PDE11A

Summary

Gene Symbol: PDE11A
Description: phosphodiesterase 11A
Alias: PPNAD2, dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A, cAMP and cGMP cyclic nucleotide phosphodiesterase 11A
Species: human

Top Publications

  1. ncbi Phosphodiesterase 11 (PDE11) regulation of spermatozoa physiology
    C Wayman
    Discovery Biology, Pfizer Global Research and Development, Sandwich, Kent, UK
    Int J Impot Res 17:216-23. 2005
  2. pmc Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A
    L Fawcett
    Discovery Biology, Pfizer Central Research, Sandwich, Kent CT13 9NJ, United Kingdom
    Proc Natl Acad Sci U S A 97:3702-7. 2000
  3. ncbi Isolation and characterization of two novel phosphodiesterase PDE11A variants showing unique structure and tissue-specific expression
    K Yuasa
    Discovery Research Laboratory, Tanabe Seiyaku Co Ltd, 2 50, Kawagishi 2 chome, Toda, Saitama 335 8505, Japan
    J Biol Chem 275:31469-79. 2000
  4. ncbi Genomic organization of the human phosphodiesterase PDE11A gene. Evolutionary relatedness with other PDEs containing GAF domains
    K Yuasa
    Discovery Research Laboratory, Tanabe Seiyaku Co Ltd, Toda, Saitama, Japan
    Eur J Biochem 268:168-78. 2001
  5. ncbi Variants in PDE11A and PDE1A are not associated with citalopram response
    K S Teranishi
    Mol Psychiatry 12:1061-3. 2007
  6. ncbi Adrenal hyperplasia and adenomas are associated with inhibition of phosphodiesterase 11A in carriers of PDE11A sequence variants that are frequent in the population
    Anelia Horvath
    Section on Endocrinology and Genetics, Developmental Endocrinology Branch, National Institute of Child Health and Human Resources, NIH, Bethesda, MD 20892, USA
    Cancer Res 66:11571-5. 2006
  7. pmc Phosphodiesterase genes are associated with susceptibility to major depression and antidepressant treatment response
    Ma Li Wong
    Center on Pharmacogenomics, Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Proc Natl Acad Sci U S A 103:15124-9. 2006
  8. ncbi A genome-wide scan identifies mutations in the gene encoding phosphodiesterase 11A4 (PDE11A) in individuals with adrenocortical hyperplasia
    Anelia Horvath
    Section on Endocrinology and Genetics, Developmental Endocrinology Branch, US National Institute of Child Health and Human Development, US National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 38:794-800. 2006
  9. pmc Cloning and characterization of two splice variants of human phosphodiesterase 11A
    J M Hetman
    Department of Pharmacology, University of Washington School of Medicine, Box 357280, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 97:12891-5. 2000
  10. pmc PDE11A negatively regulates lithium responsivity
    G Pathak
    Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, Columbia, SC, USA
    Mol Psychiatry . 2016

Research Grants

  1. John R Kelsoe; Fiscal Year: 2015
  2. John R Kelsoe; Fiscal Year: 2014
  3. CNS transcription modulation in peripheral inflammation
    Ma Li Wong; Fiscal Year: 2002
  4. Depression/Metabolic Syndrome in Mexican-American Women.
    Ma Li Wong; Fiscal Year: 2006
  5. Pharmacogenetics of Antidepressant Drugs
    Ma Li Wong; Fiscal Year: 2007

Scientific Experts

  • Maria Alevizaki
  • Anelia Horvath
  • Fabio R Faucz
  • Michy P Kelly
  • C A Stratakis
  • Y K Park
  • Tonny S Petersen
  • George T Kedia
  • Mark H Greene
  • J A Carney
  • Gonzalo Laje
  • S H Francis
  • Mikael Ahlstrom
  • Lars S Kruse
  • C Wayman
  • Ma Li Wong
  • K Loughney
  • John R Kelsoe
  • Jerome Bertherat
  • Rossella Libe
  • Madson Q Almeida
  • Shweta Hegde
  • Nermin S Ahmed
  • Christian P Kratz
  • Maria Nesterova
  • Bruno Ragazzon
  • Lisa Mirabello
  • Marco Gross-Langenhoff
  • Delphine Vezzosi
  • K Yuasa
  • Isaac Levy
  • Lionel Groussin
  • G Pathak
  • Therese Ohlsson
  • Neema S Patel
  • Annick Bergeron
  • Leticia Ferro Leal
  • F Ahmad
  • Anand Pathak
  • Jia Yang Lu
  • Ludivine Drougat
  • E Szarek
  • Paraskevi Xekouki
  • Monalisa F Azevedo
  • H Coon
  • Didem Demirbas
  • Rodrigo Bertollo de Alexandre
  • Dong Ding
  • Ko Un Park
  • Gary A Piazza
  • Bernard D Gary
  • Ashraf H Abadi
  • S Uckert
  • Eric Clauser
  • Maria Yaneva
  • Estelle Louiset
  • Roy H Perlis
  • Fernande Rene-Corail
  • Amato Fratticci
  • Marie Laure Raffin-Sanson
  • Xavier Bertagna
  • Joel Coste
  • Eirini I Bimpaki
  • Hui Pin Hsiao
  • Michael Cabanero
  • Karina Matthiesen
  • E Peverelli
  • Huai Rong Luo
  • Isabelle Bourdeau
  • S A Boikos
  • Deena Waddleton
  • Mimi Tadjine
  • Anita Schultz
  • K S Teranishi
  • Joachim E Schultz
  • James L Weeks
  • K Omori
  • Laure Cazabat
  • J L Weeks
  • Allen D Seftel
  • Michael R D'Andrea
  • J A Beavo
  • Will R Capell
  • S Hegde
  • Nicolas Poupore
  • M J Agostino
  • J L Fisher
  • K Bishara
  • W R Capell
  • Alexander T Sougiannis

Detail Information

Publications77

  1. ncbi Phosphodiesterase 11 (PDE11) regulation of spermatozoa physiology
    C Wayman
    Discovery Biology, Pfizer Global Research and Development, Sandwich, Kent, UK
    Int J Impot Res 17:216-23. 2005
    ..These data are consistent with human data and suggest a role for PDE11 in spermatogenesis and fertilization potential. This is the first phenotype described for the PDE11-/- mouse and the first report of a physiological role for PDE11...
