PISSLRE

Summary

Gene Symbol: PISSLRE
Description: cyclin dependent kinase 10
Alias: PISSLRE, cyclin-dependent kinase 10, CDC2-related protein kinase, cell division protein kinase 10, cyclin-dependent kinase (CDC2-like) 10, cyclin-dependent kinase related protein, serine/threonine protein kinase PISSLRE
Species: human

Top Publications

  1. pmc A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation
    Jiali Han
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 4:e1000074. 2008
  2. doi Identification of CDK10 as an important determinant of resistance to endocrine therapy for breast cancer
    Elizabeth Iorns
    The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK
    Cancer Cell 13:91-104. 2008
  3. ncbi The cdc-2-related kinase, PISSLRE, is essential for cell growth and acts in G2 phase of the cell cycle
    S Li
    Jefferson Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 55:3992-5. 1995
  4. pmc Genome-wide association study identifies three loci associated with melanoma risk
    D Timothy Bishop
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Cancer Research UK Clinical Centre at Leeds, St James s University Hospital, Leeds, UK
    Nat Genet 41:920-5. 2009
  5. ncbi CDK10 is not a target for aberrant DNA methylation in breast cancer
    Gerwin Heller
    Department of Medicine I, Medical University of Vienna, Borschkegasse 8a, A 1090 Vienna, Austria
    Anticancer Res 29:3939-44. 2009
  6. ncbi Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer
    F Bullrich
    Jefferson Cancer Insititute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107
    Cancer Res 55:1199-205. 1995
  7. ncbi Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity
    M Kasten
    Department of Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania, PA 19107, USA
    Oncogene 20:1832-8. 2001
  8. pmc Cyclin G2 promotes cell cycle arrest in breast cancer cells responding to fulvestrant and metformin and correlates with patient survival
    Maike Zimmermann
    a Department of Pharmacology, University of California, Davis, CA, USA
    Cell Cycle 15:3278-3295. 2016
  9. ncbi Functions of CRK1 Gene of Candida albicans as Studied by Gene Knock-out
    Qin Wang
    State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry, The Chinese Academy of Sciences, Shanghai 200031, China
    Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 31:545-552. 1999
  10. pmc CDKG1 protein kinase is essential for synapsis and male meiosis at high ambient temperature in Arabidopsis thaliana
    Tao Zheng
    John Innes Centre, Norwich NR4 7UH, United Kingdom
    Proc Natl Acad Sci U S A 111:2182-7. 2014

Research Grants

  1. Transcriptional regulation by protein kinase CDC2L5
    JASPER YIK; Fiscal Year: 2006
  2. Mechanisms of Cone Pigment Deactivation
    Cheryl Craft; Fiscal Year: 2009

Scientific Experts

  • Jiang-Ye Chen
  • Leandros A Skaltsounis
  • Yanjie You
  • Charles Swanton
  • D Timothy Bishop
  • Minoru Toyota
  • C J Lord
  • S A Whitmore
  • John T Seykora
  • Cheryl Craft
  • Michael Hilker
  • A E Chambers
  • Jingui Li
  • M Machida
  • JASPER YIK
  • Helga Gomes
  • Xiang Yu Zhong
  • Jian Hua Yu
  • Jiali Han
  • Weiwei Zhang
  • Maike Zimmermann
  • Mei Han Liu
  • Yinü Li
  • Kyriaki Antonopoulou
  • Chao qun Hong
  • Arang Rhie
  • Tao Zheng
  • Tingting Sun
  • Masayoshi Isezaki
  • Carlos Logullo
  • Kazuhiko Ohashi
  • Antonia Efstathiou
  • Itabajara da Silva Vaz
  • Wen Liu
  • Satoru Konnai
  • Jorge Moraes
  • Naftaly Githaka
  • Vincent J Guen
  • Yankun Gao
  • Chi Wei Yeh
  • P Khanal
  • Jian Ni
  • Stephanie Bacopulos
  • Yun fu Cui
  • Jens U Marquardt
  • Sheng Tai
  • Ying Liu
  • Zhi Dong Wang
  • Jennifer H Barrett
  • Laura A T Cleghorn
  • Grant W Montgomery
  • Nicholas G Martin
  • Nicholas K Hayward
  • Eddy S Leman
  • Gerwin Heller
  • Aline Dubos
  • Elizabeth Iorns
  • Walter Paper
  • Luigi Bagella
  • Hung Hsi Chen
  • Yiguo Wang
  • Ziyue Niu
  • Miao Sun
  • Jianxin Gu
  • Wei Wang
  • Jialin Cheng
  • Lianxin Zhu
  • Sunil Singhal
  • Shao Min Shi
  • Wenjuan Chen
  • Xiaofeng Shi
  • Tommaso Patriarchi
  • Zhifang Zhang
  • Michaela S Donaldson
  • Qinghua Xi
  • Aimin Li
  • Kai Li
  • Yan Deng
  • Jianxin Zhong
  • Rong Liu
  • Mary C Horne
  • Shumin Lü
  • Yannan Chen
  • Xingjian Liu
  • Chunhui Tang
  • En Qi Chen
  • Aruni P S Arachchige-Don
  • Huipeng Yang
  • Feng Jiang
  • Katerina P Kypreou

Detail Information

Publications76

  1. pmc A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation
    Jiali Han
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 4:e1000074. 2008
    ..The signals detected in a region around the MC1R gene were explained by MC1R red hair color alleles. Our results suggest that the IRF4 and SLC24A4 loci are associated with human hair color and skin pigmentation...
