PLA2G2A

Summary

Gene Symbol: PLA2G2A
Description: phospholipase A2 group IIA
Alias: MOM1, PLA2, PLA2B, PLA2L, PLA2S, PLAS1, sPLA2, phospholipase A2, membrane associated, GIIC sPLA2, NPS-PLA2, group IIA phospholipase A2, non-pancreatic secretory phospholipase A2, phosphatidylcholine 2-acylhydrolase 2A, phospholipase A2, group IIA (platelets, synovial fluid)
Species: human

Top Publications

  1. pmc Fusion of neurotransmitter vesicles with target membrane is calcium independent in a cell-free system
    U O Karli
    Friedrich Miescher Institut, Basel, Switzerland
    Proc Natl Acad Sci U S A 87:5912-5. 1990
  2. pmc The human platelet alloantigens, PlA1 and PlA2, are associated with a leucine33/proline33 amino acid polymorphism in membrane glycoprotein IIIa, and are distinguishable by DNA typing
    P J Newman
    Blood Center of Southeastern Wisconsin, Milwaukee 53233
    J Clin Invest 83:1778-81. 1989
  3. ncbi Inhibition of phospholipase A2 (PLA2) activity by nifedipine and nisoldipine is independent of their calcium-channel-blocking activity
    J Chang
    Department of Experimental Therapeutics, Wyeth Laboratories, Inc, Philadelphia, Pennsylvania 19101
    Inflammation 11:353-64. 1987
  4. ncbi Mobile phase effects on membrane protein elution during immobilized artificial membrane chromatography
    C Pidgeon
    Department of Medicinal Chemistry, School of Pharmacy, Purdue University, West Layfayette, IN 47907, USA
    J Chromatogr A 721:213-30. 1996
  5. ncbi Decreased phospholipase A2 activity in the brain and in platelets of patients with Alzheimer's disease
    W F Gattaz
    Central Institute of Mental Health, Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 246:129-31. 1996
  6. ncbi Angiotensin II type 1-receptor antagonism prevents type IIA secretory phospholipase A2-dependent lipid peroxidation
    Maren Luchtefeld
    Abteilung Kardiologie und Angiologie, Medizinische Hochschule Hannover, D 30625 Hannover, Germany
    Atherosclerosis 194:62-70. 2007
  7. ncbi Cloning and recombinant expression of phospholipase A2 present in rheumatoid arthritic synovial fluid
    J J Seilhamer
    California Biotechnology Inc, Mt View 94043
    J Biol Chem 264:5335-8. 1989
  8. ncbi Diversity of group types, regulation, and function of phospholipase A2
    E A Dennis
    Department of Chemistry 0601, University of California, San Diego, La Jolla 92093 0601
    J Biol Chem 269:13057-60. 1994
  9. ncbi On the binding preference of human groups IIA and X phospholipases A2 for membranes with anionic phospholipids
    Sofiane Bezzine
    Department of Chemistry, University of Washington, Seattle 98195, USA
    J Biol Chem 277:48523-34. 2002
  10. ncbi Akt as a mediator of secretory phospholipase A2 receptor-involved inducible nitric oxide synthase expression
    Dae Won Park
    Department of Biochemistry and Molecular Biology, College of Medicine, Yeungnam University, 317 1 Daemyung 5 Dong, Nam Gu, Daegu 705 035, Korea
    J Immunol 170:2093-9. 2003

Research Grants

  1. ALTERED CARDIAC MYOCYTE SIGNALING IN DIABETIC MYOCARDIUM AND FUNCTIONAL SEQUELAE
    ANTHONY JUSTIN MUSLIN; Fiscal Year: 2010
  2. The Impact of Omega three Fatty Acids on Vascular Function and cIMT in HIV
    Christine A Wanke; Fiscal Year: 2013
  3. Studies of Eicosanoid Biosynthetic Proteins
    Wonhwa Cho; Fiscal Year: 2013
  4. Biology, Immunology &therapy of Acanthamoeba Keratitis
    Hassan Alizadeh; Fiscal Year: 2013
  5. Role of phospholipase A2 in spinal cord secondary injury
    Xiao Ming Xu; Fiscal Year: 2013
  6. Michael H Gelb; Fiscal Year: 2016
  7. CYTOSOLIC PHOSPHOLIPASE A2 TRANSFORMED CELLS
    Raphael Nemenoff; Fiscal Year: 2002
  8. Gadiparthi N Rao; Fiscal Year: 2015
  9. Gadiparthi N Rao; Fiscal Year: 2016
  10. Michael A Collins; Fiscal Year: 2016

Detail Information

Publications324 found, 100 shown here

  1. pmc Fusion of neurotransmitter vesicles with target membrane is calcium independent in a cell-free system
    U O Karli
    Friedrich Miescher Institut, Basel, Switzerland
    Proc Natl Acad Sci U S A 87:5912-5. 1990
    ..in vitro by using chromaffin granules (CGs) and target membrane vesicles and a Ca2(+)-dependent phospholipase A2 (PLA2). Vesicle fusion is measured by a fluorescence dequenching assay with octadecyl rhodamine B used as the marker...
  2. pmc The human platelet alloantigens, PlA1 and PlA2, are associated with a leucine33/proline33 amino acid polymorphism in membrane glycoprotein IIIa, and are distinguishable by DNA typing
    P J Newman
    Blood Center of Southeastern Wisconsin, Milwaukee 53233
    J Clin Invest 83:1778-81. 1989
    The human platelet alloantigens, PlA1 and PlA2, comprise a diallelic antigen system located on a component of the platelet fibrinogen receptor, membrane glycoprotein (GP) IIIa...
  3. ncbi Inhibition of phospholipase A2 (PLA2) activity by nifedipine and nisoldipine is independent of their calcium-channel-blocking activity
    J Chang
    Department of Experimental Therapeutics, Wyeth Laboratories, Inc, Philadelphia, Pennsylvania 19101
    Inflammation 11:353-64. 1987
    The effects of several calcium antagonists on phospholipase A2 (PLA2) activity were examined...
  4. ncbi Mobile phase effects on membrane protein elution during immobilized artificial membrane chromatography
    C Pidgeon
    Department of Medicinal Chemistry, School of Pharmacy, Purdue University, West Layfayette, IN 47907, USA
    J Chromatogr A 721:213-30. 1996
    ..Two protein mixtures containing bovine pancreatic PLA2 were used in this study...
  5. ncbi Decreased phospholipase A2 activity in the brain and in platelets of patients with Alzheimer's disease
    W F Gattaz
    Central Institute of Mental Health, Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 246:129-31. 1996
    Phospholipase A2 (PLA2) is a key enzyme in the metabolism of membrane phospholipids...
  6. ncbi Angiotensin II type 1-receptor antagonism prevents type IIA secretory phospholipase A2-dependent lipid peroxidation
    Maren Luchtefeld
    Abteilung Kardiologie und Angiologie, Medizinische Hochschule Hannover, D 30625 Hannover, Germany
    Atherosclerosis 194:62-70. 2007
    ..Secretory phospholipase A2 type IIA (sPLA2-IIA) modulates the enzymatic process of LDL-modification and was recently identified as an independent predictor ..
  7. ncbi Cloning and recombinant expression of phospholipase A2 present in rheumatoid arthritic synovial fluid
    J J Seilhamer
    California Biotechnology Inc, Mt View 94043
    J Biol Chem 264:5335-8. 1989
    ..The deduced amino acid sequence constitutes an enzyme of the "Type II" class of PLA2s, and resembles PLA2s from other mammalian sources...
  8. ncbi Diversity of group types, regulation, and function of phospholipase A2
    E A Dennis
    Department of Chemistry 0601, University of California, San Diego, La Jolla 92093 0601
    J Biol Chem 269:13057-60. 1994
  9. ncbi On the binding preference of human groups IIA and X phospholipases A2 for membranes with anionic phospholipids
    Sofiane Bezzine
    Department of Chemistry, University of Washington, Seattle 98195, USA
    J Biol Chem 277:48523-34. 2002
    ..Binding affinity of hGIIA, hGX, and their mutants to PC-rich vesicles is well correlated to the ability of these enzymes to act on the PC-rich outer plasma membrane of mammalian cells...
  10. ncbi Akt as a mediator of secretory phospholipase A2 receptor-involved inducible nitric oxide synthase expression
    Dae Won Park
    Department of Biochemistry and Molecular Biology, College of Medicine, Yeungnam University, 317 1 Daemyung 5 Dong, Nam Gu, Daegu 705 035, Korea
    J Immunol 170:2093-9. 2003
    ..These results suggest that group IIA PLA(2) induces nitrite production by involving of M-type sPLA(2)R, which then mediates signal transduction events that lead to PI3K/Akt activation...
