PDLIM3

Summary

Gene Symbol: PDLIM3
Description: PDZ and LIM domain 3
Alias: ALP, PDZ and LIM domain protein 3, alpha-actinin-2-associated LIM protein, enigma homolog
Species: human

Top Publications

  1. doi Alternative splicing of PDLIM3/ALP, for α-actinin-associated LIM protein 3, is aberrant in persons with myotonic dystrophy
    Natsumi Ohsawa
    Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Komaba, Meguro ku, Japan
    Biochem Biophys Res Commun 409:64-9. 2011
  2. ncbi Serum transferrin as a marker of bone growth in boys: correlation with serum alkaline phosphatase activity, plasma insulin-like growth factor 1 and rate of growth in height
    M Misaki
    Student Health Center, Mie University, Tsu, Japan
    Horm Metab Res 23:230-2. 1991
  3. ncbi Effect of aminohydroxypropylidene diphosphonate on the bone metabolism of patients with parathyroid adenoma
    E Ishimura
    Second Department of Internal Medicine, Osaka City University Medical School, Japan
    Horm Metab Res 25:493-7. 1993
  4. ncbi Dose-dependent renal tubular toxicity of harman and norharman in male F344 rats
    A Hagiwara
    First Department of Pathology, Nagoya City University Medical School, Japan
    Toxicol Pathol 20:197-204. 1992
  5. ncbi Raised plasma concentrations of parathyroid hormone related peptide in hypercalcemic multiple myeloma
    T Horiuchi
    Section of Endocrinology, Tokyo Metropolitan Geriatric Hospital, Japan
    Horm Metab Res 29:469-71. 1997
  6. ncbi Association between parathyroid hormone (PTH)/PTH-related peptide receptor gene polymorphism and the extent of bone mass reduction in primary hyperparathyroidism
    M Kanzawa
    Department of Medicine, Kobe University School of Medicine, Japan
    Horm Metab Res 32:355-8. 2000
  7. ncbi The usefulness of biochemical bone markers in predicting the response of hormone replacement therapy in perimenopausal cigarette smoking healthy women
    M Cubrilo-Turek
    Clinics for Internal Medicine, General Hospital Sveti Duh, Zagreb, Croatia
    Coll Antropol 23:195-201. 1999
  8. ncbi Reduced expression of platelet endothelial cell adhesion molecule-1 in bone marrow cells in mice after skeletal unloading
    Miyuki Sakuma-Zenke
    Department of Orthopaedic Surgery, University of Occupational and Environmental Health, Iseigaoka, Kitakyushu, Japan
    J Bone Miner Res 20:1002-10. 2005
  9. ncbi [A case of AIDS complicated with liver tuberculosis]
    I Kawashima
    Department of Internal Medicine, Kawasaki Municipal Hospital
    Kansenshogaku Zasshi 74:984-8. 2000
  10. ncbi Clinical significance of serum total and heat-stable alkaline phosphatase in leukemia patients
    P S Patel
    Division of Research, Gujarat Cancer Society, New Civil Hospital Compound, Ahmedabad, India
    Tumori 79:352-6. 1993

Research Grants

  1. STEVEN R MUMM; Fiscal Year: 2014
  2. Xianzhong Meng; Fiscal Year: 2015
  3. Purinergic receptors in inflammation
    Wolfgang G Junger; Fiscal Year: 2012
  4. MINERALIZATION STUDIES RELATED TO ORAL BIOLOGY
    HARRISON ANDERSON; Fiscal Year: 2005
  5. MOLECULAR BASIS OF PRONEPHRIC DUCT CELL GUIDANCE
    MALCOLM STEINBERG; Fiscal Year: 1991
  6. GROWTH FACTORS AND SKELETAL AGING
    Theresa Chen; Fiscal Year: 2000
  7. ID2 IN CELL CYCLE REGULATION AND CANCER
    Antonio Iavarone; Fiscal Year: 2010
  8. Xiaobin Wang; Fiscal Year: 2014
  9. Francesca Tentori; Fiscal Year: 2015
  10. Kelly A Birdwell; Fiscal Year: 2015

Detail Information

Publications276 found, 100 shown here

  1. doi Alternative splicing of PDLIM3/ALP, for α-actinin-associated LIM protein 3, is aberrant in persons with myotonic dystrophy
    Natsumi Ohsawa
    Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Komaba, Meguro ku, Japan
    Biochem Biophys Res Commun 409:64-9. 2011
    ..In this study, we identify two abnormal splicing events for actinin-associated LIM protein 3 (PDLIM3/ALP) and fibronectin 1 (FN1) in the skeletal muscles of DM1 patients...
  2. ncbi Serum transferrin as a marker of bone growth in boys: correlation with serum alkaline phosphatase activity, plasma insulin-like growth factor 1 and rate of growth in height
    M Misaki
    Student Health Center, Mie University, Tsu, Japan
    Horm Metab Res 23:230-2. 1991
    ..The aim of this work was to study possible relationships between serum TF, alkaline phosphatase activity (ALP), plasma insulin-like growth factor 1 (IGF-1) levels and rate of height increase in boys...
  3. ncbi Effect of aminohydroxypropylidene diphosphonate on the bone metabolism of patients with parathyroid adenoma
    E Ishimura
    Second Department of Internal Medicine, Osaka City University Medical School, Japan
    Horm Metab Res 25:493-7. 1993
    ..Serum alkaline phosphatase (ALP) and osteocalcin, markers of osteoblast activity, decreased after APD administration...
  4. ncbi Dose-dependent renal tubular toxicity of harman and norharman in male F344 rats
    A Hagiwara
    First Department of Pathology, Nagoya City University Medical School, Japan
    Toxicol Pathol 20:197-204. 1992
    ..levels were increased, and the brush border enzymes (gamma-glutamyl transpeptidase, GGT, and alkaline phosphatase, ALP) decreased...
  5. ncbi Raised plasma concentrations of parathyroid hormone related peptide in hypercalcemic multiple myeloma
    T Horiuchi
    Section of Endocrinology, Tokyo Metropolitan Geriatric Hospital, Japan
    Horm Metab Res 29:469-71. 1997
    ..We also measured serum levels of inorganic phosphorus (iP) and alkalinephosphatase activity (ALP). No significant differences in iP (3.2 +/- 0.4 vs. 4.0 +/- 2.2 mg/dl), ALP (150 +/- 28 vs...
  6. ncbi Association between parathyroid hormone (PTH)/PTH-related peptide receptor gene polymorphism and the extent of bone mass reduction in primary hyperparathyroidism
    M Kanzawa
    Department of Medicine, Kobe University School of Medicine, Japan
    Horm Metab Res 32:355-8. 2000
    ..before and one year after parathyroidectomy, as well as serum levels of calcium, phosphorus, alkaline phosphatase (ALP) and intact PTH were measured...
  7. ncbi The usefulness of biochemical bone markers in predicting the response of hormone replacement therapy in perimenopausal cigarette smoking healthy women
    M Cubrilo-Turek
    Clinics for Internal Medicine, General Hospital Sveti Duh, Zagreb, Croatia
    Coll Antropol 23:195-201. 1999
    ..in hormone replacement users (N = 35) and non-users (N = 28): serum total calcium (Ca), total alkaline phosphatase (ALP), procollagen I C-terminal propeptide (PICP), cros-linked carboxyterminal collagen I telopeptide (ICTP) and ..
  8. ncbi Reduced expression of platelet endothelial cell adhesion molecule-1 in bone marrow cells in mice after skeletal unloading
    Miyuki Sakuma-Zenke
    Department of Orthopaedic Surgery, University of Occupational and Environmental Health, Iseigaoka, Kitakyushu, Japan
    J Bone Miner Res 20:1002-10. 2005
    ..Anti-PECAM-1 antibody suppressed both ALP+ CFU-f formation and ALP production under co-culture of the osteoblastic cell line and the PECAM-1+ endothelial ..
  9. ncbi [A case of AIDS complicated with liver tuberculosis]
    I Kawashima
    Department of Internal Medicine, Kawasaki Municipal Hospital
    Kansenshogaku Zasshi 74:984-8. 2000
    ..historicica, serum levels of gamma-GTP and ALP remained high and hepatosplenomegaly gradually increased. A liver biopsy was performed...
  10. ncbi Clinical significance of serum total and heat-stable alkaline phosphatase in leukemia patients
    P S Patel
    Division of Research, Gujarat Cancer Society, New Civil Hospital Compound, Ahmedabad, India
    Tumori 79:352-6. 1993
    AIMS AND BACKGROUND: Variations in serum alkaline phosphatase (ALP) and placental-like (heat stable) alkaline phosphatase (PLAP) are found to be clinically useful in cancer patients...
