PDGFB

Summary

Gene Symbol: PDGFB
Description: platelet derived growth factor subunit B
Alias: IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis, platelet-derived growth factor subunit B, PDGF subunit B, PDGF, B chain, becaplermin, platelet-derived growth factor 2, platelet-derived growth factor B chain, platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog), platelet-derived growth factor, beta polypeptide (oncogene SIS), proto-oncogene c-Sis
Species: human

Top Publications

  1. pmc Neuropilin-1 promotes cirrhosis of the rodent and human liver by enhancing PDGF/TGF-beta signaling in hepatic stellate cells
    Sheng Cao
    Gastroenterology Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Invest 120:2379-94. 2010
  2. pmc Hypoxia-inducible factor-1 α/platelet derived growth factor axis in HIV-associated pulmonary vascular remodeling
    Joel Mermis
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Kansas Medical Center, Kansas City, USA
    Respir Res 12:103. 2011
  3. pmc Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells
    Ian M Evans
    UCL Division of Medicine, 5 University Street, London WC1E 6JJ, United Kingdom
    Mol Cell Biol 31:1174-85. 2011
  4. pmc Interleukin-18/WNT1-inducible signaling pathway protein-1 signaling mediates human saphenous vein smooth muscle cell proliferation
    Venkatapuram Seenu Reddy
    Cardiothoracic Surgery, University of Texas Health Science Center, San Antonio, Texas
    J Cell Physiol 226:3303-15. 2011
  5. pmc A growth factor attenuates HIV-1 Tat and morphine induced damage to human neurons: implication in HIV/AIDS-drug abuse cases
    Shaily Malik
    Cellular and Molecular Neuroscience, National Brain Research Center, Manesar, Gurgaon, Haryana, India
    PLoS ONE 6:e18116. 2011
  6. doi Impact of resistance exercise training on interleukin-6 and JAK/STAT in young men
    Marissa K Trenerry
    Molecular Nutrition Unit, School of Exercise and Nutrition Science, Deakin University, 221 Burwood Highway, Burwood, Victoria 3125, Australia
    Muscle Nerve 43:385-92. 2011
  7. pmc Neuraminidase-1, a subunit of the cell surface elastin receptor, desialylates and functionally inactivates adjacent receptors interacting with the mitogenic growth factors PDGF-BB and IGF-2
    Aleksander Hinek
    Department of Laboratory Medicine and Pathobiology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
    Am J Pathol 173:1042-56. 2008
  8. pmc Endothelial cell hyperplasia in human glioblastoma: coexpression of mRNA for platelet-derived growth factor (PDGF) B chain and PDGF receptor suggests autocrine growth stimulation
    M Hermansson
    Ludwig Institute for Cancer Research, Uppsala Branch, University Hospital, Sweden
    Proc Natl Acad Sci U S A 85:7748-52. 1988
  9. ncbi The dermatofibrosarcoma protuberans-associated collagen type Ialpha1/platelet-derived growth factor (PDGF) B-chain fusion gene generates a transforming protein that is processed to functional PDGF-BB
    A Shimizu
    Ludwig Institute for Cancer Research, Uppsala, Sweden
    Cancer Res 59:3719-23. 1999
  10. ncbi PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor
    X Li
    Ludwig Institute for Cancer Research, Stockholm, Sweden
    Nat Cell Biol 2:302-9. 2000

Research Grants

  1. Role of Acetaldehyde on PDGF-BB-induced HSC Migration and Proliferation.
    Raj M Lakshman; Fiscal Year: 2011
  2. ANALYSIS OF THE RECEPTOR FOR C-SIS PROTEIN
    Subal Bishayee; Fiscal Year: 1991
  3. Wei Zhang; Fiscal Year: 2014
  4. Dissecting Glioma Genesis through a Glial-Specific Mouse Model
    Wei Zhang; Fiscal Year: 2009
  5. Shilpa J Buch; Fiscal Year: 2016
  6. Infection-Prevention Barriers for Osseointegrated Percutaneous Implants
    David W Grainger; Fiscal Year: 2012
  7. MOLECULAR STUDIES OF TRANSFORMING GROWTH FACTORS
    Daniel Donoghue; Fiscal Year: 2001
  8. Acquired Resistance to VEGF blockade in Wilms tumor
    Jessica Kandel; Fiscal Year: 2007
  9. TROPHOBLAST PROLIFERATION AND GROWTH FACTOR EXPRESSION
    Robert Taylor; Fiscal Year: 1991
  10. PDGF-MEDIATED GENE TRANSFER & PERIODONTAL WOUND HEALING
    William Giannobile; Fiscal Year: 2001

Patents

  1. MULTICISTRONIC EXPRESSION UNITS AND THEIR USE
  2. PRODUCTION OF HETERODIMER PDGF-AB BY MEANS OF A BICISTRONIC VECTOR SYSTEM IN MAMMALIAN CELLS