  11. ncbi Tagging-SNP haplotype analysis of the secretory PLA2IIa gene PLA2G2A shows strong association with serum levels of sPLA2IIa: results from the UDACS study
    Peter T E Wootton
    Division of Cardiovascular Genetics, Department of Medicine, Royal Free and University College Medical School, 5 University Street, London WC1E 6JF, UK
    Hum Mol Genet 15:355-61. 2006
    ..study aimed to examine the relationship between serum levels of sPLA(2)IIa and variation in the sPLA(2)IIa gene (PLA2G2A) in a cohort of patients with Type II diabetes (T2D) mellitus...
  12. ncbi Tagging SNP haplotype analysis of the secretory PLA2-V gene, PLA2G5, shows strong association with LDL and oxLDL levels, suggesting functional distinction from sPLA2-IIA: results from the UDACS study
    Peter T E Wootton
    Division of Cardiovascular Genetics, Department of Medicine, Royal Free and University College Medical School, 5 University Street, London WC1E 6JF, UK
    Hum Mol Genet 16:1437-44. 2007
    ..suggest that both secretory PLA2 (sPLA2)-V and sPLA2-IIA (encoded, respectively, by the neighbouring PLA2G5 and PLA2G2A genes) contribute to atherogenesis...
  13. doi Inflammatory protein sPLA(2)-IIA abrogates TNFalpha-induced apoptosis in human astroglioma cells: Crucial role of ERK
    Elvira Ibeas
    Instituto de Biologia y Genetica Molecular, CSIC Universidad de Valladolid, Spain
    Biochim Biophys Acta 1793:1837-47. 2009
    ....
  14. pmc Production of vascular endothelial growth factors from human lung macrophages induced by group IIA and group X secreted phospholipases A2
    Francescopaolo Granata
    Division of Clinical Immunology and Allergy and Center for Basic and Clinical Immunology Research, University of Naples Federico II, Naples
    J Immunol 184:5232-41. 2010
    ..Thus, sPLA(2)s may play an important role in inflammatory and/or neoplastic angiogenesis and lymphangiogenesis...
  15. pmc Secreted PLA2 induces proliferation in astrocytoma through the EGF receptor: another inflammation-cancer link
    Marita Hernández
    Instituto de Biologia y Genetica Molecular, Consejo Superior de Investigaciones Cientificas Universidad de Valladolid, C Sanz y Fores s n, 47003 Valladolid, Spain
    Neuro Oncol 12:1014-23. 2010
    ..Therefore, this mechanism could contribute to worsen the prognosis of a tumor in an inflammatory microenvironment. We also present more links of the tumor chain possibly susceptible to targeting...
  16. pmc Secretory phospholipase A2-IIa is involved in prostate cancer progression and may potentially serve as a biomarker for prostate cancer
    Zhongyun Dong
    Department of Medicine, University of Cincinnati College of Medicine, 2120 East Galbraith Road, Cincinnati, OH 45237 0507, USA
    Carcinogenesis 31:1948-55. 2010
    ..Previous studies showed that secretory phospholipase A2-IIa (sPLA2-IIa) is overexpressed in almost all human prostate cancer specimens and its elevated levels are correlated with ..
  17. pmc Relationship between levels of secreted phospholipase A₂ groups IIA and X in the airways and asthma severity
    T S Hallstrand
    Department of Medicine, Divisions of Pulmonary and Critical Care, University of Washington, Seattle, WA 98195, USA
    Clin Exp Allergy 41:801-10. 2011
    ..Conclusions and Clinical Relevance These data indicate that sPLA(2) -IIA and sPLA(2) -X are the major sPLA(2) s in human airways, and suggest a link between the levels of sPLA(2) -X in the airways and several features of asthma...
  18. doi Vav3 oncogene is involved in regulation of secretory phospholipase A2-IIa expression in prostate cancer
    Zhongyun Dong
    Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Oncol Rep 25:1511-6. 2011
    Our previous study revealed that Vav3 oncogene and secretory phospholipase A2-IIa (sPLA2-IIa) are overexpressed in androgen-independent prostate cancer cells relative to their androgen-dependent counterparts and contribute to development ..
  19. pmc Secretory phospholipase A2-IIa is a target gene of the HER/HER2-elicited pathway and a potential plasma biomarker for poor prognosis of prostate cancer
    Leslie Oleksowicz
    Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Prostate 72:1140-9. 2012
    Our previous study showed that prostate cancer cells overexpress and secrete secretory phospholipases A2 group IIa (sPLA2-IIa) and plasma sPLA2-IIa was elevated in prostate cancer patients...
  20. pmc Knockdown of secretory phospholipase A2 IIa reduces lung cancer growth in vitro and in vivo
    Jessica A Yu
    Section of General Thoracic Surgery, Division of Cardiothoracic Surgery, Department of Surgery, University of Colorado School of Medicine, Aurora, CO, USA
    J Thorac Cardiovasc Surg 144:1185-91. 2012
    Group IIa secretory phospholipase A2 (sPLA2 IIa) plays a role in the malignant potential of several epithelial cancers...
  21. pmc High specificity of human secretory class II phospholipase A2 for phosphatidic acid
    Y Snitko
    Department of Chemistry, University of Illinois at Chicago, 60607 7061, USA
    Biochem J 321:737-41. 1997
    ..The phospholipase A2 (PLA2)-catalysed hydrolysis of phosphatidic acid (PA) is thought to be a primary synthetic route for LPA...
  22. ncbi Macrophage-specific expression of group IIA sPLA2 results in accelerated atherogenesis by increasing oxidative stress
    Uwe J F Tietge
    Department of Medicine, Charite Campus Mitte, Humboldt University, Berlin, Germany
    J Lipid Res 46:1604-14. 2005
    Group IIA secretory phospholipase A2 (sPLA2) is an acute-phase protein mediating decreased plasma HDL cholesterol and increased atherosclerosis...
  23. ncbi The roles of sPLA2-IIA (Pla2g2a) in cancer of the small and large intestine
    Remond J A Fijneman
    Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Front Biosci 13:4144-74. 2008
    The mouse secretory phospholipase A2 group IIA (sPLA2-IIA) gene Pla2g2a has been identified as a susceptibility gene for cancer of the small and large intestine...
  24. ncbi Molecular basis for the association of group IIA phospholipase A(2) and decorin in human atherosclerotic lesions
    P Sartipy
    Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Goteborg, Sweden
    Circ Res 86:707-14. 2000
    ..As a consequence, this active extracellular enzyme may contribute to the pathogenesis of atherosclerosis by modifying lipoproteins and releasing inflammatory lipid mediators at places of lipoprotein retention in the arterial wall...
  25. pmc Signal transduction in esophageal and LES circular muscle contraction
    K M Harnett
    Department of Medicine, Rhode Island Hospital and Brown University, Providence 02903, USA
    Yale J Biol Med 72:153-68. 1999
    ..activity of a low molecular weight (approximately 14 kDa) pancreatic-like (group 1) secreted phospholipase A2 (sPLA2) and production of arachidonic acid (AA), which is metabolized to prostaglandins and thromboxanes...
  26. pmc Inhibition of carrageenin-induced rat paw oedema by crotapotin, a polypeptide complexed with phospholipase A2
    E C Landucci
    Department of Biochemistry, UNICAMP, Campinas SP, Brazil
    Br J Pharmacol 114:578-83. 1995
    ..effect of purified crotapotin, a non-toxic non-enzymatic chaperon protein normally complexed to a phospholipase A2 (PLA2) in South America rattlesnake venom, was studied in the acute inflammatory response induced by carrageenin (1 mg/..
  27. ncbi Therapeutic time-window of a group IIA phospholipase A2 inhibitor in rabbit acute lung injury: correlation with lung surfactant protection
    S Furue
    Discovery Research Laboratories, Shionogi and Co, Ltd, Osaka, Japan
    Crit Care Med 29:719-27. 2001
    OBJECTIVE: We attempted to determine whether group IIA secretory phospholipase A2 (sPLA2-IIA) blockade after the onset of lung injury exerted therapeutic efficacy in the treatment of oleic acid (OA)-induced acute lung injury by using S-..
  28. pmc Differential changes of adrenoceptor- and muscarinic receptor-linked prostacyclin synthesis by the aorta and urinary bladder of the diabetic rat
    J Y Jeremy
    Department of Chemical Pathology and Human Metabolism, Royal Free Hospital and School of Medicine, University of London
    Br J Pharmacol 108:1131-6. 1993
    ..Ca2+ ionophore A23187 (A23187) and thapsigargin (both elevate intracellular Ca2+, activating phospholipase A2 [PLA2]) and arachidonate (AA; substrate for PGI2 synthesis). 2...
