PEAK1

Summary

Gene Symbol: PEAK1
Description: pseudopodium enriched atypical kinase 1
Alias: SGK269, pseudopodium-enriched atypical kinase 1, NKF3 kinase family member, sugen kinase 269, tyrosine-protein kinase SgK269
Species: human

Top Publications

  1. ncbi Emerging roles of pseudokinases
    Jerome Boudeau
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Trends Cell Biol 16:443-52. 2006
  2. pmc A hypusine-eIF5A-PEAK1 switch regulates the pathogenesis of pancreatic cancer
    Ken Fujimura
    Department of Pathology, University of California, San Diego, La Jolla, California Moores Cancer Center, University of California, San Diego, La Jolla, California
    Cancer Res 74:6671-81. 2014
  3. doi Analysis of a cytoskeleton-associated kinase PEAK1 and E-cadherin in gastric cancer
    Qingqu Guo
    Department of Surgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China Electronic address
    Pathol Res Pract 210:793-8. 2014
  4. pmc The pseudokinase SgK223 promotes invasion of pancreatic ductal epithelial cells through JAK1/Stat3 signaling
    Carole M Tactacan
    Cancer Research Division, The Kinghorn Cancer Centre, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney, NSW, 2010, Australia
    Mol Cancer 14:139. 2015
  5. pmc PEAK1 Acts as a Molecular Switch to Regulate Context-Dependent TGFβ Responses in Breast Cancer
    Megan Agajanian
    Department of Biology, California State University Northridge, Northridge, CA 91330, United States of America
    PLoS ONE 10:e0135748. 2015
  6. doi Identification of a PEAK1/ZEB1 signaling axis during TGFβ/fibronectin-induced EMT in breast cancer
    Megan Agajanian
    Department of Biology, California State University Northridge, Northridge, CA 91330, USA
    Biochem Biophys Res Commun 465:606-12. 2015
  7. pmc Homo- and Heterotypic Association Regulates Signaling by the SgK269/PEAK1 and SgK223 Pseudokinases
    Ling Liu
    From the Cancer Program, Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Level 1, Building 77, Monash University, Clayton, Victoria 3800
    J Biol Chem 291:21571-21583. 2016
  8. pmc KRas induces a Src/PEAK1/ErbB2 kinase amplification loop that drives metastatic growth and therapy resistance in pancreatic cancer
    Jonathan A Kelber
    Department of Pathology, Division of Surgical Oncology, UCSD, La Jolla, CA 92093, USA
    Cancer Res 72:2554-64. 2012
  9. pmc Dynamic phosphorylation of tyrosine 665 in pseudopodium-enriched atypical kinase 1 (PEAK1) is essential for the regulation of cell migration and focal adhesion turnover
    Jeanne M Bristow
    Department of Pathology and Moores Cancer Center, University of California at San Diego, La Jolla, California 92093, USA
    J Biol Chem 288:123-31. 2013
  10. doi Involvement of Lyn and the atypical kinase SgK269/PEAK1 in a basal breast cancer signaling pathway
    David R Croucher
    Cancer Research Program, The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
    Cancer Res 73:1969-80. 2013