Detail Information

Publications263 found, 100 shown here

  1. pmc Neuropilin-1 promotes cirrhosis of the rodent and human liver by enhancing PDGF/TGF-beta signaling in hepatic stellate cells
    Sheng Cao
    Gastroenterology Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Invest 120:2379-94. 2010
    ....
  2. pmc Hypoxia-inducible factor-1 α/platelet derived growth factor axis in HIV-associated pulmonary vascular remodeling
    Joel Mermis
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Kansas Medical Center, Kansas City, USA
    Respir Res 12:103. 2011
    ..In this study, we explored the impact of HIV protein induced oxidative stress on production of hypoxia inducible factor (HIF)-1α and platelet-derived growth factor (PDGF), critical mediators implicated in the pathogenesis of HIV-PAH...
  3. pmc Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells
    Ian M Evans
    UCL Division of Medicine, 5 University Street, London WC1E 6JJ, United Kingdom
    Mol Cell Biol 31:1174-85. 2011
    ....
  4. pmc Interleukin-18/WNT1-inducible signaling pathway protein-1 signaling mediates human saphenous vein smooth muscle cell proliferation
    Venkatapuram Seenu Reddy
    Cardiothoracic Surgery, University of Texas Health Science Center, San Antonio, Texas
    J Cell Physiol 226:3303-15. 2011
    ....
  5. pmc A growth factor attenuates HIV-1 Tat and morphine induced damage to human neurons: implication in HIV/AIDS-drug abuse cases
    Shaily Malik
    Cellular and Molecular Neuroscience, National Brain Research Center, Manesar, Gurgaon, Haryana, India
    PLoS ONE 6:e18116. 2011
    ..We have also showed for the first time that PDGF-BB can protect against simultaneous exposure of Tat and morphine, strengthening its role as a neuroprotective agent that could be considered for therapeutic intervention...
  6. doi Impact of resistance exercise training on interleukin-6 and JAK/STAT in young men
    Marissa K Trenerry
    Molecular Nutrition Unit, School of Exercise and Nutrition Science, Deakin University, 221 Burwood Highway, Burwood, Victoria 3125, Australia
    Muscle Nerve 43:385-92. 2011
    ..These responses are preserved after intense exercise. This suggests they are not modified by training and may be an essential component of the adaptive responses to intense exercise...
  7. pmc Neuraminidase-1, a subunit of the cell surface elastin receptor, desialylates and functionally inactivates adjacent receptors interacting with the mitogenic growth factors PDGF-BB and IGF-2
    Aleksander Hinek
    Department of Laboratory Medicine and Pathobiology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
    Am J Pathol 173:1042-56. 2008
    ..Furthermore, we provide direct evidence that neuraminidase caused the desialylation of both PDGF and IGF-1 receptors and diminished the intracellular signals induced by the mitogenic ligands PDGF-BB and IGF-2...
  8. pmc Endothelial cell hyperplasia in human glioblastoma: coexpression of mRNA for platelet-derived growth factor (PDGF) B chain and PDGF receptor suggests autocrine growth stimulation
    M Hermansson
    Ludwig Institute for Cancer Research, Uppsala Branch, University Hospital, Sweden
    Proc Natl Acad Sci U S A 85:7748-52. 1988
    The genes for platelet-derived growth factor (PDGF) A chain, B chain/c-sis, and the PDGF receptor are expressed in human malignant glioma cell lines...
  9. ncbi The dermatofibrosarcoma protuberans-associated collagen type Ialpha1/platelet-derived growth factor (PDGF) B-chain fusion gene generates a transforming protein that is processed to functional PDGF-BB
    A Shimizu
    Ludwig Institute for Cancer Research, Uppsala, Sweden
    Cancer Res 59:3719-23. 1999
    ..and 22, which fuse the collagen type Ialpha1 (COLIA1) gene to the platelet-derived growth factor (PDGF) B-chain (PDGFB) gene...
  10. ncbi PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor
    X Li
    Ludwig Institute for Cancer Research, Stockholm, Sweden
    Nat Cell Biol 2:302-9. 2000
    ....
  11. ncbi PDGF-D, a new protease-activated growth factor
    W J LaRochelle
    CuraGen Corporation, 555 Long Wharf Drive, New Haven, Connecticut 06511, USA
    Nat Cell Biol 3:517-21. 2001
    ..However, in cells expressing both PDGFRs, PDGF-D activates both receptors. This indicates that PDGFR-alpha activation may result from PDGFR-alpha/beta heterodimerization...
  12. ncbi Regulation of the stepwise proteolytic cleavage and secretion of PDGF-B by the proprotein convertases
    Geraldine Siegfried
    Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, 110 Pine Ave West, Montreal, Quebec, Canada H2W 1R7
    Oncogene 24:6925-35. 2005
    ..Our findings emphasize the importance of the convertase-directed processing of proPDGF-B at the RGRR81/ sequence for PDGF-B maturation and secretion...
  13. ncbi Detection of COL1A1-PDGFB fusion transcripts and PDGFB/PDGFRB mRNA expression in dermatofibrosarcoma protuberans
    Tomonari Takahira
    The Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Mod Pathol 20:668-75. 2007
    Fusion of the collagen type I alpha 1 (COL1A1) gene with the platelet-derived growth factor beta chain (PDGFB) gene has been described in dermatofibrosarcoma protuberans...
  14. ncbi Dermatofibrosarcoma protuberans COL1A1-PDGFB fusion is identified in virtually all dermatofibrosarcoma protuberans cases when investigated by newly developed multiplex reverse transcription polymerase chain reaction and fluorescence in situ hybridization
    Kayuri U Patel
    Department of Pathology at Texas Children s Hospital and Baylor College of Medicine, Houston, TX 77030, USA
    Hum Pathol 39:184-93. 2008
    ..by a t(17;22) translocation or a supernumerary ring chromosome that results in the fusion of exon 2 of PDGFB to various exons of the COL1A1 gene...
  15. pmc Platelet-derived growth factor protects neurons against gp120-mediated toxicity
    Fuwang Peng
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Neurovirol 14:62-72. 2008
    ..Taken together these findings lead us to suggest that PDGF-BB could be considered as a therapeutic agent that can mitigate gp120-mediated neurotoxicity in HAD...
  16. pmc Mechanisms of platelet-derived growth factor-mediated neuroprotection--implications in HIV dementia
    Fuwang Peng
    Department of Molecular and Integrative Physiology, 5000 Wahl Hall East, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Eur J Neurosci 28:1255-64. 2008
    ..Furthermore, PDGF-mediated protection also involved the inhibition of gp120-induced release of mitochondrial cytochrome C. Our findings thus underscore the roles of both PI3K/Akt and Bcl family pathways in PDGF-mediated neuroprotection...
  17. doi Co-expression of PDGF-B and VEGFR-3 strongly correlates with lymph node metastasis and poor survival in non-small-cell lung cancer
    T Donnem
    Department of Oncology, Institute of Clinical Medicine, University of Tromso, Tromso, Norway
    Ann Oncol 21:223-31. 2010
    ..We aimed to study the PDGFs/PDGFRs and correlations with lymph node metastasis (LNM) and investigate the prognostic impact of the co-expression of PDGF-B and VEGFR-3 and its correlation with LNM...
  18. doi Dermatofibrosarcoma protuberans: clinical, pathological, and genetic (COL1A1-PDGFB ) study with therapeutic implications
    Beatriz Llombart
    Department of Dermatology, University of Valencia, Valencia, Spain
    Histopathology 54:860-72. 2009
    To analyse the presence of collagen type I alpha 1-platelet-derived growth factor beta (COL1A1-PDGFB) transcripts in 20 cases of dermatofibrosarcoma protuberans (DFSP) and to assess the relationship between COL1A1 breakpoints and ..
  19. pmc Clinicopathological significance of platelet-derived growth factor (PDGF)-B and vascular endothelial growth factor-A expression, PDGF receptor-β phosphorylation, and microvessel density in gastric cancer
    Shioto Suzuki
    Department of Molecular and Cellular Pathology, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
    BMC Cancer 10:659. 2010
    ....
  20. pmc Mesenchymal stem cell migration is regulated by fibronectin through α5β1-integrin-mediated activation of PDGFR-β and potentiation of growth factor signals
    Jennifer Veevers-Lowe
    Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
    J Cell Sci 124:1288-300. 2011
    ..This synergistic relationship between α5β1-integrin and PDGFR-β is a fundamental determinant of cell migration. Thus, fibronectin-rich matrices can prime PDGFR-β to recruit mesenchymal cells at sites of vascular remodelling...
  21. doi PDGF in bone formation and regeneration: new insights into a novel mechanism involving MSCs
    Arnold I Caplan
    Skeletal Research Center, Department of Biology, Case Western Reserve University, 2080 Adelbert Road, Cleveland, Ohio 44106 7080, USA
    J Orthop Res 29:1795-803. 2011
    ..This thesis explains how PDGF functions as a powerful therapeutic agent for bone formation and repair...