  29. pmc Suppression of inflammatory responses to 12-O-tetradecanoyl-phorbol-13-acetate and carrageenin by YM-26734, a selective inhibitor of extracellular group II phospholipase A2
    A Miyake
    Molecular and Cellular Pharmacology, Dept, Yamanouchi Pharmaceutical Co Ltd, Tokyo, Japan
    Br J Pharmacol 110:447-53. 1993
    ..eny l) chroman] dose-dependently inhibited the activities of extracellular phospholipase A2 (PLA2): rabbit platelet-derived group II and porcine pancreas-derived group I PLA2, with IC50 values of 0.085 (0.056-0...
  30. ncbi Pharmacology of LY315920/S-5920, [[3-(aminooxoacetyl)-2-ethyl-1- (phenylmethyl)-1H-indol-4-yl]oxy] acetate, a potent and selective secretory phospholipase A2 inhibitor: A new class of anti-inflammatory drugs, SPI
    D W Snyder
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    J Pharmacol Exp Ther 288:1117-24. 1999
    LY315920 is a potent, selective inhibitor of recombinant human, group IIA, nonpancreatic secretory PLA2 (sPLA2). In a chromogenic isolated enzyme assay, LY315920 inhibited sPLA2 activity with an IC50 of 9 +/- 1 nM or 7...
  31. pmc Up-regulation of [3H]-des-Arg10-kallidin binding to the bradykinin B1 receptor by interleukin-1 beta in isolated smooth muscle cells: correlation with B1 agonist-induced PGI2 production
    J P Galizzi
    Cerep, Celle l evescault, France
    Br J Pharmacol 113:389-94. 1994
    ..This observation suggests that IL-1 but not LPS, in addition to increase in the number of receptors, signals the cell to permit the coupling of B1 receptors to the PLA2/cyclo-oxygenase pathway.
  32. ncbi Intracerebral injection of phospholipase A2 inhibits dopamine-mediated behavior in rats: possible implications for schizophrenia
    J Brunner
    Neurobiology Unit, Central Institute of Mental Health, Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 246:13-6. 1995
    Phospholipase A2 (PLA2) is a key enzyme in the phospholipid metabolism. In the CNS intracellular PLA2 plays an essential role in signal transduction by affecting both dopamine (DA) release and DA-receptor sensitivity...
  33. doi CC-PLA2-1 and CC-PLA2-2, two Cerastes cerastes venom-derived phospholipases A2, inhibit angiogenesis both in vitro and in vivo
    Raoudha Kessentini-Zouari
    Laboratoire des Venins et Toxines, Institut Pasteur de Tunis, Tunis, Tunisia
    Lab Invest 90:510-9. 2010
    ..CC-PLA2s also impaired in vitro human brain microvascular endothelial cell tubulogenesis on Matrigel and showed ..
  34. ncbi Affinity purification of phospholipase A2 on immobilized artificial membranes containing and lacking the glycerol backbone
    C Bernal
    Department of Medicinal Chemistry, School of Pharmacy, Perdue University, West Lafayette, IN 47907, USA
    J Chromatogr A 731:139-51. 1996
    ..PCC10/C3 lacks the glycerol backbone. Affinity purification of PLA2 on these IAM surfaces demonstrated that the surface structural differences were not important for phospholipase A2 (..
  35. ncbi Pancreatic phospholipase A2--mediated enhancement of the respiratory burst response of human neutrophils
    J Muller
    Institute of Medical Physics and Biophysics, Medical Faculty, University of Leipzig, Germany
    Z Naturforsch C 56:1150-6. 2001
    ..Pancreatic PLA2 was used because PMNs do not possess a receptor for that enzyme and, therefore, the receptor-mediated effects could ..
  36. ncbi Effect of neuroleptics on phospholipase A2 activity in the brain of rats
    H I Trzeciak
    Department of Pharmacology, Silesian Academy of Medicine, Katowice-Ligota, Poland
    Eur Arch Psychiatry Clin Neurosci 245:179-82. 1995
    The effect of neuroleptics on phospholipase A2 (PLA2) activity in rat brain plasma membranes was studied...
  37. ncbi Effect of a new inhibitor of type II phospholipase A2 on experimental acute pancreatitis in rats
    T Yoshikawa
    Department of Internal Medicine II, Nagoya University School of Medicine, Japan
    Pancreas 19:193-8. 1999
    The catalytic activity of type II phospholipase A2 (PLA2) in blood has been reported to increase in acute pancreatitis and to reflect the severity of pancreatitis...
  38. ncbi A new inhibitor of synovial phospholipase A2 from fermentations of Penicillium sp. 62-92
    L Witter
    Lehrbereich Biotechnologie, , Germany
    Z Naturforsch C 53:60-4. 1998
    ..No antimicrobial activity was detected for oxindole, and only weak antibacterial activity for penidiamide. The structure of penidiamide was elucidated by spectroscopic methods...
  39. ncbi Semisynthetic preparation of 1-O-hexadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine (platelet activating factor)
    M E Lekka
    Department of Chemistry, University of Ioannina, Greece
    Z Naturforsch C 43:665-70. 1988
    ..the chromatographic behaviour on TLC and HPLC, the physicochemical properties and the behaviour under treatment with PLA2 and Lipase from Rhizopus arrhizus. The above procedure is proposed as a facile, inexpensive and convenient method.
  40. ncbi Activation of BK channels in GH3 cells by a c-PLA2-dependent G-protein signaling pathway
    D D Denson
    Dept of Anesthesiology, Emory University School of Medicine, 3B South Emory University Hospital, 1364 Clifton Rd, Atlanta, GA 30322, USA
    J Neurophysiol 93:3146-56. 2005
    BK-channels in GH3 cells are activated by arachidonic acid produced by c-PLA2. beta-adrenergic agonists also activate BK channels and were presumed to do so via production of cAMP...
  41. ncbi Inhibition of inflammatory responses by epitaondiol and other marine natural products
    B Gil
    Department of Pharmacology, University of Valencia, Spain
    Life Sci 57:PL25-30. 1995
    ..This compound and epitaondiol decreased the release of eicosanoids with a higher potency on the cyclo-oxygenase pathway. Only epitaondiol inhibited human recombinant synovial phospholipase A2 activity in a concentration-dependent manner...
  42. doi Purification, characterization and bactericidal activities of basic phospholipase A2 from the venom of Agkistrodon halys (Chinese pallas)
    R Perumal Samy
    Venom and Toxin Research Programme, Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597
    Biochimie 90:1372-88. 2008
    Agkistrodon snake venoms contain a variety of phospholipases (PLA2), some of which are myotoxic. In this study, we used reverse-phase HPLC to purify PLA2 from the venom of Agkistrodon halys...
  43. pmc Distinct phospholipase A2 enzymes regulate prostaglandin E2 and F2alpha production by bovine endometrial epithelial cells
    Patricia K Tithof
    The University of Tennessee College of Veterinary Medicine, TN, USA
    Reprod Biol Endocrinol 5:16. 2007
    The rate-limiting step in prostaglandin (PG) biosynthesis is catalyzed by phospholipase A2 (PLA2) enzymes which hydrolyze arachidonic acid from membrane phospholipids...
  44. ncbi Determination of enzymatic activity and properties of secretory phospholipase A2 by capillary electrophoresis
    S Choi
    Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul, South Korea
    J Chromatogr A 853:285-93. 1999
    ..CE) system coupled with a diode array UV detector was used for the assay of secretory phospholipase A2 (sPLA2) activity...
  45. ncbi Prostaglandin release from lumbar disc and facet joint tissue
    R E Willburger
    Department of Orthopaedic Surgery, Ruhr University, Bochum, Germany
    Spine (Phila Pa 1976) 19:2068-70. 1994
    ..SUMMARY OF BACKGROUND DATA. High levels of phospholipase A2 (PLA2) have been measured in the human disc. PLA2 releases fatty acids from lipid membranes...
  46. ncbi 5-hydroxy-3-vinyl-2(5H)-furanone--a new inhibitor of human synovial phospholipase A2 and platelet aggregation from fermentations of a Calyptella species (basidiomycetes)
    K Lorenzen
    , Kaiserslautern, Bundesrepublik Deutschland
    Z Naturforsch C 50:403-9. 1995
    ..5-hydroxy-3-vinyl-2(5H)-furanone inhibits the aggregation of human and bovine platelets stimulated by different inducers and exhibits weak antimicrobial activities...
  47. ncbi Progesterone primes zona pellucida-induced activation of phospholipase A2 during acrosomal exocytosis in guinea pig spermatozoa
    Qi Xian Shi
    Zhejiang Academy of Medical Sciences, Hangzhou, Zhejiang, People s Republic of China
    J Cell Physiol 205:344-54. 2005
    We investigated, using guinea-pig spermatozoa as a model, whether phospholipase A2 (PLA2) is involved in progesterone or zona pellucida (ZP)-stimulated acrosomal exocytosis, if progesterone enhances ZP-induced activation of PLA2, and ..