  2. doi Identification of CDK10 as an important determinant of resistance to endocrine therapy for breast cancer
    Elizabeth Iorns
    The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK
    Cancer Cell 13:91-104. 2008
    ..The association of low levels of CDK10 with methylation of the CDK10 promoter suggests a mechanism by which CDK10 expression is reduced in tumors...
  3. ncbi The cdc-2-related kinase, PISSLRE, is essential for cell growth and acts in G2 phase of the cell cycle
    S Li
    Jefferson Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 55:3992-5. 1995
    ..Recently, a new cdc2-related protein kinase has been discovered. PISSLRE, named with respect to its homology to the cdc2 PSTAIRE amino acid domain...
  4. pmc Genome-wide association study identifies three loci associated with melanoma risk
    D Timothy Bishop
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Cancer Research UK Clinical Centre at Leeds, St James s University Hospital, Leeds, UK
    Nat Genet 41:920-5. 2009
    ..Despite wide variation in allele frequency, these genetic variants show notable homogeneity of effect across populations of European ancestry living at different latitudes and show independent association to disease risk...
  5. ncbi CDK10 is not a target for aberrant DNA methylation in breast cancer
    Gerwin Heller
    Department of Medicine I, Medical University of Vienna, Borschkegasse 8a, A 1090 Vienna, Austria
    Anticancer Res 29:3939-44. 2009
    ..Loss of cyclin-dependent kinase (CDK) 10 expression may be an important mechanism of tamoxifen resistance and the 5' CpG island associated with the CDK10 gene has been suggested to be a target for aberrant methylation in breast cancer...
  6. ncbi Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer
    F Bullrich
    Jefferson Cancer Insititute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107
    Cancer Res 55:1199-205. 1995
    ..Here we report the chromosomal mapping of two cdks, cdk3 and cdk6, two putative cdks, PISSLRE and PITALRE, and one cyclin-dependent kinase inhibitor, p27, to chromosomal regions which may be altered in human ..
  7. ncbi Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity
    M Kasten
    Department of Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania, PA 19107, USA
    Oncogene 20:1832-8. 2001
    ..We find that Cdk10 binds full length Ets2 in vitro and in vivo and inhibits Ets2 transactivation in mammalian cells...
  8. pmc Cyclin G2 promotes cell cycle arrest in breast cancer cells responding to fulvestrant and metformin and correlates with patient survival
    Maike Zimmermann
    a Department of Pharmacology, University of California, Davis, CA, USA
    Cell Cycle 15:3278-3295. 2016
    ..Together these findings indicate that CycG2 contributes to signaling networks that limit BC...
  9. ncbi Functions of CRK1 Gene of Candida albicans as Studied by Gene Knock-out
    Qin Wang
    State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry, The Chinese Academy of Sciences, Shanghai 200031, China
    Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 31:545-552. 1999
    ..The Crk1p might promote the invasive growth or cell elongation through a route different from the MAPK signal transduction pathway...
  10. pmc CDKG1 protein kinase is essential for synapsis and male meiosis at high ambient temperature in Arabidopsis thaliana
    Tao Zheng
    John Innes Centre, Norwich NR4 7UH, United Kingdom
    Proc Natl Acad Sci U S A 111:2182-7. 2014
    ....
  11. doi In a nongenomic action, steroid hormone 20-hydroxyecdysone induces phosphorylation of cyclin-dependent kinase 10 to promote gene transcription
    Wen Liu
    The Key Laboratory of Plant Cell Engineering and Germplasm Innovation, Ministry of Education, Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Science, Shandong University, Jinan 250100, China
    Endocrinology 155:1738-50. 2014
    ..CDK10 depletion suppressed the formation of the Hsps-EcRB1 complex at the hormone receptor 3 promoter. These results suggest that 20E induces CDK10 phosphorylation via a nongenomic pathway to regulate gene transcription in the nucleus...