  22. pmc Akt- and Erk-mediated regulation of proliferation and differentiation during PDGFRβ-induced MSC self-renewal
    Borzo Gharibi
    Periodontology, Dental Institute, King s College London, London, UK
    J Cell Mol Med 16:2789-801. 2012
    ..Thus, activation of multiple intracellular cascades is required for successful and sustainable MSC self-renewal strategies...
  23. ncbi The sequential activation and repression of the human PDGF-B gene during chronic hypoxia reveals antagonistic roles for the depletion of oxygen and glucose
    E Ullerås
    Department of Animal Development and Genetics, Evolutionary Biology Centre, Uppsala University, Sweden
    Growth Factors 19:233-45. 2001
    ..We also show that a putative hypoxia response element in the PDGF-B promoter is not sufficient for hypoxic induction, although it does function as a hypoxia independent enhancer element in hepatocellular carcinoma cells...
  24. ncbi Breast cancer cells secreted platelet-derived growth factor-induced motility of vascular smooth muscle cells is mediated through neuropilin-1
    Snigdha Banerjee
    Cancer Research Unit, VA Medical Center, Kansas City, Missouri 64128, USA
    Mol Carcinog 45:871-80. 2006
    ..Moreover, we demonstrate that PDGF physically interacts with NRP-1. We propose that tumor-derived PDGF and NRP-1 of AOSMCs function as a relay system that promotes motility of vascular SMCs...
  25. doi Ets-1 mediates platelet-derived growth factor-BB-induced thrombomodulin expression in human vascular smooth muscle cells
    I Chung Lo
    Institute of Basic Medical Sciences, National Cheng Kung University College of Medicine, Tainan, Taiwan, Republic of China
    Cardiovasc Res 81:771-9. 2009
    ..In diseased vessels, VSMC expresses TM, but the mechanisms are unclear. This study examined molecular mechanisms for TM expression in VSMCs...
  26. pmc PDGF-mediated protection of SH-SY5Y cells against Tat toxin involves regulation of extracellular glutamate and intracellular calcium
    Xuhui Zhu
    Department of Molecular and Integrative Physiology, 5000 Wahl Hall East, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Toxicol Appl Pharmacol 240:286-91. 2009
    ..These findings thus underscore the role of PDGF-mediated calcium signaling and Erk phosphorylation in the protection of cells against HIV Tat toxicity...
  27. doi Chronic treatment with PDGF-BB and endothelin-1 synergistically induces vascular hyperplasia and loss of contractility in organ-cultured rat tail artery
    Taiki Kida
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Atherosclerosis 214:288-94. 2011
    ..In this study, we examined the synergistic effects of the two potent pathogenic factors, platelet-derived growth factor-BB (PDGF-BB) and endothelin-1 (ET-1) to induce vascular hyperplasia using ex vivo organ-culture system...
  28. pmc HIV-1 Tat-mediated induction of platelet-derived growth factor in astrocytes: role of early growth response gene 1
    Crystal Bethel-Brown
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Immunol 186:4119-29. 2011
    ..Because astrogliosis is linked to disease severity, understanding its regulation by PDGF-BB could aid in the development of therapeutic intervention strategies for HAND...
  29. pmc Interaction of platelet-derived growth factor with thrombospondin 1
    P J Hogg
    Centre for Thrombosis and Vascular Research, School of Pathology, University of New South Wales, Sydney, NSW 2052, Australia
    Biochem J 326:709-16. 1997
    ..Uncomplexed PDGFBB bound to PDGF receptor with an affinity 5 +/- 2 times that of PDGFBB-TSP1 complexes. These results suggest that TSP1 might assist in the targeting of PDGF to its receptor on vascular smooth-muscle cells...
  30. ncbi Caveolin-1 in mesangial cells suppresses MAP kinase activation and cell proliferation induced by bFGF and PDGF
    Yutaka Fujita
    Division of Clinical Immunology, Department of Internal Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Kidney Int 66:1794-804. 2004
    ..Mesangial cells contain many caveolae, and thus manipulation of caveolin-1 expression level might be useful to control mesangial cell proliferation, which is an important aggravating factor in many renal diseases...
  31. ncbi Platelet-derived growth factor. Structure, function and implications in normal and malignant cell growth
    B Westermark
    Department of Pathology, University Hospital, Uppsala, Sweden
    Acta Oncol 32:101-5. 1993
    ..This view is supported by our recent finding that human melanoma cells that have been stably transfected with a PDGF B-chain cDNA, elicit a stroma response when transplanted to nude mice...
  32. ncbi [Neonatal hypoxic/ischemic encephalopathy: neuropathology and plasticity]
    M Ohno
    Department of Pediatrics, Shiga University of Medical Science
    No To Hattatsu 28:118-24. 1996
    ..Our findings suggested the crucial role of PDGF-B chain in the impending brain injury, as a neuroprotecting factor. Clinical application of neurotrophic factors is not anecdotal...
  33. ncbi Platelet-derived growth factor (PDGF) receptor-alpha-activated c-Jun NH2-terminal kinase-1 is critical for PDGF-induced p21WAF1/CIP1 promoter activity independent of p53
    Jiuhong Yu
    Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Biol Chem 278:49582-8. 2003
    ..Unlike PDGF AA, PDGF B-chain (c-sis) homodimer (PDGF BB) and its viral counterpart v-sis can serve as both competent and progression factors...
  34. ncbi Oncogenes and tumor suppressor genes
    G Klein
    Department of Tumor Biology, Karolinska Institute, Stockholm, Sweden
    Acta Oncol 27:427-37. 1988
    ..normally responds to, but does not produce, the corresponding growth factor (the autocrine model, exemplified by sis)...
  35. ncbi Rapid turnover of the platelet-derived growth factor receptor in sis-transformed cells and reversal by suramin. Implications for the mechanism of autocrine transformation
    S S Huang
    E A Doisy Department of Biochemistry, St Louis University School of Medicine, Missouri 63104
    J Biol Chem 263:12608-18. 1988
    In cells transformed by either v-sis or c-sis, the majority of the newly synthesized platelet-derived growth factor (PDGF) receptors fail to reach the cell surface and are rapidly degraded...
  36. ncbi Platelet-derived growth factor receptor beta regulates migration and DNA synthesis in metanephric mesenchymal cells
    M Arar
    Department of Pediatrics, South Texas Department of Veterans Affairs Health Care System, San Antonio, Texas 78229 3900, USA
    J Biol Chem 275:9527-33. 2000
    ..PDGF B-chain also likely stimulates proliferation of mesangial cell precursors in an autocrine fashion once these cells migrate to the glomerular tuft...
  37. ncbi The v-sis oncogene product but not platelet-derived growth factor (PDGF) A homodimers activate PDGF alpha and beta receptors intracellularly and initiate cellular transformation
    B E Bejcek
    Department of Medicine, Jewish Hospital, Washington University Medical Center, St Louis, Missouri 63110
    J Biol Chem 267:3289-93. 1992
    The v-sis oncogene product p28v-sis and the platelet-derived growth factor (PDGF) B chain share 92% homology with each other and over 50% homology with the PDGF A chain...
  38. ncbi [Effect of truncated platelet-derived growth factor-alpha receptor on apoptosis and expression of c-sis mRNA of pulmonary artery smooth muscle cells]
    Han Min Liu
    Department of Pediatrics, The West China Second Hospital, Sichuan University, Chengdu 610041, China
    Zhonghua Er Ke Za Zhi 41:329-33. 2003
    ..The study aimed to investigate the effect of truncated PDGF-alpha receptor on apoptosis and expression of c-sis mRNA of pulmonary artery smooth muscle cells (VSMCs).
  39. pmc Oncogene expression in vivo by ovarian adenocarcinomas and mixed-mullerian tumors
    B M Kacinski
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06510
    Yale J Biol Med 62:379-92. 1989
    ..tumors, a rather different pattern of oncogene expression was observed, characterized primarily by expression of sis (PDGF-B chain)...
  40. ncbi Platelet-derived growth factor-B/v-sis confers a tumorigenic and metastatic phenotype to human T98G glioblastoma cells
    O Potapova
    Sidney Kimmel Cancer Center, San Diego, California 92121, USA
    Cancer Res 56:280-6. 1996
    ..that these cells express predominantly PDGF-beta type receptors and continuously secrete small amount of PDGF-B/c-sis. Addition of suramin or specific anti-PDGF-B/v-sis antibody inhibits proliferation in culture...
  41. ncbi [MELAS without ragged-red fibers: a case report]
    N Mimaki
    Department of Pediatrics, South Kurashiki Hospital, Okayama
    No To Hattatsu 23:606-11. 1991
    ..Thus, we conclude that a simple method of identifying the strongly SDH-reactive blood vessels (SSV) in frozen sections is critical in supporting or making diagnosis of MELAS.
  42. ncbi [Experimental study of repairing full-thickness articular cartilage defect with chondrocyte-sodium alginate hydrogel-SIS complex]
    Xiangtao Mo