  2. pmc Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A
    L Fawcett
    Discovery Biology, Pfizer Central Research, Sandwich, Kent CT13 9NJ, United Kingdom
    Proc Natl Acad Sci U S A 97:3702-7. 2000
    ..b>PDE11A exhibits </=50% amino acid identity with the catalytic domains of all other PDEs, being most similar to PDE5, ..
  3. ncbi Isolation and characterization of two novel phosphodiesterase PDE11A variants showing unique structure and tissue-specific expression
    K Yuasa
    Discovery Research Laboratory, Tanabe Seiyaku Co Ltd, 2 50, Kawagishi 2 chome, Toda, Saitama 335 8505, Japan
    J Biol Chem 275:31469-79. 2000
    cDNAs encoding a novel phosphodiesterase, phosphodiesterase 11A (PDE11A), were isolated by a combination of reverse transcriptase-polymerase chain reaction using degenerate oligonucleotide primers and rapid amplification of cDNA ends...
  4. ncbi Genomic organization of the human phosphodiesterase PDE11A gene. Evolutionary relatedness with other PDEs containing GAF domains
    K Yuasa
    Discovery Research Laboratory, Tanabe Seiyaku Co Ltd, Toda, Saitama, Japan
    Eur J Biochem 268:168-78. 2001
    b>PDE11A is a dual-substrate, cAMP and cGMP, cyclic nucleotide phosphodiesterase (PDE). Presently four unique variants carrying distinct GAF sequences in the N-terminal region have been identified...
  5. ncbi Variants in PDE11A and PDE1A are not associated with citalopram response
    K S Teranishi
    Mol Psychiatry 12:1061-3. 2007
  6. ncbi Adrenal hyperplasia and adenomas are associated with inhibition of phosphodiesterase 11A in carriers of PDE11A sequence variants that are frequent in the population
    Anelia Horvath
    Section on Endocrinology and Genetics, Developmental Endocrinology Branch, National Institute of Child Health and Human Resources, NIH, Bethesda, MD 20892, USA
    Cancer Res 66:11571-5. 2006
    ..adrenocortical hyperplasia who were carriers of inactivating mutations in the 2q-located phosphodiesterase 11A (PDE11A) gene...
  7. pmc Phosphodiesterase genes are associated with susceptibility to major depression and antidepressant treatment response
    Ma Li Wong
    Center on Pharmacogenomics, Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Proc Natl Acad Sci U S A 103:15124-9. 2006
    ..Polymorphisms in PDE9A and PDE11A were found to be associated with the diagnosis of MDD...
  8. ncbi A genome-wide scan identifies mutations in the gene encoding phosphodiesterase 11A4 (PDE11A) in individuals with adrenocortical hyperplasia
    Anelia Horvath
    Section on Endocrinology and Genetics, Developmental Endocrinology Branch, US National Institute of Child Health and Human Development, US National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 38:794-800. 2006
    ..We identified mutations disrupting the expression of the PDE11A isoform-4 gene (PDE11A) in three kindreds...
  9. pmc Cloning and characterization of two splice variants of human phosphodiesterase 11A
    J M Hetman
    Department of Pharmacology, University of Washington School of Medicine, Box 357280, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 97:12891-5. 2000
    Phosphodiesterase 11A (PDE11A) is a recently identified family of cAMP and cGMP hydrolyzing enzymes. Thus far, a single splice variant designated as PDE11A1 has been reported...
  10. pmc PDE11A negatively regulates lithium responsivity
    G Pathak
    Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, Columbia, SC, USA
    Mol Psychiatry . 2016
    Lithium responsivity in patients with bipolar disorder has been genetically associated with Phosphodiesterase 11A (PDE11A), and lithium decreases PDE11A mRNA in induced pluripotent stem cell-derived hippocampal neurons originating from ..
  11. pmc Cyclic nucleotide phosphodiesterases: important signaling modulators and therapeutic targets
    F Ahmad
    Cardiovascular and Pulmonary Branch, National Heart, Lung and Blood Institute, Bethesda, MD, USA
    Oral Dis 21:e25-50. 2015
    ..Alterations in expression of PDEs and PDE-gene mutations (especially mutations in PDE6, PDE8B, PDE11A, and PDE4) have been implicated in various diseases and cancer pathologies...
