PDCD1

Summary

Gene Symbol: PDCD1
Description: programmed cell death 1
Alias: CD279, PD-1, PD1, SLEB2, hPD-1, hPD-l, hSLE1, programmed cell death protein 1, programmed cell death 1 protein, protein PD-1, systemic lupus erythematosus susceptibility 2
Species: human

Top Publications

  1. doi PD-1 and its ligands in tolerance and immunity
    Mary E Keir
    Department of Pathology, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115 5727, USA
    Annu Rev Immunol 26:677-704. 2008
  2. pmc PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis
    Xin Huang
    Division of Surgical Research, Department of Surgery, Brown University School of Medicine Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, USA
    Proc Natl Acad Sci U S A 106:6303-8. 2009
  3. doi Circulating precursor CCR7(lo)PD-1(hi) CXCR5⁺ CD4⁺ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure
    Jing He
    Department of Rheumatology and Immunology, Peking University People s Hospital, Beijing 100044, China
    Immunity 39:770-81. 2013
  4. pmc Human circulating PD-1+CXCR3-CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses
    Michela Locci
    Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92037, USA
    Immunity 39:758-69. 2013
  5. doi A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application
    Taku Okazaki
    Division of Immune Regulation, Institute for Genome Research, University of Tokushima, Tokushima, Japan
    Nat Immunol 14:1212-8. 2013
  6. pmc CD160 and PD-1 co-expression on HIV-specific CD8 T cells defines a subset with advanced dysfunction
    Yoav Peretz
    Caprion ImmuneCarta Services, Montreal, Quebec, Canada
    PLoS Pathog 8:e1002840. 2012
  7. doi PD-1/PD-L1 interactions contribute to functional T-cell impairment in patients who relapse with cancer after allogeneic stem cell transplantation
    Wieger J Norde
    Departments of Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Cancer Res 71:5111-22. 2011
  8. pmc Evidence for a role of the PD-1:PD-L1 pathway in immune resistance of HPV-associated head and neck squamous cell carcinoma
    Sofia Lyford-Pike
    Department of Otolaryngology Head and Neck Surgery, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
    Cancer Res 73:1733-41. 2013
  9. doi Recent insights into the role of the PD-1/PD-L1 pathway in immunological tolerance and autoimmunity
    Elena Gianchecchi
    Autoimmunity Laboratory, Immunology Area, Bambino Gesu Children s Hospital IRCCS, Rome, Italy
    Autoimmun Rev 12:1091-100. 2013
  10. doi Drug of the year: programmed death-1 receptor/programmed death-1 ligand-1 receptor monoclonal antibodies
    Caroline Robert
    Gustave Roussy Comprehensive Cancer Center, 114 rue Edouard Vaillant, 94800 Villejuif Paris Sud, France
    Eur J Cancer 49:2968-71. 2013

Research Grants

  1. Esteban Celis; Fiscal Year: 2016
  2. LI LILY WANG; Fiscal Year: 2016
  3. Lishan Su; Fiscal Year: 2016
  4. George F Murphy; Fiscal Year: 2016
  5. Defining the Pathogenesis of Immune Deficiency in Chronic HIV Infection
    MICHAEL MARCEL LEDERMAN; Fiscal Year: 2012
  6. Cellular Immunity and the Outcome of Hepatitis C Virus Infection
    Kyong Mi Chang; Fiscal Year: 2010
  7. LH ACTION IN OVARIAN CELL DIFFERENTIATION
    JoAnne S Richards; Fiscal Year: 2013
  8. COSTIMULATORY PATHWAYS IN SENSITIZED GRAFT RECIPIENTS
    Jerzy Kupiec Weglinski; Fiscal Year: 2009
  9. Domenico Accili; Fiscal Year: 2016
  10. Role and mechanism of negative costimulatory pathways in EAE
    Samia J Khoury; Fiscal Year: 2010

Detail Information

Publications235 found, 100 shown here

  1. doi PD-1 and its ligands in tolerance and immunity
    Mary E Keir
    Department of Pathology, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115 5727, USA
    Annu Rev Immunol 26:677-704. 2008
    ..In this review, we discuss current understanding of the immunoregulatory functions of PD-1 and its ligands and their therapeutic potential...
  2. pmc PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis
    Xin Huang
    Division of Surgical Research, Department of Surgery, Brown University School of Medicine Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, USA
    Proc Natl Acad Sci U S A 106:6303-8. 2009
    ....
  3. doi Circulating precursor CCR7(lo)PD-1(hi) CXCR5⁺ CD4⁺ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure
    Jing He
    Department of Rheumatology and Immunology, Peking University People s Hospital, Beijing 100044, China
    Immunity 39:770-81. 2013
    ..Therefore, circulating CCR7(lo)PD-1(hi) CXCR5⁺ CD4⁺ T cells are generated during active Tfh differentiation and represent a new mechanism of immunological early memory...
  4. pmc Human circulating PD-1+CXCR3-CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses
    Michela Locci
    Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92037, USA
    Immunity 39:758-69. 2013
    ..Importantly, the frequency of these cells correlated with the development of bnAbs against HIV in a large cohort of HIV⁺ individuals...
  5. doi A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application
    Taku Okazaki
    Division of Immune Regulation, Institute for Genome Research, University of Tokushima, Tokushima, Japan
    Nat Immunol 14:1212-8. 2013
    ..Such unique properties make PD-1 a powerful target for immunological therapy, with highly effective clinical applications for cancer treatment. ..
  6. pmc CD160 and PD-1 co-expression on HIV-specific CD8 T cells defines a subset with advanced dysfunction
    Yoav Peretz
    Caprion ImmuneCarta Services, Montreal, Quebec, Canada
    PLoS Pathog 8:e1002840. 2012
    ....
  7. doi PD-1/PD-L1 interactions contribute to functional T-cell impairment in patients who relapse with cancer after allogeneic stem cell transplantation
    Wieger J Norde
    Departments of Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Cancer Res 71:5111-22. 2011
    ..Furthermore, they suggest that blocking the PD-1 immune checkpoint offers an appealing immunotherapeutic strategy following alloSCT in patients with recurrent or relapsed disease...
  8. pmc Evidence for a role of the PD-1:PD-L1 pathway in immune resistance of HPV-associated head and neck squamous cell carcinoma
    Sofia Lyford-Pike
    Department of Otolaryngology Head and Neck Surgery, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
    Cancer Res 73:1733-41. 2013
    ....
  9. doi Recent insights into the role of the PD-1/PD-L1 pathway in immunological tolerance and autoimmunity
    Elena Gianchecchi
    Autoimmunity Laboratory, Immunology Area, Bambino Gesu Children s Hospital IRCCS, Rome, Italy
    Autoimmun Rev 12:1091-100. 2013
    ..We finally speculate on the possible development of novel therapeutic treatments in human autoimmunity by modulating the PD-1/PD-L1 pathway. ..
  10. doi Drug of the year: programmed death-1 receptor/programmed death-1 ligand-1 receptor monoclonal antibodies
    Caroline Robert
    Gustave Roussy Comprehensive Cancer Center, 114 rue Edouard Vaillant, 94800 Villejuif Paris Sud, France
    Eur J Cancer 49:2968-71. 2013
    ..Because of all these reasons PD-1/PD-L1 antibodies are considered 'drug of the year'...
  11. pmc Programmed death-1 is a marker for abnormal distribution of naive/memory T cell subsets in HIV-1 infection
    Gaelle Breton
    Laboratoire d Immunologie, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Saint Luc, Montreal, Quebec H2X 1P1, Canada
    J Immunol 191:2194-204. 2013
    ..Our findings identify PD-1 as a marker for aberrant distribution of T cell subsets in HIV-1 infection. ..