    Division of Stem Cell and Tissue Engineering, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu Sichuan 610041, PR China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 23:974-9. 2009
    To explore the effect of tissue engineered cartilage reconstructed by using sodium alginate hydrogel and SIS complex as scaffold material and chondrocyte as seed cell on the repair of full-thickness articular cartilage defects.
  43. ncbi Dermatofibrosarcoma protuberans of the vulva and groin: detection of COL1A1-PDGFB fusion transcripts by RT-PCR
    Neriman Gokden
    Lauren V Ackerman Laboratory of Surgical Pathology, Barnes Jewish Hospital, Washington University Medical Center, St Louis, MO, USA
    J Cutan Pathol 30:190-5. 2003
    ..results in the fusion of two genes, collagen type I alpha 1(COL1A1) and platelet-derived growth factor B-chain (PDGFB)...
  44. ncbi [From cytogenetics to cytogenomics of dermatofibrosarcoma protuberans family of tumors]
    Laurence Bianchini
    Laboratoire de génétique des tumeurs solides, Centre hospitalier universitaire de Nice et CNRS UMR 6543, Faculte de Medecine, 28 Avenue de Valombrose, 06107 Nice
    Bull Cancer 94:179-89. 2007
    ..These chromosomal rearrangements lead to the formation of a specific fusion gene : COL1A1-PDGFB detected in rings as well as in translocations...
  45. doi COL1A1:PDGFB chimeric transcripts are not present in indeterminate fibrohistiocytic lesions of the skin
    Wei Lien Wang
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA
    Am J Dermatopathol 32:149-53. 2010
    ..dermatofibroma, DFSP harbors recurrent genetic aberrations resulting in the fusion of COL1A1 on chromosome 17 and PDGFB on chromosome 22...
  46. pmc Plasmodium falciparum and P. malariae epidemiology in a West African village
    C Boudin
    , , La Tronche, France
    Bull World Health Organ 69:199-205. 1991
    ..The parasitological sporozoite index (SI) was 4.48% for A. gambiae and 4.22% for A. funestus. The immunological SIs were higher: 5.82% of A. gambiae were infected with P. falciparum and only 0.16% with P...
  47. ncbi Renal function following sea snake venom (Lapemis hardwicki) administration in dogs treated with sodium bicarbonate solution
    K Sakwiwatkul
    Department of Physiology, Faculty of Veterinary Science, Chulalongkorn University, Queen Saovabha Memorial Institute, Thai Red Cross Society, Patumwan, Bangkok
    J Nat Toxins 11:111-21. 2002
    The effects of sea snake venom (SSV) on renal function were studied in two groups of anesthetized experimental dogs pretreated with intravenous infusion of 4.2 gm% NaHCO3 solution...
  48. doi Molecular diagnosis of dermatofibrosarcoma protuberans: a comparison between reverse transcriptase-polymerase chain reaction and fluorescence in situ hybridization methodologies
    Rocio Salgado
    Laboratori de Citogenètica Molecular, Servei de Patologia, GRETNHE, Programa de Recerca en Càncer, IMIM Institut de Recerca del Hospital del Mar, Parc de Salut Mar, Barcelona, Spain
    Genes Chromosomes Cancer 50:510-7. 2011
    ..DFSP) is characterized by the presence of the t(17;22)(q22;q13) that leads to the fusion of the COL1A1 and PDGFB genes...
  49. doi Complex t(5;8) involving the CSPG2 and PTK2B genes in a case of dermatofibrosarcoma protuberans without the COL1A1-PDGFB fusion
    Laurence Bianchini
    Laboratoire de génétique des tumeurs solides, Faculte de Medecine, Centre Hospitalier Universitaire de Nice, Universite de Nice Sophia Antipolis, Nice, France
    Virchows Arch 452:689-96. 2008
    ..These chromosomal rearrangements lead to the formation of a specific chimeric gene fusing COL1A1 to PDGFB. So far, the COL1A1-PDGFB fusion gene remains the sole fusion gene identified in DFSP...
  50. ncbi Scapular behavior in shoulder impingement syndrome
    Luc J Hebert
    Center for Interdisciplinary Research in Rehabilitation and Social Integration, Quebec Rehabilitation Institute, Quebec City, Que, Canada
    Arch Phys Med Rehabil 83:60-9. 2002
    ..scapular total range of motion (ROM) in both shoulders of persons with a unilateral shoulder impingement syndrome (SIS), to compare 3-dimensional (3D) scapular attitudes of their symptomatic and asymptomatic shoulders in flexion and ..
  51. doi PDGFB quantification is a useful tool in the diagnosis of dermatofibrosarcoma protuberans: a study of 10 cases
    F C Muchemwa
    Department of Dermatology and Plastic and Reconstructive Surgery, Kumamoto University Graduate School of Medical and Pharmaceutical Sciences, Kumamoto, Japan
    Clin Exp Dermatol 35:295-9. 2010
    Genetic aberrations involving the platelet-derived growth factor-beta (PDGFB) gene and the collagen type 1 alpha1 (COL1A1) gene have been implicated in the pathogenesis of dermatofibrosarcoma protuberans (DFSP), a slow-growing and ..
  52. ncbi [Possibility of prevention of herpes zoster by use of varicella vaccine]
    S Kawano
    Department of Pediatrics, Kawasaki Medical School
    Kansenshogaku Zasshi 72:714-9. 1998
    ..0 was estimated to be positive in this study. The SIs (mean +/- SD) before and after the vaccination were 2.7 +/- 1.8 and 2.7 +/- 1...
  53. doi Weak association of the platelet-derived growth factor beta (PDGFB) and PDGF receptor beta (PDGFRB) genes with schizophrenia and schizoaffective disorder
    Gwyneth Zai
    Neurogenetics Section, Centre for Addiction and Mental Health, Clarke Division, Toronto, Canada
    World J Biol Psychiatry 12:127-33. 2011
    ..One of the most convincing hypotheses comes from the dopaminergic system although none of the core genes has been consistently positive in association studies...
  54. ncbi Modulation of c-myc, c-myb, c-fos, c-sis and c-fms proto-oncogene expression and of CSF-1 transcripts and protein by phorbol diester in human malignant histiocytosis DEL cell line with 5q 35 break point
    J Gogusev
    Unite Inserm 90, Hospital Necker Enfants Malades, Paris, France
    Anticancer Res 13:1043-7. 1993
    ..C-myc, c-myb, c-fos, c-sis and c-fms expression were determined by Northern analysis at various times following TPA treatment...
  55. pmc Transformed dermatofibrosarcoma protuberans: real time polymerase chain reaction detection of COL1A1-PDGFB fusion transcripts in sarcomatous areas
    Zoltan Szollosi
    Department of Pathology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
    J Clin Pathol 60:190-4. 2007
    ..chromosomal rearrangements fuse the collagen type Ialpha1 (COL1A1) and the platelet-derived growth factor B-chain (PDGFB) genes...
  56. ncbi CD44 protein levels and its biological activity are regulated in Balb/c 3T3 fibroblasts by serum factors and by transformation with the ras but not with the sis oncogene
    P Kogerman
    Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Cell Physiol 169:341-9. 1996
    ..and hyaluronan-binding activity were investigated in Balb/c 3T3 cells and their derivatives transformed with ras or sis oncogenes as a function of serum concentration in the medium...
  57. ncbi Gene mutation analysis in five cases of dermatofibrosarcoma protuberans using formalin-fixed, paraffin-embedded tissues
    Hidehisa Saeki
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8655, Japan
    Acta Derm Venereol 85:221-4. 2005
    Fusion of the collagen type I a 1 (COL1A1) gene with the platelet-derived growth factor B-chain (PDGFB) gene has been pointed out in dermatofibrosarcoma protuberans...
  58. ncbi Basic fibroblast-like growth factor is present in the conditioned medium of simian sarcoma virus transformed NRK cells
    K Hicks
    Massachusetts Institute of Technology, Cambridge 02139
    Biochem Biophys Res Commun 164:1323-30. 1989
    ..these activities, we analyzed the medium for the presence of factors both related to and distinct from the v-sis oncogene product...
  59. ncbi Analysis of gene mutations in four cases of dermatofibrosarcoma protuberans
    H Saeki
    Aichi Medical University, Aichi, Japan
    Clin Exp Dermatol 31:441-4. 2006
    Fusion of the collagen type I alpha 1 (COL1A1) gene with the platelet-derived growth factor B-chain (PDGFB) gene has been described in dermatofibrosarcoma protuberans (DFSP)...
  60. ncbi A pilot study to evaluate the effectiveness of small intestinal submucosa used to repair spinal ligaments in the goat
    Eric H Ledet
    Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Spine J 2:188-96. 2002
    ..Small intestinal submucosa (SIS) is a naturally occurring extracellular collagen-based matrix, which is derived from porcine small intestine...
  61. pmc Autocrine stimulation by the v-sis gene product requires a ligand-receptor interaction at the cell surface
    M Hannink
    Department of Chemistry, University of California, San Diego, La Jolla 92093
    J Cell Biol 107:287-98. 1988
    ..We have constructed a NIH3T3 cell line which contains the v-sis gene under the inducible control of the Drosophila melanogaster hsp70 promoter...
  62. ncbi Psychological assessment of persons following suicide attempt by self-poisoning