  48. pmc Phospholipase A2 regulation of bovine endometrial (BEND) cell prostaglandin production
    James D Godkin
    Department of Animal Science, The University of Tennessee, Knoxville, TN, USA
    Reprod Biol Endocrinol 6:44. 2008
    ..Phospholipase A2 (PLA2) catalyzes the release of arachidonic acid from membrane phospholipids, the rate-limiting step in PG biosynthesis...
  49. ncbi Chymopapain-induced reduction of proinflammatory phospholipase A2 activity and amelioration of neuropathic behavioral changes in an in vivo model of acute sciatica
    P D Sawin
    Department of Pathology, The University of Iowa Hospitals and Clinics, Iowa City 52242, USA
    J Neurosurg 86:998-1006. 1997
    ..assessed the ability of chymopapain to modulate the activity of the proinflammatory enzyme phospholipase A2 (PLA2) and to ameliorate behavioral changes associated with inflammatory neuropathy in an in vivo model of sciatica...
  50. ncbi Oxalate toxicity in renal cells
    Julie A Jonassen
    Department of Physiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Urol Res 33:329-39. 2005
    ..Oxalate exposure activates phospholipase A2 (PLA2), which increases two lipid signaling molecules, arachidonic acid and lysophosphatidylcholine (Lyso-PC)...
  51. ncbi Role of various phospholipases A2 and inhibitors in the pathogenesis and prevention of pancreatic acinar cell necrosis: studies with isolated rat pancreatic acini
    J MOssner
    Department of Internal Medicine II, University of Leipzig, Germany
    Int J Pancreatol 27:29-38. 2000
    Phospholipase A2 (PLA2) may play a central role in the pathogenesis of pancreatic acinar cell necrosis...
  52. ncbi Role of cytochrome P450 in phospholipase A2- and arachidonic acid-mediated cytotoxicity
    Andres A Caro
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, Box 1603, One Gustave L Levy Place, New York, NY 10029, USA
    Free Radic Biol Med 40:364-75. 2006
    ..The PLA2 reaction is the primary pathway through which arachidonic acid (AA) is released from phospholipids. PLA2s have an important role in cellular death that occurs via necrosis or apoptosis...
  53. pmc Phospholipase A2 activity-dependent stimulation of Ca2+ entry by human parvovirus B19 capsid protein VP1
    Adrian Lupescu
    Physiologisches Institut, der Universität Tübingen, Gmelinstr 5, D 72076 Tubingen, Germany
    J Virol 80:11370-80. 2006
    ..A secreted phospholipase A2 (PLA2)-like activity has been located in the VP1 unique region of the B19 minor capsid protein...
  54. ncbi Binding of quinacrine to acidic phospholipids and pancreatic phospholipase A2. Effects on the catalytic activity of the enzyme
    P Mustonen
    Institute of Biomedicine, Department of Medical Chemistry, University of Helsinki, Finland
    Biochemistry 37:12051-7. 1998
    Binding of quinacrine to phospholipids and porcine pancreatic phospholipase A2 (PLA2) was investigated using fluorescence resonance energy transfer, Langmuir films, assay for the enzymatic activity, and molecular modeling...
  55. ncbi Phospholipase A2 is present in meconium and inhibits the activity of pulmonary surfactant: an in vitro study
    A J Schrama
    Department of Pediatrics, Leiden University Medical Center, The Netherlands
    Acta Paediatr 90:412-6. 2001
    ..g. fatty acids, inhibit surfactant activity. However, the role of the enzyme phospholipase A2 (PLA2), which hydrolyses surfactant in adult respiratory distress syndrome (ARDS), has not yet been studied...
  56. ncbi Ca2+-independent phospholipase A2 contributes to the insulinotropic action of cholecystokinin-8 in rat islets: dissociation from the mechanism of carbachol
    E Simonsson
    Department of Medicine, Lund University, Malmo, Sweden
    Diabetes 47:1436-43. 1998
    Insulin secretion induced by cholecystokinin-8 (CCK-8) was recently suggested to involve phospholipase A2 (PLA2) activation...
  57. ncbi Secretory low-molecular-weight phospholipases A2 and their specific receptor in bile ducts of patients with intrahepatic calculi: factors of chronic proliferative cholangitis
    J Shoda
    Department of Gastroenterology, Institute of Clinical Medicine, The University of Tsukuba, Ibaraki, Japan
    Hepatology 29:1026-36. 1999
    ..phospholipases A2 (sPLA2s) as inflammatory mediators or factors modulating cell functions via their specific sPLA2-receptor, and also on the production and secretion of altered mucin molecules from the inflamed bile ducts...
  58. ncbi Purification, characterization, and molecular cloning of group I phospholipases A2 from the gills of the red sea bream, Pagrus major
    N Iijima
    Faculty of Applied Biological Science, Hiroshima University, Higashihiroshima, Japan
    Lipids 35:1359-70. 2000
    Phospholipase A2 (PLA2) activity was investigated in various tissues of male and female red sea bream...
  59. ncbi Effect of crotapotin and heparin on the rat paw oedema induced by different secretory phospholipases A2
    E C Landucci
    Department of Pharmacology, Faculty of Medical Sciences, UNICAMP, Campinas, SP, Brazil
    Toxicon 38:199-208. 2000
    ..complexed with phospholipase A2) and heparin on rat paw edema induced by different secretory phospholipases A2 (sPLA2) have been investigated...
  60. ncbi Cyclic stretch-induced cPLA2 mediates ERK 1/2 signaling in rabbit proximal tubule cells
    Larry D Alexander
    Department of Medicine, Division of Nephrology and Hypertension, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, Ohio 44106 4982, USA
    Kidney Int 65:551-63. 2004
    Recent evidence from this laboratory have demonstrated a critical role of phospholipase A2 (PLA2) and arachidonic acid in angiotensin II type 2 (AT2) receptor-mediated kinase activation in renal epithelium independent of phosphoinositide- ..
  61. ncbi Dissociation between the phospholipases C and A2 activities in stimulated platelets and their involvement in the arachidonic acid liberation
    A Faili
    , , Institut Pasteur, Paris, France
    Br J Haematol 88:149-55. 1994
    In previous work we have demonstrated that platelets depleted from secretory phospholipase A2 (sPLA2) produced similar amounts of thromboxane (Tx)B2 as control platelets upon stimulation by thrombin...
  62. ncbi Graves' immunoglobulins activate phospholipase A2 by recognizing specific epitopes on thyrotropin receptor
    A Di Cerbo
    Division and Research Unit of Endocrinology, Istituto di Ricovero e Cura a Carattere Scientifico Casa Sollievo della Sofferenza General Hospital, San Giovanni Rotondo Foggia, Italy
    J Clin Endocrinol Metab 84:3283-92. 1999
    ..IgG from Graves' patients bind to the TSH receptor and activate both adenylyl cyclase (AC) and phospholipase A2 (PLA2) in FRTL5 thyroid cells...
  63. ncbi Mouse group X secretory phospholipase A2 induces a potent release of arachidonic acid from spleen cells and acts as a ligand for the phospholipase A2 receptor
    Y Morioka
    Shionogi Research Laboratories, Shionogi and Co, Ltd, Osaka, Japan
    Arch Biochem Biophys 381:31-42. 2000
    Group X secretory phospholipase A2 (sPLA2-X) has recently been shown to possess a powerful potency for releasing arachidonic acid from cell membrane phospholipids...
  64. ncbi Thiol-oxidizing agent diamide and acidic pH enhance lipid peroxidation of rat heart mitochondria and cardiolipin-cytochrome c complex
    H Iwase
    Department of Forensic Medicine, Graduate School of Medicine, The University of Tokyo, Japan
    IUBMB Life 51:39-43. 2001
    In this study, we investigated lipid peroxidation in rat heart mitochondria hydrolyzed by phospholipase A2 (PLA2) and lipid peroxidation in a mitochondrial-mimetic lipid peroxidation system, where phospholipids such as cardiolipin (CL) ..
  65. ncbi Cross-talk between cytosolic phospholipase A2 alpha (cPLA2 alpha) and secretory phospholipase A2 (sPLA2) in hydrogen peroxide-induced arachidonic acid release in murine mesangial cells: sPLA2 regulates cPLA2 alpha activity that is responsible for arachido
    Won K Han
    Medical Services, Massachusetts General Hospital, Department of Medicine and Anesthesia, Harvard Medical School, Massachusetts, USA
    J Biol Chem 278:24153-63. 2003
    ..We investigated the cross-talk between group IValpha cytosolic PLA2 (cPLA2alpha) and secretory PLA2s (sPLA2s) during H2O2-induced arachidonic acid (AA) release using two types of murine MC: (i)...
