rue Gaston Boissier, 75724 Paris Cedex 15, France
    J Colloid Interface Sci 362:540-52. 2011
    ..particle emission during the impact of droplets on a liquid film and to assess the use of coalescence/splash relations to predict airborne particle release...
  57. doi Poor compliance with standard precautions against infections during minor gynaecological procedures
    Dushyant Maharaj
    Obstetrics and Gynaecology, Wellington School of Medicine, University of Otago, Wellington South, New Zealand
    Aust N Z J Obstet Gynaecol 52:262-5. 2012
    b>Splash injuries occurring during minor surgical procedures are associated with a significant infective risk to the operator. It is a common misconception that minor operations carry low risks.
  58. doi Visual optics: Accommodation in a splash
    Thomas W Cronin
    Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, MA 21250, USA
    Curr Biol 22:R871-3. 2012
    ..Gannets are large seabirds that hunt fish from the air, making a plunge dive followed by active swimming pursuit of prey. A recent study shows that they convert from aerial to aquatic vision nearly instantly...
  59. pmc Wilkie's syndrome: an uncommon cause of intestinal obstruction
    Prosanta Kumar Bhattacharjee
    Deptartment of Surgery, I P G M E and R S S K M Hospital, Kolkata, 700 020 West Bengal India
    Indian J Surg 70:83-5. 2008
    ..On examination the child was undernourished, had epigastric fullness and succusion splash was positive...
  60. pmc Occupational exposure to blood and body fluids in a department of oral sciences: results of a thirteen-year surveillance study
    M R A Gatto
    School of Dental Hygiene, Alma Mater Studiorum University of Bologna, 40125 Bologna, Italy
    ScientificWorldJournal 2013:459281. 2013
    ..Aim of this analysis was to identify trends that will aid in the prevention of injury...
  61. doi Nrf2 participates in depressive disorders through an anti-inflammatory mechanism
    María Dolores Martín-de-Saavedra
    Instituto Teofilo Hernando, Facultad de Medicina, Universidad Autonoma de Madrid, Madrid, Spain Departamento de Farmacología y Terapéutica, Facultad de Medicina, Universidad Autonoma de Madrid, Madrid, Spain
    Psychoneuroendocrinology 38:2010-22. 2013
    ..as an increase in the immobility time in the tail-suspension test and by a decrease in the grooming time in the splash test, (ii) reduced levels of dopamine and serotonin and increased levels of glutamate in the prefrontal cortex, (..
  62. doi Nonbactericidal secreted phospholipase A2s are potential anti-inflammatory factors in the mammary gland
    Eyal Seroussi
    Institute of Animal Science, ARO, The Volcani Center, P O Box 6, Beit Dagan, 50250, Israel
    Immunogenetics 65:861-71. 2013
    The recent burst of duplication and divergence of the bovine PLA2G2D genes is considered typical of immune response genes, and it was recently shown that PLA2G2D is abundantly expressed in mouse leukocytes and acts as an ..
  63. doi The role of secretory phospholipase A₂ in the central nervous system and neurological diseases
    Tatsurou Yagami
    Division of Physiology, Faculty of Pharmaceutical Sciences, Himeji Dokkyo University, 2 1 7, Kami ohno, Himeji, Hyogo, 670 8524, Japan
    Mol Neurobiol 49:863-76. 2014
    Secretory phospholipase A2 (sPLA2s) are small secreted proteins (14-18 kDa) and require submillimolar levels of Ca(2+) for liberating arachidonic acid from cell membrane lipids...
  64. doi A facile assay to monitor secretory phospholipase A₂ using 8-anilino-1-naphthalenesulfonic acid
    Hamse K Vivek
    Department of Biotechnology, Sri Jayachamarajendra College of Engineering, Mysore 570006, India
    Anal Biochem 461:27-35. 2014
    Secretory phospholipases A2 (sPLA2s) are present in snake venoms, serum, and biological fluids of patients with various inflammatory, autoimmune and allergic disorders...