  12. pmc Disabling immune tolerance by programmed death-1 blockade with pidilizumab after autologous hematopoietic stem-cell transplantation for diffuse large B-cell lymphoma: results of an international phase II trial
    Philippe Armand
    Philippe Armand and Edie Weller, Dana Farber Cancer Institute David E Avigan, Beth Israel Deaconess Medical Center Yi Bin Chen, Massachusetts General Hospital, Boston, MA Arnon Nagler, Chaim Sheba Medical Center, Tel Hashomer Reuven Or, Hadassah Medical Center, Jerusalem Rinat Rotem Yehudar, CureTech, Yavne, Israel Steven M Devine, The Ohio State University Comprehensive Cancer Center, Ohio State University, Columbus Hillard M Lazarus, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, OH Mark S Kaminski, University of Michigan, Ann Arbor, MI H Kent Holland, Northside Hospital Edmund K Waller, Winship Cancer Institute, Emory University, Atlanta, GA Jane N Winter and Leo I Gordon, Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine Stephanie A Gregory, Rush Medical Center, Chicago, IL James R Mason, Scripps Clinic Edward D Ball, Moores University of California at San Diego Cancer Center, University of California, San Diego John M Timmerman and David Andorsky, University of California, Los Angeles, Los Angeles, CA Joseph W Fay, Baylor Research Institute, Department of Internal Medicine
    J Clin Oncol 31:4199-206. 2013
    ..The reconstituting immune landscape after autologous hematopoietic stem-cell transplantation (AHSCT) may be particularly favorable for breaking immune tolerance through PD-1 blockade...
  13. pmc CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms
    Richard V Parry
    Abramson Family Cancer Research Institute, 556 BRB II III, 421 Curie Blvd, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Cell Biol 25:9543-53. 2005
    ..Together, these data suggest that CTLA-4 and PD-1 inhibit T-cell activation through distinct and potentially synergistic mechanisms...
  14. pmc Chronically inflamed livers up-regulate expression of inhibitory B7 family members
    Rachel Kassel
    Carter Immunology Center, Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA
    Hepatology 50:1625-37. 2009
    ..The degree of necroinflammation correlates with expression levels of PD-1 family members...
  15. pmc Responsiveness of HIV-specific CD4 T cells to PD-1 blockade
    Filippos Porichis
    Ragon Institute of MGH, MIT and Harvard, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Blood 118:965-74. 2011
    ..These data show that PD-1 impairs HIV-specific T helper responses both by limiting expansion of these cells and by inhibiting effector functions of multiple differentiated CD4 T-cell subsets...
  16. pmc Human type 1 and 17 responses in latent tuberculosis are modulated by coincident filarial infection through cytotoxic T lymphocyte antigen-4 and programmed death-1
    Subash Babu
    National Institutes of Health International Center for Excellence in Research, India
    J Infect Dis 200:288-98. 2009
    ....
  17. doi PD-1 expression on natural killer cells and CD8(+) T cells during chronic HIV-1 infection
    Sonia Norris
    Department of Immunology, Imperial College London, London, UK
    Viral Immunol 25:329-32. 2012
    ..Raised levels of PD-1 were associated with limited NK cell proliferation, which may have consequences for their maintenance during chronic HIV-1 infection...
  18. pmc PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection
    Constantinos Petrovas
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 203:2281-92. 2006
    ....
  19. ncbi T cell dysfunction by hepatitis C virus core protein involves PD-1/PDL-1 signaling
    Zhi Q Yao
    Department of Internal Medicine, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    Viral Immunol 20:276-87. 2007
    ..This upregulation of the PD-1 and PDL-1 pathway in humans represents a novel and perhaps common mechanism by which a virus usurps host machinery to facilitate persistence...
  20. ncbi PD-1 gene haplotype is associated with the development of type 1 diabetes mellitus in Japanese children
    Ronghua Ni
    Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashiku, Fukuoka 812 8582, Japan
    Hum Genet 121:223-32. 2007
    ..In conclusion, the genetic evaluation by association study demonstrated that the PD-1 gene was a predisposing gene to the development of T1D mellitus in the Japanese population...
  21. doi Cross-talk between programmed death-1 and suppressor of cytokine signaling-1 in inhibition of IL-12 production by monocytes/macrophages in hepatitis C virus infection
    Ying Zhang
    Department of Internal Medicine, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    J Immunol 186:3093-103. 2011
    ....
  22. pmc Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF
    Michael Quigley
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 16:1147-51. 2010
    ..Thus, inhibitory receptors can cause T cell exhaustion by upregulating genes--such as BATF--that inhibit T cell function. Such genes may provide new therapeutic opportunities to improve T cell immunity to HIV...
  23. pmc Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy
    Janis M Taube
    Departments of Dermatology, Pathology, Oncology, and
    Clin Cancer Res 20:5064-74. 2014
    ..Immunomodulatory drugs differ in mechanism-of-action from directly cytotoxic cancer therapies. Identifying factors predicting clinical response could guide patient selection and therapeutic optimization...
  24. pmc Programmed death-1 concentration at the immunological synapse is determined by ligand affinity and availability
    Tsvetelina Pentcheva-Hoang
    Howard Hughes Medical Institute, Department of Immunology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 104:17765-70. 2007
    ..PD-1 and CD28 have similar kinetics of synaptic accumulation, suggesting that the process involves T cell receptor-triggered cytoskeletal reorganization followed by ligand binding...
  25. doi PD-1 expression and IL-2 loss of cytomegalovirus- specific T cells correlates with viremia and reversible functional anergy
    U Sester
    Department of Internal Medicine IV, University of the Saarland, D 66421 Homburg, Germany
    Am J Transplant 8:1486-97. 2008
    ....
  26. doi Contributions of PD-1/PD-L1 pathway to interactions of myeloid DCs with T cells in atherosclerosis
    Jun Lee
    Department of Cardiology, Tangdu Hospital, Fourth Military Medical University, Baqiao District, Xi an 710038, P R China
    J Mol Cell Cardiol 46:169-76. 2009
    ....
  27. doi Germinal-center T-helper-cell markers PD-1 and CXCL13 are both expressed by neoplastic cells in angioimmunoblastic T-cell lymphoma
    Hongbo Yu
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Am J Clin Pathol 131:33-41. 2009
    ..The similar pattern of expression of CXCL13 and PD-1 in AITL provides further evidence that AITL is a neoplasm derived from germinal-center T-helper cells...
  28. doi Interactions between programmed death 1 (PD-1) and cytotoxic T lymphocyte antigen 4 (CTLA-4) gene polymorphisms in type 1 diabetes
    Scherezade Momin
    University of Michigan, Ann Arbor, MI, USA
    Diabetes Res Clin Pract 83:289-94. 2009
    ..To explore the contribution of the PD-1 gene polymorphisms involved in T1D as well as the relationship between the PD-1/CTLA-4 genes and soluble CTLA-4 concentrations...
  29. pmc Enhanced PD-1 expression by T cells in cerebrospinal fluid does not reflect functional exhaustion during chronic human immunodeficiency virus type 1 infection
    Shanmugalakshmi Sadagopal
    Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, TN 37203, USA
    J Virol 84:131-40. 2010
    ..As inhibition of the PD-1/PD-L1 pathway is pursued as a therapeutic option for viral infections, potential effects of such a blockade on development of autoimmune responses in the CNS should be considered...