  66. ncbi CDP-choline significantly restores phosphatidylcholine levels by differentially affecting phospholipase A2 and CTP: phosphocholine cytidylyltransferase after stroke
    Rao Muralikrishna Adibhatla
    Department of Neurological Surgery, University of Wisconsin, Madison, WI 53792 3232, USA
    J Biol Chem 281:6718-25. 2006
    ..Transient middle cerebral artery occlusion (tMCAO) significantly increased PLA2 activity, secretory PLA2 (sPLA2)-IIA mRNA and protein levels, PtdCho-PLC activity, and PLD2 protein expression following reperfusion...
  67. ncbi PLA2 mediated arachidonate free radicals: PLA2 inhibition and neutralization of free radicals by anti-oxidants--a new role as anti-inflammatory molecule
    B L Nanda
    Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, India
    Curr Top Med Chem 7:765-77. 2007
    ..PLA2 enzymes have been classified into calcium dependent cPLA2 and sPLA2 and calcium independent iPLA2 forms...
  68. pmc Modulation of the pharmacological effects of enzymatically-active PLA2 by BTL-2, an isolectin isolated from the Bryothamnion triquetrum red alga
    Simone Cb Oliveira
    Biochemistry Department, Biology Institute, UNICAMP, Campinas, Sao Paulo, Brazil
    BMC Biochem 9:16. 2008
    An interaction between lectins from marine algae and PLA2 from rattlesnake was suggested some years ago...
  69. ncbi Porcine pancreatic phospholipase A2 stimulates secretin release from secretin-producing cells
    T M Chang
    Konar Center for Digestive and Liver Diseases, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 274:10758-64. 1999
    ..with secretin-releasing activity that had N-terminal sequence homology with canine pancreatic phospholipase A2 (PLA2)...
  70. doi Effect of umbelliferone (7-hydroxycoumarin, 7-HOC) on the enzymatic, edematogenic and necrotic activities of secretory phospholipase A2 (sPLA2) isolated from Crotalus durissus collilineatus venom
    D O Toyama
    Centro de Cidncias Biológicas e da Saúde, Univesidade Mackenzie, Sao Paulo, Brazil
    Toxicon 53:417-26. 2009
    ..their controlling effect on serine proteases is well acknowledged, their action on secretory phospholipase A2 (sPLA2) remains obscure...
  71. ncbi Coupling reaction and properties of poly(ethylene glycol)-linked phospholipases A2
    Ismael D Bianco
    CEPROCOR Agencia Córdoba Ciencia S E, Argentina
    Biosci Biotechnol Biochem 66:722-9. 2002
    ..Altogether, the results show a partial dissociation of catalytic and inflammatory activities of Group II and III secretory PLA2s after their modification with PEG.
  72. ncbi BE-I-PLA2, a novel acidic phospholipase A2 from Bothrops erythromelas venom: isolation, cloning and characterization as potent anti-platelet and inductor of prostaglandin I2 release by endothelial cells
    Jeanne Claine de Albuquerque Modesto
    Laboratorio de Bioquimica e Biofisica, Instituto Butantan, Sao Paulo SP, Brazil
    Biochem Pharmacol 72:377-84. 2006
    ..BE-I-PLA2 present a molecular weight of 13,649.57 Da as estimated by mass spectrometry...
  73. ncbi Complement-induced phospholipase A2 activation in experimental membranous nephropathy
    A V Cybulsky
    Department of Medicine, McGill University Health Center, Montreal, Quebec, Canada
    Kidney Int 57:1052-62. 2000
    ..By analogy, in cultured rat GEC, sublytic C5b-9 injures plasma membranes and releases arachidonic acid (AA) and eicosanoids, due to activation of phospholipase A2 (PLA2). This study addresses the mechanisms of PLA2 activation.
  74. ncbi PTH and phospholipase A2 in the aging process of intestinal cells
    Claudia Gentili
    Departamento de Biologia, Bioquimica and Farmacia, Universidad Nacional del Sur, 8000 Bahia Blanca, Argentina
    J Cell Biochem 93:312-26. 2004
    In this study we analyzed, for the first time, alterations in phospholipase A2 (PLA2) activity and response to parathyroid hormone (PTH) in rat enterocytes with aging...
  75. doi The role of lipoprotein-associated phospholipase A2 in atherosclerosis may depend on its lipoprotein carrier in plasma
    Constantinos C Tellis
    Laboratory of Biochemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece
    Biochim Biophys Acta 1791:327-38. 2009
    ..in plasma is complexed to lipoproteins; thus it is also referred to as lipoprotein-associated phospholipase A2 (Lp-PLA2)...
  76. pmc Role of arachidonic acid and its metabolites in the priming of NADPH oxidase in human polymorphonuclear leukocytes by peritoneal dialysis effluent
    I Daniels
    Medical Research Centre, City Hospital, Nottingham, United Kingdom
    Clin Diagn Lab Immunol 5:683-9. 1998
    ..We were unable to determine the relative roles of secretory PLA2 (sPLA2) and cytosolic PLA2 (cPLA2) since the selective sPLA2 inhibitor scalaradial (0 to 100 microM) inhibited oxidase ..
  77. ncbi Expression of members of the phospholipase A2 family of enzymes in human nasal mucosa
    J Lindbom
    Dept of Health and Environment, Faculty of Health Sciences, University of Linkoping, Sweden
    Eur Respir J 18:130-8. 2001
    Phospholipase A2 (PLA2) is a family of enzymes thought to play a key role in inflammation by releasing arachidonic acid for the synthesis of eicosanoids and lysophospholipid for the synthesis of platelet-activating factor...
  78. doi Crucial role of group IIA phospholipase A2 in pancreatitis-associated adrenal injury in acute necrotizing pancreatitis
    Sheng Xu
    Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430060, PR China
    Pathol Res Pract 206:73-82. 2010
    This study investigated the mechanistic role of group IIA phospholipase A2 (sPLA2-IIA) in the process of pancreatitis-associated adrenal injury in acute necrotizing pancreatitis...
  79. ncbi Synergistic effect of type II phospholipase A2 and platelet-activating factor on Mac-1 surface expression and exocytosis of gelatinase granules in human neutrophils: evidence for the 5-lipoxygenase-dependent mechanism
    J Takasaki
    Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Tsukuba, Ibaraki, Japan
    J Immunol 160:5066-72. 1998
    ..Type II phospholipase A2 (PLA2-II) also induces translocation of Mac-1 from secretory vesicles...
  80. ncbi Human neutrophil migration in vitro induced by secretory phospholipases A2: a role for cell surface glycosaminoglycans
    Alessandra Gambero
    Department of Pharmacology, Faculty of Medical Sciences, UNICAMP, PO Box 6111, 13081 970, Campinas, SP, Brazil
    Biochem Pharmacol 63:65-72. 2002
    ..m. mocambique and A. mellifera venom PLA2s (100 microg/mL each), but failed to affect the migration induced by porcine pancreas PLA2...
  81. ncbi The structural variations of epsilon-amino groups in phospholipase A2 enzymes from Naja naja atra and Bungarus multicinctus venoms
    L S Chang
    Department of Biochemistry, Kaohsiung Medical College, Taiwan, ROC
    J Protein Chem 16:133-7. 1997
    Comparative studies on Naja naja atra phospholipase A2 (NNA-PLA2), Bungarus multicinctus phospholipase A2 (BM-PLA2), and their Lys-modified derivatives were made to assess the differences in the fine structures around the conserved Lys ..
  82. ncbi Analysis of the secretory phospholipase A2 that mediates prostaglandin production in mast cells
    S T Reddy
    Department of Biological Chemistry, UCLA Center for the Health Sciences, Los Angeles, California 90095 1570, USA
    J Biol Chem 272:13591-6. 1997
    ..Early phase PGD2 synthesis in activated mast cells also requires the activity of a secretory phospholipase A2 (PLA2)...
  83. ncbi Role of phospholipase A2 activation and calcium in CYP2E1-dependent toxicity in HepG2 cells
    Andres A Caro
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 278:33866-77. 2003
    Previous studies suggested a role for calcium in CYP2E1-dependent toxicity. The possible role of phospholipase A2 (PLA2) activation in this toxicity was investigated...
  84. ncbi Secretory phospholipase A2 deposition on contact lenses and its effect on bacterial adhesion
    Emma B H Hume
    Vision Cooperative Research Centre, The University of New South Wales, Sydney, New South Wales, Australia
    Invest Ophthalmol Vis Sci 45:3161-4. 2004
    Secretory phospholipase A2 (sPLA2) is a potent antibacterial enzyme in tears and has been found to kill Staphylococcus aureus rapidly in vitro...