  65. doi Judging complex movement performances for excellence: a principal components analysis-based technique applied to competitive diving
    Cole Young
    Department of Mechanical and Aerospace Engineering, University of California at Irvine, United States Electronic address
    Hum Mov Sci 36:107-22. 2014
    ..their temporal weighting coefficients, as well as elements commonly assumed to affect scoring - gross body path, splash area, and board tip motion - to identify eigendives...
  66. pmc Effects of crop canopies on rain splash detachment
    Bo Ma
    State Key Laboratory of Soil Erosion and Dryland Farming on Loess Plateau, Institute of Soil and Water Conservation, Northwest A and F University, Yangling, Shaanxi Province, China College of Resources and Environment, Northwest A and F University, Yangling, Shaanxi Province, China
    PLoS ONE 9:e99717. 2014
    Crops are one of the main factors affecting soil erosion in sloping fields. To determine the characteristics of splash erosion under crop canopies, corn, soybean, millet, and winter wheat were collected, and the relationship among splash ..
  67. doi Impact height and wall distance in bloodstain pattern analysis--what patterns of round bloodstains can tell us
    M Kettner
    Department of Experimental Forensic Medicine, Institute of Forensic Medicine, Saarland University Medical School, Homburg Saar, Germany
    Int J Legal Med 129:133-40. 2015
    ..a result of different fractions of blood that were projected in a garland or crown-like form of a "Worthington splash" after impact...
  68. pmc Artificial tektites: an experimental technique for capturing the shapes of spinning drops
    Kyle A Baldwin
    School of Physics and Astronomy, University of Nottingham, Nottingham, NG7 2RD, UK
    Sci Rep 5:7660. 2015
    ..The wax models resemble splash-form tektites, glassy stones formed from molten rock ejected from asteroid impacts...
  69. doi Blockade of NMDA receptors reverses the depressant, but not anxiogenic effect of adolescence social isolation in mice
    Arya Haj-Mirzaian
    Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    Eur J Pharmacol 750:160-6. 2015
    ..decreased the immobility time in the forced swimming test as well as an increase in grooming behavior in splash test...
  70. doi Seeing liquids from static snapshots
    Vivian C Paulun
    Department of Experimental Psychology, University of Gießen, Germany Electronic address
    Vision Res 115:163-74. 2015
    ..Here, however, we show that shape also provides powerful visual cues to material properties. When liquids pour, splash or ooze, they organize themselves into characteristic shapes, which are highly diagnostic of the material's ..
  71. pmc Critical role of phospholipase A2 group IID in age-related susceptibility to severe acute respiratory syndrome-CoV infection
    Rahul Vijay
    Interdisciplinary Program in Immunology and Department of Otolaryngology, Department of Pathology, and Department of Microbiology, University of Iowa, Iowa City, IA 52242
    J Exp Med 212:1851-68. 2015
    ..Here, we show that age-dependent increases of one such factor in the lungs, a phospholipase A2 (PLA2) group IID (PLA2G2D) with antiinflammatory properties, contributed to worse outcomes in mice infected with severe acute respiratory ..
  72. pmc Population Variation in the Life History of a Land Fish, Alticus arnoldorum, and the Effects of Predation and Density
    Edward R M Platt
    Evolution and Ecology Research Centre, and the School of Biological, Earth and Environmental Sciences, University of New South Wales, Kensington NSW 2052, Australia
    PLoS ONE 10:e0137244. 2015
    ..This fish from the island of Guam spends its adult life out of the water on rocks in the splash zone, where it is vulnerable to predation and can be expected to be sensitive to changes in population density ..
  73. doi CNS myelin structural modification induced in vitro by phospholipases A2
    Pablo J Yunes Quartino
    Departamento de Química Biológica CIQUIBIC CONICET, Facultad de Ciencias Quimicas, Universidad de Nacional de Córdoba, Haya de la Torre S N, X5000HUA, Cordoba, Argentina
    Biochim Biophys Acta 1858:123-9. 2016
    ..It was observed that myelin treated with all the tested sPLA2s (from cobra and bee venoms and from pig pancreas) preserved the lamellar structure but displayed an enlarged ..
