PDGFA

Summary

Gene Symbol: PDGFA
Description: platelet derived growth factor subunit A
Alias: PDGF-A, PDGF1, platelet-derived growth factor subunit A, PDGF A-chain, PDGF subunit A, platelet-derived growth factor A-chain, platelet-derived growth factor alpha chain, platelet-derived growth factor alpha polypeptide
Species: human

Top Publications

  1. ncbi Platelet-derived growth factor up-regulates the expression of transcription factors NF-E2, GATA-1 and c-Fos in megakaryocytic cell lines
    Cecilia Mei Yan Chui
    Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, 6th Floor, Clinical Sciences Building, Shatin, N T, Hong Kong, People s Republic of China
    Cytokine 21:51-64. 2003
  2. pmc Phosphorylation of the carboxyl-terminal transactivation domain of c-Fos by extracellular signal-regulated kinase mediates the transcriptional activation of AP-1 and cellular transformation induced by platelet-derived growth factor
    Paula Monje
    Oral and Pharyngeal Cancer Branch, National Institute of Dental Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 4330, USA
    Mol Cell Biol 23:7030-43. 2003
  3. pmc Long-term exposure of proximal tubular epithelial cells to glucose induces transforming growth factor-beta 1 synthesis via an autocrine PDGF loop
    Donald Fraser
    Institute of Nephrology, University of Wales College of Medicine, Heath Park, Cardiff, Wales, United Kingdom
    Am J Pathol 163:2565-74. 2003
  4. pmc The extracellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF)-AB and -BB and inhibits the binding of PDGF to its receptors
    E W Raines
    Department of Pathology, University of Washington, Seattle 98195
    Proc Natl Acad Sci U S A 89:1281-5. 1992
  5. pmc cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor
    L Claesson-Welsh
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden
    Proc Natl Acad Sci U S A 86:4917-21. 1989
  6. ncbi Signal transduction via platelet-derived growth factor receptors
    C H Heldin
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden
    Biochim Biophys Acta 1378:F79-113. 1998
  7. ncbi Mechanism of action and in vivo role of platelet-derived growth factor
    C H Heldin
    Ludwig Institute for Cancer Research, Biomedical Center, and Department of Pathology, University Hospital, Uppsala, Sweden
    Physiol Rev 79:1283-316. 1999
  8. ncbi PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor
    X Li
    Ludwig Institute for Cancer Research, Stockholm, Sweden
    Nat Cell Biol 2:302-9. 2000
  9. ncbi The proteolytic processing of pro-platelet-derived growth factor-A at RRKR(86) by members of the proprotein convertase family is functionally correlated to platelet-derived growth factor-A-induced functions and tumorigenicity
    Geraldine Siegfried
    Laboratory of Biochemical Neuroendocrinology Clinical Research Institute of Montreal, Montreal, Quebec, H2W 1R7, Canada
    Cancer Res 63:1458-63. 2003
  10. ncbi Expression of platelet-derived growth factors and their receptors in ovarian clear-cell carcinoma and its putative precursors
    Sohei Yamamoto
    Department of Basic Pathology, National Defense Medical College, Tokorozawa, Saitama, Japan
    Mod Pathol 21:115-24. 2008

Research Grants

  1. Harish Vasudevan; Fiscal Year: 2015
  2. Dysregulation of the Tumor Microenvironment in Hepatocellular Carcinoma
    Lewis R Roberts; Fiscal Year: 2010
  3. UNIQUE GLIAL CELL POPULATION IN THE BRAIN
    Akiko Nishiyama; Fiscal Year: 1999
  4. PLATELET AND CELL GROWTH--ROLE OF PDGF
    THOMAS DEUEL; Fiscal Year: 2002
  5. Stephen E McGowan; Fiscal Year: 2016
  6. BASIS OF PAX3-FKHR ONCOGENESIS IN RHABDOMYOSARCOMA
    Chiayeng Wang; Fiscal Year: 2001
  7. PDGF SIGNALING IN OLIGODENDROCYTE DEVELOPMENT
    RANDALL MCKINNON; Fiscal Year: 2004
  8. DOMINANT NEGATIVE PDGF RECEPTORS IN AIRWAY FIBROSIS
    Melissa King; Fiscal Year: 2000
  9. Mechanisms of Pulmonary Vein Development
    Steven B Bleyl; Fiscal Year: 2010
  10. PHILIPPE M SORIANO; Fiscal Year: 2016

Patents

  1. Recombinant platelet-derived growth factor A-chain derived from endothelial cells
  2. MULTICISTRONIC EXPRESSION UNITS AND THEIR USE
  3. PRODUCTION OF HETERODIMER PDGF-AB BY MEANS OF A BICISTRONIC VECTOR SYSTEM IN MAMMALIAN CELLS
  4. MULTICISTRONIC EXPRESSION OF RECOMBINANT GENES IN BACTERIAL CELLS