  11. ncbi Alkaline phosphatase activity in gingival crevicular fluid during human orthodontic tooth movement
    Giuseppe Perinetti
    Department of Orthodontics, University G D Annunzio, Chieti, Italy
    Am J Orthod Dentofacial Orthop 122:548-56. 2002
    ..We used a longitudinal design to investigate alkaline phosphatase (ALP) activity in gingival crevicular fluid (GCF) to assess whether it can serve as a diagnostic aid in orthodontics...
  12. ncbi A prospective study of bone loss and turnover after cardiac transplantation: effect of calcium supplementation with or without calcitonin
    M J Valimaki
    Department of Medicine, University of Helsinki, Finland
    Osteoporos Int 10:128-36. 1999
    ..Markers of bone formation [serum bone-specific alkaline phosphatase (B-ALP), type I procollagen carboxyterminal propeptide (PICP) and aminoterminal propeptide (PINP)] and resorption [serum ..
  13. ncbi Biochemical parameters as prognostic factors in prostatic adenocarcinoma
    S Vesalainen
    Department of Surgery, University of Kuopio, Finland
    Acta Oncol 34:53-9. 1995
    The serum levels of creatinine (CR), alkaline phosphatase (ALP), acid phosphatase (ACP) and tartrate inhibitable acid phosphatase (TIAP) were related to Gleason score, TM-category, disease progression and survival in 325 prostatic ..
  14. doi Sclerostin and the regulation of bone formation: Effects in hip osteoarthritis and femoral neck fracture
    Jon Power
    Bone Research Division, Department of Medicine, University of Cambridge, Cambridge, UK
    J Bone Miner Res 25:1867-76. 2010
    ..5 mm in diameter) with at least one canal staining for alkaline phosphatase (ALP), a marker of bone formation...
  15. doi Hyperglycemia in acute aluminum phosphide poisoning as a potential prognostic factor
    O Mehrpour
    Department of Forensic Medicine, Faculty of Medicine, Medical Sciences University of Tehran, Tehran, Iran
    Hum Exp Toxicol 27:591-5. 2008
    Aluminum phosphide (AlP) is a solid fumigant widely used in Iran as a grain preservative...
  16. ncbi [Effect of preoperative biliary drainage on liver function changes in patients with malignant obstructive jaundice in the low bile duct before and after pancreaticoduodenectomy]
    Dong Chen
    Department of Hepatobiliary Surgery, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong, PR China
    Ai Zheng 27:78-82. 2008
    ..This study was to investigate the perioperative liver function changes and prognosis of the patients...
  17. ncbi Effects of retinoic acid on N-glycosylation and mRNA stability of the liver/bone/kidney alkaline phosphatase in neuronal cells
    W H Mueller
    Zentrum Biochemie, Medizinische Hochschule Hannover, Hannover, Germany
    J Cell Physiol 182:50-61. 2000
    Alkaline phosphatase (ALP) is a glycoenzyme that is highly expressed during carcinogenesis and is induced by retinoic acid (RA) in various cells...
  18. pmc Role of alkaline phosphatase from Manduca sexta in the mechanism of action of Bacillus thuringiensis Cry1Ab toxin
    Ivan Arenas
    Departamento de Microbiologia Molecular, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Cuernavaca, Morelos 62250, Mexico
    J Biol Chem 285:12497-503. 2010
    ..Two Manduca sexta glycosylphosphatidylinositol-anchored proteins, aminopeptidase (APN) and alkaline phosphatase (ALP), have been shown to bind Cry1Ab, although their role in toxicity remains to be determined...
  19. ncbi Nuclear plasticity and timing mechanisms of the initiation of alkaline phosphatase expression in cytoplasm-transferred blastomeres of ascidians
    K Kobayashi
    Department of Biological Sciences, Tokyo Institute of Technology, Nagatsuta, Midori ku, Yokohama, 226 8501, Japan
    Dev Biol 234:510-20. 2001
    ..We investigated three aspects of the expression of endoderm-specific alkaline phosphatase (ALP) activity...
  20. ncbi Mapping quantitative trait loci that influence blood levels of alkaline phosphatase in MRL/MpJ and SJL/J mice
    A K Srivastava
    Musculoskeletal Disease Center, JLP VA Medical Center, Loma Linda, CA, 92357, USA
    Bone 35:1086-94. 2004
    To examine the hypothesis that serum alkaline phosphatase (ALP) levels have a heritable component, we analyzed blood from two inbred strains of mice, MRL/MpJ and SJL, which exhibit 90% difference in total serum ALP activity (268+/-26 vs...
  21. ncbi Effect of glucocorticoid treatment on biochemical and hormonal blood parameters in early pregnant gilts
    A Madej
    Department of Animal Physiology, Swedish University of Agricultural Sciences, Uppsala, Sweden
    Acta Vet Scand 38:263-73. 1997
    ..for analysis of aspartate aminotransferase (S-ASAT), alanine aminotransferase (S-ALAT), alkaline phosphatase (S-ALP), S-cholesterol, S-triglycerides, S-fructosamine, S-urea, S-total protein, and for electrophoretic fractionation of ..
  22. ncbi Longitudinal monitoring of subgingival colonization by Actinobacillus actinomycetemcomitans, and crevicular alkaline phosphatase and aspartate aminotransferase activities around orthodontically treated teeth
    Giuseppe Perinetti
    Unit of Orthodontics, Department of Oral Sciences, School of Dentistry, University G D Annunzio, Chieti, Italy
    J Clin Periodontol 31:60-7. 2004
    ..design to examine subgingival colonization of Actinobacillus actinomycetemcomitans (Aa) and alkaline phosphatase (ALP) and aspartate aminotransferase (AST) activities in gingival crevicular fluid (GCF) in order to assess whether ..
  23. ncbi Temporal pattern of stimulation of osteoblast-associated genes during mechanically-induced osteogenesis in vivo: early responses of osteocalcin and type I collagen
    D Pavlin
    Department of Orthodontics, The University of Texas Health Science Center at San Antonio, 78284 7910, USA
    Connect Tissue Res 42:135-48. 2001
    ..Temporal pattern of regulation of osteocalcin (OC), alkaline phosphatase (ALP), and type I collagen (collagen I) was determined during mechanically-induced osteoblast differentiation in vivo, ..
  24. ncbi Risk factors affecting metaphyseal irregularities in the radius and ulna of growing Newfoundland dogs
    C Trangerud
    Department of Companion Animal Clinical Sciences, Norwegian School of Veterinary Science, PO Box 8146 Dep, N 0033 Oslo, Norway
    J Anim Sci 85:2437-44. 2007
    ..effects of litters, BW, circumferences of the distal radius and ulna (CDRU), and total serum alkaline phosphatase (ALP) concentrations. The study included 118 Newfoundland dogs (60 females, 58 males), derived from 32 litters...
  25. ncbi Comparison of two newly identified tumor markers (CAR-3 and DU-PAN-2) with CA 19-9 in patients with pancreatic cancer
    C Ferrara
    Istituto di Medicina Interna,
    Tumori 77:56-60. 1991
    ..Correlations were found between the behavior of all three markers and that of the cholestasis indices (ALP and GGT)...
  26. ncbi Osteoporotic cytokines and bone metabolism on rats with induced hyperthyroidism; changes as a result of reversal to euthyroidism
    Gonul Simsek
    Istanbul University, Turkey
    Chin J Physiol 46:181-6. 2003
    ..and serum IL-1beta, IL-6, TNFalpha, Calcium (Ca), phosphorous (P), parathyroid hormone (PTH), alkaline phosphatase (ALP), bone alkaline phosphatase (B-ALP) levels were measured and differential leucocyte counts were made initially, at ..
  27. ncbi Monoclonal antibodies against tissue-nonspecific alkaline phosphatase. Report of the ISOBM TD9 workshop
    P Magnusson
    Bone and Mineral Metabolic Unit, Division of Clinical Chemistry, Department of Biomedicine and Surgery, Linkoping University Hospital, Linkoping, Sweden
    Tumour Biol 23:228-48. 2002
    ..The evaluation included the following antigen forms: (a) commercially available preparations of human bone ALP (BALP) and liver ALP (LALP); (b) human BALP isoforms, B/I, B1 and B2; and (c) soluble secreted epitope-tagged ..
  28. pmc Hepatic osteodystrophy and liver cirrhosis
    Vedat Goral
    Department of Gastroenterology, Dicle University School of Medicine, 21280 Diyarbakir, Turkey
    World J Gastroenterol 16:1639-43. 2010
    ..To investigate the correlation between hepatic osteodystrophy and osteoporosis in patients with liver cirrhosis...