  74. doi Droplet impact on deep liquid pools: Rayleigh jet to formation of secondary droplets
    Eduardo Castillo-Orozco
    Department of Mechanical and Aerospace Engineering, University of Central Florida, Orlando, Florida 32816, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 92:053022. 2015
    ..Ohnesorge number (Oh) and impact Weber number (We), a regime map for no breakup, Rayleigh jet breakup, and crown splash is suggested...
  75. doi Involvement of D1 and D2 dopamine receptors in the antidepressant-like effects of selegiline in maternal separation model of mouse
    Shayan Amiri
    Regenerative Medicine Program, Department of Biochemistry and Medical Genetics, College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    Physiol Behav 163:107-14. 2016
    ..2-14 followed by behavioral tests for determining depressive-like behaviors, such as forced swimming test (FST), splash test and sucrose preference test (SPT) in adult mice (PND 50)...
  76. doi The upside-down water collection system of Syntrichia caninervis
    Zhao Pan
    Department of Mechanical Engineering, Brigham Young University, 435 CTB, Provo, Utah 84602, USA
    Nat Plants 2:16076. 2016
    ..and films on the leaf hair from humid atmospheres; collection of fog droplets on leaf hairs; collection of splash water from raindrops; and transportation of the acquired water to the leaf itself...
  77. pmc Sound Wave Energy Resulting from the Impact of Water Drops on the Soil Surface
    Magdalena Ryżak
    Institute of Agrophysics, Polish Academy of Sciences, Doswiadczalna 4, 20 290 Lublin, Poland
    PLoS ONE 11:e0158472. 2016
    ..Here, we present a new aspect of the splash phenomenon's characterization the measurement of the sound pressure level and the sound energy of the wave that ..
  78. doi Antidepressant-like effect of pramipexole in an inflammatory model of depression
    Vicente Lieberknecht
    Department of Biochemistry, Center of Biological Sciences, Federal University of Santa Catarina, 88040 900, Florianopolis, SC, Brazil
    Behav Brain Res 320:365-373. 2017
    ..1mg/kg, i.p.) in the forced swim test, and the anhedonic behavior in the splash test...
  79. doi Management of Upper Extremity Injury in Divers
    Steven C Haase
    Department of Surgery, University of Michigan Health System, Ann Arbor, MI, USA Department of Orthopaedic Surgery, University of Michigan Health System, Ann Arbor, MI, USA Electronic address
    Hand Clin 33:73-80. 2017
    ..Hand positions that minimize the amount of splash result in forceful wrist extension...
  80. ncbi Splish splash... Adding alcohol-based handrubs to hand hygiene routines contributes to patient safety, saves lives and adds to operational efficiency
    Janice Olson
    Contemp Longterm Care 27:34-5. 2004
  81. pmc Inbreeding depression in urban environments of the bird's nest fungus Cyathus stercoreus (Nidulariaceae: Basidiomycota)
    B D Malloure
    Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Heredity (Edinb) 110:355-62. 2013
    ..dispersal and inbreeding in the bird's nest fungus Cyathus stercoreus, a dung and mulch-associated fungus with a splash cup fruiting body appearing like a miniature bird's nest of 'eggs' or peridioles that contain thousands of mating ..
  82. pmc Assessing phospholipase A2 activity toward cardiolipin by mass spectrometry
    Yuan Hao Hsu
    Department of Chemistry, Tunghai University, Taichung, Taiwan
    PLoS ONE 8:e59267. 2013
    ..The sPLA2s caused an accumulation of dilyso-cardiolipin, in contrast to iPLA2 which caused an accumulation of monolyso-..