  30. pmc Programmed death-1 receptor and interleukin-10 in liver transplant recipients at high risk for late cytomegalovirus disease
    A Krishnan
    Division of Translational Vaccine Research, Beckman Research Institute of the City of Hope, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA
    Transpl Infect Dis 12:363-70. 2010
    ..Our preliminary observations support further investigation of dual monitoring of PD-1 and IL-10, as potential immune markers of CMV disease...
  31. pmc Natural course of chronic hepatitis B is characterized by changing patterns of programmed death type-1 of CD8-positive T cells
    Xue Song Liang
    Department of Infectious Diseases, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
    World J Gastroenterol 16:618-24. 2010
    ..To investigate if and how programmed death type-1 (PD-1) expression affects the natural course of hepatitis B virus (HBV) infection...
  32. pmc PD-1 negatively regulates interleukin-12 expression by limiting STAT-1 phosphorylation in monocytes/macrophages during chronic hepatitis C virus infection
    Cheng J Ma
    Division of Infectious Diseases, Department of Internal Medicine, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Immunology 132:421-31. 2011
    ..These results suggest that the PD-1 inhibitory pathway may negatively regulate IL-12 expression by limiting STAT-1 phosphorylation in M/Mφ during chronic HCV infection...
  33. doi Progressive upregulation of PD-1 in primary and metastatic melanomas associated with blunted TCR signaling in infiltrating T lymphocytes
    Maxime Chapon
    Institut Cochin, INSERM, U1016, Paris, France
    J Invest Dermatol 131:1300-7. 2011
    ....
  34. pmc Immunostaining of PD-1/PD-Ls in liver tissues of patients with hepatitis and hepatocellular carcinoma
    Bao Ju Wang
    Division of Clinical Immunology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
    World J Gastroenterol 17:3322-9. 2011
    ..To investigate the expression of programmed death (PD)-1, PD ligand 1 (PD-L1) and PD-L2 in liver tissues in the context of chronic hepatitis and hepatocellular carcinoma (HCC)...
  35. pmc Phenotype, effector function, and tissue localization of PD-1-expressing human follicular helper T cell subsets
    Chuanwu Wang
    Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, Center for Cancer Research, Bindley Bioscience Center, Purdue University, West Lafayette, IN 47907, USA
    BMC Immunol 12:53. 2011
    ..We investigated the expression modality and function of PD-1 expressed by human T cells specialized in helping B cells...
  36. doi Genetic polymorphisms and surface expression of CTLA-4 and PD-1 on T cells of silica-exposed workers
    Michelle C Rocha
    Department of Pharmacology and Hemocenter, Faculty of Medical Sciences, FCM, State University of Campinas UNICAMP, Campinas, SP, Brazil
    Int J Hyg Environ Health 215:562-9. 2012
    ..molecules on the surface of CD4 and CD8 T cells, as well as single nucleotide polymorphisms (SNP) in CTLA-4 and PDCD1 genes, of 70 silica-exposed workers and 30 non-exposed, age-, ethnically- and sex-matched controls...
  37. doi PD-1 and its ligand PD-L1 are progressively up-regulated on CD4 and CD8 T-cells in HIV-2 infection irrespective of the presence of viremia
    Rita Tendeiro
    Unidade de Imunologia Clinica, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Clínica de Doenças Infecciosas, Hospital de Santa Maria, Lisboa, Portugal
    AIDS 26:1065-71. 2012
    ..Here we investigated, for the first time, inhibitory molecules in HIV-2 infection, a naturally occurring attenuated form of HIV disease, associated with reduced viremia and very slow rates of CD4 T-cell decline...
  38. pmc Programmed death-1 and its ligand are novel immunotolerant molecules expressed on leukemic B cells in chronic lymphocytic leukemia
    Maciej Grzywnowicz
    Department of Experimental Hematooncology, Medical University of Lublin, Lublin, Poland
    PLoS ONE 7:e35178. 2012
    ..PD-1, which is aberrantly expressed both at mRNA and cell surface levels in CLL cells might represent a novel immunotolerant molecule involved in the pathomechanism of the disease, and could provide a novel target for future therapies...
  39. doi Selective effects of PD-1 on Akt and Ras pathways regulate molecular components of the cell cycle and inhibit T cell proliferation
    Nikolaos Patsoukis
    Department of Hematology Oncology and Cancer Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Sci Signal 5:ra46. 2012
    ..Thus, PD-1 blocks cell cycle progression and proliferation of T lymphocytes by affecting multiple regulators of the cell cycle...
  40. doi Intrahepatic expression of programmed death-1 and its ligands in patients with HBV-related acute-on-chronic liver failure
    Dayan Cao
    Institute of Immunology, PLA, Third Military Medical University, Chongqing, 400038, People s Republic of China
    Inflammation 36:110-20. 2013
    ..Our combined results suggest that the expression of PD-L1 and PD-L2 may be biomarkers to identify and diagnose ACLF, and a clear understanding of their functional roles should further elucidate the pathogenesis of this disease...
  41. pmc Role of the PD-1 pathway in the immune response
    L V Riella
    Schuster Family Transplantation Research Center, Renal Division, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    Am J Transplant 12:2575-87. 2012
    ..In this review, we discuss the current knowledge of the immunoregulatory functions of PD-1 and its ligands and their therapeutic potential in transplantation...
  42. doi PD-1 regulates the growth of human mastocytosis cells
    Tatsuki R Kataoka
    Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan
    Allergol Int 62:99-104. 2013
    ..Programmed death-1 (PD-1) is a marker for human neoplastic T cells. Here, we evaluated whether or not PD-1 was also a marker for human mastocytosis, and explored the role of PD-1 in human mastocytosis cells...
  43. pmc The PD-1/PD-L1 axis contributes to T-cell dysfunction in chronic lymphocytic leukemia
    Davide Brusa
    Human Genetics Foundation HuGeF and Department of Medical Sciences, University of Turin, Turin, Italy
    Haematologica 98:953-63. 2013
    ..These observations suggest that pharmacological manipulation of the PD-1/PD-L1 axis may contribute to restoring T-cell functions in the chronic lymphocytic leukemia microenvironment...
  44. doi Prognostic significance of programmed cell death-1-positive cells in follicular lymphoma patients may alter in the rituximab era
    Hiroyuki Takahashi
    Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Eur J Haematol 90:286-90. 2013
    ..However, in male subgroup, high levels of PD-1-positive cells were found to be a prognostic factor for PFS. Addition of rituximab might have altered the prognostic impact of PD-1-positive cells...
  45. pmc Increased level of myeloid-derived suppressor cells, programmed death receptor ligand 1/programmed death receptor 1, and soluble CD25 in Sokal high risk chronic myeloid leukemia
    Lisa Christiansson
    Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden
    PLoS ONE 8:e55818. 2013
    ..These escape mechanisms should be monitored in trials to understand their importance and how to overcome the immune suppression...
  46. doi Inhibiting the programmed death 1 pathway rescues Mycobacterium tuberculosis-specific interferon γ-producing T cells from apoptosis in patients with pulmonary tuberculosis
    Amar Singh
    Department of Transplant Immunology and Immunogenetics, All India Institute of Medical Sciences, New Delhi, India
    J Infect Dis 208:603-15. 2013
    ..However, the precise mechanism of such inhibition remains unclear. The present study addresses the role of PD-1 in dampening host T-cell function among patients with pulmonary tuberculosis...
  47. pmc PD-1 increases PTEN phosphatase activity while decreasing PTEN protein stability by inhibiting casein kinase 2
    Nikolaos Patsoukis
    Department of Hematology Oncology and Cancer Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Mol Cell Biol 33:3091-8. 2013
    ..Our results identify CK2 as a new target of PD-1 and reveal an unexpected mechanism by which PD-1 decreases PTEN protein expression while increasing PTEN activity, thereby inhibiting the PI3K/Akt signaling axis. ..
