PDCD4

Summary

Gene Symbol: PDCD4
Description: programmed cell death 4
Alias: H731, programmed cell death protein 4, neoplastic transformation inhibitor protein, nuclear antigen H731, programmed cell death 4 (neoplastic transformation inhibitor), protein 197/15a
Species: human

Top Publications

  1. ncbi Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells
    Lisa B Frankel
    Biotech Research and Innovation Centre, Bioinformatics Centre, University of Copenhagen, DK 2200 N Copenhagen, Denmark
    J Biol Chem 283:1026-33. 2008
  2. doi MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene
    Z Lu
    Department of Biochemistry and Molecular Biology, University of Louisville, Louisville, KY 40202, USA
    Oncogene 27:4373-9. 2008
  3. ncbi Clinicopathological and prognostic significance of PDCD4 and microRNA-21 in human gastric cancer
    Kazuo Motoyama
    Department of Molecular and Surgical Oncology, Medical Institute of Bioregulation, Kyushu University, Beppu 874 0838, Japan
    Int J Oncol 36:1089-95. 2010
  4. doi Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21
    Frederick J Sheedy
    School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
    Nat Immunol 11:141-7. 2010
  5. doi MicroRNA-21 promotes cell proliferation and down-regulates the expression of programmed cell death 4 (PDCD4) in HeLa cervical carcinoma cells
    Qing Yao
    Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory for Biocontrol, Sun Yat Sen University, Guangzhou 510275, PR China
    Biochem Biophys Res Commun 388:539-42. 2009
  6. doi Ursolic acid inhibits proliferation and induces apoptosis in human glioblastoma cell lines U251 by suppressing TGF-β1/miR-21/PDCD4 pathway
    Jian Wang
    Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, China
    Basic Clin Pharmacol Toxicol 111:106-12. 2012
  7. doi Down-regulation of PDCD4 expression is an independent predictor of poor prognosis in human renal cell carcinoma patients
    Xiancheng Li
    Department of Urology, First Affiliated Hospital of Dalian Medical University, 116011 Dalian, China
    J Cancer Res Clin Oncol 138:529-35. 2012
  8. pmc miR-21 promotes fibrogenic epithelial-to-mesenchymal transition of epicardial mesothelial cells involving Programmed Cell Death 4 and Sprouty-1
    Hasse Brønnum
    Laboratory for Molecular and Cellular Cardiology, Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark
    PLoS ONE 8:e56280. 2013
  9. pmc The autoregulatory feedback loop of microRNA-21/programmed cell death protein 4/activation protein-1 (MiR-21/PDCD4/AP-1) as a driving force for hepatic fibrosis development
    Zhengping Zhang
    From the State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China and
    J Biol Chem 288:37082-93. 2013
  10. pmc Programmed cell death 4 (PDCD4) expression during multistep Barrett's carcinogenesis
    Matteo Fassan
    Department of Medical Diagnostic Sciences, University of Padova, Padova, Italy
    J Clin Pathol 63:692-6. 2010

Research Grants

  1. Role of miRNAs in Vascular Physiology
    Akiko Hata; Fiscal Year: 2012
  2. Gang Liu; Fiscal Year: 2015
  3. Asim B Abdel-Mageed; Fiscal Year: 2015
  4. Michele Pagano; Fiscal Year: 2016
  5. The Effect of Diet and Nutrients on the Progression and Treatment of Prostate Can
    George Thomas; Fiscal Year: 2013
  6. TGF-Beta signaling and microRNA processing: Implications for invasion and metasta
    ANA CLARA PEREIRA AZEVEDO-POULY; Fiscal Year: 2012
  7. The role of Pdcd4 in colorectal tumor progression
    Hsin Sheng Yang; Fiscal Year: 2013
  8. Leonidas C Platanias; Fiscal Year: 2016
  9. Leonard S Jefferson; Fiscal Year: 2015
  10. Katharine S Ullman; Fiscal Year: 2014

Detail Information

Publications156 found, 100 shown here

  1. ncbi Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells
    Lisa B Frankel
    Biotech Research and Innovation Centre, Bioinformatics Centre, University of Copenhagen, DK 2200 N Copenhagen, Denmark
    J Biol Chem 283:1026-33. 2008
    ..We furthermore found that the tumor suppressor protein Programmed Cell Death 4 (PDCD4) is regulated by miR-21 and demonstrated that PDCD4 is a functionally important target for miR-21 in breast cancer ..
  2. doi MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene
    Z Lu
    Department of Biochemistry and Molecular Biology, University of Louisville, Louisville, KY 40202, USA
    Oncogene 27:4373-9. 2008
    ..using a reporter assay and identified a potential miR-21 target in the 3'-UTR of the programmed cell death 4 (PDCD4) gene...
  3. ncbi Clinicopathological and prognostic significance of PDCD4 and microRNA-21 in human gastric cancer
    Kazuo Motoyama
    Department of Molecular and Surgical Oncology, Medical Institute of Bioregulation, Kyushu University, Beppu 874 0838, Japan
    Int J Oncol 36:1089-95. 2010
    Recent studies have demonstrated that the novel tumor suppressor protein programmed cell death 4 (PDCD4) is downregulated in several human solid cancer types and is suppressed by microRNA-21 (miR-21)...
  4. doi Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21
    Frederick J Sheedy
    School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
    Nat Immunol 11:141-7. 2010
    The tumor suppressor PDCD4 is a proinflammatory protein that promotes activation of the transcription factor NF-kappaB and suppresses interleukin 10 (IL-10)...
  5. doi MicroRNA-21 promotes cell proliferation and down-regulates the expression of programmed cell death 4 (PDCD4) in HeLa cervical carcinoma cells
    Qing Yao
    Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory for Biocontrol, Sun Yat Sen University, Guangzhou 510275, PR China
    Biochem Biophys Res Commun 388:539-42. 2009
    ..caused profound suppression of cell proliferation, and up-regulated the expression of the tumor suppressor gene PDCD4. We also provide direct evidence that PDCD4-3'UTR is a functional target of miR-21 and that the 18bp putative ..
  6. doi Ursolic acid inhibits proliferation and induces apoptosis in human glioblastoma cell lines U251 by suppressing TGF-β1/miR-21/PDCD4 pathway
    Jian Wang
    Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, China
    Basic Clin Pharmacol Toxicol 111:106-12. 2012
    ..The expression of programmed cell death 4 (PDCD4), which is a miR-21 targeting apoptotic gene, has also been enhanced by UA...