  83. doi Laboratory evaluation of thermal protective clothing performance upon hot liquid splash
    Farzan Gholamreza
    Human Ecology Department, University of Alberta, Human Ecology Building, Edmonton, Alberta T6G 2N1, Canada
    Ann Occup Hyg 57:805-22. 2013
    This study provides an understanding of heat and mass transfer through materials exposed to hot liquid splash, a relatively unexplored hazard in the safety clothing industry...
  84. ncbi Effect of Cherenkov radiation on the jitter of solitons in the driven underdamped Frenkel-Kontorova model
    I I Soloviev
    Skobeltsyn Institute of Nuclear Physics, Moscow State University, Moscow 119991, Russia
    Phys Rev E Stat Nonlin Soft Matter Phys 87:060901. 2013
    ..In contrast to the continuous case, we have observed a dramatic splash of the jitter...
  85. ncbi Impact of granular drops
    J O Marston
    Division of Physical Sciences and Engineering, King Abdullah University of Science and Technology, Thuwal 23955 6900, Saudi Arabia
    Phys Rev E Stat Nonlin Soft Matter Phys 88:010201. 2013
    ..The speeds of the grains ejected during the "splash" are measured and they rarely exceed twice that of the impact speed.
  86. pmc Secreted phospholipases A2 of snake venoms: effects on the peripheral neuromuscular system with comments on the role of phospholipases A2 in disorders of the CNS and their uses in industry
    John B Harris
    Medical Toxicology Centre and Institute of Neurosciences, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
    Toxins (Basel) 5:2533-71. 2013
    ..This review provides an introduction to the biochemical properties of secreted sPLA2s in the venoms of many dangerous snakes and a detailed discussion of their role in the initiation of the ..
  87. ncbi Laboratory evaluation of a potential diesel fuel interference in the determination of polycyclic aromatic compounds on dermal samplers
    Robert A Weker
    Harvard School of Public Health, Department of Environmental Health, Boston, Massachusetts 02115, USA
    J Occup Environ Hyg 1:334-42. 2004
    ..Diesel fuel used for cleaning can splash onto the dermal sampler...
  88. ncbi Basic amino acid residues in the beta-structure region contribute, but not critically, to presynaptic neurotoxicity of ammodytoxin A
    Gabriela Ivanovski
    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Jamova 39, SI 1000 Ljubljana, Slovenia
    Biochim Biophys Acta 1702:217-25. 2004
    The molecular mechanism of action of presynaptically toxic secreted phospholipases A2 (sPLA2s) isolated from snake venoms is not completely understood...
  89. ncbi Effects of desipramine and tramadol in a chronic mild stress model in mice are altered by yohimbine but not by pindolol
    Ipek Yalcin
    EA 3248 Psychobiologie des Emotions, Faculte des Sciences et Techniques, Universite Francois Rabelais, Parc Grandmont F 37200 Tours, France
    Eur J Pharmacol 514:165-74. 2005
    ..mild stress regimen induced a degradation of the state of the coat and decreased the grooming behaviour in the splash test. These physical and behavioural abnormalities were counteracted by tramadol and desipramine...
  90. ncbi Diphoterine for emergent decontamination of skin/eye chemical splashes: 24 cases
    Jochen Nehles
    Mannesmann Hoesch Prazisrohr, Remscheid, Germany
    Cutan Ocul Toxicol 25:249-58. 2006
    ..There were 11 acid eye splashes, 8 acid skin splashes, 4 base eye splashes, and 1 base skin splash. Following Diphoterine decontamination, no burns developed and there were no requirements for burn treatment or ..
  91. ncbi Effect of time of day and duration into shift on hazardous exposures to biological fluids
    D J Macias
    University of New Mexico, Department of Emergency Medicine, Albuquerque, USA
    Acad Emerg Med 3:605-10. 1996
    ..To determine whether hospital employee biological hazardous exposure rates varied with time of day or increased with time interval into shift...