  29. ncbi Changes in the structure and function of the kidney of rats chronically exposed to cadmium. I. Biochemical and histopathological studies
    Małgorzata M Brzóska
    Department of Toxicology, Medical University of Białystok, Mickiewicza 2c str, 15 222, Białystok, Poland
    Arch Toxicol 77:344-52. 2003
    ..as urinary total N-acetyl-beta- d-glucosaminidase (NAG-T) and its isoenzyme B (NAG-B), and alkaline phosphatase (ALP) were used...
  30. ncbi Genotype-by-sex and environment-by-sex interactions influence variation in serum levels of bone-specific alkaline phosphatase in adult baboons (Papio hamadryas)
    L M Havill
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Bone 35:198-203. 2004
    ..we conducted a statistical genetic analysis of serum concentrations of bone-specific alkaline phosphatase (Bone ALP), a highly specific marker of osteoblast function that is elevated in persons with conditions like osteoporosis ..
  31. ncbi Role of ascorbic acid in periodontal ligament cell differentiation
    Satoshi Ishikawa
    Section of Periodontology, Dept of Hard Tissue Engineering, Graduate School, Center of Excellence Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo Medical and Dental University, Japan
    J Periodontol 75:709-16. 2004
    ..The purpose of this study was to determine the role of ascorbic acid on the early osteoblastic differentiation of PDL cells, with regard to alkaline phosphatase (ALP) activity, type I collagen production and integrin expression.
  32. doi Risk factors for abnormal liver function tests in patients with ileal pouch-anal anastomosis for underlying inflammatory bowel disease
    Udayakumar Navaneethan
    The Pouchitis Clinic, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Gastroenterol 104:2467-75. 2009
    ..The aim of this study was to evaluate the prevalence and to identify risk factors for abnormal LFTs in patients with IPAA and underlying IBD...
  33. pmc Circulating insulin-like growth factor binding protein-4 (IGFBP-4) is not regulated by parathyroid hormone and vitamin D in vivo: evidence from children with rickets
    Abdullah Bereket
    Marmara University Medical Faculty, Department of Pediatric Endocrinology, Istanbul, Turkey
    J Clin Res Pediatr Endocrinol 2:17-20. 2010
    ..25-hydroxy(OH)vitamin D, IGF-I, IGF-II and transforming growth factor (TGF)-b are the major regulators of IGFBP-4 production in vitro. However, little is known about the in vivo regulation of circulating IGFBP-4 in humans...
  34. ncbi Adult hypophosphatasia treated with teriparatide
    Michael P Whyte
    Center for Metabolic Bone Disease and Molecular Research, Shriners Hospitals for Children, and Division of Bone and Mineral Diseases, Washington University School of Medicine at Barnes Jewish Hospital, St Louis, MI 63131 3597, USA
    J Clin Endocrinol Metab 92:1203-8. 2007
    Hypophosphatasia (HPP) features low serum alkaline phosphatase (ALP) activity (hypophosphatasemia) due to loss-of-function mutation within TNSALP, the gene that encodes "tissue-nonspecific" ALP (TNSALP)...
  35. ncbi Alterations of blood analyses at relapse of osteosarcoma and Ewing's sarcoma
    E Hannisdal
    Department of Oncology, Norwegian Radium Hospital, Oslo
    Acta Oncol 29:585-7. 1990
    ..and thrombocyte counts, gamma glutamyltransferase (GT), lactate dehydrogenase (LD) and alkaline phosphatase (ALP). Sixteen relapsing patients diagnosed from 1970 to 1987 were eligible in each sarcoma group...
  36. ncbi [Comparison of whole bone marrow culture method and density gradient centrifugation method of isolating hBMSCs]
    Qian Huang
    Lnstitute of Plastic and Aesthetic Surgery, Guangdong Medical College, Zhanjiang Guangdong 524023, PR China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 23:1360-4. 2009
    ..To make a comparative study on the effects of whole bone marrow culture method and density gradient centrifugation method in isolating hBMSCs...
  37. ncbi The effect of olpadronate in ovariectomized thyroxine-treated rats
    S Zeni
    Seccion Osteopatias Medicas, Hospital de Clinicas, Jose de San Martin, Facultad de Medicina, Universidad de Buenos Aires, Argentina
    Bone 21:329-33. 1997
    ..of the study, blood samples were analyzed for serum calcium, phosphorus, T4, total and bone alkaline phosphatase (ALP and b-ALP), and urinary samples for hydroxyproline/creatinine ratio (HOProl/creat)...
  38. ncbi The effect of different buffers and amounts of intestinal alkaline phosphatase isoforms on total alkaline phosphatase activity
    Makoto Matsushita
    Department of Clinical Chemistry, Saitama Prefectural University Junior College, 820 Sannomiya, Koshigaya 343 8540, Japan
    Clin Chim Acta 319:49-55. 2002
    ..DEA and 2-ethylaminoethanol, EAE) have been widely used for the measurement of serum total alkaline phosphatase activity (ALP) in clinical laboratories, and the individual isozyme are activated differently by respective buffers.
  39. ncbi Molecular characterization of a PDZ-LIM protein in Atlantic salmon (Salmo salar): a fish ortholog of the alpha-actinin-associated LIM-protein (ALP)
    Øivind Andersen
    Institute of Aquaculture Research, P O Box 5010, N 1432 Aas, Norway
    J Muscle Res Cell Motil 25:61-8. 2004
    ..A full-length cDNA encoding the ortholog of the alpha-actinin-associated LIM protein (ALP) was isolated from white skeletal muscle of Atlantic salmon (Salmo salar)...
  40. ncbi [Interventional effect of platelet lysate on osteogenic differentiation of BMSCs in rats]
    Huiping Song
    Shanxi Provincial Tissue Bank, Taiyuan Shanxi, 030006, P R China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 22:737-41. 2008
    ..To explore the interventional effect of platelet lysate (PL) on osteogenic differentiation of BMSCs by induction in rats in vitro...
  41. doi Early predisposition to osteomalacia in Indian adults on phenytoin or valproate monotherapy and effective prophylaxis by simultaneous supplementation with calcium and 25-hydroxy vitamin D at recommended daily allowance dosage: a prospective study
    Geetha Krishnamoorthy
    Department of Biochemistry, Lokmanya Tilak Municipal Medical College and Hospital, Sion, Mumbai 400 022, India
    Neurol India 58:213-9. 2010
    Long-term therapy with antiepileptic drugs (AED) may be associated with increased total serum alkaline phosphatase (ALP) levels and reduced serum calcium, inorganic phosphorous, and vitamin D levels...
  42. ncbi Isoenzyme studies on Toxoplasma gondii isolates using isoelectric focusing
    G Barnert
    ,
    Zentralbl Bakteriol Mikrobiol Hyg A 268:476-81. 1988
    ..of the following 14 enzymes in the cell lysates was investigated: IDH, MDH, ME, 6PG, G6P, LDH, IPO, HEX, PGM, EST, ALP, ACP, LAP, and PGI...
  43. ncbi Expression of the germ cell alkaline phosphatase gene in human choriocarcinoma cells
    S Watanabe
    Human Genetics Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20892
    J Biol Chem 264:12611-9. 1989
    Alkaline phosphatase (ALP) in human choriocarcinoma cells (malignant trophoblasts) was characterized by its greater sensitivity to EDTA and L-leucine inhibition as compared with the placental isozyme...
  44. ncbi Immunochemical characterization of alkaline phosphatase from the fluid of sterile and fertile Echinococcus granulosus cysts
    Ali Vatankhah
    Parasitology Department, Pasteur Institute of Iran, Pasteur Square, 13164, Tehran, Iran
    Parasitol Res 90:372-6. 2003
    Alkaline phosphatase (ALP) from hydatid cyst fluid (HCF) was purified and characterized for comparison between fertile and sterile HCF. Samples were obtained from slaughtered sheep and then sterile and fertile cysts were separated...
  45. ncbi Comparative inhibition of human alkaline phosphatase and diamine oxidase by bromo-levamisole, cimetidine and various derivatives
    T Metaye
    Department of Biochemistry, U E R of Medecine Pharmacy, Poitiers, France
    Biochem Pharmacol 37:4263-8. 1988
    ..are examined in vitro in order to investigate their comparative inhibition, towards alkaline phosphatase (ALP) from human liver and diamine-oxidase (DAO) from human placenta...
  46. ncbi Bone marrow adipocytes: a neglected target tissue for growth hormone
    Evelien F Gevers
    Division of Molecular Neuroendocrinology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    Endocrinology 143:4065-73. 2002
    ..005) lower in dw/dw rats, though alkaline phosphatase (ALP) activity in individual osteoblasts was unchanged...