  48. doi Peripheral CD45RO, PD-1, and TLR4 expression in metastatic colorectal cancer patients treated with bevacizumab, fluorouracil, and irinotecan (FOLFIRI-B)
    Vincenzo Formica
    Medical Oncology Unit, Tor Vergata Clinical Center, University of Rome, Rome, Italy
    Med Oncol 30:743. 2013
    ..drawn before the first and third cycle and analyzed by flow cytometry for frequency (%) of CD4+, CD8+, CD45RO+, and PD1+ mononuclear cells and for TLR4 expression on neutrophils...
  49. pmc Staphylococcus aureus convert neonatal conventional CD4(+) T cells into FOXP3(+) CD25(+) CD127(low) T cells via the PD-1/PD-L1 axis
    Hardis Rabe
    Department of Rheumatology and Inflammation Research, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    Immunology 141:467-81. 2014
    ..aureus possess an ability to convert neonatal conventional CD4(+) T cells into FOXP3(+) CD25(+) CD127(low) Treg cells via the PD-1/PD-L1 axis...
  50. doi Analysis of the functional relevance of a putative regulatory SNP of PDCD1, PD1.3, associated with systemic lupus erythematosus
    M Suarez-Gestal
    Laboratorio de Investigacion 2 and Rheumatology Unit, Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain
    Genes Immun 9:309-15. 2008
    ..Results were against the hypothesis that the PD1.3 locus acts as enhancer in transcriptional regulation of PDCD1. In addition, they excluded a differential effect of the PD1.3 alleles...
  51. pmc HIV-mediated phosphatidylinositol 3-kinase/serine-threonine kinase activation in APCs leads to programmed death-1 ligand upregulation and suppression of HIV-specific CD8 T cells
    Karuppiah Muthumani
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 187:2932-43. 2011
    ..These data identify a novel mechanism by which HIV exploits the immunosuppressive PD-1 pathway and suggest a new role for virus-infected cells in the local corruption of immune responses required for viral suppression...
  52. doi Follicular programmed death 1-positive lymphocytes in the tumor microenvironment are an independent prognostic factor in follicular lymphoma
    Bill G Richendollar
    Clinical Pathology, Institute of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
    Hum Pathol 42:552-7. 2011
    ..Future studies, performed prospectively on uniformly treated patient cohorts, should be performed to validate these findings...
  53. ncbi Role of an intronic polymorphism in the PDCD1 gene with the risk of sporadic systemic lupus erythematosus and the occurrence of antiphospholipid antibodies
    Dharambir K Sanghera
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Hum Genet 115:393-8. 2004
    Recently, a polymorphism in intron 4 (G/A) of the programmed cell death 1 ( PDCD1) gene was shown to be associated with systemic lupus erythematosus (SLE) risk in familial and sporadic patients of European, European American, and Mexican ..
  54. ncbi PD-1 up-regulation is correlated with HIV-specific memory CD8+ T-cell exhaustion in typical progressors but not in long-term nonprogressors
    Ji Yuan Zhang
    Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
    Blood 109:4671-8. 2007
    ..Blocking the PD-1/PD-L1 pathway may represent a new therapeutic option for this disease and provide more insight into immune pathogenesis in LTNPs...
  55. pmc Programmed death-1 upregulation is correlated with dysfunction of tumor-infiltrating CD8+ T lymphocytes in human non-small cell lung cancer
    Yan Zhang
    Department of Laboratory Diagnosis, Changhai Hospital, Second Military Medical University, Shanghai, China
    Cell Mol Immunol 7:389-95. 2010
    ..These data provide direct evidence that the PD-1/PD-L1 pathway is involved in CD8+ T-cell dysfunction in NSCLC patients. Moreover, blocking this pathway provides a potential therapy target in lung cancer...
  56. pmc Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction
    Shengdian Wang
    Department of Immunology, Mayo Graduate and Medical Schools, Mayo Clinic, Rochester, MN 55905, USA
    J Exp Med 197:1083-91. 2003
    ..Our results reveal unique binding characteristics of B7-H1 and B7-DC and provide direct evidence for an independent costimulatory receptor other than PD-1...
  57. ncbi Tag SNP screening of the PDCD1 gene for association with Graves' disease
    P R Newby
    Department of Medicine, Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham, UK
    Clin Endocrinol (Oxf) 67:125-8. 2007
    The Programmed Cell Death 1 gene (PDCD1) on chromosome 2q37.3 encodes PD-1 which is involved in providing a negative signal to activated T cells...
  58. ncbi A PD-1 polymorphism is associated with disease progression in multiple sclerosis
    Antje Kroner
    Clinical Research Group for Multiple Sclerosis and Neuroimmunology, Department of Neurology, Bayerische Julius Maximilians Universität, Wurzburg, Germany
    Ann Neurol 58:50-7. 2005
    ..In conclusion, our data suggest that PD-1 polymorphism is a genetic modifier of the progression of MS, possibly through inducing a partial defect in PD-1-mediated inhibition of T-cell activation...
  59. pmc Association of the programmed cell death 1 (PDCD1) gene polymorphism with ankylosing spondylitis in the Korean population
    Sang Hoon Lee
    Department of Rheumatology, College of Medicine, Kyunghee University, 1 Hoegi dong, Dongdaemun Gu, Seoul, 130 701, South Korea
    Arthritis Res Ther 8:R163. 2006
    The PD-1 (programmed death 1) molecule is a negative regulator of T cells. PDCD1 (programmed cell death 1) has been reported to have a genetic association in systemic lupus erythematosus and rheumatoid arthritis in Caucasians...
  60. pmc Interacting alleles of the coinhibitory immunoreceptor genes cytotoxic T-lymphocyte antigen 4 and programmed cell-death 1 influence risk and features of primary biliary cirrhosis
    Brian D Juran
    Center for Basic Research in Digestive Diseases, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Hepatology 47:563-70. 2008
    ..Cytotoxic T-lymphocyte antigen 4 (CTLA4) and programmed cell-death 1 (PDCD1) are two genes encoding coinhibitory immunoreceptors that harbor polymorphisms with demonstrated associations to ..
  61. pmc Differential association of programmed death-1 and CD57 with ex vivo survival of CD8+ T cells in HIV infection
    Constantinos Petrovas
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814, USA
    J Immunol 183:1120-32. 2009
    ..Thus, our data further support the role of PD-1 as a preapoptotic factor for CD8(+) T cells in HIV infection...
  62. pmc Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death
    Y Ishida
    Department of Medical Chemistry, Kyoto University Faculty of Medicine, Japan
    EMBO J 11:3887-95. 1992
    ..These results suggest that activation of the PD-1 gene may be involved in the classical type of programmed cell death...
  63. ncbi Activation-induced expression of human programmed death-1 gene in T-lymphocytes
    R Vibhakar
    Department of Pathology, New York Medical College, Elmsford 10523, USA
    Exp Cell Res 232:25-8. 1997
    ..These data suggest a role for hPD-1 during activation and differentiation of T-lymphocytes...
  64. ncbi The human PD-1 gene: complete cDNA, genomic organization, and developmentally regulated expression in B cell progenitors
    L R Finger
    Department of Medicine, New York Medical College, Elmsford 10523, USA
    Gene 197:177-87. 1997
    ..These data suggest that PD-1 may play a role in B-cell differentiation during the pro-B cell stage...