  92. ncbi Secreted phospholipase A2-induced neurotoxicity and epileptic seizures after intracerebral administration: an unexplained heterogeneity as emphasized with paradoxin and crotoxin
    F Dorandeu
    Department of Toxicology, Unit of Neuropharmacology, Centre de Recherches du Service de Sante des Armees, La Tronche, France
    J Neurosci Res 54:848-62. 1998
    ..The results obtained with the other enzymes showed that toxic sPLA2s can effectively be differentiated based on two criteria: the presence of cortically recorded epileptic paroxysmal ..
  93. ncbi Cloning and recombinant expression of a novel mouse-secreted phospholipase A2
    E Valentin
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS, UPR 411, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    J Biol Chem 274:19152-60. 1999
    Secreted phospholipases A2 (sPLA2s) form a class of structurally related enzymes that are involved in a variety of physiological and pathological effects including inflammation and associated diseases, cell proliferation, cell adhesion, ..
  94. ncbi Recommendations for prevention of and therapy for exposure to B virus (cercopithecine herpesvirus 1)
    Jeffrey I Cohen
    Medical Virology Section, Laboratory of Clinical Investigation, National Institutes of Health, Bethesda, Maryland 20892, USA
    Clin Infect Dis 35:1191-203. 2002
    ..inoculation with infected materials; however, the first fatal case of B virus infection due to mucosal splash exposure was reported in 1998...
  95. ncbi Cellular arachidonate-releasing function of novel classes of secretory phospholipase A2s (groups III and XII)
    Makoto Murakami
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    J Biol Chem 278:10657-67. 2003
    ..Based on the present results as well as our current analyses on the group I/II/V/X sPLA(2)s, general properties of cellular actions of a full set of mammalian sPLA(2)s in regulating AA metabolism are discussed...
  96. ncbi Secretory phospholipase A2
    Makoto Murakami
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan
    Biol Pharm Bull 27:1158-64. 2004
    ..b>sPLA2s are distributed in a wide variety of vertebrate and invertebrate animals, plants, bacteria, and viruses, and there ..
  97. ncbi Characterization of a cDNA encoding Arabidopsis secretory phospholipase A2-alpha, an enzyme that generates bioactive lysophospholipids and free fatty acids
    Stephen B Ryu
    Department of Horticulture, University of Wisconsin, 1575 Linden Drive, Madison, WI 53706, USA
    Biochim Biophys Acta 1736:144-51. 2005
    ..Different from animal sPLA2s, AtsPLA2-alpha showed a significant preference for the acyl group linoleic acid over palmitic acid in phospholipid ..
  98. ncbi Selective oviposition of the mayfly Baetis bicaudatus
    Andrea C Encalada
    Department of Entomology, Cornell University, Ithaca, NY, 14850, USA
    Oecologia 148:526-37. 2006
    ..and experiments showed that females preferred to oviposit under relatively large rocks located in places with high splash associated with fast current, which may provide visual, mechanical or both cues to females...
  99. ncbi Hand surgery on patients who are "high risk" for blood-borne viruses
    S A Al-Ani
    Department of Plastic Surgery, Castle Hill Hospital, Cottingham, UK
    J Hand Surg Br 31:426-31. 2006
    ..When possible, wounds should be closed with staples, glue or absorbable sutures. Appropriate steps must be taken to reduce the risk of injuries from sharp bone ends, K-wires and splash exposure during irrigation.
  100. ncbi Recombinant production and properties of binding of the full set of mouse secreted phospholipases A2 to the mouse M-type receptor
    Morgane Rouault
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UMR 6097, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    Biochemistry 46:1647-62. 2007
    To date, 12 secreted phospholipases A2 (sPLA2s) have been identified in the mouse species and divided into three structural collections (I/II/V/X, III, and XII)...
  101. ncbi Salmonella transmission through splash exposure during a bovine necropsy
    David A Bemis
    Department of Comparative Medicine, University of Tennessee College of Veterinary Medicine, Knoxville, Tennessee 37996, USA
    Foodborne Pathog Dis 4:387-90. 2007
    ..The isolates had indistinguishable phenotypic and genotypic characteristics. A splash exposure was the suspected means of transmission of the human infection...

