PCAF

Summary

Gene Symbol: PCAF
Description: lysine acetyltransferase 2B
Alias: CAF, P/CAF, PCAF, histone acetyltransferase KAT2B, CREBBP-associated factor, K(lysine) acetyltransferase 2B, histone acetylase PCAF, histone acetyltransferase PCAF, p300/CBP-associated factor
Species: human

Top Publications

  1. ncbi Interactions between dietary calcium and caffeine consumption on calcium metabolism in hypertensive humans
    K J Wise
    Department of Food Science and Human Nutrition, Washington State University, Spokane 99204-0399, USA
    Am J Hypertens 9:223-9. 1996
  2. ncbi Differential roles of p300 and PCAF acetyltransferases in muscle differentiation
    P L Puri
    Laboratory of Gene Expression, Fondazione Andrea Cesalpino, Istituto I Clinica Medica, Policlinico Umberto I, University of Rome, La Sapienza, Italy
    Mol Cell 1:35-45. 1997
  3. ncbi Tat acetyl-acceptor lysines are important for human immunodeficiency virus type-1 replication
    Vanessa Brès
    Institut de Genetique Humaine, CNRS UPR 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    J Biol Chem 277:22215-21. 2002
  4. pmc CAF-mediated human immunodeficiency virus (HIV) type 1 transcriptional inhibition is distinct from alpha-defensin-1 HIV inhibition
    Theresa Li Yun Chang
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Virol 77:6777-84. 2003
  5. ncbi Regulation of transforming growth factor-beta and bone morphogenetic protein signalling by transcriptional coactivator GCN5
    Kaoru Kahata
    Department of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 170 8455, Japan
    Genes Cells 9:143-51. 2004
  6. ncbi Tip60 and histone deacetylase 1 regulate androgen receptor activity through changes to the acetylation status of the receptor
    Luke Gaughan
    Prostate Research Group, School of Surgical Sciences, University of Newcastle upon Tyne, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom
    J Biol Chem 277:25904-13. 2002
  7. ncbi The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention
    Miguel Stevens
    Rega Institute for Medical Research, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    Med Res Rev 26:595-625. 2006
  8. pmc An interaction between the human T cell leukemia virus type 1 basic leucine zipper factor (HBZ) and the KIX domain of p300/CBP contributes to the down-regulation of tax-dependent viral transcription by HBZ
    Isabelle Clerc
    Université Montpellier 1 and CNRS, UM5236, Centre d Etudes d Agents Pathogenes et Biotechnologies pour la Sante CPBS, Montpellier, France
    J Biol Chem 283:23903-13. 2008
  9. ncbi p300 and p300/cAMP-responsive element-binding protein associated factor interact with human T-cell lymphotropic virus type-1 Tax in a multi-histone acetyltransferase/activator-enhancer complex
    R Harrod
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    J Biol Chem 275:11852-7. 2000
  10. pmc p73 Interacts with human immunodeficiency virus type 1 Tat in astrocytic cells and prevents its acetylation on lysine 28
    Shohreh Amini
    Center for Neurovirology and Cancer Biology, Temple University, 1900 North 12th Street, Philadelphia, PA 19122, USA
    Mol Cell Biol 25:8126-38. 2005

Research Grants

  1. WAYNE WILLIAM HANCOCK; Fiscal Year: 2015
  2. Histone Acetylation and Insulin Gene Expression
    Sabire Ozcan; Fiscal Year: 2010
  3. Ronen Marmorstein; Fiscal Year: 2016
  4. Shelley L Berger; Fiscal Year: 2016
  5. Role of IKK in NSCLC: Modulation of SMRT and NF-kappaB
    Marty W Mayo; Fiscal Year: 2012
  6. ABUSE LIABILITY OF DRUG ADJUNCTS FOR COCAINE WITHDRAWL
    Frank Holloway; Fiscal Year: 1992
  7. Nicola C Partridge; Fiscal Year: 2016
  8. Regulation of CFTR gene expression
    Martin Walsh; Fiscal Year: 2004
  9. Maria Trojanowska; Fiscal Year: 2016
  10. Effect of chromatin remodelers/modifiers on HIV-1 Tat activated transcription
    Fatah Kashanchi; Fiscal Year: 2010

Detail Information

Publications246 found, 100 shown here

  1. ncbi Interactions between dietary calcium and caffeine consumption on calcium metabolism in hypertensive humans
    K J Wise
    Department of Food Science and Human Nutrition, Washington State University, Spokane 99204-0399, USA
    Am J Hypertens 9:223-9. 1996
    ..who habitually consumed at least 175 mg caffeine daily were studied before and after abstinence from all caffeine (CAF) consumption for 2 weeks...
  2. ncbi Differential roles of p300 and PCAF acetyltransferases in muscle differentiation
    P L Puri
    Laboratory of Gene Expression, Fondazione Andrea Cesalpino, Istituto I Clinica Medica, Policlinico Umberto I, University of Rome, La Sapienza, Italy
    Mol Cell 1:35-45. 1997
    b>PCAF is a histone acetyltransferase that associates with p300/CBP and competes with E1A for access to them...
  3. ncbi Tat acetyl-acceptor lysines are important for human immunodeficiency virus type-1 replication
    Vanessa Brès
    Institut de Genetique Humaine, CNRS UPR 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    J Biol Chem 277:22215-21. 2002
    ..Our results highlight the importance of lysine 28 and lysine 50 of Tat in virus replication and Tat-mediated trans-activation...
  4. pmc CAF-mediated human immunodeficiency virus (HIV) type 1 transcriptional inhibition is distinct from alpha-defensin-1 HIV inhibition
    Theresa Li Yun Chang
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Virol 77:6777-84. 2003
    ..virus type 1 (HIV-1) replication by secreting a soluble factor(s) known as CD8(+) T-lymphocyte antiviral factor (CAF)...
  5. ncbi Regulation of transforming growth factor-beta and bone morphogenetic protein signalling by transcriptional coactivator GCN5
    Kaoru Kahata
    Department of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 170 8455, Japan
    Genes Cells 9:143-51. 2004
    ..GCN5 is structurally similar to PCAF, which was previously identified as a coactivator for receptor-regulated Smads (R-Smads) for TGF-beta signalling ..
  6. ncbi Tip60 and histone deacetylase 1 regulate androgen receptor activity through changes to the acetylation status of the receptor
    Luke Gaughan
    Prostate Research Group, School of Surgical Sciences, University of Newcastle upon Tyne, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom
    J Biol Chem 277:25904-13. 2002
    ....
  7. ncbi The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention
    Miguel Stevens
    Rega Institute for Medical Research, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    Med Res Rev 26:595-625. 2006
    ..As such, targeting of Tat protein (and/or cellular cofactors) provide an interesting perspective for therapeutic intervention in the HIV replicative cycle and may afford lifetime control of the HIV infection...
  8. pmc An interaction between the human T cell leukemia virus type 1 basic leucine zipper factor (HBZ) and the KIX domain of p300/CBP contributes to the down-regulation of tax-dependent viral transcription by HBZ
    Isabelle Clerc
    Université Montpellier 1 and CNRS, UM5236, Centre d Etudes d Agents Pathogenes et Biotechnologies pour la Sante CPBS, Montpellier, France
    J Biol Chem 283:23903-13. 2008
    ..Our findings demonstrate that HBZ utilizes a bipartite mechanism to repress viral transcription...
  9. ncbi p300 and p300/cAMP-responsive element-binding protein associated factor interact with human T-cell lymphotropic virus type-1 Tax in a multi-histone acetyltransferase/activator-enhancer complex
    R Harrod
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    J Biol Chem 275:11852-7. 2000
    ..Here, we report that the p300/CBP-associated factor (P/CAF) is a critical and integral component of the functional HTLV-1 activator-enhancer complex...