  47. ncbi Porous tantalum trabecular metal scaffolds in combination with a novel marrow processing technique to replace autograft
    Xuenong Zou
    Orthopaedic Research Laboratory, Aarhus University Hospital, 8000 Aarhus C, Denmark
    Adv Exp Med Biol 585:197-208. 2006
    ....
  48. ncbi Automated and semiautomated analysis of rat alkaline phosphatase isoenzymes
    W E Hoffmann
    University of Illinois College of Veterinary Medicine, College of Veterinary Medicine, Urbana 61801, USA
    Toxicol Pathol 22:633-8. 1994
    A semiautomated quantitative assay for rat serum alkaline phosphatase (ALP) isoenzyme determination was developed, incorporating selective precipitation of bone alkaline phosphatase (BALP) with wheat germ lectin and differential ..
  49. ncbi Prenatal exposure to diazepam and alprazolam, but not to zolpidem, affects behavioural stress reactivity in handling-naïve and handling-habituated adult male rat progeny
    Carla Cannizzaro
    Department of Pharmacological Sciences, Palermo University, V Vespro 129, 90127 Palermo, Italy
    Brain Res 953:170-80. 2002
    ..study investigated the consequences of a late prenatal treatment with three GABA/BDZ R agonists (DZ) alprazolam (ALP) and zolpidem (ZOLP)), on different stress-related behavioural patterns, in non-handled (NH), short-lasting handled ..
  50. ncbi Influence of lighting conditions on daily rhythm of bone metabolism in rats and possible involvement of melatonin and other hormones in this process
    Z Ostrowska
    Department of Clinical Biochemistry, The Medical University of Silesia, Zabrze, Poland
    Endocr Regul 37:163-74. 2003
    ..of biochemical markers of bone and mineral metabolism such as the activity of serum alkaline phosphatase (ALP), the concentration of carboxyterminal propeptide of type I procollagen (PICP), cross-linked carboxyterminal ..
  51. ncbi [Experimental study of the effect of new bone formation on new type artificial bone composed of bioactive ceramics]
    Minghua Zhu
    Sichuan Diseases Control and Prevention, Chengdu Sichuan 610041, PR China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 19:174-7. 2005
    ..To investigate the osteogenic potential of four kinds of new bioactive ceramics combined with bovine bone morphogenetic proteins (BMP) and to explore the feasibility of using compounds as bone substitute material...
  52. ncbi Preoperative localization of parathyroid adenomas with technetium-99m methoxyisobutylisonitrile imaging: relationship with P-glycoprotein expression, oxyphilic cell content, and tumoral tissue volume
    Bulent Turgut
    Department of Nuclear Medicine, Cumhuriyet University School of Medicine, Sivas, Turkey
    Cancer Biother Radiopharm 21:579-90. 2006
    ....
  53. ncbi Novel mouse model of autosomal semidominant adult hypophosphatasia has a splice site mutation in the tissue nonspecific alkaline phosphatase gene Akp2
    Tertius A Hough
    Mammalian Genetics Unit, Mary Lyon Centre, Medical Research Council, Harwell, Oxfordshire, United Kingdom
    J Bone Miner Res 22:1397-407. 2007
    ..Here we report on mice with an induced mutation in Akp2 that affects splicing. The phenotype of homozygotes mirror aspects of the adult form of HPP...
  54. ncbi Novel loci regulating bone anabolic response to loading: expression QTL analysis in C57BL/6JXC3H/HeJ mice cross
    Chandrasekhar Kesavan
    Musculoskeletal Disease Center, Jerry L Pettis VA Medical Center, 11201 Benton Street, Loma Linda, CA 92357, USA
    Bone 41:223-30. 2007
    ..We then measured the expression changes of bone marker genes, bone sialoprotein (BSP), alkaline phosphatase (ALP) and housekeeping genes, beta-actin and peptidylprolyl isomerase A (PPIA), by using real-time PCR in both the ..
  55. ncbi Gingival crevicular fluid alkaline phosphatase activity reflects periodontal healing/recurrent inflammation phases in chronic periodontitis patients
    Giuseppe Perinetti
    Department of Oral Sciences, University G D Annunzio, Chieti, Italy
    J Periodontol 79:1200-7. 2008
    ..One of these host enzymes is alkaline phosphatase (ALP), the GCF activity of which has been associated with periodontal inflammation...
  56. ncbi [Effect of various concentrations of platelet-rich plasma on osteogenic differentiation of skeletal muscle-derived stem cells]
    Liancheng Shan
    Department of Orthopaedics, Shanghai Sixth People s Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, PR China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 23:991-6. 2009
    ..To investigate the effect of various concentration of platelet-rich plasma (PRP) on osteogenic differentiation of rabbit skeletal muscle-derived stem cells (SMSCs) cultured in vitro...
  57. ncbi Effects of cortical bone perforation on experimental guided bone regeneration
    Ichiro Nishimura
    Division of Oral Pathology, Graduate School of Dentistry, Tohuku University, Sendai, Japan
    Clin Oral Implants Res 15:293-300. 2004
    ..Alkaline phosphatase (ALP) was expressed on the bone surrounding the perforation...
  58. ncbi Functional analysis of the single nucleotide polymorphism (787T>C) in the tissue-nonspecific alkaline phosphatase gene associated with BMD
    Masae Goseki-Sone
    Department of Food and Nutrition, Japan Women s University, Tokyo, Japan
    J Bone Miner Res 20:773-82. 2005
    ..Furthermore, the effects of amino acid substitution on the catalytic property of the protein translated from the 787T>C gene were examined...
  59. doi Effect of smoking and CYP2D6 polymorphisms on the extent of fluvoxamine-alprazolam interaction in patients with psychosomatic disease
    Hideyo Sugahara
    Department of Psychosomatic Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Eur J Clin Pharmacol 65:699-704. 2009
    ..The aim of this study was to investigate the factors responsible for interindividual variability in the extent of interaction between FVX and alprazolam (ALP).
  60. doi Up-regulation of alkaline phosphatase expression in human primary osteoblasts by cocultivation with primary endothelial cells is mediated by p38 mitogen-activated protein kinase-dependent mRNA stabilization
    Sven Hager
    Department of Plastic and Hand Surgery, University of Freiburg Medical Center, Freiburg, Germany
    Tissue Eng Part A 15:3437-47. 2009
    ..ECs and human primary osteoblasts (hOBs) leads to a cell contact-dependent up-regulation of alkaline phosphatase (ALP) expression in osteoblasts, indicating that cocultivated ECs may support osteogenic differentiation and ..
  61. ncbi Amino acid phosphatase activity of alkaline phosphatase. A possible role of protein phosphatase
    T Shinozaki
    Department of Orthopedic Surgery, Gunma University School of Medicine, Maebashi, Japan
    Eur J Biochem 227:367-71. 1995
    Alkaline phosphatase (ALP) hydrolyzed phosvitin and amino acid phosphates demonstrating nonisotropy at different pH...
  62. ncbi Calciuria in children with juvenile chronic arthritis
    D Nemcova
    Department of Pediatrics, First Medical Faculty, Charles University, Prague, Czech Republic
    Acta Univ Carol Med (Praha) 40:43-5. 1994
    ..12 patients with confirmed diagnosis of JCA basic biochemical indices of bone metabolism, were performed (S-Ca, P, ALP, U-Ca/U-creatinine, U-P)...
  63. ncbi Characterization of titanium surfaces with calcium and phosphate and osteoblast adhesion
    B Feng
    School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, PR China
    Biomaterials 25:3421-8. 2004
    ..The cell count and alkaline phosphatase (ALP) specific activity assay were used for biochemical analyses...
  64. doi Biochemical response to ursodeoxycholic acid and long-term prognosis in primary biliary cirrhosis
    Christophe Corpechot
    Hepatology Department, Reference Center for Inflammatory Biliary Diseases, Saint Antoine Hospital, National Institute of Health and Medical Research INSERM, Pierre et Marie Curie University Paris 6, France
    Hepatology 48:871-7. 2008
    ..It has been recently proposed that an alkaline phosphatase (ALP) decline of more than 40% in baseline value or a normal level after 1 year of UDCA treatment (Barcelona criteria) ..
  65. doi Changes in alkaline phosphatase levels in patients with prostate cancer receiving degarelix or leuprolide: results from a 12-month, comparative, phase III study
    Fritz H Schroder
    Department of Urology, Erasmus University Medical Center, Rotterdam, The Netherlands
    BJU Int 106:182-7. 2010
    ..5 mg in the control of total serum alkaline phosphatase (S-ALP) levels in patients with prostate cancer...