  85. ncbi Bee venom secretory phospholipase A2 and phosphatidylinositol-homologues cooperatively disrupt membrane integrity, abrogate signal transduction and inhibit proliferation of renal cancer cells
    Thomas Putz
    Department of Urology and kompetenzzentrum medizin tirol, Innsbruck Medical University, Innsbruck, Austria
    Cancer Immunol Immunother 56:627-40. 2007
    Bee venom secretory phospholipase A2 (bv-sPLA2) and phosphatidylinositol-(3,4)-bisphosphate (PtdIns(3,4)P2) act synergistically to induce cell death in tumour cells of various origins with concomitant stimulation of the immune system...
  86. doi Platelet glycoprotein IIIa (platelet antigen 1/platelet antigen 2) polymorphism and 1-year outcome in patients with stable coronary artery disease
    Faouzi Addad
    Department of Cardiology A, Fattouma Bourguiba University Hospital, Monastir, Tunisia
    Blood Coagul Fibrinolysis 21:674-8. 2010
    ..controversy regarding the clinical impact of glycoprotein IIIa platelet antigen 1 (PlA1)/platelet antigen 2 (PlA2) polymorphism as a risk factor for myocardial infarction...
  87. ncbi An update on inhibitors of human 14 kDa Type II s-PLA2 in development
    D M Springer
    Anti infective Chemistry, Bristol Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, P O Box 5100, Wallingford, CT 06492, USA
    Curr Pharm Des 7:181-98. 2001
    Recent progress in the development of inhibitors of human Type II s-PLA2 as potential anti-inflammatory agents is presented...
  88. ncbi Lack of phospholipase A2 mutations in neuroblastoma, melanoma and colon-cancer cell lines
    F G Haluska
    Department of Hematology Oncology, Massachusetts General Hospital, Boston 02114, USA
    Int J Cancer 72:337-9. 1997
    ..murine tumor-suppressor gene, Mom1, has been identified as the secretory phospholipase A2 (GDB nomenclature: PLA2G2A) gene...
  89. ncbi Enhancement of platinum-drug cytotoxicity in a human head and neck squamous cell carcinoma line and its platinum-resistant variant by liposomal amphotericin B and phospholipase A2-II
    P J Ferguson
    Department of Otolaryngology, University of Western Ontario and London Regional Cancer Centre, London, Canada
    Drug Metab Dispos 27:1399-405. 1999
    ..LipoAmph B in the presence of phospholipase A(2)-II (PLA2-II) was able to enhance cisplatin and carboplatin cytotoxicity as effectively as free Amph B in both cell lines...
  90. ncbi Lack of association between schizophrenia and the phospholipase-A(2) genes cPLA2 and sPLA2
    R M Frieboes
    Molecular Genetics Laboratory, Department of Psychiatry, Kiel University Hospital, Kiel, Germany
    Am J Med Genet 105:246-9. 2001
    ..1995: Med Hypotheses 45:605-613] strongly support cPLA2 (PLA2G4A) and sPLA2 (PLA2G1B) as candidate genes for schizophrenia...
  91. ncbi The role of phospholipases, cyclooxygenases, and lipoxygenases in cerebral ischemic/traumatic injuries
    John W Phillis
    Department of Physiology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Crit Rev Neurobiol 15:61-90. 2003
    ..In addition to phospholipases A1, B, C, and D, there are at least 19 groups of PLA2, including multiple cytosolic, calcium independent, and secretory isoforms...
  92. pmc Biosynthesis of anandamide and N-palmitoylethanolamine by sequential actions of phospholipase A2 and lysophospholipase D
    Yong Xin Sun
    Department of Biochemistry, Kagawa University School of Medicine, 1750 1 Ikenobe, Miki, Kagawa 761 0793, Japan
    Biochem J 380:749-56. 2004
    ..This stomach enzyme was identified as group IB sPLA2 (secretory PLA2), and its product was determined as N-acyl-1-acyl-lysoPE...
  93. ncbi Skeletal muscle degeneration induced by venom phospholipases A2: insights into the mechanisms of local and systemic myotoxicity
    Jose Maria Gutierrez
    Instituto Clodomiro Picado, Facultad de Microbiologia, Universidad de Costa Rica, San Jose, Costa Rica
    Toxicon 42:915-31. 2003
    ..Myotoxic PLA2s bind to acceptors in the plasma membrane, which might be lipids or proteins and which may differ in their affinity ..
  94. ncbi Increased phospholipase A2 and thromboxane but not prostacyclin production by placental trophoblast cells from normal and preeclamptic pregnancies cultured under hypoxia condition
    Robin S Bowen
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, PO Box 33932, Shreveport, LA 71130, USA
    Placenta 26:402-9. 2005
    ..whether hypoxia could promote vasoactivator thromboxane (TX) and prostacyclin (PGI2) as well as phospholipase A2 (PLA2) production by placental trophoblast cells (TCs) from normal and preeclamptic (PE) pregnancies...
  95. ncbi Phospholipase A2, reactive oxygen species, and lipid peroxidation in cerebral ischemia
    Rao Muralikrishna Adibhatla
    Department of Neurological Surgery, University of Wisconsin, Madison, WI 53792 3232, USA
    Free Radic Biol Med 40:376-87. 2006
    ..PLA2 enzymes have been classified as calcium-dependent cytosolic (cPLA2) and secretory (sPLA2) and calcium-independent (iPLA2) forms...
  96. doi Neuromuscular activity of BaTX, a presynaptic basic PLA2 isolated from Bothrops alternatus snake venom
    L A Ponce-Soto
    Departamento de Farmacologia, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, CP 6111, Campinas, SP, Brazil
    Comp Biochem Physiol C Toxicol Pharmacol 150:291-7. 2009
    ....
  97. doi Mechanistic study of the sPLA2-mediated hydrolysis of a thio-ester pro anticancer ether lipid
    Lars Linderoth
    Department of Chemistry, Technical University of Denmark, DK 2800 Kgs Lyngby, Denmark
    J Am Chem Soc 131:12193-200. 2009
    ..It appears that the enzyme-catalyzed hydrolysis of thio-esters follow a different pathway compared to the hydrolysis pathway of the free thio-ester...
  98. pmc Locus-specific dependency of endogenous silent loci on MOM1 and non-CG methylation in Arabidopsis thaliana
    Yoshiki Habu
    Division of Plant Sciences, National Institute of Agrobiological Sciences, Tsukuba, Japan
    Plant Signal Behav 5:724-6. 2010
    ..We recently revealed that MORPHEUS' MOLECULE1 (MOM1) of Arabidopsis thaliana silences endogenous loci related to transposons and homologous to the 24-nt siRNAs ..
  99. pmc Comparative efficacy of a secretory phospholipase A2 inhibitor with conventional anti-inflammatory agents in a rat model of antigen-induced arthritis
    Liam G Coulthard
    School of Biomedical Sciences, Research Road, University of Queensland, St, Lucia, Queensland, 4072, Australia
    Arthritis Res Ther 13:R42. 2011
    Previously, secretory phospholipase A2 (sPLA2) inhibition has been used as an adjunct to conventional rheumatoid arthritis therapy in human clinical trials without significant improvement of arthritic pathology...
  100. doi Genome characterization of a novel porcine bocavirus
    Wan Zhu Yang
    Department of Viral Diarrhea, National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Xuan Wu District, Beijing 100052, China
    Arch Virol 157:2125-32. 2012
    ..The phospholipase A2 (PLA2) site of VP1 and the secondary structure of VP2 of PBoV3C were also analyzed...
  101. ncbi Lipoprotein-associated phospholipase A2 and serum lipid levels in subjects with chronic periodontitis and hyperlipidemia
    Shuang Ying Zhou
    Department of Periodontlogy, Peking University School, Beijing, People s Republic of China
    Chin J Dent Res 15:25-9. 2012
    To evaluate the relationships between clinical periodontal parameters and levels of lipoprotein-associated phospholipase A2 (Lp-PLA2) and lipid profile markers in subjects with or without hyperlipidaemia.

Research Grants65

  1. ALTERED CARDIAC MYOCYTE SIGNALING IN DIABETIC MYOCARDIUM AND FUNCTIONAL SEQUELAE
    ANTHONY JUSTIN MUSLIN; Fiscal Year: 2010
    ..Several intracellular PLA2s are expressed in heart, including cPLA2 and iPLA2 ...
  2. The Impact of Omega three Fatty Acids on Vascular Function and cIMT in HIV
    Christine A Wanke; Fiscal Year: 2013
    ..on HDL-C levels, HDL subprofiles, composition of membrane phospholipids, chronic inflammation as measured by CRP, sPLA2 and by levels of arachidonic acid. 3...
  3. Studies of Eicosanoid Biosynthetic Proteins
    Wonhwa Cho; Fiscal Year: 2013
    ..An important theme derived from our previous studies on PLA2s, including secretory group V PLA2 (gVPLA2) and cytosolic group IVA PLA2 (cPLA21), is that the spatiotemporal ..