  12. doi PFTK1 interacts with cyclin Y to activate non-canonical Wnt signaling in hepatocellular carcinoma
    Tingting Sun
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Biochem Biophys Res Commun 449:163-8. 2014
    ..In line with Rho GTPases activation, we also found marked actin polymerizations in cells with PFTK1-CCNY co-expressions. Our findings highlight a PFTK1-CCNY complex in activating noncanonical Wnt signaling in HCC cells. ..
  13. doi Updated field synopsis and systematic meta-analyses of genetic association studies in cutaneous melanoma: the MelGene database
    Kyriaki Antonopoulou
    Department of Dermatology, University of Athens School of Medicine, Andreas Sygros Hospital, Athens, Greece
    J Invest Dermatol 135:1074-9. 2015
    ..Our approach serves as a useful model in analyzing and integrating the reported germline alterations involved in CM. ..
  14. pmc An inhibitor-driven study for enhancing the selectivity of indirubin derivatives towards leishmanial Glycogen Synthase Kinase-3 over leishmanial cdc2-related protein kinase 3
    Antonia Efstathiou
    Laboratories of Pharmacognosy and Pharmaceutical Chemistry, Department of Pharmacy, University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece
    Parasit Vectors 7:234. 2014
    ....
  15. doi Identification and Characterization of the Cyclin-Dependent Kinases Gene Family in Silkworm, Bombyx mori
    Yinü Li
    Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing, China
    DNA Cell Biol 35:13-23. 2016
    ..It was shown from the RNAi experiments that the silencing of CDK1, CDK10, CDK12, and CDC2L1 could influence the cells from G0/G1 to S phase transition. ..
  16. pmc Genomic Copy Number Variations Characterize the Prognosis of Both P16-Positive and P16-Negative Oropharyngeal Squamous Cell Carcinoma After Curative Resection
    Arang Rhie
    From the Department of Biomedical Science, Department of Biochemistry and Molecular Biology, Genomic Medicine Institute GMI, Medical Research Center, Seoul National University, Seoul AR, J IIK Department of Pathology, Center for Specific Organs Cancer, Hematologic Malignancy Branch, National Cancer Center, Goyang, Gyeonggi WSP, MKC and Department of Otolaryngology Head and Neck Surgery, Graduate School of Cancer Science and Policy, Specific Organs Cancer Branch, National Cancer Center, Goyang, Gyeonggi, Korea J HK, Jr, CHR, Y SJ
    Medicine (Baltimore) 94:e2187. 2015
    ..Specific patterns of CNVs predict better survival, especially in p16+ OSCC. This might allow better insights of the outcome after curative resection for HPV+ and HPV- OSCC...
  17. doi Decreased CDK10 expression correlates with lymph node metastasis and predicts poor outcome in breast cancer patients - a short report
    Yanjie You
    Pathological Examination and Research Center, Luohe Medical College, 148 Daxue Road, Luohe, 462002, China
    Cell Oncol (Dordr) 38:485-91. 2015
    ..Here, we examined the expression status of CDK10 in a panel of primary human breast cancers and evaluated its correlation with clinicopathological parameters and clinical outcome...
  18. doi PFTK1 regulates cell proliferation, migration and invasion in epithelial ovarian cancer
    Weiwei Zhang
    Department of Obstetrics and Gynecology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, People s Republic of China
    Int J Biol Macromol 85:405-16. 2016
    ..Taken together, our study suggested that PFTK1 played an important role in ovarian cancer development. ..
  19. doi Knockdown of PFTK1 Expression by RNAi Inhibits the Proliferation and Invasion of Human Non-Small Lung Adenocarcinoma Cells
    Mei Han Liu
    Department of Ultrasonography, China Japan Union Hospital of Jilin University, Changchun, Jilin Province, China
    Oncol Res 24:181-7. 2016
    ..Therefore, PFTK1 may represent a novel therapeutic target for the treatment of NSCLC. ..
  20. pmc Elevated C1orf63 expression is correlated with CDK10 and predicts better outcome for advanced breast cancers: a retrospective study
    Chao qun Hong
    Guangdong Provincial Key Laboratory for Breast Cancer Diagnosis and Treatment, Cancer Hospital of Shantou University Medical College, Shantou, 515041, China
    BMC Cancer 15:548. 2015
    ..Here we investigated the expression and clinical implication of C1orf63 in breast cancer...
  21. doi Vaccination with cyclin-dependent kinase tick antigen confers protection against Ixodes infestation
    Helga Gomes
    Laboratório Integrado de Bioquímica Hatisaburo Masuda, NUPEM UFRJ, Campus Macaé, Avenida São José do Barreto, São José do Barreto, Macaé, RJ CEP 27971 220, Brazil Electronic address
    Vet Parasitol 211:266-73. 2015
    ..These findings may underpin the development of more efficacious anti-tick vaccines based on the targeting of cell cycle control proteins. ..
