PDGFR beta

Summary

Gene Symbol: PDGFR beta
Description: platelet derived growth factor receptor beta
Alias: CD140B, IBGC4, IMF1, JTK12, KOGS, PDGFR, PDGFR-1, PDGFR1, PENTT, CD140 antigen-like family member B, PDGF-R-beta, PDGFR-beta, beta-type platelet-derived growth factor receptor, platelet-derived growth factor receptor 1, platelet-derived growth factor receptor, beta polypeptide
Species: human

Top Publications

  1. pmc Neuropilin-1 promotes cirrhosis of the rodent and human liver by enhancing PDGF/TGF-beta signaling in hepatic stellate cells
    Sheng Cao
    Gastroenterology Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Invest 120:2379-94. 2010
  2. ncbi Five isoforms of the phosphatidylinositol 3-kinase regulatory subunit exhibit different associations with receptor tyrosine kinases and their tyrosine phosphorylations
    K Inukai
    Third Dept of Internal Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    FEBS Lett 490:32-8. 2001
  3. pmc Platelet-derived growth factor receptors differentially inform intertumoral and intratumoral heterogeneity
    Youngmi Kim
    Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Genes Dev 26:1247-62. 2012
  4. pmc Mesenchymal stem cell migration is regulated by fibronectin through α5β1-integrin-mediated activation of PDGFR-β and potentiation of growth factor signals
    Jennifer Veevers-Lowe
    Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
    J Cell Sci 124:1288-300. 2011
  5. pmc A recurrent PDGFRB mutation causes familial infantile myofibromatosis
    Yee Him Cheung
    Department of Pediatrics, Columbia University, New York, NY 10032, USA
    Am J Hum Genet 92:996-1000. 2013
  6. pmc Mutations in PDGFRB cause autosomal-dominant infantile myofibromatosis
    John A Martignetti
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029, USA Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA Electronic address
    Am J Hum Genet 92:1001-7. 2013
  7. doi A signaling cascade mediated by ceramide, src and PDGFRβ coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1
    Christel Cinq-Frais
    INSERM UMR 1048, I2MC, Toulouse, France
    Biochim Biophys Acta 1831:1344-56. 2013
  8. ncbi Role of caveolin-1 in p42/p44 MAP kinase activation and proliferation of human airway smooth muscle
    Reinoud Gosens
    Department of Physiology, University of Manitoba, Winnipeg, Canada
    Am J Physiol Lung Cell Mol Physiol 291:L523-34. 2006
  9. pmc PDGFRβ expression and function in fibroblasts derived from pluripotent cells is linked to DNA demethylation
    Kyle J Hewitt
    Program in Cell, Molecular and Developmental Biology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA
    J Cell Sci 125:2276-87. 2012
  10. ncbi Binding of Cbl to a phospholipase Cgamma1-docking site on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulation
    Alagarsamy Lakku Reddi
    Division of Molecular Oncology, Evanston Northwestern Healthcare Research Institute, Northwestern University, Evanston, Illinois 60201, USA
    J Biol Chem 282:29336-47. 2007

Detail Information

Publications252 found, 100 shown here

  1. pmc Neuropilin-1 promotes cirrhosis of the rodent and human liver by enhancing PDGF/TGF-beta signaling in hepatic stellate cells
    Sheng Cao
    Gastroenterology Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Invest 120:2379-94. 2010
    ....
  2. ncbi Five isoforms of the phosphatidylinositol 3-kinase regulatory subunit exhibit different associations with receptor tyrosine kinases and their tyrosine phosphorylations
    K Inukai
    Third Dept of Internal Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    FEBS Lett 490:32-8. 2001
    ..When overexpressed in CHO-PDGFR cells, the associations of these regulatory subunit isoforms with the platelet-derived growth factor receptor were ..
  3. pmc Platelet-derived growth factor receptors differentially inform intertumoral and intratumoral heterogeneity
    Youngmi Kim
    Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Genes Dev 26:1247-62. 2012
    ..While PDGFRα alterations inform intertumoral heterogeneity toward a proneural glioblastoma (GBM) subtype, we interrogated the ..
  4. pmc Mesenchymal stem cell migration is regulated by fibronectin through α5β1-integrin-mediated activation of PDGFR-β and potentiation of growth factor signals
    Jennifer Veevers-Lowe
    Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
    J Cell Sci 124:1288-300. 2011
    ..Here, we report extracellular matrix (ECM)-directed crosstalk between platelet-derived growth factor receptor (PDGFR)-β and α5β1-integrin, which controls the migration of mesenchymal stem (stromal) cells (MSCs)...
  5. pmc A recurrent PDGFRB mutation causes familial infantile myofibromatosis
    Yee Him Cheung
    Department of Pediatrics, Columbia University, New York, NY 10032, USA
    Am J Hum Genet 92:996-1000. 2013
    ..b>PDGFR-β promotes growth of mesenchymal cells, including blood vessels and smooth muscles, which are affected in IM...
  6. pmc Mutations in PDGFRB cause autosomal-dominant infantile myofibromatosis
    John A Martignetti
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029, USA Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA Electronic address
    Am J Hum Genet 92:1001-7. 2013
    ....
  7. doi A signaling cascade mediated by ceramide, src and PDGFRβ coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1
    Christel Cinq-Frais
    INSERM UMR 1048, I2MC, Toulouse, France
    Biochim Biophys Acta 1831:1344-56. 2013
    ..Further results implicated src and the trans-activation of PDGFRβ, as supported by the blocking effect of specific siRNAs, pharmacological inhibitors, and genetically deficient ..
  8. ncbi Role of caveolin-1 in p42/p44 MAP kinase activation and proliferation of human airway smooth muscle
    Reinoud Gosens
    Department of Physiology, University of Manitoba, Winnipeg, Canada
    Am J Physiol Lung Cell Mol Physiol 291:L523-34. 2006
    ..As such, caveolae and caveolin-1 coordinate PDGF receptor signaling, leading to myocyte proliferation, and inhibit constitutive activity of p42/p44 MAPK to sustain cell quiescence...
  9. pmc PDGFRβ expression and function in fibroblasts derived from pluripotent cells is linked to DNA demethylation
    Kyle J Hewitt
    Program in Cell, Molecular and Developmental Biology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA
    J Cell Sci 125:2276-87. 2012
    Platelet-derived growth factor receptor-beta (PDGFRβ) is required for the development of mesenchymal cell types, and plays a diverse role in the function of fibroblasts in tissue homeostasis and regeneration...
  10. ncbi Binding of Cbl to a phospholipase Cgamma1-docking site on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulation
    Alagarsamy Lakku Reddi
    Division of Molecular Oncology, Evanston Northwestern Healthcare Research Institute, Northwestern University, Evanston, Illinois 60201, USA
    J Biol Chem 282:29336-47. 2007
    ..Cbl as an E3 ubiquitin ligase for ubiquitinylation and degradation of platelet-derived growth factor receptor (PDGFR) alpha and PDGFRbeta...
  11. doi Phenotypic spectrum of probable and genetically-confirmed idiopathic basal ganglia calcification
    Gael Nicolas
    1 Inserm U1079, Rouen, France
    Brain 136:3395-407. 2013
    ..Other biomarkers may be helpful in better predicting clinical expression. ..
  12. doi Mutation of the PDGFRB gene as a cause of idiopathic basal ganglia calcification
    Gael Nicolas
    Inserm U1079, University Hospital and Faculty of Medicine, Rouen
    Neurology 80:181-7. 2013
    ..To identify a new idiopathic basal ganglia calcification (IBGC)-causing gene...
  13. pmc Genetic screening and functional characterization of PDGFRB mutations associated with basal ganglia calcification of unknown etiology
    Mónica Sánchez-Contreras
    Department of Neuroscience, Mayo Clinic, Jacksonville, Florida
    Hum Mutat 35:964-71. 2014
    ..of the platelet-derived growth factor receptor family type β, and PDGFB, encoding PDGF-B, the specific ligand of PDGFRβ, were found implicating the PDGF-B/PDGFRβ pathway in abnormal brain calcification...