  12. ncbi Does phosphodiesterase 11A (PDE11A) hold promise as a future therapeutic target?
    Michy P Kelly
    Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, 6439 Garners Ferry Road, VA Bldg 1, 3rd Floor, D 12, Columbia, SC 29208
    Curr Pharm Des 21:389-416. 2015
    Phosphodiesterase 11A (PDE11A) is the most recently discovered 3', 5'-cyclic nucleotide phosphodiesterase. By breaking down both cAMP and cGMP, PDE11A is a critical regulator of intracellular signaling...
  13. doi Phosphodiesterase isoenzymes in the human urethra: a molecular biology and functional study
    George T Kedia
    Hannover Medical School, Division of Surgery, Department of Urology and Urological Oncology, Carl Neuberg Str 1, Hannover 30625, Germany Electronic address
    Eur J Pharmacol 741:330-5. 2014
    ..RT-PCR analysis revealed the expression of PDE1B, PDE1C, PDE4A, PDE4C, PDE4D, PDE5A and PDE11A. The tension induced by norepinephrine (NE) was reversed by the PDE inhibitors with the following rank order of ..
  14. pmc Phosphodiesterases and adrenal Cushing in mice and humans
    E Szarek
    Section of Endocrinology and Genetics, Program on Developmental Endocrinology Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
    Horm Metab Res 46:863-8. 2014
    ..A Genome Wide Association study, in 2006, led to the identification of mutations in 2 PDE genes: PDE8B and PDE11A; mutations in these 2 genes modulate steroidogenesis...
  15. pmc p54nrb/NONO regulates cyclic AMP-dependent glucocorticoid production by modulating phosphodiesterase mRNA splicing and degradation
    Jia Yang Lu
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, USA
    Mol Cell Biol 35:1223-37. 2015
    ..the expression of multiple phosphodiesterase (PDE) isoforms, including PDE2A, PDE3A, PDE3B, PDE4A, PDE4D, and PDE11A, was induced in p54(nrb)/NONO knockdown cells...
  16. doi Phosphodiesterase 8B and cyclic AMP signaling in the adrenal cortex
    Leticia Ferro Leal
    Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics PDEGEN Eunice Kennedy Shriver National Institute of Child Health and Human Development NICHD, National Institutes of Health, 10 Center Drive, Building 10, NIH Clinical Research Center, Room 1 3216, Bethesda, MD, 20892, USA
    Endocrine 50:27-31. 2015
    ..hyperplasia (BAH) in humans and mice has been recently linked to phosphodiesterase (PDE) 8B (PDE8B) and 11 (PDE11A) defects...
  17. doi Genetics of primary bilateral macronodular adrenal hyperplasia: a model for early diagnosis of Cushing's syndrome?
    Ludivine Drougat
    Institut National de la Santé et de la Recherche Médicale INSERM U1016 Centre National de la Recherche Scientifique CNRS UMR 8104, Institut Cochin, Universite Paris Descartes, 75014 Paris, France Department of Endocrinology Referral Center for Rare Adrenal Diseases, Assistance Publique Hopitaux de Paris, Hopital Cochin, 27 rue du Faubourg St Jacques, 75014 Paris, France
    Eur J Endocrinol 173:M121-31. 2015
    ..Rare variants of the phosphodiesterases PDE11A have been associated with PBMAH...
  18. doi Rare inactivating PDE11A variants associated with testicular germ cell tumors
    Anand Pathak
    Clinical Genetics BranchDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USAProgram on Developmental Endocrinology and GeneticsEunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USACancer Genomics Research LaboratoryDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, Maryland, USAPerelman School of MedicineAbramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USAGenetic Epidemiology BranchHormonal and Reproductive Epidemiology BranchDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Room 6E422, Rockville, Maryland 20850, USA
    Endocr Relat Cancer 22:909-17. 2015
    Germline inactivating mutations of isoform 4 of phosphodiesterase (PDE) 11A (coded by the PDE11A gene) have been associated with familial adrenocortical tumors and familial testicular cancer...
  19. doi Active 3'-5' cyclic nucleotide phosphodiesterases are present in detergent-resistant membranes of mural granulosa cells
    Annick Bergeron
    Reprod Fertil Dev . 2016
    ..PDE6C, PDE8A and PDE11A were detected by dot blot in the DRMs and the Triton-soluble fraction of the mural granulosa cells membrane and ..
  20. doi A stop-codon of the phosphodiesterase 11A gene is associated with elevated blood pressure and measures of obesity
    Therese Ohlsson
    aDepartment of Clinical Sciences, Skane University Hospital, Lund University, MalmöbDepartment of Clinical Sciences Lund, Neurology, Lund UniversitycDepartment of Neurology and Rehabilitation Medicine, Neurology, Skane University Hospital, LunddDepartment of Medical and Clinical Genetics, Institute of Biomedicine, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    J Hypertens 34:445-51; discussion 451. 2016
    ..To identify stop-codon variants associated with blood pressure (BP)...