  65. ncbi PD-L2 is a second ligand for PD-1 and inhibits T cell activation
    Y Latchman
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Nat Immunol 2:261-8. 2001
    ..Taken together, these studies show overlapping functions of PD-L1 and PD-L2 and indicate a key role for the PD-L-PD-1 pathway in regulatingT cell responses...
  66. ncbi Microanatomical localization of PD-1 in human tonsils
    Yoshiko Iwai
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida, Sakyo ku, Kyoto 606 8501, Japan
    Immunol Lett 83:215-20. 2002
    ..These results suggest that PD-1 may play an important role in GC reaction...
  67. ncbi A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans
    Ludmila Prokunina
    Institute of Genetics and Pathology, Section for Medical Genetics, Rudbeck Laboratories, University of Uppsala, Dag Hammarsjölds väg 20, 751 85, Uppsala, Sweden
    Nat Genet 32:666-9. 2002
    ..We previously reported a susceptibility locus (SLEB2) for Nordic multi-case families...
  68. ncbi Program death-1 engagement upon TCR activation has distinct effects on costimulation and cytokine-driven proliferation: attenuation of ICOS, IL-4, and IL-21, but not CD28, IL-7, and IL-15 responses
    Frann Bennett
    Cambridge Antibody Technology, Abington, United Kingdom
    J Immunol 170:711-8. 2003
    ....
  69. ncbi Association of a putative regulatory polymorphism in the PD-1 gene with susceptibility to type 1 diabetes
    C Nielsen
    Department of Clinical Immunology, Odense University Hospital, Odense, Denmark
    Tissue Antigens 62:492-7. 2003
    ..92]. The associated allele is previously shown to alter a transcription factor-binding site (RUNX1/AML1), and the results of this study suggest that this allele could act as an additional susceptibility allele to type 1 diabetes...
  70. ncbi Association of a programmed death 1 gene polymorphism with the development of rheumatoid arthritis, but not systemic lupus erythematosus
    Shih Chang Lin
    Cathay General Hospital, Taipei, Taiwan
    Arthritis Rheum 50:770-5. 2004
    ..We therefore tested the potential association between PD-1 and the development of SLE and RA by conducting case-control genetic-association studies...
  71. ncbi Association of the PD-1.3A allele of the PDCD1 gene in patients with rheumatoid arthritis negative for rheumatoid factor and the shared epitope
    Ludmila Prokunina
    Uppsala University, Uppsala, Sweden
    Arthritis Rheum 50:1770-3. 2004
    To study the frequency of allele A of polymorphism PD-1.3 of the PDCD1 gene in patients with rheumatoid arthritis (RA) and its subsets, based on the presence of rheumatoid factor (RF) and the shared epitope (SE) alleles.
  72. ncbi Association of PDCD1 with susceptibility to systemic lupus erythematosus: evidence of population-specific effects
    Isabel Ferreiros-Vidal
    Hospital Clinico Universitario de Santiago de Compostela, Santiago de Compostela, Spain
    Arthritis Rheum 50:2590-7. 2004
    The A allele of the PD1.3 single-nucleotide polymorphism (SNP) on the programmed cell death gene PDCD1 was markedly more frequent in patients with systemic lupus erythematosus (SLE) than in unaffected controls in a recent study involving ..
  73. ncbi A putative regulatory polymorphism in PD-1 is associated with nephropathy in a population-based cohort of systemic lupus erythematosus patients
    C Nielsen
    Department of Clinical Immunology, Odense University Hospital, Odense, Denmark
    Lupus 13:510-6. 2004
    ..This report, for the first time, indicates that a 6867C/G SNP of the PD-1 gene is associated with lupus nephropathy in Caucasian SLE patients...
  74. ncbi A new haplotype of PDCD1 is associated with rheumatoid arthritis in Hong Kong Chinese
    Eric Kai Pang Kong
    The University of Hong Kong, Hong Kong SAR, China
    Arthritis Rheum 52:1058-62. 2005
    ..The aim of this study was to investigate the association of PDCD1 polymorphisms and haplotypes with RA in the Chinese population.
  75. ncbi PDCD1: a tissue-specific susceptibility locus for inherited inflammatory disorders
    E S James
    Nuffield Department of Clinical Medicine, The University of Oxford, John Radcliffe Hospital, Headington, Oxford, UK
    Genes Immun 6:430-7. 2005
    ..We identify 22 single-nucleotide polymorphisms (SNPs) in the equivalent human gene, PDCD1, a number of which show significant associations with the specific immunoglobulin E response to grass allergens in ..
  76. ncbi Alternative splice variants of the human PD-1 gene
    Christian Nielsen
    Department of Clinical Immunology, Odense University Hospital, Odense, Denmark
    Cell Immunol 235:109-16. 2005
    ....
  77. ncbi Enhanced expression of programmed death-1 (PD-1)/PD-L1 in salivary glands of patients with Sjögren's syndrome
    Masaya Kobayashi
    Department of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, Kobe, Japan
    J Rheumatol 32:2156-63. 2005
    ..To investigate the role of the PD-1/PD-L system in the pathology of Sjögren's syndrome (SS), we examined the expression of PD-1 and its ligand PD-L1 in salivary lymphocytes and salivary glands from patients with SS...
  78. ncbi PD-L2:PD-1 involvement in T cell proliferation, cytokine production, and integrin-mediated adhesion
    Paul A Saunders
    Bioassay Department, R and D Systems, Inc, Minneapolis, MN 55413, USA
    Eur J Immunol 35:3561-9. 2005
    ..Anti-CD3 mAb + PD-L2 stimulation also increased the level of SHP-2 associated with the PD-1 receptor. These results suggest that catalytically active SHP-2 associated with the PD-1 receptor is involved in modulating T cell function...
  79. ncbi Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction
    Lydie Trautmann
    Laboratoire d Immunologie, Centre de Recherche du Centre Hospitalier de l Université de Montréal CR CHUM Saint Luc, 264 Rene Levesque Est, Montreal, Québec H2X1P1, Canada
    Nat Med 12:1198-202. 2006
    ..The accumulation of HIV-specific dysfunctional CD8(+) T cells in the infected host could prevent the renewal of a functionally competent HIV-specific CD8(+) repertoire...
  80. ncbi PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
    Cheryl L Day
    HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu Natal, Durban 4013, South Africa
    Nature 443:350-4. 2006
    ..The inhibitory receptor programmed death 1 (PD-1; also known as PDCD1), a negative regulator of activated T cells, is markedly upregulated on the surface of exhausted virus-specific ..
  81. pmc PD-1 expression in acute hepatitis C virus (HCV) infection is associated with HCV-specific CD8 exhaustion
    Simona Urbani
    Laboratorio Immunopatologia Virale, Unit of Infectious Diseases and Hepatology, Azienda Ospedaliero Universitaria di Parma, Via Gramsci 14, 43100 Parma, Italy
    J Virol 80:11398-403. 2006
    ..Blocking PD-1/PDL-1 interaction with an anti-PDL-1 antibody improved the capacity of expansion of virus-specific CD8 cells...
  82. ncbi Programmed death-1 gene polymorphisms in patients with systemic lupus erythematosus in Taiwan
    Shu Chen Wang
    Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    J Clin Immunol 26:506-11. 2006
    ..Moreover, the association of PD-1 7209 C with susceptibility to SLE was independent of the PD-1 ligand. This study also showed that the PD-1-536 A 7146 G 7209 C 7499 G haplotype was associated with the development of SLE in Taiwan...
