PKC zeta

Summary

Gene Symbol: PKC zeta
Description: protein kinase C zeta
Alias: PKC-ZETA, PKC2, protein kinase C zeta type, nPKC-zeta
Species: human

Top Publications

  1. pmc Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism
    Darren J Powell
    Division of Molecular Physiology, MRC Protein Phosphorylation Unit, MSI WTB complex, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    Mol Cell Biol 23:7794-808. 2003
  2. pmc The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix
    S Swingler
    Infectious Disease Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Virol 71:4372-7. 1997
  3. ncbi Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2
    Kristina Lorenz
    Institut fur Pharmakologie und Toxikologie, Versbacher Strasse 9, D 97078 Wurzburg, Germany
    Nature 426:574-9. 2003
  4. ncbi Thrombin stimulation of vascular adhesion molecule-1 in endothelial cells is mediated by protein kinase C (PKC)-delta-NF-kappa B and PKC-zeta-GATA signaling pathways
    Takashi Minami
    Department of Molecular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 278:6976-84. 2003
  5. ncbi Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein
    Kevin C Corbit
    Department of Neurobiology, Pharmacology and Physiology, and Ben May Institute for Cancer Research, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 278:13061-8. 2003
  6. pmc Protein kinase C-mediated modulation of FIH-1 expression by the homeodomain protein CDP/Cut/Cux
    Jinping Li
    Department of Biochemistry and Molecular Biology, Gugg 1401A, Mayo Clinic College of Medicine, 200 First Street SW, Rochester MN 55905, USA
    Mol Cell Biol 27:7345-53. 2007
  7. ncbi Abeta(1-42) stimulated T cells express P-PKC-delta and P-PKC-zeta in Alzheimer disease
    Sebastiano Miscia
    Cell Signalling Unit, Department of Biomorphology, University G d Annunzio of Chieti Pescara, Chieti, Italy
    Neurobiol Aging 30:394-406. 2009
  8. pmc Protein kinase C-epsilon regulates sphingosine 1-phosphate-mediated migration of human lung endothelial cells through activation of phospholipase D2, protein kinase C-zeta, and Rac1
    Irina Gorshkova
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 283:11794-806. 2008
  9. pmc Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes
    K Conant
    Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA
    J Virol 70:1384-9. 1996
  10. pmc The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex
    Yungfeng Feng
    Department of Medicine, Washington University, St Louis, Missouri 63110, USA
    Mol Cell Biol 25:4010-22. 2005

Research Grants

  1. PKC zeta-Specific Inhibitors for Treatment of Methamphetamine Addiction
    Jiyong Hong; Fiscal Year: 2010
  2. Protein Kinase C (PKC) Zeta and the Pancreatic Beta Cell
    Adolfo Garcia-Ocana; Fiscal Year: 2012
  3. PKC zeta as a Target for Ceramide
    Mark Kester; Fiscal Year: 2010
  4. NAOMI MIRIAM HAMBURG; Fiscal Year: 2014
  5. ADIPOCYTE PROTEIN SECRETION AND INSULIN ACTION
    Harvey Lodish; Fiscal Year: 2007
  6. Role of atypical PKCs in Pancreatic Tumor Growth and Metastasis
    Nicole R Murray; Fiscal Year: 2010
  7. Transporter Mechanism of Amphetamine Sensitization
    Rong Chen; Fiscal Year: 2011
  8. VALIDATING AND TARGETING LYSOPHOSPHATIDIC ACID ACYLTRANSFERASE-BETA IN CANCER
    Gregory Springett; Fiscal Year: 2013
  9. MICHAEL ARCHIBALD FARRAR; Fiscal Year: 2015
  10. Validation of MALDI-MS-based inhibitor screening technologies for cancer targets
    KENNETH DONALD GREIS; Fiscal Year: 2012

Detail Information

Publications255 found, 100 shown here

  1. pmc Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism
    Darren J Powell
    Division of Molecular Physiology, MRC Protein Phosphorylation Unit, MSI WTB complex, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    Mol Cell Biol 23:7794-808. 2003
    ....
  2. pmc The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix
    S Swingler
    Infectious Disease Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Virol 71:4372-7. 1997
    ..Recombinant p21-activated kinase hPAK65, a recently proposed relative of the Nef-associated kinase, achieved a comparable result. Taken together, these data suggest that MA is a target of the Nef-associated serine kinase...
  3. ncbi Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2
    Kristina Lorenz
    Institut fur Pharmakologie und Toxikologie, Versbacher Strasse 9, D 97078 Wurzburg, Germany
    Nature 426:574-9. 2003
    ..A physiological role for this mechanism is shown in cardiomyocytes in which the downregulation of RKIP restrains beta-adrenergic signalling and contractile activity...
  4. ncbi Thrombin stimulation of vascular adhesion molecule-1 in endothelial cells is mediated by protein kinase C (PKC)-delta-NF-kappa B and PKC-zeta-GATA signaling pathways
    Takashi Minami
    Department of Molecular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 278:6976-84. 2003
    ..Taken together, these data suggest that the endothelial cell-specific effect of thrombin on VCAM-1 expression involves the coordinate activity of PKC-delta-NF-kappaB and PKC-zeta-GATA signaling pathways...
  5. ncbi Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein
    Kevin C Corbit
    Department of Neurobiology, Pharmacology and Physiology, and Ben May Institute for Cancer Research, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 278:13061-8. 2003
    ..Taken together, these results constitute the first model showing how phosphorylation by PKC relieves a key inhibitor of the Raf/MAP kinase signaling cascade and may represent a general mechanism for the regulation of MAP kinase pathways...
  6. pmc Protein kinase C-mediated modulation of FIH-1 expression by the homeodomain protein CDP/Cut/Cux
    Jinping Li
    Department of Biochemistry and Molecular Biology, Gugg 1401A, Mayo Clinic College of Medicine, 200 First Street SW, Rochester MN 55905, USA
    Mol Cell Biol 27:7345-53. 2007
    ..immunoprecipitation assays, we show that CDP binds to the FIH-1 promoter in vivo and that this binding is PKC zeta dependent...
  7. ncbi Abeta(1-42) stimulated T cells express P-PKC-delta and P-PKC-zeta in Alzheimer disease
    Sebastiano Miscia
    Cell Signalling Unit, Department of Biomorphology, University G d Annunzio of Chieti Pescara, Chieti, Italy
    Neurobiol Aging 30:394-406. 2009
    ..We believe that these findings may be of help in possible attempts to develop further diagnostic strategies useful for the characterization of AD...
  8. pmc Protein kinase C-epsilon regulates sphingosine 1-phosphate-mediated migration of human lung endothelial cells through activation of phospholipase D2, protein kinase C-zeta, and Rac1
    Irina Gorshkova
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 283:11794-806. 2008
    ..Activation of this pathway is necessary to stimulate the migration of lung endothelial cells, a key component of the angiogenic process...
  9. pmc Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes
    K Conant
    Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA
    J Virol 70:1384-9. 1996
    ..These effects include Tat's ability to upregulate the synthesis of specific cytokines and to act as a growth factor...
  10. pmc The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex
    Yungfeng Feng
    Department of Medicine, Washington University, St Louis, Missouri 63110, USA
    Mol Cell Biol 25:4010-22. 2005
    ..We propose that Ajuba is a new cytosolic component of the IL-1 signaling pathway modulating IL-1-induced NF-kappaB activation by influencing the assembly and activity of the aPKC/p62/TRAF6 multiprotein signaling complex...