Research Grants14

  1. Regulation and Function of Cytosolic Phospholipase A2
    Michael H Gelb; Fiscal Year: 2012
    ..We will also study the role of cPLA2s and secreted phospholipases A2 (sPLA2s) in lipid mediator production from human platelets stimulated with a variety of agonists...
  2. Mechanisms of abdominal aortic aneurysm formation
    Alan Daugherty; Fiscal Year: 2010
    ..Project 4 (Nancy R. Webb) will determine the role of specific isoenzymes of secretory phospholipase A2s in promoting inflammation at the site of macrophage recruitment during the evolving AAA...
  3. Teal S Hallstrand; Fiscal Year: 2016
    ..hypothesis that the airway epithelium serves as a regulator of eicosanoid production through the expression of sPLA2s. A total of 10 mammalian sPLA2s have been described...
  4. Scott J Russo; Fiscal Year: 2014
    ..the forced swim test (FST), anhedonic responses on sucrose preference tests (SPT), decreased time grooming on the splash test, increased latency to feed on novelty suppressed feeding (NSF), and increased serum corticosterone levels...
  5. Michael H Gelb; Fiscal Year: 2016
    ..by a family of enzymes called phospholipase A2, The mammalian genome encodes 10 secreted phospholipases A2 (sPLA2s), and the role of these enzymes in mediating arachidonic acid release is under active investigation...
  6. BIOCHEMICAL STUDIES OF 14 KDA PHOSPHOLIPASES A2
    Michael Gelb; Fiscal Year: 2006
    ..Mammalian cells contain two types of PLA2s that are involved in arachidonic acid production. The secreted PLA2s (sPLA2s) are 14-18 kDa, calcium-dependent enzymes that are secreted from a large number of mammalian cells following ..
  7. Multimedia Motivational Interviewing Training for Physical Therapists
    ROBIN INLANDER; Fiscal Year: 2007
    ..After its completion, the prototype will be fully functional and will include a splash screen that introduces the product and demonstrates its overall ?look and feel ?; and also a main menu that will ..
  8. SPLA2 AND SURFACTANT IN ASTHMA
    David Bass; Fiscal Year: 2003
    ..Little is known about the pulmonary distribution or functions of these potentially toxic sPLA2S. The central hypothesis of the proposal is that the five isotypes of sPLA2 will have distinct cellular ..
  9. MECHANISMS OF AIRWAY HYPERRESPONSIVENESS
    Alan Leff; Fiscal Year: 2005
    ..The final (third) aim of this proposal will examine the molecular mechanism of binding of sPLA2s to the plasma membrane...
  10. Role of Vimentin, sPLA2 and LysoPC in Autoimmune Disease
    SUZANNE BARBOUR; Fiscal Year: 2005
    ..To test this hypothesis, we will further characterize the interactions between vimentin and the sPLA2s, in particular the group V enzyme that readily hydrolyzes the zwitterionic phospholipids in the outer leaflet of ..
  11. Helicobacter pylori: Pathogenesis and Virulence
    Kenneth Simpson; Fiscal Year: 2005
    ....
  12. SURVIVAL AND DEATH OF NEURONS
    TIMOTHY CUNNINGHAM; Fiscal Year: 2003
    ..It is expected that these experiments will provide further insights into mechanisms and potential therapies for neuron degeneration after CNS injury and in nervous system diseases. ..
  13. Interaction of BMP, WNT and SHH in the Vertebrate Limb
    Juan Carlos Izpisua Belmonte; Fiscal Year: 2005
    ....
  14. Notch Signaling and Left-Right Asymmetry Determination
    Juan Carlos Izpisua Belmonte; Fiscal Year: 2007
    ..The study of the early stages of L-R determination and the identification of new genes involved in various vertebrate model organisms would undoubtedly shed new light on the genetic factors contributing to laterality defects in humans. ..