  14. ncbi Alix facilitates the interaction between c-Cbl and platelet-derived growth factor beta-receptor and thereby modulates receptor down-regulation
    Johan Lennartsson
    Ludwig Institute for Cancer Research, Uppsala University, Biomedical Center, SE 751 24 Uppsala, Sweden
    J Biol Chem 281:39152-8. 2006
    ..Our data suggest that Alix inhibits down-regulation of PDGFRbeta by modulating the interaction between c-Cbl and the receptor, thereby affecting the ubiquitination of the receptor...
  15. doi 5-HT(1A) receptors transactivate the platelet-derived growth factor receptor type beta in neuronal cells
    Jeff S Kruk
    Department of Biology, University of Waterloo, Canada
    Cell Signal 25:133-43. 2013
    ..This crosstalk between 5-HT and PDGFβ receptors identifies a potentially important signaling link between the serotonergic system and growth factor signaling in neurons...
  16. pmc PDGFRα/β and VEGFR2 polymorphisms in colorectal cancer: incidence and implications in clinical outcome
    Purificacion Estevez-Garcia
    Instituto de Biomedicina de Sevilla IBIS HUVR, CSIC, Universidad de Sevilla, Sevilla, Spain
    BMC Cancer 12:514. 2012
    ..VEGFR and PDGFR are key players involved in this process...
  17. ncbi Site-selective dephosphorylation of the platelet-derived growth factor beta-receptor by the receptor-like protein-tyrosine phosphatase DEP-1
    M Kovalenko
    Ludwig Institute for Cancer Research, Box 595, S 751 24, Uppsala, Sweden
    J Biol Chem 275:16219-26. 2000
    ..Our study demonstrates that DEP-1 dephosphorylation of the PDGF beta-receptor is site-selective and may lead to modulation, rather than general attenuation, of signaling...
  18. pmc Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors
    A Arcaro
    Ludwig Institute for Cancer Research, University College, London W1P 8BT, United Kingdom
    Mol Cell Biol 20:3817-30. 2000
    ..We conclude that class II PI3K enzymes may contribute to the generation of 3' phosphoinositides following the activation of polypeptide growth factor receptors in vivo and thus mediate certain aspects of their biological activity...
  19. pmc Critical role of the platelet-derived growth factor receptor (PDGFR) beta transmembrane domain in the TEL-PDGFRbeta cytosolic oncoprotein
    Federica Toffalini
    Universite Catholique de Louvain, de Duve Institute, BE 1200 Brussels, Belgium
    J Biol Chem 285:12268-78. 2010
    The fusion of TEL with platelet-derived growth factor receptor (PDGFR) beta (TPbeta) is found in a subset of patients with atypical myeloid neoplasms associated with eosinophilia and is the archetype of a larger group of hybrid receptors ..
  20. ncbi Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation
    Kaisa Haglund
    Ludwig Institute for Cancer Research, Husargatan 3, SE 75 124 Uppsala, Sweden
    Nat Cell Biol 5:461-6. 2003
    ..Thus, monoubiquitination is the principal signal responsible for the movement of RTKs from the plasma membrane to the lysosome...
  21. pmc The fusion proteins TEL-PDGFRbeta and FIP1L1-PDGFRalpha escape ubiquitination and degradation
    Federica Toffalini
    Universite Catholique de Louvain, de Duve Institute, Brussels, Belgium
    Haematologica 94:1085-93. 2009
    ..Since protein degradation pathways have been identified as useful targets for cancer therapy, the aim of this study was to compare the degradation of hybrid and wild-type receptor tyrosine kinases...
  22. ncbi Signal transduction via platelet-derived growth factor receptors
    C H Heldin
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden
    Biochim Biophys Acta 1378:F79-113. 1998
    ..Recent observations suggest that extensive cross-talk occurs between different signaling pathways, and that stimulatory signals are modulated by inhibitory signals arising in parallel...
  23. pmc HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death
    A Bardelli
    Institute for Cancer Research I R C C, University of Torino School of Medicine, Italy
    EMBO J 15:6205-12. 1996
    ..The finding of a link between growth factor receptors and the anti-apoptotic machinery fills a gap in the understanding of the molecular events regulating programmed cell death...
  24. pmc Bone-metastatic potential of human prostate cancer cells correlates with Akt/PKB activation by alpha platelet-derived growth factor receptor
    Nathan G Dolloff
    Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Oncogene 24:6848-54. 2005
    ..This difference in PDGF responsiveness depends on the higher expression of alpha-PDGFR in bone-metastatic compared to nonmetastatic prostate cells and the lack of alpha-PDGFR expression in normal and ..
  25. pmc A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion
    Y Fujioka
    Second Department of Internal Medicine, Kobe University School of Medicine, Chuo Ku, Japan
    Mol Cell Biol 16:6887-99. 1996
    ..In addition, we suggest that SHPS-1 may be a potential substrate for SHP-2 and may function in both growth factor- and cell adhesion-induced cell signaling...
  26. pmc Clinicopathological significance of platelet-derived growth factor (PDGF)-B and vascular endothelial growth factor-A expression, PDGF receptor-β phosphorylation, and microvessel density in gastric cancer
    Shioto Suzuki
    Department of Molecular and Cellular Pathology, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
    BMC Cancer 10:659. 2010
    ..was to define: i) the expression pattern of VEGF-A and PDGF-B in tumor cells and the activation of PDGF receptor (PDGFR)-β tyrosine kinase in stromal cells of human gastric adenocarcinomas; and ii) the relationship between VEGF-A and ..
  27. pmc A novel signaling axis of matriptase/PDGF-D/ß-PDGFR in human prostate cancer
    Carolyn V Ustach
    Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University, School of Medicine, Detroit, Michigan 48201, USA
    Cancer Res 70:9631-40. 2010
    Increasing evidence indicates the significance of platelet-derived growth factor receptor-β (β-PDGFR) signaling in prostate cancer (PCa)...
  28. ncbi Sphingosine 1-phosphate and platelet-derived growth factor (PDGF) act via PDGF beta receptor-sphingosine 1-phosphate receptor complexes in airway smooth muscle cells
    Catherine Waters
    Department of Physiology and Pharmacology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, 27 Taylor St, Glasgow, G4 0NR, Scotland, United Kingdom
    J Biol Chem 278:6282-90. 2003
    ....
  29. ncbi Two different subunits associate to create isoform-specific platelet-derived growth factor receptors
    R A Seifert
    Department of Pathology, University of Washington, Seattle 98195
    J Biol Chem 264:8771-8. 1989
    ..Both the absolute and relative numbers of these two PDGF receptor subunits vary on different cell types and correspond to differences in the mitogenic sensitivity of cells to the different PDGF isoforms...
  30. pmc Negative regulation of Ros receptor tyrosine kinase signaling. An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1
    H Keilhack
    Research Unit, Molecular Cell Biology, D 07747 Jena, Germany
    J Cell Biol 152:325-34. 2001
    ..Overexpression of SHP-1 results in Ros dephosphorylation and effectively downregulates Ros-dependent proliferation and transformation. We propose that SHP-1 is an important downstream regulator of Ros signaling...
  31. ncbi Phosphorylation of the platelet-derived growth factor receptor-beta and epidermal growth factor receptor by G protein-coupled receptor kinase-2. Mechanisms for selectivity of desensitization
    Neil J Freedman
    Department of Medicine Cardiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 277:48261-9. 2002
    ..Specificity of GRK2 for receptor protein-tyrosine kinases, expressed at physiologic levels, may be determined by the ability of these receptors to activate heterotrimeric G proteins, among other factors...
  32. ncbi Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II
    Min Hee Choi
    Division of Molecular Life Sciences and the Center for Cell Signaling Research, Ewha Womans University, Seoul 120 750, Korea
    Nature 435:347-53. 2005
    ..Prx II deficiency results in increased production of H2O2, enhanced activation of PDGF receptor (PDGFR) and phospholipase Cgamma1, and subsequently increased cell proliferation and migration in response to PDGF...
  33. ncbi Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck
    L E Braverman
    Department of Biochemistry and Molocular Biology and Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 274:5542-9. 1999
    ..Nck and Grb4 therefore appear to be functionally redundant...