  7. doi Down-regulation of PDCD4 expression is an independent predictor of poor prognosis in human renal cell carcinoma patients
    Xiancheng Li
    Department of Urology, First Affiliated Hospital of Dalian Medical University, 116011 Dalian, China
    J Cancer Res Clin Oncol 138:529-35. 2012
    The tumor suppressor gene entitled programmed cell death 4 (PDCD4) encodes a protein that inhibits neoplastic transformation and invasion...
  8. pmc miR-21 promotes fibrogenic epithelial-to-mesenchymal transition of epicardial mesothelial cells involving Programmed Cell Death 4 and Sprouty-1
    Hasse Brønnum
    Laboratory for Molecular and Cellular Cardiology, Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark
    PLoS ONE 8:e56280. 2013
    ..differentially regulated during fibrogenic EMT of EMCs and miR-21-dependent targeting of Programmed Cell Death 4 (PDCD4) and Sprouty Homolog 1 (SPRY1) significantly contributed to the development of a fibroblastoid phenotype...
  9. pmc The autoregulatory feedback loop of microRNA-21/programmed cell death protein 4/activation protein-1 (MiR-21/PDCD4/AP-1) as a driving force for hepatic fibrosis development
    Zhengping Zhang
    From the State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China and
    J Biol Chem 288:37082-93. 2013
    ..We further found that miR-21 maintained itself at constant high levels by using a microRNA-21/programmed cell death protein 4/activation protein-1 (miR-21/PDCD4/AP-1) feedback loop...
  10. pmc Programmed cell death 4 (PDCD4) expression during multistep Barrett's carcinogenesis
    Matteo Fassan
    Department of Medical Diagnostic Sciences, University of Padova, Padova, Italy
    J Clin Pathol 63:692-6. 2010
    To test the contribution of programmed cell death 4 (PDCD4) tumour suppressor gene in Barrett's carcinogenesis.
  11. ncbi Akt phosphorylates and regulates Pdcd4 tumor suppressor protein
    Alexey Palamarchuk
    Comprehensive Cancer Center, Human Cancer Genetics Program, and Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University School of Medicine, Columbus, 43210, USA
    Cancer Res 65:11282-6. 2005
    Programmed cell death 4 (Pdcd4) is a tumor suppressor protein that interacts with eukaryotic initiation factor 4A and inhibits protein synthesis...
  12. pmc Downregulation of E-cadherin is an essential event in activating beta-catenin/Tcf-dependent transcription and expression of its target genes in Pdcd4 knockdown cells
    Q Wang
    Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, KY 40536, USA
    Oncogene 29:128-38. 2010
    We reported earlier that knockdown of tumor suppressor Pdcd4 (programed cell death 4) downregulates E-cadherin expression and activates beta-catenin/Tcf (T-cell factor)-dependent transcription in colon tumor cells...
  13. ncbi Programmed cell death 4 protein in esophageal cancer
    Matteo Fassan
    Department of Medical Diagnostic Sciences and Special Therapies, University of Padova, Padova PD, I 35100, Italy
    Oncol Rep 24:135-9. 2010
    Screening for genes down-regulated in esophageal cancers (Oncomine database) pinpointed programmed cell death 4 (PDCD4) as one of the most consistently involved...
  14. ncbi Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death
    K Shibahara
    Department of Medical Chemistry, Kyoto University Faculty of Medicine, Japan
    Gene 166:297-301. 1995
    ..The MA-3 gene was highly conserved during evolution and cross-hybridization bands were found not only in vertebrates but also in Drosophila melanogaster...
  15. ncbi Differential transcriptional regulation of CD161 and a novel gene, 197/15a, by IL-2, IL-15, and IL-12 in NK and T cells
    L Azzoni
    Department of Microbiology and Immunology, Kimmel Cancer Center, Jefferson Medical College, Philadelphia, PA 19107, USA
    J Immunol 161:3493-500. 1998
    ....
  16. ncbi Novel human PDCD4 (H731) gene expressed in proliferative cells is expressed in the small duct epithelial cells of the breast as revealed by an anti-H731 antibody
    H Yoshinaga
    Department of Biochemistry, Saga Medical School, Nabeshima, Japan
    Pathol Int 49:1067-77. 1999
    The novel gene H731 (approved name: PDCD4 (programmed cell death 4)) has been isolated as an antigen gene of the monoclonal antibody Pr-28 which recognized a nuclear antigen in proliferating cells...
  17. ncbi Loss of PDCD4 expression in human lung cancer correlates with tumour progression and prognosis
    Yuan Chen
    Institute of Pathology, University Hospital Charite, Humboldt University, Schumannstrasse 20 21, D 10098 Berlin, Germany
    J Pathol 200:640-6. 2003
    The programmed cell death 4 gene (PDCD4), a newly identified transformation suppressor, was analysed in lung tumour cell lines and primary lung carcinomas...
  18. pmc A novel function of the MA-3 domains in transformation and translation suppressor Pdcd4 is essential for its binding to eukaryotic translation initiation factor 4A
    Hsin Sheng Yang
    Gene Regulation Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, USA
    Mol Cell Biol 24:3894-906. 2004
    ..human eukaryotic translation initiation factor 4G (eIF4G) and DAP-5/NAT1/p97, as well as in the tumor suppressor Pdcd4. The function of the MA-3 domain is, however, unknown...
  19. ncbi Programmed cell death protein 4 suppresses CDK1/cdc2 via induction of p21(Waf1/Cip1)
    R Göke
    Clinical Research Unit, University Hospital of Marburg, Baldingerstrasse, D 35033 Marburg, Germany
    Am J Physiol Cell Physiol 287:C1541-6. 2004
    We show that the recently discovered tumor suppressor pdcd4 represses the transcription of the mitosis-promoting factor cyclin-dependent kinase (CDK)1/cdc2 via upregulation of p21(Waf1/Cip1). p21(Waf1/Cip1) inhibits CDK4/6 and CDK2...
  20. ncbi S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth
    N Valerio Dorrello
    Department of Pathology, NYU Cancer Institute, New York University School of Medicine, 550 First Avenue, MSB 599, New York, NY 10016, USA
    Science 314:467-71. 2006
    The tumor suppressor programmed cell death protein 4 (PDCD4) inhibits the translation initiation factor eIF4A, an RNA helicase that catalyzes the unwinding of secondary structure at the 5' untranslated region (5'UTR) of messenger RNAs (..
  21. ncbi Tumor suppressor Pdcd4 inhibits invasion/intravasation and regulates urokinase receptor (u-PAR) gene expression via Sp-transcription factors
    J H Leupold
    The Department of Experimental Surgery and Molecular Oncology of Solid Tumors, Medical Faculty Mannheim, University Heidelberg and DKFZ Heidelberg, Germany
    Oncogene 26:4550-62. 2007
    Tumor suppressor Pdcd4 has recently been shown to inhibit invasion by activating activator protein-1 (AP-1); however, little is known of the functionally significant Pdcd4-target genes...