  22. doi Promoter hypermethylation contributes to the frequent suppression of the CDK10 gene in human nasopharyngeal carcinomas
    Yanjie You
    Department of Pharmacy, Luohe Medical College, 148 Daxue Road, Luohe 462002, China
    Cell Oncol (Dordr) 36:323-31. 2013
    ..Here we provide evidence that down-regulation of the CDK10 gene is mediated by promoter hypermethylation in primary human nasopharyngeal carcinomas (NPC) and NPC-derived cell lines...
  23. pmc Knockdown of cyclin-dependent kinase 10 (cdk10) gene impairs neural progenitor survival via modulation of raf1a gene expression
    Chi Wei Yeh
    From the Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung City 40201, Taiwan
    J Biol Chem 288:27927-39. 2013
    ..Our findings provide the first functional characterization of cdk10 in vertebrate development and reveal its critical function in neurogenesis by modulation of raf1a expression. ..
  24. pmc Identification and structural-functional analysis of cyclin-dependent kinases of the cattle tick Rhipicephalus (Boophilus) microplus
    Helga Gomes
    Laboratório Integrado de Bioquímica Hatisaburo Masuda, NUPEM UFRJ, Campus Macaé, Avenida São José do Barreto, São José do Barreto, Macaé, RJ, Brazil Instituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro, CCS, Bloco H, Cidade Universitaria, Ilha do Fundao, Rio de Janeiro, RJ, Brazil
    PLoS ONE 8:e76128. 2013
    ....
  25. ncbi Proteomic analysis reveals novel molecules involved in insulin signaling pathway
    Yiguo Wang
    Key Laboratory of Proteomics, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    J Proteome Res 5:846-55. 2006
    ..Our results imply CASK as a novel joint knot connecting CASK-mediated pathways with the insulin signaling. Our data provide a wealth of information potentially paving the way to identify new components in the insulin signaling network...
  26. pmc CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome
    Vincent J Guen
    P2I2 Group, Protein Phosphorylation and Human Disease Unit, Station Biologique, Centre National de la Recherche Scientifique CNRS, Unité de Service et de Recherche USR3151, 29680 Roscoff, France
    Proc Natl Acad Sci U S A 110:19525-30. 2013
    ..Altogether, our results reveal an additional regulatory mechanism for ETS2, which plays key roles in cancer and development. They also shed light on the molecular mechanisms underlying STAR syndrome. ..
  27. ncbi Homology modeling and docking study of cyclin-dependent kinase (CDK) 10
    Miao Sun
    Institute of Theoretical Chemistry, State Key Laboratory of Theoretical and Computational Chemistry, Jilin University, Changchun, PR China
    Bioorg Med Chem Lett 15:2851-6. 2005
    ..The hydrogen bonding interactions also play an important role for the stability of the complex. Our results may be helpful for further experimental investigations...
  28. ncbi Alterations in cell cycle genes in early stage lung adenocarcinoma identified by expression profiling
    Sunil Singhal
    Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cancer Biol Ther 2:291-8. 2003
    ..e., cdc2, cullin 4A, ZAC, p57, DP-1, GADD45, PISSLRE, cdc20) nor in any other tumors (i.e., cyclin F, cullin 5, p34)...
  29. ncbi Candida albicans Cdc37 interacts with the Crk1 kinase and is required for Crk1 production
    Jian Ni
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, PR China
    FEBS Lett 561:223-30. 2004
    ..albicans. In support of this, CaSTI1 was identified from a two-hybrid screen with the full-length Crk1 as the bait. CaSti1 showed two-hybrid interactions with both Crk1 and the CaCdc37...
  30. doi Proyl isomerase Pin1 facilitates ubiquitin-mediated degradation of cyclin-dependent kinase 10 to induce tamoxifen resistance in breast cancer cells
    P Khanal
    BK21 Project Team, College of Pharmacy, Chosun University, Gwangju, Republic of Korea
    Oncogene 31:3845-56. 2012
    ..On the basis of these findings, we suggest that the Pin1-mediated CDK10 ubiquitination is a major regulator of tamoxifen-resistant breast cancer cell growth and survival...
  31. pmc Genome-wide association study identifies three new melanoma susceptibility loci
    Jennifer H Barrett
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Leeds Cancer Research UK Centre, St James s University Hospital, Leeds, UK
    Nat Genet 43:1108-13. 2011
    ..6 × 10(-7) under a fixed-effects model and P = 1.2 × 10(-3) under a random-effects model). These newly associated variants showed no association with nevus or pigmentation phenotypes in a large British case-control series...