  66. ncbi Bone and mineral metabolism in transient hyperphosphatasaemia
    S Kutilek
    Department of Pediatrics, 1st Medical Faculty, Charles University, Prague, Czech Republic
    Acta Univ Carol Med (Praha) 40:47-51. 1994
    Transient hyperphosphatasaemia (TH) is a benign disorder characterized by transient elevation of S-ALP activity not exceeding duration of 4 months in children under 5 years of age, with elevated activity of bone isoenzymes of ALP with no ..
  67. ncbi Alkaline phosphatase in rheumatoid arthritis patients: possible contribution of bone-type ALP to the raised activities of ALP in rheumatoid arthritis patients
    Yuki Nanke
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo 162 0054, Japan
    Clin Rheumatol 21:198-202. 2002
    Raised serum alkaline phosphatase (ALP) activity in rheumatoid arthritis (RA) has been reported, although its aetiology is not clear. In this paper we investigate whether synovial tissue is a possible source of raised ALP activity in RA...
  68. ncbi Characterization of mineral deposits formed in cultures of a hamster tartrate-resistant acid phosphatase (TRAP) and alkaline phosphatase (ALP) double-positive cell line (CCP)
    Hisako Sakiyama
    Division of Oncology and Biology, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage ku Chiba 263 8555, Japan
    Cell Tissue Res 309:269-79. 2002
    We have established tartrate-resistant acid phosphatase (TRAP) and alkaline phosphatase (ALP) double-positive cell lines (CCP-2, CCP-7, CCP-8) from hamster bone marrow...
  69. ncbi Synergistic effect of fibroblast growth factor-4 in ectopic bone formation induced by bone morphogenetic protein-2
    K Kubota
    Department of Periodontology, Hard Tissue Engineering, Tokyo Dental and Medical University, Japan
    Bone 31:465-71. 2002
    ..FGFR-1 and FGFR-2) were expressed in mesenchymal cells and chondrocytes, and in the area of alkaline phosphatase (ALP) expression...
  70. ncbi Membrane targeted anticancer drugs: potent inducers of apoptosis and putative radiosensitisers
    V Jendrossek
    Department of Radiation Oncology, University of Tuebingen, Hoppe Seyler Str 3, D 72076 Tuebingen, Germany
    Curr Med Chem Anticancer Agents 3:343-53. 2003
    ..Two classes of synthetic phospholipid analogues: the alkyllysophospholipids (ALP) with the prototypical 1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (Et-18-OCH3, Edelfosine), as well as ..
  71. ncbi Effects of therapeutic and toxic doses of levamisole on thyroid hormones and some biochemical parameters in sheep
    Ahmet Atessahin
    Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Firat University, 23119 Elazig, Turkey
    Cell Biochem Funct 22:281-6. 2004
    ..On the other hand, free T3 and free T4 levels were not changed in either group. While serum alkaline phosphatase (ALP) activities were decreased, aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase ..
  72. ncbi Developmental changes in morphometry of the small intestine and jejunal sucrase activity during the first nine weeks of postnatal growth in pigs
    O Adeola
    Department of Animal Sciences, Purdue University, West Lafayette, IN 47907 2054, USA
    J Anim Sci 84:112-8. 2006
    ..Sucrase and alkaline phosphatase (ALP) activities of the jejunal brush-border membrane, prepared by differential centrifugation and Mg2+ precipitation, ..
  73. pmc Aluminium phosphide poisoning
    R G Bogle
    Department of Cardiology, Ealing Hospital NHS Trust, Middlesex UB1 3HW, United Kingdom
    Emerg Med J 23:e3. 2006
    We describe a lethal poisoning in a healthy woman caused by deliberate ingestion of aluminium phosphide (AlP), a pesticide used to kill rodents and insects...
  74. ncbi Low serum alkaline phosphatase activity and pathologic fracture: case report and brief review of hypophosphatasia diagnosed in adulthood
    Hasnain M Khandwala
    Division of Endocrinology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Endocr Pract 12:676-81. 2006
    To describe an elderly patient with low serum alkaline phosphatase (ALP) activity detected after a pathologic fracture and to characterize hypophosphatasia in adult patients.
  75. ncbi Evaluation of subchronic chlorpyrifos poisoning on hematological and serum biochemical changes in mice and protective effect of vitamin C
    Suleiman Ambali
    Department of Veterinary Physiology and Pharmacology Ahmadu Bello University, Zaria, Kaduna State, Nigeria
    J Toxicol Sci 32:111-20. 2007
    ..Cl-), urea, creatinine, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP)...
  76. doi Simvastatin antagonizes tumor necrosis factor-alpha inhibition of bone morphogenetic proteins-2-induced osteoblast differentiation by regulating Smad signaling and Ras/Rho-mitogen-activated protein kinase pathway
    Misuzu Yamashita
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama City 700 8558, Japan
    J Endocrinol 196:601-13. 2008
    ..cells suppressed the BMP-2-induced expression of key osteoblastic markers including Runx2 and alkaline phosphatase (ALP) activity...
  77. doi Heparin inhibits BMP-2 osteogenic bioactivity by binding to both BMP-2 and BMP receptor
    Shin Kanzaki
    Division of Oral and Maxillofacial Reconstructive Surgery, Department of Oral and Maxillofacial Surgery, Kyushu Dental College, Kitakyushu, Japan
    J Cell Physiol 216:844-50. 2008
    ..Our results showed that heparin inhibited alkaline phosphatase (ALP) activity and mineralization in osteoblastic cells cultured with BMP-2...
  78. doi Evaluation of some pharmacological activities of ethanol extracts of seeds, pericarp and leaves of Eugenia Jamolana in rats
    S M A El-Shenawy
    Dep of Pharmacology, National Research Centre, Tahrir St, Dokki, Egypt
    Inflammopharmacology 17:85-92. 2009
    ..All tested extracts showed significant reduction in elevated serum ALT, AST and ALP levels as compared with CCl4 treated group. The ethanol extract of E...
  79. doi Prognostic grouping of metastatic prostate cancer using conventional pretreatment prognostic factors
    Arto Mikkola
    Department of Urology, Helsinki University Central Hospital, Helsinki, Finland
    Scand J Urol Nephrol 43:265-70. 2009
    ..variables age, haemoglobin concentration (Hb), erythrocyte sedimentation rate (ESR), alkaline phosphatase (ALP), prostate-specific antigen (PSA), plasma testosterone and estradiol level in hormonally treated patients with ..
  80. pmc Glycosylation differences contribute to distinct catalytic properties among bone alkaline phosphatase isoforms
    Cecilia Halling Linder
    Division of Clinical Chemistry, Laboratory Medicine Center, Linkoping University Hospital, Linkoping, Sweden
    Bone 45:987-93. 2009
    ..physiological substrates and to compare those properties with two recombinant isoforms of the tissue-nonspecific ALP (TNALP) isozyme, i.e...
  81. doi Toxicological evaluation of Tetracarpidium conophorum nut oil-based diet in rats
    A T Oladiji
    Department of Biochemistry, University of Ilorin, PMB 1515 Ilorin, Nigeria
    Food Chem Toxicol 48:898-902. 2010
    ..05) different from those fed on soybean oil-based diet. The reduction in the activities of ALP, GOT and GPT in the liver and heart of animals fed on the nut oil-based diet was accompanied by increase in the ..
  82. ncbi Chemiluminescent detect of E. coli O157:H7 using immunological method based on magnetic nanoparticles
    Zhiyang Li
    State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, China
    J Nanosci Nanotechnol 10:696-701. 2010
    ..coli O157:H7 monoclonal antibody. Commercial alkaline phosphatase conjugated horse anti-mouse immunoglobulin (ALP-Ab) was used to bind with the monoclonal antibody, finally the chemiluminescent signals were detected by adding 3-(..
  83. ncbi Hepatoprotective effects of ethanolic extract of Cnidoscolus aconitifolius on paracetamol-induced hepatic damage in rats
    A A Oyagbemi
    Department of Veterinary Physiology, Biochemistry and Pharmacology, University of Ibadan, Ibadan, Oyo State, Nigeria
    Pak J Biol Sci 13:164-9. 2010
    ..05) increase in the plasma Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Alkaline phosphatase (ALP), Blood Urea Nitrogen (BUN), triglycerides (TAG) with total cholesterol (TC) and Low Density Lipoprotein (LDL-..
  84. doi A comparison of bioreactors for culture of fetal mesenchymal stem cells for bone tissue engineering
    Zhi Yong Zhang
    Department of Mechanical Engineering, Faculty of Engineering, National University of Singapore, Centre for Biomedical Materials Applications and Technology, Singapore
    Biomaterials 31:8684-95. 2010
    ..bioreactor-treated scaffolds experienced earlier and more robust osteogenic differentiation on von Kossa staining, ALP induction (1.2-1.6×, p < 0.01) and calcium deposition (1.3-2.3×, p < 0.01)...