  10. pmc p73 Interacts with human immunodeficiency virus type 1 Tat in astrocytic cells and prevents its acetylation on lysine 28
    Shohreh Amini
    Center for Neurovirology and Cancer Biology, Temple University, 1900 North 12th Street, Philadelphia, PA 19122, USA
    Mol Cell Biol 25:8126-38. 2005
    ..Association of p73 with Tat prevented the acetylation of Tat on lysine 28 by PCAF. Functional studies including RNA interference showed that p73 inhibited Tat stimulation of the HIV-1 promoter...
  11. pmc Synergistic activation of human involucrin gene expression by Fra-1 and p300--evidence for the presence of a multiprotein complex
    James F Crish
    Department of Physiology and Biophysics, Case School of Medicine, Cleveland, Ohio, USA
    J Invest Dermatol 128:530-41. 2008
    ..Fra-1 also interacts with other proteins that interact at the AP1-5 site, including JunD, JunB, Sp1, and P/CAF. Contrary to results in some other systems, Fra-1 functions as a positive transcriptional regulator in human ..
  12. ncbi Steroid receptor coactivator-1 is a histone acetyltransferase
    T E Spencer
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 389:194-8. 1997
    ..histone acetyltransferase activity and that it also interacts with another HAT, p300/CBP-associated factor (PCAF). The HAT activity of SRC-1 maps to its carboxy-terminal region and is primarily specific for histones H3 and H4...
  13. ncbi M phase-specific phosphorylation of BRCA2 by Polo-like kinase 1 correlates with the dissociation of the BRCA2-P/CAF complex
    Horng Ru Lin
    Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center, San Antonio, Texas 78245, USA
    J Biol Chem 278:35979-87. 2003
    ..modifying activity through interaction with a histone acetyltransferase protein, p300/CBP-associated factor (P/CAF)...
  14. pmc Extracellular signals regulate rapid coactivator recruitment at AP-1 sites by altered phosphorylation of both CREB binding protein and c-jun
    Linh N Tsai
    University of Illinois Cancer Center, 801 S Paulina Street, Room 530C, MC860, Chicago, IL 60612, USA
    Mol Cell Biol 28:4240-50. 2008
    ..CREB binding protein (CBP) and p300/CBP-associated factor (PCAF) were displaced from transcription factor binding sites on the MMP-9 promoter within minutes of RA treatment...
  15. ncbi TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1
    A Takeshita
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 272:27629-34. 1997
    ..These results suggest that TRAM-1 is a coactivator that may exhibit its activity by interacting with subdomains of NRs other than the AF-2 region, in contrast to SRC-1/TIF2...
  16. ncbi Activation of integrated provirus requires histone acetyltransferase. p300 and P/CAF are coactivators for HIV-1 Tat
    M Benkirane
    Molecular Virology Section, Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 273:24898-905. 1998
    ..Intracellularly, we found that Tat forms a ternary complex with p300 and P/CAF, two histone acetyltransferases (HATs)...
  17. ncbi Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator
    A Marcello
    Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
    IUBMB Life 51:175-81. 2001
    ..Besides histones, Tat itself is a substrate for the enzymatic activity of p300/CBP and of the associated factor P/CAF, suggesting a regulatory role of acetylation on the protein itself...
  18. ncbi The activation function-1 domain of Nur77/NR4A1 mediates trans-activation, cell specificity, and coactivator recruitment
    K D Senali Abayratna Wansa
    University of Queensland Centre for Molecular and Cellular Biology Institute for Molecular Bioscience, St Lucia, Queensland 4072, Australia
    J Biol Chem 277:33001-11. 2002
    ..the N-terminal AB region (not the LBD) facilitates coactivator recruitment and directly interacts with SRC, p300, PCAF, and DRIP-205...
  19. ncbi Human immunodeficiency virus type-1 Tat/co-activator acetyltransferase interactions inhibit p53Lys-320 acetylation and p53-responsive transcription
    Robert Harrod
    Laboratory of Molecular Virology, Department of Biological Sciences, Southern Methodist University, Dallas, Texas 75275 0376, USA
    J Biol Chem 278:12310-8. 2003
    ..Our results allude to a mechanism whereby the human immunodeficiency virus type-1 trans-activator might impair tumor suppressor functions in immune/neuronal-derived cells, thus favoring the establishment of neoplasia during AIDS...
  20. ncbi HIV-1 infection and regulation of Tat function in macrophages
    Li Ying Liou
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Int J Biochem Cell Biol 36:1767-75. 2004
    ..Future studies of cyclin T1 regulation in macrophages may suggest means of manipulating expression of this crucial cellular co-factor for therapeutic benefit in HIV-1 infected individuals...
  21. ncbi HIV-1 Tat interactions with p300 and PCAF transcriptional coactivators inhibit histone acetylation and neurotrophin signaling through CREB
    Kasuen Wong
    Laboratory of Molecular Virology, Department of Biological Sciences, Southern Methodist University, Dallas, Texas 75275 0376, USA
    J Biol Chem 280:9390-9. 2005
    ..coactivators/acetyltransferases, p300/CREB-binding protein, and p300/CREB-binding protein-associated factor (PCAF); and induces neuronal apoptosis...
  22. ncbi A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A
    X J Yang
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 2753, USA
    Nature 382:319-24. 1996
    ..A new cellular p300/CBP-associated factor (P/CAF) having intrinsic histone acetylase activity has been identified that competes with E1A...
  23. ncbi The transcriptional coactivators p300 and CBP are histone acetyltransferases
    V V Ogryzko
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 2753, USA
    Cell 87:953-9. 1996
    ..One such factor, the cellular p300/CBP associated factor (PCAF), possesses intrinsic histone acetyltransferase activity...
  24. ncbi Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300
    H Chen
    Howard Hughes Medical Institute, School of Medicine, University of California at San Diego, La Jolla 92037, USA
    Cell 90:569-80. 1997
    ..ACTR also recruits two other nuclear factors, CBP and P/CAF, and thus plays a central role in creating a multisubunit coactivator complex...
  25. ncbi Transcription factor-specific requirements for coactivators and their acetyltransferase functions
    E Korzus
    Howard Hughes Medical Institute, University of California San Diego UCSD, 9500 Gilman Drive, La Jolla, CA 92093 0648, USA
    Science 279:703-7. 1998
    ..including CREB-binding protein (CBP/p300), nuclear receptor coactivators (NCoAs), and p300/CBP-associated factor (p/CAF), based on their platform or assembly properties...
  26. ncbi Histone-like TAFs within the PCAF histone acetylase complex
    V V Ogryzko
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cell 94:35-44. 1998
    b>PCAF histone acetylase plays a role in regulation of transcription, cell cycle progression, and differentiation. Here, we show that PCAF is found in a complex consisting of more than 20 distinct polypeptides...
  27. pmc DNA damage activates p53 through a phosphorylation-acetylation cascade
    K Sakaguchi
    Laboratory of Cell Biology, National Cancer Institute NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genes Dev 12:2831-41. 1998
    ..acetylated in vitro at separate sites by two different histone acetyltransferases (HATs), the coactivators p300 and PCAF. p300 acetylates Lys-382 in the carboxy-terminal region of p53, whereas PCAF acetylates Lys-320 in the nuclear ..
  28. pmc p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage
    L Liu
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 19:1202-9. 1999
    ..suggest that full transcriptional activity of p53 requires the coactivators CREB binding protein (CBP)/p300 and PCAF. These coactivators interact with each other, and both possess intrinsic histone acetyltransferase activity...
  29. pmc HIV-1 tat transcriptional activity is regulated by acetylation
    R E Kiernan
    Laboratoire de Virologie Moléculaire et Transfert de Gène, Institut de Genetique Humaine, UPR1142 Montpellier, 34396, France
    EMBO J 18:6106-18. 1999
    ..trans-activator protein (Tat)-associated histone acetyltransferases (TAHs), p300 and p300/CBP-associating factor (PCAF), assist functionally in the activation of chromosomally integrated HIV-1 LTR...
  30. ncbi Acetylation of MyoD directed by PCAF is necessary for the execution of the muscle program
    V Sartorelli
    Institute for Genetic Medicine, University of Southern California, Los Angeles 90033, USA
    Mol Cell 4:725-34. 1999
    p300/CBP and PCAF coactivators have acetyltransferase activities and regulate transcription, cell cycle progression, and differentiation. They are both required for MyoD activity and muscle differentiation...