  4. Biology, Immunology &therapy of Acanthamoeba Keratitis
    Hassan Alizadeh; Fiscal Year: 2013
    ..cells and induces both apoptosis and arachidonic acid release through a novel pathway involving phospholipase A2 (PLA2) activation...
  5. Role of phospholipase A2 in spinal cord secondary injury
    Xiao Ming Xu; Fiscal Year: 2013
    ..A candidate molecule that could serve as a convergence mediator is the enzyme phospholipase A2 (PLA2)...
  6. Michael H Gelb; Fiscal Year: 2016
    ..Mammals also contin an sPI_A2 receptor, the M-type sPLA2 receptor, which was discovered by use of venom sPLA2s...
  7. CYTOSOLIC PHOSPHOLIPASE A2 TRANSFORMED CELLS
    Raphael Nemenoff; Fiscal Year: 2002
    ..Phospholipase A2 (PLA2), which hydrolyzes the sn-2 bond of membrane phospholipids, is the enzyme controlling arachidonic acid release...
  8. Gadiparthi N Rao; Fiscal Year: 2015
    ..Phospholipase A2s (PLA2s) play an important role in inflammation...
  9. Gadiparthi N Rao; Fiscal Year: 2016
    ..Phospholipase A2s (PLA2s) play an important role in inflammation...
  10. Michael A Collins; Fiscal Year: 2016
    ..edema and neurodamage);(c) involves oxidative stress (antioxidants neuroprotect);and (d) requires phospholipase A2 (PLA2) activation, which mobilizes (JO-6 arachidonic acid (AA), a free radical source (PLA2 inhibitors reduce neurodamage)..
  11. Smooth muscle cell lipid metabolism and serum amyloid A
    Barbara M Schreiber; Fiscal Year: 2010
    ..Our gene microarray analysis showed that SAA induces expression of secretory phospholipase A2 (sPLA2) and calcium-dependent cytosolic phospholipase A2 (cPLA2)...
  12. PHOSPHOLIPID TURNOVER IN EXOCRINE PANCREAS
    Ronald Rubin; Fiscal Year: 1991
    ..that the interactions of a phospholipase C (PLC)-mediated pathway, and a Ca2+-dependent phospholipase A2 (PLA2) pathway play a pivotal role in stimulus-secretion coupling in exocrine glands...
  13. Comprehensive biomarker study to capitalize on existing GWAS in 10K South Asians
    Danish Saleheen; Fiscal Year: 2010
    ..apoC-III, apoE, lipoprotein(a), lipoprotein subclasses, oxidized phospholipids, authoantibodies to oxLDL, LpPLA2, sPLA2, myeloperoxidase);(2) insulin resistance and adiposity (insulin, C-peptide, adiponectin, leptin, resistin, liver ..
  14. William M Nauseef; Fiscal Year: 2016
    ..In addition to PMN, a specific Group IIA phospholipase A2 (GpIIA-PLA2), which is present in plasma of infected animals, tears, and inflammatory fluid, exhibits ..
  15. SPORE in Pancreatic Cancer
    James Abbruzzese; Fiscal Year: 2009
    ..This project will specifically examine the hypothesis that EGF-EGF receptor interactions control PLA2 and COX2 expression in pancreatic cancer cells and that COX-2 regulates an important cell survival pathway...
  16. Aron B Fisher; Fiscal Year: 2016
    ..developed a model based on lipid binding studies for the coordination of the peroxidase (Prx) and phospholipase (PLA2) activities of the protein. We are now seeking 5 years of support to extend these studies...
  17. HDL Structure and Metabolism During Inflammation
    Frederick C de Beer; Fiscal Year: 2011
    ..concomitantly induce the inflammatory phospholipases particularly group MA secretory phospholipase A2 (group IIA sPLA2) that hydrolyze HDL surface phospholipids with significant metabolic sequelae...
  18. Barbara Balestrieri; Fiscal Year: 2016
    ..Group V secretory phospholipase A2 (sPLA2) is an enzyme that generates lipid mediators from membrane phospholipids and has critical functions in innate ..
  19. Edward A Dennis; Fiscal Year: 2016
    ..with large lipid interfaces and specific potent inhibitors as we have done earlier under this grant with the GIA sPLA2 and GIVA cPLA2...
  20. PHYSIOLOGIC PHOSPHOLIPASE A2 ACTIVATION IN NEUTROPHILS
    SUE BAULDRY; Fiscal Year: 2000
    ..that PMN contain two calcium-dependent PLA2/s, a "cytosolic" enzyme, cPLA2, and a "secretory" enzyme, sPLA2, has led to intense interest in determining whether one or both are responsible for their formation...
  21. Elucidating the Role of Phospholipase in the Epidemic Typhus Rickettsia
    JONATHON PETER AUDIA; Fiscal Year: 2010
    ..by applicant): The long-term goal of this R01 application is to elucidate the role(s) of secreted phospholipase A2 (PLA2) in Rickettsia prowazekii pathobiology. R...
  22. Robert D Arnold; Fiscal Year: 2016
    ..Secretory phospholipases A2 (sPLA2) are excreted and over expressed in a variety of tumors, e.g., up to 22-fold in prostate...
  23. sPLA2 Selective Degradation of Nanoparticles
    BRIAN S contact CUMMINGS; Fiscal Year: 2010
    ..data demonstrates that human prostate cancers have significantly higher levels of secretory phospholipase A2 (sPLA2) activity and expression compared to control tissue...
  24. Eugene A Podrez; Fiscal Year: 2016
    ..Our preliminary studies demonstrated that a class of products formed as a result of degradation of oxPCCD36 by PLA2 (carboxyalkylpyrolle protein adducts) is a new and powerful platelet agonist, however, the receptors mediating its ..
  25. GLYCEROLIPIDS AND PROSTAGLANDIN BIOSYNTHESIS
    ATA ABDEL LATIF; Fiscal Year: 2001
    ..The central hypothesis to be tested is that phospholipase A2 (PLA2) activation is a major source for AA release in the ICB...
  26. Astrocytes role in lipid mediated synaptic activity
    Nathan A Smith; Fiscal Year: 2012
    ..In line with this, astrocytes possess Ca2+ -independent PLA2 that can lead to the production of AA in the absence of calcium...
  27. Group X sPLA2: Regulator of lipolysis and glucose homeostasis
    Nancy R Webb; Fiscal Year: 2013
    ..Based on our preliminary findings, we hypothesize that GX sPLA2 expressed by adipose tissue macrophages modulates the equilibrium between adipocyte lipid storage and lipid ..
  28. Action of Phospholipase A2 on Apoptotic Cells
    John Bell; Fiscal Year: 2005
    Secretory phospholipase A2 (sPLA2) binds to lipid bilayers and catalyzes hydrolysis of phospholipids. Normally, cells resist the enzyme's action, but they become susceptible during apoptosis or trauma...
  29. NFkB in the Astrocyte Swelling/Brain Edema with Acute Liver Failure
    MICHAEL DAVID NORENBERG; Fiscal Year: 2012
    ..their interaction with inflammatory enzymes, including inducible nitric oxide synthase (iNOS), phospholipase A2 (PLA2), and cyclooxygenase-2 (COX-2) that are regulated by NF-kB, will be investigated...
  30. Lu Qi; Fiscal Year: 2016
    ..Macrophages, a key component of adipose tissue, secrete lipoprotein- associated phospholipase A2 (Lp-PLA2), which hydrolyzes oxidized LDL releasing inflammatory products...
  31. CORONARY DISEASE MORBIDITY AND MORTALITY IN A POPULATION
    Veronique L Roger; Fiscal Year: 2012
    ..Protein (CRP) was associated with heart failure (HF) and death while lipoprotein- associated phospholipase A2 (Lp-PLA2), was associated with death but not HF or ischemia post MI...
  32. Kenneth A Kudsk; Fiscal Year: 2015
    ..The Paneth cells are the source of an important innate immune molecule, secretory phospholipase A2 (sPLA2)...
  33. Haichao Wang; Fiscal Year: 2016
    ..g., HMGB1, sPLA2, or others) accumulation, leukocyte infiltration and bacterial clearance, or hepatic injury from excessive ..
  34. Cell Models for Alzheimer's disease (AD): Lipids and Related Signaling Pathways
    Grace Y Sun; Fiscal Year: 2012
    ..projects will test the hypotheses that: (1) progression of AD involves expression and activation of the cPLA?/sPLA2/NADPH oxidase pathways to induce inflammatory responses in glial cells and impairment of neuronal functions;(2) ..
  35. Kathryn M Rexrode; Fiscal Year: 2016
    ..Additionally, markers of endothelial inflammation including Lp-PLA2, and IL-18 will be examined. Finally, telomere length, a marker of biologic aging, will be examined...