  85. doi Emodin-8-O-β-D-glucoside from Polygonum amplexicaule D. Don var. sinense Forb. promotes proliferation and differentiation of osteoblastic MC3T3-E1 cells
    Mei Xian Xiang
    College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
    Molecules 16:728-37. 2011
    ..34% to 32.16%. Moreover, EG increased alkaline phosphatase (ALP) expression in MC3T3-E1 cells at the concentration from 0...
  86. doi Mineral trioxide aggregate promotes odontoblastic differentiation via mitogen-activated protein kinase pathway in human dental pulp stem cells
    Xiu Zhao
    Department of Operative Dentistry and Endodontics, School of Stomatology, Fourth Military Medical University, and Department of Hepatobiliary Surgery, Xijing Hospital, Xi an, 710032, People s Republic of China
    Mol Biol Rep 39:215-20. 2012
    ..MTA significantly increased the expression of alkaline phosphatase (ALP), dentin sialophosphoprotein (DSPP), type I collagen (COLI), osteocalcin (OCN) and bone sialoprotein (BSP) mRNAs ..
  87. doi Influence of platelet-rich plasma on ectopic bone formation of bone marrow stromal cells in porous coral
    S Zhang
    Department of Oral and Maxillofacial Surgery, School of Stomatology, Fourth Military Medical University, Xi an, PR China
    Int J Oral Maxillofac Surg 40:961-5. 2011
    ..Coral scaffolds loading MSCs or PRP alone acted as control. Alkaline phosphatase (ALP) activity of the specimens cultured in vitro for 7 and 14 days was measured, and the level of ectopic bone ..
  88. doi The effects of low-level laser irradiation on differentiation and proliferation of human bone marrow mesenchymal stem cells into neurons and osteoblasts--an in vitro study
    Masoud Soleimani
    Department of Hematology, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran
    Lasers Med Sci 27:423-30. 2012
    ..was tested on the second, fifth, seventh, and tenth day of differentiation via analysis of alkaline phosphatase (ALP) activity...
  89. pmc Manipulation of miRNA activity accelerates osteogenic differentiation of hMSCs in engineered 3D scaffolds
    Peter D Mariner
    Howard Hughes Medical Institute, University of Colorado at Boulder, CO, USA
    J Tissue Eng Regen Med 6:314-24. 2012
    ..miRNA mimics and inhibitors that had originally identified for their ability to increase Alkaline Phosphatase (ALP) activity...
  90. pmc Effects of an antibacterial membrane on osteoblast-like cells in vitro
    Jun Ye
    State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, People s Republic of China
    Int J Nanomedicine 6:1853-61. 2011
    ..bromide (MTT) assay, cell viability with a cell viability analyzer, and alkaline phosphatase (ALP) activity and Ca(2+) concentration of osteoblast-like cell matrix by enzyme-linked immunosorbent assay...
  91. doi Combined mesenchymal stem cell sheets and rhBMP-2-releasing calcium sulfate-rhBMP-2 scaffolds for segmental bone tissue engineering
    Yiying Qi
    Department of Orthopedic Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
    Cell Transplant 21:693-705. 2012
    ..The alkaline phosphatase (ALP) of MSCs cultured on rhBMP-2-loaded CS was significantly higher than that of CS at both 7 and 14 days (p < 0...
  92. pmc Hyaluronic acid-based hydrogels functionalized with heparin that support controlled release of bioactive BMP-2
    Gajadhar Bhakta
    Institute of Medical Biology, A STAR, 8A Biomedical Grove, 06 06 Immunos, Singapore 138648, Singapore
    Biomaterials 33:6113-22. 2012
    ..The osteogenic activity of BMP-2 released from the hydrogels was evaluated by monitoring alkaline phosphatase (ALP) activity and SMAD 1/5/8 phosphorylation in mesenchymal precursor cells...
  93. doi Hyperbilirubinemia in the early phase after allogeneic HSCT: prognostic significance of the alkaline phosphatase/total bilirubin ratio
    M Ashizawa
    Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama 330 8503, Japan
    Bone Marrow Transplant 48:94-8. 2013
    ..We focused on the serum alkaline phosphatase/total bilirubin ratio (ALP/TB) at the onset of hyperbilirubinemia and found that it significantly predicted the recovery from ..
  94. doi Metallofullerene nanoparticles promote osteogenic differentiation of bone marrow stromal cells through BMP signaling pathway
    Kangning Yang
    Laboratory of Nanomedicine and Nanosafety, Division of Nanomedicine and Nanobiology, National Center for Nanoscience and Technology of China, Chinese Academy of Sciences, no 11, First North Road, Zhongguancun, Beijing, 100190, China
    Nanoscale 5:1205-12. 2013
    ..the differentiation of MSCs toward osteoblasts, as evidenced by the enhancement of alkaline phosphatase (ALP) activity and mineralized nodule formation upon [Gd@C(82)(OH)(22)](n) nanoparticle treatment...
  95. doi Silk proteins stimulate osteoblast differentiation by suppressing the Notch signaling pathway in mesenchymal stem cells
    So Ra Jung
    Department of Food Science and Biotechnology, Sungkyunkwan University, Suwon, Korea
    Nutr Res 33:162-70. 2013
    ..We showed that silk proteins dose dependently stimulated alkaline phosphatase (ALP) activity, osteoblast differentiation, and induced expression of osteoblast markers in C3H10T1/2 and M2-10B4 ..
  96. doi Carbon-Ag/AgCl probes for detection of cell activity in droplets
    Kosuke Ino
    Graduate School of Environmental Studies, Tohoku University, Sendai 980 8579, Japan
    Anal Chem 85:3832-5. 2013
    ..HeLa cells were confined into a single droplet, and the alkaline phosphatase (ALP) activity of the cells was electrochemically measured using the probe inserted into the droplet...
  97. doi Osteocyte differentiation is regulated by extracellular matrix stiffness and intercellular separation
    C A Mullen
    Centre for Biomechanics Research BMEC, Mechanical and Biomedical Engineering, NUI Galway, Ireland National Centre for Biomedical Engineering Science NCBES, NUI Galway, Ireland
    J Mech Behav Biomed Mater 28:183-94. 2013
    ..Cells were evaluated for morphology, alkaline phosphatase (ALP), matrix mineralisation, osteoblast specific genes (Type 1 collagen, Osteoblast specific factor (OSF-2)), and ..
  98. doi Diosbulbin B-induced liver injury in mice and its mechanism
    Yibo Ma
    The MOE Key Laboratory for Standardization of Chinese Medicines and The Shanghai Key Laboratory for Compound Chinese medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China Department of Pharmacognosy, China Pharmaceutical University, Nanjing, China
    Hum Exp Toxicol 33:729-36. 2014
    ..activity of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP)...
  99. doi Osteoactivin promotes osteoblast adhesion through HSPG and αvβ1 integrin
    Fouad M Moussa
    Department of Anatomy and Neurobiology, Northeast Ohio Medical University NEOMED, Rootstown, Ohio School of Biomedical Sciences, Kent State University, Kent, Ohio
    J Cell Biochem 115:1243-53. 2014
    ..OA induced osteoblast differentiation and function in vitro by stimulating alkaline phosphatase (ALP) activity, osteocalcin production, nodule formation, and matrix mineralization...
  100. ncbi [A new method of isolating and culturing rabbit osteoblasts in vitro]
    Meizhen Yin
    School of Medicine, Hubei Institute of Technology, Huangshi 435003, China
    Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 30:1063-6. 2013
    ..staining and alizarin red staining for the third generation of osteoblasts to detect the alkaline phosphatase (ALP) expression and calcified nodules...
  101. doi Magnesium ions facilitate integrin alpha 2- and alpha 3-mediated proliferation and enhance alkaline phosphatase expression and activity in hBMSCs
    Yea Hyun Leem
    Department of Pharmacy, College of Pharmacy, Dankook University, Cheonan si, Chungnam, Korea
    J Tissue Eng Regen Med 10:E527-E536. 2016
    ..Magnesium exposure profoundly enhanced alkaline phosphatase (ALP) gene expression and activity even at a relatively low magnesium concentration (2.5 mm)...

Research Grants69

  1. STEVEN R MUMM; Fiscal Year: 2014
    ..The patient had never been diagnosed with HPP, although her serum ALP was low (26 U/L, Nl 32 - 116 U/L)...