  22. ncbi Downregulation of tumor suppressor Pdcd4 promotes invasion and activates both beta-catenin/Tcf and AP-1-dependent transcription in colon carcinoma cells
    Q Wang
    Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, KY, USA
    Oncogene 27:1527-35. 2008
    Programmed cell death 4 (Pdcd4) is a tumor suppressor that inhibits neoplastic transformation and tumor invasion...
  23. ncbi Loss of programmed cell death 4 expression marks adenoma-carcinoma transition, correlates inversely with phosphorylated protein kinase B, and is an independent prognostic factor in resected colorectal cancer
    Giridhar Mudduluru
    Department of Experimental Surgery Mannheim Molecular Oncology of Solid Tumors, Deutsches Krebsforschungszentrum and University Heidelberg, Mannheim, Germany
    Cancer 110:1697-707. 2007
    Programmed cell death 4 (Pdcd4) inhibits malignant transformation, and initial studies of Pdcd4 suggested the regulation of Pdcd4 localization by protein kinase B (Akt)...
  24. ncbi The action of Pdcd4 may be cell type specific: evidence that reduction of dUTPase levels might contribute to its tumor suppressor activity in Bon-1 cells
    Brigitte Lankat-Buttgereit
    Clinical Research Unit for Gastrointestinal Endocrinology, University Hospital of Giessen and Marburg, Baldingerstrasse, Marburg, Germany
    Apoptosis 13:157-64. 2008
    Pdcd4 (programmed cell death protein 4) was identified as a gene up-regulated during apoptosis and, additionally, seems to have a function as a tumor suppressor...
  25. pmc PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains
    Chikako Suzuki
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:3274-9. 2008
    Programmed Cell Death 4 (PDCD4) is a protein known to bind eukaryotic initiation factor 4A (eIF4A), inhibit translation initiation, and act as a tumor suppressor...
  26. doi siRNA-mediated knockdown of Pdcd4 expression causes upregulation of p21(Waf1/Cip1) expression
    N Bitomsky
    1Institut für Biochemie, Westfalische Wilhelms Universitat Munster, Munster, Germany
    Oncogene 27:4820-9. 2008
    The transformation suppressor gene, programmed cell death gene 4 (Pdcd4), inhibits tumor-promoter-mediated transformation of mouse keratinocytes and has been implicated as a tumor suppressor gene in the development of human cancer...
  27. pmc SMAD proteins control DROSHA-mediated microRNA maturation
    Brandi N Davis
    Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Nature 454:56-61. 2008
    ..miR-21 downregulates PDCD4 (programmed cell death 4), which in turn acts as a negative regulator of smooth muscle contractile genes...
  28. doi MicroRNA-21 down-regulates the expression of tumor suppressor PDCD4 in human glioblastoma cell T98G
    Yang Chen
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, No 5 Dong Dan San Tiao, Beijing 100005, PR China
    Cancer Lett 272:197-205. 2008
    ..Luciferase activity assay showed that a number of genes involved in apoptosis, PDCD4, MTAP, and SOX5, carry putative miR-21 binding sites...
  29. ncbi Expression and prognostic significance of PDCD4 in human epithelial ovarian carcinoma
    Xiaoyan Wang
    Institute of Immunology, School of Medicine, Shandong University, Jinan 250012, Shandong, P R China
    Anticancer Res 28:2991-6. 2008
    Programmed cell death 4 (PDCD4) is a newly discovered tumor suppressor. The aim of this study was to investigate the expression and prognostic significance of PDCD4 in epithelial ovarian cancer.
  30. pmc Structural basis for translational inhibition by the tumour suppressor Pdcd4
    Portia G Loh
    Institute of Molecular and Cell Biology, Proteos, Singapore
    EMBO J 28:274-85. 2009
    b>Pdcd4 is a tumour suppressor protein. It inhibits translation through interaction with translation initiator eIF4A, resulting in the suppression of neoplastic transformation and tumour invasion...
  31. pmc Crystal structure of the eIF4A-PDCD4 complex
    Jeong Ho Chang
    National Creative Initiatives for Structural Biology and Department of Life Science, Pohang University of Science and Technology, Hyo ja dong, San31, Pohang, KyungBook, South Korea
    Proc Natl Acad Sci U S A 106:3148-53. 2009
    Tumor suppressor programmed cell death protein 4 (PDCD4) inhibits the translation initiation factor eIF4A, an RNA helicase that catalyzes the unwinding of secondary structure at the 5'-untranslated region of mRNAs and controls the ..
  32. pmc Loss of Programmed cell death 4 (Pdcd4) associates with the progression of ovarian cancer
    N A Wei
    Department of Obstetrics and Gynaecology, Queen Mary Hospital, University of Hong Kong, Hong Kong, PR China
    Mol Cancer 8:70. 2009
    Programmed cell death 4 (Pdcd4) is a novel tumour suppressor and originally identified as a neoplastic transformation inhibitor...
  33. doi Pdcd4, a colon cancer prognostic that is regulated by a microRNA
    Heike Allgayer
    Dept Experimental Surgery Molecular Oncology of Solid Tumors Collaboration Unit German Cancer Research Center DKFZ Heidelberg, Medical Faculty Mannheim, Ruprecht Karls University Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Crit Rev Oncol Hematol 73:185-91. 2010
    The novel tumor suppressor Pdcd4 inhibits neoplastic transformation, tumor progression and translation...
  34. doi Interaction of Pdcd4 with eIF4E inhibits the metastatic potential of hepatocellular carcinoma
    Ying Jiang
    Department of Gastroenterology, Provincial Hospital, Shandong University, 324, Jingwu Road, Jinan Shandong, 250021, PR China
    Biomed Pharmacother 64:424-9. 2010
    ..We also found that PDCD4 inhibits JNK activity resulting in inhibition of the phosphorylation of c-Jun, one isoform of AP-1...
  35. pmc Pdcd4 repression of lysyl oxidase inhibits hypoxia-induced breast cancer cell invasion
    A N Santhanam
    Gene Regulation Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
    Oncogene 29:3921-32. 2010
    ..Our studies have revealed that the novel tumor suppressor Pdcd4 inhibits breast cancer cell migration and invasion in vitro...