    Gordana Dedic
    Military Medical Academy, Clinic for Psychiatry, Department for Mental Health and Military Psychology, Belgrade, Serbia
    Vojnosanit Pregl 67:151-8. 2010
    ....
  63. ncbi The effects of combined liquid and membrane barriers in prevention of post-operative intra-abdominal adhesions after experimental jejunal anastomosis in dogs
    W el-Ghoul
    Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt
    Dtsch Tierarztl Wochenschr 112:3-10. 2005
    ..In group four a natural biocompatible collagen sheet (VET BIO SIS T) was applied on the anastomosis site...
  64. ncbi [Experimental studies on canine bladder smooth muscle cells cultured on acellular small intestinal submucosa in vitro]
    Ping Han
    Division of Stem Cell and Tissue Engineering, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, PR China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 21:1366-70. 2007
    ..morphological characteristics of the bladder smooth muscle cells growing on acellular small intestinal submucosa(SIS) and offer an experimental basis for reconstruction of the bladder smooth muscle structure by the tissue ..
  65. doi Ultrasound imaging of the sural nerve: ultrasound anatomy and rationale for investigation
    S Ricci
    Università Campus Bio Medico di Roma, Area di Geriatria, Centro per la Salute dell Anziano, Roma, Italy
    Eur J Vasc Endovasc Surg 39:636-41. 2010
    Damage to the sural nerve (SuN) may arise from surgical stripping or thermal ablation of the small saphenous vein (SSV).
  66. ncbi Evaluation of proxy responses to the Stroke Impact Scale
    Pamela W Duncan
    Brooks Center for Rehabilitation Studies, University of Florida, and Rehabilitation Outcomes Research Center, North Florida South Georgia Department of Veteran Affairs, Gainesville, Fla 32610 0185, USA
    Stroke 33:2593-9. 2002
    The purposes of this study were to compare proxy-patient responses on each domain of the Stroke Impact Scale (SIS) and the SIS-16, estimate the bias, and evaluate the validity of proxy scores.
  67. ncbi Prevalence, anatomic patterns, valvular competence, and clinical significance of the Giacomini vein
    Konstantinos T Delis
    Department of Vascular Surgery, Imperial College School of Medicine, London, United Kingdom
    J Vasc Surg 40:1174-83. 2004
    Coursing the posterior thigh as a tributary or trunk projection of the small saphenous vein (SSV), the Giacomini vein's clinical significance in chronic venous disease (CVD) remains undetermined...
  68. ncbi [Effects of bone marrow mesenchymal stem cells enriched by small intestinal submucosal films on cardiac function and compensatory circulation after myocardial infarction in goats]
    Bin Liao
    Department of Thoracic and Cardiovascular Surgery, Affiliated Hospital of Luzhou Medical College, Luzhou Sichuan, 646000, PR China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 20:1248-52. 2006
    ..effects of the autologous bone mesenchymal stem cells (MSCs) enriched by the small intestinal submucosa (SIS) film implantation on the myocardial structure, cardiac function, and compensatory circulation after myocardial ..
  69. ncbi V-sis gene (SSV) is expressed transiently and independently of v-gag (SSAV) after infection of fibroblasts with SSV/SSAV
    H M Schätzl
    Max von Pettenkofer Institute for Hygiene and Medical Microbiology, University of Munich, Federal Republic of Germany
    Oncogene 4:1095-101. 1989
    To investigate the mechanism of cell transformation by the retroviral v-sis gene, we examined the mode of its mRNA expression after infection of primate fibroblasts with Simian Sarcoma Virus (SSV/SSAV)...
  70. ncbi Intrauterine lidocaine infusion for pain relief during saline solution infusion sonohysterography: a randomized, controlled trial
    Mehmet Guney
    Department of Obstetrics and Gynecology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey
    J Minim Invasive Gynecol 14:304-10. 2007
    To evaluate the efficacy of intrauterine lidocaine instillation in reducing patient discomfort during saline solution infusion sonohysterography (SIS).
  71. doi First results with a new 1470-nm diode laser for endovenous ablation of incompetent saphenous veins
    F Pannier
    Academisch Ziekenhuis Maastricht azM, Afdeling Dermatologie, Postbus 5800, AZ Maastricht, 6202, The Netherlands
    Phlebology 24:26-30. 2009
    ..Major side effects are postoperative pain and bruising. The aim of this study was to show the outcome one year after EVLA of incompetent saphenous veins with a 1470 nm Diode laser (Ceralas E, biolitec)...
  72. doi Arctic Ocean sea ice drift origin derived from artificial radionuclides
    P Cámara-Mor
    Institut de Ciencia i Tecnologia Ambientals, Universitat Autonoma de Barcelona, E 08193 Bellaterra, Spain
    Sci Total Environ 408:3349-58. 2010
    ..In this work, we present the results of anthropogenic radionuclide analyses of sea-ice sediments (SIS) collected on five cruises from different Arctic regions and combine them with a database including prior ..
  73. doi Comparison of different cryopreservation techniques: higher survival and implantation rate of frozen-thawed mouse pronuclear embryos in the presence of beta-mercaptoethanol in post-thaw culture
    H Bagis
    Medical Faculty and Medical Biology and Genetic Department, Adiyaman University, Adiyaman, Turkey
    Reprod Domest Anim 45:e332-7. 2010
    ..rate of mouse pronuclear (PN) embryos that were cryopreserved after slow freezing, solid surface vitrification (SSV) or open-pulled straw (OPS) vitrification methods...
  74. ncbi Characterization of v-sis protein expressed in silkworm larvae using the Bombyx mori nuclear polyhedrosis virus vector
    K Morishita
    Research Institute, Daiichi Pharmaceutical Co, Ltd, Tokyo
    J Biochem 109:36-44. 1991
    The v-sis oncogene of simian sarcoma virus encodes a protein which is homologous to the human platelet-derived growth factor B-chain...
  75. ncbi Major structural alterations of the c-sis gene are not observed in a series of tumors of the human central nervous system
    R D Press
    Department of Biochemistry, Case Western Reserve University Cleveland, OH 44106
    J Neurooncol 7:345-56. 1989
    Expression of the c-sis oncogene, the gene encoding the B chain of platelet-derived growth factor (PDGF), may be related to initiation and/or progression of glial cell tumorigenesis by PDGF-mediated autocrine growth stimulation...
  76. pmc The v-sis oncoprotein loses transforming activity when targeted to the early Golgi complex
    K C Hart
    Molecular Pathology Program, School of Medicine, University of California, San Diego, La Jolla 92093 0322
    J Cell Biol 127:1843-57. 1994
    The location of autocrine interactions between the v-sis protein and PDGF receptors remains uncertain and controversial...
  77. doi Endovenous laser treatment of the small saphenous vein
    Dimitrios Kontothanassis
    Istituto Flebologico Italiano, Ferrara Day Surgery, Ferrara, Italy
    J Vasc Surg 49:973-979.e1. 2009
    ..treatment is a minimally invasive technique for ablation of the incompetent great (GSV) and small saphenous vein (SSV). Compared with the GSV, fewer data are available on SSV laser ablation and are not validated...
  78. doi Biomechanical comparison of four soft tissue replacement materials: an in vitro evaluation of single and multilaminate porcine small intestinal submucosa, canine fascia lata, and polypropylene mesh
    Gregory A Arnold
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Vet Surg 38:834-44. 2009
    ..To compare mechanical performance of 4 soft tissue replacement materials...
  79. pmc The kinematics of upper extremity reaching: a reliability study on people with and without shoulder impingement syndrome
    Jean Sébastien Roy
    School of Rehabilitation Science, McMaster University, Hamilton, Ontario L8S 1C7, Canada
    Sports Med Arthrosc Rehabil Ther Technol 2:8. 2010
    ..A reaching task that evaluates impairment characteristics of people with shoulder impingement syndrome (SIS) was developed to evaluate the motor performance of this population...
  80. ncbi Transformation by v-sis occurs by an internal autoactivation mechanism
    B E Bejcek
    Department of Medicine, Jewish Hospital, Washington University Medical Center, St Louis, MO 63110
    Science 245:1496-9. 1989
    ..as predicted by the autocrine hypothesis because phenotypic transformation was not reversed by incubation of SSV-NRK cells with antisera to PDGF and because morphological transformation did not occur when nontransformed NRK ..
  81. ncbi Two secretory immune systems (mucosal and barrier) in human intrauterine development, normal and pathological (Review)
    Itshak Zusman
    Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot 76100, Israel
    Int J Mol Med 16:127-33. 2005
    The role of protein components of the secretory immune system (SIS), such as the polymeric immunoglobulin receptor/secretory component (pIgR/SC), immunoglobulins (Igs) and joining (J) chain, in human intrauterine development was reviewed...