  34. ncbi Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins
    T Karlsson
    Department of Medical Cell Biology, Uppsala University, Sweden
    Oncogene 10:1475-83. 1995
    ..PDGF treatment did not affect the association between Eps8 and Shb. The data suggest that Shb is an adaptor protein linking SH3 domain proteins to tyrosine kinases or other tyrosine phosphorylated proteins...
  35. ncbi Platelet-derived growth factor receptor beta and vascular endothelial growth factor receptor 2 bind to the beta 3 integrin through its extracellular domain
    E Borges
    Cancer Research Center, The Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 275:39867-73. 2000
    ..These results show that the interactions that lead to the association of the alpha(v)beta(3) integrin with PDGF-Rbeta and VEGF-R2 and enhancement of RTK activity take place outside the cell...
  36. ncbi Systematic evaluation of anti-apoptotic growth factor signaling in vascular smooth muscle cells. Only phosphatidylinositol 3'-kinase is important
    Marius Vantler
    Klinik III fur Innere Medizin, Universitat zu Koln, D 50924 Koln, Germany
    J Biol Chem 280:14168-76. 2005
    ..To bypass endogenous PDGFR in VSMC we used chimeric receptors (ChiRs), containing the extracellular domain of the macrophage colony-..
  37. doi Phase I dose escalation study of telatinib, a tyrosine kinase inhibitor of vascular endothelial growth factor receptor 2 and 3, platelet-derived growth factor receptor beta, and c-Kit, in patients with advanced or metastatic solid tumors
    Ferry A L M Eskens
    Department of Medical Oncology, Erasmus University Medical Center, PO Box 2040, Rotterdam, 3000 CA, The Netherlands
    J Clin Oncol 27:4169-76. 2009
    ..This phase I dose escalation study was conducted to evaluate the safety and tolerability of telatinib, with additional pharmacokinetic, pharmacodynamic, and efficacy assessments...
  38. ncbi TEL/platelet-derived growth factor receptor beta activates phosphatidylinositol 3 (PI3) kinase and requires PI3 kinase to regulate the cell cycle
    Jamil Dierov
    Division of Hematology and Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Blood 99:1758-65. 2002
    ..These studies demonstrate the presence of a signaling pathway from TEL/PDGF beta R to PI3 kinase and subsequently to regulation of the cdk4 kinase complex. Activation of this pathway is necessary for transformation by TEL/PDGF beta R...
  39. ncbi PDGFRalpha/beta expression correlates with the metastatic behavior of human colorectal cancer: a possible rationale for a molecular targeting strategy
    Thomas C Wehler
    Third Department of Internal Medicine, Johannes Gutenberg University of Mainz, 55101 Mainz, Germany
    Oncol Rep 19:697-704. 2008
    ..03). In summary, our results revealed that PDGFRalpha/beta expression significantly correlates with lymphatic dissemination and therefore encourages application of PDGFRalpha/beta RTK-inhibitors within a combination therapy...
  40. ncbi The p85alpha subunit of phosphatidylinositol 3'-kinase binds to and stimulates the GTPase activity of Rab proteins
    M Dean Chamberlain
    Cancer Research Unit, Health Research Division, Saskatchewan Cancer Agency, Saskatoon, Saskatchewan S7N 4H4, Canada
    J Biol Chem 279:48607-14. 2004
    ..or degradation of activated receptor tyrosine kinases such as the platelet-derived growth factor receptor (PDGFR)...
  41. pmc SH2 domains of the p85 alpha subunit of phosphatidylinositol 3-kinase regulate binding to growth factor receptors
    C J McGlade
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Mol Cell Biol 12:991-7. 1992
    ..The SH2 domains of p85 are therefore primarily responsible for the binding of PI 3-kinase to activated growth factor receptors...
  42. pmc Vav family proteins couple to diverse cell surface receptors
    S L Moores
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 20:6364-73. 2000
    ..Thus, although each Vav isoform can respond to similar cell surface receptors, there are isoform-specific differences in their activation of downstream signaling pathways...
  43. ncbi Platelet-derived growth factor receptor expression and amplification in choroid plexus carcinomas
    Nina N Nupponen
    Molecular Cancer Biology Program, University of Helsinki, Helsinki, Finland
    Mod Pathol 21:265-70. 2008
    ....
  44. ncbi Autoinhibition of the platelet-derived growth factor beta-receptor tyrosine kinase by its C-terminal tail
    Federica Chiara
    Ludwig Institute for Cancer Research, S 75124 Uppsala, Sweden
    J Biol Chem 279:19732-8. 2004
    ..These findings indicate that allosteric inhibition of the PDGF beta-receptor by its C-terminal tail is one of the mechanisms involved in keeping the receptor inactive in the absence of ligand...
  45. pmc cDNA cloning and expression of a human platelet-derived growth factor (PDGF) receptor specific for B-chain-containing PDGF molecules
    L Claesson-Welsh
    Ludwig Institute for Cancer Research, Uppsala Branch, Sweden
    Mol Cell Biol 8:3476-86. 1988
    ..Binding assays with different 125I-labeled dimeric forms of PDGF A and B chains showed that the PDGF receptor expressed in CHO cells bound PDGF-BB and, to a lesser extent, PDGF-AB, but not PDGF-AA...
  46. ncbi Dual targeting of IGF-1R and PDGFR inhibits proliferation in high-grade gliomas cells and induces radiosensitivity in JNK-1 expressing cells
    Mia Carapancea
    Department of Oncology Pathology, Cancer Center Karolinska and Radiumhemmet Karolinska Institute University Hospital, R8 00, Stockholm 171 76, Sweden
    J Neurooncol 85:245-54. 2007
    ..found co-expression of Insulin like growth factor-1 receptor (IGF-1R) and platelet derived growth factor receptor (PDGFR) in two high-grade gliomas (HGG) cell lines 18 and 38...
  47. ncbi Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-gamma 1 complexed with a high affinity binding peptide
    S M Pascal
    Biochemistry Research Division, Hospital for Sick Children, Toronto, Ontario, Canada
    Cell 77:461-72. 1994
    ....
  48. pmc Transactivation of PDGFRbeta by dopamine D4 receptor does not require PDGFRbeta dimerization
    Sum Shing Chi
    Department of Neuroscience, Centre for Addiction and Mental Health, University of Toronto, Toronto M5T 1R8, Canada
    Mol Brain 3:22. 2010
    ..Hence, the DRD4-PDGFRbeta-ERK1/2 pathway can occur independently of a PDGF-like ligand, PDGFRbeta cross-phosphorylation and dimerization, which is distinct from other known forms of transactivation of RTKs by GPCRs...
  49. doi Platelet-derived growth factor receptor signaling is not involved in osteogenic differentiation of human mesenchymal stem cells
    Akhilesh Kumar
    Department of Plastic and Hand Surgery, University of Freiburg Medical Center, Freiburg, Germany
    Tissue Eng Part A 16:983-93. 2010
    ..From these experiments, we conclude that PDGF receptor signaling sustains proliferation without affecting osteogenic differentiation of MSCs...
  50. ncbi Direct activation of the serine/threonine kinase activity of Raf-1 through tyrosine phosphorylation by the PDGF beta-receptor
    D K Morrison
    Department of Medicine, Howard Hughes Medical Institute, University of California, San Francisco 94143
    Cell 58:649-57. 1989
    ..This is the first demonstration of the direct modulation of a protein activity by a growth factor receptor tyrosine kinase...
  51. ncbi Differential interaction of CrkII adaptor protein with platelet-derived growth factor alpha- and beta-receptors is determined by its internal tyrosine phosphorylation
    T Matsumoto
    Second Department of Internal Medicine, Chiba University School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, 260 0856, Japan
    Biochem Biophys Res Commun 270:28-33. 2000
    ..The differential binding of CrkII to the PDGF alpha- and beta- receptors may be a rationale for functional diversity between the two receptors...
  52. ncbi Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors
    D Anderson
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Science 250:979-82. 1990
    ....
  53. ncbi Molecular analysis of PDGFRA and PDGFRB genes by rapid single-strand conformation polymorphism (SSCP) in patients with core-binding factor leukaemias with KIT or FLT3 mutation
    Alessandra Trojani
    Division of Hematology, Niguarda Hospital, Milan, Italy
    Anticancer Res 28:2745-51. 2008
    ..The aim of this study was to investigate if PDGFR mutations are involved in CBFL.