  36. doi Programmed cell death 4 (PDCD4) mediates the sensitivity of gastric cancer cells to TRAIL-induced apoptosis by down-regulation of FLIP expression
    Weiqiang Wang
    Department of Gastroenterology, Southwest Hospital, The Third Military Medical University, Chongqing 400038, China
    Exp Cell Res 316:2456-64. 2010
    ..We first detected expression of programmed cell death 4 (PDCD4) in three gastric cancer cell lines and identified its association with the sensitivity of gastric cancer cells to ..
  37. doi Pdcd4 expression in intraductal papillary mucinous neoplasm of the pancreas: its association with tumor progression and proliferation
    Akifumi Hayashi
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University 3 1 1 Maidashi, Fukuoka, 812 8582, Japan
    Hum Pathol 41:1507-15. 2010
    ..Therefore, programmed cell death 4 can be an important biomarker for intraductal papillary mucinous neoplasm...
  38. doi Programmed cell death 4 enhances chemosensitivity of ovarian cancer cells by activating death receptor pathway in vitro and in vivo
    Xia Zhang
    Department of Immunology, Shandong University School of Medicine, Jinan, China
    Cancer Sci 101:2163-70. 2010
    ..We previously reported that programmed cell death 4 (PDCD4), a tumor suppressor, significantly suppresses the malignant phenotype of ovarian cancer cells and its lost or low ..
  39. pmc Programmed cell death 4 loss increases tumor cell invasion and is regulated by miR-21 in oral squamous cell carcinoma
    Patricia P Reis
    Division of Applied Molecular Oncology, Princess Margaret Hospital, Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada
    Mol Cancer 9:238. 2010
    The tumor suppressor Programmed Cell Death 4 (PDCD4) has been found to be under-expressed in several cancers and associated with disease progression and metastasis...
  40. pmc Structure of the tandem MA-3 region of Pdcd4 protein and characterization of its interactions with eIF4A and eIF4G: molecular mechanisms of a tumor suppressor
    Lorna C Waters
    Department of Biochemistry, Henry Wellcome Building, University of Leicester, Lancaster Road, Leicester LE1 9HN, United Kingdom
    J Biol Chem 286:17270-80. 2011
    ..The tumor suppressor protein Pdcd4 has been shown to inhibit cap-dependent translation by interacting tightly with the RNA helicase eIF4A via its ..
  41. doi Pdcd4 directly binds the coding region of c-myb mRNA and suppresses its translation
    P Singh
    Institute for Biochemistry, Westfalische Wilhelms Universitat Munster, Munster, Germany
    Oncogene 30:4864-73. 2011
    b>Pdcd4 is a novel tumor suppressor protein that functions in the nucleus and the cytoplasm, and appears to be involved in the regulation of transcription and translation...
  42. pmc Loss of programmed cell death 4 induces apoptosis by promoting the translation of procaspase-3 mRNA
    K Eto
    Department of Biological Sciences, Graduate School of Science and Technology, Kumamoto University, Japan
    Cell Death Differ 19:573-81. 2012
    The programmed cell death 4 (Pdcd4), a translation inhibitor, plays an essential role in tumor suppression, but its role in apoptosis remains unclear...
  43. pmc Tumor suppressor protein Pdcd4 inhibits translation of p53 mRNA
    Lena Wedeken
    Institut fur Biochemie, Westfalische Wilhelms Universitat Munster, D 48149 Munster, Germany
    J Biol Chem 286:42855-62. 2011
    The tumor suppressor protein Pdcd4 is thought to suppress translation of mRNAs containing structured 5'-UTRs by interacting with translation initiation factor eIF4A and inhibiting its helicase activity...
  44. doi Promoter cloning and characterization of the human programmed cell death protein 4 (pdcd4) gene: evidence for ZBP-89 and Sp-binding motifs as essential Pdcd4 regulators
    Jörg Hendrik Leupold
    Michigan Center for Translational Medicine, University of Michigan, Ann Arbor, MI, USA
    Biosci Rep 32:281-97. 2012
    Pdcd4 (programmed cell death protein 4) is an important novel tumour suppressor inhibiting transformation, translation, invasion and intravasation, and its expression is down-regulated in several cancers...
  45. doi PDCD4 expression inversely correlated with miR-21 levels in gastric cancers
    Zhang Cao
    Department of Pathology, College of Medicine, The Catholic University of Korea, 505 Banpo Dong, Seocho Gu, Seoul 137 701, Korea
    J Cancer Res Clin Oncol 138:611-9. 2012
    The specific aim of this study was to investigate whether the PDCD4 gene is involved in the development and progression of gastric cancer.
  46. pmc Tumour suppressive function and modulation of programmed cell death 4 (PDCD4) in ovarian cancer
    Na Wei
    Department of Obstetrics and Gynaecology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, Hong Kong
    PLoS ONE 7:e30311. 2012
    Programmed cell death 4 (PDCD4), originally identified as the neoplastic transformation inhibitor, was attenuated in various cancer types...
  47. pmc Tumor suppressor PDCD4 represses internal ribosome entry site-mediated translation of antiapoptotic proteins and is regulated by S6 kinase 2
    Urszula Liwak
    Apoptosis Research Centre, Children s Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada
    Mol Cell Biol 32:1818-29. 2012
    ..We now show that the FGF-2-S6K2 prosurvival signaling is mediated by the tumor suppressor programmed cell death 4 (PDCD4)...
  48. pmc Regulatory effects of programmed cell death 4 (PDCD4) protein in interferon (IFN)-stimulated gene expression and generation of type I IFN responses
    Barbara Kroczynska
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School and Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, USA
    Mol Cell Biol 32:2809-22. 2012
    ..We provide evidence that IFN-α induces phosphorylation of programmed cell death 4 (PDCD4) protein on Ser67...
  49. doi PDCD4/miR-21 dysregulation in inflammatory bowel disease-associated carcinogenesis
    Kathrin Ludwig
    Department of Medicine DIMED, Surgical Pathology and Cytopathology Unit, University of Padua, Padua, Italy
    Virchows Arch 462:57-63. 2013
    ..The programmed cell death 4 (PDCD4) tumor suppressor gene is involved in sporadic colorectal oncogenesis, but scanty information is available on its ..
  50. doi MicroRNA-182 promotes cell growth, invasion, and chemoresistance by targeting programmed cell death 4 (PDCD4) in human ovarian carcinomas
    Yu Quan Wang
    Department of Gynecology, The Second Hospital of Tianjin Medical University, Tianjin, China
    J Cell Biochem 114:1464-73. 2013
    As an important tumor suppressor, programmed cell death 4 (PDCD4) influences transcription and translation of multiple genes, and modulates different signal transduction pathways...