  11. pmc Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha
    K S Walker
    MRC Protein Phosphorylation Unit, Department of Biochemistry, University of Dundee, Dundee DD1 4HN, Scotland, U K
    Biochem J 331:299-308. 1998
    ..Insulin did not induce PKBgamma activity in adipocytes, hepatocytes or skeletal muscle, but PKBgamma was the major isoform activated by insulin in rat L6 myotubes (a skeletal-muscle cell line)...
  12. ncbi The roles of phosphatidylinositol 3-kinase and protein kinase Czeta for thrombopoietin-induced mitogen-activated protein kinase activation in primary murine megakaryocytes
    P Rojnuckarin
    Division of Hematology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Biol Chem 276:41014-22. 2001
    ..These data demonstrate a novel role of PI3K and PKCzeta in steady-state megakaryopoiesis...
  13. ncbi Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1
    Toshitsugu Fujita
    Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567 0047, Japan
    Biochem Biophys Res Commun 313:738-44. 2004
    ..These results suggest that FEZ2 plays an important role in the morphological changes of various cells by associating with PKCzeta in a tissue-non-specific manner...
  14. pmc Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway
    J Park
    Friedrich Miescher Institut, Maulbeerstrasse 66, CH 4056 Basel, Switzerland
    EMBO J 18:3024-33. 1999
    ..Both hyperphosphorylation and nuclear translocation could be inhibited by wortmannin, but not by rapamycin...
  15. pmc 14-3-3 isotypes facilitate coupling of protein kinase C-zeta to Raf-1: negative regulation by 14-3-3 phosphorylation
    P C van der Hoeven
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Biochem J 345:297-306. 2000
    ..We conclude that 14-3-3 facilitates coupling of PKC-zeta to Raf-1 in an isotype-specific and phosphorylation-dependent manner. We suggest that 14-3-3 is a transient mediator of Raf-1 phosphorylation and activation by PKC-zeta...
  16. ncbi Activation of protein kinase C-zeta by insulin and phosphatidylinositol-3,4,5-(PO4)3 is defective in muscle in type 2 diabetes and impaired glucose tolerance: amelioration by rosiglitazone and exercise
    Mary Beeson
    Department of Internal Medicine, Division of Endocrinology and Metabolism, University of South Florida College of Medicine, Tampa, Florida, USA
    Diabetes 52:1926-34. 2003
    ..Defective aPKC activation contributes to skeletal muscle insulin resistance in IGT and type 2 diabetes, rosiglitazone improves insulin-stimulated aPKC activation, and exercise directly activates aPKCs in diabetic muscle...
  17. ncbi Rab2 interacts directly with atypical protein kinase C (aPKC) iota/lambda and inhibits aPKCiota/lambda-dependent glyceraldehyde-3-phosphate dehydrogenase phosphorylation
    Ellen J Tisdale
    Department of Pharmacology, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA
    J Biol Chem 278:52524-30. 2003
    ..These results suggest that a downstream effector recruited to the VTC stimulates PKCiota/lambda-mediated GAPDH phosphorylation by alleviating the inhibition imposed by Rab2-PKCiota/lambda interaction...
  18. pmc Phosphatidylinositol 3-kinase/protein kinase Czeta-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated derepression [corrected] of transcription of the luteinizing hormone receptor gene
    Ying Zhang
    Section on Molecular Endocrinology, Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development NIH, 49 Convent Drive MSC 4510, Bethesda, MD 20892 4510, USA
    Mol Cell Biol 26:6748-61. 2006
    ..These studies have revealed a novel mechanism of TSA action through derecruitment of a repressor from the LHR gene promoter in a PI3K/PKCzeta-induced Sp1 phosphorylation-dependent manner...
  19. pmc Atypical protein kinase C regulates dual pathways for degradation of the oncogenic coactivator SRC-3/AIB1
    Ping Yi
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cell 29:465-76. 2008
    ..Our results demonstrate a potent signaling mechanism for regulating SRC-3 levels in cells by coordinate enzymatic inhibition of both ubiquitin-dependent and ubiquitin-independent proteolytic pathways...
  20. doi Spisulosine (ES-285) induces prostate tumor PC-3 and LNCaP cell death by de novo synthesis of ceramide and PKCzeta activation
    Ana M Sanchez
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Alcala, 28871 Alcala de Henares, Madrid, Spain
    Eur J Pharmacol 584:237-45. 2008
    ..These results indicate that the marine compound Spisulosine inhibits the growth of the prostate PC-3 and LNCaP cells through intracellular ceramide accumulation and PKCzeta activation...
  21. pmc HIV-1 Tat and AIDS-associated cancer: targeting the cellular anti-cancer barrier?
    Giuseppe Nunnari
    University of Catania, Department of Medicine and Medical Specialties, Division of Infectious Diseases, Via Palermo 636, Catania, Italy
    J Exp Clin Cancer Res 27:3. 2008
    ..We propose that the Tat-induced DNA repair deficiencies may play a significant role in the development of AIDS-associated cancer...
  22. ncbi A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx
    C L Ruegg
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    Cell Immunol 137:1-13. 1991
    ....
  23. ncbi Inhibition of protein kinase C and anti-CD3-induced Ca2+ influx in Jurkat T cells by a synthetic peptide with sequence identity to HIV-1 gp41
    C L Ruegg
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    J Immunol 144:3928-35. 1990
    ....
  24. pmc Trans-activation of HIV-1 LTR-directed gene expression by tat requires protein kinase C
    A Jakobovits
    Department of Molecular Biology, Genentech, Inc, South San Francisco, CA 94080
    EMBO J 9:1165-70. 1990
    ..Our results indicate that PKC regulates the process of HIV-1 transactivation, suggesting a key role for the mitogenic induction of trans-activation in the transition of HIV from latency to productive growth...
  25. ncbi Human immunodeficiency virus-1 recombinant gp120 induces changes in protein kinase C isozymes--a preliminary report
    S Gupta
    Division of Basic and Clinical Immunology, University of California, Irvine 92717
    Int J Immunopharmacol 16:197-204. 1994
    ..The most striking change was observed in PKC-zeta isozymes levels. This study for the first time demonstrates that HIV-1 gp120 affects calcium-independent PKC isozymes in U937 cells...
  26. ncbi In vitro phosphorylation of human immunodeficiency virus type 1 Tat protein by protein kinase C: evidence for the phosphorylation of amino acid residue serine-46
    A M Holmes
    Biochemistry Department, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Arch Biochem Biophys 335:8-12. 1996
    ..Several Tat peptides, containing serine at position 46, are the only ones which are phosphorylated at significant rates. Several other Tat peptides containing potential protein kinase C phosphorylation sites are not phosphorylated...
  27. ncbi Inhibition of the c-Jun N-terminal kinase/AP-1 and NF-kappaB pathways by PICOT, a novel protein kinase C-interacting protein with a thioredoxin homology domain
    S Witte
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Biol Chem 275:1902-9. 2000
    ..These findings suggest that PICOT and its evolutionary conserved homologues may interact with PKC-related kinases in multiple organisms and, second, that it plays a role in regulating the function of the thioredoxin system...