  54. pmc Cloning and expression of a cDNA coding for the human platelet-derived growth factor receptor: evidence for more than one receptor class
    R G Gronwald
    Department of Pathology SM 30, University of Washington, Seattle 98195
    Proc Natl Acad Sci U S A 85:3435-9. 1988
    ..This observation is consistent with the existence of more than one PDGF receptor class...
  55. ncbi HCMOGT-1 is a novel fusion partner to PDGFRB in juvenile myelomonocytic leukemia with t(5;17)(q33;p11.2)
    Cristina Morerio
    Dipartimento di Ematologia ed Oncologia Pediatrica, Istituto di Ricovero e Cura a Carattere Scientifico Istituto G Gaslini, Genova, Italy
    Cancer Res 64:2649-51. 2004
    ..We show that the breakpoint of PDGFRB occurred at the same site of all previously reported PDGFRB translocations...
  56. ncbi Binding to the platelet-derived growth factor receptor transiently activates the p85alpha-p110alpha phosphoinositide 3-kinase complex in vivo
    J Domin
    Ludwig Institute for Cancer Research, London, W1P 8BT, United Kingdom
    J Biol Chem 271:21614-21. 1996
    ....
  57. ncbi The epidermal growth factor receptor associates with and recruits phosphatidylinositol 3-kinase to the platelet-derived growth factor beta receptor
    A A Habib
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 273:6885-91. 1998
    ..Our findings indicate that direct interactions between receptor tyrosine kinases classified under different subfamilies may be more widespread than previously believed...
  58. ncbi [Mitogenesis of platelet-derived growth factors to human osteoblasts modulated by basic fibroblast growth factor]
    J Chen
    Department of Orthopeadic Surgery, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China
    Zhonghua Wai Ke Za Zhi 38:707-10. 2000
    ..After incubated with bFGF (10 ng/ml) for 24 hours, the number of PDGFR-alpha and PDGFR-beta on the membrane of the osteoblasts was detected by fluoroimmunoassay...
  59. ncbi Platelet-derived growth factor receptor-beta constitutive activity promotes angiogenesis in vivo and in vitro
    Peetra U Magnusson
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    Arterioscler Thromb Vasc Biol 27:2142-9. 2007
    ..for the platelet-derived growth factor-B and its cognate receptor, platelet-derived growth factor receptor-beta (PDGFR-beta), in blood vessel maturation, that is, the coverage of newly formed vessels with mural cells/pericytes...
  60. ncbi Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta
    Jane F Apperley
    Department of Haematology, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, United Kingdom
    N Engl J Med 347:481-7. 2002
    ..The tyrosine kinase inhibitor imatinib mesylate specifically inhibits ABL, PDGFR, and KIT kinases and has impressive clinical efficacy in BCR-ABL-positive chronic myeloid leukemia.
  61. doi Additive effects of hyperbaric oxygen and platelet-derived growth factor-BB in chondrocyte transplantation via up-regulation expression of platelet-derived growth factor-beta receptor
    Li Jen Yuan
    Department of Orthopaedic Surgery and Hyperbaric Oxygen Therapy Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    J Orthop Res 27:1439-46. 2009
    ..mRNA expression of the PDGF-alpha receptor (PDGFR-alpha) and beta receptor (PDGFR-beta) was detected by RT-PCR...
  62. pmc PDGFRA, PDGFRB, EGFR, and downstream signaling activation in malignant peripheral nerve sheath tumor
    Federica Perrone
    Experimental Molecular Pathology, Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy
    Neuro Oncol 11:725-36. 2009
    ....
  63. ncbi Antiangiogenic and antitumor activity of a selective PDGFR tyrosine kinase inhibitor, CP-673,451
    W Gregory Roberts
    Pfizer Oncology, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA
    Cancer Res 65:957-66. 2005
    CP-673,451 is a potent inhibitor of platelet-derived growth factor beta-receptor (PDGFR-beta) kinase- and PDGF-BB-stimulated autophosphorylation of PDGFR-beta in cells (IC(50) = 1 nmol/L) being more than 450-fold selective for PDGFR-beta ..
  64. pmc FIP1L1/PDGFR alpha-associated systemic mastocytosis
    Yoshiyuki Yamada
    Division of Allergy and Immunology, Gunma Children s Medical Center, Shibukawa, Gunma, Japan yamaday gcmc pref gunma jp
    Int Arch Allergy Immunol 152:101-5. 2010
    ..FIP1L1/PDGFR alpha-positive disorders are characterized by clonal hypereosinophilia, multiple organ dysfunctions due to ..
  65. ncbi Imatinib mesylate in chordoma
    Paolo G Casali
    Adult Sarcoma Medical Oncology Unit, Department of Cancer Medicine, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Cancer 101:2086-97. 2004
    ..To the authors' knowledge, no effective medical therapy currently is available for advanced chordoma. Imatinib mesylate is a tyrosine kinase inhibitor targeting platelet-derived growth factor receptor-beta (PDGFRB), BCR-ABL, and KIT...
  66. pmc Myeloproliferative disease induced by TEL-PDGFRB displays dynamic range sensitivity to Stat5 gene dosage
    Jennifer A Cain
    Department of Internal Medicine, Division of Oncology, Washington University Siteman Cancer Center, 550 S Euclid Avenue, St Louis, MO 63110, USA
    Blood 109:3906-14. 2007
    ..Together, these data demonstrate that Stat5a and Stat5b are dose-limiting mediators of TEL-PDGFRB-induced myeloproliferation...
  67. doi Activity of imatinib in systemic mastocytosis with chronic basophilic leukemia and a PRKG2-PDGFRB fusion
    Idoya Lahortiga
    Human Genome Laboratory, Department of Molecular and Developmental Genetics, VIB, Leuven, Belgium
    Haematologica 93:49-56. 2008
    ..We report an unusual case of a patient presenting with peripheral basophilia and systemic mastocytosis in whom cytogenetic analysis revealed a t(4;5)(q21.1;q31.3)...
  68. doi Primary eosinophilic disorders: a concise review
    Animesh Pardanani
    Division of Hematology, Mayo Clinic, Rochester, MN 55905, USA
    Curr Hematol Malig Rep 3:37-43. 2008
    ..chronic eosinophilic leukemia, not otherwise categorized (CEL-NOC); platelet-derived growth factor receptor (PDGFR)-rearranged myeloid neoplasms; and other myeloid malignancies associated with prominent blood eosinophilia...
  69. doi Pleomorphic phenotypes of gastrointestinal stromal tumors at metastatic sites with or without imatinib treatment
    Kazuha Sakamoto
    Department of Diagnostic Pathology, Graduate School of Medicine, Gunma University, Gunma, Japan
    Cancer Sci 101:1270-8. 2010
    ..A KIT-independent mechanism, such as activation of other RTKs, might participate in the proliferation of late-stage GISTs and might be a cause of secondary imatinib resistance...
  70. ncbi p73 competes with co-activators and recruits histone deacetylase to NF-Y in the repression of PDGF beta-receptor
    Hidetaka Uramoto
    Department of Cell Biology, Institute of Anatomy and Cell Biology, Goteborg University, Box 420, SE 405 30 Gothenburg, Sweden
    J Cell Sci 117:5323-31. 2004
    ..These results suggest that p73 and DeltaNp73 behave as physiological regulators for the transcription of the PDGFRB promoter...
  71. ncbi Clinical and molecular studies of the effect of imatinib on advanced aggressive fibromatosis (desmoid tumor)
    Michael C Heinrich
    Oregon Health and Science University Cancer Institute and Portland VA Medical Center, Portland, OR, USA
    J Clin Oncol 24:1195-203. 2006
    ..To determine the clinical efficacy of imatinib in patients with advanced aggressive fibromatosis (AF) and to identify the molecular basis of response/nonresponse to this agent...
  72. ncbi Durable responses to imatinib in patients with PDGFRB fusion gene-positive and BCR-ABL-negative chronic myeloproliferative disorders
    Marianna David
    Department of Haematology, University of Pecs, Pecs, Hungary
    Blood 109:61-4. 2007
    ..Our data show that durable hematologic and cytogenetic responses are achieved with imatinib in patients with PDGFRB fusion-positive, BCR-ABL-negative CMPDs...