  51. pmc Down-regulation of programmed cell death 4 leads to epithelial to mesenchymal transition and promotes metastasis in mice
    Qing Wang
    Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, KY 40536, USA
    Eur J Cancer 49:1761-70. 2013
    In this study, we demonstrated that knockdown of programmed cell death 4 (Pdcd4), a novel tumour suppressor, decreased the expressions of epithelial-specific proteins and increased the expressions of mesenchymal-specific proteins in ..
  52. pmc Tumor suppressor gene PDCD4 negatively regulates autophagy by inhibiting the expression of autophagy-related gene ATG5
    Xingguo Song
    Department of Immunology, Shandong University, School of Medicine, Shangdong, China
    Autophagy 9:743-55. 2013
    PDCD4 (programmed cell death protein 4), a suppressor of gene transcription and translation, plays a crucial inhibitory role in several types of human tumors. However, its underlying mechanisms remain unclear...
  53. pmc Tumor suppressor protein Pdcd4 interacts with Daxx and modulates the stability of Daxx and the Hipk2-dependent phosphorylation of p53 at serine 46
    N Kumar
    1 Institut für Biochemie, Westfalische Wilhelms Universitat Munster, Munster, Germany 2 Graduate School of Chemistry GSC MS, Westfalische Wilhelms Universitat Munster, Germany
    Oncogenesis 2:e37. 2013
    The tumor suppressor protein Pdcd4 is a nuclear/cytoplasmic shuttling protein that has been implicated in the development of several types of human cancer...
  54. pmc miR-21 represses Pdcd4 during cardiac valvulogenesis
    Heather J Kolpa
    Cardiovascular Research Center, Cardiology Division, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Development 140:2172-80. 2013
    ..b>PDCD4 knockdown alone was sufficient to enhance endothelial cell migration...
  55. doi Downregulation of programmed cell death 4 (PDCD4) in tumorigenesis and progression of human digestive tract cancers
    Gang Ma
    Department of Surgery, First Affiliated Hospital, China Medical University, Shenyang, People s Republic of China
    Tumour Biol 34:3879-85. 2013
    ..The development of diagnosis and therapy is urgently required. Programmed cell death 4 (PDCD4), a new tumor suppressor, has been documented to be a potential diagnostic tool and treatment target for neoplasia ..
  56. doi Downregulation of microRNA-182 inhibits cell growth and invasion by targeting programmed cell death 4 in human lung adenocarcinoma cells
    Min Wang
    Department of Respiratory Medicine, People s Hospital of Zhengzhou, Zhengzhou, 450053, China
    Tumour Biol 35:39-46. 2014
    Lung cancer is a major cause of cancer death worldwide. Programmed cell death 4 (PDCD4), an important tumor suppressor, influences transcription and translation of multiple genes and modulates different signal transduction pathways...
  57. pmc Tumor suppressor PDCD4 modulates miR-184-mediated direct suppression of C-MYC and BCL2 blocking cell growth and survival in nasopharyngeal carcinoma
    Yan Zhen
    1 Department of Pathology, Basic School, Guangzhou Medical University, Guangzhou 510182, PR China 2 Cancer Research Institute, Southern Medical University, Guangzhou 510515, PR China 3 Institute of Respiratory Diseases, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524000, PR China
    Cell Death Dis 4:e872. 2013
    Programmed cell death 4 (PDCD4), a novel tumor suppressor, inhibits cell proliferation, migration and invasion as well as promotes cell apoptosis in tumors...
  58. doi Control of a tumor suppressor PDCD4: Degradation mechanisms of the protein in hepatocellular carcinoma cells
    Sachiko Matsuhashi
    Department of Internal Medicine, Saga Medical School, Saga University, Japan Electronic address
    Cell Signal 26:603-10. 2014
    ..TGF-β1 up-regulates the expression of PDCD4 causing apoptosis, by stimulating the synthesis of PDCD4 mRNA via the Smad signaling pathway...
  59. pmc Tumor suppressor PDCD4 inhibits NF-κB-dependent transcription in human glioblastoma cells by direct interaction with p65
    Soon Kyung Hwang
    Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, Frederick National Laboratory, 1050 Boyles Street, Bldg 576, Rm 101, Frederick, MD 21702, USA
    Carcinogenesis 35:1469-80. 2014
    b>PDCD4 is a tumor suppressor induced by apoptotic stimuli that regulates both translation and transcription...
  60. ncbi PDCD4 as a predictor of sensitivity to neoadjuvant chemoradiotherapy in locally advanced rectal cancer patients
    Xue Dou
    Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, University of Jinan, Jinan, China E mail
    Asian Pac J Cancer Prev 15:825-30. 2014
    The purpose of this study was to examine the role of programmed cell death 4 (PDCD4) expression in predicting tumor response to neoadjuvant chemoradiotherapy and outcomes for patients with locally advanced rectal cancer.
  61. ncbi Assignment of the programmed cell death 4 gene (PDCD4) to human chromosome band 10q24 by in situ hybridization
    H Soejima
    Department of Biochemistry, Saga Medical School, Nagasaki University School of Medicine, Japan
    Cytogenet Cell Genet 87:113-4. 1999
  62. ncbi Up-regulation of PDCD4 in senescent human diploid fibroblasts
    Min Ji Kang
    Department of Biochemistry and Molecular Biology and Ilchun Molecular Medicine Institute, Seoul National University College of Medicine, 28 Yongondong, Chongnogu, Seoul 110 799, Republic of Korea
    Biochem Biophys Res Commun 293:617-21. 2002
    Programmed cell death 4 (PDCD4) has a common MI domain sharing with death associated protein 5 (DAP5) and a component of eukaryotic translation initiation factor (eIF4G) complex and it might also work as a tumor suppressor...
  63. pmc Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion
    Hsin Sheng Yang
    Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
    Mol Cell Biol 26:1297-306. 2006
    Programmed cell death 4 (Pdcd4) suppresses neoplastic transformation by inhibiting the activation of c-Jun and consequently AP-1-dependent transcription...
  64. doi Translation inhibitor Pdcd4 is targeted for degradation during tumor promotion
    Tobias Schmid
    Laboratory of Cancer Prevention, National Cancer Institute, Frederick, MD 21702, USA
    Cancer Res 68:1254-60. 2008
    ..The translation inhibitor programmed cell death 4 (Pdcd4) suppresses tumorigenesis and invasion...
  65. pmc Programmed cell death 4 inhibits breast cancer cell invasion by increasing tissue inhibitor of metalloproteinases-2 expression
    Rene Nieves-Alicea
    Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Unit 422, Houston, TX 77030, USA
    Breast Cancer Res Treat 114:203-9. 2009
    ..that PGE(2) and IL-8 decreased the expression of the tumor suppressor protein Programmed Cell Death 4 (PDCD4). We hypothesized that suppression of PDCD4 expression is vital to the invasive activity of PGE(2) and IL-8...