  28. ncbi HIV-1 reverse transcriptase is phosphorylated in vitro and in a cellular system
    H Idriss
    Sealy Center for Molecular Science, The University of Texas Medical Branch Galveston, TX 77555 0851, USA
    Int J Biochem Cell Biol 31:1443-52. 1999
    ..Our results indicate that purified HIV-1 RT can be phosphorylated by several mammalian protein kinases in vitro and during expression in baculovirus infected insect cells...
  29. pmc The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway
    L Sanz
    Laboratorio Glaxo Wellcome CSIC de Biología Molecular y Celular, Centro de Biología Molecular Severo Ochoa Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid, Universidad Autonoma, Canto Blanco, 28049 Madrid, Spain
    EMBO J 19:1576-86. 2000
    ..Together, these results indicate that p62 is an important intermediary not only in TNFalpha but also in IL-1 signaling to NF-kappaB through the specific adapters RIP and TRAF6...
  30. ncbi A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1
    A Balendran
    MRC Protein Phosphorylation Unit, Division of Signal Transduction Therapy, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, United Kingdom
    J Biol Chem 275:20806-13. 2000
    ..These findings indicate that the hydrophobic motif of PRK2 and PKCzeta acts as a "docking site" enabling the recruitment of PDK1 to these substrates. This is essential for their phosphorylation by PDK1 in cells...
  31. pmc Tat protein of human immunodeficiency virus type 1 induces interleukin-10 in human peripheral blood monocytes: implication of protein kinase C-dependent pathway
    A Badou
    Laboratoire d Immuno Virologie EA3038, Universite Paul Sabatier, 31062 Toulouse Cedex, France
    J Virol 74:10551-62. 2000
    ..This production of IL-10 induced by Tat could participate in the progression of HIV infection to AIDS...
  32. ncbi Protein kinase C-zeta phosphorylates insulin receptor substrate-1 and impairs its ability to activate phosphatidylinositol 3-kinase in response to insulin
    L V Ravichandran
    Cardiology Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 276:3543-9. 2001
    ....
  33. ncbi Involvement of protein kinase C in HIV-1 gp120-induced apoptosis in primary endothelium
    M B Huang
    Department of Biochemistry, Morehouse School of Medicine, Atlanta, Georgia 30310 1495, USA
    J Acquir Immune Defic Syndr 25:375-89. 2000
    ....
  34. ncbi HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes
    I W Park
    Division of Experimental Medicine and Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, MA 02115, USA
    Blood 97:352-8. 2001
    ..These data indicate that the HIV-1 Tat protein may act as a protocytokine by causing the release of MCP-1 from the endothelial monolayer, and thereby facilitating monocyte transmigration into tissues via a PKC signaling pathway...
  35. ncbi HIV-1 Tat protein induces interleukin-10 in human peripheral blood monocytes: involvement of protein kinase C-betaII and -delta
    Yamina Bennasser
    Laboratoire d Immuno Virologie, EA 3038, Universite Paul Sabatier, 31062 Toulouse, France
    FASEB J 16:546-54. 2002
    ..Altogether, these results suggest that the induction of IL-10 by Tat is strictly dependent on the PKC-delta and -betaII isoforms...
  36. ncbi Regulation of IL-1 receptor-associated kinases by lipopolysaccharide
    Jean Hu
    Section of Infectious Diseases, Department of Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Immunol 168:3910-4. 2002
    ..In sharp contrast, we observe that the IRAK homolog, IRAK2, does not undergo degradation upon prolonged LPS treatment, suggesting complex regulation of the innate immunity network upon microbial challenge...
  37. ncbi Protein kinase C(mu) regulation of the JNK pathway is triggered via phosphoinositide-dependent kinase 1 and protein kinase C(epsilon)
    Ilona Brändlin
    Fraunhofer Institute for Interfacial Engineering, Nobelstrabetae 12, 70569 Stuttgart, Germany
    J Biol Chem 277:45451-7. 2002
    ..In this study, we show that differentially activated kinase cascades involving PDK1 and novel PKC isotypes are responsible for the regulation of PKC(mu) activity and consequently inhibit the JNK pathway...
  38. ncbi A critical role for PKC zeta in endothelin-1-induced uterine contractions at the end of pregnancy
    G Di Liberto
    Institut National de la Santé et de la Recherche Médicale U361, Pavillon Baudelocque, 75014 Paris, France
    Am J Physiol Cell Physiol 285:C599-607. 2003
    ..We found that treatment of myometrial cell lattices with an inhibitory peptide specific for PKC zeta or with an antisense against PKC zeta resulted in a significant loss of ET-1-induced contraction...
  39. ncbi Ki-1/57 interacts with RACK1 and is a substrate for the phosphorylation by phorbol 12-myristate 13-acetate-activated protein kinase C
    Flavia C Nery
    Centro de Biologia Molecular Estrutural, Laboratorio Nacional de Luz Sincrotron, Rua Giuseppe Máximo Scolfaro 10 000, C P 6192, 13084 971 Campinas, SP, Brasil
    J Biol Chem 279:11444-55. 2004
    ..These events associate Ki-1/57 with the RACK1/PKC pathway and may be important for the regulation of its cellular functions...
  40. ncbi Protein kinase C-zeta-induced phosphorylation of Ser318 in insulin receptor substrate-1 (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1
    Klaus Moeschel
    Department of Internal Medicine IV, Endocrinology, Metabolism, Pathobiochemistry and Clinical Chemistry, University Hospital Tubingen, D 72076 Tubingen, Germany
    J Biol Chem 279:25157-63. 2004
    ..These results, generated in BHK(IR) cells, suggest that phosphorylation of Ser(318) by PKC-zeta might contribute to the inhibitory effect of prolonged hyperinsulinemia on IRS-1 function...
  41. ncbi Protein kinase Czeta is up-regulated in osteoarthritic cartilage and is required for activation of NF-kappaB by tumor necrosis factor and interleukin-1 in articular chondrocytes
    Edward R LaVallie
    Departments of Biological Technologies and Women s Health and Musculoskeletal Biology, Wyeth Research, Cambridge, Massachusetts 02140 2325, USA
    J Biol Chem 281:24124-37. 2006
    ..These data implicate PKCzeta as a necessary component of the IL-1 and TNF signaling pathways in chondrocytes that result in catabolic destruction of extracellular matrix proteins in osteoarthritic cartilage...
  42. doi KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling
    Heidi N Hilton
    Development Group, Cancer Research Program, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia
    Biochim Biophys Acta 1783:383-93. 2008
    ..Thus KIBRA may play a role in how the reproductive state influences the mammary epithelial cell to respond to changing cell-context information, such as experienced during the tissue remodeling events of mammary gland development...
  43. pmc The membrane protein ATPase class I type 8B member 1 signals through protein kinase C zeta to activate the farnesoid X receptor
    Tamara Frankenberg
    Department of Pediatrics, Mount Sinai School of Medicine, New York, NY, USA
    Hepatology 48:1896-905. 2008
    ..and nuclear localization and its effects on BSEP promoter activity could be blocked with protein kinase C zeta (PKC zeta) inhibitors (pseudosubstrate or small interfering RNA silencing)...
  44. ncbi Regulation of HIV-1 gag protein subcellular targeting by protein kinase C
    G Yu
    Laboratory of Biological Chemistry, National Cancer Institute, NIH, Bethesda, Maryland 20892 4255
    J Biol Chem 270:4792-6. 1995
    ..This signal may provide a mechanism for the cellular regulation of virus development through modulation of gag protein-related developmental steps such as capsid targeting, assembly, encapsidation, budding, and maturation...