  82. ncbi Surgical repair of deep melting ulcers with porcine small intestinal submucosa (SIS) graft in dogs and cats
    Maria Vanore
    Ophthalmology Unit, National Veterinary College of Alfort, 7 Avenue du General de Gaulle, 94700 Maisons Alfort, France
    Vet Ophthalmol 10:93-9. 2007
    To evaluate the efficacy of using a porcine small intestinal submucosa (SIS) graft for the surgical repair of deep melting ulcers in dogs and cats.
  83. ncbi Epidemiology of needlesticks and other sharps injuries and injection safety practices in the Dominican Republic
    Pedro L Moro
    Immunization Safety Office, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Am J Infect Control 35:552-9. 2007
    ..Contaminated sharps, such as needles, lancets, scalpels, broken glass, specimen tubes, and other instruments, can transmit bloodborne pathogens such as HIV, hepatitis B (HBV), and hepatitis C viruses (HCV)...
  84. doi Assessment of angiogenic properties of biomaterials using the chicken embryo chorioallantoic membrane assay
    Joseph Azzarello
    Department of Urology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
    Biomed Mater 2:55-61. 2007
    ..Five biomaterials including one-layer porcine small intestinal submucosa (SIS), two-layer SIS, four-layer vacuum pressed (VP) SIS, polyglycolic acid (PGA) and PGA modified with poly(lactic-co-..
  85. doi Validation of the sleep impact scale in patients with major depressive disorder and insomnia
    Kathryn Lasch
    Mapi Values, Boston, MA 02114, USA
    Curr Med Res Opin 25:1699-710. 2009
    ..This study aimed to assess the validity of the Sleep Impact Scale (SIS), a sleep-specific PRO instrument, in a population comorbid with Major Depressive Disorder (MDD) and insomnia to ..
  86. ncbi A comparative analysis of expanded polytetrafluoroethylene and small intestinal submucosa--implications for patch repair in ventral herniorrhaphy
    Thomas P Rauth
    Department of Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2577, USA
    J Surg Res 143:43-9. 2007
    ..This study compares the in vivo properties of two bioprosthetic products, small intestinal submucosa (SiS Gold; Cook Biotech, West Lafayette, IN) and lyophilized small intestinal submucosa (LyoSiS; Cook Biotech), with ..
  87. pmc Evidence that sisterless-a and sisterless-b are two of several discrete "numerator elements" of the X/A sex determination signal in Drosophila that switch Sxl between two alternative stable expression states
    T W Cline
    Biology Department, Princeton University, New Jersey 08544
    Genetics 119:829-62. 1988
    ..likely X/A signal target (the feminizing switch gene, Sex-lethal) and two positive regulators of that target gene (sis-a and daughterless)...
  88. ncbi Development to the blastocyst stage of parthenogenetically activated in vitro matured porcine oocytes after solid surface vitrification (SSV)
    Tamas Somfai
    Laboratory of Micromanipulation and Genetic Reprogramming, Institute of Animal Biology, Agricultural Biotechnology Center, Szent Gyorgyi Albert u 4, 2100 Gödöllő, Hungary
    Theriogenology 66:415-22. 2006
    The effects of solid surface vitrification (SSV) on viability and parthenogenetic development of in vitro matured (IVM) porcine oocytes was investigated in the present study...
  89. ncbi [Inhibition of c-sis protein synthesis and cell growth with antisense oligonucleotides in human glioma cells]
    T Nitta
    Department of Neurology and Genetics, Stanford University School of Medicine
    No Shinkei Geka 20:857-63. 1992
    The protein encoded by the proto-oncogene c-sis is over-amplified in human neuroglial tumors and has been hypothesized as playing an important role in tumorigenesis, but this hypothesis remains to be clarified...
  90. ncbi Decreased immunoreactivity of platelet-derived growth factor B chain-like peptide after axotomy in the dorsal motor nucleus of the vagus nerve
    E Yamada
    Department of Pathology, Shiga University of Medical Science, Otsu, Japan
    Brain Res 651:108-14. 1994
    ..The decrease in level of PDGF-B chain in the vagal neurons seems to cause the reduction of RNA and protein synthesis, resulting in neuronal degeneration...
  91. ncbi Isolation of a novel gene down-regulated by v-src
    J Pan
    Department of Tumor Virology, Research Institute for Microbial Diseases, Osaka University, Japan
    FEBS Lett 383:21-5. 1996
    ..its expression was also strongly suppressed in cells transformed by other oncogenes such as v-abl, v-fps, v-mos, v-sis, v-K-ras, and polyomavirus middle T, but not affected in cells transformed by human papillomavirus type 16 E6E7 and ..
  92. ncbi Regulation of epidermal growth factor receptor by activated H-ras and V-myc oncogenes in mouse Balb/3T3 cells: possible roles of AP-1
    T Okimoto
    Department of Biochemistry, Kyushu University, School of Medicine, Fukuoka, Japan
    Oncogene 12:1625-33. 1996
    ..the activated binding of a transcription factor, Stat1 p84/p91, which directly interacts with EGF receptor, to c-sis-inducible element (SIE) in both v-myc and H-rs/v-myc transfectants, but not in H-ras transfectants...
  93. ncbi STAT protein recruitment and activation in c-Kit deletion mutants
    M F Brizzi
    Department of Internal Medicine, University of Turin, Turin 10126, Italy
    J Biol Chem 274:16965-72. 1999
    ..Whereas STAT1alpha, possibly in the form of homodimers, binds to the sis-inducible DNA element, STAT5 proteins, either as STAT5A/STAT5B or STAT5/STAT1alpha heterodimers, bind to the ..
  94. ncbi Use of small intestinal submucosal implants for regeneration of large fascial defects: an experimental study in dogs
    L M Dejardin
    Laboratory for Comparative Orthopaedic Research, College of Veterinary Medicine, Michigan State University, East Lansing 48824 1314, USA
    J Biomed Mater Res 46:203-11. 1999
    A single layer of porcine small intestinal submucosa (SIS) was sutured into a 5 x 5 cm window created in the fascia lata of ten adult mongrel dogs in order to determine the efficacy of this material in promoting tissue regeneration of ..
  95. ncbi Significance of MIB-1 staining indices in meningiomas: comparison of two counting methods
    S Nakasu
    Department of Neurosurgery, Shiga University of Medical Science, Japan
    Am J Surg Pathol 25:472-8. 2001
    ..The MIB-1 staining indices (SIs) determined by the HL method were approximately twice as high as those by the RS method, and the correlation ..
  96. ncbi Laboratory diagnostics in vasculitis patients
    A Wiik
    Department of Autoimmunology, Statens Serum Institut, Copenhagen, Denmark
    Isr Med Assoc J 3:275-7. 2001
    ..a consensus-agreed technique combined with standardized enzyme immunoassays is the modality for detecting the main SSV-associated ANCA specificities using cutoff values that can sufficiently distinguish SVV from non-SVV patients...
  97. ncbi C3G-mediated suppression of oncogene-induced focus formation in fibroblasts involves inhibition of ERK activation, cyclin A expression and alterations of anchorage-independent growth
    Carmen Guerrero
    Centro de Investigacion del Cancer, IBMCC, Universidad de Salamanca CSIC, 37007 Salamanca, Spain
    Oncogene 23:4885-93. 2004
    ..releasing factor (GEF) for Rap1 and R-Ras proteins, blocks the focus-forming activity of cotransfected, activated, sis, ras and v-raf oncogenes in NIH 3T3 cells...
  98. ncbi Improved islet survival and in vitro function using solubilized small intestinal submucosa
    J R Lakey
    University of Alberta, Surgical Medical Research Institute, Department of Surgery, 1074 Dentistry Pharmacy Centre, Edmonton, T6G 2N8
    Cell Tissue Bank 2:217-24. 2001
    ..Small intestinal submucosa (SIS), a naturally occurring extracellular matrix, has been investigated to promote wound healing, tissue remodeling and ..
  99. ncbi Magnetic properties of isostructural BaCoP2O7, BaNiP2O7, and BaCuP2O7 studied with dc and ac magnetization and specific heat
    Alexei A Belik
    Institute for Chemical Research, Kyoto University, Uji, Kyoto fu 611 0011, Japan
    Inorg Chem 44:7523-9. 2005
    ..8 K (Hamiltonian H = J Sigma SiS(i+1)) and a temperature for the long-range magnetic order (TN) of 0.81 K giving the ratio kBTN/J = 0.78%...
  100. ncbi Long-term effects of porcine small intestine submucosa on the healing of medial collateral ligament: a functional tissue engineering study
    Rui Liang
    Musculoskeletal Research Center, Department of Bioengineering, University of Pittsburgh, 405 Center for Bioengineering, 300 Technology Drive, Pittsburgh, Pennsylvania 15219, USA
    J Orthop Res 24:811-9. 2006
    Porcine small intestinal submucosa (SIS) was previously shown to enhance the mechanical properties of healing medial collateral ligaments (MCL), and the histomorphological appearance and collagen type V/I ratio were found to be close to ..