  31. ncbi p300 and p300/cAMP-response element-binding protein-associated factor acetylate the androgen receptor at sites governing hormone-dependent transactivation
    M Fu
    Albert Einstein Cancer Center, Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 275:20853-60. 2000
    ..The identification of the AR as a direct target of histone acetyltransferase co-activators has important implications for targeting inhibitors of AR function...
  32. pmc Modulation of histone acetyltransferase activity through interaction of epstein-barr nuclear antigen 3C with prothymosin alpha
    M A Cotter
    Department of Microbiology and Immunology and Cellular and Molecular Biology Program, University of Michigan Medical School, University of Michigan Medical Center, University of Michigan, Ann Arbor, Michigan 48109, USA
    Mol Cell Biol 20:5722-35. 2000
    ....
  33. pmc The transcriptional co-activator P/CAF potentiates TGF-beta/Smad signaling
    S Itoh
    The Netherlands Cancer Institute, Division of Cellular Biochemistry, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Nucleic Acids Res 28:4291-8. 2000
    ..Here we investigated the possible co-activator function of P/CAF in TGF-beta/Smad signaling. P/CAF was found to interact directly with Smad3 in vitro...
  34. pmc Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2
    Chao Zhong Song
    Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195, USA
    J Biol Chem 277:7029-36. 2002
    ..Our results show that both CBP/p300 and p300/CBP-associated factor (PCAF) enhance FKLF2 transcriptional activity...
  35. ncbi Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain
    Shiraz Mujtaba
    Structural Biology Program, Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York University, New York, NY 10029, USA
    Mol Cell 9:575-86. 2002
    ..association with nuclear histone acetyltransferases p300/CBP (CREB binding protein) and p300/CBP-associated factor (PCAF)...
  36. ncbi MDM2 inhibits PCAF (p300/CREB-binding protein-associated factor)-mediated p53 acetylation
    Yetao Jin
    Department of Biochemistry and Molecular Biology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97201, USA
    J Biol Chem 277:30838-43. 2002
    ..Because PCAF (p300/CREB-binding protein-associated factor) also acetylates and activates p53 after DNA damage, in this study we ..
  37. ncbi Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state
    Marcella Fulco
    Muscle Gene Expression Group, Laboratory of Muscle Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Cell 12:51-62. 2003
    ..Sir2 forms a complex with the acetyltransferase PCAF and MyoD and, when overexpressed, retards muscle differentiation...
  38. pmc Mechanisms of P/CAF auto-acetylation
    Helena Santos-Rosa
    Instituto de Biologia Molecular de Barcelona, CID, Consejo Superior de Investigaciones Cientificas CSIC, Jordi Girona 18 26, E 08034 Barcelona, Spain
    Nucleic Acids Res 31:4285-92. 2003
    P/CAF is a histone acetyltransferase enzyme which was originally identified as a CBP/p300-binding protein. In this manuscript we report that human P/CAF is acetylated in vivo...
  39. ncbi Molecular basis for Gcn5/PCAF histone acetyltransferase selectivity for histone and nonhistone substrates
    Arienne N Poux
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Biochemistry 42:14366-74. 2003
    ..protein (tGcn5) bound to its preferred histone H3 substrate, revealing the mode of substrate binding by the Gcn5/PCAF family of HAT proteins...
  40. ncbi MDM2 mediates p300/CREB-binding protein-associated factor ubiquitination and degradation
    Yetao Jin
    Department of Biochemistry and Molecular Biology, Oregon Health and Science University, 3181 Sam Jackson Park Road, Portland, OR 97239, USA
    J Biol Chem 279:20035-43. 2004
    ..a negative feedback regulator of the tumor suppressor p53, inhibits p300/CREB-binding protein-associated factor (PCAF)-mediated p53 acetylation. Our further study showed that MDM2 also regulates the stability of PCAF...
  41. pmc The c-MYC oncoprotein is a substrate of the acetyltransferases hGCN5/PCAF and TIP60
    Jagruti H Patel
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Mol Cell Biol 24:10826-34. 2004
    ..in part on the recruitment of cofactor complexes containing the histone acetyltransferases mammalian GCN5 (mGCN5)/PCAF and TIP60...
  42. ncbi Trichostatin A induces transforming growth factor beta type II receptor promoter activity and acetylation of Sp1 by recruitment of PCAF/p300 to a Sp1.NF-Y complex
    Weiqi Huang
    Department of Medicine, Division of Medical Oncology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, Texas 78229 3900, USA
    J Biol Chem 280:10047-54. 2005
    ..of cells with TSA activates the TbetaRII promoter in a time-dependent manner through the recruitment of p300 and PCAF into a Sp1.NF-Y.HDAC complex that binds this DNA element...
  43. pmc Acetylation of HIV-1 integrase by p300 regulates viral integration
    Anna Cereseto
    Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology ICGEB, Trieste, Italy
    EMBO J 24:3070-81. 2005
    ..This is the first demonstration that HIV-1 IN activity is specifically regulated by post-translational modification...
  44. ncbi Phosphorylation of SATB1, a global gene regulator, acts as a molecular switch regulating its transcriptional activity in vivo
    P Pavan Kumar
    National Centre for Cell Science, Ganeshkhind, Pune 411007, India
    Mol Cell 22:231-43. 2006
    ..We show here that phosphorylation by PKC acts as a switch to determine whether SATB1 interacts with HDAC1 or PCAF. Phosphorylation and dephosphorylation of SATB1 exerted opposing effects on MAR-linked reporter activity in vivo...
  45. pmc Acetylation of conserved lysines in the catalytic core of cyclin-dependent kinase 9 inhibits kinase activity and regulates transcription
    Arianna Sabò
    ICGEB Trieste, Molecular Medicine Laboratory, Padriciano, 99, 34012 Trieste, Italy
    Mol Cell Biol 28:2201-12. 2008
    ..Here we show that cellular GCN5 and P/CAF, members of the GCN5-related N-acetyltransferase family of histone acetyltransferases, regulate CDK9 function by ..
  46. pmc PCAF is an HIF-1alpha cofactor that regulates p53 transcriptional activity in hypoxia
    G Xenaki
    School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, UK
    Oncogene 27:5785-96. 2008
    ..conditions p53 acetylation is reduced to a greater extent at K320 site targeted by P300/CBP-associated factor (PCAF) than at K382 site targeted by p300/CBP...
  47. pmc The histone acetyltransferase PCAF associates with actin and hnRNP U for RNA polymerase II transcription
    Ales Obrdlik
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, Stockholm, Sweden
    Mol Cell Biol 28:6342-57. 2008
    ..interaction assays, and biochemical fractionation of nuclear extracts that the histone acetyltransferase (HAT) PCAF associates with actin and hnRNP U...
  48. doi Autoacetylation regulates P/CAF nuclear localization
    Noemí Blanco-García
    Instituto de Biologia Molecular de Barcelona, Consejo Superior de Investigaciones Cientificas, Baldiri i Reixac 15 21, Parc Cientific de Barcelona, E 08028 Barcelona, Spain
    J Biol Chem 284:1343-52. 2009
    ..The acetyltransferase P/CAF is autoacetylated and acetylated by p300 in vivo...
  49. pmc hSirT1-dependent regulation of the PCAF-E2F1-p73 apoptotic pathway in response to DNA damage
    Natalia Pediconi
    Laboratory of Gene Expression, Fondazione A Cesalpino, Viale del Policlinico 155, 00161 Rome, Italy
    Mol Cell Biol 29:1989-98. 2009
    ..Here we show that the hSirT1/PCAF interaction controls the E2F1/p73 apoptotic pathway...
  50. pmc Degradation of cyclin A is regulated by acetylation
    F Mateo
    Faculty of Medicine, Department of Cell Biology and Pathology, University of Barcelona, Barcelona, Spain
    Oncogene 28:2654-66. 2009
    ..Here, we report that the acetyltransferase P/CAF directly interacts with cyclin A that as a consequence becomes acetylated at lysines 54, 68, 95 and 112...