  45. ncbi Phosphorylation of HIV-1 gag proteins by protein kinase C
    B Burnette
    Laboratory of Biological Chemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 268:8698-703. 1993
    ..These data are consistent with the identification of a highly conserved consensus PKC phosphorylation site motif in the HIV-1 gag protein at Ser111 and suggests that PKC phosphorylation plays an important role in gag protein function...
  46. ncbi The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C
    M T Diaz-Meco
    Centro de Biología Molecular Consejo Superior de Investigaciones Cientificas Universidad Autónoma de Madrid
    Cell 86:777-86. 1996
    ..These findings support a role for the atypical PKC subspecies in the control of cell growth and survival...
  47. ncbi Nucleolin is a protein kinase C-zeta substrate. Connection between cell surface signaling and nucleus in PC12 cells
    G Zhou
    Department of Zoology, Auburn University, Auburn, Alabama 36849 5414, USA
    J Biol Chem 272:31130-7. 1997
    ..Taken together, the findings presented herein document that nucleolin is a target of PKC-zeta that serves to relay NGF signals from cell surface to nucleus in PC12 cells...
  48. ncbi Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1
    J A Le Good
    Protein Phosphorylation Laboratory, Imperial Cancer Research Fund, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Science 281:2042-5. 1998
    ..The activation loop phosphorylation of PKCdelta in response to serum stimulation of cells was PI 3-kinase-dependent and was enhanced by PDK1 coexpression...
  49. ncbi Regulation of protein kinase C zeta by PI 3-kinase and PDK-1
    M M Chou
    University of Pennsylvania School of Medicine, Department of Cell and Developmental Biology, Philadelphia 19104, USA
    Curr Biol 8:1069-77. 1998
    Protein kinase C zeta (PKC zeta) is a member of the PKC family of enzymes and is involved in a wide range of physiological processes including mitogenesis, protein synthesis, cell survival and transcriptional regulation...
  50. ncbi Protein kinase Czeta is a negative regulator of protein kinase B activity
    R P Doornbos
    Institute of Biomembranes, Department of Molecular Cell Biology, Utrecht University, 3584 CH Utrecht, The Netherlands
    J Biol Chem 274:8589-96. 1999
    ..In summary, our results demonstrate that PKB interacts with PKCzeta in vivo and that PKCzeta acts as a negative regulator of PKB...
  51. pmc Atypical protein kinases Clambda and -zeta associate with the GTP-binding protein Cdc42 and mediate stress fiber loss
    M P Coghlan
    Division of Signal Transduction, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Cell Biol 20:2880-9. 2000
    ..N17 Rac did not block Ras-induced loss of stress fibers, nor did kinase-dead PKClambda block V12 Rac-stimulated loss of stress fibers. These results indicate that Cdc42 and Rac use different pathways to regulate stress fibers...
  52. ncbi Activation of atypical protein kinase C zeta by caspase processing and degradation by the ubiquitin-proteasome system
    L Smith
    Department of Pharmacology and Toxicology, Schools of Medicine and Dentistry, University of Alabama at Birmingham, Alabama 35294, USA
    J Biol Chem 275:40620-7. 2000
    ..We conclude that caspases process PKCzeta to carboxyl-terminal fragments that are catalytically active and that are degraded by the ubiquitin-proteasome pathway...
  53. ncbi Protein kinase C zeta plays a central role in activation of the p42/44 mitogen-activated protein kinase by endotoxin in alveolar macrophages
    M M Monick
    Department of Medicine, University of Iowa College of Medicine and Veterans Administration Medical Center, Iowa City, IA, USA
    J Immunol 165:4632-9. 2000
    ..In this study, we evaluated the role of the atypical protein kinase C (PKC) isoform, PKC zeta, in LPS-induced activation of the ERK kinase pathway...
  54. ncbi Protein kinase C zeta phosphorylates a subset of selective sites of the NADPH oxidase component p47phox and participates in formyl peptide-mediated neutrophil respiratory burst
    P M Dang
    Institut National de la Santé et de la Recherche Médicale Unité 479, Centre Hospitalier Universitaire Xavier Bichat, Paris, France
    J Immunol 166:1206-13. 2001
    ..Protein kinase C zeta (PKC zeta), an atypical PKC isoform expressed abundantly in human polymorphonuclear leukocytes (PMN), translocates to the ..
  55. ncbi Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway
    M Leitges
    Max Planck Institut fur Experimentelle Endokrinologie, Feodor Lynen Str 7, 30625 Hannover, Germany
    Mol Cell 8:771-80. 2001
    ..Although in zetaPKC-/- EFs this kinase is not necessary for IKK activation, in lung, which abundantly expresses zetaPKC, IKK activation is inhibited...
  56. pmc Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activation
    Angeles Duran
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Canto Blanco, 28049 Madrid, Spain
    EMBO J 22:3910-8. 2003
    ..These results demonstrate the mechanism whereby zetaPKC regulates NF-kappaB activation in vivo...
  57. ncbi PKC zeta participates in activation of inflammatory response induced by enteropathogenic E. coli
    Suzana D Savkovic
    Section of Digestive Disease and Nutrition, Department of Medicine, University of Illinois, and West Side Department of Veterans Affairs Medical Center, Chicago, IL 60612, USA
    Am J Physiol Cell Physiol 285:C512-21. 2003
    ..kinases (ERKs) participate in EPEC-induced NF-kappa B activation but that other signaling molecules such as PKC zeta may be involved...
  58. ncbi Motility analysis of pancreatic adenocarcinoma cells reveals a role for the atypical zeta isoform of protein kinase C in cancer cell movement
    Carlo Laudanna
    Department of Pathology, University of Verona, Italy
    Lab Invest 83:1155-63. 2003
    ..These data suggest that the disregulation of the function of atypical zeta PKC might be involved in the acquisition of an invasive and metastatic phenotype in pancreatic adenocarcinoma cells...
  59. ncbi Protein kinase C zeta transactivates hypoxia-inducible factor alpha by promoting its association with p300 in renal cancer
    Kaustubh Datta
    Departmens of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Cancer Res 64:456-62. 2004
    ....
  60. ncbi Role of protein kinase Czeta in thrombin-induced endothelial permeability changes: inhibition by angiopoietin-1
    Xiaochun Li
    Vascular Biology Laboratory, Division of Human Immunology, Hanson Institute, Institute of Medical and Veterinary Science, Frome Road, Adelaide, South Australia 5000
    Blood 104:1716-24. 2004
    ....
  61. ncbi The low molecular weight GTPase RhoA and atypical protein kinase Czeta are required for TLR2-mediated gene transcription
    Nicole Teusch
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Immunol 173:507-14. 2004
    ..These results indicate that multiple GTPase-regulated pathways emerge from stimulated Toll receptors, controlling different aspects of NF-kappaB-mediated gene transcription...
  62. pmc Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activity
    Xiu Fen Liu
    Molecular Tumor Biology Section, Laboratory of Cell Biology, National Cancer Institute, Building 37, Room 2144, 37 Convent Dr, MSC 4255, Bethesda, MD 20892 4255, USA
    Mol Cell Biol 24:6665-75. 2004
    ..Together, these results suggest that ECT2 regulates the polarity complex Par6/Par3/PKCzeta and possibly plays a role in epithelial cell polarity...