Detail Information

Publications225 found, 100 shown here

  1. ncbi Platelet-derived growth factor up-regulates the expression of transcription factors NF-E2, GATA-1 and c-Fos in megakaryocytic cell lines
    Cecilia Mei Yan Chui
    Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, 6th Floor, Clinical Sciences Building, Shatin, N T, Hong Kong, People s Republic of China
    Cytokine 21:51-64. 2003
    ..Our data suggest a direct stimulatory effect of PDGF on c-Fos, GATA-1 and NF-E2 expressions and we speculate that these transcription factors might be involved in the signal transduction of PDGF on the regulation of megakaryocytopoiesis...
  2. pmc Phosphorylation of the carboxyl-terminal transactivation domain of c-Fos by extracellular signal-regulated kinase mediates the transcriptional activation of AP-1 and cellular transformation induced by platelet-derived growth factor
    Paula Monje
    Oral and Pharyngeal Cancer Branch, National Institute of Dental Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 4330, USA
    Mol Cell Biol 23:7030-43. 2003
    ..Furthermore, we provide evidence that the ERK-dependent activation of c-Fos is an integral component of the mitogenic pathway by which PDGF regulates normal and aberrant cell growth...
  3. pmc Long-term exposure of proximal tubular epithelial cells to glucose induces transforming growth factor-beta 1 synthesis via an autocrine PDGF loop
    Donald Fraser
    Institute of Nephrology, University of Wales College of Medicine, Heath Park, Cardiff, Wales, United Kingdom
    Am J Pathol 163:2565-74. 2003
    ..This provides a potential explanation for the clinical observation that prolonged poor glycemic control may contribute to progression of diabetic nephropathy...
  4. pmc The extracellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF)-AB and -BB and inhibits the binding of PDGF to its receptors
    E W Raines
    Department of Pathology, University of Washington, Seattle 98195
    Proc Natl Acad Sci U S A 89:1281-5. 1992
    ..We suggest that the coordinate expression of SPARC and PDGF-B-containing dimers following vascular injury may regulate the activity of specific dimeric forms of PDGF in vivo...
  5. pmc cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor
    L Claesson-Welsh
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden
    Proc Natl Acad Sci U S A 86:4917-21. 1989
    ..led to the expression of a protein specifically recognized by an antiserum previously shown to react with the PDGF A-type receptor...
  6. ncbi Signal transduction via platelet-derived growth factor receptors
    C H Heldin
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden
    Biochim Biophys Acta 1378:F79-113. 1998
    ..Recent observations suggest that extensive cross-talk occurs between different signaling pathways, and that stimulatory signals are modulated by inhibitory signals arising in parallel...
  7. ncbi Mechanism of action and in vivo role of platelet-derived growth factor
    C H Heldin
    Ludwig Institute for Cancer Research, Biomedical Center, and Department of Pathology, University Hospital, Uppsala, Sweden
    Physiol Rev 79:1283-316. 1999
    ..This review discusses structural and functional properties of PDGF and PDGF receptors, the mechanism whereby PDGF exerts its cellular effects, and the role of PDGF in normal and diseased tissues...
  8. ncbi PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor
    X Li
    Ludwig Institute for Cancer Research, Stockholm, Sweden
    Nat Cell Biol 2:302-9. 2000
    ....
  9. ncbi The proteolytic processing of pro-platelet-derived growth factor-A at RRKR(86) by members of the proprotein convertase family is functionally correlated to platelet-derived growth factor-A-induced functions and tumorigenicity
    Geraldine Siegfried
    Laboratory of Biochemical Neuroendocrinology Clinical Research Institute of Montreal, Montreal, Quebec, H2W 1R7, Canada
    Cancer Res 63:1458-63. 2003
    ..Chinese hamster ovary cells overexpressing pro-PDGF-A (ARKA(86)) failed to induce tumors in nude mice. Thus, PC-directed inhibitors might represent new agents for therapy in neoplasia induced by PDGF-A...
  10. ncbi Expression of platelet-derived growth factors and their receptors in ovarian clear-cell carcinoma and its putative precursors
    Sohei Yamamoto
    Department of Basic Pathology, National Defense Medical College, Tokorozawa, Saitama, Japan
    Mod Pathol 21:115-24. 2008
    ....
  11. doi Platelet-derived growth factors (PDGF-A and -B) and their receptors in human fetal and adult ovaries
    H Pinkas
    IVF Research Laboratory, Infertility and IVF Unit, Helen Schneider Hospital for Women, Rabin Medical Center, Beilinson Campus, Petach Tikva 49100, Israel
    Mol Hum Reprod 14:199-206. 2008
    ..PDGF-A and -B transcripts were identified in all the extracts. The presence of the receptors in GC suggests that PDGFs might be involved in the activation of primordial follicles...
  12. pmc High expression of HIF1a is a predictor of clinical outcome in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA, VEGF, and bFGF
    Andreas Claudius Hoffmann
    Department of Biochemistry and Molecular Biology and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA
    Neoplasia 10:674-9. 2008
    ..In this study, we investigated the prognostic values of HIF1a, bFGF, VEGF, and PDGFA gene expressions as well as their interrelationships.
  13. doi PDGF receptor signaling networks in normal and cancer cells
    Jean Baptiste Demoulin
    de Duve Institute, Universite Catholique de Louvain, Brussels, Belgium Electronic address
    Cytokine Growth Factor Rev 25:273-83. 2014
    ..Of particular interest, recent studies revealed significant differences between normal and cancer cells regarding signal transduction by these growth factors. ..
  14. pmc Promoter region of the human platelet-derived growth factor A-chain gene
    Y Takimoto
    Department of Medicine, Jewish Hospital, Washington University Medical Center, St Louis, MO 63110
    Proc Natl Acad Sci U S A 88:1686-90. 1991
    ..DNA sites of potential importance in mediating the activation of the PDGF A-chain gene in normal cells and in transformed cell lines expressing high levels of PDGF A chain were identified.
  15. ncbi The growth-inhibitory block of TGF-beta is located close to the G1/S border in the cell cycle
    D Kletsas
    Institute of Biology, N C S R Demokritos, Athens, Greece
    Exp Cell Res 217:477-83. 1995
    ....
  16. ncbi Effects of PDGF A-chain antisense oligodeoxynucleotides on growth of cardiovascular organs in stroke-prone spontaneously hypertensive rats
    H Kishioka
    Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan
    Am J Hypertens 14:439-45. 2001
    ..Expression of PDGF A-chain mRNA was higher in the aorta and kidney in 9-week-old SHR-SP than in Wistar-Kyoto (WKY) rats...
  17. ncbi Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors
    Nathalie A Lokker
    Millennium Pharmaceuticals, Inc, South San Francisco, California 94080, USA
    Cancer Res 62:3729-35. 2002
    ..Together these findings demonstrate the potential therapeutic utility of this class of compounds for the treatment of glioblastoma...
  18. ncbi [Roles of vascular endothelial growth factor and platelet-derived growth factor in lymphangiogenesis in epithelial ovarian carcinoma.]
    Rong Wei Zhao
    Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    Zhonghua Fu Chan Ke Za Zhi 44:760-4. 2009
    ..To assess roles of vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) in the mechanisms of lymphangiogenesis in epithelial ovarian carcinoma...
  19. ncbi Effect of ischemic preconditioning on pancreatic regeneration and pancreatic expression of vascular endothelial growth factor and platelet-derived growth factor-A in ischemia/reperfusion-induced pancreatitis
    A Dembinski
    Department of Physiology, Jagiellonian University Medical College, Krakow, Poland
    J Physiol Pharmacol 57:39-58. 2006
    ....
  20. doi Platelet-derived growth factor isoform expression in carbon tetrachloride-induced chronic liver injury
    Erawan Borkham-Kamphorst
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital Aachen, Aachen, Germany
    Lab Invest 88:1090-100. 2008
    ....
  21. ncbi Expression of platelet-derived growth factor (PDGF) in the epididymis and analysis of the epididymal development in PDGF-A, PDGF-B, and PDGF receptor beta deficient mice
    Sabrina Basciani
    Department of Medical Pathophysiology, University of Rome La Sapienza, Policlinico Umberto I, 00161 Rome, Italy
    Biol Reprod 70:168-77. 2004
    ..mesonephric origin of the epididymis and kidney prompted us to investigate the immunohistochemical localization of PDGF A- and B-chain and PDGF receptor (PDGFR) alpha- and beta-subunit in rat and mouse epididymis, the expression ..
  22. ncbi A high level of CCAAT-enhancer binding protein-delta expression is a major determinant for markedly elevated differential gene expression of the platelet-derived growth factor-alpha receptor in vascular smooth muscle cells of genetically hypertensive rats
    Y Kitami
    Second Department of Internal Medicine, Ehime University School of Medicine, Onsen gun, Ehime, Japan
    Circ Res 84:64-73. 1999
    ..These findings indicate that differential expression of members of the C/EBP family, mainly C/EBP-delta and possibly C/EBP-beta, are responsible for the strain-specific gene transcription of PDGF-alphaR in VSMCs...
  23. doi Platelet-derived growth factor (PDGF) and PDGF receptor expression and function in folliculostellate pituitary cells
    M Kowarik
    Max Planck Institute of Psychiatry, Neuroendocrinology Group, D 80804Munich, Germany
    Exp Clin Endocrinol Diabetes 118:113-20. 2010
    ..Thus the PDGF/PDGF receptor system is expressed in folliculostellate cells and is involved in VEGF regulation. Its role in endocrine pituitary tumour cell lines and pituitary adenomas need to be clarified in future studies...
  24. ncbi Rapid disruption of gap junctional communication and phosphorylation of connexin43 by platelet-derived growth factor in T51B rat liver epithelial cells expressing platelet-derived growth factor receptor
    M Z Hossain
    Department of Molecular Medicine, Northwest Hospital, Seattle, Washington 98125, USA
    J Cell Physiol 174:66-77. 1998
    ..This report describes a suitable cell system which is currently being utilized for the characterization of the PDGF signaling pathway responsible for the inhibition of GJC...
  25. ncbi Expression of platelet-derived growth factor-AA is associated with tumor progression in osteosarcoma
    Irene Sulzbacher
    Clinical Institute of Pathology, University of Vienna Medical School, Vienna, Austria
    Mod Pathol 16:66-71. 2003
    ..021, Cox regression). Immunohistochemical analysis of platelet-derived growth factor-AA expression in osteosarcoma may be a useful marker of prognosis and may be considered as a possible target for novel therapeutic strategies...
  26. ncbi Immunohistochemical expression of FGF-2, PDGF-A, VEGF and TGF beta RII in the pancreas in the course of ischemia/reperfusion-induced acute pancreatitis
    Z Warzecha
    Department of Physiology, Jagiellonian University Medical School, 16 Grzegorzecka Street, 31 531 Krakow, Poland
    J Physiol Pharmacol 55:791-810. 2004
    ..The aim of our study was to evaluate the presence of growth factors in the course of spontaneous pancreatic regeneration after ischemia/reperfusion (I/R)-induced pancreatitis...
  27. ncbi A unique autophosphorylation site in the platelet-derived growth factor alpha receptor from a heterodimeric receptor complex
    E Rupp
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden
    Eur J Biochem 225:29-41. 1994
    ....
  28. pmc Phosphorylation of tyrosine 720 in the platelet-derived growth factor alpha receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation
    C E Bazenet
    Division of Basic Sciences, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206, USA
    Mol Cell Biol 16:6926-36. 1996
    ..In addition, these findings reveal that while SHP-2 binds to both of the receptors, it binds in different locations: to the carboxy terminus of the betaPDGFR but to the kinase insert of the alphaPDGFR...
  29. ncbi A role for Src in signal relay by the platelet-derived growth factor alpha receptor
    J A Gelderloos
    The Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 273:5908-15. 1998
    ..Finally, activation of Src during the G0/G1 transition does not appear to be required for latter cell cycle events such as induction of c-myc or cell proliferation...
  30. ncbi [Effect of truncated platelet-derived growth factor-alpha receptor on apoptosis and expression of c-sis mRNA of pulmonary artery smooth muscle cells]
    Han Min Liu
    Department of Pediatrics, The West China Second Hospital, Sichuan University, Chengdu 610041, China
    Zhonghua Er Ke Za Zhi 41:329-33. 2003
    ..The study aimed to investigate the effect of truncated PDGF-alpha receptor on apoptosis and expression of c-sis mRNA of pulmonary artery smooth muscle cells (VSMCs)...
  31. pmc Platelet-derived growth factor (PDGF) gene delivery for application in periodontal tissue engineering
    W V Giannobile
    Department of Periodontics Prevention Geriatrics and Center for Biorestoration of Oral Health, The University of Michigan, Ann Arbor 48109 1078, USA
    J Periodontol 72:815-23. 2001
    ..Recent advances in gene therapy offer the advantage of delivering recombinant proteins to tissues for extended periods of time in vivo...
  32. ncbi Spatial and temporal localization of transforming growth factor-beta1, bone morphogenetic protein-2, and platelet-derived growth factor-A in healing tooth extraction sockets in a rabbit model
    Zahid Lalani
    Department of Oral and Maxillofacial Surgery, University of Texas Health Science Center at Houston, 6516 M D Anderson Boulevard, Suite DBB 2 059, Houston, TX 77030, USA
    J Oral Maxillofac Surg 61:1061-72. 2003
    ....
  33. doi The involvement of platelet-derived growth factor-A in the course of apical periodontitis
    L Wang
    Department of Operative Dentistry and Endodontics, School and Hospital of Stomatology, Wuhan University, Wuhan, China
    Int Endod J 44:65-71. 2011
    ..To investigate the expression of platelet-derived growth factor-A (PDGF-A) in the course of apical periodontitis induced in rats and to explore its possible role in the development of periapical lesions...
  34. ncbi Immunohistochemical detection of insulin-like growth factors, platelet-derived growth factor, and their receptors in ameloblastic tumors
    H Kumamoto
    Division of Oral Pathology, Department of Oral Medicine and Surgery, Tohoku University Graduate School of Dentistry, Sendai, Japan