Scientific Experts

  • G Manning
  • O Ohara
  • Jonathan A Kelber
  • Richard L Klemke
  • Megan Agajanian
  • Ling Liu
  • Roger J Daly
  • Carole M Tactacan
  • David R Croucher
  • Michael Bouvet
  • Jeanne M Bristow
  • Sharmeela Kaushal
  • Yingchun Wang
  • Emily S Humphrey
  • Yu Wei Phua
  • Darren N Saunders
  • Robert Shearer
  • Howard Chan
  • Qingqu Guo
  • Ken Fujimura
  • Luxi Zhang
  • Andrew M Lowy
  • Tracy Wright
  • Cristina Metildi
  • Yong Zheng
  • Robert M Hoffman
  • Jerome Boudeau
  • Sean Caenepeel
  • Rachel S Lee
  • Karel Novy
  • Weiwen Dai
  • Yiping Jenkins
  • Isabelle S Lucet
  • Poh Chee Ong
  • Xiuquan Ma
  • Malachia Hoover
  • Anaamika Campeau
  • Sa La Kim
  • Alexander Hou
  • Daniel Brambilla
  • Mark Cowley
  • Farhana Runa
  • Mark Pinese
  • Andrew V Biankin
  • Jan Strnadel
  • Haijun Yang
  • Zhiqiang Liu
  • Wenjie Qin
  • Shoumiao Li
  • Baozhong Li
  • Jianyun Guan
  • Nicole St-Denis
  • Anna Yue Dai
  • Ruth J Lyons
  • Brigid C Browne
  • Lorne Taylor
  • Falko Hochgräfe
  • Karen Colwill
  • Mohamed A Soliman
  • Theresa A Reno
  • Tony Pawson
  • W Rod Hardy
  • Adrian Pasculescu
  • Danny Rickwood
  • Steven L Gonias
  • Minji Jo
  • Alexander Swarbrick
  • Rick Bagshaw
  • David Gallego-Ortega
  • James W Dennis
  • Naveid Ali
  • Cunjie Zhang
  • Stephen A Tate
  • Anne Claude Gingras
  • Jessica M Weems
  • Evangeline Mose
  • Theresa Reno
  • Frederick D Park
  • Konstantin Stoletov
  • Wei Wang
  • Rui Lin
  • Thomas S Edgington
  • John R Yates
  • Hop S Tran Cao
  • Greg T Cantin
  • Diego Miranda-Saavedra
  • Dario R Alessi
  • Geoffrey J Barton
  • Tony Hunter
  • Glen Charydczak