  63. ncbi PKC-zeta is essential for endotoxin-induced macrophage activation
    Joseph Cuschieri
    Department of Surgery, University of Cincinnati, 231 Albert Sabin Way, ML 558, Cincinnati, OH 45267 0558, USA
    J Surg Res 121:76-83. 2004
    ..The aim of the current study was to further clarify the mechanism of LPS activation through the TLR4 receptor complex by examining the roles of the various isoforms of PKC...
  64. pmc Crosstalk between PKCzeta and the IL4/Stat6 pathway during T-cell-mediated hepatitis
    Angeles Duran
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Madrid, Spain
    EMBO J 23:4595-605. 2004
    ..In contrast, Par-4-/- mice have increased sensitivity to ConA-induced liver damage and IL-4 signaling. This unveils a novel and critical involvement of PKCzeta in the IL-4/Stat6 signaling pathway in vitro and in vivo...
  65. pmc Atypical PKC-zeta regulates SDF-1-mediated migration and development of human CD34+ progenitor cells
    Isabelle Petit
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    J Clin Invest 115:168-76. 2005
    ..Our results demonstrate a central role for PKC-zeta in SDF-1-dependent regulation of hematopoietic stem and progenitor cell motility and development...
  66. pmc Identification of 80K-H as a protein involved in GLUT4 vesicle trafficking
    Conrad P Hodgkinson
    School of Biological Sciences, University of Southampton, Biomedical Sciences Building, Bassett Crescent East, Southampton SO16 7PX, UK
    Biochem J 388:785-93. 2005
    ..The results suggest a model whereby insulin triggers the formation of a PKCzeta-80K-H-munc18c complex that enhances GLUT4 translocation to the plasma membrane...
  67. ncbi hMutS alpha is protected from ubiquitin-proteasome-dependent degradation by atypical protein kinase C zeta phosphorylation
    Hélène Hernandez-Pigeon
    INSERM U563, CPTP, Bat B, Pavillon Lefebvre, Place du Dr Baylac, CHU Purpan, BP 3028, 31024 Toulouse Cedex 3, France
    J Mol Biol 348:63-74. 2005
    ..Here, we provide evidence that the atypical PKC zeta regulates ubiquitination, degradation, and levels of hMutS alpha proteins...
  68. ncbi Atypical PKC-zeta and PKC-iota mediate opposing effects on MCF-7 Na+/K+ATPase activity
    Antonella Muscella
    Dipartimento di Scienze e Tecnologie Biologiche e Ambientali, Universita degli Studi di Lecce, Ecotekne, Via Provinciale per Monteroni, Lecce, Italy
    J Cell Physiol 205:278-85. 2005
    ..The effects of Ang II are opposite depending upon the presence of the serum-sensitive PKC-iota, with the inhibitory effect possibly due to the redistribution of sodium pump from plasma membrane to the inactive intracellular pool...
  69. ncbi Requirement of androgen-dependent activation of protein kinase Czeta for androgen-dependent cell proliferation in LNCaP Cells and its roles in transition to androgen-independent cells
    Takahiro Inoue
    Department of Urology, Kyoto University Graduate School of Medicine, 54 Kawaharacho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Mol Endocrinol 20:3053-69. 2006
    ..Our data suggest that protein kinase Czeta/mammalian target of rapamycin/S6 kinase pathway plays an important role for the transition of androgen-dependent to androgen-independent prostate cancer cells...
  70. ncbi Protein kinase Czeta abrogates the proapoptotic function of Bax through phosphorylation
    Meiguo Xin
    University of Florida Shands Cancer Center, Department of Medicine and Department of Anatomy and Cell Biology, University of Florida, Gainesville, Florida 32610 3633, USA
    J Biol Chem 282:21268-77. 2007
    ..Thus, PKCzeta may function as a physiological Bax kinase to directly phosphorylate and interact with Bax, which leads to sequestration of Bax in cytoplasm and abrogation of the proapoptotic function of Bax...
  71. doi Reduction of protein kinase C zeta inhibits migration and invasion of human glioblastoma cells
    Hua Guo
    Department of Core Laboratory, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
    J Neurochem 109:203-13. 2009
    ..Collectively, these findings suggest that PKCzeta is a potential therapeutic target for glioblastoma infiltration...
  72. doi Pivotal Advance: PKCzeta is required for migration of macrophages
    Hua Guo
    Research Center of Basic Medical Sciences and Cancer Institute and Hospital, Tianjin, 300060, China
    J Leukoc Biol 85:911-8. 2009
    ..Therefore, PKCzeta is required for CSF-1-induced chemotaxis of macrophages. Blocking activation of PKCzeta will be a novel strategy to inhibit cancer metastasis by blocking migration of cancer cells and macrophages...
  73. pmc RHOA and PRKCZ control different aspects of cell motility in pancreatic cancer metastatic clones
    Marco Della Peruta
    Department of Pathology, University of Verona, Strada Le Grazie 8, Verona, Italy
    Mol Cancer 9:61. 2010
    ....
  74. doi Activation by tyrosine phosphorylation as a prerequisite for protein kinase Cζ to mediate epidermal growth factor receptor signaling to ERK
    Christina Valkova
    Center of Molecular Biomedicine, Institute of Biochemistry and Biophysics, Friedrich Schiller University Jena, Hans Knöll Strasse 2, D 07745 Jena, Germany
    Mol Cancer Res 8:783-97. 2010
    ..This study characterizes PKCzeta as a novel mitogenic downstream mediator of EGFR and indicates PKCzeta as a therapeutic target in some carcinomas...
  75. doi Atypical protein kinase C zeta exhibits a proapoptotic function in ovarian cancer
    Irina Nazarenko
    Karlsruhe Institute of Technology, Institute of Toxicology and Genetics, Hermann von Helmholtz Platz 1, Eggenstein Leopoldshafen, Germany
    Mol Cancer Res 8:919-34. 2010
    ....
  76. pmc The prognostic impact of TGF-β1, fascin, NF-κB and PKC-ζ expression in soft tissue sarcomas
    Andrej Valkov
    Department of Clinical Pathology, University Hospital of Northern Norway, Tromsø, Norway
    PLoS ONE 6:e17507. 2011
    ..We aimed to investigate the prognostic impact of TGF-β1, NF-κB p105, PKC-ζ, Par-6α, E-cadherin and vimentin in non-gastrointestinal stromal tumor soft tissue sarcomas (non-GIST STSs)...
  77. ncbi Over-expression of protein kinase C isoforms (α, δ, θ and ζ) in squamous cervical cancer
    L R Yu
    Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Wenzhou Medical College, China
    Neoplasma 58:491-8. 2011
    ..05). These findings indicate that protein kinase C isoforms expression in cervical lesions was associated with carcinogenesis and might play important roles throughout the process of cervical cancer development...
  78. pmc HGF-induced PKCζ activation increases functional CXCR4 expression in human breast cancer cells
    Songyin Huang
    Department of Laboratory, Sun Yat Sen Memorial Hospital, Sun Yat Sen University, Guangzhou, China
    PLoS ONE 7:e29124. 2012
    ..Moreover, HGF may promote the invasiveness and metastasis of breast tumor xenografts in BALB/c-nu mice via the PKCζ-mediated pathway, while suppression of PKCζ by RNA interference may abrogate cancer cell spreading...
  79. doi MEK/ERK pathway mediates PKC activation-induced recruitment of PKCζ and MMP-9 to podosomes
    Helan Xiao
    Division of Cell and Molecular Biology, University Health Network Toronto General Research Institute, Toronto, Ontario, Canada
    J Cell Physiol 228:416-27. 2013
    ..We conclude that PKCζ may regulate MEK/ERK and JNK phosphorylation and in turn activated MEK/ERK and JNK may regulate the proteolytic activity of PDBu-induced podosomes by influencing the recruitment of PKCζ and MMP-9 to podosomes...