  2. Xianzhong Meng; Fiscal Year: 2015
    ..a major role in TLR4-induced osteogenic responses, characterized by expression of Runx2, alkaline phosphatase (ALP) and osteopontin...
  3. Purinergic receptors in inflammation
    Wolfgang G Junger; Fiscal Year: 2012
    ..are recruited to the leading edge where adenosine is generated by CD39/E- NTPDase1 and alkaline phosphatase (ALP)...
  4. MINERALIZATION STUDIES RELATED TO ORAL BIOLOGY
    HARRISON ANDERSON; Fiscal Year: 2005
    ..We and others have provided evidence that MV phosphatases, including alkaline phosphatase (ALP), and ATPase are involved in MV mineralization...
  5. MOLECULAR BASIS OF PRONEPHRIC DUCT CELL GUIDANCE
    MALCOLM STEINBERG; Fiscal Year: 1991
    ..The molecule is identified as the cell-surface enzyme alkaline phosphatase (ALP). A prime focus of this project is to understand the role of ALP in guiding migrating embryonic cells...
  6. GROWTH FACTORS AND SKELETAL AGING
    Theresa Chen; Fiscal Year: 2000
    ..the bone forming potential of the osteoblasts is in direct proportion to the number of alkaline phosphatase (ALP) positive CFU-F...
  7. ID2 IN CELL CYCLE REGULATION AND CANCER
    Antonio Iavarone; Fiscal Year: 2010
    ..We identified the cytoplasmic, actin- associated protein ENH (ENigma Homolog) as a new Id2 protein partner...
  8. Xiaobin Wang; Fiscal Year: 2014
    ..outcomes, including (1) hormone dysfunction: reduced estrogen excretion (REE), anovulation, abnormal luteal phase (ALP), and abnormal follicular phase (AFP);(2) menstrual disorders;(3) infertility;(4) EPL and SAB;and (5) adverse birth ..
  9. Francesca Tentori; Fiscal Year: 2015
    ..These resources will be complemented by those at VUMC, including close mentorship by Dr. T. Alp Ikizler, interactions with other patient-oriented researchers and clinicians, and a vibrant scientific environment...
  10. Kelly A Birdwell; Fiscal Year: 2015
    ..My CTSA mentor, Dr. T. Alp Ikizler, is an internationally recognized leader on the metabolic complications of kidney disease and expert in the ..
  11. Effects of resistant starch on lipid and glucose metabolism in insulin resistance
    RONALD M contact KRAUSS; Fiscal Year: 2010
    ..with CVD risk in insulin resistant individuals who express components of the atherogenic lipoprotein phenotype (ALP)...
  12. Cellular Mechanisms of Neuropathology in Parkinson's Disease
    John J Shacka; Fiscal Year: 2013
    ..The autophagy- lysosome pathway (ALP) is an important intracellular degradation and recycling pathway and a compromise in ALP function promotes the ..
  13. Jacqui Smith; Fiscal Year: 2015
    ..PSID), the American Time Use Survey's (ATUS) new well-being module, and the American Life Panel's (ALP) DRM...
  14. ORGANOPHOSPHATE PESTICIDES AND HUMAN REPRODUCTIVE HEALTH
    Xiping Xu; Fiscal Year: 2003
    ..3) alterations in hormone patterns including reduced estrogen excretion (REE), anovulation, abnormal luteal phase (ALP), and abnormal follicular phase (AFP) in women and abnormalities of LH, FSH, TSH, SHBG, inhibin-B and testosterone ..
  15. RICHARD DENNIS WADDELL; Fiscal Year: 2015
    ..training will focus on the research support needs identified at MUHAS via the MUHAS-UCSF Academic Learning Program (ALP), including grant application preparation and submission, pre- and post-award management, financial management, ..
  16. Sarjeet S Gill; Fiscal Year: 2016
    ..Our research showed Aedes receptor proteins include cadherin, alkaline phosphatases (ALP), and aminopeptidases (APNs)...
  17. ACTININ ASSOCIATED LIM PROTEIN & FSH MUSCULAR DYSTROPHY
    David Bredt; Fiscal Year: 2002
    ..Recent molecular cloning studies have identified actinin-associated LIM protein (ALP), which is a novel component of the muscle cytoskeleton...
  18. DDT, Endocrine Disruption and Reproductive Outcomes
    Xiaobin Wang; Fiscal Year: 2003
    ..with (1) hormone dysfunction including reduced estrogen excretion (REE), anovulation, abnormal luteal phase (ALP), and abnormal follicular phase (AFP); (2) menstrual disorders; (3) reduced fecundability; and (4) adverse ..
  19. Mireille Jacobson; Fiscal Year: 2014
    ..on the actual and perceived financial risk associated with health spending from the RAND American Life Panel (ALP)...
  20. ARIE KAPTEYN; Fiscal Year: 2015
    ..To that end we will conduct several experiments in two population representative Internet panels: the American Life Panel (ALP) in the U.S. and the Longitudinal Internet Studies for the Social sciences (LISS) panel in The Netherlands.
  21. REGULATION OF ADENINE NUCLEOTIDE POOLS
    Vern Schramm; Fiscal Year: 1993
    ..Regulation of AMP deaminase is similar to AMP nucleosidase by allosteric activation with ALP and inhibition by Pi. No prokaryotes have been found to contain AMP nucleosidase...
  22. REGULATION OF CECROPIN AND ATTACIN GENE EXPRESSION
    Peter Dunn; Fiscal Year: 1991
    ..control to peptidoglycan regulation of fat body cecropin-like protein (CLP) and attacin-like protein (ALP) synthesis; (2) to isolate and characterize M...
  23. Antibody- and peptide-inhibitors of quorum sensing
    Kim Janda; Fiscal Year: 2004
    ..Our proposed work includes the following aims: (1) synthesis of quorum sensing peptides and analogs from all 4 AlP subgroups of S...
  24. ALKYLLYSOPHOSPHOLIPIDS AS ANTITUMOR AGENTS
    David Lawrence; Fiscal Year: 1990
    ..We are currently investigating the synthesis of a series of alkyllysophospholipid-photosensitizers (ALP-photosensitizers) where the ALP component will serve as a vehicle for the selective delivery of the sensitizer ..
  25. ANTINEOPLASTIC ALKYLGLYCEROLIPIDS
    CLAUDE PIANTADOSI; Fiscal Year: 1990
    ..The preliminary in vitro data that contributed to the funding of these grants was obtained on small amounts of ALP analogues that were synthesized utilizing funds from other sources...
  26. Neuroendocrine Regulation of GnRH Release
    Jon Levine; Fiscal Year: 2006
    ..The K+ATP channel closes upon binding AlP, leading to reduced cellular K+ permeability, membrane depolarization and thus, increased cell excitability; ..
  27. Biogenesis of the T. brucei Mitochondrial ATP Synthase
    Noreen Williams; Fiscal Year: 2006
    ..brucel mitochondrial AlP synthase? 3. What is the effect of decreasing the level of the mitochondrial ATP synthase in bloodstream forms? 4...
  28. Control of cell polarity in the C. elegans zygote
    Geraldine Seydoux; Fiscal Year: 2005
    ..Establishment of the anterior-posterior (AlP) body axis of C. elegans depends on polarization of the zygote shortly after fertilization...
  29. ATHEROSCLEROTIC LESION PHANTOM (ALP) FOR MRI/A
    Thomas Burke; Fiscal Year: 2001
    ..The long term goal of this project is to develop an Atherosclerotic Lesion Phantom (ALP) to assist the MRI community develop non invasive applications to identify patients at risk for clinically acute CV ..
  30. Structure and function of muscle
    Mary Beckerle; Fiscal Year: 2005
    ..We have identified members of two families of LIM domain proteins, the Cysteine-Rich Protein (CRP) family and the ALP-Enigma family as a-actinin binding partners...
  31. CRANIOFACIAL SKELETON-OSTEOBLASTIC GENE EXPRESSION
    Joseph Zernik; Fiscal Year: 1993
    Alkaline phosphatase (ALP) is the earliest known marker of osteoblastic differentiation. The proposed studies use ALP expression to investigate mesenchymal-osteoblastic differentiation during rat mandibular development...
  32. Molecular analysis of the dimeric F1/F0-ATP synthase
    Rosemary Stuart; Fiscal Year: 2006
    ..Isolation of the dimeric AlP synthase complex led to the identification of three new subunits of the complex...
  33. Staphylococcal Pathogenesis and Gene Expression
    Jesse Wright; Fiscal Year: 2003
    ..The agr locus encodes a two-component system composed of AgrC and A, and its autoinducing ligand (ALP), encoded by AgrD and processed by AgrB; its primary function is to activate the expression of a regulatory RNA ..