    J Oral Pathol Med 36:198-206. 2007
    ....
  35. ncbi Coordinate regulation by diethylstilbestrol of the platelet-derived growth factor-A (PDGF-A) and -B chains and the PDGF receptor alpha- and beta-subunits in the mouse uterus and vagina: potential mediators of estrogen action
    K Gray
    Laboratory of Developmental and Reproductive Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Endocrinology 136:2325-40. 1995
    ..After DES treatment, the uterus exhibits a significant decrease in the level of PDGF ligand and receptor proteins immunostained within 6 h, whereas less dramatic effects ar observed in the vagina.(ABSTRACT TRUNCATED AT 400 WORDS)..
  36. ncbi Determination of cytokine mRNA-expression in term human placenta of patients with gestational hypertension, intrauterine growth retardation and gestational diabetes mellitus using polymerase chain reaction
    J Heinig
    Biochemical Institute of the University of Rostock
    Zentralbl Gynakol 122:413-8. 2000
    ....
  37. ncbi [The effect of platelet-derived growth factor on the formation of proliferative vitreoretinopathy]
    Yong Liang
    Department of Ophthalmology, People s Hospital, Beijing University, Beijing 100044, China Email
    Zhonghua Yan Ke Za Zhi 38:144-7. 2002
    ..To study the actions of platelet-derived growth factor (PDGF) in proliferative membrane formation of proliferative vitreoretinopathy (PVR) and whether there is the existence of PDGF secreting cells and target cells...
  38. ncbi Osteopontin expression in platelet-derived growth factor-stimulated vascular smooth muscle cells and carotid artery after balloon angioplasty
    X Wang
    Department of Cardiovascular Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA
    Arterioscler Thromb Vasc Biol 16:1365-72. 1996
    ....
  39. doi Effects of platelet-derived growth factor on aqueous humor dynamics
    Emilio Syriani
    Department of Physiological Sciences, School of Medicine, University of Barcelona, Barcelona, Spain
    Invest Ophthalmol Vis Sci 50:3833-9. 2009
    ..Here the authors investigate the role of platelet-derived growth factor (PDGF), a known activator of the Rac1 pathway, in cell cytoskeleton, outflow facility, and intraocular pressure (IOP)...
  40. pmc The platelet-derived growth factor signaling system in snapping turtle embryos, Chelydra serpentina: potential role in temperature-dependent sex determination and testis development
    Turk Rhen
    Department of Biology, Box 9019, University of North Dakota, Grand Forks, ND 58202, USA
    Gen Comp Endocrinol 161:335-43. 2009
    ..Together, these findings demonstrate that temperature has tissue specific effects on the Pdgf system and suggest that Pdgf signaling is involved in sex determination and the ensuing differentiation of testes in the snapping turtle...
  41. ncbi Platelet-derived growth factor-A mRNA expression in fetal, normal adult, and atherosclerotic human aortas. Analysis by competitive polymerase chain reaction
    C E Murry
    Department of Pathology, University of Washington, School of Medicine, Seattle, WA 98195, USA
    Circulation 93:1095-106. 1996
    ..We tested whether platelet-derived growth factor-A (PDGF-A) mRNA levels correlated with cell proliferation in developing aorta, normal adult aorta, and atherosclerotic plaques...
  42. ncbi GC factor 2 represses platelet-derived growth factor A-chain gene transcription and is itself induced by arterial injury
    L M Khachigian
    Centre for Thrombosis and Vascular Research, The University of New South Wales, Department of Haematology, Prince of Wales Hospital, Sydney, Australia
    Circ Res 84:1258-67. 1999
    ..The genes encoding PDGF A chain (PDGF-A) and PDGF B chain (PDGF-B) reside on separate chromosomes and are independently regulated at the level ..
  43. ncbi Characterization and expression of three forms of cDNA encoding chicken platelet-derived growth factor-A chain
    H Horiuchi
    Department of Immunobiology, Faculty of Applied Biological Science, Hiroshima University, Kagamiyama, Higashi Hiroshima 739 8528, Japan
    Gene 272:181-90. 2001
    ..These results suggest that chicken PDGF in thrombocytes plays an important role in the vascular system and in healing damaged tissue...
  44. ncbi Effect of platelet-derived growth factor isoforms in rat metanephric mesenchymal cells
    Jill M Ricono
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Am J Physiol Renal Physiol 282:F211-9. 2002
    ..To explore potential mechanisms for failure of PDGF A-chain to rescue mesangial cell phenotype, we investigated the biological effects and signaling pathways of PDGF AA ..
  45. pmc Expression of platelet derived growth factor B chain and beta receptor in human coronary arteries after percutaneous transluminal coronary angioplasty: an immunohistochemical study
    S Tanizawa
    Department of Cardiovascular Pathology, University of Amsterdam, Netherlands
    Heart 75:549-56. 1996
    ..To evaluate whether expression of platelet derived growth factor B (PDGF-B) protein is associated with expression of its receptor protein in human coronary arteries after angioplasty and to identify cells involved...
  46. ncbi Platelet-derived growth factor inhibits platelet activation in heparinized whole blood
    F Selheim
    Department of Biochemistry and Molecular Biology, University of Bergen, Norway
    Thromb Res 95:185-96. 1999
    ..Our results demonstrate that platelet-derived growth factor appears to be a true antithrombotic agent only under aggregating conditions in heparinized whole blood...
  47. doi Platelet-derived growth factor expression and function in idiopathic pulmonary arterial hypertension
    Frederic Perros
    Centre National de Référence de l Hypertension Artérielle Pulmonaire, Service de Pneumologie et Reanimation Respiratoire, Institut Paris Sud Cytokines, Hopital Antoine Beclere, Universite Paris Sud 11, UPRES EA 2705, Clamart, France
    Am J Respir Crit Care Med 178:81-8. 2008
    ....
  48. ncbi Role of long-form PDGF A-chain in the growth of vascular smooth muscle cells from spontaneously hypertensive rats
    N Fukuda
    Second Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan
    Am J Hypertens 10:1117-24. 1997
    ..Two isoforms of PDGF A-chain mRNA that either include (long form) or exclude (short form) exon 6 are produced as a result of alternative ..
  49. ncbi Involvement of growth factors in the process of post-vasectomy micro-recanalization
    Brandon C Stahl
    Department of Urology, University of Iowa, Iowa City, Iowa 52242 1089, USA
    J Urol 179:376-80. 2008
    ....
  50. pmc Oncogene expression in vivo by ovarian adenocarcinomas and mixed-mullerian tumors
    B M Kacinski
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06510
    Yale J Biol Med 62:379-92. 1989
    ..The authors discuss the role that tumor epithelial cell expression of the fms gene product might play in the auto- and paracrine control of growth and dissemination of ovarian adenocarcinomas...
  51. ncbi Differential regulation of ANG2 and VEGF-A in human granulosa lutein cells by choriogonadotropin
    D Pietrowski
    Department of Obstetrics and Gynecology, University of Freiburg, Freiburg, Germany
    Exp Clin Endocrinol Diabetes 112:208-14. 2004
    ..These findings may add impact on the hypothesis of choriogonadotropin as a novel angiogenic factor...