  21. pmc Phosphodiesterase 11A (PDE11A), Enriched in Ventral Hippocampus Neurons, is Required for Consolidation of Social but not Nonsocial Memories in Mice
    Shweta Hegde
    University of South Carolina School of Medicine, Columbia, SC, USA
    Neuropsychopharmacology 41:2920-2931. 2016
    ..Previously, we showed that PDE11A, which degrades cAMP and cGMP, is preferentially expressed in CA1 and subiculum of the VHIPP...
  22. pmc PDE11A regulates social behaviors and is a key mechanism by which social experience sculpts the brain
    Shweta Hegde
    Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, Columbia, SC 29209, United States
    Neuroscience 335:151-69. 2016
    ..Here, we determine if Phosphodiesterase 11A (PDE11A), an enzyme that is enriched in the ventral hippocampal formation (VHIPP) and that breaks down cAMP and cGMP, ..
  23. pmc Recurrent targeted genes of hepatitis B virus in the liver cancer genomes identified by a next-generation sequencing-based approach
    Dong Ding
    Hangzhou Proprium Biotech, Hangzhou, China
    PLoS Genet 8:e1003065. 2012
    ..LRP1B, ADAM21, NRXN1, FN1) containing IPR013032 (EGF-like region, conserved site), and three genes (PDE7A, PDE4B, PDE11A) containing IPR002073 (3', 5'-cyclic-nucleotide phosphodiesterase)...
  24. pmc Phosphodiesterase 11A (PDE11A) gene defects in patients with acth-independent macronodular adrenal hyperplasia (AIMAH): functional variants may contribute to genetic susceptibility of bilateral adrenal tumors
    Delphine Vezzosi
    Service d endocrinologie, Hopital Cochin 27, rue du Faubourg Saint Jacques, 75014 Paris, France
    J Clin Endocrinol Metab 97:E2063-9. 2012
    Phosphodiesterases (PDEs) are key regulatory enzymes of intracellular cAMP levels. PDE11A function has been linked to predisposition to adrenocortical tumors.
  25. pmc Promoter methylation of candidate genes associated with familial testicular cancer
    Lisa Mirabello
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services Bethesda, Maryland, USA
    Int J Mol Epidemiol Genet 3:213-27. 2012
    ..We also quantified gene product expression of these genes, using quantitative PCR. We observed increased PDE11A, SPRY4 and BAK1 promoter methylation, and decreased KITLG promoter methylation, in familial TGCT cases versus ..
  26. pmc Exploring the PDE5 H-pocket by ensemble docking and structure-based design and synthesis of novel β-carboline derivatives
    Nermin S Ahmed
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Main Entrance, Al Tagmoaa Al Khames, Cairo 11835, Egypt
    Eur J Med Chem 57:329-43. 2012
    ..compounds were as active as tadalafil in inhibiting PDE5 and of better selectivity profile particularly versus PDE11A, the nature of the terminal ring and its nitrogen substituent are the main determinants of selectivity...
  27. ncbi 3',5'-Cyclic nucleotide phosphodiesterase 11A: localization in human tissues
    Allen D Seftel
    J Urol 174:1044. 2005
  28. pmc Novel Mutation in PRKAR1A in Carney Complex
    Ko Un Park
    Indiana University School of Medicine, Indianapolis, IN, USA
    Korean J Pathol 46:595-600. 2012
    ..in the protein kinase A type I-a regulatory subunit (PRKAR1A) gene, but not in the phosphodiesterase type 11A (PDE11A) gene...
  29. pmc Cyclic AMP and c-KIT signaling in familial testicular germ cell tumor predisposition
    Monalisa F Azevedo
    Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 98:E1393-400. 2013
    ..We reported inactivating germline mutations of the cAMP-binding phosphodiesterase 11A (PDE11A) as modifiers of FTGCT risk...
  30. pmc A yeast-based chemical screen identifies a PDE inhibitor that elevates steroidogenesis in mouse Leydig cells via PDE8 and PDE4 inhibition
    Didem Demirbas
    Biology Department, Boston College, Chestnut Hill, Massachusetts, United States of America
    PLoS ONE 8:e71279. 2013
    ..This compound also displays significant activity against PDE10A and PDE11A. BC8-15 elevates steroidogenesis in mouse Leydig cells as a single pharmacological agent...
  31. doi Select 3',5'-cyclic nucleotide phosphodiesterases exhibit altered expression in the aged rodent brain
    Michy P Kelly
    University of South Carolina School of Medicine, Department of Pharmacology, Physiology and Neuroscience, 6439 Garners Ferry Rd, Columbia, SC 29209, USA Electronic address
    Cell Signal 26:383-97. 2014
    ..PDE1B, PDE1C, PDE2A, PDE4A, PDE4D, PDE5A, PDE7A, PDE8A, PDE8B, PDE10A, and PDE11A showed an age-related increase or decrease in mRNA expression in at least 1 of the 4 brain regions examined (..
  32. pmc Genetic risk factors in two Utah pedigrees at high risk for suicide
    H Coon
    Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT, USA
    Transl Psychiatry 3:e325. 2013
    ..and/or previous associations with psychiatric conditions were also identified, including NFKB1, CASP9, PLXNB1 and PDE11A in pedigree 12, and THOC1, and AUTS2 in pedigree 5...