  36. Aging Stratum Corneum pH and Barrier Function
    Theodora M Mauro; Fiscal Year: 2012
    ..the combined activity of two endogenous mechanisms, the Na+/H+ antiporter (NHE1) and the secretory phospholipase (sPLA2) enzymes, although the relative contribution of each agent in supplying SC acidity to specific regions of the SC ..
  37. Functional and Structural Studies of CD74 Activation
    Elias Lolis; Fiscal Year: 2010
    ..examine the requirement for CD74 in various signaling pathways responsible for MIF biology (MAP kinase cytoplasmic PLA2 activation, expression and activation of COX-2, expression of Toll-like receptor 4, counter-regulation of ..
  38. Lie Gao; Fiscal Year: 2014
    ..This includes the NO/cGMP and PLA2/AA/12-LO/PP2A pathways...
  39. S Jamal Mustafa; Fiscal Year: 2015
    ..endothelial cells (release of NO from A2A andA2B (and A2A/A2B) and the coupling of A1 and A3 (and A1/A3) to PLA2;and the signaling in CASMC in A2A, A2B and A2A/A2B (PKA-p38-MAPK-HSP20) and in A1, A3 and A1/ A3 (PLC2III, PKC1, ..
  40. Group V Phospholipase A2 and Pulmonary Inflammation
    Howard R Katz; Fiscal Year: 2012
    ..application is to understand the biological function(s) of an enzyme termed secretory group V phospholipase A2 (sPLA2), particularly as it pertains to control of infections and pulmonary inflammation...
  41. Teal S Hallstrand; Fiscal Year: 2016
    ..This application for sustained support focuses on secreted phospholipase A2 group X (sPLA2-X) in the pathophysiology of asthma...
  42. Aron B Fisher; Fiscal Year: 2015
    ..the mechanism for Prdx6-mediated activation of NOX2;we propose that generation of lysoPC by the phospholipase A2 (PLA2) activity of Prdx6 is responsible...
  43. BIOCHEMICAL STUDIES OF 14 KDA PHOSPHOLIPASES A2
    Michael Gelb; Fiscal Year: 2006
    DESCRIPTION: (provided by applicant) Phospholipases A2 (PLA2s) catalyze the hydrolysis of the sn-2 ester of membrane phospholipids to produce a free fatty acid and a lysophospholipid...
  44. Cellular and molecular biology of lung surfactant
    Aron B Fisher; Fiscal Year: 2013
    ..This PLA2 is responsible for DPPC degradation following internalization by type II cells and is also required for PC ..
  45. William J Brown; Fiscal Year: 2016
    ..characterize PLA and LPAT enzymes involved in intracellular membrane trafficking;2) determine the contribution of PLA2 and LPAT enzymes to the production of Golgi coated vesicles and membrane tubules;and 3) determine the molecular ..
  46. PAIN EVOKED RELEASE OF AMINO ACIDS AND PROSTANOIDS
    Tony L Yaksh; Fiscal Year: 2012
    ..that one component of this facilitation arises from lipid mediator release by a constitutively active P38MAPK-PLA2-COX2 cascade...
  47. Lp-PLA2 and Coronary Atherosclerosis in Humans
    Amir Lerman; Fiscal Year: 2013
    ..Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a novel biomarker for vascular wall inflammation that circulates in the blood bound to both low density (LDL) ..
  48. Pla2g2a, Runx1 and Colorectal Cancer Risk
    Robert Cormier; Fiscal Year: 2009
    ..Our previous studies have focused on the secretory phospholipase A2 gene Pla2g2a, which has been identified as a susceptibility gene for intestinal cancer...
  49. Function of secreted PLA2 group X in eosinophil biology
    Teal S Hallstrand; Fiscal Year: 2013
    ..We have discovered that secreted PLA2 group X (sPLA2-X) is involved in eosinophil CysLT synthesis, contradicting the long-held view that cytosolic PLA2[unreadable] (..
  50. New Approach to Phospholipidosis Prediction
    Piotr W Rzepecki; Fiscal Year: 2011
    ..These methods have been judged unsatisfactory by the FDA. Human lysosomal phospholipase A2 (LPLA2, group XV PLA2) is a phospholipid processing enzyme central to DIPL...
  51. Roles for Phospholipase A2 Signaling in Prostate Development
    EDWARD MATTHEW SCHAEFFER; Fiscal Year: 2012
    ..Relevance: Pla2 modulates inflammatory responses...
  52. Novel Direct Approaches Toward Bioactive Heterocycles
    Vladimir Gevorgyan; Fiscal Year: 2013
    ..various diversely substituted indolizines not easily available by existing techniques, potential selective group V sPLA2 inhibitors;lamellarin D and its analogs;novel lamellarin-campthothecin hybrid pentacyclic scaffolds, potential ..
  53. Avtar K Singh; Fiscal Year: 2015
    ..proposal is based on our original findings that psychosine-induced apoptotic loss of OLs is mediated via the sPLA2 signaling pathway and that inhibitors of sPLA2 protect against loss of PPAR/peroxisomal functions and loss of OLs...
  54. GTP IN PHOSPHOLIPASE ACTIVATION AND INSULIN RELEASE
    STEWART METZ; Fiscal Year: 2000
    Our recent studies indicated that a phospholipase A2 (PLA2) and a phospholipase D (PLD) are present in pancreatic islets; furthermore, the phospholipid hydrolysis products which they generate (arachidonic acid, lysophospholipids, and ..
  55. PROPERTIES OF CHEMICALLY MODIFIED PHOSPHOLIPASE A-2
    Philip Rosenberg; Fiscal Year: 1993
    Our long term objective is to determine why proteins with phospholipase A2 (PLA2) activity differ so markedly in their toxicological and pharmacological properties even though they have similar enzymatic activities...
  56. EVALUATION OF LIPOXYGENASE-DERIVED PRODUCTS AS MEDIATORS
    Charles Serhan; Fiscal Year: 1990
    ..2) Extracellular phospholipase A2 (PLA2) activity will be determined n and isolated from pleural and synovial fluids...
  57. CDP-choline: Mechanisms in Cerebral Ischemia
    RAO ADIBHATLA; Fiscal Year: 2006
    ..membrane and mitochondrial phospholipase A2 (PLA2) that is raM-Ca 2+ dependent (characteristic of secretory PLA2; sPLA2), supporting the hypothesis and Aim 1...
  58. MECHANISMS OF PHOSPHOLIPASE A2 REGULATION
    John Bell; Fiscal Year: 1990
    ..of this research project is to understand the molecular mechanisms of cellular regulation of phospholipase A2 (PLA2). PLA2 is the first enzyme in the biosynthesis of prostaglandins, leukotrienes and platelet activating factor...
  59. PLASMALOGEN-SELECTIVE PLA2 ACTIVATION IN ISCHEMIA
    Jane McHowat; Fiscal Year: 1999
    ..LPC) production which appears to be mediated by activation of a novel calcium-independent phospholipase A2 (PLA2) with a distinct preference for ether-linked phospholipid substrates, including plasmalogens...
  60. REGULATION OF PROSTAGLANDIN BIOSYNTHESIS IN PARTURITION
    EDWARD DENNIS; Fiscal Year: 1999
    ..is the release of arachidonic acid from the sn-2 position of membrane phospholipids by phospholipase (PLA2)...
  61. In vivo biosensor screen for mutants in lipid metabolism
    Steven Farber; Fiscal Year: 2005
    ..We produced fluorescent lipids that are substrates for phospholipase A2 (PLA2), an important signaling and digestive enzyme present in the cytoplasm and brush border of the intestinal ..
  62. Regulatory Mechanisms of Secretory Phospholipases A2
    SUREN TATULIAN; Fiscal Year: 2004
    ..b>PLA2s hydrolyze phospholipids to free fatty acids and lysolipids and thus initiate the biosynthesis of eicosanoids and ..
  63. The Function of Phospholipase A2 in Islet Beta-cells
    Zhongmin Ma; Fiscal Year: 2007
    ..polypeptide (GIP) and cholecystokinin-8 (CCK-8) also stimulate release of AA by activating islet phospholipase A2 (PLA2)...
  64. PLA2 activation by mast cell tryptase in IC
    Jane McHowat; Fiscal Year: 2007
    ..receptor-2 (PAR-2) on urothelial and endothelial cells in the bladder and resulting in increased phospholipase A2 (PLA2) activity and accelerated production of inflammatory phospholipid metabolites such as eicosanoids and platelet ..
  65. PLATELET P1A2--STUDIES ON A PRO THROMBOTIC POLYMORPHISM
    Paul Bray; Fiscal Year: 2001
    ..are highly polymorphic, and our preliminary studies demonstrate a statistically significant association between the PlA2 polymorphism on beta3 and premature ischemic coronary events, particularly in young individuals...