  51. pmc The transcriptional co-activator PCAF regulates cdk2 activity
    Francesca Mateo
    Department of Cell Biology, Immunology and Neurosciences, Faculty of Medicine, University of Barcelona, Spain
    Nucleic Acids Res 37:7072-84. 2009
    ..We report here that the transcriptional co-activator PCAF directly interacts with cdk2. This interaction is mainly produced during S and G(2)/M phases of the cell cycle...
  52. pmc Restoration of DNA-binding and growth-suppressive activity of mutant forms of p53 via a PCAF-mediated acetylation pathway
    Ricardo E Perez
    Department of Oncology, School of Medicine, Georgetown University, Lombardi Comprehensive Cancer Center, Washington, District of Columbia 20057, USA
    J Cell Physiol 225:394-405. 2010
    ..Here, we show that the PCAF acetyl-transferase is down-regulated in tumors harboring p53 mutants, where its re-expression leads to p53 ..
  53. doi Genetic variation in PCAF, a key mediator in epigenetics, is associated with reduced vascular morbidity and mortality: evidence for a new concept from three independent prospective studies
    Douwe Pons
    Department of Cardiology, Leiden University Medical Center, RC Leiden, The Netherlands
    Heart 97:143-50. 2011
    ..study was designed to investigate the counterbalancing influence of genetic variation in the promoter of the gene encoding P300/CBP associated factor (PCAF), a lysine acetyltransferase (KAT), on coronary heart disease (CHD) and mortality.
  54. pmc The histone acetyltransferase PCAF regulates p21 transcription through stress-induced acetylation of histone H3
    Ian M Love
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, USA
    Cell Cycle 11:2458-66. 2012
    ..Several histone acetyl transferases (HATs), including p300, CBP, PCAF and GCN5 have been implicated in the activation of p53-dependent transcription of the cyclin-dependent kinase (cdk) ..
  55. ncbi [Expression of PCAF in hepatocellular carcinoma and its clinical significance]
    Hang Tuo
    Department of Hepatobiliary Surgery, Xi an Jiaotong University, Xi an, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 29:297-300. 2013
    To investigate the expression of P300/CBP-associated factor (PCAF) in hepatocellular carcinoma (HCC) and its clinical significance.
  56. pmc Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription
    V Muth
    Division of Molecular Biology of the Cell II, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    EMBO J 20:1353-62. 2001
    ..of the promoter-proximal terminator, we found that TTF-I associates with the p300/CBP-associated factor PCAF, suggesting that TTF-I may target histone acetyltransferase to the rDNA promoter...
  57. ncbi Overlapping but distinct patterns of histone acetylation by the human coactivators p300 and PCAF within nucleosomal substrates
    R L Schiltz
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 274:1189-92. 1999
    ..We have determined the core histone residues acetylated in vitro by recombinant p300 and PCAF within mononucleosomes...
  58. ncbi Specific role for p300/CREB-binding protein-associated factor activity in E2F1 stabilization in response to DNA damage
    Alessandra Ianari
    Department of Experimental Medicine and Pathology, University of Rome La Sapienza, 00161 Rome, Italy
    J Biol Chem 279:30830-5. 2004
    ..Finally, we report that the formation of E2F1-p300/CREB-binding protein-associated factor (P/CAF) complexes is preferentially induced in doxorubicin-treated cells, and that P/CAF acetyltransferase (HAT), but not ..
  59. ncbi Intrinsic ubiquitination activity of PCAF controls the stability of the oncoprotein Hdm2
    Laetitia K Linares
    Centre de Recherches de Biochimie Macromoleculaire, CNRS UMII UMR5237, Montpellier, France
    Nat Cell Biol 9:331-8. 2007
    The p300-CBP-associated factor (PCAF) is a histone acetyltransferase (HAT) involved in the reversible acetylation of various transcriptional regulators, including the tumour suppressor p53...
  60. ncbi Transcriptional activation by hepatocyte nuclear factor-1 requires synergism between multiple coactivator proteins
    E Soutoglou
    Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, 711 10 Herakleion Crete, Greece
    J Biol Chem 275:12515-20. 2000
    ..interact with the histone acetyltransferases (HATs) CREB-binding protein (CBP), p300/CBP-associated factor (P/CAF), Src-1, and RAC3...
  61. ncbi In vitro acetylation of HMGB-1 and -2 proteins by CBP: the role of the acidic tail
    Evdokia Pasheva
    Institute of Molecular Biology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
    Biochemistry 43:2935-40. 2004
    Histone acetyltransferases CBP, PCAF, and Tip60 have been tested for their ability to in vitro acetylate HMGB-1 and -2 proteins and their truncated forms lacking the C-terminal tail...
  62. ncbi The multiple functions of HIV-1 Tat: proliferation versus apoptosis
    Francesca Peruzzi
    Center for Neurovirology and Cancer Biology, Temple University, Philadelphia, Pennsylvania 19122, USA
    Front Biosci 11:708-17. 2006
    ..Here, we discuss intracellular activities of Tat in HIV-infected cells, as well as in cells exposed to Tat, and focus on two contradictory aspects of Tat-mediated effects: cell proliferation and cell death...
  63. ncbi Haploinsufficient prostate tumor suppression by Nkx3.1: a role for chromatin accessibility in dosage-sensitive gene regulation
    Ashish P Mogal
    Department of Pathology, Vanderbilt University Medical Center, Nashville 37232, USA
    J Biol Chem 282:25790-800. 2007
    ..Our results reveal how the interplay between transcription factor dosage and chromatin affects target gene expression in tumor initiation...
  64. pmc Ecteinascidin 743, a transcription-targeted chemotherapeutic that inhibits MDR1 activation
    S Jin
    Molecular Pharmacology and Therapeutics Program, Memorial Sloan-Kettering Cancer Center and the Weill Graduate School of Medical Sciences of Cornell University, 1275 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 97:6775-9. 2000
    ..human P glycoprotein gene (MDR1) by a variety of inducers and that NF-Y functions by recruiting the histone acetyltransferase PCAF to the MDR1 promoter...
  65. pmc Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12
    K Ito
    Thoracic Medicine, Imperial College School of Medicine at the National Heart and Lung Institute, London, United Kingdom
    Mol Cell Biol 20:6891-903. 2000
    ..This further suggests that pharmacological manipulation of of specific histone acetylation status is a potentially useful approach for the treatment of inflammatory diseases...
  66. ncbi In vivo complex formation of PU.1 with HDAC1 associated with PU.1-mediated transcriptional repression
    F Kihara-Negishi
    Department of Cell Genetics, Sasaki Institute, 2 2, Kanda Surugadai, Chiyoda ku, Tokyo 101 0062, Japan
    Oncogene 20:6039-47. 2001
    ..It was unlikely that the repression was due to sequestration of a limited amount of CBP/p300 nor pCAF, because overexpression of these co-activators did not relieve PU.1-mediated transcriptional repression...
  67. ncbi Protein coregulators that mediate estrogen receptor function
    T Ratajczak
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA, Australia
    Reprod Fertil Dev 13:221-9. 2001
    ..selected members of the multifunctional steroid receptor coactivator family and the cointegrators, p300/CBP and P/CAF. The intrinsic histone acetylase activity mediated by these coactivator and cointegrator proteins, alters chromatin ..
  68. ncbi Temporal formation of distinct thyroid hormone receptor coactivator complexes in HeLa cells
    D Sharma
    Department of Physiology, University of Maryland School of Medicine, Baltimore 21201, USA
    Mol Endocrinol 14:2001-9. 2000
    ..line, we show that interaction of TR with members of the p160/SRC family, CBP, and the p300/CBP-associated factor (PCAF) occurs rapidly (approximately 10 min) following addition of thyroid hormone (T3)...
  69. ncbi Inhibitors of arachidonic acid metabolism have variable effects on calcium signaling pathways
    H Kanda
    Department of Veteran's Affairs Greater Los Angeles Healthcare System, Sepulveda, California 91343, USA
    Am J Hypertens 14:248-53. 2001
    ..7 +/- 4.8 nmol/L, n = 9, IBU; 40.3 +/- 8.8 nmol/L, n = 8, P < .05 v control). Both caffeine (CAF) and ryanodine (RY) treatment attenuated Ang II-induced [Ca2+]i; however, pretreatment with ETI, IBU, or 7ER did ..