  33. doi Binding of cyclic nucleotides to phosphodiesterase 10A and 11A GAF domains does not stimulate catalytic activity
    Karina Matthiesen
    Department of Molecular Neurobiology, H Lundbeck A S, Ottiliavej 9, 2500 Copenhagen Valby, Denmark
    Biochem J 423:401-9. 2009
    ..PDE10A and PDE11A are the two most recently described PDEs and it has been suggested that their GAF domains bind to cAMP and cGMP ..
  34. pmc Phosphodiesterase function and endocrine cells: links to human disease and roles in tumor development and treatment
    Isaac Levy
    Section of Endocrinology and Genetics, Program on Developmental Endocrinology Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Curr Opin Pharmacol 11:689-97. 2011
    ..Several associations between PDE genes and genetic diseases have been described, and more recently PDE11A and PDE8B have been implicated in predisposition to tumor formation...
  35. doi Expression and distribution of key enzymes of the cyclic GMP signaling in the human clitoris: relation to phosphodiesterase type 5 (PDE5)
    S Uckert
    Division of Surgery, Department of Urology and Urological Oncology, Hannover Medical School, Hannover, Germany
    Int J Impot Res 23:206-12. 2011
    ..Staining for PDE11A was observed in single nerve trunks located in the clitoral stroma...
  36. pmc Design, synthesis and structure-activity relationship of functionalized tetrahydro-β-carboline derivatives as novel PDE5 inhibitors
    Nermin S Ahmed
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt
    Arch Pharm (Weinheim) 344:149-57. 2011
    ..Compound XXI was also highly selective for PDE5 versus PDE3B, PDE4B, and PDE11A, with a selectivity index of 52 and 235 towards PDE5 rather than PDE11 with both cAMP and cGMP as substrate, ..
  37. pmc Carney complex and other conditions associated with micronodular adrenal hyperplasias
    Madson Q Almeida
    Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development NICHD, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Best Pract Res Clin Endocrinol Metab 24:907-14. 2010
    ..Phosphodiesterase-11A (the PDE11A gene) and -8B (the PDE8B gene) mutations were found in patients with isolated adrenal hyperplasia and Cushing ..
  38. pmc How does cAMP/protein kinase A signaling lead to tumors in the adrenal cortex and other tissues?
    Madson Q Almeida
    Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, United States
    Mol Cell Endocrinol 336:162-8. 2011
    ..cortisol-producing adenomas are associated with phosphodiesterase 11A and 8B defects, coded, respectively, by the PDE11A and PDE8B genes...
  39. pmc Frequent phosphodiesterase 11A gene (PDE11A) defects in patients with Carney complex (CNC) caused by PRKAR1A mutations: PDE11A may contribute to adrenal and testicular tumors in CNC as a modifier of the phenotype
    Rossella Libe
    Institut National de la Santé et de la Recherche Médicale Unité 1016, Institut Cochin, Centre National de la Recherche Scientifique Unite Mixte de Recherche 8104, Paris, France
    J Clin Endocrinol Metab 96:E208-14. 2011
    ..Germline, protein-truncating mutations of phosphodiesterase type 11A (PDE11A) have been described to predispose to a variety of endocrine tumors, including adrenal and testicular tumors.
  40. pmc Phosphodiesterase 11A (PDE11A) genetic variants may increase susceptibility to prostatic cancer
    Fabio Rueda Faucz
    Section of Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 96:E135-40. 2011
    ..for prostatic cancer (PCa) is the 2q31-33 chromosomal region that harbors the gene encoding phosphodiesterase 11A (PDE11A)...
  41. pmc Familial testicular germ cell tumours
    Christian P Kratz
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852, USA
    Best Pract Res Clin Endocrinol Metab 24:503-13. 2010
    ..recent candidate gene-association analyses have identified the chromosome Y gr/gr deletion and mutations in the PDE11A gene as genetic modifiers of FTGCT risk...
  42. doi Genetics of Cushing's syndrome
    Maria Yaneva
    Clinical Center of Endocrinology, Medical University, Sofia, Bulgaria
    Neuroendocrinology 92:6-10. 2010
    ..The cAMP signaling pathway is affected in this setting. In recent times the involvement of genes such as PDE11A, PDE8B and others have expanded the spectrum of the genetic pathophysiology of CS.
  43. pmc Phosphodiesterase 11A in brain is enriched in ventral hippocampus and deletion causes psychiatric disease-related phenotypes
    Michele P Kelly
    Pfizer Research, Princeton, NJ 08852, USA
    Proc Natl Acad Sci U S A 107:8457-62. 2010
    Phosphodiesterase 11A (PDE11A) is the most recently identified family of phosphodiesterases (PDEs), the only known enzymes to break down cyclic nucleotides...
  44. ncbi Phosphodiesterase 11 (PDE11): is it a player in human testicular function?
    S H Francis
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    Int J Impot Res 17:467-8. 2005
    ..In the light of tadalafil's commercial success, its inhibition of PDE11A has been the subject of heated debate...
  45. pmc Unraveling the molecular basis of micronodular adrenal hyperplasia
    Anelia Horvath
    Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1862, USA
    Curr Opin Endocrinol Diabetes Obes 15:227-33. 2008
    ..It focuses on the role of genetic defects in cyclic-AMP (cAMP) signaling-related molecules, namely PRKAR1A, GNAS, PDE11A, and PDE8B in the predisposition to tumor formation...