  73. ncbi Deletion of the PDGFR-beta gene affects key fibroblast functions important for wound healing
    Zhiyang Gao
    Department of Pathology, Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    J Biol Chem 280:9375-89. 2005
    This study provides new perspectives of the unique aspects of platelet-derived growth factor beta-receptor (PDGFR-beta) signaling and biological responses through the establishment of a mutant mouse strain in which two loxP sequences ..
  74. pmc Molecular drug targets in myeloproliferative neoplasms: mutant ABL1, JAK2, MPL, KIT, PDGFRA, PDGFRB and FGFR1
    Ayalew Tefferi
    Division of Hematology, Mayo Clinic, Rochester, MN 55905, USA
    J Cell Mol Med 13:215-37. 2009
    Therapeutically validated oncoproteins in myeloproliferative neoplasms (MPN) include BCR-ABL1 and rearranged PDGFR proteins. The latter are products of intra- (e.g. FIP1L1-PDGFRA) or inter-chromosomal (e.g. ETV6-PDGFRB) gene fusions...
  75. doi Selective inhibition of PDGFR by imatinib elicits the sustained activation of ERK and downstream receptor signaling in malignant glioma cells
    Yucui Dong
    Department of Immunology, Harbin Medical University, Harbin 150081, PR China
    Int J Oncol 38:555-69. 2011
    ..In this study, we investigated the effects of imatinib on the platelet derived growth factor receptor (PDGFR) downstream signaling pathways as well as on other cellular functions in human glioblastoma cells...
  76. doi THOC5 spliceosome protein: a target for leukaemogenic tyrosine kinases that affects inositol lipid turnover
    Andrew Pierce
    Stem Cell and Leukaemia Proteomics Laboratory, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK
    Br J Haematol 141:641-50. 2008
    ..Thus, THOC5 is a novel target for modulation of signal transduction with a potential role in leukaemogenesis...
  77. ncbi An activating mutation in the PDGF receptor-beta causes abnormal morphology in the mouse placenta
    Camilla Looman
    Ludwig Institute for Cancer Research, Uppsala University, Uppsala, Sweden
    Int J Dev Biol 51:361-70. 2007
    ..In addition, the fetal blood vessel compartment of the labyrinth was completely disorganized...
  78. doi Characterization of neuroprogenitor cells expressing the PDGF beta-receptor within the subventricular zone of postnatal mice
    Yoko Ishii
    Institute of Biomedicine, Department of Medical Chemistry and Cell Biology, Goteborg University, Box 420, SE 405 30 Gothenburg, Sweden
    Mol Cell Neurosci 37:507-18. 2008
    ..Furthermore, the PDGFR kinase inhibitor STI571 blocked the effects of bFGF in control neurosphere cultures...
  79. pmc Inverse correlation between PDGFC expression and lymphocyte infiltration in human papillary thyroid carcinomas
    Ove Bruland
    Center of Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway
    BMC Cancer 9:425. 2009
    ..Finally, we investigated potential influence on PDGF mRNA levels by the presence of tumour-infiltrating lymphocytes...
  80. doi Receptor tyrosine kinase and downstream signalling analysis in diffuse malignant peritoneal mesothelioma
    Federica Perrone
    Experimental Molecular Pathology, Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori, Via G Venezian 1, 20133 Milano, Italy
    Eur J Cancer 46:2837-48. 2010
    ....
  81. ncbi Cell-type localization of platelet-derived growth factors and receptors in the postnatal rat ovary and follicle
    Leanne S Sleer
    Department of Biochemistry and Molecular and Cellular Biology, Vincent T Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA
    Biol Reprod 76:379-90. 2007
    ..presence and localization of all members of the family of platelet-derived growth factors (PDGF) and receptors (PDGFR) were identified and characterized in the rat ovary...
  82. pmc Cardiomyocyte PDGFR-beta signaling is an essential component of the mouse cardiac response to load-induced stress
    Vishnu Chintalgattu
    Department of Cardiology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Clin Invest 120:472-84. 2010
    b>PDGFR is an important target for novel anticancer therapeutics because it is overexpressed in a wide variety of malignancies...
  83. ncbi Expression and mutational status of PDGFR in thymic tumours
    Michael Meister
    Translational Research Unit, Thoraxklinik Heidelberg gGmbH, University of Heidelberg, Amalienstr 5, 69126 Heidelberg, Germany
    Anticancer Res 29:4057-61. 2009
    ..In this study, the possibility that platelet-derived growth factor receptor A (PDGFRA) and/ or PDGFRB may represent potential therapeutic targets in epithelial tumours of the thymus was investigated...
  84. doi Fusion of PDGFRB to two distinct loci at 3p21 and a third at 12q13 in imatinib-responsive myeloproliferative neoplasms
    Claire Hidalgo-Curtis
    University of Southampton, UK
    Br J Haematol 148:268-73. 2010
    ..We conclude that PDGFRB fuses to diverse partner genes in atypical myeloproliferative neoplasms (MPNs). Although very rare, identification of these fusions is critical for proper management of affected individuals...
  85. ncbi Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors
    Nathalie A Lokker
    Millennium Pharmaceuticals, Inc, South San Francisco, California 94080, USA
    Cancer Res 62:3729-35. 2002
    ..family consists of four members, PDGF-A, -B, -C, and -D, that signal through the alpha and beta PDGF receptor (PDGFR) tyrosine kinases...
  86. ncbi Distribution of fibroblast growth factors (FGFR-1 and -3) and platelet-derived growth factor receptors (PDGFR) in the rat mandibular condyle during growth
    V Visnapuu
    Institute of Dentistry, University of Turku, Lemminkaisenkatu 2, FIN 20520 Turku, Finland
    Orthod Craniofac Res 5:147-53. 2002
    To elucidate the role of the fibroblast growth factors 1 and 3 (FGFR-1, -3) and the platelet derived growth factor (PDGFR) in the growth of the mandibular condylar cartilage in the rat.
  87. ncbi Platelet-derived growth factor (PDGF) receptor-alpha-activated c-Jun NH2-terminal kinase-1 is critical for PDGF-induced p21WAF1/CIP1 promoter activity independent of p53
    Jiuhong Yu
    Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Biol Chem 278:49582-8. 2003
    ..PDGF BB activates alpha- and beta-receptor subunits (alpha-PDGFR and beta-PDGFR) and induces phenotypic transformation in NIH 3T3 cells, whereas PDGF AA activates alpha-PDGFR only ..
  88. ncbi Better-surviving liver grafts by the injection of anti-CD2 antibody: the important roles of host CD8+ and CD2+CD28+ T cells in chronic graft rejection and beta type platelet-derived growth factor receptor (PDGFR-beta) expression on apoptotic liver grafts
    T Nakatsuji
    Department of Transfusion, Hamamatsu University School of Medicine, Japan
    Tohoku J Exp Med 187:215-25. 1999
    ..the graft survival, anti-CD2 monoclonal antibody (MAb) or anti beta type platelet-derived growth factor receptor (PDGFR-beta) antibody (Ab) was injected, or splenectomy was performed in the rats which were then followed until 10 to 11 ..
  89. ncbi The use of immunohistochemistry in distinguishing reactive from neoplastic mesothelium. A novel use for desmin and comparative evaluation with epithelial membrane antigen, p53, platelet-derived growth factor-receptor, P-glycoprotein and Bcl-2
    R L Attanoos
    Department of Histopathology, Llandough Hospital, Cardiff and Vale NHS Trust, Penarth, Cardiff, Wales, UK
    Histopathology 43:231-8. 2003
    ....
  90. pmc Phosphotyrosine binding domain-dependent upregulation of the platelet-derived growth factor receptor alpha signaling cascade by transforming mutants of Cbl: implications for Cbl's function and oncogenicity
    D P Bonita
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 17:4597-610. 1997
    ..We identified platelet-derived growth factor receptor alpha (PDGFR alpha) as one target of mutant Cbl-induced deregulation...