  70. pmc A quantitative study on the in vitro and in vivo acetylation of high mobility group A1 proteins
    Qingchun Zhang
    Department of Chemistry 027, University of California, Riverside, California 92521 0403, USA
    J Am Soc Mass Spectrom 18:1569-78. 2007
    ..mass spectrometry, the acetylation of HMGA1a and HMGA1b proteins induced by histone acetyltransferases p300 and PCAF in vitro and in PC-3 human prostate cancer cells in vivo. It turned out that five lysine residues in HMGA1a, i.e...
  71. doi HDAC inhibition promotes neuronal outgrowth and counteracts growth cone collapse through CBP/p300 and P/CAF-dependent p53 acetylation
    P Gaub
    Center for Neurology, Hertie Institute for Clinical Brain Research, University of Tuebingen, Germany
    Cell Death Differ 17:1392-408. 2010
    ..Next, we specifically show that the expression of the histone acetyltransferases CBP/p300 and P/CAF is repressed in neurons by inhibitory substrates, whereas it is triggered by HDAC inhibition on both permissive and ..
  72. ncbi A randomized trial of chemotherapy with or without estrogenic recruitment in locally advanced breast cancer. North-West Oncology Group (GONO) Study, Italy
    E Baldini
    U.O. Oncologia Medica, Pisa, Italy
    Tumori 83:829-33. 1997
    ..v.), doxorubicin (50 mg/m2 i.v.) and fluorouracil (600 mg/m2 i.v.) (CAF) on day 1, or DES-CAF (DES, 1 mg orally days 1-3, CAF on day 4). The courses were repeated every 3 weeks...
  73. ncbi Expression of PCAF, p300 and Gcn5 and more highly acetylated histone H4 in pediatric tumors
    C Armas-Pineda
    Departamento de Oncologia, Hospital Infantil de México Federico Gómez S S, Mexico
    J Exp Clin Cancer Res 26:269-76. 2007
    ..In this paper, the expression of the PCAF, p300 and Gcn5 HATs by RT-PCR in 34 tumor samples was evaluated...
  74. ncbi The histone acetyltransferase activity of human GCN5 and PCAF is stabilized by coenzymes
    J E Herrera
    Laboratory of Molecular Carcinogenesis, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 272:27253-8. 1997
    Here we report that PCAF and human GCN5, two related type A histone acetyltransferases, are unstable enzymes that under the commonly used assay conditions are rapidly and irreversibly inactivated...
  75. ncbi NF-Y is associated with the histone acetyltransferases GCN5 and P/CAF
    R A Currie
    Laboratory of Gene Regulation, Picower Institute for Medical Research, Manhasset, New York 11030, USA
    J Biol Chem 273:1430-4. 1998
    ..activity through physical association with the related histone acetyltransferase enzymes, human GCN5 and P/CAF in vivo...
  76. doi Mice knock out for the histone acetyltransferase p300/CREB binding protein-associated factor develop a resistance to amyloid toxicity
    F Duclot
    INSERM U 710, Montpellier, France
    Neuroscience 167:850-63. 2010
    p300/CREB binding protein-associated factor (PCAF) regulates gene expression by acting through histone acetylation and as a transcription coactivator...
  77. ncbi Distant recurrence in breast cancer. Survival expectations and first choice of chemotherapy regimen
    H Brincker
    Department of Oncology and Radiotherapy, Odense University Hospital, Denmark
    Acta Oncol 27:729-32. 1988
    ..The DBCG trial 80-R2 is the largest randomized trial of CAF (cyclophosphamide, doxorubicin, 5-fluorouracil) versus CMF (cyclophosphamide, methotrexate, 5-fluorouracil) in ..
  78. pmc HDAC4 and PCAF bind to cardiac sarcomeres and play a role in regulating myofilament contractile activity
    Mahesh P Gupta
    Department of Surgery, Committee on Molecular Medicine, Biological Science Division, University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    J Biol Chem 283:10135-46. 2008
    ..We found that a Class II HDAC, HDAC4, and an HAT, PCAF, associate with cardiac myofilaments...
  79. doi HTLV-1 tax-induced NF-kappaB activation is synergistically enhanced by 12-O-tetradecanoylphorbol-13-acetate: mechanism and implications for Tax oncogenicity
    Inbal Azran-Shaish
    Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheba, 84105, Israel
    J Mol Med (Berl) 86:799-814. 2008
    ..the nucleus where p65 links to the cyclic adenosine monophosphate response element binding protein (CBP)-p300 and P/CAF coactivators that are essential for its transcriptional activity...
  80. ncbi Synergistic enhancement of nuclear receptor function by p160 coactivators and two coactivators with protein methyltransferase activities
    S S Koh
    Department of Pathology, University of Southern California, Los Angeles, California 90089, USA
    J Biol Chem 276:1089-98. 2001
    ..including histone acetyltransferases such as CREB-binding protein (CBP) and p300/CBP-associated factor (p/CAF), as well as the recently identified protein methyltransferase, coactivator-associated arginine methyltransferase 1 ..
  81. ncbi GCN5: a supervisor in all-inclusive control of vertebrate cell cycle progression through transcription regulation of various cell cycle-related genes
    Hidehiko Kikuchi
    Department of Life Science, Frontier Science Research Center, Miyazaki Medical College, University of Miyazaki, 5200, Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Gene 347:83-97. 2005
    ..To clarify participatory in vivo roles of two such enzymes known as GCN5 and PCAF, we generated homozygous DT40 mutants, DeltaGCN5 and DeltaPCAF, devoid of two alleles of each of the GCN5 and PCAF ..
  82. ncbi Hetero-association of caffeine and aromatic drugs and their competitive binding with a DNA oligomer
    D B Davies
    School of Biological and Chemical Sciences, Birkbeck College, University of London, UK
    Eur Biophys J 30:354-66. 2001
    NMR spectroscopy has been used to elucidate the molecular basis of the action of caffeine (CAF) on the complexation with DNA of mutagens such as ethidium bromide, propidium iodide, proflavine and acridine orange, and anticancer drugs ..
  83. pmc Spatial memory consolidation is associated with induction of several lysine-acetyltransferase (histone acetyltransferase) expression levels and H2B/H4 acetylation-dependent transcriptional events in the rat hippocampus
    Olivier Bousiges
    INSERM, U692, Laboratoire de Signalisations Moléculaires et Neurodégénérescence, Strasbourg, France
    Neuropsychopharmacology 35:2521-37. 2010
    ..E1A-binding protein p300 and p300/CBP-associated factor (PCAF) have also recently been involved in memory formation...
  84. ncbi Sintering mechanism of the CaF2 on hydroxyapatite by a 10.6-l microm CO2 laser
    Cheng Chei Wu
    Graduate Institute of Dental Science, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Lasers Surg Med 31:333-8. 2002
    ..For laser to be accepted in clinical applications, it is desired that, studies must show the incorporation of CaF(2) into hydroxyapatite could reduce the sintering temperature for the sake of safety.
  85. ncbi Modulation of the effects on learning and memory of nootropic drugs and central stimulants when applied together
    V D Petkov
    Institute of Physiology, Bulgarian Academy of Sciences, Sofia
    Acta Physiol Pharmacol Bulg 17:17-26. 1991
    ..of aniracetam p-P and p-F, standardized extract from ginseng roots (PG) and the psychostimulants caffeine (Caf) and amphetamine (Amph)...
  86. ncbi The DNA binding activities of Smad2 and Smad3 are regulated by coactivator-mediated acetylation
    Maria Simonsson
    Ludwig Institute for Cancer Research, Uppsala University, Biomedical Center, Box 595, Husargatan 3, S 751 24 Uppsala, Sweden
    J Biol Chem 281:39870-80. 2006
    ..translocated to the nucleus where they interact with coactivators and/or corepressors, including p300, CBP, and P/CAF, and regulate the expression of TGFbeta target genes...