Detail Information

Publications16

  1. ncbi Emerging roles of pseudokinases
    Jerome Boudeau
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Trends Cell Biol 16:443-52. 2006
    ..We also discuss the emerging functions of other pseudokinases, including HER3 (also called ErbB3), EphB6, CCK4 (also called PTK7), KSR, Trb3, GCN2, TRRAP, ILK and CASK...
  2. pmc A hypusine-eIF5A-PEAK1 switch regulates the pathogenesis of pancreatic cancer
    Ken Fujimura
    Department of Pathology, University of California, San Diego, La Jolla, California Moores Cancer Center, University of California, San Diego, La Jolla, California
    Cancer Res 74:6671-81. 2014
    ..Interestingly, we found that eIF5A proteins regulate PDAC cell growth by modulating the expression of PEAK1, a nonreceptor tyrosine kinase essential for PDAC cell growth and therapy resistance...
  3. doi Analysis of a cytoskeleton-associated kinase PEAK1 and E-cadherin in gastric cancer
    Qingqu Guo
    Department of Surgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China Electronic address
    Pathol Res Pract 210:793-8. 2014
    The expression of pseudopodium-enriched atypical kinase 1(PEAK1) has been studied in human cancers. However, their roles in gastric cancer are still unknown...
  4. pmc The pseudokinase SgK223 promotes invasion of pancreatic ductal epithelial cells through JAK1/Stat3 signaling
    Carole M Tactacan
    Cancer Research Division, The Kinghorn Cancer Centre, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney, NSW, 2010, Australia
    Mol Cancer 14:139. 2015
    ..SgK223, also known as Pragmin, is a pseudokinase and scaffolding protein closely related to SgK269/PEAK1...
  5. pmc PEAK1 Acts as a Molecular Switch to Regulate Context-Dependent TGFβ Responses in Breast Cancer
    Megan Agajanian
    Department of Biology, California State University Northridge, Northridge, CA 91330, United States of America
    PLoS ONE 10:e0135748. 2015
    ..We previously identified PEAK1 as a new non-receptor tyrosine kinase that associates with the cytoskeleton, and facilitates signaling of HER2/Src ..
  6. doi Identification of a PEAK1/ZEB1 signaling axis during TGFβ/fibronectin-induced EMT in breast cancer
    Megan Agajanian
    Department of Biology, California State University Northridge, Northridge, CA 91330, USA
    Biochem Biophys Res Commun 465:606-12. 2015
    ..We recently reported that PEAK1 kinase mediates signaling cross talk between TGFβ receptors and integrin/Src/MAPK pathways and functions as a ..
  7. pmc Homo- and Heterotypic Association Regulates Signaling by the SgK269/PEAK1 and SgK223 Pseudokinases
    Ling Liu
    From the Cancer Program, Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Level 1, Building 77, Monash University, Clayton, Victoria 3800
    J Biol Chem 291:21571-21583. 2016
    b>SgK269/PEAK1 is a pseudokinase and scaffolding protein that plays a critical role in regulating growth factor receptor signal output and is implicated in the progression of several cancers, including those of the breast, colon, and ..
  8. pmc KRas induces a Src/PEAK1/ErbB2 kinase amplification loop that drives metastatic growth and therapy resistance in pancreatic cancer
    Jonathan A Kelber
    Department of Pathology, Division of Surgical Oncology, UCSD, La Jolla, CA 92093, USA
    Cancer Res 72:2554-64. 2012
    ..Here, we report that the novel tyrosine kinase PEAK1 is upregulated in human malignancies, including human PDACs and pancreatic intraepithelial neoplasia (PanIN)...
  9. pmc Dynamic phosphorylation of tyrosine 665 in pseudopodium-enriched atypical kinase 1 (PEAK1) is essential for the regulation of cell migration and focal adhesion turnover
    Jeanne M Bristow
    Department of Pathology and Moores Cancer Center, University of California at San Diego, La Jolla, California 92093, USA
    J Biol Chem 288:123-31. 2013
    Pseudopodium-enriched atypical kinase 1 (PEAK1) is a recently described tyrosine kinase that associates with the actin cytoskeleton and focal adhesion (FA) in migrating cells...
  10. doi Involvement of Lyn and the atypical kinase SgK269/PEAK1 in a basal breast cancer signaling pathway
    David R Croucher
    Cancer Research Program, The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
    Cancer Res 73:1969-80. 2013
    ..In this study, we identified novel Lyn kinase substrates, the most prominent of which was the atypical kinase SgK269 (PEAK1). In breast cancer cells, SgK269 expression associated with the basal phenotype...
  11. pmc Temporal regulation of EGF signalling networks by the scaffold protein Shc1
    Yong Zheng
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto M5G 1X5, Canada
    Nature 499:166-71. 2013
    ..reorganization, trafficking and signal termination that binds Shc1 with delayed kinetics, largely through the SgK269 pseudokinase/adaptor protein...
  12. ncbi Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method
    Osamu Ohara
    Department of Human Gene Research, Kazusa DNA Research Institute, Kisarazu, Chiba, Japan
    DNA Res 9:47-57. 2002
    ..Taking all these results together, we here conclude that this new method for the construction of size-fractionated cDNA libraries makes it possible to analyze cDNAs efficiently and comprehensively...
  13. ncbi The protein kinase complement of the human genome
    G Manning
    SUGEN Inc, 230 East Grand Avenue, South San Francisco, CA 94080, USA
    Science 298:1912-34. 2002
    ..We also identified 106 protein kinase pseudogenes. Chromosomal mapping revealed several small clusters of kinase genes and revealed that 244 kinases map to disease loci or cancer amplicons...
  14. pmc The mouse kinome: discovery and comparative genomics of all mouse protein kinases
    Sean Caenepeel
    SUGEN, Incorporated, 230 East Grand Avenue, South San Francisco, CA 94025, USA
    Proc Natl Acad Sci U S A 101:11707-12. 2004
    ..Chromosomal mapping links 163 kinases to mutant phenotypes and unlocks the use of mouse genetics to determine functions of orthologous human kinases...
  15. pmc Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression [corrected]
    Yingchun Wang
    Department of Pathology, Moores Cancer Center, University of California, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 107:10920-5. 2010
    ..Here, we report the discovery of a cytoskeleton-associated kinase, pseudopodium-enriched atypical kinase 1 (PEAK1). PEAK1 is a 190-kDa nonreceptor tyrosine kinase that localizes to actin filaments and focal adhesions...
  16. pmc PEAK1, a novel kinase target in the fight against cancer
    Jonathan A Kelber
    Department of Pathology, University of California San Diego, La Jolla, CA 92093, USA
    Oncotarget 1:219-23. 2010