  32. pmc CDK10 functions as a tumor suppressor gene and regulates survivability of biliary tract cancer cells
    Jian Hua Yu
    Department of Hepato pancreatobiliary Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin 150086, PR China
    Oncol Rep 27:1266-76. 2012
    ..Our results indicate that CDK10 plays a crucial role in the growth and survivability of biliary tract cancer, and offers a potential therapeutic target for this fatal disease...
  33. ncbi Gene expression profiling of follicular lymphoma and normal germinal center B cells using cDNA arrays
    Herve Husson
    Department of Medicine, Harvard Medical School, Boston, MA, USA
    Blood 99:282-9. 2002
    ..These findings provide a basis for future studies into the pathogenesis and pathophysiology of FL and may lead to the identification of potential therapeutic targets as well as antigens for immunotherapeutic strategies...
  34. doi Effects of the cyclin-dependent kinase 10 (CDK10) on the tamoxifen sensitivity of keloid samples
    Ying Liu
    Department of Plastic and Aesthetic, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China
    Molecules 17:1307-18. 2012
    ..The results suggested that CDK10 may play an important role in enhancement of tamoxifen efficiency, and its expression may have a synergistic effect on keloid treatments...
  35. pmc Effects of partner proteins on BCA2 RING ligase activity
    Stephanie Bacopulos
    Sunnybrook Research Institute, Toronto, ON, Canada
    BMC Cancer 12:63. 2012
    ..We have demonstrated previously that the RING E3 ligase BCA2 has autoubiquitination activity and is a very unstable protein. Previously, only Rab7, tetherin, ubiquitin and UBC9 were known to directly interact with BCA2...
  36. doi Clinical and biological significance of Cdk10 in hepatocellular carcinoma
    Xiang Yu Zhong
    Department of Hepatopancreatobiliary Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China
    Gene 498:68-74. 2012
    ..These data collectively demonstrate that reduced Cdk10 expression is closely linked to HCC development and progression. Restoration of its expression may have therapeutic benefits in treating this malignancy...
  37. pmc Loss of c-Met accelerates development of liver fibrosis in response to CCl(4) exposure through deregulation of multiple molecular pathways
    Jens U Marquardt
    Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Biochim Biophys Acta 1822:942-51. 2012
    ....
  38. pmc Identification of inhibitors of the Leishmania cdc2-related protein kinase CRK3
    Laura A T Cleghorn
    Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee, Dundee, DD1 5EH, UK
    ChemMedChem 6:2214-24. 2011
    ..The optimisation of these series using classical SAR studies afforded low-nanomolar CRK3 inhibitors with significant selectivity over the closely related human cyclin dependent kinase CDK2...
  39. doi Inhibitory effect of S-nitroso-glutathione on Eimeria tenella oocysts was mainly limited to the early stages of sporogony
    Jingui Li
    School of Veterinary Medicine, Yangzhou University, Yangzhou 225009, PR China jingui
    Vet Parasitol 173:64-9. 2010
    ..tenella oocysts could not be inactivated in vitro by GSNO. The inhibiting action of GSNO on oocysts was mainly limited to the early stages of sporulation, and this may partially associate with the inhibition of EtCRK2 mRNA expression...
  40. doi Identification of nuclear structural protein alterations associated with seminomas
    Eddy S Leman
    The Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Cell Biochem 108:1274-9. 2009
    ..In the non-seminoma tissues, one of the identified proteins appears to be cell division protein kinase 10 (CDK10)...
  41. doi Cancer epigenomics: implications of DNA methylation in personalized cancer therapy
    Minoru Toyota
    Department of Biochemistry, Cancer Research Institute, Sapporo Medical University, Sapporo 060 8556, Japan
    Cancer Sci 100:787-91. 2009
    ..However, the comprehensive study of pharmacoepigenomics awaits the advent of genome-wide analysis of DNA methylation using microarrays and next-generation sequencers...
  42. ncbi Dissecting resistance to endocrine therapy in breast cancer
    Christopher J Lord
    The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom
    Cell Cycle 7:1895-8. 2008
    ..The results of a high-throughput RNA interference screen identifying novel determinants of tamoxifen resistance support this conjecture and demonstrate that such approaches can identify clinically relevant genes, such as CDK10...
  43. pmc Elevated amounts of myocilin in the aqueous humor of transgenic mice cause significant changes in ocular gene expression
    Walter Paper
    Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany
    Exp Eye Res 87:257-67. 2008
    ..Our findings support a role for myocilin in modulating cellular adhesion, and suggest functional processes that involve other proteins of the olfactomedin family...
  44. ncbi Identification of murine cdk10: association with Ets2 transcription factor and effects on the cell cycle
    Luigi Bagella
    Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    J Cell Biochem 99:978-85. 2006
    ..the canonical regulatory Tyr and Thr residues present in all protein kinases and a PSTAIRE-like motif named PISSLRE. Although little is known about this protein, human cdk10 has been shown to encode two different isoforms, each ..