  83. pmc Association of PDCD1 genetic variation with risk and clinical manifestations of systemic lupus erythematosus in a multiethnic cohort
    C M Thorburn
    Department of Medicine, Rosalind Russell Medical Research Center for Arthritis, University of California San Francisco, 374 Parnassus Avenue, San Francisco, CA 94143, USA
    Genes Immun 8:279-87. 2007
    We evaluated the roles of five single-nucleotide polymorphisms (SNPs) within PDCD1, and haplotypes defined by these SNPs, for the development of systemic lupus erythematosus (SLE) and specific sub-phenotypes (nephritis, antiphospholipid ..
  84. ncbi Failure to confirm association between PDCD1 polymorphisms and rheumatoid arthritis in a Japanese population
    Takuji Iwamoto
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada, Shinjuku, Tokyo, 162 0054, Japan
    J Hum Genet 52:557-60. 2007
    Programmed cell death 1 (PDCD1) is a necessary negative regulator to maintain peripheral tolerance and is a key molecule in the development of autoimmune diseases...
  85. pmc Upregulation of PD-1 expression on circulating and intrahepatic hepatitis C virus-specific CD8+ T cells associated with reversible immune dysfunction
    Lucy Golden-Mason
    Division of Gastroenterology Hepatology, Hepatitis C Center, University of Colorado Health Sciences Center and National Jewish Hospital, Denver, CO 80262, USA
    J Virol 81:9249-58. 2007
    ..Our data indicate that the PD-1/PD-L pathway is critical in persistent HCV infection in humans and represents a potential novel target for restoring function of exhausted HCV-specific CTLs...
  86. ncbi Programmed death 1 expression on HIV-specific CD4+ T cells is driven by viral replication and associated with T cell dysfunction
    Michelle D'Souza
    Department of Medicine, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
    J Immunol 179:1979-87. 2007
    ..0078). Thus, PD-1 expression on HIV-specific CD4(+) T cells is driven by persistent HIV replication, providing a potential target for enhancing the functional capacity of HIV-specific CD4(+) T cells...
  87. ncbi Augmented expression of programmed death-1 in both neoplastic and non-neoplastic CD4+ T-cells in adult T-cell leukemia/lymphoma
    Takatoshi Shimauchi
    Department of Dermatology, University of Occupational and Environmental Health, Japan, Kitakyusyu, Fukuoka, Japan
    Int J Cancer 121:2585-90. 2007
    ....
  88. ncbi PD-1 upregulation is associated with HBV-specific T cell dysfunction in chronic hepatitis B patients
    Guoping Peng
    Key Laboratory of Health Ministry, Institute of Infectious Diseases, First Affiliated Hospital, Medical College, Zhejiang University, 79 Qingchun Road, Hangzhou, Zhejiang 310003, China
    Mol Immunol 45:963-70. 2008
    ..Thus, PD-1 upregulation on HBV-specific CD8 T cells is engaged in the dysfunction of T cells and high viraemia in CHB patients, and the antiviral T-cell responses could be improved by the blockade of this inhibitory PD-1/PD-L1 pathway...
  89. ncbi No evidence of association of the PDCD1 gene with Type 1 diabetes
    S Asad
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Diabet Med 24:1473-7. 2007
    To test the association between the immunoreceptor PD-1 (PDCD1) gene and Type 1 diabetes mellitus (T1DM)...
  90. pmc High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome
    Victoria Kasprowicz
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    J Virol 82:3154-60. 2008
    ..Our results suggest that an analysis of PD-1 expression alone is not sufficient to predict infection outcome or to determine T-cell functionality in HCV infection...
  91. doi PD-1-PD-1 ligand interaction contributes to immunosuppressive microenvironment of Hodgkin lymphoma
    Ryo Yamamoto
    Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Blood 111:3220-4. 2008
    ..Our finding provides a potentially effective immunologic strategy for the treatment of HL...
  92. doi Association of an A/C single nucleotide polymorphism in programmed cell death-ligand 1 gene with Graves' disease in Japanese patients
    Mina Hayashi
    Department of Endocrinology and Metabolism, Internal Medicine, University of the Ryukyus, Uehara 207, Nishihara, Okinawa 903 0215, Japan
    Eur J Endocrinol 158:817-22. 2008
    ..This inhibition down-regulates the immune responses. The association of a PD-L1 polymorphism with Graves' disease (GD) was studied...
  93. doi Dynamic programmed death 1 expression by virus-specific CD8 T cells correlates with the outcome of acute hepatitis B
    Zheng Zhang
    Research Center for Biological Therapy, Beijing 302 Hospital, Beijing, China
    Gastroenterology 134:1938-49, 1949.e1-3. 2008
    ....
  94. pmc Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization
    Nobuhiro Nakamoto
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Gastroenterology 134:1927-37, 1937.e1-2. 2008
    ..As hepatitis C virus (HCV) persists in the liver with immune-mediated disease pathogenesis, we examined the role of PD-1/PD-L pathway in antigen-specific CD8 T-cell dysfunction in the liver and blood of HCV-infected patients...
  95. doi PD-1, a follicular T-cell marker useful for recognizing nodular lymphocyte-predominant Hodgkin lymphoma
    Syong H Nam-Cha
    Lymphoma Group, Molecular Pathology Programme, Spanish National Cancer Centre CNIO, Madrid, Spain
    Am J Surg Pathol 32:1252-7. 2008
    ..The standard T/HRBCL cases lack follicular T-cell rosettes, whereas most of the borderline cases between the 2 entities have follicular T-cell rosettes, thus suggesting a closer relation with NLPHL...
  96. ncbi The common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 induce the expression of programmed death-1 and its ligands
    Audrey L Kinter
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 181:6738-46. 2008
    ....
  97. pmc High-programmed death-1 levels on hepatitis C virus-specific T cells during acute infection are associated with viral persistence and require preservation of cognate antigen during chronic infection
    Alleluiah Rutebemberwa
    Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    J Immunol 181:8215-25. 2008
    ..These results support the idea that PD-1 expression on T cells specific for nonescaped epitopes contributes to viral persistence and suggest that PD-1 blockade may alter the outcome of HCV infection...
  98. pmc Hepatoma cells up-regulate expression of programmed cell death-1 on T cells
    Ji Chen
    Department of Infectious Diseases, Center for Liver Diseases, Peking University First Hospital, no 8, Xishiku Street, Xicheng District, Beijing 10034, China
    World J Gastroenterol 14:6853-7. 2008
    ..To investigate the effect of hepatoma cells on up-regulation of programmed cell death-1 (PD-1), and the function of PD-1 on T cells...
  99. doi High numbers of tumor-infiltrating programmed cell death 1-positive regulatory lymphocytes are associated with improved overall survival in follicular lymphoma
    Joaquim Carreras
    Hematopathology Section, Department of Pathology, Hospital Clinic, Institut d Investigacions Biomèdiques August Pi Sunyer, University of Barcelona, Spain
    J Clin Oncol 27:1470-6. 2009
    ..The aim of this study was to determine the impact of programmed cell death 1 (PD-1) -positive inhibitory immunoregulatory lymphoid cells in the clinicobiologic features and outcome of patients with FL...
  100. pmc PDCD1 genes may protect against extraocular manifestations in Chinese Han patients with Vogt-Koyanagi-Harada syndrome
    Qianli Meng
    Zhongshan Ophthalmic Center, Sun Yat Sen University, Uveitis Study Center of Sun Yat sen University and International Uveitis Study Laboratory of Guangdong Province, State Key Laboratory of Ophthalmology of Sun Yat sen University, Guangzhou, P R China
    Mol Vis 15:386-92. 2009
    To analyze the potential association of programmed cell death 1 (PDCD1) with Vogt-Koyanagi-Harada (VKH) syndrome in a Chinese Han population.