  66. doi Knockdown of Pdcd4 results in induction of proprotein convertase 1/3 and potent secretion of chromogranin A and secretogranin II in a neuroendocrine cell line
    Brigitte Lankat-Buttgereit
    Faculty of Medicine, Department of Gastroenterology, Endocrinology and Metabolism, University of Marburg, Baldingerstrasse, D 35033 Marburg, Germany
    Biol Cell 100:703-15. 2008
    b>Pdcd4 (programmed cell death 4) is up-regulated during apoptosis and seems to play an important role as a tumour suppressor...
  67. doi PDCD4 inhibits the malignant phenotype of ovarian cancer cells
    Zeng Tao Wei
    Institute of Immunology, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital, Jinan, China
    Cancer Sci 100:1408-13. 2009
    Programmed cell death 4 (PDCD4) is a newly identified tumor suppressor that can inhibit activator protein (AP)-1 activation and protein translation...
  68. doi Programmed cell death 4 (PDCD4) enhances the sensitivity of gastric cancer cells to TRAIL-induced apoptosis by inhibiting the PI3K/Akt signaling pathway
    Wei Qiang Wang
    Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing, China
    Mol Diagn Ther 14:155-61. 2010
    ..The mechanisms underlying this resistance are unclear. The aim of this study was to explore the role of programmed cell death 4 (PDCD4) in regulating TRAIL sensitivity in gastric cancer cells.
  69. doi Expression of programmed cell death protein 4 (PDCD4) and miR-21 in urothelial carcinoma
    Nicolas Fischer
    Department of Urology, University of Bonn, Bonn, Germany
    Biochem Biophys Res Commun 417:29-34. 2012
    We investigated the role of the programmed cell death 4 (PDCD4) tumor suppressor gene in specimens of transitional cell carcinoma and of healthy individuals.
  70. pmc Pdcd4 knockdown up-regulates MAP4K1 expression and activation of AP-1 dependent transcription through c-Myc
    Qing Wang
    Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, KY 40536, USA
    Biochim Biophys Acta 1823:1807-14. 2012
    Programmed cell death 4 (Pdcd4) is a novel tumor suppressor, whose expression is frequently down-regulated in several types of cancers...
  71. ncbi Involvement of programmed cell death 4 in transforming growth factor-beta1-induced apoptosis in human hepatocellular carcinoma
    H Zhang
    Department of Internal Medicine, Division of Hepatology and Metabolism, Saga Medical School, Saga University, Saga, Japan
    Oncogene 25:6101-12. 2006
    The programmed cell death 4 (PDCD4) gene was originally identified as a tumor-related gene in humans and acts as a tumor-suppressor in mouse epidermal carcinoma cells...
  72. ncbi Programmed cell death protein 4 (PDCD4) acts as a tumor suppressor in neuroendocrine tumor cells
    Rüdiger Göke
    Clinical Research Unit for Gastrointestinal Endocrinology, University of Marburg, Marburg, Germany
    Ann N Y Acad Sci 1014:220-1. 2004
    b>PDCD4 is a new tumor suppressor gene. In the current study, we show that overexpression of PDCD4 in carcinoid cells results in inhibition of cell proliferation...
  73. doi Pdcd4 protein and mRNA level alterations do not correlate in human lung tumors
    Svetlana V Kalinichenko
    Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia
    Lung Cancer 62:173-80. 2008
    b>Pdcd4 (programmed cell death 4) gene is tumor suppressor which expression is frequently down-regulated in tumors, which is considered as a diagnostic and prognostic marker as well as promising target for anti-cancer therapy...
  74. pmc MicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3
    Florin M Selaru
    Division of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    Hepatology 49:1595-601. 2009
    ..995. Inhibitors of miR-21 increased protein levels of programmed cell death 4 (PDCD4) and tissue inhibitor of metalloproteinases 3 (TIMP3)...
  75. doi MicroRNA-21 regulates the proliferation and invasion in esophageal squamous cell carcinoma
    Yukiharu Hiyoshi
    Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Clin Cancer Res 15:1915-22. 2009
    ..The aim of this study was (a) to determine a role of microRNA-21 in esophageal squamous cell carcinoma and (b) to elucidate the regulation of the programmed cell death 4 (PDCD4) gene by microRNA-21.
  76. pmc microRNA 21: response to hormonal therapies and regulatory function in leiomyoma, transformed leiomyoma and leiomyosarcoma cells
    Qun Pan
    Department of Ob Gyn, University of Florida, Box 100294, Gainesville, FL 32610, USA
    Mol Hum Reprod 16:215-27. 2010
    ..in differential expression of many genes, including some of the miR-21-predicted/validated target genes, PTEN, PDCD4 and E2F1, and TGF-betaRII, in a cell-specific manner...
  77. pmc Cholesteatoma growth and proliferation: posttranscriptional regulation by microRNA-21
    David R Friedland
    Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Otol Neurotol 30:998-1005. 2009
    ..The goal of this study was to identify novel regulatory mechanisms controlling the growth and proliferation of cholesteatoma. Specifically, the potential role of microRNAs, regulators of protein translation, was studied in cholesteatoma...
  78. pmc Expression of miR-21 and its targets (PTEN, PDCD4, TM1) in flat epithelial atypia of the breast in relation to ductal carcinoma in situ and invasive carcinoma
    Liqiang Qi
    Department of Pathology and Medical Biology, Groningen University Medical Centre and University of Groningen, Groningen, The Netherlands
    BMC Cancer 9:163. 2009
    ..So far, miRNA expression changes associated with invasive breast cancer, like miR-21, have not been studied in FEA...
  79. pmc A network model of a cooperative genetic landscape in brain tumors
    Markus Bredel
    Department of Neurological Surgery, Northwestern Brain Tumor Institute and Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 3015, USA
    JAMA 302:261-75. 2009
    ..A persistent question concerns the biological basis for the coselection of these alterations during gliomagenesis...
  80. ncbi Characterization of programmed cell death 4 in multiple human cancers reveals a novel enhancer of drug sensitivity
    Aaron P Jansen
    Gene Regulation Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Mol Cancer Ther 3:103-10. 2004
    Programmed cell death 4 (Pdcd4), originally identified as an inhibitor of murine cellular transformation, inhibits protein synthesis by directly interacting with eukaryotic initiation factor 4A (eIF4A) of the translation initiation ..