  87. ncbi Ultraviolet radiation sensitivity and reduction of telomeric silencing in Saccharomyces cerevisiae cells lacking chromatin assembly factor-I
    P D Kaufman
    Cold Spring Harbor Laboratory, New York 11724, USA
    Genes Dev 11:345-57. 1997
    ..Previously, a protein complex from human cells, termed chromatin assembly factor-I (CAF-I), was isolated that assembles nucleosomes preferentially onto SV40 DNA templates that undergo replication in ..
  88. pmc Adenovirus E1B 55-kilodalton oncoprotein inhibits p53 acetylation by PCAF
    Y Liu
    Department of Microbiology and Infectious Diseases, Faculty of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
    Mol Cell Biol 20:5540-53. 2000
    ..It was shown recently that p53 is acetylated by transcriptional coactivators p300, CREB bidning protein (CBP), and PCAF and that acetylation of p53 by these proteins enhances p53 sequence-specific DNA binding...
  89. ncbi [Differential expression of collagen and matrix metalloproteinases between left and right atria in patients with chronic atrial fibrillation.]
    Guo Jun Xu
    Department of Cardiology, Xinjiang Medical University, Urumqi, China
    Sheng Li Xue Bao 61:211-6. 2009
    ..inhibitors of metalloproteinases (TIMPs) in the left and right atria in patients with chronic atrial fibrillation (CAF)...
  90. ncbi Acute exposure to caffeine decreases the anticonvulsant action of ethosuximide, but not that of clonazepam, phenobarbital and valproate against pentetrazole-induced seizures in mice
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Pharmacol Rep 58:652-9. 2006
    This study examines the effect of acute administration of caffeine sodium benzoate (CAF) on the anticonvulsant action of four conventional antiepileptic drugs (AEDs: clonazepam - CZP, ethosuximide - ETS, phenobarbital - PB and valproate -..
  91. ncbi Disruption of an RNA helicase/RNAse III gene in Arabidopsis causes unregulated cell division in floral meristems
    S E Jacobsen
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Development 126:5231-43. 1999
    ..A new recessive mutant, carpel factory (caf), converts the floral meristems to an indeterminate state...
  92. ncbi Patients with paroxysmal atrial fibrillation but not paroxysmal supraventricular tachycardia display evidence of platelet activation during arrhythmia
    Enver Atalar
    Department of Cardiology, Hacettepe University, Ankara, Turkey
    Platelets 14:407-11. 2003
    It is well known that chronic atrial fibrillation (CAF) and paroxysmal atrial fibrillation (PAF) are associated with hypercoagulable state...
  93. doi Minireview: role of kinases and chromatin remodeling in progesterone signaling to chromatin
    Guillermo P Vicent
    Centre de Regulacio Genomica, Universitat Pompeu Fabra, Parc de Recerca Biomedica, Aiguader 88, E 08003 Barcelona, Spain
    Mol Endocrinol 24:2088-98. 2010
    ..kinase 1, and the recruitment of a complex of the three activated proteins and of P300/CBP-associated factor (PCAF) to a single nucleosome, resulting in the phosphoacetylation of histone H3 and the displacement of heterochromatin ..
  94. pmc No calcium-fluoride-like deposits detected in plaque shortly after a sodium fluoride mouthrinse
    G L Vogel
    American Dental Association Foundation, Paffenbarger Research Center, Gaithersburg, MD 20899 8546, USA jvogel nist gov
    Caries Res 44:108-15. 2010
    Plaque 'calcium-fluoride-like' (CaF(2)-like) and fluoride deposits held by biological/bacterial calcium fluoride (Ca-F) bonds appear to be the source of cariostatic concentrations of fluoride in plaque fluid...
  95. pmc Control of trichome branching by chromatin assembly factor-1
    Vivien Exner
    Institute of Plant Sciences and Zurich Basel Plant Science Center, ETH Zurich, CH 8092 Zurich, Switzerland
    BMC Plant Biol 8:54. 2008
    ..Chromatin assembly factor CAF-1 is a histone chaperone that facilitates chromatin formation and the maintenance of specific chromatin states...
  96. ncbi The histone acetyltransferase domains of CREB-binding protein (CBP) and p300/CBP-associated factor are not necessary for cooperativity with the class II transactivator
    J A Harton
    Department of Microbiology and Immunology, The Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 276:38715-20. 2001
    ..histone acetyltransferase (HAT) activities of CREB-binding protein (CBP), p300, and/or p300/CBP-associated factor (pCAF)...
  97. ncbi The histone chaperone Asf1p mediates global chromatin disassembly in vivo
    Melissa W Adkins
    Department of Biochemistry and Molecular Genetics, University of Colorado Health Sciences Center at Fitzsimons, Aurora, Colorado 80045, USA
    J Biol Chem 279:52069-74. 2004
    ..the function of the histone H3/H4 chaperones anti-silencing function 1 (Asf1p) and chromatin assembly factor 1 (CAF-1) in vivo...
  98. ncbi A randomized clinical trial of continuous flow nitrous oxide and nalbuphine infusion for sedation of patients during radiofrequency atrial flutter ablation
    Gabriel Laurent
    Department of Cardiology, University Hospital Dijon, France
    Pacing Clin Electrophysiol 29:351-7. 2006
    In patients with common atrial flutter (CAF), radiofrequency ablation (RFA) causes discomfort. Patients undergoing RFA often feel pain which is difficult to control as the mechanisms are unclear.
  99. ncbi Combination chemotherapy for metastatic or recurrent carcinoma of the breast--a randomized phase III trial comparing CAF versus VATH versus VATH alternating with CMFVP: Cancer and Leukemia Group B Study 8281
    J Aisner
    University of Maryland Cancer Center, Baltimore, USA
    J Clin Oncol 13:1443-52. 1995
    ..We sought to compare three doxorubicin-based therapies for metastatic breast cancer for response frequency, time to treatment failure (TTF), and survival...
  100. pmc The Yersinia pestis caf1M1A1 fimbrial capsule operon promotes transmission by flea bite in a mouse model of bubonic plague
    Florent Sebbane
    Institut National de la Sante et de la Recherche Medicale, U801, Institut Pasteur de Lille, Lille, France
    Infect Immun 77:1222-9. 2009
    ..pestis strains are rarely isolated. We found that a caf-negative Y...
  101. doi Inhibition of IK,ACh current may contribute to clinical efficacy of class I and class III antiarrhythmic drugs in patients with atrial fibrillation
    Niels Voigt
    Department of Pharmacology and Toxicology, Dresden University of Technology, Fetscherstr 74, 01307, Dresden, Germany
    Naunyn Schmiedebergs Arch Pharmacol 381:251-9. 2010
    ..In chronic AF (cAF), I(K,ACh) develops a receptor-independent, constitutively active component that together with increased I(K1) is ..

Research Grants62

  1. WAYNE WILLIAM HANCOCK; Fiscal Year: 2015
    ..and/or pharmacologic approaches affect Treg function in vitro? Since preliminary data points to roles for the HATs, PCAF and p300, in control of Treg suppression, we will analyze the relative contribution of these HATs to regulation of ..
  2. Histone Acetylation and Insulin Gene Expression
    Sabire Ozcan; Fiscal Year: 2010
    ..important for Pdx-1 activity and/or DNA binding? 2) What role do the histone acetyltransferases p300/CBP and GCN5/PCAF play in glucose regulation of insulin gene expression? 3) Do the beta-cell specific transcription factors MafA and ..
  3. Ronen Marmorstein; Fiscal Year: 2016
    ..HATs fall into at least four families based on sequence conservation, Gcn5/PCAF, MYST, p300/CBP and Rtt109...
  4. Shelley L Berger; Fiscal Year: 2016
    ..The proposed studies will advance our understanding of how p53 protects cells, and our results will raise the likelihood for pharmacologic regulation of p53 function to fight human cancer. ..
  5. Role of IKK in NSCLC: Modulation of SMRT and NF-kappaB
    Marty W Mayo; Fiscal Year: 2012
    ..NF-?B stimulates gene expression of PRC proteins by recruiting IKK1 and PCAF to responsive promoters and derepressing SMRT (silencing mediator for retinoid and thyroid hormone receptors) and ..