  80. ncbi Protein-protein interaction of zinc finger LIM domains with protein kinase C
    S Kuroda
    Biosignal Research Center, Kobe University, Kobe 657, Japan
    J Biol Chem 271:31029-32. 1996
    ..These results suggest that the LIM domain is one of the targets of PKC and that the LIM-PKC interaction may shed light on undefined roles of LIM domain-containing proteins...
  81. ncbi The bile acid taurochenodeoxycholate activates a phosphatidylinositol 3-kinase-dependent survival signaling cascade
    C Rust
    Division of Gastroenterology and Hepatology, Department of Oncology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 275:20210-6. 2000
    ..Collectively, these data suggest that some hydrophobic bile acids such as TCDC activate PI3K-dependent survival pathways, which prevent their otherwise inherent toxicity...
  82. ncbi Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C
    Y Noda
    Department of Molecular and Structural Biology, Kyushu University Graduate School of Medical Science, Fukuoka 812 8582, Japan
    Genes Cells 6:107-19. 2001
    ..However, little is known about a link between PAR proteins and the GTPases in cell polarization...
  83. ncbi Platelet P-selectin expression: requirement for protein kinase C, but not protein tyrosine kinase or phosphoinositide 3-kinase
    Danielle Libersan
    Montreal Heart Institute and the University of Montreal, Quebec, Canada
    Thromb Haemost 89:1016-23. 2003
    ..The novel epsilon and eta and atypical zeta, but not the conventional alpha and beta and the novel delta PKCs, may be involved in this process...
  84. pmc Protein kinase Czeta-dependent LKB1 serine 428 phosphorylation increases LKB1 nucleus export and apoptosis in endothelial cells
    Ping Song
    Section of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA
    J Biol Chem 283:12446-55. 2008
    ..Finally, ONOO(-) enhanced PKCzeta nuclear import and LKB1 nuclear export. We conclude that PKCzeta mediates LKB1-dependent Akt inhibition in response to ONOO(-), resulting in endothelial apoptosis...
  85. ncbi Protein Kinase-zeta inhibits collagen I-dependent and anchorage-independent growth and enhances apoptosis of human Caco-2 cells
    Reba Mustafi
    Department of Medicine, The University of Chicago Hospitals and Clinics, MC 4076, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Mol Cancer Res 4:683-94. 2006
    ..The observed down-regulation of this growth-suppressing PKC isoform in colonic carcinogenesis would be predicted to contribute to tumorigenesis...
  86. ncbi Ras, protein kinase C zeta, and I kappa B kinases 1 and 2 are downstream effectors of CD44 during the activation of NF-kappa B by hyaluronic acid fragments in T-24 carcinoma cells
    K A Fitzgerald
    Department of Biochemistry, Trinity College, Dublin, Ireland
    J Immunol 164:2053-63. 2000
    ..In particular, PKC zeta was required because transfection of cells with dominant negative PKC zeta blocked the effect of HA fragments on ..
  87. ncbi Okadaic acid inhibits insulin-induced glucose transport in fetal brown adipocytes in an Akt-independent and protein kinase C zeta-dependent manner
    A M Valverde
    , Centro Mixto CSIC/UCM, Facultad de Farmacia, Universidad Complutense, 28040, Madrid, Spain
    FEBS Lett 472:153-8. 2000
    ..suggest that downstream of PI 3-kinase, insulin signalling diverges into at least two independent pathways through Akt/PKB and PKC zeta, the PKC zeta pathway contributing to glucose transport induced by insulin in fetal brown adipocytes.
  88. pmc Activation of protein kinase C zeta induces serine phosphorylation of VAMP2 in the GLUT4 compartment and increases glucose transport in skeletal muscle
    L Braiman
    Faculty of Life Sciences, Gonda-Goldschmied Center, Bar-Ilan University, Ramat-Gan 52900, Israel
    Mol Cell Biol 21:7852-61. 2001
    ..In this study we investigated the roles of PKC zeta in insulin-stimulated glucose uptake and GLUT4 translocation in primary cultures of rat skeletal muscle...
  89. ncbi Human parainfluenza virus type 3 phosphoprotein: identification of serine 333 as the major site for PKC zeta phosphorylation
    C C Huntley
    Department of Molecular Biology, Research Institute, Cleveland Clinic Foundation, Ohio 44195, USA
    Virology 211:561-7. 1995
    ..bacterially expressed unphosphorylated P is labeled in vitro with either commercial PKC or purified recombinant PKC zeta P protein has one major phosphorylation site...
  90. ncbi Insulin and PIP3 activate PKC-zeta by mechanisms that are both dependent and independent of phosphorylation of activation loop (T410) and autophosphorylation (T560) sites
    M L Standaert
    J. A. Haley Veterans' Hospital Research Service, and Department of Internal Medicine, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    Biochemistry 40:249-55. 2001
    ....
  91. pmc PDGF induction of alpha 2 integrin gene expression is mediated by protein kinase C-zeta
    J Xu
    Department of Dermatology, School of Medicine, SUNY at Stony Brook 11794-8165, USA
    J Cell Biol 134:1301-11. 1996
    ..Therefore, we propose that PDGF-stimulatory pathway of alpha 2 integrin gene expression involves multiple cellular protein kinases, one of which is PKC-zeta...
  92. ncbi Insulin activates protein kinases C-zeta and C-lambda by an autophosphorylation-dependent mechanism and stimulates their translocation to GLUT4 vesicles and other membrane fractions in rat adipocytes
    M L Standaert
    J. A. Haley Veterans' Hospital Research Service and the Department of Internal Medicine, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    J Biol Chem 274:25308-16. 1999
    ....
  93. pmc Telomerase is regulated by protein kinase C-zeta in human nasopharyngeal cancer cells
    C C Yu
    Department of Molecular and Cellular Biology, Chang Gung University, Kwei-San, Tao-Yuan 333, Taiwan
    Biochem J 355:459-64. 2001
    ....
  94. ncbi The activation of PI 3-K and PKC zeta in PMA-induced differentiation of HL-60 cells
    M S Kim
    College of Pharmacy and Center of Oriental Medicinal Science, Wonkwang University, Iksan, 570-749, Chonbuk, South Korea
    Cancer Lett 171:79-85. 2001
    ..Members of the protein kinase C (PKC) family have been suggested to be one of the downstream targets of PI 3-K. PKC zeta is one of the atypical PKCs, non-diacylglycerol-responsive PKCs, and the activity was measured by the ability of ..
  95. ncbi Overexpression of protein kinase C-zeta isoform increases cyclooxygenase-2 and inducible nitric oxide synthase
    B W Miller
    Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    Am J Physiol 273:C130-6. 1997
    ..NIH/3T3 cells overexpressing PKC-zeta showed no change in morphology, PGE2 production, COX-2 expression, or iNOS expression at basal conditions. This suggests a role for PKC-zeta in the expression of these enzymes in mesangial cells...