  81. doi Expression of mutated IGHV3-23 genes in chronic lymphocytic leukemia identifies a disease subset with peculiar clinical and biological features
    Riccardo Bomben
    Clinical and Experimental Onco Hematology Unit, Centro di Riferimento Oncologico, I R C C S, Aviano PN, Italy
    Clin Cancer Res 16:620-8. 2010
    ..Here we investigated novel associations between usage of specific IGHV genes and clinical features in CLL...
  82. pmc Decreased level of PDCD4 (programmed cell death 4) protein activated cell proliferation in the lung of A/J mouse
    Soon Kyung Hwang
    Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University, Seoul, Korea
    J Aerosol Med Pulm Drug Deliv 23:285-93. 2010
    Programmed cell death 4 (PDCD4), a protein that binds to eukaryotic initiation factor 4A (eIF4A), inhibits the initiation of translation...
  83. pmc The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation
    Hsin Sheng Yang
    Gene Regulation Section, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, USA
    Mol Cell Biol 23:26-37. 2003
    b>Pdcd4 is a novel transformation suppressor that inhibits tumor promoter-induced neoplastic transformation and the activation of AP-1-dependent transcription required for transformation...
  84. pmc PDCD4 gene silencing in gliomas is associated with 5'CpG island methylation and unfavourable prognosis
    Fei Gao
    Department of Immunology, School of Medicine, Shandong University, Jinan, Shandong, China
    J Cell Mol Med 13:4257-67. 2009
    Programmed cell death 4 (PDCD4) is a newly described tumour suppressor that inhibits oncogenesis by suppressing gene transcription and translation...
  85. pmc MicroRNA-21 protects against the H(2)O(2)-induced injury on cardiac myocytes via its target gene PDCD4
    Yunhui Cheng
    RNA and Cardiovascular Research Laboratory, Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07101 1709, USA
    J Mol Cell Cardiol 47:5-14. 2009
    ..Programmed cell death 4 (PDCD4) that was regulated by miR-21 and was a direct target of miR-21 in cardiac myocytes...
  86. ncbi Pdcd4 suppresses tumor phenotype in JB6 cells by inhibiting AP-1 transactivation
    Hsin Sheng Yang
    Gene Regulation Section, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
    Oncogene 22:3712-20. 2003
    Transformation suppressor Pdcd4 is downregulated in transformed (Tx) mouse epidermal JB6 RT101 cells relative to transformation-resistant (P-) and susceptible (P+) variants...
  87. ncbi Programmed cell death-4 tumor suppressor protein contributes to retinoic acid-induced terminal granulocytic differentiation of human myeloid leukemia cells
    Bulent Ozpolat
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cancer Res 5:95-108. 2007
    Programmed cell death-4 (PDCD4) is a recently discovered tumor suppressor protein that inhibits protein synthesis by suppression of translation initiation...
  88. ncbi Expression patterns of programmed cell death 4 protein in normal human skin and some representative skin lesions
    Sachiko Matsuhashi
    Division of Hepatology and Metabolism, Department of Internal Medicine, Saga Medical School, Saga University, Saga, Japan
    Exp Dermatol 16:179-84. 2007
    Expression of a tumor suppressor gene, programmed cell death 4 (PDCD4), was investigated at the protein level in the human skin...
  89. doi Anti-miR-21 oligonucleotide sensitizes leukemic K562 cells to arsenic trioxide by inducing apoptosis
    Yumin Li
    Department of Biochemistry, Medical College of Jinan University, Guangzhou, China
    Cancer Sci 101:948-54. 2010
    ..Furthermore, dual-luciferase reporter vector, containing two tandem miR-21 binding sites from PDCD4 3'UTR, validated that PDCD4 was directly regulated by miR-21...
  90. ncbi Pdcd4 inhibits growth of tumor cells by suppression of carbonic anhydrase type II
    B Lankat-Buttgereit
    Clinical Research Unit for Gastrointestinal Endocrinology, University of Marburg, Baldingerstrasse, 35033 Marburg, Germany
    Mol Cell Endocrinol 214:149-53. 2004
    To identify new genes that are upregulated during apoptosis we previously cloned rat pdcd4. While the role of pdcd4 is still unclear it seems to possess a tumor suppressor activity...
  91. doi Development of LanthaScreen cellular assays for key components within the PI3K/AKT/mTOR pathway
    Coby B Carlson
    Invitrogen Discovery Sciences, Madison, Wisconsin 53719, USA
    J Biomol Screen 14:121-32. 2009
    ..are highlighted: Ser183 and Thr246 on the proline-rich AKT substrate 40 kDa (PRAS40), Ser457 on programmed cell death protein 4 (PDCD4), and Thr308 and Ser473 on AKT...
  92. doi BMP-6 inhibits microRNA-21 expression in breast cancer through repressing deltaEF1 and AP-1
    Jun Du
    Laboratory of Medical Molecular Biology, Medical College of Nankai University, 94 Weijin Road, Tianjin 300071, China
    Cell Res 19:487-96. 2009
    ..We also demonstrated that BMP-6-induced downregulation of miR-21 modified the activity of PDCD4 3'UTR and inhibited MDA-MB-231 cell invasion...
  93. pmc Resveratrol modulates the levels of microRNAs targeting genes encoding tumor-suppressors and effectors of TGFβ signaling pathway in SW480 cells
    Esmerina Tili
    Ohio State University, Department of Molecular Virology, Immunology and Medical Genetics, Columbus, OH 43210, USA
    Biochem Pharmacol 80:2057-65. 2010
    ..cytoplasmic RNase III producing mature microRNAs from their immediate precursors, tumor-suppressor factors such as PDCD4 or PTEN, as well as key effectors of the TGFβ signaling pathway, while increasing the levels of miR-663, a tumor-..
  94. ncbi [Study on the sensitivity of leukemic cells to arsenic trioxide enhanced by targeted suppression of mIRNA-21]
    Yu min Li
    Department of Biochemistry and Molecular Biology, Medical College of Jinan University, College of Jinan University, Guangzhou
    Zhongguo Zhong Xi Yi Jie He Za Zhi 30:170-3. 2010
    ..To study the effect of antisense oligonucleotide targeted on miRNA-21 (AMO-miR-21) for enhancing the arsenic trioxide (As2O3) sensitivity of leukemic K562 cells and its possible acting mechanism...
  95. ncbi Epidermal expression of the translation inhibitor programmed cell death 4 suppresses tumorigenesis
    Aaron P Jansen
    Gene Regulation Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, USA
    Cancer Res 65:6034-41. 2005
    Programmed cell death 4 (Pdcd4) is a novel repressor of in vitro transformation. Pdcd4 directly inhibits the helicase activity of eukaryotic translation initiation factor 4A, a component of the translation initiation complex...