  52. ncbi A potential role for PDGF-C in experimental and clinical proliferative vitreoretinopathy
    Hetian Lei
    The Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 48:2335-42. 2007
    ..In addition, we examined which PDGF isoforms were present in the vitreous of patients with PVR, to assess the relevance of the rabbit model to the clinical setting...
  53. ncbi Promoter haplotype combinations of the platelet-derived growth factor alpha-receptor gene predispose to human neural tube defects
    P H Joosten
    Department of Cell Biology, University of Nijmegen, Nijmegen, The Netherlands
    Nat Genet 27:215-7. 2001
    ..Our data indicate that specific combinations of naturally occurring PDGFRA promoter haplotypes strongly affect NTD genesis...
  54. ncbi Haplotype-dependent binding of nuclear proteins to the promoter of the neural tube defects-associated platelet-derived growth factor alpha-receptor gene
    Mascha Toepoel
    Department of Cell Biology FNWI, Radboud University Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
    Biochim Biophys Acta 1741:350-7. 2005
    ..The current identification of cis-acting elements in the PDGFRA promoter and the transcription factors that bind them, provides a new strategy for the identification of genes that are potentially involved in neural tube defects...
  55. ncbi Modelling large areas of demyelination in the rat reveals the potential and possible limitations of transplanted glial cells for remyelination in the CNS
    W F Blakemore
    Department of Clinical Veterinary Medicine, Cambridge, United Kingdom
    Glia 38:155-68. 2002
    ..Using this approach, we have obtained data that suggest that delaying the time of the interaction between OPCs and demyelinated axons restricts the expression of the remyelinating potential of transplanted OPCs...
  56. ncbi Selective expression of PDGF A and its receptor during early mouse embryogenesis
    M Mercola
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts
    Dev Biol 138:114-22. 1990
    ..RNAse protection analysis shows that PDGF A chain, but not B chain, mRNA is expressed in 6.5- to 8.5-day embryonic and extraembryonic tissues...
  57. doi Platelet-derived growth factor receptor regulates salivary gland morphogenesis via fibroblast growth factor expression
    Shinya Yamamoto
    Division of Oral Health, Growth and Development, Faculty of Dental Science, Kyushu University, Fukuoka 812 8582, Japan
    J Biol Chem 283:23139-49. 2008
    ..In contrast, short interfering RNA for Pdgfa and -b as well as neutralizing antibodies for PDGF-AB and -BB showed decreased branching...
  58. ncbi Restenosis following angioplasty in the swine coronary artery is inhibited by an orally active PDGF-receptor tyrosine kinase inhibitor, RPR101511A
    G Bilder
    Department of Cardiovascular Biology, Medicinal Chemistry, Rhone Poulenc Rorer, Collegeville, PA, USA
    Circulation 99:3292-9. 1999
    ..Because these activities underlie restenosis, inhibition of the PDGF-receptor tyrosine kinase (PDGFr-TK) is postulated to decrease restenosis...
  59. ncbi PDGF C is a selective alpha platelet-derived growth factor receptor agonist that is highly expressed in platelet alpha granules and vascular smooth muscle
    Li Fang
    Millennium Pharmaceuticals, South San Francisco, Calif 94080, USA
    Arterioscler Thromb Vasc Biol 24:787-92. 2004
    The platelet-derived growth factor (PDGF) family consists of four members, PDGF A, PDGF B, and 2 new members, PDGF C and PDGF D, which signal through the alpha and beta PDGF receptor (PDGFR) tyrosine kinases...
  60. pmc Endothelial cell hyperplasia in human glioblastoma: coexpression of mRNA for platelet-derived growth factor (PDGF) B chain and PDGF receptor suggests autocrine growth stimulation
    M Hermansson
    Ludwig Institute for Cancer Research, Uppsala Branch, University Hospital, Sweden
    Proc Natl Acad Sci U S A 85:7748-52. 1988
    ..cells contained large quantities of mRNA for PDGF B chain/c-sis and its receptor and, to a lesser extent, for PDGF A chain. In contrast, the tumor cells expressed more mRNA for PDGF A chain than for PDGF B chain and PDGF receptor...
  61. ncbi Developmentally regulated expression of two novel platelet-derived growth factor alpha-receptor transcripts in human teratocarcinoma cells
    S Mosselman
    Department of Cell Biology, University of Nijmegen, The Netherlands
    Cancer Res 54:220-5. 1994
    ..Expression of PDGF alpha-receptor transcripts containing the cryptic exon may be useful as a marker for undifferentiated stem cells in human teratocarcinomas...
  62. ncbi Content and activity of cAMP response element-binding protein regulate platelet-derived growth factor receptor-alpha content in vascular smooth muscles
    Peter A Watson
    Denver Research Institute, Denver Veterans Affairs Medical Center, University of Colorado Health Sciences Center, 1055 Clermont Street, Denver, CO 80220, USA
    Endocrinology 143:2922-9. 2002
    ..Thus, both in vitro and in vivo loss of CREB content and activity and subsequent accumulation of PDGFRalpha may contribute to SMC activation during diabetes...
  63. ncbi Regulation and role of PDGF receptor alpha-subunit expression during embryogenesis
    G C Schatteman
    Department of Pathology, University of Washington, Seattle 98195
    Development 115:123-31. 1992
    ..factor receptor alpha-subunit (PDGFR alpha) is the form of the PDGF receptor that is required for binding of PDGF A-chain...
  64. ncbi Altered development of spinal cord in the mouse mutant (Patch) lacking the PDGF receptor alpha-subunit gene
    L Li
    Department of Neurobiology and Anatomy, Bowman Gray School of Medicine, Wake Forest University, Winston Salem, NC 27157, USA
    Brain Res Dev Brain Res 96:204-9. 1996
    ....
  65. ncbi Lens-specific expression of PDGF-A alters lens growth and development
    L W Reneker
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas, 77030, USA
    Dev Biol 180:554-65. 1996
    ..Elevated levels of PDGF-A enhance proliferation, but also appear to induce some aspects of the fiber cell differentiation pathway...
  66. ncbi Exogenous PDGF-D is a potent mesangial cell mitogen and causes a severe mesangial proliferative glomerulopathy
    Kelly L Hudkins
    University of Washington, Seattle, Washington 98195, USA
    J Am Soc Nephrol 15:286-98. 2004
    ..Finally, this approach has resulted in a unique and potentially valuable model of mesangial proliferative glomerulopathy and its resolution...
  67. doi PDGF receptor beta is a potent regulator of mesenchymal stromal cell function
    Ayano Tokunaga
    Department of Pathology, University of Toyama, Toyama, Japan
    J Bone Miner Res 23:1519-28. 2008
    ..The effects of PDGFRalpha on the osteogenic differentiation were very subtle. PDGFRbeta could represent an important target for guided tissue regeneration or tissue engineering of bone...
  68. doi Interaction of PDGFRA promoter haplotypes and maternal environmental exposures in the risk of spina bifida
    Mascha Toepoel
    Department of Cell Biology, Radboud University Nijmegen, Nijmegen 6525 AJ, The Netherlands
    Birth Defects Res A Clin Mol Teratol 85:629-36. 2009
    ..Aberrant expression of the platelet-derived growth factor alpha-receptor (PDGFRA) gene has been implicated in neural-tube-defect etiology in both mice and humans...