Research Grants63

  1. Role of Acetaldehyde on PDGF-BB-induced HSC Migration and Proliferation.
    Raj M Lakshman; Fiscal Year: 2011
    ..Our long term goal is to unravel key molecular events triggered by acetaldehyde that could lead to therapeutic intervention and thus, to prevention and/or amelioration of alcohol-induced liver fibrosis and cirrhosis. ..
  2. ANALYSIS OF THE RECEPTOR FOR C-SIS PROTEIN
    Subal Bishayee; Fiscal Year: 1991
    Platelet derived growth factor (PDGF)--the product of c-sis proto-oncogene (p28sis), initiates cellular replication and transformation by binding to a high affinity cell surface receptor...
  3. Wei Zhang; Fiscal Year: 2014
    ..discovered that IGFBP2 is a novel oncogene that, when combined with K-ras or platelet-derived growth factor beta (PDGFB), leads to the development and progression of two major types of glioma (astrocytoma and oligodendroglioma) (..
  4. Dissecting Glioma Genesis through a Glial-Specific Mouse Model
    Wei Zhang; Fiscal Year: 2009
    ..found that IGFBP2 is a novel oncogene, which, when combined with K-ras or platelet-derived growth factor beta (PDGFB), leads to development and progression of two major types of diffuse glioma (astrocytoma and oligodendroglioma) (..
  5. Shilpa J Buch; Fiscal Year: 2016
    ..These studies are both novel and innovative in that the efficacy of PDGF-B in abrogating decreased neurogenesis can be of value not only for HAND but can be applicable to other neurodegenerative diseases as well. ..
  6. Infection-Prevention Barriers for Osseointegrated Percutaneous Implants
    David W Grainger; Fiscal Year: 2012
    ....
  7. MOLECULAR STUDIES OF TRANSFORMING GROWTH FACTORS
    Daniel Donoghue; Fiscal Year: 2001
    Since the discovery that the v-sis oncogene of Simian Sarcoma Virus encodes a homolog of platelet-derived growth factor (PDGF), the sis/PDGF system has yielded important information concerning signal transduction and cellular ..
  8. Acquired Resistance to VEGF blockade in Wilms tumor
    Jessica Kandel; Fiscal Year: 2007
    ..In Aim 1, we hypothesize that VEGF, in cooperation with ephrins, angiopoietins, and PDGFB, plays a critical role in forming vasculature with specific features that support aggressive behavior in WT...
  9. TROPHOBLAST PROLIFERATION AND GROWTH FACTOR EXPRESSION
    Robert Taylor; Fiscal Year: 1991
    ..resulting in the enhanced expression of a family of growth promoting genes, including the proto-oncogenes c-sis, c-myc, and c-fos...
  10. PDGF-MEDIATED GENE TRANSFER & PERIODONTAL WOUND HEALING
    William Giannobile; Fiscal Year: 2001
    ..Several vector constructs will be utilized in these studies: PDGF-B (c-sis); a negative control (the loss of function PDGF mutant (PDGF-1308); and lacZ...
  11. STATISTICAL GENETICS OF PDGF RELATED PHENOTYPES
    MICHAEL MAHANEY; Fiscal Year: 2000
    ....
  12. SYP AND GRB2 AND PDGF TRANSFORMATION
    BRUCE BEJCEK; Fiscal Year: 2000
    ..The discovery that the v-sis oncogene was homologous to the B-chain of the heterodimeric platelet-derived growth factor (PDGF) was one of the ..
  13. Regulation of Growth Factor Activity by A2 Macroglobulin
    STEVEN GONIAS; Fiscal Year: 2005
    ..abstract_text> ..
  14. Margaret Markiewicz; Fiscal Year: 2014
    ..Moreover, mRNA levels of several genes involved in the regulation of vessels stabilization such as PDGFB, VE-cadherin, N-cadherin were downregulated in the endothelial cells isolated from ER ? -/- mice...
  15. ROBERT CHARLES AUGUSTINE; Fiscal Year: 2014
    ..Defects in stress-induced SUMOylation (SIS) are associated with a number of human diseases including acute and chronic liver disease and cancer induced by ..
  16. Generating Blood-based Diagnosis for Alzheimer Disease
    Eugenia Wang; Fiscal Year: 2012
    ..SIRT1, whose reduction is known to be associated with increased Tau and A242, two hallmarks of AD etiopathogene- sis;our ultimate goal is a "Tool-Box" of TPR indices, miR-34a/SIRT1-TPR being the first such AD diagnostic, indicating ..
  17. PDGF AND NEOPLASTIC TRANSFORMATION
    HARRY ANTONIADES; Fiscal Year: 1993
    In vitro studies in cell culture have demonstrated the inappropriate expression of the c-sis/PDGF-2(B) proto-oncogene by responsive human malignant cell lines derived from human tumors of mesenchymal origin, such as glioblastomas, ..
  18. Cations and ROS in Modulating Mitochondrial Function in Normal and Ischemic Heart
    Ranjan K Dash; Fiscal Year: 2013
    ..functional defects in these processes can lead to mitochondrial dysfunction, cell death, and pathogene- sis of several diseases...
  19. Acetylation-Dependent IFN Signal Transduction
    Y Eugene Chin; Fiscal Year: 2010
    ..IFN activated STAT proteins also form homo- or hetero-dimer that bind to sis-inducible element (SIE) to regulate gene expression...
  20. Joseph G Gall; Fiscal Year: 2016
    ..This stable intronic sequence (sis) RNA is transmitted to the embryo at fertilization and persists during early development until at least the ..
  21. Epidemic CA-MRSA: Molecular Epidemiology and Immunology
    Robert S Daum; Fiscal Year: 2013
    ..About 375 children and adults with skin and soft tissue infections (SIs) will be enrolled for a period of three years at the University of Chicago...
  22. Syndecan-1 and the Arterial Response to Injury
    Alexander W Clowes; Fiscal Year: 2013
    ....
  23. RICHARD ELLIOT RINGEL; Fiscal Year: 2014
    ..Thus, a three-category Severity of Illness Scale (SIS) was developed for this trial, based on the clinical judgment of a panel of pediatric cardiologists...
  24. Actuated Fine-Gauge Spinal Needle Insertion to Reduce Dura Damage and PDPH Risk
    MAUREEN L MULVIHILL; Fiscal Year: 2012
    ..AMI), (formerly Piezo Resonance Innovations, Inc) will develop and test the Actuated Spinal Anesthesia (SIS or 'Smooth Insertion Spinal') Needle Insertion Tool to Reduce Dural Damage and Post Dural Puncture ..
  25. Synthetic Scaffolds for Bladder Regeneration
    Sundararajan Madihally; Fiscal Year: 2009
    ..Small intestinal submucosa (SIS), a natural biodegradable matrix, has shown significant success in bladder regeneration...
  26. Andrea C Gielen; Fiscal Year: 2016
    ..Our previous work, including the NICHD-funded study of Safety in Seconds (SIS) and that of others, has demonstrated that computer-tailored interventions can be feasible and effective in ..
  27. FUNCTION OF THE SUBUNITS OF EUKARYOTIC CHROMOSOMES
    WILLIAM GARRARD; Fiscal Year: 2013
    ..that contain B-cell-specific and developmentally regulated DNase I hypersensitive sites (HSs): (1) A silencer (Sis) within the intervening sequence between the joining (J?) region and the most proximal V? gene, which upon V? - J? ..
  28. 3D Acellular Vascular Beds: Characterization and Re-endothelialization
    Christine E Schmidt; Fiscal Year: 2012
    ..g., SIS products from Cook Biotech, AlloDerm from LifeCell, and Avance from AxoGen;note: the Avance nerve graft is based on ..
  29. Screening for new therapies for refractory infantile spasms
    Aristea S Galanopoulou; Fiscal Year: 2013
    ..role of this model as a preclinical screening tool for the identification of new therapies for medically-refractory SIS with rapid onset, sustained effect, and disease-modifying potential...
  30. Peter J Dempsey; Fiscal Year: 2016
    ..have expanded our knowledge on the importance of ADAM10 signaling in ISC populations during intestinal homeosta- sis under normal and regenerative conditions, evaluated its contribution to the regulation of progenitor cell ..
  31. MARY SUSAN HAMMES; Fiscal Year: 2015
    ..Significance: The care and outcome of the patient with end stage renal disease (ESRD) on chronic hemodialy- sis is directly dependent on their hemodialysis access...
  32. Ki-Ras Signaling in Pancreatic Cancer: Role of a Novel Akt Regulator
    Sushovan Guha; Fiscal Year: 2013
    ..BSTA will be also be downregulated in PDAC cells to investigate tumorigene- sis and resistance to mTOR inhibitors in an orthotopic mouse model...
  33. Eugenia Trushina; Fiscal Year: 2015