  45. ncbi The PISSLRE gene: structure, exon skipping, and exclusion as tumor suppressor in breast cancer
    J Crawford
    Department of Cytogenetics and Molecular Genetics, Adelaide Women s and Children s Hospital, North Adelaide, South Australia, 5006, Australia
    Genomics 56:90-7. 1999
    ..3. Among the genes mapped to this region, PISSLRE is a plausible candidate tumor suppressor gene...
  46. pmc p40MO15, a cdc2-related protein kinase involved in negative regulation of meiotic maturation of Xenopus oocytes
    J Shuttleworth
    School of Biochemistry, University of Birmingham, UK
    EMBO J 9:3233-40. 1990
    ..This effect can be reversed by subsequent injection of synthetic MO15 mRNA. These results suggest that p40MO15 is involved in negatively regulating meiosis...
  47. ncbi Physical linkage of the cdc2-related gene (PCTK1) and the ubiquitin-activating enzyme E1 gene (UBE1) on human Xp11.3
    J C Knight
    Department of Histopathology, UMDS, St Thomas Hospital, London, England
    Cytogenet Cell Genet 71:155-7. 1995
    ..3, indicating close physical linkage of these genes. PCTK1 is a new candidate for heritable disorders mapped to Xp11.3--p11.23 region...
  48. ncbi Cloning of a full-length cDNA sequence encoding a cdc2-related protein kinase from human endothelial cells
    J L Best
    Department of Inflammation Autoimmune Diseases, Hoffmann La Roche Inc, Nutley, NJ 07110
    Biochem Biophys Res Commun 208:562-8. 1995
    ..C-2k may therefore represent a new member of the cdc2 kinase family...
  49. ncbi Expression of CDK5 (PSSALRE kinase), a neural cdc2-related protein kinase, in the mature and developing mouse central and peripheral nervous systems
    H Ino
    Department of Anatomy, Chiba University School of Medicine, Japan
    Brain Res 661:196-206. 1994
    ..The expression pattern of CDK5 is quite in contrast with that of CDC2. The fact that CDK5 is expressed in terminally differentiated non-dividing neurons predicts an alternative function(s) in addition to controlling the cell cycle...
  50. ncbi Molecular cloning of PISSLRE, a novel putative member of the cdk family of protein serine/threonine kinases
    R Brambilla
    European Molecular Biology Laboratory, Heidelberg, Germany
    Oncogene 9:3037-41. 1994
    ..One clone isolated from the bladder carcinoma cell line RT112 encodes a novel protein kinase named PISSLRE, based on its predicted sequence at the conserved PSTAIRE motif...
  51. pmc PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro
    X Grana
    Fels Institute for Cancer Research and Molecular Biology, Department of Pathology, Temple University, School of Medicine, Philadelphia, PA 19140
    Proc Natl Acad Sci U S A 91:3834-8. 1994
    ..Interestingly, the retinoblastoma kinase activity associated with PITALRE does not oscillate during the cell cycle...
  52. ncbi Identification of a novel Drosophila gene encoding a Cdc2-related protein kinase
    R Sugaya
    Department of Biophysics and Biochemistry, Faculty of Science, University of Tokyo
    J Biochem 115:150-5. 1994
    ..Moreover, a whole mount in situ hybridization experiment showed that the Dcdrk mRNA is ubiquitously distributed in almost all embryonic cells and tissues, suggesting a universal function of Dcdrk, possibly in cell cycle regulation...
  53. ncbi Alternative splicing of human cyclin E
    A Sewing
    Institut für Molekularbiologie und Tumorforschung IMT, Philipps Universitat Marburg, Germany
    J Cell Sci 107:581-8. 1994
    ..cerevisiae. Cyclin Es is the first splice variant of a cell cycle regulatory protein to be described. Our findings also indicate that the cyclin box in cyclin E mediates the interaction with cdk2...
  54. ncbi PISSLRE, a human novel CDC2-related protein kinase
    X Grana
    Fels Institute for Cancer Research and Molecular Biology, Dept of Pathology, Temple University School of Medicine, Philadelphia, PA 19140
    Oncogene 9:2097-103. 1994
    ..sequence showed it to contain the XI subdomains present in all known protein kinases and a PSTAIRE-like motive, PISSLRE, which temporarily names this kinase...
  55. pmc The cdc2-related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2
    R Y Poon
    Imperial Cancer Research Fund, Clare Hall Laboratories, Potters Bar, Herts, UK
    EMBO J 12:3123-32. 1993
    ..We conclude that p40MO15 corresponds to CAK (cdc2/cdk2 activating kinase) and speculate that, like p33cdk2 and p34cdc2, p40MO15 requires activation by phosphorylation and association with a companion subunit...