  46. pmc A cAMP-specific phosphodiesterase (PDE8B) that is mutated in adrenal hyperplasia is expressed widely in human and mouse tissues: a novel PDE8B isoform in human adrenal cortex
    Anelia Horvath
    Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
    Eur J Hum Genet 16:1245-53. 2008
    ..A genome-wide association study identified inactivating phosphodiesterase (PDE) 11A (PDE11A)-sequencing defects as low-penetrance predisposing factors for iMAD and related abnormalities; we also described a ..
  47. pmc Detection of somatic beta-catenin mutations in primary pigmented nodular adrenocortical disease (PPNAD)
    Mimi Tadjine
    Division of Endocrinology, Department of Medicine, Centre hospitalier de l Université de Montréal CHUM Hôtel Dieu, Montreal, QC, Canada
    Clin Endocrinol (Oxf) 69:367-73. 2008
    ..of the type 1-alpha regulatory subunit of cAMP-dependent protein kinase A (PRKAR1A) and phosphodiesterase 11A4 (PDE11A) genes have been found in PPNAD...
  48. doi The properties of phosphodiesterase 11A4 GAF domains are regulated by modifications in its N-terminal domain
    Marco Gross-Langenhoff
    Pharmazeutisches Institut, Universitat Tubingen, Morgenstelle 8, Tubingen, Germany
    FEBS J 275:1643-50. 2008
    ..The decrease in EC(50) values was accompanied by a sixfold increase in basal activity; the extent of cGMP stimulation remained unaffected, however. We conclude that N-terminal modifications strongly affect cGMP regulation of hPDE11A4...
  49. ncbi N-Terminal domain of phosphodiesterase-11A4 (PDE11A4) decreases affinity of the catalytic site for substrates and tadalafil, and is involved in oligomerization
    James L Weeks
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 702 Light Hall, Nashville, Tennessee 37232 0615, USA
    Biochemistry 46:10353-64. 2007
    ..the N-terminal region of PDE11A4 on the affinity of the catalytic domain for both substrates and inhibitors and the first to define the quaternary structure and the regions that contribute to this structure within the human PDE11A family.
  50. ncbi Adrenocortical tumors, primary pigmented adrenocortical disease (PPNAD)/Carney complex, and other bilateral hyperplasias: the NIH studies
    C A Stratakis
    Pediatric Endocrinology, National Institute of Child Health and Human Development, Bethesda, Maryland 20892 1862, USA
    Horm Metab Res 39:467-73. 2007
    ..This recently led to the identification of phosphodiesterase 11A ( PDE11A) mutations as a low-penetrance predisposing factor to adrenocortical hyperplasias of both the pigmented and non-..
  51. ncbi PRKAR1A mutations in primary pigmented nodular adrenocortical disease
    Laure Cazabat
    INSERM U567, Paris, France
    Pituitary 9:211-9. 2006
    ..Interestingly, both PRKAR1A and PDE11A gene products control the cAMP signaling pathway, which can be altered at various levels in endocrine tumors.
  52. ncbi cAMP is a ligand for the tandem GAF domain of human phosphodiesterase 10 and cGMP for the tandem GAF domain of phosphodiesterase 11
    Marco Gross-Langenhoff
    Abteilung Pharmazeutische Biochemie, Fakultät für Chemie und Pharmazie, Universitat Tubingen, Morgenstelle 8, 72076 Tubingen, Germany
    J Biol Chem 281:2841-6. 2006
    ..The data appeared to define those GAF domains as a distinct subclass within the >3100 annotated GAF domains for which we propose a tentative classification scheme...
  53. pmc Phosphodiesterase 11A expression in the adrenal cortex, primary pigmented nodular adrenocortical disease, and other corticotropin-independent lesions
    S A Boikos
    Section on Endocrinology and Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
    Horm Metab Res 40:347-53. 2008
    ..disease" (iMAD) in whom CS was associated with inactivating mutations in phosphodiesterase (PDE) 11A ( PDE11A)...
  54. ncbi Expression of PDE11A in normal and malignant human tissues
    Michael R D'Andrea
    Drug Discovery, Johnson and Johnson Pharmaceutical Research and Development, LLC, 1000 Route 202, Raritan, NJ 08869, USA
    J Histochem Cytochem 53:895-903. 2005
    Cyclic nucleotide phosphodiesterase 11A (PDE11A) is the newest member in the PDE family. Although the tissue distribution of PDE11A mRNA has been shown, its protein expression pattern has not been well studied...
  55. ncbi 3',5'-cyclic nucleotide phosphodiesterase 11A: localization in human tissues
    K Loughney
    ICOS Corporation, Bothell, WA, USA
    Int J Impot Res 17:320-5. 2005
    ..This family contains one gene, PDE11A, with four splice variants (PDE11A1-PDE11A4). The physiological role of PDE11A has not been determined...
  56. ncbi Dexamethasone down-regulates cAMP-phosphodiesterase in human osteosarcoma cells
    Mikael Ahlstrom
    Department of Applied Chemistry and Microbiology, University of Helsinki, P O Box 66, Helsinki 00014, Finland
    Biochem Pharmacol 69:267-75. 2005
    ..PCR (RT-PCR): PDE1A, PDE1C, PDE2A, PDE3A, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE10A and PDE11A. Using semi-quantitative RT-PCR, we detected a 50-70% decrease in the mRNA of PDE4A and PDE4B subtypes following ..