  91. ncbi Time- and cell type-specific induction of platelet-derived growth factor receptor-beta during cerebral ischemia
    Oliver Renner
    Department of Experimental Cardiology, Max Planck Institute for Physiological and Clinical Research, D 61231 Bad Nauheim, Germany
    Brain Res Mol Brain Res 113:44-51. 2003
    ..The platelet-derived growth factor (PDGF)-B/PDGF receptor (PDGFR)-beta system, hitherto thought to contribute mainly to neuroprotection, may also support angiogenesis and vascular ..
  92. doi Platelet-derived growth factor isoform expression in carbon tetrachloride-induced chronic liver injury
    Erawan Borkham-Kamphorst
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital Aachen, Aachen, Germany
    Lab Invest 88:1090-100. 2008
    ..Induction of PDGF receptor type-beta (PDGFR beta) in HSC is well documented in single-dose carbon tetrachloride (CCl(4))-induced acute liver injury...
  93. ncbi Identification and distribution of a novel platelet-derived growth factor receptor beta variant: effect of retinoic acid and involvement in cell differentiation
    Yan Wang
    Department of Biochemistry and Molecular and Cellular Biology, Georgetown University Medical Center, Washington, D C 20057, USA
    Endocrinology 148:2233-50. 2007
    We have shown previously that neonatal testicular gonocytes express platelet-derived growth factor receptors (PDGFR) alpha and beta...
  94. ncbi Expression of platelet-derived growth factor (PDGF) in the epididymis and analysis of the epididymal development in PDGF-A, PDGF-B, and PDGF receptor beta deficient mice
    Sabrina Basciani
    Department of Medical Pathophysiology, University of Rome La Sapienza, Policlinico Umberto I, 00161 Rome, Italy
    Biol Reprod 70:168-77. 2004
    ..kidney prompted us to investigate the immunohistochemical localization of PDGF A- and B-chain and PDGF receptor (PDGFR) alpha- and beta-subunit in rat and mouse epididymis, the expression profiles of the corresponding mRNAs, and the ..
  95. ncbi [Expression and gene mutation of phospho-platelet derived growth factor receptor alpha and C-kit in gastrointestinal and extra-gastrointestinal stromal tumors]
    Mi Tang
    Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha 410011, China
    Zhonghua Wei Chang Wai Ke Za Zhi 11:80-3. 2008
    To investigate the expression of phospho-platelet derived growth factor receptor alpha (P-PDGFR-alpha) in gastrointestinal stromal tumors (GIST) and extra-gastrointestinal stromal tumors (EGIST) and its clinical significance.
  96. doi Sorafenib: a review of its use in advanced hepatocellular carcinoma
    Gillian M Keating
    Wolters Kluwer Health mid R Adis, Auckland, New Zealand
    Drugs 69:223-40. 2009
    ....
  97. pmc Effect of platelet-derived growth factor receptor-beta inhibition with STI571 on radioimmunotherapy
    Janina Baranowska-Kortylewicz
    Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, Nebraska 68198 6850, USA
    Cancer Res 65:7824-31. 2005
    ..A combination of the tumor stroma-reactive STI571, a potent platelet-derived growth factor receptor-beta (PDGFr-beta) antagonist, and the tumor-seeking radiolabeled antibody B72...
  98. ncbi Emerging role of platelet-derived growth factor receptor-beta inhibition in radioimmunotherapy of experimental pancreatic cancer
    Janina Baranowska-Kortylewicz
    Department of Radiation Oncology, J Bruce Henriksen Cancer Research Laboratories, University of Nebraska Medical Center, Omaha, Nebraska 68198 6850, USA
    Clin Cancer Res 13:299-306. 2007
    ..The purpose of reported here studies was to implement a multimodality approach to radioimmunotherapy of pancreatic cancer and, ultimately, to develop a course of therapy with the clinical value...
  99. ncbi Developmental distribution of platelet-derived growth factor in the mouse central nervous system
    J B Hutchins
    Department of Anatomy, University of Mississippi Medical Center, Jackson 39216 4505
    Brain Res Dev Brain Res 67:121-35. 1992
    ..By E15, both PDGF isoform and PDGF receptor beta subunit immunoreactivity have declined to near-background levels in the sensory ganglia, while in the spinal cord and developing forebrain, levels of all PDGF-related proteins remain high...
  100. ncbi Effects of ribozyme targeting platelet-derived growth factor receptor beta subunit gene on the proliferation and apoptosis of hepatic stellate cells in vitro
    Yue Xiang Chen
    Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
    Chin Med J (Engl) 118:982-8. 2005
    ..potent growth factor for HSC is platelet-derived growth factor receptor (PDGF) and PDGF receptor beta subunit (PDGFR-beta) is the predominant signal transduction pathway of PDGF which is overexpressed in activated HSC...
  101. doi Post-transcriptional regulation of osteoblastic platelet-derived growth factor receptor-alpha expression by co-cultured primary endothelial cells
    Gunter Finkenzeller
    Department of Plastic and Hand Surgery, University of Freiburg Medical Center, Freiburg, Germany
    Cells Tissues Organs 192:28-38. 2010
    Platelet-derived growth factor receptor (PDGFR) signaling plays an important role in osteoblast function. Inhibition of PDGFR activity leads to a suppression of osteoblast proliferation, whereas mineralized matrix production is enhanced...

Research Grants64

  1. The Role of White Matter Progenitors in Glioma Formation and Progression
    Peter D Canoll; Fiscal Year: 2013
    ..population of oligodendrocyte progenitor cells that express platelet derived growth factor receptor alpha (PDGFR1). Normally these cells are non-migratory and slowly proliferating...
  2. Anti-Fibrotic Therapy for Scleroderma/SSc
    Latha Paka; Fiscal Year: 2010
    ..Increased expression of both platelet derived growth factor (PDGF) and its receptors (PDGFR1 and PDGFR2) have been demonstrated in skin of scleroderma patients...
  3. INFLAMMATORY MEDIATORS AND GLOMERULAR CELLS IN CULTURE
    Hanna Abboud; Fiscal Year: 2007
    ..This will be accomplished by generation of chimeric embryos expressing the mutant PDGFRb using MC- specific promoter and studying MC phenotype in these embryos. ..
  4. Role of JAK2V617F in the Pathogenesis of Myeloproliferative Disorders.
    Golam Mohi; Fiscal Year: 2013
    ..The results of these studies may identify new therapeutic targets for MPDs. Moreover, our inducible JAK2V617F knock-in mouse will provide a unique and reproducible animal model to test novel therapies for JAK2V617F-associated MPDs. ..
  5. Role of O2 in PDGFRb expression and function in aging.
    Wende Reenstra; Fiscal Year: 2007
    ..Findings from these studies will have important implications for novel therapeutic approaches in aging. [unreadable] [unreadable] [unreadable]..
  6. Molecular Mechanisms of Heart Regeneration
    CHING LING ELLEN LIEN; Fiscal Year: 2013
    ..We further propose to determine the function of PDGFR1 signaling in zebrafish cardiomyocytes and cardiac progenitors (Aim 3)...
  7. Role of Platelet derived growth factor receptor-a in Liver Patho-biology
    SATDARSHAN SINGH MONGA; Fiscal Year: 2013
    ..the role of a lesser known molecule in hepatocyte biology, platelet derived growth factor receptor-alpha (PDGFR[unreadable]) based on some intriguing observations made over last several years...
  8. PDGF-Receptor regulation in Cocaine and Tat mediated Smooth Muscle Hyperplasia
    Navneet Kaur Dhillon; Fiscal Year: 2012
    ..the cellular and molecular mechanism(s) involved in the regulation of expression and activation of PDGF-receptors (PDGFR) in the HIV-1 protein Tat and cocaine exposed human pSMCs...
  9. ELUCIDATING THE FUNCTION OF MATRIPTASE-ACTIVATED PDGF D IN BONE METASTATIC PROSTA
    ABDO JAMAL NAJY; Fiscal Year: 2012
    ..We believe our findings will contribute greatly toward understanding the role of the PDGF-PDGFR axis in prostate cancer metastasis...
  10. Ovarian hormone suppression and regulation of adipogenesis in women
    Wendy M Kohrt; Fiscal Year: 2012
    ..bone marrow progenitor (BMP) cells using cell surface markers (Notch 4, Platelet-derived Growth Factor Receptor (PDGFR) 2, Integrin 15, CD36) that enable detection by flow cytometry...