  96. ncbi Frequent loss of PDCD4 expression in human glioma: possible role in the tumorigenesis of glioma
    Fei Gao
    Institute of Immunology, School of Medicine, Qilu Hospital, Shangdong University, Shandong, 44 Wenhua Xilu, Jinan 250021, P R China
    Oncol Rep 17:123-8. 2007
    Programmed cell death 4 (PDCD4) was recently identified as a novel tumor suppressor gene. The loss of PDCD4 expression was found in several types of human cancer cell lines...
  97. ncbi Aerosol-delivered programmed cell death 4 enhanced apoptosis, controlled cell cycle and suppressed AP-1 activity in the lungs of AP-1 luciferase reporter mice
    S K Hwang
    Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University, Seoul, Korea
    Gene Ther 14:1353-61. 2007
    ..In this study, glucosylated polyethylenimine (GPEI) was used as carrier to investigate programmed cell death 4 (PDCD4) and PDCD4 mutant (D418A), an eIF4A-binding mutant, on PDCD4-related signaling and activator protein-1 (AP-1) ..
  98. ncbi MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer
    I A Asangani
    Department of Experimental Surgery and Molecular Oncology of Solid Tumors, Medical Faculty Mannheim, University of Heidelberg, Germany
    Oncogene 27:2128-36. 2008
    Tumor-suppressor Pdcd4 inhibits transformation and invasion and is downregulated in cancers. So far, it has not been studied as to whether miRNAs, suppressing target expression by binding to the 3'-UTR, regulate Pdcd4 or invasion...
  99. pmc Programmed cell death 4 (PDCD4) suppresses metastastic potential of human hepatocellular carcinoma cells
    Shuhong Zhang
    Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong University324 Jingwu Weiqi Road, Jinan 250021, PR China
    J Exp Clin Cancer Res 28:71. 2009
    ..There are no effective managements to block metastasis of HCC. Programmed cell death 4 (PDCD4) is found to be a tumor transformation suppressor...
  100. pmc Development of a high-throughput cell-based reporter assay to identify stabilizers of tumor suppressor Pdcd4
    Johanna S Blees
    Institute of Biochemistry I, Goethe University Frankfurt am Main, Frankfurt, Germany
    J Biomol Screen 15:21-9. 2010
    The novel tumor suppressor Pdcd4 affects tumorigenesis by inhibiting translation. Pdcd4 is phosphorylated and subsequently lost by proteasomal degradation in response to tumor-promoting conditions...
  101. pmc An essential role of PDCD4 in vascular smooth muscle cell apoptosis and proliferation: implications for vascular disease
    Xiaojun Liu
    Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA
    Am J Physiol Cell Physiol 298:C1481-8. 2010
    ..In the current study, we have found that programmed cell death 4 (PDCD4) is significantly downregulated in balloon-injured rat carotid arteries in vivo and in platelet-derived growth ..

Research Grants15

  1. Role of miRNAs in Vascular Physiology
    Akiko Hata; Fiscal Year: 2012
    ..Induction of miR-21 in PASMCs leads to downregulation of Programmed Cell Death 4 (PDCD4) which in turn leads to the elevation of VSMC-specific gene expression...
  2. Gang Liu; Fiscal Year: 2015
    ..Target predictions as well as previous studies demonstrate that miR-21 regulates the expression of PDCD4, Smad7, Spry1, and PTEN...
  3. Asim B Abdel-Mageed; Fiscal Year: 2015
    ..miR-155) and oncogenic mRNAs (H-Ras and K-Ras), which in turn down-regulated several key tumor suppressors (TP53, PDCD4 and Lats2) in pASCs...
  4. Michele Pagano; Fiscal Year: 2016
    ..For example, we found that: the translation inhibitor Pdcd4 and the pro-apoptotic protein BimEL are degraded in a [unreadable]TrCP-dependent manner in response to growth and ..
  5. The Effect of Diet and Nutrients on the Progression and Treatment of Prostate Can
    George Thomas; Fiscal Year: 2013
    ..pathway, which is opposed by a large number of tumor suppressors including PTEN, TSC1/2, NF1, LKB1, 4E-BP1, PDCD4, and PML...
  6. TGF-Beta signaling and microRNA processing: Implications for invasion and metasta
    ANA CLARA PEREIRA AZEVEDO-POULY; Fiscal Year: 2012
    ..g. TIMP3, PDCD4, RECK and maspin)...
  7. The role of Pdcd4 in colorectal tumor progression
    Hsin Sheng Yang; Fiscal Year: 2013
    ..Over- expression of programmed cell death 4 (Pdcd4), a novel tumor suppressor, inhibits invasion and AP-1 dependent transcription in colon tumor cells...
  8. Leonidas C Platanias; Fiscal Year: 2016
    ..JAK2V617F mouse models will be established in AKT -/-, S6K -/- and Pdcd4 -/- KO mice, and the ability of IFN[unreadable] to induce antileukemic responses in vivo, in the presence or ..
  9. Leonard S Jefferson; Fiscal Year: 2015
    ..as selected novel regulatory mechanisms that mediate control of protein synthesis, including truncated 4E-BP1 and PDCD4. We will also define the regulation and function of two previously identified potential therapeutic targets for ..
  10. Katharine S Ullman; Fiscal Year: 2014
    ..mRNA co-expression of the protein methyltransferase PRMT5 and a newly-discovered target of this enzyme, PDCD4, corresponds to poor prognosis in breast cancer...
  11. CD44-P185HER2 INTERACTION IN OVARIAN CANCER PROGRESSION
    LILLY BOURGUIGNON; Fiscal Year: 2007
    ..abstract_text> ..
  12. CD44/VARIANT CYTOSKELETON IN BREAST CANCER PROGRESSION
    LILLY YW BOURGUIGNON; Fiscal Year: 2010
    ....
  13. Mechanisms of Chemoprevention by Resveratrol
    Rakesh Srivastava; Fiscal Year: 2009
    ..Thus, resveratrol based strategies can be utilized for prevention and treatment of prostate cancer, and in the long-term it may have profound impact on the overall incidence of human prostate cancer. ..
  14. NanoArrays in Mass Spectrometry for Proteomic and Metabolomic Applications
    Daojing Wang; Fiscal Year: 2008
    ..Towards this goal, we propose to utilize the enormous potential of nanotechnology to develop novel ionization substrates for mass spectrometry to study proteins and metabolites of single stem cells. [unreadable] [unreadable] [unreadable]..
  15. Differential Gene Expression in the Cochlear Nucleus
    David Friedland; Fiscal Year: 2008
    ..These data will also provide a powerful template upon which to test and design novel treatments for improving hearing, discrimination and tinnitus in a significant portion of the population. ..