  101. pmc PD-1 is a regulator of NY-ESO-1-specific CD8+ T cell expansion in melanoma patients
    Julien Fourcade
    Department of Medicine and Division of Hematology Oncology, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15213, USA
    J Immunol 182:5240-9. 2009
    ..They further support the use of PD-1/PD-L1 pathway blockade in cancer patients to partially restore NY-ESO-1-specific CD8(+) T cell numbers and functions, increasing the likelihood of tumor regression...

Research Grants59

  1. Esteban Celis; Fiscal Year: 2016
    ..Furthermore, exposure of tumors to IFN? enhances the expression of ligands for CD8 T cell inhibitory receptors (PD1 and LAG3), which are also detrimental for the therapeutic response to TriVax immunotherapy...
  2. LI LILY WANG; Fiscal Year: 2016
    ..It will establish a novel paradigm in which VISTA and PD- L1/PD1 synergize to control T-cell responses, thus providing a rationale for targeting VISTA either alone or in ..
  3. Lishan Su; Fiscal Year: 2016
    ..modulate human T cell function in the liver and spleen/LN in vivo? (ii) What is the role of HBV persistence and PD1/TIM3 in impaired human immune responses in the liver? (iii) Will Ad-LIGHT-HBs vaccination (with HBs clearance mAb ..
  4. George F Murphy; Fiscal Year: 2016
    ..More recently, we have shown that MMICs employ mechanisms to thwart endogenous anti-tumor immunity via the B7-2 and PD1 pathways (Cancer Res, Jan 15, 2010)...
  5. Defining the Pathogenesis of Immune Deficiency in Chronic HIV Infection
    MICHAEL MARCEL LEDERMAN; Fiscal Year: 2012
    ..Project #4: Immune activation promotes PD1 expression and immune dysfunction in chronic HIV infection - Rafick Pierre Sekaly Ph.D...
  6. Cellular Immunity and the Outcome of Hepatitis C Virus Infection
    Kyong Mi Chang; Fiscal Year: 2010
    ..in the recent literature and our preliminary data to support the relevance of immune co-stimulatory pathways (PD1, CTLA4) and immune regulatory T cells (FoxP3+ Tregs, IL10+ Tr1) in HCV-specific T cell dysfunction...
  7. LH ACTION IN OVARIAN CELL DIFFERENTIATION
    JoAnne S Richards; Fiscal Year: 2013
    ..response system, including the Toll-like receptors TLR2 and TLR4 and components of this system (C1q, Cd14, and Pdcd1) uniquely expressed in cumulus cells...
  8. COSTIMULATORY PATHWAYS IN SENSITIZED GRAFT RECIPIENTS
    Jerzy Kupiec Weglinski; Fiscal Year: 2009
    ..Aim 2: Determine the role of "negative" PD-1 (CD279) - PD-L1/-L2 T cell costimulation in alloreactive CD8 T cell memory generation, and its regulation by graft innate ..
  9. Domenico Accili; Fiscal Year: 2016
    ..cells devlop MODY, with striking abnormalities of the transcriptional networks regulated by Hnf4a, Hnf1a, and Pd1. Transcriptome analyses of the different mutants suggest a model in which FoxO control metabolic flexibility in ..
  10. Role and mechanism of negative costimulatory pathways in EAE
    Samia J Khoury; Fiscal Year: 2010
    ..Recently, other pathways that provides negative signaling to T cells has been described, the PD1-PDL1/2 pathway, and the B7-H3 and B7-H4 pathways...
  11. Gang Zhou; Fiscal Year: 2016
    ..We will also elucidate the intrinsic (PD1) and extrinsic (Treg) inhibitory mechanisms that limit the durable effectiveness of CD4 effector T cells...
  12. DANA H GABUZDA; Fiscal Year: 2014
    ..circulating microbial products due to a leaky damaged gut, in combination with specific proinflammatory cytokines, PD1/PDL-1, and other as yet unknown host factors, promote inflammation and dysfunctional immune responses in HIV-..
  13. PD-1 modulation of SIV specific CD4 and CD8 T cell responses
    FRANCOIS J VILLINGER; Fiscal Year: 2012
    ..In a second aim, blockade of the PD1-ligand interaction will be attempted during early and late chronic SIV infection in vivo to investigate whether ..
  14. GIR Antagonists: Novel Feeding/Catabolism Molecules
    SOMASUNDAR GABBITA; Fiscal Year: 2005
    ..This Phase 1 SBIR will test non-peptide small molecules, PD1-PD10, derived from T-100 structure-activity assessment of the GIR pharmacophore...
  15. Role and Mechanism of PDI-PDL Pathway in EAE
    Samia Khoury; Fiscal Year: 2007
    ..Aim 2: Role of PD 1- PDL1 in tolerance to autoantigens...
  16. Mechanisms of in vivo protection from HIV infection
    Harris Goldstein; Fiscal Year: 2010
    ..human CD34+ HSC to differentiate into functional HIV- specific CTLs, and 3) To investigate whether blockade of the PD1/PD-L1 inhibitory pathway by treatment with Fc-PD1 or lg-PD1 fusion proteins increases the in vitro and in vivo ..
  17. PHAGOCYTE RESOLVING METABOLISM
    Charles Serhan; Fiscal Year: 2009
    ..abstract_text> ..
  18. Parkinsonian mouse model: impaired respiratory enzymes
    Lars Olson; Fiscal Year: 2005
    ..Several findings indicate that respiratory chain dysfunction is directly involved in the pathogenesis of PD1.2...
  19. Protein Phosphorylation States in Drug Addiction
    Scott Edwards; Fiscal Year: 2005
    ..phosphoprotein measures will include pGluR1 and pNR1 subunits of AMPA and NMDA receptors, pDARPP-32, pCREB, and pD1 receptor using a novel site-specific antibody...
  20. Molecular Basis of Suppression of SLE by CD8+ Ti Cells
    Ram Singh; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  21. TWO NOVEL CPLA2 BINDING PROTEINS AND CELL DEATH
    JOSEPH VINCENT BONVENTRE; Fiscal Year: 2010
    ..Given the large number of patients that are initiated on dialysis each year, this addresses a critical public health problem. ..
  22. Oxidative Stress and Anti-Inflammatory Lipids in Airway Disease
    Bruce D Levy; Fiscal Year: 2010
    ..In this proposal, we seek to develop a better understanding of the natural biological processes invoked during airway infection and inflammation that dysregulate the natural homeostatic mechanisms. (End of Abstract) ..
  23. Effector Mechanisms in Graft Tolerance
    Randolph J Noelle; Fiscal Year: 2010
    ..New evidence strongly implicates IL-9 and mast cells as elements that may be important to peripheral tolerance, and studies are presented to functionally implicate their involvement. ..
  24. Tumor-induced immune suppression.
    Suzanne Ostrand Rosenberg; Fiscal Year: 2010
    ..abstract_text> ..
  25. Identification of Novel Immune Cell- the NKDC
    Drew M Pardoll; Fiscal Year: 2010
    ..Specific Aim #3: Define the capacity of NKDC to process and present antigens to T cells. Specific Aim #4: Define the role of NKDC in response to tumors. ..
  26. Lipid Mediators in the Resolution of Asthma Exacerbations
    Bruce Levy; Fiscal Year: 2008
    ..This proposal's specific aims are directed towards uncovering basic mechanisms in the pathobiology of resolution from asthma exacerbation. ..