  34. Mechanism of helicase translocation along ss DNA
    Christopher Fischer; Fiscal Year: 2003
    ..The focus of this proposal is to characterize the kinetic mechanism for AlP binding and hydrolysis by Rep monomers bound to ss DNA and to determine whether Rep monomers are, indeed, capable ..
  35. MODULATION OF TGF-BETA/BMP ACTIVITY IN DEVELOPMENT
    Kavita Arora; Fiscal Year: 2005
    ..We will approach this issue by investigating the phenotype and delineating the receptor specificity and signaling pathway utilized by a novel TGF-B related ligand Alp that we have recently characterized.
  36. Global vs. Focal Neuroimaging Markers of Dementia Risk
    Caterina Rosano; Fiscal Year: 2007
    ..markers of Alzheimer Disease (AD) using an automated brain MRI reading technique, the automated labeling pathway (ALP)...
  37. STEROID INDUCED CHANGES IN CULTURED MALIGNANT CELLS
    GEORGE MELNYKOVYCH; Fiscal Year: 1993
    This research project is an integrated study of the effects of alkylphospholipids (ALP) and glucocorticoid steroid dexamethasone on cell lines derived from malignant tumors...
  38. Structural Analysis of the ATP Synthase Membrane Domain
    Mark Girvin; Fiscal Year: 2004
    The F1F0 ATP synthase is responsible for synthesizing the vast majority of cellular AlP. Not surprisingly, deleterious mutations in genes of the ATP synthase lead to inherited disorders, especially of nerves and muscles...
  39. ATHEROSCLEROTIC LESION PHANTOM (ALP) FOR MRI/A
    Thomas Burke; Fiscal Year: 2006
    ..Advanced ALP phantoms, properly employed, will help achieve statistically conclusive results speeding the development of ..
  40. APOPTOSIS AND A NEW ADAPTER MOLECULE PATHWAY IN GLIOMA
    Oliver Bogler; Fiscal Year: 2004
    ..SETA binds AlP!, a regulator of apoptosis and binding partner of ALG-2, which is itself required for apoptosis...
  41. RAPAMYCIN BLOCKADE OF PROTEIN PHOSPHATASE SIGNALING
    DAVID BRAUTIGAN; Fiscal Year: 2007
    ..Define the structural determinants required for interaction between human alpha-4 (TAP42) and its binding partner AlP (TIP41) using transient expression of truncated and mutated proteins and co-precipitation...
  42. Targeting Gene Therapy to Bladder Cancer
    GRAEME DOUGHERTY; Fiscal Year: 2005
    ..in which alternative splicing is used as a means of targeting the expression of the enzyme alkaline phosphatase (ALP) to tumor cells in vivo...
  43. A BABOON MODEL FOR THE GENETICS OF CORTICAL BONE MATERIAL PROPERTIES
    LORENA HAVILL; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  44. Regulation of Vascular Calcification in Diabetes
    XUENING CHEN; Fiscal Year: 2007
    ....
  45. OSTEOCALCIN SYNTHESIS AND CATABOLISM
    Caren Gundberg; Fiscal Year: 2007
    ..Osteoclast and/or osteoblast progenitors will be evaluated in bone marrow cells. ..
  46. TWO X-LINKED GENES THAT REGULATE MINERAL HOMEOSTASIS
    Michael Whyte; Fiscal Year: 2002
    ....
  47. Group B Strep Alp Protein-Epithelial Cell Interaction
    MIRIAM BARON BARSHAK; Fiscal Year: 2008
    ..These data support a hypothesis that Alps trigger actin-dependent internalization of GBS through interaction of an Alp N-terminal domain with an epithelial receptor. The specific aims of this proposal are 1...
  48. Regulation of Heme Uptake and Transport in Caco-2 Cells
    Aliye Uc; Fiscal Year: 2007
    ..g. hereditary hemochromatosis, iron overload secondary to blood transfusions) and explore the role of intestinal epithelial cell bi-directional heme movement on the regulation of iron stores. ..
  49. GENERAL CLINICAL RESEARCH CENTERS ANNUAL MEETING
    Paul Watkins; Fiscal Year: 2006
    ..abstract_text> ..
  50. Validating microRNA Analysis in Human Postmortem Brain
    Yogesh Dwivedi; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  51. Development of a Multi-phased Scaffold for Soft Tissue to Bone Integration
    Helen Lu; Fiscal Year: 2006
    ..abstract_text> ..
  52. Small RNAs in skeletogenesis
    Tatsuya Kobayashi; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  53. PI3K in LPS-induced coagulation and inflammation
    James Luyendyk; Fiscal Year: 2006
    ..Ultimately, characterization of the involvement of this pathway in LPS-induced inflammation may allow for development of novel strategies that can be used to treat sepsis. [unreadable] [unreadable] [unreadable]..
  54. Persistent changes in brain expression after withdrawal
    KRISTINE WIREN; Fiscal Year: 2003
    ..e. physical dependence leading to withdrawal seizures) are regulated at the genetic level. This knowledge may help in the development of new strategies for the treatment of alcohol dependence. ..
  55. GENE CAUSING PAGET & LIMB-GIRDLE MUSCULAR DYSTROPHY
    Virginia Kimonis; Fiscal Year: 2003
    ..Delineation of the genetic component responsible for the LGMD/PDB phenotype should promise similar insight and facilitate in the design of novel treatment protocols for the two disorders. ..
  56. OSTEOCLASTIC PHOSPHOTYROSYL PHOSPHATASE AND RESORPTION
    KIN HING LAU; Fiscal Year: 2002
    ....
  57. Bone Repair by Allogenic MSC in Non-ablated Animal
    Jueren Lou; Fiscal Year: 2004
    ..2. To investigate the fate of implanted allogeneic MSC in femur defect site of non-ablated rats. The ultimate goal of this proposal is to develop percutaneous injection procedure to facilitate bone repair. ..
  58. Genetic basis of myopathy with Paget disease of bone
    Virginia Kimonis; Fiscal Year: 2008
    ..e. effect on ATPase activity, protein-protein interactions, and hexamer formation). Study the VCP specific pathways in C2C12 cell lines (stably transfected wt and R155H VCP) during differentiation and under stress conditions...
  59. POSTRECEPTOR DYSREGULATION IN DEPRESSION
    Yogesh Dwivedi; Fiscal Year: 2004
    ..abstract_text> ..
  60. Sequential Release of Growth Factors for Bone Formation
    Jonathan Leach; Fiscal Year: 2004
    ..Vascularization and bone formation will be compared to several control groups. ..
  61. Androgen action in bone: Overexpression of AR
    Kristine M Wiren; Fiscal Year: 2010
    ..These studies will identify specific molecular events/pathways influenced by androgen treatment in bone, and should lead to an improved understanding of mechanisms that influence adult bone size and quality. ..
  62. Characterization of Pancreatic Disease in a Novel Porcine Cystic Fibrosis Model
    Aliye Uc; Fiscal Year: 2010
    ..The goal of this application is to fully characterize pancreatic involvement in our novel CF pig model and to better understand the pathophysiological mechanisms leading to PI in CF. ..
  63. CONTROL OF OSTEOGENESIS AND ADIPOGENESIS BY EBF
    Mark C Horowitz; Fiscal Year: 2010
    ..Such information would be applicable to a wide variety of skeletal defects including age-related osteopenia, post-menopausal osteoporosis, fracture repair, and extended survival of prosthetic implants. ..
  64. REGULATION OF BONE REMODELING BY MEGAKARYOCYTES
    Mark Horowitz; Fiscal Year: 2009
    ..Such information would be applicable to a wide variety of skeletal defects including, post-menopausal osteoporosis, age-related osteopenia, fracture repair, and extended survival of prosthetic implants. ..
  65. Effect of estrogen on bone tissue engineering
    Liu Hong; Fiscal Year: 2008
    ..We will investigate estradiol to modulate MSCs-based tissue engineered constructs in vitro and to improve the bone formation and osteo-integration in osteoporotic environments. [unreadable] [unreadable] [unreadable]..
  66. Signal Transduction Mechanisms in Suicide Brain
    Yogesh Dwivedi; Fiscal Year: 2008
    ..abstract_text> ..
  67. Breast Cancer Prevention and Treatment with Noni juice
    Mian Ying Wang; Fiscal Year: 2007
    ..The latency, multiplicity, volume of tumors, and the survivor rate of animals at the end of experiment will be evaluated in different groups. ..
  68. Characterization of Familial Myopathy & Paget Disease
    Virginia Kimonis; Fiscal Year: 2005
    ..Elucidation of the genetic defect will help us understand the pathogenesis of this multifaceted disorder and hopefully result in specific therapy. ..