  96. ncbi Regulation of nuclear factor kappa B transactivation. Implication of phosphatidylinositol 3-kinase and protein kinase C zeta in c-Rel activation by tumor necrosis factor alpha
    A G Martin
    Centro de Biologia Molecular "Severo Ochoa, , Cantoblanco, Madrid 28049, Spain
    J Biol Chem 276:15840-9. 2001
    ..Interestingly, those c-Rel mutants not only did not respond to TNFalpha but also acted as dominant negative forms of nuclear factor kappaB activation...
  97. ncbi Insulin stimulates NHE1 activity by sequential activation of phosphatidylinositol 3-kinase and protein kinase C zeta in human erythrocytes
    M Sauvage
    Laboratoire des Biomembranes et Messagers Cellulaires, , Orsay, France
    Eur J Biochem 267:955-62. 2000
    ..With a similar time-course, insulin also promoted both the translocation and activation of PKC zeta, but had no effect on PKC alpha...
  98. ncbi Ceramide-induced translocation of protein kinase C zeta in primary cultures of astrocytes
    I Galve-Roperh
    Department of Biochemistry and Molecular Biology I, Faculty of Biology, Complutense University, Madrid, Spain
    FEBS Lett 415:271-4. 1997
    ..Results thus show that stimulation of PKCzeta may be one of the intracellular events triggered by activation of the sphingomyelin pathway...
  99. ncbi Subcellular localization and translocation of protein kinase C isoforms zeta and epsilon in human peripheral blood lymphocytes
    C Keenan
    Department of Clinical Medicine, Trinity Centre for Health Sciences, Trinity College Dublin, St James's Hospital, Ireland
    Int Immunol 9:1431-9. 1997
    ..By contrast, PKC zeta is progressively lost from the cytoskeleton following activation with anti-CD3...
  100. ncbi Rat protein kinase c zeta gene contains alternative promoters for generation of dual transcripts with 5'-end heterogeneity
    B S Marshall
    Urologic Oncology Research Laboratory and George M. O'Brien Urology Research Center for Prostate Cancer, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
    DNA Cell Biol 19:707-19. 2000
    ..Two forms of PKC zeta RNA, with different 5' ends, have been reported...
  101. ncbi Interleukin-1beta-induced expression of protein kinase C (PKC)-delta and epsilon in NIH 3T3 cells
    C L Varley
    Cellular Signalling Group of the Department of Human Metabolism and Clinical Biochemistry, University of Sheffield Medical School, Beech Hill Road, Sheffield, S10 2RX, UK
    Cytokine 9:577-81. 1997
    ....

Research Grants52

  1. PKC zeta-Specific Inhibitors for Treatment of Methamphetamine Addiction
    Jiyong Hong; Fiscal Year: 2010
    ....
  2. Protein Kinase C (PKC) Zeta and the Pancreatic Beta Cell
    Adolfo Garcia-Ocana; Fiscal Year: 2012
    ..in the beta cell, we have shown that growth factors and nutrients such as glucose activate the atypical isoform PKC zeta (?). However, the role of this signaling pathway in the beta cell is still in its early infancy...
  3. PKC zeta as a Target for Ceramide
    Mark Kester; Fiscal Year: 2010
    ..Additionally, this proposal holds the promise of defining lipidomimetics suitable as therapeutics or screening tools for further drug discovery. ..
  4. NAOMI MIRIAM HAMBURG; Fiscal Year: 2014
    ..Activation of PKC2 may link the metabolic derangements of diabetes to endothelial insulin resistance and pro-inflammatory endothelial ..
  5. ADIPOCYTE PROTEIN SECRETION AND INSULIN ACTION
    Harvey Lodish; Fiscal Year: 2007
    ..The PI will introduce anti-sense constructs for Rab3A, Rab3D, caveolins 1, 2, and 3, PKC epsilon, PKC zeta, osteonectin, and adipocyte alpha3 VI collagen...
  6. Role of atypical PKCs in Pancreatic Tumor Growth and Metastasis
    Nicole R Murray; Fiscal Year: 2010
    ..Our lab and others have identified a requisite role for atypical protein kinase Cs (aPKCs), PKC iota (PKC?) and PKC zeta (PKC?) in oncogenic K-ras signaling in vitro and in vivo...
  7. Transporter Mechanism of Amphetamine Sensitization
    Rong Chen; Fiscal Year: 2011
    ..saline- treated mice and determine whether PKC2 plays a role;2) determine if repeated AMPH will alter SERT trafficking and enhance serotonin efflux, and whether or ..
  8. VALIDATING AND TARGETING LYSOPHOSPHATIDIC ACID ACYLTRANSFERASE-BETA IN CANCER
    Gregory Springett; Fiscal Year: 2013
    ..Therefore, this proposal advances the mission of the agency to translate our understanding of signaling molecules into new therapies. ..
  9. MICHAEL ARCHIBALD FARRAR; Fiscal Year: 2015
    ..in ALL, we crossed mice expressing a constitutively active STAT5b transgene (STAT5b-CA) to blnk+/-, btk-/-, pkc2-/-, or nf:b1-/- mice...
  10. Validation of MALDI-MS-based inhibitor screening technologies for cancer targets
    KENNETH DONALD GREIS; Fiscal Year: 2012
    ....
  11. Protein Kinase B and C in Head Injury
    Larry Jenkins; Fiscal Year: 2007
    ..2) The overall rate of protein synthesis (controlled by elF2) is reduced due to acute and chronic PKC zeta and GSK-3 inhibition of eIF2beta, and 3)That therapeutic modulation with mild hypothermia after pediatric TBI ..
  12. CXC Chemokines and HIV Pathogenesis
    DAVID MARKOVITZ; Fiscal Year: 2009
    ..A mechanistic understanding of the interactions between HIV and these C-X-C chemokines could lead to the development of new approaches to the treatment of patients infected with HIV. ..
  13. CHEMOATTRACTANT SIGNALING TO LEUKOCYTE INTEGRINS
    Eugene Butcher; Fiscal Year: 2001
    ..A role for chelerythrine-sensitive serine-threonine kinases, particularly PKC zeta, in rho-dependent activation of integrins will also be explored...
  14. NO TOXICITY: REDOX REGULATION OF LUNG CELL THIOREDOXIN
    Jawaharlal Patel; Fiscal Year: 2005
    ..abstract_text> ..
  15. MECHANISMS REGULATING AIRWAY MUSCLE GROWTH
    Reynold Panettieri; Fiscal Year: 2003
    ..These studies will define the mechanism by which agonists induce ASM cell growth such that new issues in the pathogenesis of asthma will be addressed and therapeutic measures to prevent these alterations can be developed. ..
  16. CYTOKINES, OXIDANTS, NEUTROPHILS AND LUNG INJURY
    ASRAR MALIK; Fiscal Year: 2005
    ..In addition, we have identified signaling pathways involving PKC zeta and PI3 kinase/Akt that may activate oxidant signaling via NADPH oxidase...
  17. Aging Vitamin E, and Immune Function in Aged
    Simin Meydani; Fiscal Year: 2007
    ..This, in turn, will help in designing practical nutritional interventions to reverse and/or delay the age-associated dysregulation of immune and inflammatory responses as well as diseases associated with it. ..
  18. PKC Isozymes In Hypoxia-Induced Fibroblast Proliferation
    Mita Das; Fiscal Year: 2009
    ..abstract_text> ..
  19. SIGNALING IN RENAL MESANGIAL CELLS BY CYTOKINES
    Aubrey Morrison; Fiscal Year: 2000
    ....