  27. Analysis of the STAT3 Pathway In Tumor Tolerance and Immune Evasion
    Drew M Pardoll; Fiscal Year: 2010
    ....
  28. Mechanisms for SIV evasion of vaccine immunity: Role of FasL-mediated cell death
    CHARLES PAUZA; Fiscal Year: 2009
    ..By defining the role for immune cell destruction in vaccine evasion, we contribute to a complete understanding of potential mechanisms for vaccine failure that will be used to improve the design and testing of candidate HIV vaccines. ..
  29. Vaccinia Inhibition of gd T cells is a Immune Evasion Mechanism
    CHARLES PAUZA; Fiscal Year: 2008
    ..unreadable]..
  30. Analysis of Lag-3 in Regulatory T cell Function
    Drew Pardoll; Fiscal Year: 2008
    ..2) Elucidate the direct role of LAG-3 in modulating the activity of Treg cells and 3) Analyze the effect of blockade or elimination of LAG-3+ Treg cells in enhancing the activity of immunotherapies for established cancer. ..
  31. Gamma/Delta T Cells Surveillance of B Lymphoma in AIDS
    CHARLES PAUZA; Fiscal Year: 2008
    ..These approaches hold promise for better clinical management of AIDS-related B NHL,to benefit patients with HIV disease. ..
  32. RENAL CANCER ANTIGENS RECOGNIZED BY CD4 T CELLS
    Drew Pardoll; Fiscal Year: 2001
    ....
  33. ASSEMBLY/REGULATION OF CD40 RECEPTOR COMPLEX IN B CELLS
    Randolph Noelle; Fiscal Year: 2001
    ..Studies are proposed which will evaluate if engagement of one TNFR family member can prohibit the recruitment of TRAFs by other family members; and what the functional consequences of receptor desensitization are to the B-cell. ..
  34. IMPROVE PROTECTIVE RESPONSES TO ATTENUATED SHIV VACCINE
    C Pauza; Fiscal Year: 2001
    ..The investigator hypothesizes that immunizing rhesus macaques with this Lymphotactin-recombinant SHIV may shorten the time required for protective immunity by recruiting more T-cells to sites of virus replication. ..
  35. Affimetrix High Density Workstation
    Randolph Noelle; Fiscal Year: 2002
    ..abstract_text> ..
  36. HIV 1 Gene Polymorphisms Associated with Non Progression
    Thomas Greenough; Fiscal Year: 2002
    ....
  37. ANALYSIS OF E7 SPECIFIC T CELLS USING MHC-1GG MOLECULES
    Drew Pardoll; Fiscal Year: 2002
    ....
  38. NOVEL LUNG DERIVED CHALONES--BIOSYNTHESIS AND BIOACTIONS
    Bruce Levy; Fiscal Year: 2002
    ..End of Abstract) ..
  39. COGNATE ACTIVATION OF B LYMPHOCYTES
    Randolph Noelle; Fiscal Year: 2003
    ..Transitions from TI to TD-type responses will held resolve how each of these components influence B cell immunopoeisis. ..
  40. Homologous Tat Vaccine Against SHIV in Macaques
    C Pauza; Fiscal Year: 2003
    ..The Tat immunization studies also provide new information on the biology of this unusual protein, and may help to confirm its broader role in the pathogenesis of AIDS. ..
  41. Tumor cell antigen presentation to CD4 + T lymphocytes
    Suzanne Ostrand Rosenberg; Fiscal Year: 2004
    ..of anti-tumor immunity? Which effector cells, cytokines, and chemokines are induced during therapy? 5) Does tumor burden correlate with tumor-induced immuno-suppression? Does surgical removal of primary tumor reverse mmuno-suppression? ..
  42. Norepinephrine Transporter and Nociception
    Yejun Zhao; Fiscal Year: 2004
    ..The findings from these studies could potentially be translated into development of novel therapeutic targets in pain management and strategies of pain management in the cocaine abusing patient. ..
  43. CNS-RESTRICTED APC FUNCTION IN EAE
    Randolph Noelle; Fiscal Year: 2005
    ..Together, these studies will help define the role of microglial cells as APCs during the priming and effector phase in EAE. ..
  44. Gamma Delta T Cells and Innate Immunity in AIDS
    C Pauza; Fiscal Year: 2005
    ..These indirect mechanisms likely have substantial impact on disease progression, and additional work in this area will help to highlight special mechanisms that render HIV a difficult target for therapies and vaccines. ..
  45. Autoimmune Oophoritis: Consequences of Gamete Vaccines
    Kenneth Tung; Fiscal Year: 2006
    ..Specifically, we will determine the immunogenetic regulation of the immune response to CP2, and the influence of the B cell epitope specificity of the ZP Ab on the induction of progenic AOD. ..
  46. Purchase of a Xenogen's IVIS Imaging System 200 Workstation
    Randolph Noelle; Fiscal Year: 2006
    ..abstract_text> ..
  47. Mechanisms of CD40 signaling in B lympocytes in vivo
    Randolph Noelle; Fiscal Year: 2006
    ..Assuming the development of autoimmunity in Tg CD40zip mice, mutations in the TRAF binding sites of CD40zip, will be engineered to evaluate the contribution of specific TRAFs to the development of autoimmunity. ..
  48. Inducing and targeting of EBV lytic antigens in lymphoma
    Sven de Vos; Fiscal Year: 2006
    ..We anticipate a successful clinical trial and plan the extension to a larger multi center clinical trial in the time following the K23 granting period. ..
  49. Analysis of New Dendritic Cell Costimulatory Molecule
    Drew Pardoll; Fiscal Year: 2006
    ....
  50. Neurobehavioral correlates of bipolar disorder
    BRIAN O DONNELL; Fiscal Year: 2006
    ..abstract_text> ..
  51. AFP-Based Immunotherapy for Hepatocellular Carcinoma
    Antoni Ribas; Fiscal Year: 2006
    ..In summary, I propose a clinically-oriented research program that translates this original work into novel, evidence-based immnunotherapy trials for hepatocellular carcinoma. ..
  52. Regulation of Dendritic Cells and Cell Mediated Immunity by TNF family members
    Randolph Noelle; Fiscal Year: 2007
    ..We hypothesize that the combined use of TLR and CD40 agonists will be effective immunotherapeutic approaches to manage tumor models of established disease. ..
  53. Antigen Specific Immunotherapy with Transduced HSC
    Drew Pardoll; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  54. Regulation of the Immune Response to Prostate Cancer
    Charles Drake; Fiscal Year: 2007
    ..Finally, the research and training program outlined in this proposal makes full use of the collaborative and educational opportunities offered by the Johns Hopkins Oncology Center, where this work will be performed. ..
  55. BCMA: Controlling the survival of differentiated B cells
    Randolph Noelle; Fiscal Year: 2008
    ..To investigate the molecular basis of BlyS/APRIL-BCMA signaling in plasma cells and MM cell lines. To develop BCMA as a therapeutic target in MM. ..
  56. Visual Processing in Schizophrenia and SPD
    BRIAN O DONNELL; Fiscal Year: 2009
    ..These findings may identify neurobehavioral deficits common to SZ and SPD, as well as features which differentiate these disorders. ..
  57. High Resolution Ultrasound Biomicroscopy System
    Daniel Bernstein; Fiscal Year: 2005
    ....
  58. ROLE OF BETA-RECEPTOR SIGNALING IN CARDIOMYOPATHY
    Daniel Bernstein; Fiscal Year: 2010
    ..However, our data suggest that the intricacies of b-AR subtype signaling, the temporal dependence of this signaling, and the multiple pathways of potential crosstalk, are quite a bit more complex. ..