  6. ABUSE LIABILITY OF DRUG ADJUNCTS FOR COCAINE WITHDRAWL
    Frank Holloway; Fiscal Year: 1992
    ..The present proposal would extend the analysis of these legal stimulant combinations (e.g., caffeine (CAF), ephedrine (EPH), and phenylpropanolamine (PPA))...
  7. Nicola C Partridge; Fiscal Year: 2016
    ..In the nucleus, Runx2 then recruits the histone acetyl transferases (HATs), p300 and p300/CBP associated factor (PCAF)...
  8. Regulation of CFTR gene expression
    Martin Walsh; Fiscal Year: 2004
    ..acetyltransferase coactivator proteins, p300/CREB-binding protein (p300/CBP) and p300/CBP-associated factor (PCAF) mediate histone acetylation of CFTR...
  9. Maria Trojanowska; Fiscal Year: 2016
    ..We uncovered a novel mechanism whereby TGF-2 abrogates inhibitory effects of Fli-1 through PCAF-mediated acetylation...
  10. Effect of chromatin remodelers/modifiers on HIV-1 Tat activated transcription
    Fatah Kashanchi; Fiscal Year: 2010
    ..T1 to initiate HIV-1 transcription while acetylated Tat complexes with SWI/SNF and p300/CBP- associated factor (p/CAF) to promote transcriptional elongation...
  11. Zhiguo Zhang; Fiscal Year: 2015
    ..Histone chaperones CAF-1, Asf1 and Rtt106 function together to promote nucleosome assembly during S phase of the cell cycle...
  12. Zhiguo Zhang; Fiscal Year: 2015
    ..H3.1-H4 is assembled into nucleosomes by the histone chaperone CAF-1 in a replication-coupled nucleosome assembly process, and H3...
  13. ROLE OF CHROMATIN IN HIV TRANSCRIPTIONAL REGULATION
    ERIC M VERDIN; Fiscal Year: 2010
    ..We have demonstrated that the chromatin regulators p300, huSWI/SNF, and PCAF participate to the transcriptional regulation of HIV transcription in the context of chromatin...
  14. Development of an HTS assay for ySas2/hMOF histone acetyltransferase inhibitors
    Ronen Marmorstein; Fiscal Year: 2013
    ..There are at least four families including Gcn5/PCAF, p300/CBP, MYST and Rtt109...
  15. Molecular Mechanism of Histone H3/H4 Chaperone Function
    MAIR E CHURCHILL; Fiscal Year: 2010
    ..assembly are the histone H3 and H4 chaperones Anti-silencing function 1 (Asf1) and the Chromatin Assembly Factor (CAF-1) complex...
  16. Histone Modification Mechanisms and Inhibition
    Philip A Cole; Fiscal Year: 2012
    ..Virtual ligand screening will be employed based on the crystal structures of p300/CBP HAT and PCAF/GCN5 HAT in complex with bisubstrate analogs...
  17. Structure/Function of Human Papillomavirus Oncoproteins
    Ronen Marmorstein; Fiscal Year: 2006
    ..Adenovirus E1A (Ad-ElA), also inhibits the activity of pRb as well as other transcriptional cofactors such as the P/CAF and CBP/p300 histone acetyltransferases...
  18. Paul D Kaufman; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Chromatin Assembly Factor-1 (CAF-1) is a three-subunit protein complex conserved throughout eukaryotes...
  19. Acetylation of Androgen Receptor in Prostate Growth
    Maofu Fu; Fiscal Year: 2004
    ..We found that the AR is a direct target of the histone acetyltransferase p300 and p/CAF, and the acetylation of the AR is essential to its ligand-dependent activation...
  20. Oncolytic Viruses with Therapeutic Genes in the Treatment of Breast Cancer
    DANUTA B KOZBOR; Fiscal Year: 2013
    ..We propose to identify the key events of the CAF/MDSC interaction that regulates expression of IRF8 by analyzing changes in the production of tumor- derived factors ..
  21. Deregulation of Cell Pathways by Ad E1B 55K Oncoproteins
    Daiqing Liao; Fiscal Year: 2005
    ..that Ad E1B 55-kDa proteins repress p53 transactivation by specifically inhibiting acetylation of p53 by acetylase PCAF. As p53 acetylation at specific lysine residues by PCAF and p300 is crucial for its transactivation function and ..
  22. Functional Consequences of C/EBPB Acetylation
    Teresa Cesena; Fiscal Year: 2007
    ..C/EBPp was found to be acetylated by p300 and P/CAF. Four lysines in C/EBPp have so far been identified as potential sites for acetylation, and when each was mutated ..
  23. Matrix remodeling in tumor growth and metastasis in a murine breast cancer model
    Lisa L Chang; Fiscal Year: 2011
    ..Importantly, unpublished work from our lab (J.Tchou and E. Puri) shows that FAP can be used as a robust pan-CAF marker in human breast cancer, it being superior to other CAF markers in its selectivity and specificity...
  24. Role of Innate Immunity in Controlling HIV Infection
    Jay A Levy; Fiscal Year: 2010
    ..It is associated with secretion of an unidentified CD8+ cell antiviral factor (CAF), a protein stable to heat and low pH that inhibits HIV transcription...
  25. Role of Fibroblasts in Cancer
    Raghu Kalluri; Fiscal Year: 2010
    ..regarding the role of the resting and the activated fibroblasts (also known as carcinoma-associated fibroblasts, CAF) in cancer is still evolving...
  26. Amanda C LaRue; Fiscal Year: 2015
    ..The major component of solid tumor stroma is the carcinoma associated fibroblast (CAF), which generates structural matrix, stimulates growth, supports neovascularization and promotes metastasis of ..
  27. Andreas Friedl; Fiscal Year: 2014
    ..Carcinoma-associated fibroblasts (CAF) distinguish themselves from normal mammary fibroblasts (NMF) by morphology, gene expression and secreted factors...
  28. Dental outcomes in Fibrous Dysplasia/McCune Albright Syndrome
    Sunday O Akintoye; Fiscal Year: 2013
    ..by GNAS1 gene mutation is characterized by polyostotic fibrous dysplasia of bone (FD), endocrine disorders and caf[unreadable]-au-lait skin hyperpigmentation. FD affects craniofacial bones including the jaws in 90% of cases...
  29. Bombesin-Activated Carcinoma Associated Fibroblasts in Colorectal Cancer
    Celia Chao; Fiscal Year: 2013
    ..We will examine BN-mediated CAF proliferation, activation of the MEK/ERK pathway, regulation of COX-2 promoter activity and upregulation of ..
  30. KLF2 as a novel regular for monocyte activation and function
    Hiranmoy Das; Fiscal Year: 2012
    ..and activator protein-1 in part by means of recruitment of transcriptional coactivator p300/CBP-associated factor, PCAF. These observations implicate KLF2 as a novel negative regulator of monocytic activation...
  31. CELL CYCLE CONTROL AFTER IRRADIATION
    Ruth Muschel; Fiscal Year: 2003
    ..These boxes bind the transcription factor NF-Y and through NF-Y the related histone acetyltransferases GCN5 and P/CAF suggesting that histone acetyl transferase (HAT) activity might play a role in the cell cycle regulation of cyclin ..
  32. ACETYLTRANSFERASES AND ONCOGENESIS
    Maria Avantaggiati; Fiscal Year: 2003
    ..I have now demonstrated that post-translational acetylation of p53 by the acetyl-transferase, P/CAF, restores sequence specific DNA-binding of p53 mutant proteins otherwise dysfunctional for binding to DNA...
  33. Ion chromatograph-high resolution ICPMS for speciation
    Brian T Buckley; Fiscal Year: 2012
    ..The Chemical Analysis Facility Core (CAF) is requesting support to purchase a Nu Instruments ICP/two sector high resolution (HR) mass spectrometer coupled ..