  11. PKD Family Kinase Function and Signaling in Lung Fibroblasts
    Hua Tang; Fiscal Year: 2012
    ..suppressed both mRNA and protein levels of profibrotic platelet-derived growth factor receptor-[unreadable] (PDGFR[unreadable]) in the fibroblasts...
  12. Cadherin-11 growth factor receptor interactions in RA fibroblast hyperplasia
    ERIKA HEIDI NOSS; Fiscal Year: 2013
    ..in vitro studies using human RA synovial fibroblasts to define the signaling pathways downstream of cad11 and PDGFR that promote synovial fibroblast proliferation and survival...
  13. PDGFR and KDR Inhibitors for Liver Fibrosis
    Bert Oehlen; Fiscal Year: 2010
    ..Angion has identified a small molecule, ANG-3154, that inhibits activation of the PDGF receptor (PDGFR-b) and the (KDR) and their tyrosine kinase activities...
  14. PDGF D AND PROSTATE CANCER BONE METASTASIS
    Hyeong Reh Choi Kim; Fiscal Year: 2013
    ..Increasing evidence indicate the significance of PDGF receptor signaling, especially 2-PDGFR, in prostate cancer progression and bone metastasis...
  15. Mechanism of Renal Cell Injury
    Goutam Ghosh Choudhury; Fiscal Year: 2013
    ..in human and experimental model is increased expression of platelet-derived growth factor receptor-2 (PDGFR) in mesangial cells with concomitant proliferation and migration...
  16. A PDGFR inhibitor for the treatment of pulmonary arterial hypertension
    Lawrence S Zisman; Fiscal Year: 2010
    ..The purpose of this proposal is to develop a novel highly selective platelet derived growth factor receptor (PDGFR) inhibitor for PAH that will be delivered by inhalation...
  17. Analysis of PDFR alpha signaling in cardiac fibroblast development and function
    Christopher L Smith; Fiscal Year: 2012
    ..Platelet derived growth factor receptors (PDGFR) are receptor tyrosine kinases that provide signals important for fibroblast migration and proliferation, and are ..
  18. Transcriptional Targets of PDGF Signaling during Craniofacial Development
    Harish Vasudevan; Fiscal Year: 2013
    ..In mice, loss of PDGF Receptor [unreadable] (PDGFR[unreadable]) or its ligands, PDGFA and PDGFC, results in facial clefting...
  19. Characterizing the mechanisms of PDGFRalpha regulation in upper lip development
    Fenglei He; Fiscal Year: 2013
    ..Mutations of Platelet Derived Growth Factor Receptor [unreadable] (PDGFR[unreadable]) signaling have been tightly linked to cleft lip/palate in humans and mice, suggesting an ..
  20. Molecular and Functional Mechanisms of Purinergic Relaxation in Detrusor Muscle
    Sang Don Koh; Fiscal Year: 2013
    ..interstitial cells are identified using antibodies aainst platelet-derived growth factor receptor-[unreadable] (PDGFR-[unreadable]+)...
  21. Therapeutic Targets in Alveolar Rhabdomyosarcoma
    Charles Keller; Fiscal Year: 2012
    ..amongst patients enrolled in a national clinical trial suggest that the platelet-derived growth factor receptor A (PDGFR-A) may be a mediator of disease progression and metastasis...
  22. An inhaled PDGF receptor inhibitor for the treatment of pulmonary arterial hyper
    Lawrence S Zisman; Fiscal Year: 2013
    ..for pulmonary arterial hypertension (PAH) consisting of the inhaled platelet derived growth factor receptor (PDGFR) inhibitor PK10453. PAH is a disease of the pulmonary vasculature associated with high morbidity and mortality...
  23. Identification and regulation of quiescent stemcells in the adult brain
    ANGEL RICARDO MALDONADO; Fiscal Year: 2013
    ..Here we propose that platelet-derived growth factor receptor beta (PDGFR[unreadable]) is one such marker...
  24. PDGF Receptor Signaling in Mammalian Development
    Michelle D Tallquist; Fiscal Year: 2012
    ..mechanism of PDGF receptor action in the initial development of the epicardium;2) To elucidate the requirement for PDGFR[unreadable] in coronary vascular smooth muscle cells and cardiac fibroblasts;and 3) To determine if PDGFR[..
  25. Analysis of the Novel Kinase ROR2: A New Molecular Target in Renal Cell Carcinoma
    Tricia M Wright; Fiscal Year: 2010
    ..b>PDGFR and VEGFR are found on tumor associating pericytes and endothelial cells respectively, but not on the tumor cells ..
  26. Modulation of Glioma Growth and Invasion by HCMV Glycoprotein B
    Liliana Soroceanu; Fiscal Year: 2010
    ..We have also discovered that HCMV activates robust PDGFR1 signaling in GBM cells, and that PDGFR1 activation is actually required for HCMV infection...
  27. Cervical spinal injury and demyelination in aged rats
    Michael S Beattie; Fiscal Year: 2010
    ..adult glial progenitor cells of the oligodendrocyte lineage, which are characterized by the expression of the PDGFR1 and the proteoglycan NG2 (see Horner et al, 2002;Polito and Reynolds, 2006;Rhodes et al, 2006). In Aim 1...
  28. Defining mechanisms of MEK1/2 inhibitor response in triple negative breast cancer
    Martin Whittle; Fiscal Year: 2013
    ..abstract_text> ..
  29. The Role of PDGFR in Medulloblastoma Progression
    Tobey J Macdonald; Fiscal Year: 2010
    ..We hypothesize that )latelet-derived growth factor (PDGFR)-mediated signal transduction enhances tumor cell responses that promote the growth and metastatic spread of ..
  30. Cytomegalovirus Gene Expression and Strain Variability in Glioma Pathogenesis
    Liliana Soroceanu; Fiscal Year: 2013
    ..al. Can Res, 2008) and that activation of PDGFR1, a growth factor receptor implicated in gliomagenesis, is required for infection (Soroceanu et al., Nature, 2008)...
  31. Diagnosing Emergence of Kinase Inhibitor Resistance on a Microchip
    Thomas G Graeber; Fiscal Year: 2013
    ..Namely, the platform will monitor pERK, PDGFR[unreadable], pAKT and the apoptosis reporter cleaved Caspase-3/7 using fine needle aspirate (FNA) biopsies...
  32. HEMANGIOBLAST DEVELOPMENT AND REGULATION
    Kyunghee Choi; Fiscal Year: 2013
    ..We recently made progress in further identifying Flk-1+ hemangiogenic and cardiogenic mesoderm by the PDGFR1 expression...
  33. SIGNALING PATHWAYS REGULATING EPITHELIAL CELL SURVIVAL
    Paul Dent; Fiscal Year: 2013
    ..abstract_text> ..
  34. Prospective Purification of Adult Stem Cell Astrocytes
    Fiona Doetsch; Fiscal Year: 2013
    ..Together these studies will yield key insights into the regulation of stem cell quiescence in the adult brain. ..
  35. IMMUNOGENETICS OF ANTIBODY INDUCED NEPHRITIS
    Chandra Mohan; Fiscal Year: 2012
    ..Collectively, these studies are likely to shed novel light on the genetic and molecular origins of antibody-mediated nephritis. ..
  36. Improved therapeutic approaches for hematological disorder treated with tyrosine
    Mohammad Azam; Fiscal Year: 2013
    ..We anticipate that a detail characterization of this hydrophobic-motif will help us in developing new allosteric inhibitors tha can be used in combination with ATP- competitive inhibitors to suppress all forms resistant mutations. ..
  37. NG2-PG in tumor vascularization and progression
    William B Stallcup; Fiscal Year: 2013
    ....
  38. PDGF and PVR
    Andrius Kazlauskas; Fiscal Year: 2012
    ..Growth factors outside of the PDGF family (non-PDGFs) indirectly activated PDGFR1 by a reactive oxygen species (ROS)-dependent mechanism that we are calling "transactivation"...
  39. Caveolae structure and function
    RICHARD G ANDERSON; Fiscal Year: 2010
    ..A better understanding of basic caveolae biology may lead to new strategies for treating human disease. ..