  57. ncbi High biochemical selectivity of tadalafil, sildenafil and vardenafil for human phosphodiesterase 5A1 (PDE5) over PDE11A4 suggests the absence of PDE11A4 cross-reaction in patients
    J L Weeks
    Department of Molecular Physiology and Biophysics, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232 0615, USA
    Int J Impot Res 17:5-9. 2005
    ..PDE5A1/PDE11A4 selectivities are 40-, 9300-, and 1000-fold for tadalafil, vardenafil, and sildenafil, respectively. This suggests that none of these three compounds is likely to crossreact with PDE11A4 in patients...
  58. ncbi Identification of rat cyclic nucleotide phosphodiesterase 11A (PDE11A): comparison of rat and human PDE11A splicing variants
    K Yuasa
    Discovery Research Laboratory, Tanabe Seiyaku Co Ltd, Saitama, Japan
    Eur J Biochem 268:4440-8. 2001
    ..The deduced amino-acid sequence of the longest form of rat PDE11A splice variant, RNPDE11A4, was 94% identical with that of the human variant (HSPDE11A4)...
  59. ncbi Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases
    K Loughney
    ICOS Corporation, Bothell, Washington 98021, USA
    J Biol Chem 271:796-806. 1996
    ..Both PDE1C enzymes were inhibited by isobutylmethylxanthine, 8-methoxymethyl isobutylmethylxanthine, zaprinast, and vinpocetine...
  60. pmc Multiple endocrine neoplasias: advances and challenges for the future
    M Alevizaki
    Endocrine Unit, Evgenideion Hospital and Department Medical Therapeutics, Alexandra Hospital, Athens University School of Medicine, 80, Vassilissis Sofias Ave, Athens 11528, Greece
    J Intern Med 266:1-4. 2009
    ..This editorial summarizes some of these advances: the identification of the AIP, and the PDE11A and PDE8B genes by genome-wide association (GWA) studies as predisposing genes for pituitary and adrenal tumours, ..
  61. pmc Familial testicular germ cell tumors in adults: 2010 summary of genetic risk factors and clinical phenotype
    Mark H Greene
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20852, USA
    Endocr Relat Cancer 17:R109-21. 2010
    ..Candidate gene-association studies have implicated the Y chromosome gr/gr deletion and PDE11A gene mutations as genetic modifiers of FTGCT risk...
  62. doi Failure to replicate genetic associations with antidepressant treatment response in duloxetine-treated patients
    Roy H Perlis
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Biol Psychiatry 67:1110-3. 2010
    ..We sought to replicate these associations in a study of a serotonin-norepinephrine reuptake inhibitor...
  63. pmc ACTH-independent Cushing's syndrome with bilateral micronodular adrenal hyperplasia and ectopic adrenocortical adenoma
    Estelle Louiset
    Institut National de la Sante et de la Recherche Medicale, Unité 982 Equipe Associée 4310, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institut Fédératif de Recherches Multidisciplinaires sur les Peptides 23, University of Rouen, 76821 Mont Saint Aignan, France
    J Clin Endocrinol Metab 95:18-24. 2010
    ..Bilateral micronodular adrenal hyperplasia and ectopic adrenocortical adenoma are two rare causes of ACTH-independent Cushing's syndrome...
  64. pmc Pharmacogenetics studies in STAR*D: strengths, limitations, and results
    Gonzalo Laje
    Genetic Basis of Mood and Anxiety Disorders Unit, National Institute of Mental Health, Bethesda, MD 20892, USA
    Psychiatr Serv 60:1446-57. 2009
    ..Replication was achieved in markers in the FKBP5 gene. Other findings in PDE11A and BDNF were not successfully replicated, and reports of potential confounders in previous associations with ..
  65. ncbi Multiple cyclic nucleotide phosphodiesterases
    J A Beavo
    Department of Pharmacology, University of Washington, Seattle 98195
    Mol Pharmacol 46:399-405. 1994
  66. doi Analysis of genetic variants of phosphodiesterase 11A in acromegalic patients
    E Peverelli
    Endocrinology and Diabetology Unit, Department of Medical Sciences, University of Milan, Padiglione Granelli, Fondazione Ospedale Maggiore IRCCS, Via F Sforza, 35, 20122 Milan, Italy
    Eur J Endocrinol 161:687-94. 2009
    ..The aim of the study was to screen acromegalic patients for the presence of variants of phosphodiesterase type 11A (PDE11A) gene, which have been recently identified in adrenocortical and testicular tumors.
  67. pmc Association of PDE11A global haplotype with major depression and antidepressant drug response
    Huai Rong Luo
    Center on Pharmacogenomics, Department of Psychiatry and Behavioral Science, University of Miami Miller School of Medicine, Miami, FL, USA
    Neuropsychiatr Dis Treat 5:163-70. 2009
    ..We have previously shown that the individual haplotype GAACC in the PDE11A gene was associated with major depressive disorder (MDD) based on block-by-block analysis...