  69. ncbi A human YAC transgene rescues craniofacial and neural tube development in PDGFRalpha knockout mice and uncovers a role for PDGFRalpha in prenatal lung growth
    T Sun
    Wolfson Institute for Biomedical Research and Department of Biology, The Cruciform Building, University College London, Gower Street, London WC1E 6BT, UK
    Development 127:4519-29. 2000
    ..In addition, we found that the YAC transgene did not prolong survival of Patch mutant mice, indicating that genetic defects outside the PDGFRalpha locus contribute to the early embryonic lethality of Patch mice...
  70. ncbi Human mesothelioma cells and asbestos-exposed mesothelial cells are selectively resistant to amosite toxicity: a possible mechanism for tumor promotion by asbestos
    E W Gabrielson
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    Carcinogenesis 13:1359-63. 1992
    ..SV40 immortalized cells that have become tumorigenic after transfection with either Ha-ras or PDGF A-chain genes were not significantly more resistant to the cytotoxic effects of amosite than primary normal cells, ..
  71. ncbi PDGF-A and PDGFR-alpha regulate tooth formation via autocrine mechanism during mandibular morphogenesis in vitro
    Y Chai
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles 90033, USA
    Dev Dyn 213:500-11. 1998
    ..These data suggest that PDGF-A and its cognate receptor (PDGFR-alpha) regulate the size and stage of tooth development via an autocrine mechanism during odontogenesis in vitro...
  72. ncbi Abnormal gastrointestinal development in PDGF-A and PDGFR-(alpha) deficient mice implicates a novel mesenchymal structure with putative instructive properties in villus morphogenesis
    L Karlsson
    Department of Medical Biochemistry, Goteborg University, Medicinaregatan 9A, Box 440, SE 405 30 Goteborg, Sweden Linda
    Development 127:3457-66. 2000
    ..The role of PDGF-A seems to be to secure renewal of PDGFR-(alpha) positive cells when they are consumed in the initial rounds of cluster formation...
  73. ncbi Concordant and discordant interleukin-1-mediated signaling in lung fibroblast thy-1 subpopulations
    James S Hagood
    Department of Pediatrics, University of Alabama Birmingham School of Medicine, 35294 0005, USA
    Am J Respir Cell Mol Biol 26:702-8. 2002
    ....
  74. pmc Platelet-derived growth factor-D and Rho GTPases regulate recruitment of cancer-associated fibroblasts in cholangiocarcinoma
    Massimiliano Cadamuro
    Department of Surgery, Oncology and Gastroenterology, University of Padova, Italy
    Hepatology 58:1042-53. 2013
    ..In fibroblasts, PDGF-D activated the Rac1 and Cdc42 Rho GTPases and c-Jun N-terminal kinase (JNK). Selective inhibition of Rho GTPases (particularly Rac1) and of JNK strongly reduced PDGF-D-induced fibroblast migration...
  75. pmc TLR4 Deficiency Impairs Oligodendrocyte Formation in the Injured Spinal Cord
    Jamie S Church
    Neuroscience Graduate Program, Center for Brain and Spinal Cord Repair, and
    J Neurosci 36:6352-64. 2016
    ....
  76. ncbi The v-sis oncogene product but not platelet-derived growth factor (PDGF) A homodimers activate PDGF alpha and beta receptors intracellularly and initiate cellular transformation
    B E Bejcek
    Department of Medicine, Jewish Hospital, Washington University Medical Center, St Louis, Missouri 63110
    J Biol Chem 267:3289-93. 1992
    ..platelet-derived growth factor (PDGF) B chain share 92% homology with each other and over 50% homology with the PDGF A chain. Exogenously added homodimers of PDGF A and PDGF B and of p28v-sis are potent mitogens but only PDGF B and p28v-..
  77. ncbi Developmental distribution of platelet-derived growth factor in the mouse central nervous system
    J B Hutchins
    Department of Anatomy, University of Mississippi Medical Center, Jackson 39216 4505
    Brain Res Dev Brain Res 67:121-35. 1992
    ..b>PDGF A-chain (localized with an antibody to PDGF(AA) dimers) appears to be found in growth cones of developing neurons in ..
  78. ncbi Increased expression of PDGF A- and B-chain genes in rat lungs with hypoxic pulmonary hypertension
    D Katayose
    First Department of Internal Medicine, Tohoku University School of Medicine, Miyagi, Japan
    Am J Physiol 264:L100-6. 1993
    ..of platelet-derived growth factor (PDGF) in the pulmonary vascular remodeling caused by hypoxia, we cloned rat PDGF A- and B-chain cDNA and prepared specific cRNA probes...
  79. ncbi Structural determinants in the platelet-derived growth factor alpha-receptor implicated in modulation of chemotaxis
    K Yokote
    Ludwig Institute for Cancer Research, Box 595, Biomedical Center, S 751 24 Uppsala, Sweden
    J Biol Chem 271:5101-11. 1996
    ..Thus our data indicate that the PDGF alpha-receptor has an intrinsic ability to transduce a chemotactic signal, and that this signal is counteracted by overriding negative signals...
  80. ncbi The nature of acute rejection is associated with development of graft vascular disease after clinical heart transplantation
    C C Baan
    Department of Internal Medicine 1, University Hospital Rotterdam Dijkzigt, Rotterdam, The Netherlands
    J Heart Lung Transplant 17:363-73. 1998
    ..To determine mechanisms that trigger graft vascular disease (GVD) after heart transplantation, we studied parameters that reflect both early and late intragraft allogeneic reactions...
  81. ncbi Diminished matrix metalloproteinase 2 (MMP-2) in ectomesenchyme-derived tissues of the Patch mutant mouse: regulation of MMP-2 by PDGF and effects on mesenchymal cell migration
    J R Robbins
    Department of Cell Biology and Physiology, University of New Mexico School of Medicine, 149 Basic Medical Sciences Building, Albuquerque, New Mexico, 87131, USA
    Dev Biol 212:255-63. 1999
    ....
  82. ncbi Intragraft platelet-derived growth factor-alpha and transforming growth factor-beta1 during the development of accelerated graft vascular disease after clinical heart transplantation
    H A de Groot-Kruseman
    Department of Internal Medicine I, University Hospital Rotterdam Dijkzigt, Rotterdam, The Netherlands
    Transpl Immunol 7:201-5. 1999
    ..These results suggest that intragraft PDGF-alpha and TGF-beta1 play a role in the pathogenesis of accelerated GVD after clinical heart transplantation...
  83. ncbi Density dependent expression of PDGF-A modulates the angiotensin II dependent proliferation of rat cardiac fibroblasts
    A Simm
    Institut für Klinische Biochemie und Pathobiochemie, Wurzburg, Germany
    Basic Res Cardiol 94:464-71. 1999
    ..In summary, we could show that the Ang-II induced cell proliferation in adult cardiac fibroblasts is mainly due to cell density dependent expression of growth factors like PDGF-AA...
  84. pmc Role of platelet-derived growth factor in allograft vasculopathy
    M C Mancini
    Division of Cardiothoracic Surgery, Louisiana State University Health Sciences Center Shreveport, Shreveport, Louisiana 71106, USA
    Ann Surg 231:682-8. 2000
    ..To test the hypothesis that platelet-derived growth factor (PDGF) accelerates the formation of allograft vascular disease...
  85. ncbi Oxidized-LDL and atherosclerosis. Role of LOX-1
    T Kita
    Graduate School of Medicine, Kyoto University, Department of Geriatric Medicine, Japan
    Ann N Y Acad Sci 902:95-100; discussion 100-2. 2000