  40. Phase II Clinical Trial of AZD2171 Monotherapy In Recurrent Head and Neck Cancer
    James Rocco; Fiscal Year: 2007
    ..antiangiogenic effects of AZD2171 and identify potential surrogate markers of response AIM 3: Identify differentially expressed genes that correlate with HNSCC tumor response during AZD2171 therapy [unreadable] [unreadable] [unreadable]..
  41. Smooth Muscle Cell Protein Serotonylation and Pulmonary Hypertension
    BARRY FANBURG; Fiscal Year: 2013
    ..induced SMC proliferation and migration;3) assess modification of SMC protein/FN serotonylation by hypoxia, PDGF/PDGFR and BMP/BMPR, known participants in PH;and 4) examine the association of lung and pulmonary artery protein/FN ..
  42. Mac-1 coordinates PDGF-CC activation by microglia and promotes BBB opening
    Li Zhang; Fiscal Year: 2013
    ..on the generation of active forms of PDGF-CC in the brain, which in turn activate the PDGF receptor-[unreadable] (PDGFR[unreadable]) on perivascular astrocytes (Su, et al, Nat Med, 2008)...
  43. Serotonin and the Rho Signaling Pathway in Smooth Muscle Cells
    BARRY FANBURG; Fiscal Year: 2010
    ..We hypothesize that activation of the Rho pathway and transactivation of PDGFR participate in SMC proliferative and migratory processes important in development of PH...
  44. GANGLIOSIDES AS BIOMODULATORS OF THE ALPHA PDGF RECEPTOR
    Allan Yates; Fiscal Year: 1999
    ..determined that specific gangliosides (GM-1) inhibit ligand induced dimerization and tyrosine phosphorylation of PDGFR. Results of these studies clearly demonstrated that gangliosides play a regulatory role in several platelet ..
  45. Experimental models of scleroderma pathogenesis
    Francesco Ramirez; Fiscal Year: 2009
    ..We base this application on exciting new evidence that circulating auto-antibodies against the PDGF receptor (PDGFR) are causally associated with the pro-fibrotic phenotype of SSc fibroblasts...
  46. PDGF Receptor Regulation by CBL
    Hamid Band; Fiscal Year: 2007
    ..is linked to cell proliferation; invasiveness and angiogenesis in human cancers, in particular glial tumors, and PDGFR fusion oncogenes are responsible for a subset of myelogenous leukemia...
  47. Pilot Testing of VEGF/PDGF inhibitors for chemoprevention of bone metastasis
    Hyeong Reh Kim; Fiscal Year: 2007
    ..Studies suggest that platelet- derived growth factor receptor-beta (beta-PDGFR) signaling promotes prostate bone metastasis via its regulation of osteoprogenitor cell migration, proliferation ..
  48. Small Molecule Kinase Inhibitor for Malignant Glioma
    Charles Stiles; Fiscal Year: 2004
    ..in the initial clinical trial with a signal transduction inhibitor, the platelet-derived growth factor receptor (PDGFR)/abl blocker STI571 (Gleevec), in gliomas...
  49. COMBINATION GROWTH FACTOR ANTAGONIST/CHEMOTHERAPY IN PCA
    Yoo Joung Ko; Fiscal Year: 2004
    ..There is emerging evidence that certain RTKs, specifically platelet derived growth factor receptor (PDGFr) and epidermal growth factor receptor (EGFr) have a role in the growth advanced hormone independent prostate ..
  50. INTERACTION OF PDGF AND INTEGRINS IN THE HEART
    Louis Terracio; Fiscal Year: 2002
    ..The proposed investigations will address the hypothesis that Platelet Derived Growth Factor receptor (PDGFr) subtypes are differentially expressed on myocytes and fibroblasts and when stimulated by the different isoforms ..
  51. Anti-Fibrotic Therapy for Scleroderma/SSc
    Latha Paka; Fiscal Year: 2013
    ..Increased expression of both platelet derived growth factor (PDGF) and its receptors (PDGFR? and PDGFR?) have been demonstrated in skin of scleroderma patients...
  52. PI3K/Akt-mediated PDGFRalpha signaling in craniofacial development
    KATHERINE ANN FANTAUZZO; Fiscal Year: 2013
    ..Previous work by the Soriano laboratory has identified PI3K as the main downstream effector of PDGFR[unreadable] signaling during craniofacial development in the mouse, however, further downstream pathways are ..
  53. Mechanistic studies of fibronectin peptide P12: a co-factor of PDGF-BB
    RICHARD AUGUST CLARK; Fiscal Year: 2013
    ..b>PDGFR effectors upstream and downstream PI3K-Akt pathway will be probed by western blot to determine the effectors of ..
  54. Antifibrotic Therapy for Chronic Kidney Disease
    Prakash Narayan; Fiscal Year: 2013
    ..and in vitro biology, Angion Biomedica has synthesized a highly water soluble, orally bioavailable, small molecule PDGFR+KDR inhibitor, ANG3070...
  55. PDGF Regulation of Cell Growth and Death
    Hyeong Reh Kim; Fiscal Year: 2006
    ..PDGF exerts its cellular effects by activating two structurally related cell surface receptor tyrosine kinases (a-PDGFR and beta-PDGFR)...
  56. Desensitization of Vascular Receptor Tyrosine Kinases
    Neil Freedman; Fiscal Year: 2009
    ..Therapeutic implications for cardiovascular diseases may derive from determining how GRKs regulate RPTK signaling, and which RPTKs are subject to GRK-mediated regulation. ..
  57. High Throughput Transcriptome Sequencing for Systematic Detection of Recurrent Tr
    Chandan Kumar; Fiscal Year: 2012
    ..prognostic markers and therapeutic targets such as the BCR-ABL1 gene fusion in Chronic Myeloid Leukemia, PDGFR mutation in gastrointestinal stromal tumors, ERBB2 amplification in breast cancers, and EGFR mutations in lung ..
  58. Targeting beta-catenin in liver pathology: Novel Interactions, Novel Paradigms
    SATDARSHAN SINGH MONGA; Fiscal Year: 2013
    ..In aim 2 we will investigate mechanism and biological implications of PDGFR[unreadable] upregulation and activation after [unreadable]-catenin inhibition in HCC cells...
  59. Treatment of a Complex Retinal Degenerative Syndrome
    Val C Sheffield; Fiscal Year: 2013
    ..pathways including apoptosis;endoplasmic reticulum (ER) stress and the unfolded protein response;chaperones;and PDGFR[unreadable] signaling...
  60. A Mouse Model for Human Gastrointestinal Stromal Tumor
    Peter Besmer; Fiscal Year: 2013
    ..for the pathogenesis of GIST are thought to be gain-of-function mutations in the KIT gene or occasionally in the PDGFR alpha gene. Patients with familial GIST syndrome carry a germline KIT gain-of-function mutation...
  61. Brain Pericyte and Amyloid-beta Peptide Interaction
    Donghui Zhu; Fiscal Year: 2013
    ..Aim 1 is to determine if A[unreadable] decreases PDGFR[unreadable] and signaling molecules involved in pericyte-mediated BBB integrity regulation, leading to a ..
  62. Apoptosome Regulation in Leukemia by Protein Phosphatase 5 Hypoacetylation
    KRISTEN FOSS; Fiscal Year: 2013
    ..S alone. Tumorigenesis in leukemia is often driven by constitutively active tyrosine kinases (e.g. Bcr-Abl, Tel-PDGFR, mutant Flt3), and much effort has been directed towards the development of agents that therapeutically inhibit ..
  63. Mutations in Smooth Muscle Contractile Proteins: Pathways to Vascular Diseases
    Dianna M Milewicz; Fiscal Year: 2013
    ..arteries, specifically increased SMC proliferation as a consequence of altered focal adhesions and activation of PDGFR-Beta receptors in response to abnormal cellular force generation. To test these hypotheses...
  64. PHOSPHORYLATION IN RENAL CELL INJURY
    Goutam Ghosh Choudhury; Fiscal Year: 2004
    DESCRIPTION (Adapted from the Applicant's Abstract): Platelet-derived growth factor receptor b (PDGFR) is expressed in injured glomeruli and in activated cultured mesangial cells...