  34. Prevention of Complications of Thalassemia
    Patricia J Giardina; Fiscal Year: 2011
    ..consumer organizations are maintained with the Thalassemia Action Group (TAG), the Cooley's Anemia Foundation (CAF) and local healthcare providers at smaller non-federally funded regional institutions which care for fewer ..
  35. Strategies for gene and protein delivery for cancer therapy
    Harald Sauthoff; Fiscal Year: 2012
    ..Carcinoma-associated-fibroblasts (CAF) communicate with cancer cells through the secretion of cytokines, such as SDF-1, VEGF or IL-6, and support tumor ..
  36. PATHOGENESIS AND PROGRESSION OF PROSTATE CANCER
    Pradip Roy-Burman; Fiscal Year: 2012
    ..Our first aim is to elucidate the mechanisms by which BMP induces CAF cells to produce and secrete SDF-1, using cell systems from both mouse and human prostate cancer, and to define the ..
  37. Simon Andrew Gayther; Fiscal Year: 2014
    ..profile changes in the expression of a class of regulatory RNAs, long non-coding RNAs (lncRNAs), which occur during CAF development...
  38. A Novel Approach to Identify HIV Suppression Factor from CD8 Cells
    Phalguni Gupta; Fiscal Year: 2010
    ..Yet the identity of the T cell mediated antiviral factor (CAF) remained elusive for last 20 years...
  39. TIMOTHY CRAGIN WANG; Fiscal Year: 2015
    ..The focus of the program is the role of myofibroblasts (MF)/cancer-associated fibroblasts (CAF) in digestive cancers, and includes studies of gastric, hepatocellular and pancreatic cancer...
  40. Mabel Ryder; Fiscal Year: 2014
    ..We will examine the effects of TAMs on the recruitment, differentiation and/or proliferation of CAF progenitors from the bone-marrow and thyroid...
  41. JoAnne L Flynn; Fiscal Year: 2016
    ..propose to optimize a promising new adjuvant developed by Statens Serum Institute (SSI), CAF09, which builds on the CAF platform of cationic nanoparticles composed of bioactive lipids...
  42. Keith Syson Chan; Fiscal Year: 2016
    ..This application has its foundation via demonstrating that bladder cancer patients with an elevated expression of CAF genes also have muscle-invasive cancer and a poorer survival...
  43. Regulation of NF-kappaB transactivation function
    BRIAN ASHBURNER; Fiscal Year: 2009
    ..These coactivators include the CREB-binding protein (CBP) and its homolog, p300;the p300/CBP associated factor (P/CAF);and members of the steroid receptor coactivator (p160/SRC) family...
  44. Drug Interactions and Bioavailability of Cranberry
    Jennifer Donovan; Fiscal Year: 2005
    ..of the three safe, probe drugs alprazolam (ALPZ; 3A4 probe), dextromethorphan (DM; CYP2D6 probe), and caffeine (CAF; CYP1A2 probe) will be administered at baseline (before treatment with CB) and after a 14-day treatment period with ..
  45. Alphonse E Sirica; Fiscal Year: 2016
    ..validate an innovative moleculr strategy for ICC therapy based on combinational targeting of interactive ?-SMA+CAF/ cholangiocarcinoma cell pathways (e.g...
  46. Regulation of the miRNA-directed Reprogramming of Normal Omental Fibroblasts
    FREDERICK KOHLHAPP; Fiscal Year: 2013
    ..CAFs shared a large number of upregulated genes highly enriched in chemokines, which are known to be important for CAF function 3. The most highly upregulated chemokine, CCL5, was found to be a direct target of miR- 214 3...
  47. Kazuki Sugahara; Fiscal Year: 2016
    ..In addition to utilizing CAFs as a mediator of tissue penetration, iRGD also appears to affect CAF functions and alter tumor microenvironment...
  48. Weizhou Zhang; Fiscal Year: 2014
    ..of the proposed research is to understand how cancer associated stroma, including cancer associated fibroblast (CAF), tumor infiltrating lymphocytes (TIL) and their interactions with carcinoma cells contributes to pulmonary ..
  49. Pharmacogenetics: Breast Cancer Treatment and Prognosis
    Christine Ambrosone; Fiscal Year: 2005
    The proposed study uses data and specimens from a Southwest Oncology Group (SWOG) breast cancer clinical trial of CAF or CMF to investigate inherited factors that may impact prognosis...
  50. Lee E Limbird; Fiscal Year: 2016
    ..and skill-building sessions, ii) a Career Roundtable, and iii) the monthly university-wide COOL SCIENCE CAF[unreadable];and also b) engaging in a 6 wk...
  51. Flow Cytometer to Extend Laboratory Capabilities
    CHARLES ARTHUR KUSZYNSKI; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The Cell Analysis Facility (CAF), a core facility of the University of Nebraska Medical Center (UNMC), is requesting $581,998...
  52. Communicore Animal Facility (CAF) Renovation Phase III Part II
    AUGUST BATTLES; Fiscal Year: 2007
    ..describes a three-phase plan to modernize the largest existing animal facility, the Communicore Animal Facility (CAF), and further centralize the animal resource program...
  53. HIV1 INHIBITORY PROTEINS FROM TRANSFORMED CD8+ CELLS
    Mary Klotman; Fiscal Year: 2002
    ..cell to cell contact and is mediated through soluble factors, hence the original name CD8+- cell antiviral factors (CAF)...
  54. UPGRADE AND RENOVATION OF UK ANIMAL RESEARCH FACILITY
    LESLIE SHERWOOD; Fiscal Year: 2004
    ..of Kentucky (UK) requests $700,000 support for alterations and renovations to the Central Animal Facility (CAF)...
  55. TRANSCRIPTIONAL REGULATION OF HTLV GENE EXPRESSION
    SUSAN MARRIOTT; Fiscal Year: 2006
    ..g. cbp/p300, p/caf)...
  56. SUPPRESSION OF HIV REPLICATION BY CD8+ CELLS
    Jay Levy; Fiscal Year: 1999
    ..that this non-MHC restricted antiviral response is mediated at least in part by a novel antiviral factor (CAF) produced by CD8+ cells...
  57. CRANIOFACIAL DEVELOPMENTAL MOLECULAR BIOLOGY
    Charles Shuler; Fiscal Year: 2003
    ..Kedes) "Co-Activators and Repressors of Muscle Transcription," will investigate the activity of Twist, p300/CBP and PCAF during the differentiation of muscle cells. Project 3 (Dr...
  58. Phenotyping & genotype-phenotype correlations in NF1
    Bruce Korf; Fiscal Year: 2006
    ..We will gather detailed data concerning numbers of dermal neurofibromas, number of caf&eacute;-au-lait spots, and number and location of internal plexiform neurofibromas and spinal neurofibromas, in ..
  59. METABOLIC REGULATION OF LIPOPROTEIN LIPASE IN ADIPOCYTES
    Richard Currie; Fiscal Year: 2002
    ..unidentified protein which modulate transactivation potential; and 5) The histone acetyltransferases GCN5 and P/CAF remodel the chromatin around the LPL promoter CCAAT-box through their interaction with NF-Y...
  60. REGULATION OF INTESTINE-SPECIFIC GENE TRANSCRIPTION
    Eunran Suh; Fiscal Year: 2006
    ..by forming a complex with hepatocyte nuclear factor 1 (HNF1), GATA factors, and coactivators such as CBP and PCAF. This current grant proposal is based on the hypothesis that Cdx1 and Cdx2 functions are modulated by post-..
  61. RR-03-011, Extramural Research Facilities Improvement P*
    WINFRED PHILLIPS; Fiscal Year: 2004
    ..7M, 62,975-gsf animal acility annex to the J. Hillis Miller Health Center Communicore Animal Facility (CAF), the largest animal facility on campus. The CAF is currently used by over 117 Investigators...
  62. SUPPRESSION OF HIV REPLICATION BY CD8+ CELLS
    Jay Levy; Fiscal Year: 2000
    ..that this non-MHC restricted antiviral response is mediated, at least in part, by a novel CD8+ antiviral factor (CAF). CAF is made at highest levels by CD8+ cells from asymptomatic individuals and long term survivors...