  56. ncbi Novel CDC2-related protein kinases produced in murine hematopoietic stem cells
    M Ershler
    W A Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow
    Gene 124:305-6. 1993
    ..In total, nine different PK-encoding sequences were obtained. At least four of them encode previously unknown PKs...
  57. pmc Cyclin ET, a new splice variant of human cyclin E with a unique expression pattern during cell cycle progression and differentiation
    D Mumberg
    Institut für Molekularbiologie und Tumorforschung IMT, Philipps Universitat Marburg, Emil Mannkopff Strasse 2, D 35033 Marburg, Germany
    Nucleic Acids Res 25:2098-105. 1997
    ..These observations point to different functions for cyclin ET and E and show for the first time that the alternative splicing of cyclin E is a regulated mechanism governed by the cell cycle and differentiation...
  58. ncbi A novel cdc2-related protein kinase expressed in the nervous system
    M A Lazzaro
    Centre for Research in Neuroscience, McGill University and Montreal General Hospital Research Institute, Quebec, Canada
    J Neurochem 69:348-64. 1997
    ....
  59. pmc Transcription elongation factor P-TEFb is required for HIV-1 tat transactivation in vitro
    Y Zhu
    Department of Biochemistry, University of Iowa, Iowa City, Iowa 52242 USA
    Genes Dev 11:2622-32. 1997
    ....
  60. ncbi Construction of a high-resolution physical and transcription map of chromosome 16q24.3: a region of frequent loss of heterozygosity in sporadic breast cancer
    S A Whitmore
    Department of Cytogenetics and Molecular Genetics, Women s and Children s Hospital, North Adelaide, South Australia, 5006, Australia
    Genomics 50:1-8. 1998
    ..A total of seven known genes, including PRSM1, PISSLRE, and the recently cloned Fanconi anemia A (FAA) gene, and potential transcripts from exon-trapping experiments ..
  61. doi Inactivation of the CDKL3 gene at 5q31.1 by a balanced t(X;5) translocation associated with nonspecific mild mental retardation
    Aline Dubos
    Department of Molecular Pathology, Institut de Genetique et de Biologie Moleculaire et Cellulaire CNRS INSERM ULP, Illkirch, France
    Am J Med Genet A 146:1267-79. 2008
    ..Together the data suggest that haploinsufficiency of CDKL3 in the t(X;5) patient contributes to her phenotype, and that the CDKL3 gene is a strong candidate for nonsyndromal autosomal dominant MR...
  62. ncbi Identification of NKIAMRE, the human homologue to the mitogen-activated protein kinase-/cyclin-dependent kinase-related protein kinase NKIATRE, and its loss in leukemic blasts with chromosome arm 5q deletion
    M Midmer
    Department of Medical Biophysics, University of Toronto, and The Ontario Cancer Institute Princess Margaret Hospital, Canada
    Cancer Res 59:4069-74. 1999
    ..NKIAMRE was deleted at both alleles in 9 of 18 leukemic samples with chromosome band 5q31 abnormalities studied by fluorescence in situ chromosomal hybridization. NKIAMRE loss may be an important determinant of dysmyelopoiesis...
  63. ncbi Learning induces a CDC2-related protein kinase, KKIAMRE
    H Gomi
    Neuroscience Program, University of Southern California, Los Angeles, California 90089 2520, USA
    J Neurosci 19:9530-7. 1999
    ..These results suggest that there is a new category of cdc2-related kinases in the brain whose function may be important in learning and memory...
  64. ncbi A 38 kb segment containing the cdc2 gene from the left arm of fission yeast chromosome II: sequence analysis and characterization of the genomic DNA and cDNAs encoded on the segment
    M Machida
    Molecular Biology Department, National Institute of Bioscience and Human Technology, Higashi 1 1, Tsukuba, Ibaraki 305 8566, Japan
    Yeast 16:71-80. 2000
    ..Finally, cDNAs of all the newly identified genes were detected by RACE, proving the actual expression of these genes. The nucleotide sequence has been submitted to the EMBL database under Accession No. AB004534...
  65. ncbi Human CDK10 gene isoforms
    J C Sergere
    Service de Recherche en Hémato Immunologie, DRM DSV CEA, Centre Hayem, avenue Claude Vellefaux, Paris Cedex 10, 75475, France
    Biochem Biophys Res Commun 276:271-7. 2000
    The CDK10/PISSLRE gene has been shown to encode two different CDK-like putative kinases. The function(s) of the gene products are unknown, although a role at the G2/M transition has been suggested. We characterised two novel cDNAs...