  68. pmc Functional phosphodiesterase 11A mutations may modify the risk of familial and bilateral testicular germ cell tumors
    Anelia Horvath
    Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, 10 Center Drive, CRC, Room 1 3330, Bethesda, MD 20892, USA
    Cancer Res 69:5301-6. 2009
    Inactivating germline mutations in phosphodiesterase 11A (PDE11A) have been implicated in adrenal tumor susceptibility...
  69. pmc Familial micronodular adrenocortical disease, Cushing syndrome, and mutations of the gene encoding phosphodiesterase 11A4 (PDE11A)
    J Aidan Carney
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Surg Pathol 34:547-55. 2010
    ..In the remaining patient, the glands were slightly enlarged primarily owing to a diffuse hyperplasia of the superficial cortex that extended into the epi-adrenal fat...
  70. pmc Clinical and genetic heterogeneity, overlap with other tumor syndromes, and atypical glucocorticoid hormone secretion in adrenocorticotropin-independent macronodular adrenal hyperplasia compared with other adrenocortical tumors
    Hui Pin Hsiao
    Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, National Institute of Child Health and Human Development, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    J Clin Endocrinol Metab 94:2930-7. 2009
    ..We characterized a large series of patients of AIMAH and compared them with patients with other adrenocortical tumors...
  71. doi PDE9A, PDE10A, and PDE11A expression in rat trigeminovascular pain signalling system
    Lars S Kruse
    Danish Headache Center, Department of Neurology, Glostrup Hospital, Nordre Ringvej 57, Glostrup, Denmark
    Brain Res 1281:25-34. 2009
    ..Real-time PCR and Western blotting showed that PDE9A, PDE10A and PDE11A are expressed in components of the rat trigeminovascular pain signalling system including middle cerebral artery, ..
  72. pmc Abnormalities of cAMP signaling are present in adrenocortical lesions associated with ACTH-independent Cushing syndrome despite the absence of mutations in known genes
    Eirini I Bimpaki
    Eunice Kennedy Shriver National Institute of Child Health and Human Development NICHD, NIH, Building 10, CRC East Laboratories, Room 1 3330, 10 Center Drive, MSC1103, Bethesda, Maryland 20892, USA
    Eur J Endocrinol 161:153-61. 2009
    ..Little is known about cAMP signaling in adrenal lesions associated with ACTH-independent Cushing syndrome (AICS) that do not harbor mutations in known genes...
  73. pmc Association study of phosphodiesterase genes in the Sequenced Treatment Alternatives to Relieve Depression sample
    Michael Cabanero
    Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 3719, USA
    Pharmacogenet Genomics 19:235-8. 2009
    ..We genotyped three single nucleotide polymorphisms (SNPs) in PDE11A (rs1880916), PDE1A (rs1549870), and PDE9A (rs729861) for replication and we also report three additional SNPs in ..
  74. pmc New genes and/or molecular pathways associated with adrenal hyperplasias and related adrenocortical tumors
    Constantine A Stratakis
    Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics PDEGEN, Eunice Kennedy Shriver National Institute of Child Health and Human Development NICHD, Bethesda, MD 20892, USA
    Mol Cell Endocrinol 300:152-7. 2009
    ..Phosphodiesterase-11A (the PDE11A gene) and -8B (the PDE8B gene) mutations were found in patients with isolated adrenal hyperplasia and Cushing ..
  75. doi Phosphodiesterase 3 and 4 comprise the major cAMP metabolizing enzymes responsible for insulin secretion in INS-1 (832/13) cells and rat islets
    Deena Waddleton
    Department of Biochemistry and Molecular Biology, Merck Frosst Center for Therapeutic Research, Kirkland, Quebec, Canada
    Biochem Pharmacol 76:884-93. 2008
    ..PDE1C, PDE3B, PDE4C, PDE8B, PDE10A, and PDE11A were significantly expressed in rat islets and INS-1 (832/13) cells at the mRNA level...
  76. pmc Phosphodiesterase 11A (PDE11A) and genetic predisposition to adrenocortical tumors
    Rossella Libe
    INSERM U567
    Clin Cancer Res 14:4016-24. 2008
    We have reported previously nonsense inactivating mutations of the phosphodiesterase 11A (PDE11A) gene in patients with micronodular adrenocortical hyperplasia and Cushing syndrome...

Research Grants5

  1. John R Kelsoe; Fiscal Year: 2015
    ..Conversely, the gene for the phosphodiesterase PDE11A was associated with response for all forms of mania...
  2. John R Kelsoe; Fiscal Year: 2014
    ..Studies to date by our group have implicated two genes, NTRK2 and PDE11A as predicting response to lithium...
  3. CNS transcription modulation in peripheral inflammation
    Ma Li Wong; Fiscal Year: 2002
    ..The proposed studies will result in new data that will be needed for us to generate novel testable hypotheses, which will provide the framework for future R0l applications. ..
  4. Depression/Metabolic Syndrome in Mexican-American Women.
    Ma Li Wong; Fiscal Year: 2006
    ..This work will address this important area by the study of an population group who is markedly under represented in patient-oriented investigation. [unreadable] [unreadable]..
  5. Pharmacogenetics of Antidepressant Drugs
    Ma Li Wong; Fiscal Year: 2007
    ..This K-24 award will make possible for the P.I. to significantly increase her time allocation for patient-oriented research and for mentoring of junior trainees and fellows in clinical research. [unreadable] [unreadable]..