    ..and T lymphocytes, and growth factors, such as heparin-binding epidermal growth factor-like growth factor and PDGF A and B chains. Recently, we identified the novel receptor for oxidized LDL, named LOX-1...
  86. ncbi Relationship of fiber surface iron and active oxygen species to expression of procollagen, PDGF-A, and TGF-beta(1) in tracheal explants exposed to amosite asbestos
    J Dai
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Respir Cell Mol Biol 24:427-35. 2001
    ..Surface iron and AOS also play a role in PDGF-A and TGF-beta gene expression, but through an ERK-dependent mechanism...
  87. ncbi Oxidative stress and increased expression of growth factors in lesions of failed hemodialysis access
    M F Weiss
    Department of Medicine, Division of Nephrology, University Hospitals of Cleveland, OH 44106, USA
    Am J Kidney Dis 37:970-80. 2001
    ..ET-1 staining was most intense in the neointima and pseudointima. This study showed histochemical colocalization of markers of oxidative stress with growth factors known to contribute to intimal hyperplasia...
  88. ncbi Chemotactic factors enhance myogenic cell migration across an endothelial monolayer
    S Corti
    Centro Dino Ferrari, Istituto di Clinica Neurologica, Università di Milano IRCCS, Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy
    Exp Cell Res 268:36-44. 2001
    ..We consider that any new report elucidating the molecular signals involved in myoblast migration may be useful toward the development of systemic cellular-mediated gene therapy of muscle diseases...
  89. ncbi Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease
    T J MacDonald
    Center for Cancer and Transplantation Biology, Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC, USA
    Nat Genet 29:143-52. 2001
    ..Using in vitro assays, we show that platelet-derived growth factor alpha (PDGFA) enhances medulloblastoma migration and increases downstream MAP2K1 (MEK1), MAP2K2 (MEK2), MAPK1 (p42 MAPK) and ..
  90. ncbi Mechanisms by which high-dose estrogen therapy produces anabolic skeletal effects in postmenopausal women: role of locally produced growth factors
    S Bord
    University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
    Bone 29:216-22. 2001
    ....
  91. ncbi Proliferative and morphological effects of endothelins in Schwann cells: roles of p38 mitogen-activated protein kinase and Ca(2+)-independent phospholipase A2
    L N Berti-Mattera
    Division of Hypertension, Department of Medicine, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, Ohio 44106 4982, USA
    J Neurochem 79:1136-48. 2001
    ..The unique pattern of signaling pathways recruited by ET-1 and its combined effects on regulation of phenotype and proliferation of SC suggest an important role for this peptide during nerve degeneration/regeneration...
  92. ncbi PDGF-A/PDGF alpha-receptor signaling is required for lung growth and the formation of alveoli but not for early lung branching morphogenesis
    Hans Bostrom
    Department of Medical Biochemistry, Goteborg University, Goteborg, Sweden
    Dev Dyn 223:155-62. 2002
    ..We conclude that, although PDGF-AA signaling over PDGFR alpha may have direct or indirect roles in overall lung growth, it does not specifically control early branching of the lung epithelium...
  93. ncbi Growth factor upregulation during obliterative bronchiolitis in the mouse model
    Robert M Aris
    Division of Pulmonary Medicine, Department of Medicine, 420 Burnett Womack Building, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7524, USA
    Am J Respir Crit Care Med 166:417-22. 2002
    ..037) in this model. We conclude that increased expression of a large number of growth factors occurs during OB in this model. Growth factor blockade (in particular with regard to TNF-alpha) may be useful in ameliorating OB in this model...
  94. ncbi Connective tissue growth factor and its correlation to other growth factors in experimental granulation tissue
    Kaija Inkinen
    Fourth Department of Surgery, Haartman Institute, University of Helsinki, Helsinki, Finland
    Connect Tissue Res 44:19-29. 2003
    ..b>PDGF A and PDGF B mRNA expressions were at maximum on day 14 and on day 21, respectively...
  95. ncbi Ets-1 stimulates platelet-derived growth factor A-chain gene transcription and vascular smooth muscle cell growth via cooperative interactions with Sp1
    Fernando S Santiago
    Centre for Vascular Research, The University of New South Wales, and the Department of Haematology, The Prince of Wales Hospital, Sydney, Australia
    Circ Res 95:479-87. 2004
    ..These findings identify a functional cis-acting element for Ets-1 in the PDGF-A promoter and demonstrate that Sp1 and Ets-1 cooperatively activate PDGF-A transcription in vascular SMCs...
  96. ncbi The phosphoinositol 3,4-bisphosphate-binding protein TAPP1 interacts with syntrophins and regulates actin cytoskeletal organization
    Angela Hogan
    Department of Cellular and Molecular Medicine, Centre for Neuromuscular Disease, University of Ottawa, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada
    J Biol Chem 279:53717-24. 2004
    ..Collectively, our results suggest syntrophins regulate the localization of TAPP1, which may be important for remodeling the actin cytoskeleton in response to growth factor stimulation...
  97. ncbi Puralpha activates PDGF-A gene transcription via interactions with a G-rich, single-stranded region of the promoter
    Qingbei Zhang
    Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Gene 348:25-32. 2005
    ..These results indicate Puralpha enhances transcription of the PDGF-A gene through its interactions with single-stranded, G-rich strands in the promoter, perhaps by stabilizing non-B-form DNA conformations...
  98. ncbi Paneling human thyroid cancer cell lines for candidate proteins for targeted anti-angiogenic therapy
    Sebastian Hoffmann
    Department of Surgery, Philipps University of Marburg, Baldingerstrasse, D 35039 Marburg, Germany
    J Cell Biochem 98:954-65. 2006
    ..For the first time, angiostatin, endostatin, and possibly also aaATIII are identified as novel candidate regulators of angiogenesis in thyroid carcinoma cells...
  99. ncbi Molecular correlates of imatinib resistance in gastrointestinal stromal tumors
    Michael C Heinrich
    Division of Hematology Oncology, Department of Pathology, Oregon Health and Science University Cancer Institute, Oregon Health and Science University, Portland, OR, USA
    J Clin Oncol 24:4764-74. 2006
    ..In clinical studies, 75% to 90% of patients with advanced GISTs experience clinical benefit from imatinib. However, imatinib resistance is an increasing clinical problem...
  100. doi Toll-like receptor 4 ligand can differentially modulate the release of cytokines by human platelets
    Fabrice Cognasse
    EFS Auvergne Loire, Saint Etienne, France
    Br J Haematol 141:84-91. 2008
    ..We propose that platelets adapt the subsequent responses, with polarized cytokine secretion, after TLR4 involvement...
  101. doi Combined anti-PDGFRalpha and PDGFRbeta targeting in non-small cell lung cancer
    Niels Reinmuth
    Department of Medicine Hematology and Oncology and the IZKF Muenster, University of Muenster, Muenster, Germany
    Int J Cancer 124:1535-44. 2009
    ..These studies demonstrate that combined inhibition of PDGFRalpha and -beta results in markedly decreased tumor growth in vivo because of impaired recruitment of periendothelial cells...