    ..Lack of such knowledge limits development of tools for early diagno- sis, monitoring disease progression, and design of efficient therapeutic strategies for neurodegenerative disor- ders...
  34. Stabilization of Membrane Protein Signaling Complexes
    T M Iverson; Fiscal Year: 2013
    ..Following synthe- sis, we will monitor the stability of each complex using peptide detergents in isolation or in combination with ..
  35. EVOLUTIONARY MODELS OF THE IMMUNE SYSTEM
    Melvin Cohn; Fiscal Year: 2010
    ..These theories will be linked together by a computer program referred to as SIS, the Synthetic Immune System. The success of this approach will be seen in several ways...
  36. Interdisciplinary Comprehensive Arm Rehab Evaluation (I-CARE) Stroke Initiative
    Steven L Wolf; Fiscal Year: 2013
    ..outcomes include patients'self-perception of paretic hand function, a domain of the Stroke Impact Scale (SIS) and the full SIS...
  37. Uterine In-vivo Strain Imaging Using Saline Infusion
    Tomy Varghese; Fiscal Year: 2010
    ..between mechanical deformation and data acquisition in the uterus for in vivo saline induced sonohysterography (SIS) based strain imaging will be studied using anthropomorphic phantoms...
  38. Splice isoform-specific RNAi as therapy for Spinocerebellar Ataxia type 6
    Edgardo Rodriguez; Fiscal Year: 2012
    ..The preclinical studies proposed here will test a novel splice-isoform- specific RNA interference (SIS-RNAi) therapy approach for SCA6, using a genetically accurate mouse model of the disease...
  39. Dissecting the opposing roles of alpha-3 integrin in metastasis
    Christopher S Stipp; Fiscal Year: 2013
    ..Our long term goal is to understand how tumor-host interactions can be manipulated to inhibit tumor cell metasta- sis. The objectives of this application are to (i) determine the role of [unreadable]3[unreadable]1 integrin in ..
  40. J Peter Rubin; Fiscal Year: 2016
    ..differentiation of human preadipocytes within macroporous collagenous beads and small intestinal submucosa (SIS) microparticles in culture. 3...
  41. Reinhard R Beichel; Fiscal Year: 2014
    ..with high radiodensity pathology caused by significant inflammation, consolidation, alveolar flooding or fibro- sis was not successful up to now due to the lack of automated robust lung image analysis techniques...
  42. Monica T Hinds; Fiscal Year: 2014
    ..the central hypothesis of this proposal is that modification of the surface of small intestinal submucosa (SIS) leaflets will enable the capture and growth of functional EPCs in order to modulate the in vivo biologic responses ..
  43. SIS multicenter study of duration of antibiotics for intraabdominal infection
    Robert G Sawyer; Fiscal Year: 2011
    ....
  44. Magnetic Resonance Imaging Subsystem for Evaluation of Valvular Disease
    Juan M Santos; Fiscal Year: 2012
    ..for the assessment of wall motion, valvular morphology, color flow mapping and quantitation of valvular steno- sis. We have also established the feasibility of rapidly quantitating each of these parameters...
  45. A Study of Social Web Data on Buprenorphine Abuse Using Semantic Web Technology
    Amit P Sheth; Fiscal Year: 2012
    ..e.sis) at Wright State University...
  46. EXPRESSION OF CYSTATHIONINE SYNTHASE AND HUMAN DISEASE
    JAN KRAUS; Fiscal Year: 1993
    ..address the mechanism < synthase interaction with S-adenosylmethionine and its activation by specific proteoly-sis which yields 48 kDa subunits with increased catalytic activity; 5) to provide evidence at a molecular level that ..
  47. A COMPARISON OF IN VIVO AND VITRO TISSUE ENGINEERING
    Bradley Kropp; Fiscal Year: 2004
    ..The most successful results utilizing in vivo techniques have been with the biomaterial small intestinal submucosa (SIS)...
  48. BIOCHEMICAL APPROACH TO PERIODONTAL REGENERATION
    VICTOR TERRANOVA; Fiscal Year: 1993
    ..of PDL-CTX and bFGF, PDGF and TGFBeta will be examined in relationship to the expression of FN, actin, c-myc, c-sis and c-fos. We will next establish the phenotype characteristic of the "young" PDL cells...
  49. FIBRONECTIN--PROTEOGLYCAN BINDING IN ADHESION SITES
    LLOYD CULP; Fiscal Year: 1993
    ..of these adhesion processes upon oncogenic virus (Kirsten murine sarcoma virus) transformation or oncogene (Ras/Sis/erbB) transfection...
  50. PHARMACOLOGIC AND MOLECULAR CONTROL OF C-JUN IN LEUKEMIA
    MATTHEW SHERMAN; Fiscal Year: 1992
    ..contrast to the down-regulation of c-- myc RNA levels, monocytic differentiation is associated with increases in c-sis, c-fos, and TNF transcripts...
  51. A NOVEL COLORIMETRIC ENZYME ASSAY FOR FIBRINOLYSIS
    Mark Triscott; Fiscal Year: 1990
    We have recently developed an assay system for the components of the fibrinolytic pathway. This novel assays sis based on a solid phase enzyme linked fibrin matrix in which plasmin is measured by the release of enzyme from the matrix...
  52. IGF EXPRESSION IN NORMAL AND DIABETIC PREGNANCY
    Judith Ilan; Fiscal Year: 1991
    ..The alteration in the rate of transcription will be followed by "run-on" nuclear assays and the role of specific mRNA degradation will be followed by pulse- experiments...
  53. DISSECTION OF CAPS FUNCTION IN CHROMAFFIN CELL SECRETION
    Cristina Artalejo; Fiscal Year: 2004
    ..As such, we are interested in the elucidation of the molecular machinery that distinguishes DCV and SSV exocytosis...
  54. Modified Cotton Dressings for Treating Chronic Wounds
    Irwin Cohen; Fiscal Year: 2002
    ..PROPOSED COMMERCIAL APPLICATIONS: The total cost for treating chronic wound sis estimated at $22-26 bn (Page 11), the cost of dressings used is in excess of $1 bn (Page 13)...
  55. BIOCHEMISTRY OF PSORIATIC BLOOD VESSELS
    Marvin Karasek; Fiscal Year: 1990
    ..monolayers by induction of new vessels by collagen gels and the modulation of 4 proto-oncogenes (c-ras, c- myc, c-sis, and c-fos) will be determined by Northern blot analysis...
  56. ROLES OF MEMBRANE AND SOLUBLE KL IN HEMATOPOIESIS
    Peter Besmer; Fiscal Year: 2002
    ..Kit-Ligand (KL), the ligand of the Kit receptor tyrosine kinase, is encoded at the Sl locus and mice carrying SIS mutations have defects in hematopoiesis, gametogenesis and melanogenesis...
  57. RESEARCH TRAINING IN ONCOLOGY IMAGING
    Zaver Bhujwalla; Fiscal Year: 2001
    ..delivery of drugs active in the treatment of brain tumors, development of inhibitors of tumor angiogene-sis, applications of bioerodible, sustained-release polymers, monitoring of the proliferative state and therapeutic ..
  58. ETIOLOGY OF ESTROGEN INDUCED PROLACTIN TUMORS
    Richard Weiner; Fiscal Year: 1991
    ..mRNA levels will be determined for int-2 and hst which have considerable homology with FGF as well as erb-B, sis, Ha-ras, N-ras, Ki-ras, fos and myc...
  59. CORONARY-PRONE BEHAVIOR AND CARDIOVASCULAR REACTIVITY
    THEODORE DEMBROSKI; Fiscal Year: 1990
    ..guided the development of a matched case-control design in which component reanalysis of structured interviews (SIs) in the prospective Multiple Risk Factor Intervention trial (MRFIT) showed a significant positive association ..
  60. Spatial-Temporal MEG and EEG Source Estimation
    Richard Leahy; Fiscal Year: 2009
    ..This work focused primarily on analy- sis of event-related averaged data in single subjects. Statistical analysis was restricted to pair-wise compari- sons...
  61. TARGETING OF BRAIN PROTEIN PHOSPHATASE 1
    ROGER COLBRAN; Fiscal Year: 2002
    ..example, activation of type 1 protein phosphatase catalytic subunit (PP1C) isoforms localized in dendritic spine sis likely important in the induction of long-term depression...
  62. Functional Tissue Engineering for Stress Incontinence
    Michael Chancellor; Fiscal Year: 2006
    ..Hypothesis: 1) Muscle Derived Stem Cells (MDSC) improve the mechanical properties of small intestinal submucosa (SIS) scaffold in vitro. 2) MDSC/SIS suburethral sling improves continence in an in vivo rat model of SUI...

Patents2

  1. MULTICISTRONIC EXPRESSION UNITS AND THEIR USE
    Patent Number: WO9405785-A1; Date:1994-03-17
  2. PRODUCTION OF HETERODIMER PDGF-AB BY MEANS OF A BICISTRONIC VECTOR SYSTEM IN MAMMALIAN CELLS
    Patent Number: WO9405786-A1; Date:1994-03-17