  66. ncbi CrkRS: a novel conserved Cdc2-related protein kinase that colocalises with SC35 speckles
    T K Ko
    Wellcome CRC Institute, Cambridge, UK
    J Cell Sci 114:2591-603. 2001
    ..Anti-CrkRS immunoprecipitates phosphorylate the C-terminal domain of RNA polymerase II in vitro. Thus CrkRS may be a novel, conserved link between the transcription and splicing machinery...
  67. ncbi Interaction of p58(PITSLRE), a G2/M-specific protein kinase, with cyclin D3
    Songwen Zhang
    Gene Research Center, Fudan University Medical Center Former Shanghai Medical University, Shanghai, People s Republic of China 200032
    J Biol Chem 277:35314-22. 2002
    ..These data provide a new clue to our understanding of the cellular function of p58(PITSLRE) and cyclin D3...
  68. ncbi Gene expression profiling of melanocytic lesions
    John T Seykora
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Am J Dermatopathol 25:6-11. 2003
    ..Based on this study, DNA microarray technology appears to be a valuable tool for identifying genes that may be specifically expressed in cutaneous lesions...
  69. ncbi Gene expression networks underlying retinoic acid-induced differentiation of human retinoblastoma cells
    Aimin Li
    Mary D Allen Laboratory for Vision Research, Doheny Eye Institute, and Department of Cell and Neurobiology, The Keck School of Medicine of the University of Southern California, Los Angeles, California 90089 9112, USA
    Invest Ophthalmol Vis Sci 44:996-1007. 2003
    ..To understand the genetic regulatory pathways underlying the retinoic acid (RA) induction of cone arrestin, gene array technology and other molecular tools were used to profile global gene expression changes in human retinoblastoma cells...
  70. ncbi Gene expression profiling of human stenotic aorto-coronary bypass grafts by cDNA array analysis
    Michael Hilker
    Department of Thoracic and Cardiovascular Surgery, Johannes Gutenberg University, Mainz, Germany
    Eur J Cardiothorac Surg 23:620-5. 2003
    ..This study is aimed at identifying differentially expressed genes in human stenotic bypass grafts to detect unknown pathomechanism and to identify novel targets for prophylactic treatment options...
  71. ncbi Histone acetylation-mediated regulation of genes in leukaemic cells
    A E Chambers
    Cancer Research UK Medical Oncology Laboratory, The Medical College of St Bartholomew s Hospital, Charterhouse Square, London, EC1M 6QB, UK
    Eur J Cancer 39:1165-75. 2003
    ..The most rapidly repressed gene was MKRN3, an imprinted gene involved in the Prader-Willi syndrome...
  72. ncbi Protein expression pattern of CDK11(p58) during testicular development in the mouse
    Ziyue Niu
    State Key Laboratory of Genetic Engineering and Gene Research Center, Shanghai Medical College of Fudan University, Shanghai, People s Republic of China
    Mol Cell Biochem 270:99-106. 2005
    ..The colocalization of CDK11(p58) and cyclinD3 in the adult testis was revealed by immunofluorescence analysis...
  73. pmc Identification and characterization of the CDK12/cyclin L1 complex involved in alternative splicing regulation
    Hung Hsi Chen
    Institute of Neuroscience, National Yang Ming University, Taipei 11221, Taiwan, Republic of China
    Mol Cell Biol 26:2736-45. 2006
    ..Together, our findings indicate that CDK12 and cyclin L1/L2 are cyclin-dependent kinase and cyclin partners and regulate alternative splicing...
  74. pmc Neuronal cdc2-like kinase: a cdc2-related protein kinase with predominantly neuronal expression
    M R Hellmich
    Laboratory of Biological Chemistry, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 89:10867-71. 1992
    ....
  75. ncbi A Cdc2-related protein kinase hPFTAIRE1 from human brain interacting with 14-3-3 proteins
    Yankun Gao
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    Cell Res 16:539-47. 2006
    ....
  76. doi Unraveling the complexity of endocrine resistance in breast cancer by functional genomics
    Charles Swanton
    Cancer Research UK London Research Institute, Signal Transduction Laboratory, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Cancer Cell 13:83-5. 2008
    ..CDK10 is thus a potential biomarker for sensitivity in prospective clinical trials of patients treated with endocrine therapies...

Research Grants2

  1. Transcriptional regulation by protein kinase CDC2L5
    JASPER YIK; Fiscal Year: 2006
    ..The information gains from this study could be useful for developing new methods for AIDS therapy by specifically targeting these cellular events governed by CDC2L5. ..
  2. Mechanisms of Cone Pigment Deactivation
    Cheryl Craft; Fiscal Year: 2009
    ..Studies of the photo-transduction cascade and the molecular triggers for initiation and termination of high acuity vision are vital for sustaining lifelong vision. ..