  20. LIPID REGULATED KINASES IN INSULIN ACTION
    Robert Farese; Fiscal Year: 2001
    ..3. Define the role of PI 3-kinase in insulin-induced activation of PKC-zeta. 4. Examine the roles of PKC-zeta and Rho in insulin-stimulated glucose transport. ..
  21. APOPTOTIC NEURAL SIGNALING PATHWAYS--AGING RELEVANCE
    Giulio Taglialatela; Fiscal Year: 2001
    ..Aim 3 will test whether PKC zeta activation or NF-kappa B translocation are signals common to both trk A and p75 receptors that are essential for ..
  22. Targeting the cysteine rich domain of protein kinase C
    Jong Yun; Fiscal Year: 2002
    ..To minimize interpretation problems, we have chosen to investigate PKC zeta (z) , which contains only one CRD...
  23. CERAMIDE SIGNALING IN CARDIAC ELECTROPHYSIOLOGY
    Shi Liu; Fiscal Year: 2003
    ..abstract_text> ..
  24. Protective Mechanism of an Anti-Inflammatory Herbal Mix
    Ali Banan; Fiscal Year: 2006
    ..abstract_text> ..
  25. EGF, Oxidants & Intestinal Barrier Integrity
    Ali Banan; Fiscal Year: 2006
    ..abstract_text> ..
  26. Potential novel regulation of PDK-1 by phosphorylation
    RAMON RIOJAS; Fiscal Year: 2005
    ..To further characterize the phosphorylation of PDK-1, I will: 1) identify the novel site(s) of phosphorylation on PDK-1 by PKCzeta; and 2) determine whether PKC zeta-mediated phosphorylation affects PDK-1 activity and function in cells.
  27. Ethanol and cholesterol homeostasis in the brain
    Marina Guizzetti; Fiscal Year: 2006
    ..abstract_text> ..
  28. Cellular Signaling Mechanisms in Macrophage Activation.
    Joseph Cuschieri; Fiscal Year: 2007
    ..Through an enhanced understanding of these mechanisms it is our goal that potential therapeutic targets may be discovered to regulate the inflammatory response following trauma/hemorrhage and ischemia/reperfusion. ..
  29. Role of Prostaglandins & Phospholipase A in melanocytes
    Glynis Scott; Fiscal Year: 2009
    ..We hypothesize that PG and phospholipases stimulate HM dendricity, MS transfer &pigmentation through different mechanisms that act synergistically to modulate cutaneous pigmentation following UVR. ..
  30. Role of EGFR in Viral Infected Lung Epithelial Cells
    Martha M Monick; Fiscal Year: 2010
    ..Completion of these studies will add to our understanding of mechanisms of RSV infection of airway epithelium and the role of targeted signaling pathways in the subsequent inflammation and life span of infected cells. ..
  31. Caveolin-1 and NO Regulate PMN-mediated Increases in Vascular Permeability
    Richard D Minshall; Fiscal Year: 2011
    ....
  32. Heme Oxygenase-Regulation, Function&Clinical Application
    MAHIN MAINES; Fiscal Year: 2003
    ....
  33. PROTEIN KINASE C IN ISCHEMIC RENAL INJURY AND REPAIR
    Babu Padanilam; Fiscal Year: 2002
    ..These observations will be extended to test the effects of various PKC activators and inhibitors on renal function, morphology, cell proliferation, apoptosis and differentiation post- ischemia. ..
  34. BONE FACTORS AND ENDOCHONDRAL OSSIFICATION
    Barbara Boyan; Fiscal Year: 2001
    ..It is suggested that these results will provide insight into the role these factors play in bone development and repair. ..
  35. INTERACTION OF HELICOBACTER PYLORI WITH PHAGOCYTES
    LEE ANN ALLEN; Fiscal Year: 2003
    ..A complete dissection of this process at the molecular level may lead to novel therapies for treatment of H. pylori infection and reduce the significant morbidity associated with ulcer disease. ..
  36. VTC Events Mediated by the Rab2 Complex
    Ellen J Tisdale; Fiscal Year: 2010
    ..The studies proposed in this application will develop a new and novel paradigm that couples Rab2-Apkc lA-GAPDH dysfunction with pathological consequences. ..
  37. MULTIPLE FORMS OF HEME OXYGENASE--REGULATION BY TOXINS
    MAHIN MAINES; Fiscal Year: 2001
    ..The nature of the second HO-2 immunoreactive protein in GC-treated rat testis also will be investigated. ..
  38. ROLE OF MEMBRANES AND MINERALIZATION OF BONES AND TEETH
    Barbara Boyan; Fiscal Year: 2001
    ..This work will have major implications for our understanding of MV and how cells that calcify their matrix are able to regulate these extracellular organelles at distant sites. ..
  39. Influence of Sex and Gender on Musculoskeletal Health
    Barbara Boyan; Fiscal Year: 2004
    ..Worldwide current and future clinical trials will be discussed. Short papers on the workshop topics, future directions, and scientific updates will be published via Internet and summary papers in peer-reviewed journals. ..
  40. PKD Family Kinases and Idiopathic Pulmonary Fibrosis
    Hua Tang; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  41. Tyrosine Phosphatases and Endothelial Dysfunction
    Hua Tang; Fiscal Year: 2004
    ..abstract_text> ..
  42. In vivo and ex vivo mechanisms related to eNOS uncoupling during reperfusion
    Lindon Young; Fiscal Year: 2008
    ..e., aerobic exercise) compared to more sedentary life-style after organ transplantation or heart attacks. [unreadable] [unreadable] [unreadable]..
  43. NeuroAIDS in Cameroon: Molecular determinants
    GEORGETTE KANMOGNE; Fiscal Year: 2008
    ..It will provide knowledge on the epidemiology of neuroAIDS in Cameroon and build the capacity for future neuroAIDS research and therapeutic testing in Cameroon. [unreadable] [unreadable] [unreadable]..
  44. Molecular Mechanisms That Regulate CD11d Expression
    JOHN NOTI; Fiscal Year: 2004
    ..Transgenic analysis of the CD11d cis elements will be done to complement these studies. These studies will expand our understanding of normal myeloid development and leukemogenesis. ..
  45. Zeiss Dynamic Laser TIRF
    Richard Minshall; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  46. HIV-1 gp120-induced Endothelial Cell Dysfunction
    GEORGETTE KANMOGNE; Fiscal Year: 2007
    ....
  47. Development of Hydrogel Spinal Disc Replacement
    Barbara Boyan; Fiscal Year: 2004
    ..abstract_text> ..
  48. Modulation of K channels in renal collecting duct
    Wen Hui Wang; Fiscal Year: 2007
    ....
  49. beta-Catenin/NF-kappaBeta and Colon Cancer
    Shahid Umar; Fiscal Year: 2004
    ..By studying a mechanistic basis of NF-kappaB and beta-catenin mediated increases in cell census, in the absence and presence of chronic inflammation, we may identify new treatment strategies for reducing cancer risk. ..
  50. Role of Par Genes in the Early Mouse Embryo
    VERNADETH ALARCON; Fiscal Year: 2006
    ..An understanding of cell polarization in the mouse embryo should have significant benefit for human health research related to reproductive problems. ..
  51. Programming of gene expression during fetal life
    S Ozanne; Fiscal Year: 2005
    ....
  52. Protective Role of Heme Oxygenase in Ischemic Brain
    MAHIN MAINES; Fiscal Year: 2005
    ..Genes will be delivered by CSF or by intracarotid route and the same indeces will be evaluated. ..