Research Grants49

  1. Harish Vasudevan; Fiscal Year: 2015
    ..In mice, loss of PDGF Receptor [unreadable] (PDGFR[unreadable]) or its ligands, PDGFA and PDGFC, results in facial clefting...
  2. Dysregulation of the Tumor Microenvironment in Hepatocellular Carcinoma
    Lewis R Roberts; Fiscal Year: 2010
    ..This study will investigate the function of recently discovered sulfatase enzymes that enhance growth of liver cancers, with the goal of developing effective treatments for this devastating disease. ..
  3. UNIQUE GLIAL CELL POPULATION IN THE BRAIN
    Akiko Nishiyama; Fiscal Year: 1999
    ..The presence of a physical interaction between NG2 and PDGF a receptor has been demonstrated by bioclleluical rllelhoils...
  4. PLATELET AND CELL GROWTH--ROLE OF PDGF
    THOMAS DEUEL; Fiscal Year: 2002
    ..We aim to analyze the effects of gain of function of PDGF A, of pleiotrophin, and the loss of function pleiotrophin dominant negative effector PTN 1-40 in the vascular system ..
  5. Stephen E McGowan; Fiscal Year: 2016
    ..These studies are relevant to other vascular diseases including stroke, diabetes, and chronic renal insufficiency, which are also common among veterans. ..
  6. BASIS OF PAX3-FKHR ONCOGENESIS IN RHABDOMYOSARCOMA
    Chiayeng Wang; Fiscal Year: 2001
    ..The third aim is to examine how PDGFaR function contributes to ARMS tumor cell growth. Since PDGF is a potent mitotic growth factor, aberrant expression of its receptor is likely to play a crucial role in cell transformation. ..
  7. PDGF SIGNALING IN OLIGODENDROCYTE DEVELOPMENT
    RANDALL MCKINNON; Fiscal Year: 2004
    ..abstract_text> ..
  8. DOMINANT NEGATIVE PDGF RECEPTORS IN AIRWAY FIBROSIS
    Melissa King; Fiscal Year: 2000
    ....
  9. Mechanisms of Pulmonary Vein Development
    Steven B Bleyl; Fiscal Year: 2010
    ..My data in chick show that Pdgfra and its ligand Pdgfa are expressed in mesenchyme on opposite sides of the heart stalk during PV formation and later around the PV as it ..
  10. PHILIPPE M SORIANO; Fiscal Year: 2016
    ..Loss of the PDGFRa or of its ligands PDGFA and PDGFC lead to facial clefting and improper development of the frontonasal process, whereas hypomorphic ..
  11. RESISTANCE ARTERY REMODELING HYPERTENSION
    Russell Prewitt; Fiscal Year: 2005
    ..This information could also form the basis for more effective therapy to reverse structural changes in arterial walls that if unchecked can lead to vascular pathologies in target organs. ..
  12. PULMONARY FIBROSIS IN PDGF TRANSGENIC MICE
    Gary Hoyle; Fiscal Year: 2000
    ..The SPC promoter will be used to overexpress genes encoding the PDGF A and PDGF B genes singly and in combination to assess the potential of PDGF isoforms to initiate pulmonary fibrosis ..
  13. Targets of Ewing Sarcoma-Wilms Tumor 1 Oncoprotein
    Daniel Haber; Fiscal Year: 2006
    ..abstract_text> ..
  14. GROWTH FACTORS EFFECT ON ASPECTS OF BONE FORMATION
    Ernesto Canalis; Fiscal Year: 2001
    ..Recently, we found that osteoblast enriched (Ob) cells from 22-day fetal rat calvariae express mRNA encoding the PDGF A, and not the @PDGF B polypeptide, but the regulation of skeletal PDGF A synthesis has not been examined...
  15. SRY GENE REGULATION AND YP LOSS IN PROSTATE CARCINOMA
    JAMES TRICOLI; Fiscal Year: 1999
    ..These include the hormones testosterone, dihydrotestosterone and estradiol and the growth factors of FGF-beta, PDGFa, TGF-beta and EGF. Finally, Dr...
  16. ANGIOTENSIN II INDUCTION OF PDGF SMOOTH MUSCLE CELLS
    Allen Naftilan; Fiscal Year: 1993
    ..This current proposal will examine in detail the molecular mechanisms by which ang II increases the PDGF A-chain mRNA and will also attempt to define the significance of this increase...
  17. DERMAL-EPIDERMAL INTERACTIONS IN DIABETIC WOUND HEALING
    Timothy Crombleholme; Fiscal Year: 2004
    ..abstract_text> ..
  18. GENESIS OF PULMONARY HYPERTENSION
    Barbara Cahill; Fiscal Year: 2000
    ..My goal with this project is to acquire the skills and knowledge required to become and independent investigator and advance my career as an academic physician. ..
  19. VIRAL TROPISM IN VASCULAR AGING--ROLE OF FGF RECEPTOR
    DAVID HAJJAR; Fiscal Year: 1992
    ..Experiments are designed to assess the effect of HSV on 1) PDGF production by EC and SMC 2) PDGF A and B chain mRNA transcript levels; 3) PDGF isoforms...
  20. ENDOTHELIAL INJURY IN SMALL VESSELS
    Stephen Schwartz; Fiscal Year: 2003
    ..Finally, these same questions may be relevant to the proliferative responses seen in hypertensive microvasculature. We have developed a new model for this response and propose to extend our efforts to the microvascular level. ..
  21. AGE EFFECTS ON ARTERIAL CELL FUNCTION IN ATHEROSCLEROSIS
    Babette Weksler; Fiscal Year: 1992
    ..level, with special attention directed at the abnormal expression of autrocrine growth factor genes (c- sis and PDGF A-chain)...
  22. DEVELOPMENT OF AN ASSAY FOR SCREENING PDGF ANTAGONISTS
    James Tomlinson; Fiscal Year: 1991
    ..At this point large chemical libraries will be intensively screened to identify compounds with therapeutic potential for the treatment of vascular restenosis...
  23. SCOR IN MOLECULAR MEDICINE AND ATHEROSCLEROSIS
    Lewis Cantley; Fiscal Year: 2001
    ....
  24. TRANSCRIPTIONAL REGULATION OF PDGF BY ENDOTHELIUM
    Mark Fleming; Fiscal Year: 2007
    ..Exploring the structure of the PDGF A- and B-chain genes and their transcriptional regulation by endothelial cells has been a focus of this laboratory ..
  25. GROWTH FACTOR REGULATION OF P27KIPL EXPRESSION
    W Pledger; Fiscal Year: 2000
    ..The final aim will examine the mechanism through which multiple growth factor signals collaborate to bring about p27 degradation in mid to late G1 and identify the elements that target p27 to this degradative pathway. ..
  26. HEMOPOIETIC ENVIRONMENT OF RETROVIRAL INFECTED MARROW
    Michael Linenberger; Fiscal Year: 1993
    ....
  27. FIBROBLAST CD 90 EXPRESSION IN FIBROGENIC SKIN DISORDERS
    James Hagood; Fiscal Year: 2002
    ..Establishing the role of fibroblast Thy-1/CD90 expression in human fibrogenic skin diseases is likely to unlock mechanisms of fibroblast activation and lead to more effective treatments for fibrotic disorders in skin and other tissues. ..
  28. Effects of intracellular angiotensin II
    Julia Cook; Fiscal Year: 2009
    ..and that the growth stimulation is accompanied by cAMP response element-binding protein (CREB) phosphorylation and PDGF A-chain upregulation...
  29. CHRONIC LUNG INJURY AFTER PREMATURE BIRTH
    Richard Bland; Fiscal Year: 2003
    ....
  30. Mechanism of endothelial cell damage in scleroderma
    Maria Trojanowska; Fiscal Year: 2004
    ..These studies may help us to unravel the molecular basis of the disease and ultimately provide the logical target for therapeutic intervention. ..
  31. Systemic perinatal insults disrupt neurodevelopment
    Shenandoah Robinson; Fiscal Year: 2008
    ..Insights into mechanisms underlying the disruption of perinatal neural development will lead to novel interventions to enhance neural development in neonates, and minimize neurologic deficits. ..
  32. ESTROGEN METABOLITES EFFECTS ON BONE
    Russell Turner; Fiscal Year: 2002
    ..abstract_text> ..
  33. Oxidative Stress and Hemodialysis Access Failure
    MIRIAM WEISS; Fiscal Year: 2002
    ..Specific Aim C: To compare the success rates of prophylactic angioplasty when non-invasive techniques demonstrate decreased flow in the hemodialysis access in alpha-tocopherol-treated versus placebo-treated patients. ..
  34. RETINOIC ACID RECEPTORS AND ALVEOLAR FORMATION
    JEANNE SNYDER; Fiscal Year: 2002
    ..This knowledge will form the foundation for the rational development of agents that promote alveolar growth and repair in humans. ..
  35. PDGF GENE REGULATION BY VITAMINS A & D IN ALVEOLIZATION
    DAVID KAETZEL; Fiscal Year: 2003
    ....
  36. Molecular Mechanisms of Metastasis Suppression by NM23
    David M Kaetzel; Fiscal Year: 2010
    ....
  37. A Novel Mechanism for Intra-articular Nonunion
    Martha M Murray; Fiscal Year: 2010
    ....
  38. PROTEOMIC MAPPING OF MYELIN AND ITS MEMBRANE SUBDOMAINS
    Rashmi Bansal; Fiscal Year: 2009
    ....
  39. THE ROLE OF INSULIN IN HUMAN FETAL LUNG DEVELOPMENT
    JEANNE SNYDER; Fiscal Year: 2004
    ....
  40. Therapeutic Strategies for Environmental Lung Diseases
    James Bonner; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  41. CARDIAC GRAFTS--SKELETAL MYOBLASTS
    CHARLES MURRY; Fiscal Year: 2005
    ....
  42. Enhanced Primary Repair of Ligament Injuries
    Martha Murray; Fiscal Year: 2008
    ..In the third aim, the optimized scaffolds will be tested in an in vivo canine ACL non-union model. Information gained in each of these aims will serve to improve our understanding of mechanisms of ligament healing. ..
  43. VEGF and Nitric Oxide in Lung Vascular Development
    Vivek Balasubramaniam; Fiscal Year: 2007
    ..In addition, Dr. Balasubramaniam will continue to work with Dr. Charles Plopper (UC Davis) to learn more sophisticated techniques of morphometric analysis. ..
  44. Nociception in Diabetic Neuropathy: Role of Endothelins
    Liliana Berti Mattera; Fiscal Year: 2004
    ..abstract_text> ..
  45. Regulation- Medulloblastoma Growth by alpha-v integrins
    Tobey Macdonald; Fiscal Year: 2006
    ..The long-range goal of this work is to broaden our understanding of medulloblastoma growth, so that novel biologic therapies may be developed into new treatments for medulloblastoma, the most common malignant brain tumor in children. ..
  46. DOSE RESPONSE EFFECTS OF ALCOHOL ON BONE METABOLISM
    Russell Turner; Fiscal Year: 2006
    ....
  47. TNFR:Fc Gene Transfer for Treatment of Periodontitis
    William Giannobile; Fiscal Year: 2006
    ..The use of AAV-TNF: Fc has significant potential as a therapeutic regimen to treat aggressive periodontitis that is governed by an exuberant inflammatory response. ..
  48. Comparative Genomics of Sex Determination in Amniotes
    Turk Rhen; Fiscal Year: 2006
    ..This approach promises to speed the rate of discovery of sex-determining genes in humans, which to date has been slow and haphazard. ..
  49. Etiology and Treatment of Parathyroid Bone Disease
    Russell Turner; Fiscal Year: 2005
    ..Since PDGF antagonists such as trapidil are available for human use, positive results could be quickly extended to clinical practice. ..

Patents4

  1. Recombinant platelet-derived growth factor A-chain derived from endothelial cells
    Patent Number: EP0366816-A1; Date:1990-05-09
  2. MULTICISTRONIC EXPRESSION UNITS AND THEIR USE
    Patent Number: WO9405785-A1; Date:1994-03-17
  3. PRODUCTION OF HETERODIMER PDGF-AB BY MEANS OF A BICISTRONIC VECTOR SYSTEM IN MAMMALIAN CELLS
    Patent Number: WO9405786-A1; Date:1994-03-17
  4. MULTICISTRONIC EXPRESSION OF RECOMBINANT GENES IN BACTERIAL CELLS
    Patent Number: WO9429462-A1; Date:1994-12-22